| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 11. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 12. |
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| 13. |
- Bouyoucef, S E, et al.
(författare)
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Poster Session 2 : Monday 4 May 2015, 08
- 2015
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Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 14. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 15. |
- Abdellaoui, G., et al.
(författare)
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Meteor studies in the framework of the JEM-EUSO program
- 2017
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Ingår i: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 143, s. 245-255
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Tidskriftsartikel (refereegranskat)abstract
- We summarize the state of the art of a program of UV observations from space of meteor phenomena, a secondary objective of the JEM-EUSO international collaboration. Our preliminary analysis indicates that JEM-EUSO, taking advantage of its large FOV and good sensitivity, should be able to detect meteors down to absolute magnitude close to 7. This means that JEM-EUSO should be able to record a statistically significant flux of meteors, including both sporadic ones, and events produced by different meteor streams. Being unaffected by adverse weather conditions, JEM-EUSO can also be a very important facility for the detection of bright meteors and fireballs, as these events can be detected even in conditions of very high sky background. In the case of bright events, moreover, exhibiting some persistence of the meteor train, preliminary simulations show that it should be possible to exploit the motion of the ISS itself and derive at least a rough 3D reconstruction of the meteor trajectory. Moreover, the observing strategy developed to detect meteors may also be applied to the detection of nuclearites, exotic particles whose existence has been suggested by some theoretical investigations. Nuclearites are expected to move at higher velocities than meteoroids, and to exhibit a wider range of possible trajectories, including particles moving upward after crossing the Earth. Some pilot studies, including the approved Mini-EUSO mission, a precursor of JEM-EUSO, are currently operational or in preparation. We are doing simulations to assess the performance of Mini-EUSO for meteor studies, while a few meteor events have been already detected using the ground-based facility EUSO-TA.
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| 16. |
- Atwood, W. B., et al.
(författare)
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THE LARGE AREA TELESCOPE ON THE FERMI GAMMA-RAY SPACE TELESCOPE MISSION
- 2009
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 697:2, s. 1071-1102
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Tidskriftsartikel (refereegranskat)abstract
- The Large Area Telescope (Fermi/LAT, hereafter LAT), the primary instrument on the Fermi Gamma-ray Space Telescope (Fermi) mission, is an imaging, wide field-of-view (FoV), high-energy gamma-ray telescope, covering the energy range from below 20 MeV to more than 300 GeV. The LAT was built by an international collaboration with contributions from space agencies, high-energy particle physics institutes, and universities in France, Italy, Japan, Sweden, and the United States. This paper describes the LAT, its preflight expected performance, and summarizes the key science objectives that will be addressed. On-orbit performance will be presented in detail in a subsequent paper. The LAT is a pair-conversion telescope with a precision tracker and calorimeter, each consisting of a 4 x 4 array of 16 modules, a segmented anticoincidence detector that covers the tracker array, and a programmable trigger and data acquisition system. Each tracker module has a vertical stack of 18 (x, y) tracking planes, including two layers (x and y) of single-sided silicon strip detectors and high-Z converter material (tungsten) per tray. Every calorimeter module has 96 CsI(Tl) crystals, arranged in an eight-layer hodoscopic configuration with a total depth of 8.6 radiation lengths, giving both longitudinal and transverse information about the energy deposition pattern. The calorimeter's depth and segmentation enable the high-energy reach of the LAT and contribute significantly to background rejection. The aspect ratio of the tracker (height/width) is 0.4, allowing a large FoV (2.4 sr) and ensuring that most pair-conversion showers initiated in the tracker will pass into the calorimeter for energy measurement. Data obtained with the LAT are intended to (1) permit rapid notification of high-energy gamma-ray bursts and transients and facilitate monitoring of variable sources, (2) yield an extensive catalog of several thousand high-energy sources obtained from an all-sky survey, (3) measure spectra from 20 MeV to more than 50 GeV for several hundred sources, (4) localize point sources to 0.3-2 arcmin, (5) map and obtain spectra of extended sources such as SNRs, molecular clouds, and nearby galaxies, (6) measure the diffuse isotropic gamma-ray background up to TeV energies, and (7) explore the discovery space for dark matter.
