| 1. |
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| 2. |
- Svanberg, Sune, et al.
(författare)
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Applications of terawatt lasers
- 1994
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Ingår i: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
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Konferensbidrag (refereegranskat)
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| 3. |
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| 4. |
- Al-Ramadan, Afkar, et al.
(författare)
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Analysis of radiation effects in two irradiated tumor spheroid models
- 2018
-
Ingår i: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 15:3, s. 3008-3016
-
Tidskriftsartikel (refereegranskat)abstract
- Multicellular spheroids have proven suitable as three-dimensional in vivo-like models of non-vascularized micrometastases. Unlike monolayer-based models, spheroids mirror the cellular milieu and the pathophysiological gradients inside tumor nodules. However, there is limited knowledge of the radiation effects at the molecular level in spheroids of human origin. The present study is a presentation of selected cell biological processes that may easily be analyzed with methods available at routine pathology laboratories. Using gamma irradiated pancreatic neuroendocrine BON1 and colonic adenocarcinoma HCT116 spheroids as model systems, the present study assessed the radiobiological response in these models. Spheroid growth after irradiation was followed over time and molecular responses were subsequently assessed with immunohistochemistry (IHC) staining for descriptive analyses and semi-automatic grading of apoptosis, G(2)-phase and senescence in thin sections of the spheroids. Growth studies demonstrated the BON1 spheroids were slower growing and less sensitive to radiation compared with the HCT116 spheroids. IHC staining for G2-phase was primarily observed in the outer viable P-cell layers of the spheroids, with the 6 Gy irradiated HCT116 spheroids demonstrating a very clear increase in staining intensity compared with unirradiated spheroids. Apoptosis staining results indicated increased apoptosis with increasing radiation doses. No clear association between senescence and radiation exposure in the spheroids were observed. The present results demonstrate the feasibility of the use of multicellular spheroids of human origin in combination with IHC analyses to unravel radiobiological responses at a molecular level. The present findings inspire further investigations, including other relevant IHC-detectable molecular processes in time-and radiation dose-dependent settings.
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| 5. |
- Albertsson, Martin, et al.
(författare)
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Calculated fission-fragment mass yields and average total kinetic energies of heavy and superheavy nuclei
- 2020
-
Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 56:2
-
Tidskriftsartikel (refereegranskat)abstract
- Fission-fragment mass and total-kinetic-energy (TKE) distributions following fission of even-even nuclides in the region 74 ≤ Z≤ 126 and 92 ≤ N≤ 230 , comprising 896 nuclides have been calculated using the Brownian shape-motion method. The emphasis is the region of superheavy nuclei. To show compatibility with earlier results the calculations are extended to include earlier studied regions. An island of asymmetric fission is obtained in the superheavy region, 106 ≤ Z≤ 114 and 162 ≤ N≤ 176 , where the heavy fragment is found to be close to 208Pb and the light fragment adjusts accordingly. Most experimentally observed α-decay chains of superheavy nuclei with Z> 113 terminate by spontaneous fission in our predicted region of asymmetric fission. In these cases, the pronounced large asymmetry is accompanied by a low TKE value compatible with measurements.
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| 6. |
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| 7. |
- Andersson, Karl, 1972-
(författare)
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Characterization of Biomolecular Interactions Using a Multivariate Approach
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents a novel bioinformatic methodology denoted the bio-chemometric approach. The methodology is designed for generation of detailed descriptions and predictions of biomolecular interactions. It is based on multivariate analysis of the sensitivity of a biomolecular interaction to multiple minor changes in the experimental conditions. In this work, either the chemical environment where the interaction takes place, or the molecular structure of one of the interacting molecules, was varied. The sensitivity of the interaction to the performed variations was presented as a vector called the sensitivity fingerprint. The bio-chemometric approach was tested on several biomolecular interactions. Useful descriptions of the interactions were obtained by measuring binding kinetics for each interaction in 12-20 different buffers and correlating buffer composition to binding kinetics. The obtained chemical sensitivity fingerprints were reproducible, significantly different and showed a weak correlation to binding site properties for the tested interactions. The results indicate that the fingerprints contained useful information about the binding site. The predictive ability of the bio-chemometric approach was tested on two different biomolecular interactions where one of the binding partners was slightly modified into multiple analogues by amino acid exchanges. In one example, interactions of 18 peptide analogues with an antibody gave data that could be used for accurate prediction of the dissociation rates of novel analogues. Reliable predictions of binding kinetics and affinity were also obtained for single domain camel antibody analogues binding to a protein antigen. By using the three-dimensional structure of camel antibodies and data obtained using the bio-chemometric approach, even the importance of non-exchanged amino acids for the binding could be estimated. The bio-chemometric approach can potentially improve the development of peptides and proteins for therapeutic and diagnostic use. It is suggested to be valid for general use in biochemistry.
