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1.
  • Adriani, O., et al. (författare)
  • Cosmic-Ray Electron Flux Measured by the PAMELA Experiment between 1 and 625 GeV
  • 2011
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 106:20, s. 201101-
  • Tidskriftsartikel (refereegranskat)abstract
    • Precision measurements of the electron component in the cosmic radiation provide important information about the origin and propagation of cosmic rays in the Galaxy. Here we present new results regarding negatively charged electrons between 1 and 625 GeV performed by the satellite-borne experiment PAMELA. This is the first time that cosmic-ray e(-) have been identified above 50 GeV. The electron spectrum can be described with a single power-law energy dependence with spectral index -3.18 +/- 0.05 above the energy region influenced by the solar wind (> 30 GeV). No significant spectral features are observed and the data can be interpreted in terms of conventional diffusive propagation models. However, the data are also consistent with models including new cosmic-ray sources that could explain the rise in the positron fraction.
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2.
  • Adriani, O., et al. (författare)
  • Cosmic-Ray Positron Energy Spectrum Measured by PAMELA
  • 2013
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 111:8, s. 081102-
  • Tidskriftsartikel (refereegranskat)abstract
    • Precision measurements of the positron component in the cosmic radiation provide important information about the propagation of cosmic rays and the nature of particle sources in our Galaxy. The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray positron flux and fraction that extends previously published measurements up to 300 GeV in kinetic energy. The combined measurements of the cosmic-ray positron energy spectrum and fraction provide a unique tool to constrain interpretation models. During the recent solar minimum activity period from July 2006 to December 2009, approximately 24 500 positrons were observed. The results cannot be easily reconciled with purely secondary production, and additional sources of either astrophysical or exotic origin may be required.
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3.
  • Adriani, O., et al. (författare)
  • Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
  • 2013
  • Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
  • Tidskriftsartikel (refereegranskat)abstract
    • It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
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4.
  • Adriani, O., et al. (författare)
  • Measurement of the isotopic composition of hydrogen and helium nuclei in cosmic rays with the PAMELA experiment
  • 2013
  • Ingår i: Astrophysical Journal. - : IOP Publishing. - 0004-637X .- 1538-4357. ; 770:1, s. 2-
  • Tidskriftsartikel (refereegranskat)abstract
    • The satellite-borne experiment PAMELA has been used to make new measurements of cosmic ray H and He isotopes. The isotopic composition was measured between 100 and 600 MeV /n for hydrogen and between 100 and 900 MeV /n for helium isotopes over the 23rd solar minimum from 2006 July to 2007 December. The energy spectrum of these components carries fundamental information regarding the propagation of cosmic rays in the galaxy which are competitive with those obtained from other secondary to primary measurements such as B/C.
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5.
  • Adriani, O., et al. (författare)
  • Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
  • 2013
  • Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
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6.
  • Adriani, O., et al. (författare)
  • Measurements of quasi-trapped electron and positron fluxes with PAMELA
  • 2009
  • Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114, s. A12218-
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents precise measurements of the differential energy spectra of quasi-trapped secondary electrons and positrons and their ratio between 80 MeV and 10 GeV in the near-equatorial region (altitudes between 350 km and 600 km). Latitudinal dependences of the spectra are analyzed in detail. The results were obtained from July until November 2006 onboard the Resurs-DK satellite by the PAMELA spectrometer, a general purpose cosmic ray detector system built around a permanent magnet spectrometer and a silicon-tungsten calorimeter.
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7.
  • Adriani, O., et al. (författare)
  • OBSERVATIONS OF THE 2006 DECEMBER 13 AND 14 SOLAR PARTICLE EVENTS IN THE 80 MeV n(-1)-3 GeV n(-1) RANGE FROM SPACE WITH THE PAMELA DETECTOR
  • 2011
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 742:2, s. 102-
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the space spectrometer PAMELA observations of proton and helium fluxes during the 2006 December 13 and 14 solar particle events. This is the first direct measurement of the solar energetic particles in space with a single instrument in the energy range from similar to 80 MeV n(-1) up to similar to 3 GeV n(-1). For the December 13 event, measured energy spectra of solar protons and helium are compared with results obtained by neutron monitors and other detectors. Our measurements show a spectral behavior different from those derived from the neutron monitor network. No satisfactory analytical fitting was found for the energy spectra. During the first hours of the December 13 event, solar energetic particles spectra were close to the exponential form, demonstrating rather significant temporal evolution. Solar He with energy up to 1 GeV n(-1) was recorded on December 13. For the December 14 event, energy of solar protons reached 600 MeV, whereas the maximum energy of He was below 100 MeV n(-1). The spectra were slightly bent in the lower energy range and preserved their form during the second event. Differences in the particle flux appearance and temporal evolution of these two events may argue for special conditions leading to the acceleration of solar particles up to relativistic energies.