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| 17. |
- De Angelis, A., et al.
(författare)
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Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics
- 2018
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Ingår i: Journal of High Energy Astrophysics. - : Elsevier. - 2214-4048 .- 2214-4056. ; 19, s. 1-106
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Tidskriftsartikel (refereegranskat)abstract
- e-ASTROGAM ('enhanced ASTROGAM') is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV - the lower energy limit can be pushed to energies as low as 150 keV for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and LISA.
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| 18. |
- Abdellaoui, G., et al.
(författare)
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First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
- 2018
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Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25(th) of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector.
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| 19. |
- Abdo, A. A., et al.
(författare)
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The on-orbit calibration of the Fermi Large Area Telescope
- 2009
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 32:3-4, s. 193-219
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Tidskriftsartikel (refereegranskat)abstract
- The Large Area Telescope (LAT) on-board the Fermi Gamma-ray Space Telescope began its on-orbit operations on June 23, 2008. Calibrations, defined in a generic sense, correspond to synchronization of trigger signals, optimization of delays for latching data, determination of detector thresholds, gains and responses, evaluation of the perimeter of the South Atlantic Anomaly (SAA), measurements of live time, of absolute time, and internal and spacecraft boresight alignments. Here we describe on-orbit calibration results obtained using known astrophysical sources, galactic cosmic rays, and charge injection into the front-end electronics of each detector. Instrument response functions will be described in a separate publication. This paper demonstrates the stability of calibrations and describes minor changes observed since launch. These results have been used to calibrate the LAT datasets to be publicly released in August 2009.
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| 20. |
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| 21. |
- Abdo, A. A., et al.
(författare)
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A Population of Gamma-Ray Millisecond Pulsars Seen with the Fermi Large Area Telescope
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 325:5942, s. 848-852
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Tidskriftsartikel (refereegranskat)abstract
- Pulsars are born with subsecond spin periods and slow by electromagnetic braking for several tens of millions of years, when detectable radiation ceases. A second life can occur for neutron stars in binary systems. They can acquire mass and angular momentum from their companions, to be spun up to millisecond periods and begin radiating again. We searched Fermi Large Area Telescope data for pulsations from all known millisecond pulsars (MSPs) outside of globular clusters, using rotation parameters from radio telescopes. Strong gamma-ray pulsations were detected for eight MSPs. The gamma-ray pulse profiles and spectral properties resemble those of young gamma-ray pulsars. The basic emission mechanism seems to be the same for MSPs and young pulsars, with the emission originating in regions far from the neutron star surface.
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| 22. |
- Abdo, A. A., et al.
(författare)
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The Fermi Gamma-Ray Space Telescope Discovers the Pulsar in the Young Galactic Supernova Remnant CTA 1
- 2008
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 322:5905, s. 1218-1221
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Tidskriftsartikel (refereegranskat)abstract
- Energetic young pulsars and expanding blast waves [ supernova remnants (SNRs)] are the most visible remains after massive stars, ending their lives, explode in core-collapse supernovae. The Fermi Gamma- Ray Space Telescope has unveiled a radio quiet pulsar located near the center of the compact synchrotron nebula inside the supernova remnant CTA 1. The pulsar, discovered through its gamma- ray pulsations, has a period of 316.86 milliseconds and a period derivative of 3.614 x 10(-13) seconds per second. Its characteristic age of 10(4) years is comparable to that estimated for the SNR. We speculate that most unidentified Galactic gamma- ray sources associated with star- forming regions and SNRs are such young pulsars.
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| 23. |
- Abdo, A. A., et al.
