| 1. |
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| 2. |
- Aitaki, Georgia, 1986-, et al.
(författare)
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Farmer Wants a (Swedish) Wife : White Mobilities in the Reality Romance Show Bonde Söker Fru – Jorden Runt
- 2021
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Ingår i: View. - : The Netherlands Institute for Sound and Vision in collaboration with Utrecht University, Luxembourg University and Royal Holloway University of London. - 2213-0969. ; 10:20, s. 64-82
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Tidskriftsartikel (refereegranskat)abstract
- In this article we discuss discourses of white mobility in reality television, a genre whose problematic post-racial and neoliberal discourses have long been exposed. Moving beyond the widely researched Anglophone media landscapes, we interrogate the discursive construction of white mobilities in the Swedish romance reality show Bonde Söker Fru – Jorden Runt (TV4, 2019-2020) [Farmer Seeks Wife – Around the World] where Swedish North-to-South migrants working as farmers abroad seek a partner from Sweden through the assistance of reality TV. By focusing on the discursive and visual strategies through which the show perpetuates racial hierarchies, we discuss the colonial imaginaries, the absence of border policies (such as residency, employment, or integration), and the significance of individual migratory preferences in the mobility discourses. We identify three forms of white mobility – the tourist, the adventurer, and the philanthropist – and show that migration is depicted as something reversible, an adventure, and a possibility for self-development, rather than a life-long decision with high stakes.
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| 3. |
- Aleman, Soo, et al.
(författare)
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A Risk for Hepatocellular Carcinoma Persists Long-term After Sustained Virologic Response in Patients With Hepatitis C-Associated Liver Cirrhosis
- 2013
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1537-6591 .- 1058-4838. ; 57:2, s. 230-236
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Tidskriftsartikel (refereegranskat)abstract
- Background. The long-term effect of sustained virologic response (SVR) to antiviral therapy on the risk of developing hepatocellular carcinoma (HCC), liver complications, liver-related death, and overall death in hepatitis C virus (HCV)-infected patients with liver cirrhosis is not fully known. Methods. These risks were evaluated during long-term follow-up in 351 patients with HCV-related cirrhosis. One hundred ten patients with SVR, 193 with non-SVR, and 48 who were untreated were included in a multicenter cohort that was initiated in 2001 and prospectively followed up for a mean of 5.3 (SD, 2.8) years. Complementary follow-up data from national registries were used to minimize the loss of patients during follow-up. Results. Six patients with SVR developed HCC at 0.04, 0.64, 2.4, 7.4, 7.4, and 7.6 years, respectively, after achieving SVR. The incidences of HCC, any liver complication, liver-related death, and overall death per 100 person-years were significantly lower in SVR time with 1.0, 0.9, 0.7, and 1.9, compared to 2.3, 3.2, 3.0, and 4.1 in non-SVR and 4.0, 4.9, 4.5, and 5.1 in untreated time. The long-term consequences did not decline significantly after >3 years versus during the first 3 years of follow-up. Conclusions. The risk for HCC, liver decompensation, and death in patients with liver cirrhosis related to HCV was markedly reduced after SVR, but a long-term risk of developing HCC remains for up to 8 years. Cirrhotic patients with HCV who achieve SVR should therefore maintain long-term surveillance for HCC. Future studies aimed to better identify those with remaining long-term risk for HCC are needed.
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| 4. |
- Alfsnes, Kristian, et al.
(författare)
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Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
- 2021
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Ingår i: One Health. - : Elsevier. - 2352-7714. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection.
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| 5. |
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| 6. |
- Axelsson, Lena, et al.