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8.
  • Adriani, O., et al. (författare)
  • PAMELA Measurements of Cosmic-Ray Proton and Helium Spectra
  • 2011
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 332:6025, s. 69-72
  • Tidskriftsartikel (refereegranskat)abstract
    • Protons and helium nuclei are the most abundant components of the cosmic radiation. Precise measurements of their fluxes are needed to understand the acceleration and subsequent propagation of cosmic rays in our Galaxy. We report precision measurements of the proton and helium spectra in the rigidity range 1 gigavolt to 1.2 teravolts performed by the satellite-borne experiment PAMELA (payload for antimatter matter exploration and light-nuclei astrophysics). We find that the spectral shapes of these two species are different and cannot be described well by a single power law. These data challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. More complex processes of acceleration and propagation of cosmic rays are required to explain the spectral structures observed in our data.
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9.
  • Adriani, O., et al. (författare)
  • PAMELA Results on the Cosmic-Ray Antiproton Flux from 60 MeV to 180 GeV in Kinetic Energy
  • 2010
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:12, s. 121101-
  • Tidskriftsartikel (refereegranskat)abstract
    • The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray antiproton flux and the antiproton-to-proton flux ratio which extends previously published measurements down to 60 MeV and up to 180 GeV in kinetic energy. During 850 days of data acquisition approximately 1500 antiprotons were observed. The measurements are consistent with purely secondary production of antiprotons in the Galaxy. More precise secondary production models are required for a complete interpretation of the results.
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10.
  • Adriani, O., et al. (författare)
  • The PAMELA Mission : Heralding a new era in precision cosmic ray physics
  • 2014
  • Ingår i: Physics reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 544:4, s. 323-370
  • Forskningsöversikt (refereegranskat)abstract
    • On the 15th of June 2006, the PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) satellite-borne experiment was launched onboard the Russian Resurs-DK1 satellite by a Soyuz rocket from the Baikonur space centre. The satellite was placed in a quasi-polar 70 degrees inclination orbit at an altitude varying between 350 km and 600 km. New results on the antiparticle component of the cosmic radiation were obtained. The positron energy spectrum and positron fraction were measured from 400 MeV up to 200 GeV revealing a positron excess over the predictions of commonly used propagation models. This can be interpreted either as evidence that the propagation models should be revised or in terms of dark matter annihilation or a pulsar contribution. The antiproton spectrum was measured over the energy range from 60 MeV to 350 GeV. The antiproton spectrum is consistent with secondary production and significantly constrains dark matter models. The energy spectra of protons and helium nuclei were measured up to 1.2 TV. The spectral shapes of these two species are different and cannot be described well by a single power law. For the First time the electron spectrum was measured up to 600 GeV complementing the information obtained from the positron data. Nuclear and isotopic composition was obtained with unprecedented precision. The variation of the low energy proton, electron and positron energy spectra was measured from July 2006 until December 2009 accurately sampling the unusual conditions of the most recent solar minimum activity period (2006-2009). Low energy particle spectra were accurately measured also for various solar events that occurred during the PAMELA mission. The Earth's magnetosphere was studied measuring the particle radiation in different regions of the magnetosphere. Energy spectra and composition of sub-cutoff and trapped particles were obtained. For the first time a belt of trapped antiprotons was detected in the South Atlantic Anomaly region. The flux was found to exceed that for galactic cosmic-ray antiprotons by three order of magnitude.
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11.
