SwePub - sökning: WFRF:(Carlson Jan)

Numrering	Referens	Omslagsbild	Hitta
1.	2019 Tidskriftsartikel (refereegranskat)
2.	Burman, Joachim, et al. (författare) Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis : the Swedish experience 2014 Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - London, United Kingdom : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X. ; 85:10, s. 1116-1121 Tidskriftsartikel (refereegranskat)abstract Background: Autologous haematopoietic stem cell transplantation (HSCT) is a viable option for treatment of aggressive multiple sclerosis (MS). No randomised controlled trial has been performed, and thus, experiences from systematic and sustained follow-up of treated patients constitute important information about safety and efficacy. In this observational study, we describe the characteristics and outcome of the Swedish patients treated with HSCT for MS.Methods: Neurologists from the major hospitals in Sweden filled out a follow-up form with prospectively collected data. Fifty-two patients were identified in total; 48 were included in the study and evaluated for safety and side effects; 41 patients had at least 1 year of follow-up and were further analysed for clinical and radiological outcome. In this cohort, 34 patients (83%) had relapsing-remitting MS, and mean follow-up time was 47 months.Results: At 5 years, relapse-free survival was 87%; MRI event-free survival 85%; expanded disability status scale (EDSS) score progression-free survival 77%; and disease-free survival (no relapses, no new MRI lesions and no EDSS progression) 68%. Presence of gadolinium-enhancing lesions prior to HSCT was associated with a favourable outcome (disease-free survival 79% vs 46%, p=0.028). There was no mortality. The most common long-term side effects were herpes zoster reactivation (15%) and thyroid disease (8.4%).Conclusions: HSCT is a very effective treatment of inflammatory active MS and can be performed with a high degree of safety at experienced centres.
3.	Littorin, Bengt, et al. (författare) Family characteristics and life events before the onset of autoimmune type 1 diabetes in young adults : A nationwide study 2001 Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 24:6, s. 1033-1037 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nationwide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cells and/or to GAD65 were compared with age- and sex-matched control subjects via questionnaire. The questionnaire covered diabetes heredity, social environment, educational level, and life events experienced during the 12 months before diagnosis. RESULTS - The rate of response was 82% for the diabetic patients and 65% for the control subjects. Questionnaires from 349 diabetic patients and 979 control subjects were considered. Diabetes in relatives was more frequent in the patients (odds ratio [OR] 2.6) who were born in Sweden and whose mothers were of Swedish origin. No major stress factors were detected in the diabetic patients, however, in comparison with the control subjects, the diabetic patients had experienced fewer conflicts with their parents and had less often broken contacts with friends. CONCLUSIONS - Young adults with recent-onset type 1 diabetes were more exposed to heredity for diabetes, but no major prediabetic stress factors were detected. Our study does not directly support the concept that psychosocial stressful life events are involved in the development of autoimmune type 1 diabetes in young adults.
4.	Machowcz, Rafal, et al. (författare) Allogeneic Hematopoietic Stem Cell Transplantation Provides Cure for Adult Patients with Hemophagocytic Lymphohistiocytosis (HLH) : A Retrospective Study of The Chronic Malignancies and Inborn ErrorsWorking Parties (CMWP and IEWP) of The EBMT 2017 Ingår i: Pediatric Blood & Cancer. - 1545-5009 .- 1545-5017. ; 64:S2, s. S23-S24 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
5.	Machowicz, Rafal, et al. (författare) Allogeneic hematopoietic stem cell transplantation for adult HLH : a retrospective study by the chronic malignancies and inborn errors working parties of EBMT 2022 Ingår i: Bone Marrow Transplantation. - : Springer Nature. - 0268-3369 .- 1476-5365. ; 57:5, s. 817-823 Tidskriftsartikel (refereegranskat)abstract Hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) is a rare syndrome of potentially fatal, uncontrolled hyperinflammation. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is indicated in primary, recurrent or progressive HLH, but information about its outcomes in the adult population is limited. We obtained data about 87 adult (>= 18 years of age) patients retrospectively reported to the EBMT. The median survival time was 13.9 months. The three and five-year overall survival (OS) was 44% (95% CI 33-54%). Among 39 patients with a follow-up longer than 15 months, only three died. Relapse rate was 21% (95% CI 13-30%), while NRM reached 36% (95% CI 25-46%). Younger patients (<30 years of age) had better prognosis, with an OS of 59% (95% CI 45-73%) at three and five years vs 23% (95% CI 8-37%) for older ones. No difference in survival between reduced and myeloablative conditioning was found. To our knowledge, this is the largest report of adult HLH patients who underwent allo-HSCT. Patients who survive the first period after this procedure can expect a long disease-free survival. Both reduced intensity and myeloablative conditioning have therapeutic potential in adult HLH.
6.	Accelerating digital transformation : 10 years of software center 2022 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract This book celebrates the 10-year anniversary of Software Center (a collaboration between 18 European companies and five Swedish universities) by presenting some of the most impactful and relevant journal or conference papers that researchers in the center have published over the last decade.The book is organized around the five themes around which research in Software Center is organized, i.e. Continuous Delivery, Continuous Architecture, Metrics, Customer Data and Ecosystems Driven Development, and AI Engineering. The focus of the Continuous Delivery theme is to help companies to continuously build high quality products with the right degree of automation. The Continuous Architecture theme addresses challenges that arise when balancing the need for architectural quality and more agile ways of working with shorter development cycles. The Metrics theme studies and provides insight to understand, monitor and improve software processes, products and organizations. The fourth theme, Customer Data and Ecosystem Driven Development, helps companies make sense of the vast amounts of data that are continuously collected from products in the field. Eventually, the theme of AI Engineering addresses the challenge that many companies struggle with in terms of deploying machine- and deep-learning models in industrial contexts with production quality. Each theme has its own part in the book and each part has an introduction chapter and then a carefully selected reprint of the most important papers from that theme.This book mainly aims at researchers and advanced professionals in the areas of software engineering who would like to get an overview about the achievement made in various topics relevant for industrial large-scale software development and management – and to see how research benefits from a close cooperation between industry and academia.
7.	Bosch, Jan, 1967, et al. (författare) Accelerating digital transformation: 10 years of software center 2022 Bok (övrigt vetenskapligt/konstnärligt)abstract This book celebrates the 10-year anniversary of Software Center (a collaboration between 18 European companies and five Swedish universities) by presenting some of the most impactful and relevant journal or conference papers that researchers in the center have published over the last decade. The book is organized around the five themes around which research in Software Center is organized, i.e. Continuous Delivery, Continuous Architecture, Metrics, Customer Data and Ecosystems Driven Development, and AI Engineering. The focus of the Continuous Delivery theme is to help companies to continuously build high quality products with the right degree of automation. The Continuous Architecture theme addresses challenges that arise when balancing the need for architectural quality and more agile ways of working with shorter development cycles. The Metrics theme studies and provides insight to understand, monitor and improve software processes, products and organizations. The fourth theme, Customer Data and Ecosystem Driven Development, helps companies make sense of the vast amounts of data that are continuously collected from products in the field. Eventually, the theme of AI Engineering addresses the challenge that many companies struggle with in terms of deploying machine- and deep-learning models in industrial contexts with production quality. Each theme has its own part in the book and each part has an introduction chapter and then a carefully selected reprint of the most important papers from that theme. This book mainly aims at researchers and advanced professionals in the areas of software engineering who would like to get an overview about the achievement made in various topics relevant for industrial large-scale software development and management - and to see how research benefits from a close cooperation between industry and academia.