(författare)
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Fermi LAT Observation of Diffuse Gamma Rays Produced Through Interactions Between Local Interstellar Matter and High-energy Cosmic Rays
- 2009
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Ingår i: Astrophysical Journal Supplement Series. - 0067-0049 .- 1538-4365. ; 703:2, s. 1249-1256
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Tidskriftsartikel (refereegranskat)abstract
- Observations by the Large Area Telescope (LAT) on the Fermi mission of diffuse γ-rays in a mid-latitude region in the third quadrant (Galactic longitude l from 200° to 260° and latitude |b| from 22° to 60°) are reported. The region contains no known large molecular cloud and most of the atomic hydrogen is within 1 kpc of the solar system. The contributions of γ-ray point sources and inverse Compton scattering are estimated and subtracted. The residual γ-ray intensity exhibits a linear correlation with the atomic gas column density in energy from 100 MeV to 10 GeV. The measured integrated γ-ray emissivity is (1.63 ± 0.05) × 10-26 photons s-1sr-1 H-atom-1 and (0.66 ± 0.02) × 10-26 photons s-1sr-1 H-atom-1 above 100 MeV and above 300 MeV, respectively, with an additional systematic error of ~10%. The differential emissivity from 100 MeV to 10 GeV agrees with calculations based on cosmic ray spectra consistent with those directly measured, at the 10% level. The results obtained indicate that cosmic ray nuclei spectra within 1 kpc from the solar system in regions studied are close to the local interstellar spectra inferred from direct measurements at the Earth within ~10%.
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| 24. |
- Abdo, A. A., et al.
(författare)
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Measurement of the Cosmic Ray e(+)+e(-) Spectrum from 20 GeV to 1 TeV with the Fermi Large Area Telescope
- 2009
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:Article number: 181101
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Tidskriftsartikel (refereegranskat)abstract
- Designed as a high-sensitivity gamma-ray observatory, the Fermi Large Area Telescope is also an electron detector with a large acceptance exceeding 2 m(2) sr at 300 GeV. Building on the gamma-ray analysis, we have developed an efficient electron detection strategy which provides sufficient background rejection for measurement of the steeply falling electron spectrum up to 1 TeV. Our high precision data show that the electron spectrum falls with energy as E-3.0 and does not exhibit prominent spectral features. Interpretations in terms of a conventional diffusive model as well as a potential local extra component are briefly discussed.
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| 25. |
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| 26. |
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| 27. |
- Ackermann, M., et al.
(författare)
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Fermi LAT observations of cosmic-ray electrons from 7 GeV to 1 TeV
- 2010
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Ingår i: PHYSICAL REVIEW D. - 1550-7998. ; 82:9, s. 092004-
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of our analysis of cosmic-ray electrons using about 8 x 10(6) electron candidates detected in the first 12 months on-orbit by the Fermi Large Area Telescope. This work extends our previously published cosmic-ray electron spectrum down to 7 GeV, giving a spectral range of approximately 2.5 decades up to 1 TeV. We describe in detail the analysis and its validation using beam-test and on-orbit data. In addition, we describe the spectrum measured via a subset of events selected for the best energy resolution as a cross-check on the measurement using the full event sample. Our electron spectrum can be described with a power law proportional to E-3.08+/-0.05 with no prominent spectral features within systematic uncertainties. Within the limits of our uncertainties, we can accommodate a slight spectral hardening at around 100 GeV and a slight softening above 500 GeV.
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| 28. |
- Wang, Li-San, et al.
(författare)
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Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- 2015
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
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| 29. |
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| 30. |
- Adriani, O., et al.
(författare)
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Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
- 2013
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Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
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Tidskriftsartikel (refereegranskat)abstract
- It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
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| 31. |
- Bazilevskaya, G. A., et al.
(författare)
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Solar proton events at the end of the 23rd and start of the 24th solar cycle recorded in the PAMELA experiment
- 2013
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 493-496
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA magnetic spectrometer was launched into a near-Earth orbit on board the Resurs-DK1 satellite in June 2006; in December 2006, it recorded the last strong solar high-energy particle event of the 23rd solar cycle. A deficit was thereafter observed in solar energetic particle events because of the lengthy solar activity minimum and the weak evolution of the next (24th) solar cycle. As a result, only a few solar events involving protons with energies of more than 100 MeV were recorded between 2010 and 1012. This work presents the preliminary results from measurements of charged particle fluxes in these events, recorded by the Pamela spectrometer.
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| 32. |
- Dalton, A. S., et al.