  • Adriani, O., et al. (författare)
  • Time Dependence Of The Proton Flux Measured By Pamela During The 2006 July-2009 December Solar Minimum
  • 2013
  • Ingår i: Astrophysical Journal. - : IOP Publishing. - 0004-637X .- 1538-4357. ; 765:2, s. 91-
  • Tidskriftsartikel (refereegranskat)abstract
    • The energy spectra of galactic cosmic rays carry fundamental information regarding their origin and propagation. These spectra, when measured near Earth, are significantly affected by the solar magnetic field. A comprehensive description of the cosmic radiation must therefore include the transport and modulation of cosmic rays inside the heliosphere. During the end of the last decade, the Sun underwent a peculiarly long quiet phase well suited to study modulation processes. In this paper we present proton spectra measured from 2006 July to 2009 December by PAMELA. The large collected statistics of protons allowed the time variation to be followed on a nearly monthly basis down to 400 MV. Data are compared with a state-of-the-art three-dimensional model of solar modulation.
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12.
  • Austin, Thomas R., et al. (författare)
  • A plasma protein-based risk score to predict hip fractures
  • 2024
  • Ingår i: NATURE AGING. - 2662-8465.
  • Tidskriftsartikel (refereegranskat)abstract
    • As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Tr & oslash;ndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined. The authors developed a proteomic risk score that improved the prediction of hip fractures in three validation cohorts analyzed by two different proteomic platforms. This risk score constitutes a new tool to stratify patients by hip fracture risk.
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13.
  • Austin, Thomas R, et al. (författare)
  • Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures.
  • 2024
  • Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 1523-4681. ; 39:2, s. 139-149
  • Tidskriftsartikel (refereegranskat)abstract
    • Hip fractures are associated with significant disability, high cost, and mortality. However, the exact biological mechanisms underlying susceptibility to hip fractures remain incompletely understood. In an exploratory search of the underlying biology as reflected through the circulating proteome, we performed a comprehensive Circulating Proteome Association Study (CPAS) meta-analysis for incident hip fractures. Analyses included 6430 subjects from two prospective cohort studies (Cardiovascular Health Study and Trøndelag Health Study) with circulating proteomics data (aptamer-based 5K SomaScan version 4.0 assay; 4979 aptamers). Associations between circulating protein levels and incident hip fractures were estimated for each cohort using age and sex-adjusted Cox regression models. Participants experienced 643 incident hip fractures. Compared with the individual studies, inverse-variance weighted meta-analyses yielded more statistically significant associations, identifying 23 aptamers associated with incident hip fractures (conservative Bonferroni correction 0.05/4979, P<1.0×10-5). The aptamers most strongly associated with hip fracture risk corresponded to two proteins of the growth hormone/insulin growth factor system (GHR and IGFBP2), as well as GDF15 and EGFR. High levels of several inflammation-related proteins (CD14, CXCL12, MMP12, ITIH3) were also associated with increased hip fracture risk. Ingenuity pathway analysis identified reduced LXR/RXR activation and increased acute phase response signaling to be overrepresented among those proteins associated with increased hip fracture risk. These analyses identified several circulating proteins and pathways consistently associated with incident hip fractures. These findings underscore the usefulness of the meta-analytic approach for comprehensive CPAS in a similar manner as has previously been observed for large-scale human genetic studies. Future studies should investigate the underlying biology of these potential novel drug targets.
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14.
  • Bazilevskaya, G. A., et al. (författare)
  • Solar energetic particle events in 2006-2012 in the PAMELA experiment data
  • 2013
  • Ingår i: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 409:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA magnetic spectrometer launched in June 2006 has observed the last strong energetic solar particle event of the 23rd solar cycle in December 2006. Subsequent long minimum of solar activity and weak development of the 24th solar cycle led to a deficit in the solar energetic particle events on the Earth orbit. As a result, only few events with protons accelerated above 100 MeV occurred in 2010-2012. The paper gives the preliminary results on energetic solar particles in the beginning of the 24th solar circle as measured with the PAMELA instrument.
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15.
  • Bazilevskaya, G. A., et al. (författare)
  • Solar proton events at the end of the 23rd and start of the 24th solar cycle recorded in the PAMELA experiment
  • 2013
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 493-496
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA magnetic spectrometer was launched into a near-Earth orbit on board the Resurs-DK1 satellite in June 2006; in December 2006, it recorded the last strong solar high-energy particle event of the 23rd solar cycle. A deficit was thereafter observed in solar energetic particle events because of the lengthy solar activity minimum and the weak evolution of the next (24th) solar cycle. As a result, only a few solar events involving protons with energies of more than 100 MeV were recorded between 2010 and 1012. This work presents the preliminary results from measurements of charged particle fluxes in these events, recorded by the Pamela spectrometer.