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| 8. |
- Andersson, Lise-Lotte, et al.
(författare)
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Extensive Gamma-ray Spectroscopy of Normally and Superdeformed Structures in 61Cu
- 2008
-
Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 36:3, s. 251-278
-
Tidskriftsartikel (refereegranskat)abstract
- A largely extended experimental knowledge of the Cu-61(29)32 nucleus has been obtained from three experiments. Excited states in Cu-61 were produced via the fusion-evaporation reaction Si-28(Ar-36, 3p)Cu-61. In addition to the Ge array GAMMASPHERE, neutron and charged-particle detectors placed around the target position were used for high-performance particle spectroscopy. The constructed level scheme includes more than 160 energy levels and 320 gamma-ray transitions belonging to both normally deformed as well as superdeformed rotational structures. The multipolarities have been determined for the gamma-ray transitions and as a result spin-parity assignments are given for nearly all energy levels. Experimental results in the normally deformed region are compared with predictions from large-scale shell model calculations. The collective structures are compared with results from cranked Nilsson-Strutinsky calculations. The results reveal the need to modify the standard Nilsson parameters in the mass A similar to 60 region.
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| 9. |
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| 10. |
- Anna, Carlsson, et al.
(författare)
-
Olyckor och skador hos rollatoranvändare i trafikmiljön. Oral presentation vid Transportforum i Linköping den 8-9 januari 2020.
- 2020
-
Ingår i: Transportforum i Linköping, konferens.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bakgrund Rollatorn uppfanns 1978 i Västerås av Aina Wifalk. Idag är Sverige det rullator-tätaste landet i världen och det förskrivs ca 60 000 rullatorer per år. SCB beräknade 2007 att 240 000 personer använde rollator, bland dem ingick var tredje person över 80 år. 2014 fanns 499 000 personer i åldern 80+ i Sverige, år 2030 beräknas antalet ha ökat till 826 000 och 2060 så många som 1 210 000. Om kvoten rollatoranvändare kvarstår kan vi alltså år 2060 räkna med 720 000 rollatoranvändare, bara i åldersgruppen 80+. Användare av rollatorer tillhör gruppen oskyddade trafikanter, men är sällan uppmärksammade i trafiksäkerhetskontexten. Syftet med studien är därför att analysera olycks- och skadedata, som inrapporterats till den nationella databasen STRADA, där användare av rollatorer varit involverade. Resultatet av studien ger värdefull kunskap om risker och hinder som användare av rollator utsätts för i olika typer av trafikmiljöer. Syftet är också att studien ska kunna bidra till att förbättra rörligheten för denna grupp på lång sikt. Metod Studien baseras på olycks- och skadedata från totalt 2 020 rapporterade olyckor med rollator. Inledningsvis undersöktes om antalet rollatorolyckor ökar, minskar eller är konstant över tid. Därefter registrerades varje olycka som antingen ”singel” (N=1 668) eller ”kollision” (N=352). Resultat och slutsats Studien visade på en nästan fördubbling av antalet rollatorrelaterade olyckor i Sverige under perioden 2007–2016. Vidare var ca tre gånger fler kvinnor än män involverade i olyckor med rollator. I en majoritet av singelolyckorna slog användaren i marken. Många av singelolyckorna orsakades av nivåskillnader/kanter, ojämnt underlag eller snubbling. Bilar, lastbilar eller bussar var inblandade i 79% av kollisionerna. Dessa inträffade ofta vid parkeringsplatser, korsningar eller vägsträcka; i många av fallen blev rollatoranvändaren påbackad.
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| 11. |
- Behrendtz, Jörgen, 1972-, et al.
(författare)
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Retro-mediation, Commodore 64, and Interoperational Devices
- 2022
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Ingår i: Artifact & Apparatus: Journal of Media Archaeology. ; :2, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- While research on retrocomputing has stressed the cultural importance of learning from practices such as retrogaming and preservation, this article emphasizes the material practices developed within retrocomputing communities, namely the electronic engineering of various hardware, which seeks to make older technologies operative in a present media ecology. Focusing on hardware designs for the Commodore 64, this articles analyzes their (joint and emergent) media specificities, raising the issue of what is, in fact, being "re-presenced." Wolfgang Ernst's diagrammatic media archaeography serves as a guiding method to produce materially grounded insights into the temporal transformation of digital culture and how chronologically disconnected functionalities tied to specific machinery can, when systematically joined, bridge, erase, or transform the relation between new and old media.
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| 12. |
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| 13. |
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| 14. |
- Bohl Kullberg, Erika, et al.