(författare)
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An updated radiocarbon-based ice margin chronology for the last deglaciation of the North American Ice Sheet Complex
- 2020
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791. ; 234
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Tidskriftsartikel (refereegranskat)abstract
- The North American Ice Sheet Complex (NAISC; consisting of the Laurentide, Cordilleran and Innuitian ice sheets) was the largest ice mass to repeatedly grow and decay in the Northern Hemisphere during the Quaternary. Understanding its pattern of retreat following the Last Glacial Maximum is critical for studying many facets of the Late Quaternary, including ice sheet behaviour, the evolution of Holocene landscapes, sea level, atmospheric circulation, and the peopling of the Americas. Currently, the most up-to-date and authoritative margin chronology for the entire ice sheet complex is featured in two publications (Geological Survey of Canada Open File 1574 [Dyke et al., 2003]; 'Quaternary Glaciations - Extent and Chronology, Part II' [Dyke, 2004]). These often-cited datasets track ice margin recession in 36 time slices spanning 18 ka to 1 ka (all ages in uncalibrated radiocarbon years) using a combination of geomorphology, stratigraphy and radiocarbon dating. However, by virtue of being over 15 years old, the ice margin chronology requires updating to reflect new work and important revisions. This paper updates the aforementioned 36 ice margin maps to reflect new data from regional studies. We also update the original radiocarbon dataset from the 2003/2004 papers with 1541 new ages to reflect work up to and including 2018. A major revision is made to the 18 ka ice margin, where Banks and Eglinton islands (once considered to be glacial refugia) are now shown to be fully glaciated. Our updated 18 ka ice sheet increased in areal extent from 17.81 to 18.37 million km(2), which is an increase of 3.1% in spatial coverage of the NAISC at that time. Elsewhere, we also summarize, region-by-region, significant changes to the deglaciation sequence. This paper integrates new information provided by regional experts and radiocarbon data into the deglaciation sequence while maintaining consistency with the original ice margin positions of Dyke et al. (2003) and Dyke (2004) where new information is lacking; this is a pragmatic solution to satisfy the needs of a Quaternary research community that requires up-to-date knowledge of the pattern of ice margin recession of what was once the world's largest ice mass. The 36 updated isochrones are available in PDF and shapefile format, together with a spreadsheet of the expanded radiocarbon dataset (n = 5195 ages) and estimates of uncertainty for each interval. (C) 2020 Elsevier Ltd. All rights reserved.
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| 33. |
- Mayorov, A. G., et al.
(författare)
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Antiprotons of galactic cosmic radiation in the PAMELA experiment
- 2013
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 602-605
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Tidskriftsartikel (refereegranskat)abstract
- A method for antiproton selection against a background of electrons, based on a mathematical model of data classification using variations in interparticle interaction in a calorimeter, and a method for excluding events accompanied by scattering in the inner detectors of a tracking system (which result in errors in the measured trajectory's curvature and charge sign) from analysis are discussed in this paper. Antiproton spectra and antiproton/proton flux ratio at energies of 0.06 to 350 GeV with statistics of events surpassing those in [1] are obtained. The results can be used to create models for the generation and distribution of particles in the Galaxy, and for searching and studying the nature of hypothetical dark matter particles.
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| 34. |
- Adriani, O., et al.
(författare)
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Measurements of quasi-trapped electron and positron fluxes with PAMELA
- 2009
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114, s. A12218-
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents precise measurements of the differential energy spectra of quasi-trapped secondary electrons and positrons and their ratio between 80 MeV and 10 GeV in the near-equatorial region (altitudes between 350 km and 600 km). Latitudinal dependences of the spectra are analyzed in detail. The results were obtained from July until November 2006 onboard the Resurs-DK satellite by the PAMELA spectrometer, a general purpose cosmic ray detector system built around a permanent magnet spectrometer and a silicon-tungsten calorimeter.
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| 35. |
- Datry, T., et al.