(författare)
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Measuring quality of life in life-threatening illness - content validity and response processes of MQOL-E and QOLLTI-F in Swedish patients and family carers
- 2020
-
Ingår i: Bmc Palliative Care. - : Springer Science and Business Media LLC. - 1472-684X. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Background The McGill Quality of Life Questionnaire - Expanded (MQOL-E) and the Quality of Life in Life-Threatening Illness-Family Carer/Caregiver version (QOLLTI-F) are developed for use with patients facing the end of life and their family carers, respectively. They are also developed for possible use as companion instruments. Contemporary measurement validity theory places emphasis on response processes, i.e. what people feel and think when responding to items. Response processes may be affected when measurement instruments are translated and adapted for use in different cultures. The aim of this study was to translate and examine content validity and response processes during completion of MQOL-E and QOLLTI-F version 2 (v2) among Swedish patients with life-threatening illness and their family carers. Methods The study was conducted in two stages (I) translation and adaptation (II) examination of content validity and response processes using cognitive interviews with 15 patients and 9 family carers. Participants were recruited from the hemodialysis unit, heart clinic, lung clinic and specialized palliative care of a Swedish county hospital. Patients had life-threatening illness such as advanced heart failure, advanced chronic obstructive pulmonary disease, end-stage kidney disease or advanced cancer. Patients were outpatients, inpatients or receiving home care. Results Patients and family carers respectively believed that the items of the MQOL-E and QOLLTI-F v2 reflect relevant and important areas of their quality of life. Although some items needed more time for reflection, both instruments were considered easy to understand. Some changes were made to resolve issues of translation. Participants expressed that reflecting on their situation while answering questions was valuable and meaningful to them, and that responding was an opportunity to express feelings. Conclusions The results of response processes pertaining to the Swedish translations of both MQOL-E and QOLLTI-F v2 contribute evidence regarding content validity, linguistic equivalence and cultural appropriateness of the translated instruments. In addition, results show that the instruments may support conversations on matters of importance for quality of life between patients and/or family carers and health care professionals. Further research is needed to study the psychometric properties of Swedish translations.
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| 7. |
- Bonotti, Matteo, et al.
(författare)
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Introduction : Linguistic justice, migration and the nation‐state
- 2022
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Ingår i: Nations and Nationalism. - : John Wiley & Sons. - 1354-5078 .- 1469-8129. ; 28:2, s. 379-386
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Tidskriftsartikel (refereegranskat)abstract
- This article provides an introduction to the themed section “Linguistic Justice, Migration and the Nation-State.” First, it illustrates the rationale for the themed section by examining the relationship between language, migration and the nation-state. It argues that accounts of linguistic justice that fail to incorporate, discuss and understand the language interests of migrants, and the potential tensions that may emerge between migrants' linguistic rights and duties, and between their linguistic rights and those of autochthonous groups, are likely to become obsolete in an increasingly mobile world. Second, it provides an overview of the articles in the themed section. And, finally, it highlights four specific areas of inquiry that should deserve greater attention in future scholarship.
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| 8. |
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| 9. |
- Carlsson, Maine, 1955-, et al.
(författare)
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Effects of high-intensity exercise and protein supplement on muscle mass in ADL dependent older people with and without malnutrition : a randomized controlled trial
- 2011
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Ingår i: The Journal of Nutrition, Health & Aging. - : Springer Science and Business Media LLC. - 1279-7707 .- 1760-4788. ; 15:7, s. 554-560
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Tidskriftsartikel (refereegranskat)abstract
- Background Loss of muscle mass is common among old people living in institutions but trials that evaluate interventions aimed at increasing the muscle mass are lacking. Objective, participants and intervention This randomized controlled trial was performed to evaluate the effect of a high-intensity functional exercise program and a timed protein-enriched drink on muscle mass in 177 people aged 65 to 99 with severe physical or cognitive impairments, and living in residential care facilities. Design Three-month high-intensity exercise was compared with a control activity and a protein-enriched drink was compared with a placebo drink. A bioelectrical impedance spectrometer (BIS) was used in the evaluation. The amount of muscle mass and body weight (BW) were followed-up at three and six months and analyzed in a 2 × 2 factorial ANCOVA, using the intention to treat principle, and controlling for baseline values. Results At 3-month follow-up there were no differences in muscle mass and BW between the exercise and the control group or between the protein and the placebo group. No interaction effects were seen between the exercise and nutritional intervention. Long-term negative effects on muscle mass and BW was seen in the exercise group at the 6-month follow-up. Conclusion A three month high-intensity functional exercise program did not increase the amount of muscle mass and an intake of a protein-enriched drink immediately after the exercise did not induce any additional effect on muscle mass. There were negative long-term effects on muscle mass and BW, indicating that it is probably necessary to compensate for an increased energy demand when offering a high-intensity exercise program.