(författare)
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Development of EGF-conjugated liposomes for targeted delivery of boronated DNA-binding agents
- 2002
-
Ingår i: Bioconjugate chemistry. - : American Chemical Society (ACS). - 1043-1802 .- 1520-4812. ; 13:4, s. 737-743
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Tidskriftsartikel (refereegranskat)abstract
- Liposomes are of interest as drug delivery tools for therapy of cancer and infectious diseases. We investigated conjugation of epidermal growth factor, EGF, to liposomes using the micelle-transfer method. EGF was conjugated to the distal end of PEG−DSPE lipid molecules in a micellar solution and the EGF−PEG−DSPE lipids were then transferred to preformed liposomes, either empty or containing the DNA-binding compound, water soluble acridine, WSA. We found that the optimal transfer conditions were a 1-h incubation at 60 °C. The final conjugate, 125I-EGF−liposome−WSA, contained approximately 5 mol % PEG, 10−15 EGF molecules at the liposome surface, and 104 to 105 encapsulated WSA molecules could be loaded. The conjugate was shown to have EGF-receptor-specific cellular binding in cultured human glioma cells.
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| 15. |
- Bohl Kullberg, E, et al.
(författare)
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Introductory experiments on ligand liposomes as delivery agents for boronneutron capture therapy
- 2003
-
Ingår i: International Journal of Oncology. - 1019-6439 .- 1791-2423. ; 23:2, s. 461-467
-
Tidskriftsartikel (refereegranskat)abstract
- Liposomes are, when coupled to receptor ligands, candidates for receptor mediated delivery of boron for tumour therapy since they have capacity to deliver large amounts of boron per receptor interaction. With EGF-liposomes we present a pegylated ligand liposome delivery vehicle, containing water soluble boronated phenanthridine, WSP1, or water soluble boronated acridine, WSA1, for EGFR targeting. In the case of WSA1 a ligand dependent uptake was obtained and the boron uptake was as good as if free WSA1 was given. No ligand dependent boron uptake was seen for WSP1 containing liposomes. Thus, WSA1 is a candidate for further studies. Approximately 10(5) boron atoms were in each liposome. A critical assessment indicates that after optimization up to 10(6) boron atoms can be loaded. Since it is known that, for therapeutic effect, approximately 10(8)-10(9) boron atoms are needed in a single tumour cell it is realized that 10(2)-10(3) receptor interactions are needed to meet the demand. Tests applying cultured glioma cells indicate, without optimization of the delivery conditions, a boron uptake in the ppm range, which is necessary for successful BNCT. Thus, it seems possible to kill micro-invasive tumour cells with targeted liposomes if the delivery conditions are optimal.
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| 16. |
- Bruskin, Alexander, et al.
(författare)
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Radiobromination of monoclonal antibody using potassium [76Br] (4 isothiocyanatobenzyl-ammonio)-bromo-decahydro-closo-dodecaborate (Bromo-DABI)
- 2004
-
Ingår i: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 31:2, s. 205-11
-
Tidskriftsartikel (refereegranskat)abstract
- The use of charged linkers in attaching radiohalogens to tumor-seeking biomolecules may improve intracellular retention of the radioactive label after internalization and degradation of targeting proteins. Derivatives of polyhedral boron clusters, such as closo-dodecaborate (2-) anion, might be possible charged linkers. In this study, a bifunctional derivative of closo-dodecaborate, (4-isothiocyanatobenzyl-ammonio)-undecahydro-closo-dodecaborate (DABI) was labeled with positron-emitting nuclide (76)Br (T 1/2 = 16.2 h) and coupled to anti-HER2/neu humanized antibody Trastuzumab. The overall labeling yield at optimized conditions was 80.7 +/- 0.6%. The label was proven to be stable in vitro in physiological and a set of denaturing conditions. The labeled antibody retained its capacity to bind to HER-2/neu antigen expressing cells. The results of the study demonstrated feasibility for using derivatives of closo-dodecaborate in indirect labeling of antibodies for radioimmunoPET.
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| 17. |
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| 18. |
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| 19. |
- Carlsson, Axel C, et al.
(författare)
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10-Year Associations between Tumor Necrosis Factor Receptors 1 and 2 and Cardiovascular Events in Patients with Stable Coronary Heart Disease : A CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) Trial Substudy.