(författare)
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A global analysis of terrestrial plant litter dynamics in non-perennial waterways
- 2018
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Ingår i: Nature Geoscience. - : Nature Publishing Group. - 1752-0894 .- 1752-0908. ; 11:7, s. 497-503
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Tidskriftsartikel (refereegranskat)abstract
- Perennial rivers and streams make a disproportionate contribution to global carbon (C) cycling. However, the contribution of intermittent rivers and ephemeral streams (IRES), which sometimes cease to flow and can dry completely, is largely ignored although they represent over half the global river network. Substantial amounts of terrestrial plant litter (TPL) accumulate in dry riverbeds and, upon rewetting, this material can undergo rapid microbial processing. We present the results of a global research collaboration that collected and analysed TPL from 212 dry riverbeds across major environmental gradients and climate zones. We assessed litter decomposability by quantifying the litter carbon-to-nitrogen ratio and oxygen (O2) consumption in standardized assays and estimated the potential short-term CO2 emissions during rewetting events. Aridity, cover of riparian vegetation, channel width and dry-phase duration explained most variability in the quantity and decomposability of plant litter in IRES. Our estimates indicate that a single pulse of CO2 emission upon litter rewetting contributes up to 10% of the daily CO2 emission from perennial rivers and stream, particularly in temperate climates. This indicates that the contributions of IRES should be included in global C-cycling assessments.
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| 36. |
- Koldobskiy, S. A., et al.
(författare)
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Deuteron spectrum measurements under radiation belt with PAMELA instrument
- 2016
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Ingår i: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 2345-2347
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Tidskriftsartikel (refereegranskat)abstract
- In this work the results of data analysis of the deuteron albedo radiation obtained in the PAMELA experiment are presented. PAMELA is an international space experiment carried out on board of the satellite Resurs DK-1. The high precision detectors allow to register and identify cosmic ray particles in a wide energy range. The albedo deuteron spectrum in the energy range 70 - 600 MeV/nucleon has been measured.
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| 37. |
- Koldobskiy, S. A., et al.
(författare)
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Measurement of galactic cosmic-ray deuteron spectrum in the PAMELA experiment
- 2013
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press. - 1062-8738. ; 77:5, s. 606-608
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Tidskriftsartikel (refereegranskat)abstract
- This work presents the results of measuring the deuteron spectrum of Galactic cosmic rays (GCRs) with the PAMELA experiment. The PAMELA is an international experiment. Its main objectives are to search for antimatter and measure proton, helium nuclei, electron, and positron spectra over a wide range of energies. In addition, the experimental setup allows the detection of deuterons and the reconstruction of their spectra at low energies. Cosmic ray deuteron spectrum and the deuteron-proton ratio measured in the PAMELA experiment in the energy range of 50-650 MeV/nucleon are presented below.
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| 38. |
- Mayorov, A. G., et al.
(författare)
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Solar modulation of galactic cosmic rays during 2006-2015 based on PAMELA and ARINA data
- 2017
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Ingår i: International Conference On Particle Physics And Astrophysics. - : Institute of Physics Publishing (IOPP).
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Konferensbidrag (refereegranskat)abstract
- Solar modulation of galactic protons with energies from 50 MeV up to dozens of GeV during July '06 - January '16 studied based on a data of the magnetic spectrometer PAMELA and scintillation spectrometer ARINA. This period is interesting because it covers the end of 23(rd) and current 24(th) cycles of solar activity, including the abnormally long transient period and change of the polarity of solar magnetic field.
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| 39. |
- von Schiller, D., et al.
(författare)
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Sediment Respiration Pulses in Intermittent Rivers and Ephemeral Streams
- 2019
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Ingår i: Global Biogeochemical Cycles. - : American Geophysical Union (AGU). - 0886-6236 .- 1944-9224. ; 33:10, s. 1251-1263
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Tidskriftsartikel (refereegranskat)abstract
- Intermittent rivers and ephemeral streams (IRES) may represent over half the global stream network, but their contribution to respiration and carbon dioxide (CO2) emissions is largely undetermined. In particular, little is known about the variability and drivers of respiration in IRES sediments upon rewetting, which could result in large pulses of CO2. We present a global study examining sediments from 200 dry IRES reaches spanning multiple biomes. Results from standardized assays show that mean respiration increased 32-fold to 66-fold upon sediment rewetting. Structural equation modeling indicates that this response was driven by sediment texture and organic matter quantity and quality, which, in turn, were influenced by climate, land use, and riparian plant cover. Our estimates suggest that respiration pulses resulting from rewetting of IRES sediments could contribute significantly to annual CO2 emissions from the global stream network, with a single respiration pulse potentially increasing emission by 0.2-0.7%. As the spatial and temporal extent of IRES increases globally, our results highlight the importance of recognizing the influence of wetting-drying cycles on respiration and CO2 emissions in stream networks.