8.	Celen, Yelda Turgut, et al. (författare) Impact of Gender on Incident Diabetes Mellitus in Obstructive Sleep Apnea: A 16-Year Follow-Up 2010 Ingår i: Journal of clinical sleep medicine. - 1550-9389. ; 6:3, s. 244-250 Tidskriftsartikel (refereegranskat)abstract STUDY OBJECTIVE: To address the influence of gender and obstructive sleep apnea (OSA) on development of diabetes mellitus (DM) in a sleep clinic cohort. DESIGN: A longitudinal observational study. PARTICIPANTS: A consecutive middle-aged (30-69 years) sleep clinic cohort from 1991 (n=318; 254 men, 64 women) with eligible baseline characteristics, clinical charts, and information from the Swedish Hospital Discharge Registry were identified. Ten individuals with DM at baseline and 47 patients who died during the follow-up period were excluded. MEASUREMENTS: The remaining 261 subjects were asked to complete a postal questionnaire regarding concomitant diseases including DM, diagnosed by a physician. RESULTS: In total, 168 patients (64.4%) replied. The incidence of DM was 24.9% in patients with OSA (overnight oxygen desaturations > or =30 in 1991) compared with 10.8% in subjects without OSA (p = 0.020). New-onset DM in men was 19.1% in OSA vs. 11.1% in non-OSA (n.s.), while the corresponding values in women were 50.0% in OSA and 9.5% in non-OSA (p = 0.022). In a multivariate analysis, DM was predicted by OSA in women with an odds ratio (OR) of 11.8, but not by age, body mass index (BMI) at baseline, or weight change at followup. In men, only BMI (OR 1.16) predicted DM. CONCLUSION: The contribution of OSA to DM development seems to be gender-dependent and higher in women than in men.
9.	Peker, Yüksel, 1961, et al. (författare) Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up 2006 Ingår i: Eur Respir J.. ; 28:3 Tidskriftsartikel (refereegranskat)abstract An increased incidence of cardiovascular disease has previously been reported in middle-aged males during a follow-up period of 7 yrs. The aim of the present study was to address the incidence of coronary artery disease (CAD) in a larger sample without any heart disease at baseline. The population comprised 308 snorers (245 males and 63 females) with a mean+/-sd age of 49.0+/-9.9 yrs in 1991. Data were collected via the Swedish Hospital Discharge Register, National Cause of Death Registry, clinical charts and questionnaires. Over 7 yrs, CAD was observed in 17 (16.2%) of 105 patients with obstructive sleep apnoea (OSA; overnight (6 h) oxygen desaturations >/=30 events) compared with 11 (5.4%) of 203 snorers without OSA. OSA diagnosis at baseline was associated with an increased risk of development of CAD in a multivariate model. In the OSA group, CAD was confirmed in 16 (24.6%) of 65 incompletely treated patients compared with one (3.9%) of 26 efficiently treated subjects. Efficient treatment of OSA reduced this risk. It is concluded that middle-aged sleep apnoeics are at high risk of developing coronary artery disease if they are not treated efficiently, which should be considered in cardiovascular disease prevention models.
10.	Raj, Kavita, et al. (författare) Family Mismatched Allogeneic Stem Cell Transplantation for Myelofibrosis : Report from the Chronic Malignancies Working Party of European Society for Blood and Marrow Transplantation 2019 Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 25:3, s. 522-528 Tidskriftsartikel (refereegranskat)abstract This analysis included 56 myelofibrosis (MF) patients transplanted from family mismatched donor between 2009 and 2015 enrolled in the European Society for Blood and Marrow Transplantation database. The median age was 57 years (range, 38 to 72); 75% had primary MF and 25% had secondary MF. JAK2 V617F was mutated in 61%. Donors were HLA mismatched at 2 or more loci. Stem cells were sourced from bone marrow in 66% and peripheral blood in 34%. The median CD34(+) cell dose was 4.8 x 10(6)/kg (range, 1.7 to 22.9; n = 43). Conditioning was predominantly myeloablative in 70% and reduced intensity in the remainder. Regimens were heterogeneous with thiotepa, busulfan, fludarabine, and post-transplant cyclophosphamide used in 59%. The incidence of neutrophil engraftment by 28 days was 82% (range, 70% to 93%), at a median of 21 days (range, 19 to 23). At 2 years the cumulative incidence of primary graft failure was 9% (95% CI 1% to 16%) and secondary graft failure was 13% (95% CI 4% to 22%). The cumulative incidence of acute graft-versus-host disease (GVHD) grades II to IV and Ill to IV was 28% (95% CI 16% to 40%) and 9% (95% CI 2% to 17%) at 100 days. The cumulative incidence of chronic GVHD at 1 year was 45% (95% CI 32% to 58%), but the cumulative incidence of death without chronic GVHD by 1 year was 20% (95% CI 10% to 31%). With a median follow-up of 32 months, the 1- and 2-year overall survival was 61% (95% CI 48% to 74%) and 56% (95% CI 41% to 70%), respectively. The 1- and 2- year progression-free survival was 58% (95% CI 45% to 71%) and 43% (95% CI 28% to 58%), respectively, with a 2-year cumulative incidence of relapse of 19% 95% CI 7% to 31%). The 2-year nonrelapse mortality was 38% (95% CI 24% to 51%). This retrospective study of MF allo-SCT using family mismatched donors demonstrated feasibility of the approach, timely neutrophil engraftment in over 80% of cases, and acceptable overall and progression-free survival rates with relapse rates not dissimilar to the unrelated donor setting. However, strategies to minimize the risk of graft failure and the relatively high nonrelapse mortality need to be used, ideally in a multicenter prospective fashion.
11.	Sedova, Ksenia A, et al. (författare) Terminal T-wave inversion predicts reperfusion tachyarrhythmias in STEMI 2022 Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 1532-8430 .- 0022-0736. ; 71, s. 28-31 Tidskriftsartikel (refereegranskat)abstract INTRODUCTION: A reliable electrocardiographic predictor of ventricular fibrillation (VF) in patients with ST elevation myocardial infarction (STEMI) is lacking so far. Previous experimental/simulation study suggested a terminal T-wave inversion (TTWI) in ischemia-related ECG leads corresponding to anterior infarct localization as an independent predictor of reperfusion VF (rVF). This T-wave characteristic has never been tested as a rVF predictor in clinical settings. The aim of this study was to test if terminal T-wave inversion (TTWI) at admission ECG (before reperfusion) can serve as a predictor of ventricular fibrillation during reperfusion (rVF) in patients with anterior STEMI undergoing primary PCI.METHODS AND RESULTS: Study population included consecutive patients with anterior infarct localization admitted for primary PCI (n = 181, age 65 [57; 76] years, 66% male). Of those, 14 patients had rVF (rVF group, age 59 [47; 76] years, 64% male) and patients without rVF comprised the No-rVF group (n = 167, age 65 [57; 76] years, 66% male). Association of TTWI with rVF was analyzed using logistic regression analysis adjusted for relevant clinical and electrocardiographic covariates. The prevalence of TTWI in rVF group was 62% comparing to 23% in the No-rVF group, p = 0.005. TTWI was associated with increased risk of rVF (OR 5.51; 95% CI 1.70-17.89; p = 0.004) and remained a significant predictor after adjustment for age, gender, history of MI prior to index admission, VF before reperfusion, Tpeak-Tend, maximal ST elevation, and QRS duration (OR 23.49; 95% CI 3.14-175.91; p = 0.002).CONCLUSIONS: The terminal T-wave inversion in anterior leads before PCI independently predicted rVF in patients with anterior MI thus confirming the previous experimental/simulation findings.