- 2018
-
Ingår i: Journal of the American Heart Association. - 2047-9980. ; 7:9
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We aimed to assess the associations and predictive powers between the soluble receptors for tumor necrosis factor (TNF)-α (TNFR1 and TNFR2) and cardiovascular outcomes in patients with stable coronary heart disease.METHODS AND RESULTS: CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) is a randomized clinical trial comparing clarithromycin with placebo in patients with stable coronary heart disease. The primary outcome was a composite of nonfatal acute myocardial infarction, unstable angina pectoris, cerebrovascular disease, and all-cause mortality. Patients were followed up for 10 years; discovery sample, those assigned placebo (1204 events in n=1998); and replication sample, those assigned clarithromycin (1220 events in n=1979). We used Cox regression adjusted for C-reactive protein level, established cardiovascular risk factors, kidney function, and cardiovascular drugs. After adjustments, higher serum levels of TNFR1 and TNFR2 were associated with the composite outcome in the discovery sample (hazard ratio per SD increase, 1.13; 95% confidence interval, 1.05-1.22; P=0.001 for TNFR1; hazard ratio, 1.16; 95% confidence interval, 1.08-1.24; P<0.001 for TNFR2). The associations were similar in the replication sample. The associations with the composite outcome were mainly driven by acute myocardial infarction, cardiovascular mortality, and noncardiovascular mortality. The addition of TNFR1 and TNFR2 to established cardiovascular risk factors improved prediction only modestly (<1%).CONCLUSIONS: Increased concentrations of circulating TNFR1 and TNFR2 were associated with increased risks of cardiovascular events and mortality in patients with stable coronary heart disease. Yet, the utility of measuring TNFR1 and TNFR2 to improve risk prediction in these patients appears limited.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00121550.
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| 20. |
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| 21. |
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| 22. |
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| 23. |
- Carlsson, Anna K, 1966, et al.
(författare)
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Acute injuries resulting from accidents involving powered mobility devices (PMDs)-Development and outcomes of PMD-related accidents in Sweden
- 2019
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Ingår i: Traffic Injury Prevention. - : Informa UK Limited. - 1538-9588 .- 1538-957X. ; 20:5, s. 484-491
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Powered mobility devices (PMDs) are commonly used as aids for older people and people with disabilities, subgroups of vulnarable road users (VRUs) who are rarely noted in traffic safety contexts. However, the problem of accidents involving PMD drivers has been reported in many countries where these vehicles have become increasingly popular.The aim of this study is to extract and analyze national PMD-related accident and injury data reported to the Swedish Traffic Accident Data Acquisition (STRADA) database. The results will provide valuable insight into the risks and obstacles that PMD drivers are exposed to in the traffic environment and may contribute to improving the mobility of this group in the long term.Methods: The current study is based on data from 743 accidents and 998 persons. An analysis was performed on a subset of data (N=301) in order to investigate the development of accidents over a period of 10 years. Thereafter, each accident in the whole data set was registered as either single (N=427) or collision (N=315).Results: The results show that there was a 3-fold increase in the number of PMD-related accidents reported to STRADA during the period 2007-2016.With regard to single accidents, collisions, as well as fatalities, the injury statistics were dominated by males. Single accidents were more common than collisions (N=427 and N=316, respectively) and the level of injury sustained in each type of accident is on par. The vast majority of single accidents resulted in the PMD driver impacting the ground (87%), due to either PMD turnover (71%) or the driver falling out of the PMD (16%). The reason for many of the single accidents was a difference in ground level (34%, typically a curb).Cars, trucks, or buses were involved in 67% of collision events; these occured predominantly at junctions or intersections (70%).Abbreviated Injury Scale (AIS) 3+ injuries were dominated by hip and head injuries in both single accidents and collision events.Conclusions: The present study shows that further research on PMD accidents is required, with regard to both single accidents and collision events. To ensure that appropriate decisions are made, future work should follow up on injury trends and further improve the quality of PDM-related accident data. Improved vehicle stability and design, increased usage of safety equipment, proper training programs, effective maintenance services, and development of a supporting infrastructure would contribute to increased safety for PMD drivers.
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| 24. |
- Carlsson, Anna K, 1966, et al.