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16.
  • Bruno, A., et al. (författare)
  • First detection of geomagnetically trapped antiprotons by the PAMELA experiment
  • 2011
  • Ingår i: Proceedings of the 32nd International Cosmic Ray Conference, ICRC 2011. - : Institute of High Energy Physics. ; , s. 86-89
  • Konferensbidrag (refereegranskat)abstract
    • We present the measurement of geomagnetically trapped antiprotons in the South Atlantic Anomaly performed by the PAMELA satellite-bourne experiment. The existence of an antiproton radiation belt, predicted by several models as the product of cosmic ray interactions with the residual terrestrial atmosphere, is evidenced for the first time. PAMELA measured the antiproton spectrum in the kinetic energy range between 60 and 750 MeV, reporting a trapped antiproton flux which exceeds by about 3 orders of magnitude the interplanetary cosmic ray antiproton flux. An estimation of the mean under-cutoff antiproton flux outside radiation belts has been also provided.
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17.
  • Bruno, A., et al. (författare)
  • Precise cosmic rays measurements with PAMELA
  • 2013
  • Ingår i: Acta Polytechnica. - 1210-2709. ; 53:Suppl.1, s. 712-717
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA experiment was launched on board the Resurs-DK1 satellite on June 15th 2006. The apparatus was designed to conduct precision studies of charged cosmic radiation over a wide energy range, from tens of MeV up to several hundred GeV, with unprecedented statistics. In five years of continuous data taking in space, PAMELA accurately measured the energy spectra of cosmic ray antiprotons and positrons, as well as protons, electrons and light nuclei, sometimes providing data in unexplored energetic regions. These important results have shed new light in several astrophysical fields like: an indirect search for Dark Matter, a search for cosmological antimatter (anti-Helium), and the validation of acceleration, transport and secondary production models of cosmic rays in the Galaxy. Some of the most important items of Solar and Magnetospheric physics were also investigated. Here we present the most recent results obtained by the PAMELA experiment.
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18.
  • Bruno, A., et al. (författare)
  • Trapped protons in SAA measured by the PAMELA experiment
  • 2011
  • Ingår i: Proceedings of the 32nd International Cosmic Ray Conference, ICRC 2011. - : Institute of High Energy Physics. ; , s. 82-85
  • Konferensbidrag (refereegranskat)abstract
    • An accurate measurement of under cutoff proton fluxes in the energy range 60 MeV ÷ 3 GeV has been performed by the PAMELA satellite-borne experiment. Thanks to the high identification performances and to the semipolar and elliptic satellite orbit, PAMELA is able to provide information about spectra and composition of particles in different regions of the magnetosphere. Here we present the measurement of the geomagnetically trapped protons from the inner radiation belt (SAA). The fluxes as a function of equatorial pitch angle and McIlwain L-shell are reported.
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19.
  • Carbone, Marco, et al. (författare)
  • European Society for Organ Transplantation (ESOT) Consensus Statement on Outcome Measures in Liver Transplantation According to Value-Based Health Care
  • 2023
  • Ingår i: Transplant International. - 0934-0874. ; 36, s. 12190-
  • Tidskriftsartikel (refereegranskat)abstract
    • Liver transplantation is a highly complex, life-saving, treatment for many patients with advanced liver disease. Liver transplantation requires multidisciplinary teams, system-wide adaptations and significant investment, as well as being an expensive treatment. Several metrics have been proposed to monitor processes and outcomes, however these lack patient focus and do not capture all aspects of the process. Most of the reported outcomes do not capture those outcomes that matter to the patients. Adopting the principles of Value-Based Health Care (VBHC), may provide an opportunity to develop those metrics that matter to patients. In this article, we present a Consensus Statement on Outcome Measures in Liver Transplantation following the principles of VBHC, developed by a dedicated panel of experts under the auspices of the European Society of Organ Transplantation (ESOT) Guidelines’ Taskforce. The overarching goal is to provide a framework to facilitate the development of outcome measures as an initial step to apply the VMC paradigm to liver transplantation.
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20.
  • De Simone, N., et al. (författare)
  • PAMELA : Measurements of matter and antimatter in space
  • 2011
  • Ingår i: Nuovo cimento della societa italiana de fisica. C, Geophysics and space physics. - 1124-1896 .- 1826-9885. ; 34:3, s. 79-87
  • Tidskriftsartikel (refereegranskat)abstract
    • On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail counter scintillator and a neutron detector. The combination of these devices allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV-100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectra in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (antihelium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA investigates phenomena connected with solar and earth physics. The main results and updated data will be presented.