12.	Silfverberg, Thomas, et al. (författare) Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study 2023 Ingår i: Journal of Neurology Neurosurgery and Psychiatry. - : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X. Tidskriftsartikel (refereegranskat)abstract BackgroundA growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare.MethodsWe assessed 231 patients and the final analysis included 174 RRMS patients who were treated with aHSCT in Sweden before 1 January 2020. Efficacy was evaluated by performing a retrospective analysis of prospectively collected data from the Swedish MS registry. Procedure-related safety was assessed by analysing data from electronic patient records covering a period of 100 days following aHSCT.ResultsWith a median follow-up time of 5.5 (IQR: 3.4-7.5) years, the Kaplan-Meier estimate for no evidence of disease activity was 73% (95% CI 66% to 81%) at 5 years and 65% (95% CI 57% to 75%) at 10 years. Out of the 149 patients with baseline disability, 80 (54%) improved, 55 (37%) were stable and 14 (9%) deteriorated. The mean number of adverse events per patient was 1.7 (& PLUSMN;SD: 1.5) for grade 3 events and 0.06 (& PLUSMN;SD: 0.3) for grade 4 events. Febrile neutropenia was the most common adverse event, affecting 68% of patients. There was no treatment-related mortality.ConclusionsTreatment with aHSCT for RRMS is associated with freedom from disease activity in a majority of patients, with acceptable adverse events. This procedure should be considered a standard of care for patients with highly active RRMS.
13.	Abdo, A. A., et al. (författare) A Population of Gamma-Ray Millisecond Pulsars Seen with the Fermi Large Area Telescope 2009 Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 325:5942, s. 848-852 Tidskriftsartikel (refereegranskat)abstract Pulsars are born with subsecond spin periods and slow by electromagnetic braking for several tens of millions of years, when detectable radiation ceases. A second life can occur for neutron stars in binary systems. They can acquire mass and angular momentum from their companions, to be spun up to millisecond periods and begin radiating again. We searched Fermi Large Area Telescope data for pulsations from all known millisecond pulsars (MSPs) outside of globular clusters, using rotation parameters from radio telescopes. Strong gamma-ray pulsations were detected for eight MSPs. The gamma-ray pulse profiles and spectral properties resemble those of young gamma-ray pulsars. The basic emission mechanism seems to be the same for MSPs and young pulsars, with the emission originating in regions far from the neutron star surface.
14.	Abdo, A. A., et al. (författare) Fermi LAT Observation of Diffuse Gamma Rays Produced Through Interactions Between Local Interstellar Matter and High-energy Cosmic Rays 2009 Ingår i: Astrophysical Journal Supplement Series. - 0067-0049 .- 1538-4365. ; 703:2, s. 1249-1256 Tidskriftsartikel (refereegranskat)abstract Observations by the Large Area Telescope (LAT) on the Fermi mission of diffuse γ-rays in a mid-latitude region in the third quadrant (Galactic longitude l from 200° to 260° and latitude \|b\| from 22° to 60°) are reported. The region contains no known large molecular cloud and most of the atomic hydrogen is within 1 kpc of the solar system. The contributions of γ-ray point sources and inverse Compton scattering are estimated and subtracted. The residual γ-ray intensity exhibits a linear correlation with the atomic gas column density in energy from 100 MeV to 10 GeV. The measured integrated γ-ray emissivity is (1.63 ± 0.05) × 10-26 photons s-1sr-1 H-atom-1 and (0.66 ± 0.02) × 10-26 photons s-1sr-1 H-atom-1 above 100 MeV and above 300 MeV, respectively, with an additional systematic error of ~10%. The differential emissivity from 100 MeV to 10 GeV agrees with calculations based on cosmic ray spectra consistent with those directly measured, at the 10% level. The results obtained indicate that cosmic ray nuclei spectra within 1 kpc from the solar system in regions studied are close to the local interstellar spectra inferred from direct measurements at the Earth within ~10%.
15.	Abdo, A. A., et al. (författare) Measurement of the Cosmic Ray e(+)+e(-) Spectrum from 20 GeV to 1 TeV with the Fermi Large Area Telescope 2009 Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:Article number: 181101 Tidskriftsartikel (refereegranskat)abstract Designed as a high-sensitivity gamma-ray observatory, the Fermi Large Area Telescope is also an electron detector with a large acceptance exceeding 2 m(2) sr at 300 GeV. Building on the gamma-ray analysis, we have developed an efficient electron detection strategy which provides sufficient background rejection for measurement of the steeply falling electron spectrum up to 1 TeV. Our high precision data show that the electron spectrum falls with energy as E-3.0 and does not exhibit prominent spectral features. Interpretations in terms of a conventional diffusive model as well as a potential local extra component are briefly discussed.
16.	Abdo, A. A., et al. (författare) The Fermi Gamma-Ray Space Telescope Discovers the Pulsar in the Young Galactic Supernova Remnant CTA 1 2008 Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 322:5905, s. 1218-1221 Tidskriftsartikel (refereegranskat)abstract Energetic young pulsars and expanding blast waves [ supernova remnants (SNRs)] are the most visible remains after massive stars, ending their lives, explode in core-collapse supernovae. The Fermi Gamma- Ray Space Telescope has unveiled a radio quiet pulsar located near the center of the compact synchrotron nebula inside the supernova remnant CTA 1. The pulsar, discovered through its gamma- ray pulsations, has a period of 316.86 milliseconds and a period derivative of 3.614 x 10(-13) seconds per second. Its characteristic age of 10(4) years is comparable to that estimated for the SNR. We speculate that most unidentified Galactic gamma- ray sources associated with star- forming regions and SNRs are such young pulsars.
17.	Ackermann, M., et al. (författare) Fermi LAT observations of cosmic-ray electrons from 7 GeV to 1 TeV 2010 Ingår i: PHYSICAL REVIEW D. - 1550-7998. ; 82:9, s. 092004- Tidskriftsartikel (refereegranskat)abstract We present the results of our analysis of cosmic-ray electrons using about 8 x 10(6) electron candidates detected in the first 12 months on-orbit by the Fermi Large Area Telescope. This work extends our previously published cosmic-ray electron spectrum down to 7 GeV, giving a spectral range of approximately 2.5 decades up to 1 TeV. We describe in detail the analysis and its validation using beam-test and on-orbit data. In addition, we describe the spectrum measured via a subset of events selected for the best energy resolution as a cross-check on the measurement using the full event sample. Our electron spectrum can be described with a power law proportional to E-3.08+/-0.05 with no prominent spectral features within systematic uncertainties. Within the limits of our uncertainties, we can accommodate a slight spectral hardening at around 100 GeV and a slight softening above 500 GeV.