(författare)
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Rollator related pedestrian single accidents and collision events in Sweden
- 2022
-
Ingår i: Traffic Safety Research (TSR). - : Lund University. - 2004-3082. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Rollators (four-wheel walkers in USA; zimmer frames in UK) are commonly used as mobility aids for the elderly and people with a variety of disabilities. Pedestrian rollator users are a sub-group of Vulnerable Road Users (VRUs), although this group is rarely recognised in traffic safety contexts. The aim of this study is to extract and analyse rollator related pedestrian accident and injury data in Sweden. The results will provide valuable insight into the risks and obstacles rollator users are exposed to in the traffic environment and may in the long term contribute to improving the mobility of this group. The current study is based on data from 2,020 accidents involving 2,305 persons extracted from the Swedish Traffic Accident Data Acquisition (STRADA) database. For consistency reasons, a subset of data (N = 745) was analysed in order to investigate the development of accidents over a period of 10 years. Thereafter, each accident in the whole data set was registered as either single or collision. The results show that the number of rollator accidents in Sweden increased by approximately 80% during 2007–2016. Females dominate the injury statistics of single accidents, collisions, as well as fatal outcome, which may be due to exposure and/or differences in physical characteristics. Single accidents are much more common than collisions (n=1,668 and n=352, respectively) and the injury consequences are at least as serious. Data from the present study have revealed that the frequency of minor injuries (ISS 1–3) is 4.3 times, moderate (ISS 4–8) 6.0 times and serious injuries (ISS 9–15) 8.9 times higher in single accidents than in collisions. Fatal injuries are, however, more common in collision events (33 in comparison to 8). The vast majority of single accidents (99%) was due to falls. Many of the single accidents (29%) were caused by ground level differences (typically a curb) or due to surface conditions (19%). Collisions involved cars, trucks or buses in 91% of cases, occurring predominantly in car parks (31%) and on (zebra) crossings (30%). In 54% of cases the vehicles reversed into the rollator. Abbreviated Injury Scale (AIS) 3+ injuries were dominated by head (36%) and torso (33%) injuries in collision events, and hip fractures (71%) in single accidents. The present study shows that further research into rollator user related accidents, both single accidents and collision events, is required. In order to introduce appropriate measures, future work should follow up on accident and injury developments and further improve the quality of mobility aid related accident data in general. Improved stability and design, proper training programmes, effective maintenance services, development of a supporting infrastructure would contribute to increased safety for rollator users.
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| 25. |
- Carlsson, Anna, et al.
(författare)
-
Olyckor och skador hos rollatoranvändare i trafikmiljön
- 2020
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bakgrund: Rollatorn uppfanns 1978 i Västerås av Aina Wifalk. Idag är Sverige det rullator-tätaste landet i världen och det förskrivs ca 60 000 rullatorer per år. SCB beräknade 2007 att 240 000 personer använde rollator, bland dem ingick var tredje person över 80 år. 2014 fanns 499 000 personer i åldern 80+ i Sverige, år 2030 beräknas antalet ha ökat till 826 000 och 2060 så många som 1 210 000. Om kvoten rollatoranvändare kvarstår kan vi alltså år 2060 räkna med 720 000 rollatoranvändare, bara i åldersgruppen 80+.Användare av rollatorer tillhör gruppen oskyddade trafikanter, men är sällan uppmärksammade i trafiksäkerhetskontexten. Syftet med studien är därför att analysera olycks- och skadedata, som inrapporterats till den nationella databasen STRADA, där användare av rollatorer varit involverade. Resultatet av studien ger värdefull kunskap om risker och hinder som användare av rollator utsätts för i olika typer av trafikmiljöer. Syftet är också att studien ska kunna bidra till att förbättra rörligheten för denna grupp på lång sikt.Metod: Studien baseras på olycks- och skadedata från totalt 2 020 rapporterade olyckor med rollator. Inledningsvis undersöktes om antalet rollatorolyckor ökar, minskar eller är konstant över tid. Därefter registrerades varje olycka som antingen ”singel” (N=1 668) eller ”kollision” (N=352).Resultat och slutsats: Studien visade på en nästan fördubbling av antalet rollatorrelaterade olyckor i Sverige under perioden 2007–2016. Vidare var ca tre gånger fler kvinnor än män involverade i olyckor med rollator. I en majoritet av singelolyckorna slog användaren i marken. Många av singelolyckorna orsakades av nivåskillnader/kanter, ojämnt underlag eller snubbling. Bilar, lastbilar eller bussar var inblandade i 79% av kollisionerna. Dessa inträffade ofta vid parkeringsplatser, korsningar eller vägsträcka; i många av fallen blev rollatoranvändaren påbackad.
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| 26. |
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Carlsson, Fredrik, 1974-, et al.
(författare)
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Strong clustering in a SNP study of Phlebiopsis gigantea in sweden
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The population structures of wood decaying basidomycetes depend on several factors; one is dispersal pattern of spores, another is age structure including lifespan and also environmental impacts like forest fires. Phlebiopsis gigantea has been shown to be in the group of basidomycetes that have a well developed tolerance to heat, is long-distance wind dispersed and whose fruit body show up early in succession on fallen logs. In a study of 132 individuals from 3 pairs of locations, 350 km apart, in middle to northern Sweden we used 26 SNP-markers in 6 loci to make a genetic clustering study using STRUCTURE (v. 2.3.4.). The hypothesis; first, clustering should follow the geographic sampling locations with more gene flow between geographically close locations, second; that genetic distance between different clusters should be low due to the long distance dispersal of spores, third; as markers are random we don’t expect to find a correlation between locations affected by forest fires and locations not affected by forest fires. In the study we found 5 clusters (Pr[K= 1]) with moderate to high Fst values (0,0697-03939). Clusters had a poor geographical correlation to sampled populations indicating a complicated population structure. Out of 132 individuals 119 had a private genotype showing a large genetic variation over the total area and a low level of clones in the field.