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21.
  • Giaccari, U., et al. (författare)
  • Anisotropy studies in the cosmic ray proton flux with the PAMELA experiment
  • 2013
  • Ingår i: Proceedings of the 9th workshop on Science with the New Generation of High Energy Gamma-ray Experiments: From high energy gamma sources to cosmic rays, one century after their discovery. - : Elsevier. ; , s. 123-128
  • Konferensbidrag (refereegranskat)abstract
    • Using data taken by the Pamela experiment during 5 years of operation we studied the anisotropy in the arrival direction distribution of cosmic ray protons with rigidity above 40 GV. In this survey we used two different and independent techniques to investigate the large and medium anisotropy patterns in the proton spectrum. With both methods the observed distribution of arrival directions is consistent with the isotropic expectation and no significant evidence of strong anisotropies has been observed.
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22.
  • Gruber, Günther, et al. (författare)
  • Prognostic value of extracapsular tumor spread for locoregional control in premenopausal patients with node-positive breast cancer treated with classical cyclophosphamide, methotrexate, and fluorouracil: long-term observations from International Breast Cancer Study Group Trial VI.
  • 2005
  • Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 0732-183X. ; 23:28, s. 7089-97
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: We sought to determine retrospectively whether extracapsular spread (ECS) might identify a subgroup that could benefit from radiotherapy after mastectomy, especially patients with 1 to 3 positive lymph nodes (LN1-3+). PATIENTS AND METHODS: We randomized 1,475 premenopausal women with node-positive breast cancer to three, six, or nine courses of "classical" CMF (cyclophosphamide, methotrexate, and fluorouracil). After a review of all pathology forms, 933 patients (63%) had information on the presence or absence of ECS. ECS was present in 49.5%. The median follow-up was 10 years. RESULTS: In univariate analyses, ECS was associated with worse disease-free survival (DFS) and overall survival (OS). In multivariate analyses adjusting for tumor size, vessel invasion, surgery type, and age group, ECS remained significant (DFS: hazard ratio, 1.61; 95% CI, 1.34 to 1.93; P < .0001; OS: 1.67; 95% CI, 1.34 to 2.08; P < .0001). However, ECS was not significant when the number of positive nodes was added. The locoregional failure rate +/- distant failure (LRF +/- distant failure) within 10 years was estimated at 19% (+/- 2%) without ECS, versus 27% (+/- 2%) with ECS. The difference was statistically significant in univariate analyses, but not after adjusting for the number of positive nodes. No independent effect of ECS on DFS, OS, or LRF could be confirmed within the subgroup of 382 patients with LN1-3+ treated with mastectomy without radiotherapy. CONCLUSION: Our results do not support an independent prognostic value of ECS, nor its use as an indication for irradiation in premenopausal patients with LN1-3+ treated with classical CMF. However, we could not examine whether extensive ECS is of prognostic importance.
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23.
  • Humphries, Matthew P., et al. (författare)
  • A case-matched gender comparison transcriptomic screen identifies eIF4E and eIF5 as potential prognostic markers in male breast cancer
  • 2017
  • Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 23:10, s. 2575-2583
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assumptions that underlying biology is similar. Experimental Design: A transcriptomic investigation of male and female breast cancer was performed, confirming transcriptomic data in silico. Biomarkers were immunohistochemically assessed in 697 MBCs (n = 477, training; n = 220, validation set) and quantified in pre- and posttreatment samples from an MBC patient receiving everolimus and PI3K/mTOR inhibitor. Results: Gender-specific gene expression patterns were identified. eIF transcripts were upregulated in MBC. eIF4E and eIF5 were negatively prognostic for overall survival alone (log-rank P = 0.013; HR = 1.77, 1.12-2.8 and P = 0.035; HR = 1.68, 1.03-2.74, respectively), or when coexpressed (P = 0.01; HR = 2.66, 1.26-5.63), confirmed in the validation set. This remained upon multivariate Cox regression analysis [eIF4E P = 0.016; HR = 2.38 (1.18-4.8), eIF5 P = 0.022; HR = 2.55 (1.14-5.7); coexpression P = 0.001; HR = 7.04 (2.22-22.26)]. Marked reduction in eIF4E and eIF5 expression was seen post BEZ235/everolimus, with extended survival. Conclusions: Translational initiation pathway inhibition could be of clinical utility in MBC patients overexpressing eIF4E and eIF5. With mTOR inhibitors that target this pathway now in the clinic, these biomarkers may represent new targets for therapeutic intervention, although further independent validation is required.