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| 10. |
- Carlsson, Nina
(författare)
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Boundaries and Belonging Among Settled Minorities and Refugees in Bulgaria
- 2023
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Ingår i: Nationalities Papers. - : Cambridge University Press. - 0090-5992 .- 1465-3923. ; 51:5, s. 1123-1142
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Tidskriftsartikel (refereegranskat)abstract
- The importance of settled minorities for facilitating refugee belonging is seldom discussed in research on refugee integration. Drawing on scholarship on belonging, boundary-making, and bordering, this study investigates how boundaries are drawn between settled minorities and refugees in Bulgaria. Based on interviews with integration workers and organizations of settled minorities in a state with the largest historically present Muslim minority in the EU, an Arabic-speaking diaspora settled decades ago, and with minimal state involvement in refugee integration, the study shows how spatial, linguistic, and religious boundaries separate settled minorities from newly arrived refugees. Arabic-speaking diasporas are nevertheless witnessed to overcome the boundaries through geographical proximity, a shared language, and shared countries of origin, whereby they have functioned as facilitators of refugee belonging and inclusion. Furthermore, Muslim institutions led by Bulgarian Turks have functioned as spaces for refugee belonging. The study finds that settled minority communities have, despite multiple boundaries and some assimilatory discourses, contributed to refugee belonging in ways that in part has compensated for the state absence. The study calls for further research investigating the role of settled minorities in inclusionary processes in society.
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| 11. |
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| 12. |
- Carlsson, Nina, et al.
(författare)
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Det professionella och sociala stödets betydelse för symtom på förlängd sorg hos närstående till personersom avlidit till följd av hjärtstopp
- 2022
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Konferensbidrag (refereegranskat)abstract
- Bakgrund: Ett palliativt förhållningssätt omfattar uppföljning av närstående vilket ofta saknas vid plötsliga dödsfall. Närstående riskerar då att lämnas utan professionellt stöd med obesvarade frågor, vilket kan bidra till förlängd sorg.Syfte: Att utforska det professionella och sociala stödets betydelse för symtom på förlängd sorg hos närstående till personer som avlidit till följd av plötsligt hjärtstopp.Metod: Denna korrelerande observationsstudie baserades på en enkät till närstående sex och tolv månader efter dödsfallet. Enkäten bestod av bakgrundsfrågor om de närstående, förlusten, och professionellt stöd, samt validerade skattningsskalor för att mäta förlängd sorg (PG-13) och socialt stöd (MSPSS). Data analyserades med regressionsanalyser.Resultat: Deltagarna (n=69) var i genomsnitt 61 år (37–71) och flertalet var kvinnor (67%). Vanligaste relationen till den avlidne var vuxna barn (52%) och efterlevande partner (36%). Vid sex månader skattade de närstående som hade ett professionellt stöd högre symtomnivåer av förlängd sorg än de utan professionellt stöd (B=10,28,p=0,001). Ett signifikant samband fanns även mellan högre socialt stöd och lägre självskattade symtom på förlängd sorg, oavsett om stödet kom från familj (B=-3,24, p=0,001), vänner (B=-2.43, p=0,020) eller andra betydelsefulla personer (B=-2,29, p=0,010). Vid tolv månader kvarstod endast sambandet till professionellt stöd (B=9,05, p=0,020). En majoritet skattade färre eller oförändrade symtom på förlängd sorg vid tolv månader jämfört med sex månader, men en betydande andel skattade högre symptomnivåer (33%).Betydelse: Sambandet mellan professionellt stöd och höga symtomnivåer av förlängd sorg visar på betydelsen av efterlevandestöd. Genom att stödja närstående i kommunikationen med familj och vänner kan det sociala stödet stärkas. För att understödja den närståendes sorgeprocess bör stöd erbjudas i både akut och palliativ kontext.
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| 13. |
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| 14. |
- Carlsson, Nina, 1979-, et al.