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| 31. |
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| 32. |
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| 33. |
- Carlsson, Jörgen
(författare)
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Computational strategies in flame-spread modelling involving wooden surfaces
- 2003
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Various approaches to flame-spread and fire-growth modelling are discussed and are evaluated using experimental results from different tests. Use of Computational Fluid Dynamics, CFD, in fire modelling is discussed and the performance of different CFD codes in wall flow modelling is analysed. Different pyrolysis models are discussed with respect to their major assumptions and the input data required.
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| 34. |
- Carlsson, Jörgen, et al.
(författare)
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Conjugate chemistry and cellular processing of EGF-dextran
- 1999
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 313-321
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Tidskriftsartikel (refereegranskat)abstract
- Conjugates with specific binding to the epidermal growth factor receptor, EGFR, of interest for radionuclide based imaging and therapy were prepared using mouse epidermal growth factor, mEGF, and dextran. In one type of conjugate, mEGF was coupled to dextran by reductive amination in which the free amino group on the mEGF N-terminal reacted with the aldehyde group on the reductive end of dextran. The end-end coupled conjugate could be further activated by the cyanopyridinium agent CDAP, thereby introducing tyrosines to the dextran part. In the other type of conjugate, the cyanylating procedure using CDAP was applied, first to activate dextran and then allowing for the amino terminus of mEGF to randomly attach to the dextran. In the latter case, radionuclide-labelled tyrosines or glycines could be added in the same conjugation step. All types of mEGF-dextran conjugates had EGFR-specific binding since the binding could be displaced by an excess of non-radioactive mEGF. The conjugates were to a large extent internalized in the test cells and the associated radioactivity was retained intracellularly for different times depending on both the type of cells and conjugate applied. Different intracellular 'traffic routes' for the radionuclides are discussed as well as applications for both imaging and therapy.
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| 35. |
- Carlsson, Jörgen, 1944-
(författare)
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Developmental trends in targeted radionuclide therapy : Biological aspects
- 2008
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Ingår i: Targeted Radionuclide Tumor Therapy. - New York : Springer. - 9781402086953 ; , s. 387-398
-
Bokkapitel (populärvet., debatt m.m.)abstract
- Targeted radionuclide therapy of hematopoietic malignancies in the clinical setting has been achieved and similar successes with solid tumors and cells disseminated from them are likely within reach. Recombinant technologies have led to the development of a number of new targeting agents and the evaluation of a number of putative new targets is currently in progress. These advances are currently under evaluation in the preclinical setting and are expected to transition into clinical trials before long. Many of these new agents exhibit both improved pharmacological properties and enhanced cellular retention, both of which may lead to substantial improvements over existing compounds. In addition, our knowledge of basic radiobiology and its impact on the different modes of cell death is rapidly expanding, leading to new understanding in the fundamental differences between hematopoietic and epithelial tumor cells. Such knowledge will likely have a significant influence on the development of future treatment modalities. Furthermore, the complex interactions between radiation induced intracellular signaling pathways and the crucial observation that low dose radiation (e.g. less than 15 Gy) is able to significantly affect the growth of disseminated solid tumors cells suggests to us that a new era in targeted radionuclide therapy may soon be here.
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| 36. |
- Carlsson, Jörgen
(författare)
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Effects of low dose-rate radiation on cellular survival
- 2008
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Ingår i: Targeted Radionuclide Tumor Therapy. - New York : Springer. - 9781402086953 ; , s. 295-310
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Bokkapitel (populärvet., debatt m.m.)abstract
- The experience of external radiotherapy can only to a limited extent be used to understand therapeutic effects of radionuclide therapy. A major difference is that the dose-rate at radionuclide therapy is at least two orders of magnitude lower. Part of this chapter deals with estimates of the necessary dose-rate and exposure time in combination in order to deliver therapeutic effects to tumour cells. It is proposed that combinations of about 0.1–0.2 Gy/h for several days or about 1 Gy/h for at least 1 day is necessary. Such dose-rates can be achieved with the help of cross fire radiation. Effects of radionuclide therapy in terms of apoptosis, cell-cycle blocks and hyperradiosensitivity are also discussed.
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| 37. |
- Carlsson, Jörgen, et al.