18.	Andres, E., et al. (författare) Observation of atmospheric neutrino events with the AMANDA experiment 2000 Ingår i: Proceedings of the 17th International Workshop on Weak Interactions and Neutrinos. - : World Scientific. - 9810240821 ; , s. 258-262 Konferensbidrag (refereegranskat)
19.	Antoni, Gunnar, et al. (författare) In Vivo Visualization of Amyloid Deposits in the Heart with C-11-PIB and PET 2013 Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 54:2, s. 213-220 Tidskriftsartikel (refereegranskat)abstract Cardiac amyloidosis is a differential diagnosis in heart failure and is associated with high mortality. There is currently no noninvasive imaging test available for specific diagnosis. N-[methyl-C-11]2-(4'-methylamino-phenyl)-6-hydroxybenzothiazole (C-11-PIB) PET is used in the evaluation of brain amyloidosis. We evaluated the potential use of C-11-PIB PET in systemic amyloidosis affecting the heart. Methods: Patients (n = 10) diagnosed with systemic amyloidosis-including heart involvement of either monoclonal immunoglobulin light-chain (AL) or transthyretin (ATTR) type- and healthy volunteers (n = 5) were investigated with PET/CT using C-11-PIB to study cardiac amyloid deposits and with C-11-acetate to measure myocardial blood flow to study the impact of global and regional perfusion on PIB retention. Results: Myocardial C-11-PIB uptake was visually evident in all patients 15-25 min after injection and was not seen in any volunteer. A significant difference in C-11-PIB retention in the heart between patients and healthy controls was found. The data indicate that myocardial amyloid deposits in patients diagnosed with systemic amyloidosis could be visualized with C-11-PIB. No correlation between C-11-PIB retention index and myocardial blood flow as measured with C-11-acetate was found on the global level, whereas a positive correlation on the segmental level was seen in a single patient. Conclusion: C-11-PIB and PET could be a method to study systemic amyloidosis of type AL and ATTR affecting the heart and should be investigated further both as a diagnostic tool and as a noninvasive method for treatment follow-up.
20.	Astermark, Jan, et al. (författare) Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. 2006 Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 108:12, s. 3739-3745 Tidskriftsartikel (refereegranskat)abstract The HLA class I/II alleles and the tumor necrosis factor alpha (TNFA) locus are closely linked in the MHC complex. We have characterized the causative factor VIII mutation, HLA alleles as well as 4 polymorphisms (-827C > T, -308G > A, -238A > G, and 670A > G) in the TNFA gene in 164 patients (124 severe, 26 moderate, and 14 mild) in 78 families with hemophilia A enrolled in the Malmo International Brother Study (MIBS). Inhibitors were identified in 77.8% of patients with a single haplotype (Hap 2) and 72.7% of the patients with the TNFA -308 A/A genotype within this haplotype compared with 39.70/6 for TNFA -308 G/G patients and 46.9% for TNFA -308 G/A heterozygotes (OR 4.0; 95% CI, 1.4-11.5; P = .008). The association between the -308 A/A genotype and inhibitors was enhanced in subgroups of patients with severe hemophilia (OR 19.2; 95% CI 2.4-156.5; P < .001) and with inversions (n = 75; OR, 11.8; 95% CI, 1.3-105.1; P = .013). Associations were found for the HLA A26 and B44 alleles, but these were not consistent in the subgroup analysis. Our data imply that the TNFA -308G > A polymorphism within Hap 2 is a useful marker and potential modulator of the immune response to replacement therapy in patients with hemophilia.
21.	Atwood, W. B., et al. (författare) THE LARGE AREA TELESCOPE ON THE FERMI GAMMA-RAY SPACE TELESCOPE MISSION 2009 Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 697:2, s. 1071-1102 Tidskriftsartikel (refereegranskat)abstract The Large Area Telescope (Fermi/LAT, hereafter LAT), the primary instrument on the Fermi Gamma-ray Space Telescope (Fermi) mission, is an imaging, wide field-of-view (FoV), high-energy gamma-ray telescope, covering the energy range from below 20 MeV to more than 300 GeV. The LAT was built by an international collaboration with contributions from space agencies, high-energy particle physics institutes, and universities in France, Italy, Japan, Sweden, and the United States. This paper describes the LAT, its preflight expected performance, and summarizes the key science objectives that will be addressed. On-orbit performance will be presented in detail in a subsequent paper. The LAT is a pair-conversion telescope with a precision tracker and calorimeter, each consisting of a 4 x 4 array of 16 modules, a segmented anticoincidence detector that covers the tracker array, and a programmable trigger and data acquisition system. Each tracker module has a vertical stack of 18 (x, y) tracking planes, including two layers (x and y) of single-sided silicon strip detectors and high-Z converter material (tungsten) per tray. Every calorimeter module has 96 CsI(Tl) crystals, arranged in an eight-layer hodoscopic configuration with a total depth of 8.6 radiation lengths, giving both longitudinal and transverse information about the energy deposition pattern. The calorimeter's depth and segmentation enable the high-energy reach of the LAT and contribute significantly to background rejection. The aspect ratio of the tracker (height/width) is 0.4, allowing a large FoV (2.4 sr) and ensuring that most pair-conversion showers initiated in the tracker will pass into the calorimeter for energy measurement. Data obtained with the LAT are intended to (1) permit rapid notification of high-energy gamma-ray bursts and transients and facilitate monitoring of variable sources, (2) yield an extensive catalog of several thousand high-energy sources obtained from an all-sky survey, (3) measure spectra from 20 MeV to more than 50 GeV for several hundred sources, (4) localize point sources to 0.3-2 arcmin, (5) map and obtain spectra of extended sources such as SNRs, molecular clouds, and nearby galaxies, (6) measure the diffuse isotropic gamma-ray background up to TeV energies, and (7) explore the discovery space for dark matter.
22.	Axelsson, Jakob, et al. (författare) Towards the architecture of a decision support ecosystem for system component selection 2017 Ingår i: 11th Annual IEEE International Systems Conference, SysCon 2017 - Proceedings. - 9781509046225 - 9781509046232 Konferensbidrag (refereegranskat)abstract When developing complex software-intensive systems, it is nowadays common practice to base the solution partly on existing software components. Selecting which components to use becomes a critical decision in development, but it is currently not well supported through methods and tools. This paper discusses how a decision support system for this problem could benefit from a software ecosystem approach, where participants share knowledge across organizations both through reuse of analysis models, and through partially disclosed past decision cases. We show how the ecosystem architecture becomes fundamental to deal with efficient knowledge sharing, while respecting constraints on integrity of intellectual property. A concrete architecture proposal is outlined, which is a web-based distributed system-of-systems. Experiences of a proof-of-concept implementation are also described.
23.	Barkefors, Irmeli, et al. (författare) Endothelial cell migration in stable gradients of vascular endothelial growth factor A and fibroblast growth factor 2 : effects on chemotaxis and chemokinesis 2008 Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 283:20, s. 13905-13912 Tidskriftsartikel (refereegranskat)abstract Gradients of secreted signaling proteins guide growing blood vessels during both normal and pathological angiogenesis. However, the mechanisms by which endothelial cells integrate and respond to graded distributions of chemotactic factors are still poorly understood. We have in this study investigated endothelial cell migration in response to hill-shaped gradients of vascular endothelial growth factor A (VEGFA) and fibroblast growth factor 2 (FGF2) using a novel microfluidic chemotaxis chamber (MCC). Cell migration was scored at the level of individual cells using time-lapse microscopy. A stable gradient of VEGFA165 ranging from 0 to 50 ng/ml over a distance of 400 microm was shown to strongly induce chemotaxis of endothelial cells of different vascular origin. VEGFA121, unable to bind proteoglycan and neuropilin coreceptors, was also shown to induce chemotaxis in this setup. Furthermore, a gradient of FGF2 was able to attract venular but not arterial endothelial cells, albeit less efficiently than VEGFA165. Notably, constant levels of VEGFA165, but not of FGF2, were shown to efficiently reduce chemokinesis. Systematic exploration of different gradient shapes led to the identification of a minimal gradient steepness required for efficient cell guidance. Finally, analysis of cell migration in different regions of the applied gradients showed that chemotaxis is reduced when cells reach the high end of the gradient. Our findings suggest that chemotactic growth factor gradients may instruct endothelial cells to shift toward a nonmigratory phenotype when approaching the growth factor source.