(författare)
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Factors Associated With Symptoms of Prolonged Grief and Psychological Distress Among Bereaved Family Members of Persons Who Died From Sudden Cardiac Arrest
- 2023
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Ingår i: Journal of Cardiovascular Nursing. - : Wolters Kluwer. - 0889-4655 .- 1550-5049. ; 38:5, s. 454-461
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Tidskriftsartikel (refereegranskat)abstract
- Background: Death from sudden cardiac arrest implies a stressful and challenging situation for bereaved family members with an increased risk of prolonged grief disorder and psychological distress.Objectives: The aims of this study were (1) to explore the associations between symptoms of prolonged grief and psychological distress and (2) to identify factors associated with symptoms of prolonged grief and psychological distress among bereaved family members of persons who died from sudden cardiac arrest.Methods: This cross-sectional survey included bereaved adult family members. Demographic data and measures of prolonged grief (Prolonged Grief Disorder-13), anxiety and depression (Hospital Anxiety and Depression Scale), posttraumatic stress (Posttraumatic Stress Disorder Checklist for DSM-5), and perceived social support (Multidimensional Scale of Perceived Social Support) were analyzed using Spearman’s correlations (rs) as well as univariate and multiple linear regression analyses.Results: In total, 108 family members participated. Significant associations between symptoms of prolonged grief, anxiety, depression, and posttraumatic stress were identified (rs = 0.69–0.79, P < .001). Offered, sought, and/or received professional support from healthcare, lower levels of perceived social support, being a spouse of the deceased, female sex, younger age, and family presence during resuscitation were significantly associated with higher symptom levels of prolonged grief, anxiety, depression, and/or posttraumatic stress.Conclusions: The results indicate that family members with higher levels of symptoms were offered, sought, and/or received professional support. However, because a minority are offered professional support after deaths from cardiac arrest, future interventions need to proactively identify family members in need of support. Furthermore, perceived social support seems to be an important factor for family members of persons who died from cardiac arrest.
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| 15. |
- Carlsson, Nina, et al.
(författare)
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Factors associated with symptoms of prolonged grief and psychological distress among bereaved family members of persons who died from sudden cardiac arrest
- 2023
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Ingår i: Journal of Cardiovascular Nursing. - 0889-4655 .- 1550-5049. ; 38:5, s. 454-461
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Death from sudden cardiac arrest implies a stressful and challenging situation for bereaved family members with an increased risk of prolonged grief disorder and psychological distress.OBJECTIVES: The aims of this study were (1) to explore the associations between symptoms of prolonged grief and psychological distress and (2) to identify factors associated with symptoms of prolonged grief and psychological distress among bereaved family members of persons who died from sudden cardiac arrest.METHODS: This cross-sectional survey included bereaved adult family members. Demographic data and measures of prolonged grief (Prolonged Grief Disorder-13), anxiety and depression (Hospital Anxiety and Depression Scale), posttraumatic stress (Posttraumatic Stress Disorder Checklist for DSM-5), and perceived social support (Multidimensional Scale of Perceived Social Support) were analyzed using Spearman's correlations (rs) as well as univariate and multiple linear regression analyses.RESULTS: In total, 108 family members participated. Significant associations between symptoms of prolonged grief, anxiety, depression, and posttraumatic stress were identified (rs = 0.69-0.79, P < .001). Offered, sought, and/or received professional support from healthcare, lower levels of perceived social support, being a spouse of the deceased, female sex, younger age, and family presence during resuscitation were significantly associated with higher symptom levels of prolonged grief, anxiety, depression, and/or posttraumatic stress.CONCLUSIONS: The results indicate that family members with higher levels of symptoms were offered, sought, and/or received professional support. However, because a minority are offered professional support after deaths from cardiac arrest, future interventions need to proactively identify family members in need of support. Furthermore, perceived social support seems to be an important factor for family members of persons who died from cardiac arrest.
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| 16. |
- Carlsson, Nina, 1979-, et al.
(författare)
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Grief reactions in relation to professional and social support among family members of persons who died from sudden cardiac arrest : A longitudinal survey study
- 2022
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Ingår i: Resuscitation Plus. - : Elsevier. - 2666-5204. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Background: The loss of a close person from sudden cardiac arrest (CA) leaves family members at risk of developing grief reactions such as symp- toms of prolonged grief, anxiety, depression, and posttraumatic stress. The aim was to describe longitudinal variations in grief reactions and its asso- ciation with professional and social support among bereaved family members after a close person’s death from sudden CA.Methods: This longitudinal multimethod survey included 69 bereaved family members who completed a questionnaire 6 and 12-months after the CA, including the Prolonged Grief Disorder-13, Hospital Anxiety and Depression Scale, PTSD Checklist for DSM-5, and Multidimensional Scale of Perceived Social Support. Qualitative data were collected by open-ended questions. Quantitative data was analyzed using Wilcoxon signed-rank test and linear regression analysis while written comments were analyzed using qualitative content analysis.Results: The median age was 62 years, 67 % were women, and 38 % had been present during the resuscitation attempts. Using the cut-off scores at the 6- and 12-month assessments respectively, 14 % and 17 % reported symptoms of prolonged grief, 32 % and 26 % symptoms of anxiety, 14 % and 9 % depression, and 4 % and 1 % posttraumatic stress. Professional and social support at the 6-month assessment were significantly associ- ated with symptoms of prolonged grief, anxiety, depression, and/or posttraumatic stress at the 12-month assessments but could not predict any changes in the grief reactions.Conclusions: Family members’ grief reactions point to the importance of proactive and available support over time to meet family members’ needs.