(författare)
-
EGFR-expression in primary urinary bladder cancer and corresponding metastases and the relation to HER2-expression. On the possibility to target these receptors with radionuclides
- 2015
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Ingår i: Radiology and Oncology. - : Walter de Gruyter GmbH. - 1318-2099 .- 1581-3207. ; 49:1, s. 50-58
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Tidskriftsartikel (refereegranskat)abstract
- Background. There is limited effect of tyrosine kinase inhibitors or "naked" antibodies binding EGFR or HER2 for therapy of metastasized urinary bladder canter and these methods are therefore not routinely used. Targeting radionuclides to the extracellular domain of the receptors is potentially a better possibility. Methods. EGFR- and HER2-expression was analyzed for primary tumors and corresponding metastases from 72 patients using immunohistochemistry and the internationally recommended HercepTest. Intracellular mutations were not analyzed since only the receptors were considered as targets and intracellular abnormalities should have minor effect on radiation dose. Results. EGFR was positive in 71% of the primary tumors and 69% of corresponding metastases. Local and distant metastases were EGFR-positive in 75% and 66% of the cases, respectively. The expression frequency of HER2 in related lesions was slightly higher (data from previous study). The EGFR-positive tumors expressed EGFR in metastases in 86% of the cases. The co-expression of EGFR and HER2 was 57% for tumors and 53% for metastases. Only 3% and 10% of the lesions were negative for both receptors in tumors and metastases, respectively. Thus, targeting these receptors with radionuclides might be applied for most patients. Conclusions. At least one of the EGFR- or HER2-receptors was present in most cases and co-expressed in more than half the cases. It is therefore interesting to deliver radionuclides for whole-body receptor-analysis, dosimetry and therapy. This can hopefully compensate for resistance to other therapies and more patients can hopefully be treated with curative instead of palliative intention.
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| 38. |
- Carlsson, Jörgen, 1944-
(författare)
-
EGFR-family expression and implications for targeted radionuclide therapy
- 2008
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Ingår i: Targeted Radionuclide Therapy. - New York : Springer. - 9781402086953 ; , s. 25-58
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Summary High expression in the primary tumor of receptors in the EGFR-family is most often also accompanied by a similar high expression in corresponding metastases. This makes these receptors interesting as putative targets for targeted radionuclide therapy of metastases and disseminated tumor cells. The expression of all four family members, EGFR, HER2, HER3 and HER4 is reviewed in this chapter. Studies on breast, urinary bladder, colorectal, prostate, head and neck, esophageal and glioma tumors are described and possible strategies for targeted radionuclide therapy are discussed. Quantification of receptor expression and the possible influence of genomic stability on the expression are also discussed.
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| 39. |
- Carlsson, Jörgen, et al.
(författare)
-
En historia om koncernredovisning: Den Stockholm-Göteborgska drabbningen
- 2023
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Ingår i: Balans Fördjupning.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Debatten om redovisningsfrågor har numera flyttat från den nationella till den internationella arenan och får inte längre så mycket utrymme i Sverige. Annorlunda var det på 1970-, 1980- och 1990-talen då inte minst tidskriften Balans utgjorde en viktig arena för samtalet om redovisningens utveckling, skriver Jörgen Carlsson och Niklas Sandell vid Ekonomihögskolan i Lund. I sin artikel lyfter de fram ett färgstarkt exempel på hur det kunde låta när svenska redovisningsspecialister debatterade koncernredovisning i början av 1990-talet.
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| 40. |
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| 41. |
- Carlsson, Jörgen, et al.
(författare)
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HER2 expression in breast cancer primary tumours and corresponding metastases : Original data and literature review
- 2004
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 90:12, s. 2344-2348
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to evaluate whether the HER2 expression in breast cancer is retained in metastases. The HER2 expression in primary tumours and the corresponding lymph node metastases were evaluated in parallel samples from 47 patients. The HercepTest was used for immunohistochemical analyses of HER2 overexpression in all cases. CISH/FISH was used for analysis of gene amplification in some cases. HER2 overexpression (HER2-scores 2+ or 3+) was found in 55% of both the primary tumours and of the lymph node metastases. There were only small changes in the HER2-scores; six from 1+ to 0 and one from 3+ to 2+ when the metastases were compared to the corresponding primary tumours. However, there were no cases with drastic changes in HER2 expression between the primary tumours and the corresponding lymph node metastases. The literature was reviewed for similar investigations, and it is concluded that breast cancer lymph node metastases generally overexpress HER2 to the same extent as the corresponding primary tumours. This also seems to be the case when distant metastases are considered. It has been noted that not all patients with HER2 overexpression respond to HER2-targeted Trastuzumab treatment. The stability in HER2 expression is encouraging for efforts to develop complementary forms of therapy, for example, therapy with radionuclide-labelled Trastuzumab.