24.	Bilic, Damir, et al. (författare) Detecting inconsistencies in annotated product line models 2020 Ingår i: SPLC '20: Proceedings of the 24th ACM Conference on Systems and Software Product Line: Volume A. - New York, NY, USA : Association for Computing Machinery. - 9781450375696 ; , s. 252-262 Konferensbidrag (refereegranskat)abstract Model-based product line engineering applies the reuse practices from product line engineering with graphical modeling for the specification of software intensive systems. Variability is usually described in separate variability models, while the implementation of the variable systems is specified in system models that use modeling languages such as SysML. Most of the SysML modeling tools with variability support, implement the annotation-based modeling approach. Annotated product line models tend to be error-prone since the modeler implicitly describes every possible variant in a single system model. To identifying variability-related inconsistencies, in this paper, we firstly define restrictions on the use of SysML for annotative modeling in order to avoid situations where resulting instances of the annotated model may contain ambiguous model constructs. Secondly, inter-feature constraints are extracted from the annotated model, based on relations between elements that are annotated with features. By analyzing the constraints, we can identify if the combined variability- and system model can result in incorrect or ambiguous instances. The evaluation of our prototype implementation shows the potential of our approach by identifying inconsistencies in the product line model of our industrial partner which went undetected through several iterations of the model.
25.	Björkbacka, Harry, et al. (författare) Associations Between Human Leukocyte Antigen (HLA) Genotype And Acute Myocardial Infarction 2009 Ingår i: Atherosclerosis Supplements. - 1567-5688. ; 10:2, s. 953-953 Konferensbidrag (refereegranskat)
26.	Björkbacka, Harry, et al. (författare) Weak associations between human leucocyte antigen genotype and acute myocardial infarction 2010 Ingår i: Journal of Internal Medicine. - : Blackwell Publishing Ltd. - 0954-6820 .- 1365-2796. ; 268:1, s. 50-58 Tidskriftsartikel (refereegranskat)abstract Objectives: Human leucocyte antigens (HLAs) are polymorphic molecules involved in antigen presentation. Associations between HLA type and autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis, are well established but the potential association of genetic variation affecting antigen presentation with cardiovascular disease has not been systematically investigated in large cohorts. The importance of such studies is stressed by recent experimental findings of an involvement of autoimmunity in the atherosclerotic disease process. Results: An SSP-PCR method was used for HLA genotyping to determine associations of HLA-DRB1, -DQA1 and -DQB1 with cardiovascular disease in a population-based cohort of 1188 acute myocardial infarction (AMI) patients and 1191 matched healthy controls. The HLA-DRB10101 allele, as well as the HLA-DRB10101-DQA101-DQB105 haplotype, was found to be associated with increased risk for AMI (OR 1.24; 95% CI 1.00–1.54 for both). In contrast, the DRB107 and DQA02 alleles (OR 0.78; 95% CI 0.65–0.95 for both), as well as the DRB107-DQA02-DQB*02 haplotype, conferred protection (OR 0.79; 95% CI 0.63–0.98). An HLA risk score taking each individual’s both haplotypes into account was higher amongst cases (2.43 ± 0.92 vs. 2.29 ± 0.95, P = 0.001). The association between HLA risk score and AMI was independent of other cardiovascular riskfactors assessed. Conclusions: This study demonstrates that the associations between HLA-DRB1 and DQA1 loci and cardiovascular disease exists but that they are considerably weaker than those previously reported for other diseases with an established autoimmune aetiology such as type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis.
27.	Boezio, M., et al. (författare) The first year in orbit of the pamela experiment 2007 Ingår i: Proceedings of the 30th International Cosmic Ray Conference, ICRC 2007. - : Universidad Nacional Autonoma de Mexico. ; , s. 99-102 Konferensbidrag (refereegranskat)abstract On the 15th of June 2006, the PAMELA experiment mounted on the Resurs DK1 satellite, was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. PAMELA is a satellite-borne apparatus designed to study charged particles in the cosmic radiation, to investigate the nature of dark matter, measuring the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved, and to search for antinuclei with unprecedented sensitivity. The PAMELA apparatus comprises a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. We will present the status of the apparatus after one year in orbit. Furthermore, we will discuss the PAMELA in-flight performances.
28.	Bohlin, Markus, et al. (författare) Bounding Shared-Stack Usage in Systems with Offsets and Precedences 2008 Ingår i: ECRTS 2008: PROCEEDINGS OF THE 20TH EUROMICRO CONFERENCE ON REAL-TIME SYSTEMS. - 9780769532981 ; , s. 276-285 Konferensbidrag (refereegranskat)abstract The paper presents two novel methods to bound the stack memory used in preemptive, shared stack, real-time systems. The first method is based on branch-and-bound search for possible preemption patterns, and the second one approximates the first in polynomial time. The work extends previous methods by considering a more general task-model, in which all tasks can share the same stack. In addition, the new methods account for precedence and offset relations. Thus, the methods give tight bounds for a large set of realistic systems. The methods have been implemented and a comprehensive evaluation, comparing our new methods against each other and against existing methods, is presented. The evaluation shows that our exact method can significantly reduce the amount of stack memory needed.
29.	Bohlin, Markus, et al. (författare) Safe Shared Stack Bounds in Systems with Offsets and Precedences 2008 Rapport (övrigt vetenskapligt/konstnärligt)abstract The paper presents two novel methods to bound the stack memory used in preemptive, shared stack, real-time systems. The first method is based on branch-and-bound search for possible preemption patterns, and the second one approximates the first in polynomial time. The work extends previous methods by considering a more general taskmodel, in which all tasks can share the same stack. In addition, the new methods account for precedence and offset relations. Thus, the methods give tight bounds for a large set of realistic systems. The methods have been implemented and a comprehensive evaluation, comparing our new methods against each other and against existing methods, is presented. The evaluation shows that our exact method can significantly reduce the amount of stack memory needed. In our simulations, a decrease in the order of 40% was typical, with a runtime in the order of seconds. Our polynomial approximation consequently yields about 20% higher bound than the exact method.
30.	Borde, Etienne, et al. (författare) Automatic Synthesis and Adaption of Gray-box Components for Embedded Systems - Reuse vs. Optimization 2011 Ingår i: Proceedings - International Computer Software and Applications Conference. - 9780769544595 ; , s. 224-229 Konferensbidrag (refereegranskat)abstract Component-based development of embedded systems has been suggested as a means to increase development efficiency by, for example, facilitating reuse. However, the specifics of the embedded systems domain also raise some particular difficulties when applying this approach. For example, when glue code is automatically produced from an architectural specification, a systematic approach where fully reusable code is generated for all entities in the system, can lead to unaffordable overhead in embedded systems with severe resource limitations and temporal constraints. If, on the other hand, highly optimized code is produced by taking advantage of the specific context in which each component is used, then the generated code is not reusable in other contexts, and the potential benefits of component-based development are not fully exploited. In this paper, we present a component-based framework that permits a more detailed trade-off between optimization and reusability, by automating the integration of components for which the software designer can specify the desired reuse potential. Depending on this specification, the integration code is either reused and adapted, or completely optimized.