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| 40. |
- Adriani, O., et al.
(författare)
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Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
- 2013
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Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
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Tidskriftsartikel (refereegranskat)abstract
- We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
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| 41. |
- Bogomolov, E. A., et al.
(författare)
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Spectra of solar neutrons with energies of ~10–1000 MeV in the PAMELA experiment in the flare events of 2006–2015
- 2017
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press Incorporation. - 1062-8738. ; 81:2, s. 132-135
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Tidskriftsartikel (refereegranskat)abstract
- The first results from measuring the spectra of solar neutrons with energies of ~10–1000 MeV in the solar flares of 2006–2015 observed by the PAMELA international space experiment are presented. The PAMELA neutron detector with 3He counters and a moderator with an area of 0.18 m2 allows us to estimate the flux of solar neutrons during solar flares. Solar neutrons with energies of ~10–1000 MeV likely occurred in 21 out of the 24 analyzed flares of 2006–2015.
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| 42. |
- De Simone, N., et al.
(författare)
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Latitudinal and radial gradients of galactic cosmic ray protons in the inner heliosphere - PAMELA and Ulysses observations
- 2011
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Ingår i: Astrophysics and Space Sciences Transactions (ASTRA). - : Copernicus GmbH. - 1810-6528 .- 1810-6536. ; 7:3, s. 425-434
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Tidskriftsartikel (refereegranskat)abstract
- Ulysses, launched on 6 October 1990, was placed in an elliptical, high inclined (80.2°) orbit around the Sun, and was switched off in June 2009. It has been the only spacecraft exploring high-latitude regions of the inner heliosphere. The Kiel Electron Telescope (KET) aboard Ulysses measures electrons from 3 MeV to a few GeV and protons and helium in the energy range from 6 MeV/nucleon to above 2 GeV/nucleon. The PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) space borne experiment was launched on 15 June 2006 and is continuously collecting data since then. The apparatus measures electrons, positrons, protons, anti-protons and heavier nuclei from about 100 MeV to several hundreds of GeV. Thus the combination of Ulysses and PAMELA measurements is ideally suited to determine the spatial gradients during the extended minimum of solar cycle 23. For protons in the rigidity interval 1.6-1.8 GV we find a radial gradient of 2.7%/AU and a latitudinal gradient of -0.024%/degree. Although the latitudinal gradient is as expected negative, its value is much smaller than predicted by current particle propagation models. This result is of relevance for the study of propagation parameters in the inner heliosphere.
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| 43. |
- Huyghe, Jeroen R., et al.
(författare)
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Discovery of common and rare genetic risk variants for colorectal cancer
- 2019
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:1, s. 76-
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Tidskriftsartikel (refereegranskat)abstract
- To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 x 10(-8), bringing the number of known independent signals for CRC to similar to 100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.
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| 44. |
- Karelin, A. V., et al.
(författare)
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North-south asymmetry for high-energy cosmic-ray electrons measured with the PAMELA experiment
- 2013
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Ingår i: Journal of Experimental and Theoretical Physics. - 1063-7761 .- 1090-6509. ; 117:2, s. 268-273
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Tidskriftsartikel (refereegranskat)abstract
- The north-south asymmetry for cosmic-ray particles was measured with one instrument of the PAMELA satellite-borne experiment in the period June 2006-May 2009. The analysis has been performed by two independent methods: by comparing the count rates in regions with identical geomagnetic conditions and by comparing the experimental distribution of particle directions with the simulated distribution that would be in the case of an isotropic particle flux. The dependences of the asymmetry on energy release in the PAMELA calorimeter and on time have been constructed. The asymmetry (N (n) - N (s) )/(N (n) + N (s) ) is 0.06 +/- 0.004 at the threshold energy release in the calorimeter and gradually decreases with increasing energy release. The observed effect is shown to be produced by electrons in the energy range 10-100 GeV.