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24.
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25.
  • Karelin, A. V., et al. (författare)
  • Measurement of electron-positron spectrum in high-energy cosmic rays in the PAMELA experiment
  • 2015
  • Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
  • Konferensbidrag (refereegranskat)abstract
    • At present the existing data on the cosmic ray electron energy spectra in the high energy range are fragmented, and the situation is exacerbated by their small number. In the satellite PAMELA experiment measurements at high energies are carried out by the calorimeter. The experimental data accumulated for more than 8 years of measurements, with the information of the calorimeter, the neutron detector and the scintillation counters made it possible to obtain the total spectrum of high-energy electrons and positrons in energy range 0.3-3 TeV.
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26.
  • Karelin, A. V., et al. (författare)
  • Measurement of the large-scale anisotropy of cosmic rays in the PAMELA experiment
  • 2015
  • Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 101:5, s. 295-298
  • Tidskriftsartikel (refereegranskat)abstract
    • Large-scale anisotropy or so-called sidereal-diurnal wave has been detected in the PAMELA satellite experiment in the time interval of 2006–2014. The magnitude of anisotropy has been measured simultaneously for the Southern and Northern Hemispheres in the equatorial coordinate system. The results confirm the data of ground-based experiments.
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27.
  • Karelin, A. V., et al. (författare)
  • The high energy cosmic ray particle spectra measurements with the PAMELA calorimeter
  • 2016
  • Ingår i: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 275-281
  • Tidskriftsartikel (refereegranskat)abstract
    • Up until now there has been limited, contradictive data on the high energy range of the cosmic ray electron-positron, proton and helium spectra. Due to the limitations of the use of a magnetic spectrometer, over 8 years experimental data was processed using information from a sampling electro-magnetic calorimeter, a neutron detector and scintillator detectors. The use of these devices allowed us to successfully obtain the high energy cosmic ray particle spectra measurements. The results of this study clarify previous findings and greaten our understanding of the origin of cosmic rays.
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28.
  • Koldobskiy, S. A., et al. (författare)
  • Galactic deuteron spectrum measured in PAMELA experiment
  • 2013
  • Ingår i: 23Rd European Cosmic Ray Symposium (And 32Nd Russian Cosmic Ray Conference). - : IOP Publishing.
  • Konferensbidrag (refereegranskat)abstract
    • Results of galactic deuteron spectrum measurement by means of PAMELA apparatus are described. PAMELA is an international experiment developed for antimatter search and measurement of p, He, electron and positron spectra in wide energy range. In addition, PAMELA allows to identify and measure deuteron spectrum at low energies. In this paper deuteron-to-proton ratio and deuteron spectrum are presented.
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29.
  • Koldobskiy, S. A., et al. (författare)
  • Measurement of galactic cosmic-ray deuteron spectrum in the PAMELA experiment
  • 2013
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press. - 1062-8738. ; 77:5, s. 606-608
  • Tidskriftsartikel (refereegranskat)abstract
    • This work presents the results of measuring the deuteron spectrum of Galactic cosmic rays (GCRs) with the PAMELA experiment. The PAMELA is an international experiment. Its main objectives are to search for antimatter and measure proton, helium nuclei, electron, and positron spectra over a wide range of energies. In addition, the experimental setup allows the detection of deuterons and the reconstruction of their spectra at low energies. Cosmic ray deuteron spectrum and the deuteron-proton ratio measured in the PAMELA experiment in the energy range of 50-650 MeV/nucleon are presented below.
  •  
30.
  • Koldobskiy, S., et al. (författare)
  • Measuring the albedo deuteron flux in the PAMELA satellite experiment
  • 2015
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:3, s. 294-297
  • Tidskriftsartikel (refereegranskat)abstract
    • The results of measuring albedo deuteron fluxes in the vicinity of the Earth are presented. The data were obtained in the PAMELA experiment conducted aboard the Resurs DK-1 artificial Earth satellite. High-precision detectors of the instrument setup allow us to identify albedo deuterons and measure their spectra in the energy interval from 70 to 600 MeV/nucleon at altitudes of 350–600 km for different geomagnetic latitudes.