31.	Borde, Etienne, et al. (författare) PRIDE - an Environment for Component-based Development of Distributed Real-time Embedded Systems 2011 Ingår i: 9th Working IEEE/IFIP Conference on Software Architecture. - Los Alamitos : IEEE Computer Society. - 9780769543512 ; , s. 351-354 Konferensbidrag (refereegranskat)abstract Settling down the software architecture for embedded system is a complex and time consuming task. Specific concerns that are generally issued from implementation details must be captured in the software architecture and assessed to ensure system correctness. The matter is further complicated by the inherent complexity and heterogeneity of the targeted systems, platforms and concerns. In addition, tools capable of conjointly catering for the complete design-verificationdeployment cycle, extra-functional properties and reuse are currently lacking. To address this, we have developed Pride, an integrated development environment for component-based development of embedded systems. Pride is based on an architecture relying on components with well-defined semantics that serve as the central development entity, and as means to support and aggregate various analysis and verification techniques throughout the development - from early specification to synthesis and deployment. Pride also provides generic support for integrating extra-functional properties into architectural definitions.
32.	Borde, E., et al. (författare) Towards verified synthesis of ProCom, a component model for real-time embedded systems 2011 Ingår i: CompArch - Proceedings of the 2011 Federated Events on Component-Based Software Engineering and Software Architecture - CBSE'11. - New York, NY, USA : ACM. - 9781450307239 ; , s. 129-138 Konferensbidrag (refereegranskat)abstract To take advantage of component-based software engineering, software designers need a component framework that automates the assemblage and integration of developed components. It is then of prime importance to ensure that the synthesized code respects the definition of the component model's semantics. This is all the more difficult in the domain of embedded systems since the considered semantics usually aims at characterizing both functional properties (e.g. data and control dependencies) and non-functional properties such as timing and memory consumption. The component model considered in this paper, called ProCom, relies on an asynchronous operational semantics and a formal hypothesis of atomic and instantaneous interactions between components. The asynchronous approach targets higher exibility in the deployment and analysis process, while the formal hypothesis helps in reducing the combinatory problems of formal verification. In this paper, we present a code generation strategy to synthesize ProCom components, and a formalization of this generated code. This formalization extends the verification possibilities of ProCom architectures, and constitutes a step toward the verification that the produced code respects the operational semantics of ProCom. © 2011 ACM.
33.	Bures, Tomas, et al. (författare) A Component Model Family for Vehicular Embedded Systems 2008 Ingår i: The 3rd International Conference on Software Engineering Advances, ICSEA 2008, Includes ENTISY 2008: International Workshop on Enterprise Information Systems. - 9780769533728 ; , s. 437-444 Konferensbidrag (refereegranskat)abstract In this paper we propose to use components for managingthe increasing complexity in modern vehicular systems.Compared to other approaches, the distinguishingfeature of our work is using and benefiting from componentsthroughout the development process from early designto development and deployment, and an explicit separationof concerns at different levels of granularity. Basedon the elaboration of the specifics of vehicular systems (resourceconstraints, real-time requirements, hard demandson reliability), the paper identifies concerns that need to beaddressed by a component model for this domain, and describesa realization of such a component model.
34.	Bures, Tomas, et al. (författare) ProCom - the Progress Component Model Reference Manual, version 1.0 2008 Rapport (övrigt vetenskapligt/konstnärligt)
35.	Bures, Tomas, et al. (författare) Progress Component Model Reference Manual - version 0.5 2008 Rapport (övrigt vetenskapligt/konstnärligt)abstract This report describes the component model developed within PROGRESS. In addition to defining the syntax and semantics, it also gives some background and motivation, and describes how this work relates to the overall PROGRESS vision and to the work in other areas of the project.
36.	Bures, Tomas, et al. (författare) Towards Component Modelling of Embedded Systems in the Vehicular Domain 2008 Rapport (övrigt vetenskapligt/konstnärligt)abstract The complexity of software and electronics in vehicular systems has increased significantly over last few years - up to the point when it is difficult to manage it with existing development methods. In this paper we aim at using components for managing the complexity in vehicular systems. Compared to other approaches, the distinguishing feature of our work is using and benefiting from components throughout the whole development process (from early design to development and deployment). Based on the elaboration of the specifics of vehicular systems (resource constraints, real-time requirements, hard demands on reliability), the paper identifies concerns that need to be addressed by a component model for this domain. It also outlines basic features and characteristics of such a component model and discusses how relevant existing formalisms and component models relate to it and how they could be reused within the proposed approach.
37.	Burt, Richard K., et al. (författare) Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis : A Randomized Clinical Trial 2019 Ingår i: Journal of the American Medical Association (JAMA). - : AMER MEDICAL ASSOC. - 0098-7484 .- 1538-3598. ; 321:2, s. 165-174 Tidskriftsartikel (refereegranskat)abstract IMPORTANCE Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS).OBJECTIVE To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression.DESIGN, SETTING, AND PARTICIPANTS Between September 20, 2005, and July 7, 2016, a total of 110 patients with relapsing-remitting MS, at least 2 relapses while receiving DMT in the prior year, and an Expanded Disability Status Scale (EDSS; score range, 0-10 [10 = worst neurologic disability]) score of 2.0 to 6.0 were randomized at 4 US, European, and South American centers. Final follow-up occurred in January 2018 and database lock in February 2018.INTERVENTIONS Patients were randomized to receive HSCT along with cyclophosphamide (200mg/kg) and antithymocyte globulin (6mg/kg) (n = 55) or DMT of higher efficacy or a different class than DMT taken during the previous year (n = 55).MAIN OUTCOMES AND MEASURES The primary end point was disease progression, defined as an EDSS score increase after at least 1 year of 1.0 point or more (minimal clinically important difference, 0.5) on 2 evaluations 6 months apart, with differences in time to progression estimated as hazard ratios. RESULTS Among 110 randomized patients (73 [66%] women; mean age, 36 [SD, 8.6] years), 103 remained in the trial, with 98 evaluated at 1 year and 23 evaluated yearly for 5 years (median follow-up, 2 years; mean, 2.8 years). Disease progression occurred in 3 patients in the HSCT group and 34 patients in the DMT group. Median time to progression could not be calculated in the HSCT group because of too few events; it was 24 months (interquartile range, 18-48 months) in the DMT group (hazard ratio, 0.07; 95% CI, 0.02-0.24; P < .001). During the first year, mean EDSS scores decreased (improved) from 3.38 to 2.36 in the HSCT group and increased (worsened) from 3.31 to 3.98 in the DMT group (between-group mean difference,-1.7; 95% CI,-2.03 to -1.29; P < .001). There were no deaths and no patients who received HSCT developed nonhematopoietic grade 4 toxicities (such as myocardial infarction, sepsis, or other disabling or potential life-threatening events).CONCLUSIONS AND RELEVANCE In this preliminary study of patients with relapsing-remitting MS, nonmyeloablative HSCT, compared with DMT, resulted in prolonged time to disease progression. Further research is needed to replicate these findings and to assess long-term outcomes and safety.
38.	Campeanu, Gabriel, et al. (författare) A GPU-aware Component Model Extension for Heterogeneous Embedded Systems 2015 Ingår i: The Tenth International Conference on Software Engineering Advances ICSEA 2015. - 9781612084381 Konferensbidrag (refereegranskat)abstract One way for modern embedded systems to tackle the demand for more complex functionality requiring more computational power is to take advantage of heterogeneous hardware. These hardware platforms are constructed from the combination of different processing units including both traditional CPUs and for example Graphical Processing Units (GPUs). However, there is a lack of efficient approaches supporting software development for such systems. In particular, modern software development approaches, such as component-based development, do not provide sufficient support for heterogeneous hardware platforms. This paper presents a component model extension, which defines specific features for components with GPU capabilities. The benefits of the proposed solution include an increased system performance by accelerating the communication between GPU-aware components and the possibility to control the distribution of GPU computation resources at system level.