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| 45. |
- Koldobskiy, S. A., et al.
(författare)
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Galactic deuteron spectrum measured in PAMELA experiment
- 2013
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Ingår i: 23Rd European Cosmic Ray Symposium (And 32Nd Russian Cosmic Ray Conference). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- Results of galactic deuteron spectrum measurement by means of PAMELA apparatus are described. PAMELA is an international experiment developed for antimatter search and measurement of p, He, electron and positron spectra in wide energy range. In addition, PAMELA allows to identify and measure deuteron spectrum at low energies. In this paper deuteron-to-proton ratio and deuteron spectrum are presented.
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| 46. |
- Koldobskiy, S. A., et al.
(författare)
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Solar modulation of cosmic deuteron fluxes in the PAMELA experiment
- 2017
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press Incorporation. - 1062-8738. ; 81:2, s. 151-153
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Tidskriftsartikel (refereegranskat)abstract
- The preliminary results from measurements of deuteron fluxes in galactic cosmic rays (GCR) in the vicinity of the Earth in 2006–2009 are presented. The results are obtained by analyzing data from the PAMELA experiment aboard the Resurs DK-1 satellite. High-precision detection instruments provided an opportunity to identify GCR deuterons and measure their spectrum in the energy interval of 90–650MeV/nucleon. Spectra averaged over six-month intervals from the summer of 2006 to the summer of 2009 (the solar activity minimum) are presented. The influence of solar modulation on the observed spectrum is clearly seen in the results.
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| 47. |
- Koldobskiy, S. A., et al.
(författare)
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Study of deuteron spectra under radiation belt with PAMELA instrument
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- This paper presents the results of measurements of proton and deuteron fluxes of albedo radiation in the Earth vicinity, obtained in the PAMELA experiment. PAMELA is an international experiment meant to study cosmic rays. PAMELA is carried out on board the satellite Resurs-DK1. High-precision equipment of the experiment allows registration and identification of cosmic ray particles of different varieties in a wide energy range. The albedo deuteron spectrum and albedo deuteron-to-proton fluxes ratio in the energy range 70 - 600 MeV/nucleon at altitude of 350 - 600 km for different geomagnetic latitudes is presented.
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| 48. |
- Malakhov, V. V., et al.
(författare)
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Time variations of proton flux in Earth inner radiation belt during 23/24 solar cycles based on the PAMELA and the ARINA data.
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- The PAMELA and the ARINA experiments are carried out on the board of satellite RESURS-DK1 since 2006 up to now. Main goal of the PAMELA instrument is measurements of high energy antiparticles in cosmic rays while the ARINA instrument is intended studying high energy charged particle bursts in the magnetosphere. Both of these experiments have a possibility to study trapped particles in the inner radiation belt. Complex of these two instruments covers proton energy range from 30 MeV up to trapping limit (E= similar to 2 GeV). Continuous measurements with the PAMELA and the ARINA spectrometers include falling and rising phases of 23/24 solar cycles and maximum of 24th one. In this report we present temporal profiles of proton flux in the inner zone of the radiation belt (1.11 < L < 1.18, 0.18 < B < 0.22G). Dependence of proton fluxes on a magnitude of the solar activity was studied for various phases of 23/24 solar cycles. At that it was shown that proton fluxes at the solar minimum are several times greater than at the solar maximum.
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| 49. |
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| 50. |
- Mikhailov, V V, et al.
(författare)
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Cosmic ray electron and positron spectrum with the PAMELA experiment
- 2019
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Ingår i: 36th International Cosmic Ray Conference, ICRC 2019. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- The PAMELA magnetic spectrometer, located on board the Resurs-DK1 satellite on Earth polar orbit with altitude of 350-600 km, measured the fluxes of cosmic ray particles and antiparticles in a wide energy range from 50 MeV to several TeVs. In this paper new results on the "all-electron" (sum electrons and positrons) spectrum are presented. New improved analysis on the full data set from 2006 to 2016 allows a significant increase in statistic compared to previously published results and an extension of energy interval up to 1 TeV.
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