  •  
31.
  • Mayorov, A. G., et al. (författare)
  • Antiprotons of galactic cosmic radiation in the PAMELA experiment
  • 2013
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 602-605
  • Tidskriftsartikel (refereegranskat)abstract
    • A method for antiproton selection against a background of electrons, based on a mathematical model of data classification using variations in interparticle interaction in a calorimeter, and a method for excluding events accompanied by scattering in the inner detectors of a tracking system (which result in errors in the measured trajectory's curvature and charge sign) from analysis are discussed in this paper. Antiproton spectra and antiproton/proton flux ratio at energies of 0.06 to 350 GeV with statistics of events surpassing those in [1] are obtained. The results can be used to create models for the generation and distribution of particles in the Galaxy, and for searching and studying the nature of hypothetical dark matter particles.
  •  
32.
  • Menn, W., et al. (författare)
  • The PAMELA space experiment
  • 2013
  • Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 209-218
  • Tidskriftsartikel (refereegranskat)abstract
    • On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus is comprised of a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail counter scintillator and a neutron detector. The combination of these devices allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV to 100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectra in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (anti-helium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA is investigating phenomena connected with solar and earth physics. After 4 years of operation in flight, PAMELA is now delivering coherent results about spectra and chemical composition of the charged cosmic radiation, allowing scenarios of production and propagation of cosmic rays to be fully established and understood.
  •  
33.
  • Mikhailov, V., et al. (författare)
  • Cosmic ray electron and positron spectra measured with PAMELA
  • 2013
  • Ingår i: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 409:1, s. 012035-
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA experiment is carried out on board of the satellite Resurs DK1 launched on June 15th 2006 on polar orbit (the inclination is 70, the altitude is 350-600 km). The instrument which consists of magnetic spectrometer, silicon-tungsten imaging electromagnetic calorimeter gives a possibility to measure electron and positron fluxes over wide energy range from hundreds MeVs to hundreds GeVs. Measurements made in June 2006- January 2010 are presented and compared with other results and models. Positron spectrum appears to be harder than standard diffusive propagation models predict.
  •  
34.
  • Mocchiutti, E., et al. (författare)
  • Cosmic–ray positron energy spectrum measured by PAMELA
  • 2013
  • Ingår i: Proceedings of the 33rd International Cosmic Rays Conference, ICRC 2013. - : Sociedade Brasileira de Fisica. - 9788589064293
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA satellite borne experiment is designed to study cosmic rays with great accuracy in a wide energy range. One of PAMELA’s main goal is the study of the antimatter component of cosmic rays. The experiment, housed on board the Russian satellite Resurs–DK1, was launched on June 15th 2006 and it is still taking data. In this work we present the measurement of galactic positron energy spectrum in the energy range between 500 MeV and few hundred GeV. 
  •  
35.
  • Mocchiutti, E., et al. (författare)
  • PAMELA and electrons
  • 2011
  • Konferensbidrag (refereegranskat)abstract
    • The 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail counter scintillator and a neutron detector. The combination of these devices allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV-100's GeV) with high statistics. The measurement of the positron to electron fraction and of the electron energy spectrum in order to search for exotic sources, such as dark matter particle annihilations, are within the PAMELA primary scientific goal.
  •  
36.
  • Mocchiutti, E., et al. (författare)
  • Precision studies of cosmic rays with the PAMELA satellite experiment
  • 2009
  • Ingår i: 2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5. - : IEEE. - 9781424439621 ; , s. 2125-2130
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA satellite experiment was launched into low earth orbit on June 15th 2006. The combination of a permanent magnet silicon strip spectrometer, and a silicon-tungsten imaging calorimeter allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - 200 GeV). A primary scientific goal is to search for dark matter particle annihilations by measuring the energy spectra of cosmic ray antiparticles. Latest results from the PAMELA experiment will be reviewed with a particular focus on cosmic ray antiprotons and positrons. The status of PAMELA measurements for other cosmic ray species will also be reviewed.
  •  
37.