39.	Campeanu, Gabriel, et al. (författare) Allocation Optimization for Component-based Embedded Systems with GPUs 2018 Ingår i: 44th Euromicro Conference on Software Engineering and Advanced Applications SEAA 2018. - 9781538673829 ; , s. 101-110 Konferensbidrag (refereegranskat)abstract Platforms equipped with GPU processors help mitigating the ever-increasing computational demands of modern embedded systems. Such systems can be specifically developed by using component-based development thanks to the concept of flexible components. Through this concept, a component can be transparently executed either on a CPU or a GPU. However, this flexibility complicates the allocation process because it adds additional complexity (i.e., due to the undecided CPU or GPU execution) and constraints to consider (i.e., CPUs and GPUs properties). In this work, we address this problem by providing an optimization model for component-based embedded systems executing on both CPU and GPU. The model addresses important optimization goals, characteristic to the embedded system domain, such as memory usage, energy usage and execution time. A novelty of this work is the formal description of the optimization model, which supports the usage of mixed integer nonlinear programming to compute optimal allocation schemes. To examine the feasibility of the proposed method, we apply the optimization model on a vision system constructed using the industrial Rubus component model.
40.	Campeanu, Gabriel, et al. (författare) Component Allocation Optimization for Heterogeneous CPU-GPU Embedded Systems 2014 Ingår i: The 40th Euromicro Conference on Software Engineering and Advanced Applications SEAA 2014, Verona, 27-29 Aug. 2014. - 9781479957941 ; , s. 229-236 Konferensbidrag (refereegranskat)abstract In a quest to improve system performance, embedded systems are today increasingly relying on heterogeneous platforms that combine different types of processing units such as CPUs, GPUs and FPGAs. However, having better hardware capability alone does not guarantee higher performance; how functionality is allocated onto the appropriate processing units strongly impacts the system performance as well. Yet, with this increase in hardware complexity, finding suitable allocation schemes is becoming a challenge as many new constraints and requirements must now be taken into consideration. In this paper, we present a formal model for allocation optimization of embedded systems which contains a mix of CPU and GPU processing nodes. The allocation takes into consideration the software and hardware architectures, the system requirements and criteria upon which the allocation should be optimized. In its current version, optimized allocation schemes are generated through an integer programming technique to balance the system resource utilization and to optimize the system performance using the GPU resources.
41.	Campeanu, Gabriel, et al. (författare) Component-based development of embedded systems with GPUs 2020 Ingår i: Journal of Systems and Software. - : Elsevier Inc.. - 0164-1212 .- 1873-1228. ; 161 Tidskriftsartikel (refereegranskat)abstract One pressing challenge of many modern embedded systems is to successfully deal with the considerable amount of data that originates from the interaction with the environment. A recent solution comes from the use of GPUs, providing a significantly improved performance for data-parallel applications. Another trend in the embedded systems domain is component-based development. However, existing component-based approaches lack specific support to develop embedded systems with GPUs. As a result, components with GPU capability need to encapsulate all the required GPU information, leading to component specialization to specific platforms, hence drastically impeding component reusability. To facilitate component-based development of embedded systems with GPUs, we introduce the concept of flexible components. This increases the design flexibility by allowing the system developer to decide component allocation (i.e., either the CPU or GPU) at a later stage of the system development, with no change to the component implementation. Furthermore, we provide means to automatically generate code for adapting flexible components corresponding to their hardware placement, as well as code for component communication. Through the introduced support, components with GPU capability are platform-independent, and can be executed, without manual adjustment, on a large variety of hardware (i.e., platforms with different GPU characteristics).
42.	Campeanu, Gabriel, et al. (författare) Developing CPU-GPU Embedded Systems using Platform-Agnostic Components 2017 Ingår i: Proceedings - 43rd Euromicro Conference on Software Engineering and Advanced Applications, SEAA 2017. - 9781538621400 ; , s. 176-180 Konferensbidrag (refereegranskat)abstract Nowadays, there are many embedded systems with different architectures that have incorporated GPUs. However, it is difficult to develop CPU-GPU embedded systems using component-based development (CBD), since existing CBD ap- proaches have no support for GPU development. In this context, when targeting a particular CPU-GPU platform, the component developer is forced to construct hardware-specific components, which are problematic to (re-)use in different contexts. More- over, hard-coding specific GPU-usage characteristics (e.g., the number of utilized GPU threads) inside the component is not possible without making detailed assumptions about the system in which the component is used, which conflicts with separation- of-concerns CBD principle. The paper presents a solution to allow component-based development of platform-agnostic CPU-GPU embedded systems through: i) high-level API, ii) adapters, and iii) code template. The API abstracts the specifics of the different platforms, while the adapters externalize hardware-specific activities outside components. We also raise the decision regarding the GPU- usage specifications, from the component to the system level. Furthermore, to minimize the development effort, we provide a code template that contains ready-made code fragments required for GPU development. As a case study, we examine the feasibility of our solution applied on a component-based vision system of an underwater robot.
43.	Campeanu, Gabriel, et al. (författare) Extending the Rubus Component Model with GPU-Aware Components 2016 Ingår i: Proceedings - 2016 19th International ACM SIGSOFT Symposium on Component-Based Software Engineering, CBSE 2016. - 9781509025695 ; , s. 59-68 Konferensbidrag (refereegranskat)abstract To support the complex functionality expected of modern embedded systems, the trend is to supplement CPUs with Graphical Processing Units (GPUs), thus creating heterogeneous embedded systems. However, taking full advantage of GPUs increases the complexity of the development and requires dedicated support, and no such support exists in the component models currently available. The only solution today is to completely encapsulate all GPU-specific information and operations within the components, which increases the communication overhead and reduces component reusability, thus significantly limiting the applicability of component-based development to heterogeneous embedded systems. In this paper, we propose to extend Rubus, an industrial component model for embedded systems, with dedicated support for GPUs. We introduce new constructs, including GPU ports and automatically generated adapters to facilitate seamless component communication over the heterogeneous processing units, regardless of whether the components use the CPU, GPU, or both. A running example is used for the problem description, the proposed extension, and to evaluate our solution.
44.	Campeanu, Gabriel, et al. (författare) Flexible Components for Development of Embedded Systems with GPUs 2017 Ingår i: 24th Asia-Pacific Software Engineering Conference APSEC 2017. - 9781538636817 ; , s. 219-228 Konferensbidrag (refereegranskat)abstract Today, embedded systems incorporate GPUs through a multitude of different architectures. When it comes to the development of these systems with GPUs, component-based development is ill-equipped as it does not provide support for GPUs. Instead, the component developer needs to encapsulate inside the component, besides functionality, settings and environment information that are specific to a particular GPU architecture. This binds the component this GPU architecture. Using these hardware-specific components characterized by restricted reusability, the system developer is confined to a limited design space which may negatively impact the overall system feasibility. In this paper, we introduce the concept of flexible components, which are components that can be executed indifferently on CPU or GPU, regardless of the architecture. Using flexible components, component developers are relieved from the side development activities (e.g., environment information) which are automatically handled by component-level mechanisms. To enhance component communications, connection elements (i.e., adapters) are generated to handle component data transmission, taking in consideration the platform characteristics. Finally, our proposed solution is evaluated by using flexible components to implement the vision system of an underwater robot, and execute it on three platforms with different GPU architectures.