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| 42. |
- Carlsson, Jörgen
(författare)
-
Introduction to radionuclide therapy
- 2008
-
Ingår i: Targeted Radionuclide Tumor Therapy. - New York : Springer. - 9781402086953 ; , s. 1-11
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This introductory chapter is written for those who are new to the field and desire a short overview of the present status of clinical and preclinical radionuclide therapy. In particular, this chapter provides an overview of the radiophysical concepts and key aspects of dosimetry and treatment planning that are beyond the scope of this book’s focus on biological aspects of radionuclide therapy. Finally, a discussion on the choice of radionuclides and the availability of radiopharmaceuticals is provided.
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| 43. |
- Carlsson, Jörgen, et al.
(författare)
-
Kommunala koncerner : En studie av bolagsstrukturer, budgetar och ägardirektiv
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Utvecklingen mot mer komplicerade kommunala koncerner förändrar förutsättningarna för och ställer andra krav på kommunal koncernstyrning. Syftet med denna studie är att kartlägga dels hur de kommunala koncernerna i Skånes kommuner är strukturerade, dels hur den formella styrningen av dessa koncerner är utformad. Fokus är på andra organisationsformer i den kommunala koncernen än nämnds- och förvaltningsorganisationen, särskilt bolag och kommunalförbund. Rapporten har delats in i två delar: Koncernstrukturer och Styrdokument.
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| 44. |
- Carlsson, Jörgen, et al.
(författare)
-
Koncernredovisning
- 2010
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Denna bok beskriver och förklarar koncernredovisningens logik och teknik. Syftet är att både skapa principiell förståelse för koncernen som redovisningsenhet och god kunskap i koncernredovisningens teknik. Bokens innehåll kan sammanfattas i följande punkter: •Koncernredovisningsteknik •Koncernredovisningslogik •Lagar och regler •Analys av koncernredovisning Koncernredovisning innehåller rikligt med strukturerade och lättillgängliga exempel och övningar. Med boken följer ett lösningshäfte som innehåller utförliga lösningar till samtliga övningsuppgifter. Stora delar av boken har skapats i utbildningssammanhang och grundar sig på erfarenheter från lärosalen. De pedagogiska insikterna kompletteras av författarnas praktiska erfarenheter av koncernredovisning i såväl stora som små företag. Boken är lämplig för utbildning vid universitet och högskolor samt annan kvalificerad utbildning. Den vänder sig även till praktiker som vill lära sig eller repetera grundläggande koncernredovisning.
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| 45. |
- Carlsson, Jörgen, et al.
(författare)
-
Koncernredovisning
- 2014
-
Bok (övrigt vetenskapligt/konstnärligt)
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| 46. |
- Carlsson, Jörgen, et al.
(författare)
-
Koncernredovisning
- 2018. - 3
-
Bok (populärvet., debatt m.m.)abstract
- Denna bok beskriver och förklarar koncernredovisningens logik och teknik. Syftet är att både skapa principiell förståelse för koncernen som redovisningsenhet och god kunskap i koncernredovisningens teknik.
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| 47. |
- Carlsson, Jörgen, et al.
(författare)
-
Koncernredovisning
- 2024. - 4
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Bok (populärvet., debatt m.m.)
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| 48. |
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| 49. |
- Carlsson, Jörgen, et al.
(författare)
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Mandolin AB : Ett praktikfall i redovisning och ekonomisk analys
- 2023. - 1
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Bok (populärvet., debatt m.m.)abstract
- Mandolin AB är ett praktikfall i bokföring, bokslut och ekonomisk analys. I praktikfallet ingår att sköta den löpande bokföringen, ta fram bokslut och årsredovisning samt att göra ekonomiska analyser av företaget Mandolin AB. Praktikfallet syftar till att ge ett helhetsperspektiv på arbetet med ekonomisk rapportering i ett mindre företag, inklusive praktisk kunskap om och förståelse för bokförings- och bokslutslogik. Praktikfallet innehåller, utöver ett autentiskt bokföringsmaterial, textavsnitt om de sakområden som behandlas samt uppgifts- och arbetsbeskrivningar. Vägledning lämnas till särskilt intressanta eller svåra bokföringsposter och bedömningar.
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| 50. |
- Carlsson, Jörgen, et al.
(författare)
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Nedskrivningsprövning av goodwill: före eller efter skatt?
- 2013
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Ingår i: Balans: tidskrift för redovisning och revision. - 0346-8208. ; 39:4, s. 27-30
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- I artikeln utreds sambandet mellan diskonteringsräntan före och efter skatt och hur detta samband påverkar beräkningar vid nedskrivningsprövning.
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