  • Mocchiutti, E., et al. (författare)
  • Results from PAMELA
  • 2011
  • Ingår i: NUCL PHYS B-PROC SUP. - : Elsevier BV. ; , s. 243-248
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA satellite experiment was launched into low earth orbit on June 15(th) 2006. The combination of a permanent magnet silicon strip spectrometer and a silicon-tungsten imaging calorimeter allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - several hundred GeV). A primary scientific goal is to search for dark matter particle annihilation by measuring the energy spectra of cosmic ray antiparticles. Latest results from the PAMELA experiment are presented with a particular focus on cosmic ray antiprotons and positrons.
  •  
38.
  • Mocchiutti, E., et al. (författare)
  • The PAMELA space experiment
  • 2009
  • Ingår i: Proceedings of the 44th Rencontres de Moriond - 2009 Electroweak Interactions and Unified Theories, EW 2009. - : Gioi Publishers. ; , s. 317-324
  • Konferensbidrag (refereegranskat)abstract
    • The 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail counter scintillator and a neutron detector. The combination of these devices allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - 100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectrum in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (anti-helium) and testing cosmic-ray propagation models through precise measurements of the anti-particle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA is investigating phenomena connected with solar and earth physics.
  •  
39.
  • Papini, P., et al. (författare)
  • Latest results from PAMELA
  • 2009
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA experiment is a satellite-borne apparatus designed to study charged particles in the cosmic radiation, with a particular focus on antiparticles. The detector is housed on the Resurs-DK1 satellite and it is taking data since June 2006. The main parts of the apparatus are a magnetic spectrometer, which is equipped with a silicon-microstrip tracking system and which is used to measure the rigidity and the charge of particles, and a silicon/tungsten electromagnetic calorimeter which provides particle identification. The main results about the antiparticles component of cosmic rays obtained during the first 500 days of data taking are summarized here.
  •  
40.
  • Picozza, P., et al. (författare)
  • Cosmic ray studies with PAMELA experiment
  • 2011
  • Ingår i: Proceedings of the 14th Lomonosov Conference on Elementary Particle Physics: Particle Physics at the Year of Astronomy. - 9814329673 - 9789814329675 ; , s. 200-206
  • Konferensbidrag (refereegranskat)abstract
    • The instrument PAMELA, in orbit since June 15th, 2006 on board of the Russian satellite Resurs DK1, is daily delivering to ground 16 Gigabytes of data. The apparatus is designed to study charged particles in the cosmic radiation, with a particular focus on antiparticles for searching antimatter and signals of dark matter annihilation. A combination of a magnetic spectrometer and different detectors allows antiparticles to be reliably identified from a large background of other charged particles. New results on the antiproton-to-proton and positron-toall electron ratios over a wideenergy range (1-100 GeV) have been obtained from the PAMELA mission. These data are mainly interpreted in terms of dark matter annihilation or pulsar contribution.
  •  
41.
  • Usoskin, I. G., et al. (författare)
  • Force-field parameterization of the galactic cosmic ray spectrum : Validation for Forbush decreases
  • 2015
  • Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 55:12, s. 2940-2945
  • Tidskriftsartikel (refereegranskat)abstract
    • A useful parametrization of the energy spectrum of galactic cosmic rays (GCR) near Earth is offered by the so-called force-field model which describes the shape of the entire spectrum with a single parameter, the modulation potential. While the usefulness of the force-field approximation has been confirmed for regular periods of solar modulation, it was not tested explicitly for disturbed periods, when GCR are locally modulated by strong interplanetary transients. Here we use direct measurements of protons and alpha-particles performed by the PAMELA space-borne instrument during December 2006, including a major Forbush decrease, in order to directly test the validity of the force-field parameterization. We conclude that (1) The force-field parametrization works very well in describing the energy spectra of protons and alpha-particles directly measured by PAMELA outside the Earths atmosphere; (2) The energy spectrum of GCR can be well parameterized by the force-field model also during a strong Forbush decrease; (3) The estimate of the GCR modulation parameter, obtained using data from the world-wide neutron monitor network, is in good agreement with the spectra directly measured by PAMELA during the studied interval. This result is obtained on the basis of a single event analysis, more events need to be analyzed.
  •  
42.
  • Zamora, Juan Carlos, et al. (författare)
  • Considerations and consequences of allowing DNA sequence data as types of fungal taxa
  • 2018
  • Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
  • Tidskriftsartikel (refereegranskat)abstract
    • Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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