45.	Campeanu, Gabriel, 1982- (författare) GPU-aware Component-based Development for Embedded Systems 2016 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract Nowadays, more and more embedded systems are equipped with e.g., various sensors that produce large amount of data. One of the challenges of traditional (CPU-based) embedded systems is to process this considerable amount of data such that it produces the appropriate performance level demanded by embedded applications. A solution comes from the usage of a specialized processing unit such as Graphics Processing Unit (GPU). A GPU can process large amount of data thanks to its parallel processing architecture, delivering an im- proved performance outcome compared to CPU. A characteristic of the GPU is that it cannot work alone; the CPU must trigger all its activities. Today, taking advantage of the latest technology breakthrough, we can benefit of the GPU technology in the context of embedded systems by using heterogeneous CPU-GPU embedded systems.Component-based development has demonstrated to be a promising methology in handling software complexity. Through component models, which describe the component specification and their interaction, the methodology has been successfully used in embedded system domain. The existing component models, designed to handle CPU-based embedded systems, face challenges in developing embedded systems with GPU capabilities. For example, current so- lutions realize the communication between components with GPU capabilities via the RAM system. This introduces an undesired overhead that negatively affects the system performance.This Licentiate presents methods and techniques that address the component- based development of embedded systems with GPU capabilities. More concretely, we provide means for component models to explicitly address the GPU-aware component-based development by using specific artifacts. For example, the overhead introduced by the traditional way of communicating via RAM is reduced by inserting automatically generated adapters that facilitate a direct component communication over the GPU memory.Another contribution of the thesis is a component allocation method over the system hardware. The proposed solution offers alternative options in opti- mizing the total system performance and balancing various system properties (e.g., memory usage, GPU load). For the validation part of our proposed solutions, we use an underwater robot demonstrator equipped with GPU hardware.
46.	Campeanu, Gabriel, 1982- (författare) GPU Support for Component-based Development of Embedded Systems 2018 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract One pressing challenge of many modern embedded systems is to successfully deal with the considerable amount of data that originates from the interaction with the environment. A recent solution comes from the use of GPUs. Equipped with a parallel execution model, the GPU excels in parallel processing applications, providing an improved performance compared to the CPU.Another trend in the embedded systems domain is the use of component-based development. This software engineering paradigm that promotes construction of applications through the composition of software components, has been successfully used in the development of embedded systems. However, the existing approaches provide no specific support to develop embedded systems with GPUs. As a result, components with GPU capability need to encapsulate all the required GPU information in order to be successfully executed by the GPU. This leads to component specialization to specific platforms, hence drastically impeding component reusability.Our main goal is to facilitate component-based development of embedded systems with GPUs. We introduce the concept of flexible component which increases the flexibility to design embedded systems with GPUs, by allowing the system developer to decided where to place the component, i.e., either on the CPU or GPU. Furthermore, we provide means to automatically generate the required information for flexible components corresponding to their hardware placement, and to improve component communication. Through the introduced support, components with GPU capability are platform-independent, being capable to be executed on a large variety of hardware (i.e., platforms with different GPU characteristics). Furthermore, an optimization step is introduced, which groups connected flexible components into single entities that behave as regular components. Dealing with components that can be executed either by the CPU or GPU, we also introduce an allocation optimization method. The proposed solution, implemented using a mathematical solver, offers alternative options in optimizing particular system goals (e.g., memory and energy usage).
47.	Campeanu, Gabriel, et al. (författare) Optimized Realization of Software Components with Flexible OpenCL Functionality 2018 Ingår i: Proceedings of the 13th International Conference on Evaluation of Novel Approaches to Software Engineering, ENASE 2018, Funchal, Madeira, Portugal, March 23-24, 2018. - : SCITEPRESS - Science and Technology Publications. - 9789897583001 ; , s. 77-88 Konferensbidrag (refereegranskat)abstract Today, the newly available embedded boards with GPUs provide a solution to satisfy the ever-increasing requirements of modern embedded systems. Component-based development is a well-known paradigm used to develop embedded systems. However, this paradigm lacks GPU support to address the specifics of these new boards. This leads to components that typically have reduced reusability, poor maintainability and portability. One way to tackle the existing shortcomings is through flexible components, i.e., platform-agnostic components that, at design time, offer the possibility to be executed either on CPU or GPU. The current realization of flexible components, i.e., as regular components with functionality tailored for the selected hardware, introduces additional overheads such as component communication overhead. In order to tackle the introduced overheads, our solution groups connected flexible components under a flexible group that conceptually behaves as a component. We introduce an algorithm to identify the existing groups in a given component-based system and the generation rules that automatically realizes groups as regular components. To evaluate the feasibility of the new concept, the flexible group is implemented using a state-of-the-practice component model (i.e., Rubus) and examined through the vision system of an underwater robot.
48.	Capannini, Gabriele, et al. (författare) Reliable Visibility Algorithms for Emergency Stop Systems in Smart Industries 2022 Ingår i: Proceedings - 2022 IEEE 46th Annual Computers, Software, and Applications Conference, COMPSAC 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665488105 ; , s. 89-94 Konferensbidrag (refereegranskat)abstract Automated machinery and robots working with humans are the norm in modern smart industries. A previous work in this area proposed a tool for improving the safety of such work places: an emergency system which halts those machines that are visible from an emergency stop button when it is pressed [1]. The solution presented in this paper improves the reliability of the aforementioned one at the expense of a higher computational complexity. Furthermore, two algorithmic optimizations are presented to mitigate the extra computational cost as it is shown by the results collected from the set of experiments conducted.
49.	Capannini, Gabriele, et al. (författare) Thou Shalt Not Move : A Visibility-based Emergency Stop System for Smart Industries 2021 Ingår i: ACM International Conference Proceeding Series. - New York, NY, USA : Association for Computing Machinery. - 9781450390576 Konferensbidrag (refereegranskat)abstract Nowadays, industries are crowded with automatized machinery and robots that interact with human operators. In addition to other safety measures already present, we propose a further tool to equip such working places with a visibility-based emergency stop system that only affects those machines that are visible from the position of an emergency stop button when it is pressed. This paper presents the realization of such a system and the preliminary results collected from the conducted scalability experiments.
50.	Carlson, Elwood, et al. (författare) Low-weight Neonatal Survival Paradox in the Czech Republic 1999 Ingår i: American Journal of Epidemiology. - 0002-9262 .- 1476-6256. ; 149:5, s. 447-453 Tidskriftsartikel (refereegranskat)abstract Analysis of vital statistics for the Czech Republic between 1986 and 1993, including 3,254 infant deaths from350,978 first births to married and single women who conceived at ages 18-29 years, revealed a neonatalsurvival advantage for low-weight infants born to disadvantaged (single, less educated) women, particularly fordeaths from congenital anomalies. This advantage largely disappeared after the neonatal period. The samepatterns have been observed for low-weight infants born to black women in the United States. Since the CzechRepublic had an ethnically homogenous population, virtually universal prenatal care, and uniform institutionalconditions for delivery, Czech results must be attributed to social rather than to biologic or medicalcircumstances. This strengthens the contention that in the United States, the black neonatal survival paradoxmay be due as much to race-related social stigmatization and consequent disadvantage as to any hypothesizedhereditary influences on birth-weight-specific survival. Am J Epidemiol 1999; 149:447-53.

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