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| 17. |
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| 18. |
- Carlsson, Nina, et al.
(författare)
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Losing a close person following death by sudden cardiac arrest : bereaved family members’ lived experiences
- 2022
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Ingår i: Death Studies. - : Taylor & Francis. - 0748-1187 .- 1091-7683. ; 46:5, s. 1139-1148
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Tidskriftsartikel (refereegranskat)abstract
- The death of a close person has profound impact on people’s lives, and when death is sud- den there are no possibilities to prepare for the loss. The study aimed to illuminate mean- ings of losing a close person following sudden cardiac arrest. A qualitative interpretive design was used, and twelve bereaved family members were interviewed. The results show a transition from pending between life and sudden loss during resuscitation and proceeding with life after the sudden loss. These results of being in liminality illuminate the family members’ essential narration and the importance of compassionate care throughout this challenging transition.
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| 19. |
- Carlsson, Nina
(författare)
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Majority nation‐building through language requirements : Minority perspectives from EU27
- 2022
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Ingår i: Nations and Nationalism. - : John Wiley & Sons. - 1354-5078 .- 1469-8129. ; 28:2, s. 465-482
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Tidskriftsartikel (refereegranskat)abstract
- This study contributes with minority-centred perspectives to the policy trend of imposing majority language requirements on immigrants. With the aim to identify and explore (dis)connections and value conflicts between policies of national minority recognition and immigrant integration, it develops and applies four ideal types of minority-linguistic integration regimes to a mapping of integration and minority language policies in 27 European Union (EU) member states. Most states with recognized minorities are found to exclude national minorities from integration policies. The finding is connected to a discussion that identifies normative tensions between the promotion of national minority languages, the linguistic barriers faced by non-citizen migrants and the asymmetries in how identity and instrumental values are assigned to minority, migrant and majority languages. The study challenges the imposition of language requirements on immigrants and calls for contextually sensitive ways to jointly consider the position of national minorities, majorities, and immigrants in language policies.
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| 20. |
- Carlsson, Nina
(författare)
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Navigating Two Languages : Immigrant Integration Policies in Bilingual Finland
- 2017
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Ingår i: Journal on Ethnopolitics and Minority Issues in Europe. - : European Centre for Minority Issues. - 1617-5247. ; 16:2, s. 41-66
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Tidskriftsartikel (refereegranskat)abstract
- Immigration into states with historical linguistic minorities creates the dilemma of which language newly arrived immigrants should learn in the state-provided integration programmes. Research has shown how territorially concentrated historical minorities have used immigrants to favour their own nation-building projects. While these minorities to some extent operate like a majority within their federal state or province, this paper explores how constitutionally bilingual Finland, having a Swedish-speaking non-territorial minority with the same linguistic rights as the majority, governs immigrant integration. It investigates the implications of the strong legal and weak societal status of Swedish for immigrant integration by connecting scholarship on liberal multiculturalism and integration in multilingual states to laws, reports and interviews on integration in Swedish-speaking Finland. It shows tensions between Finland-Swedish integration aspirations and state level policies promoting a majority-monolingual integration. Unlike minorities with federal protection, the non-territorial Swedish-speaking minority largely relies on the voluntary choice of immigrants to choose Swedish as their language of integration. Structural obstacles, however, hinder this choice in bilingual regions, having resulted in political debates and actions. This article bridges research on Finnish multiculturalism and research on integration policy in contexts where historical minorities are present by introducing a non-territorial, formerly dominant minority to the research field.
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| 21. |
- Carlsson, Nina
(författare)
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One Nation, One Language? : National minority and Indigenous recognition in the politics of immigrant integration
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Policies regulating immigrant integration constitute a core element of nation-building through the compliance they prescribe with cultural and linguistic norms. The recognition of multiple national belongings in states with national minorities and Indigenous peoples nevertheless challenges majority-centred notions of what integration should entail. Research on connections between integration and recognition, however, has mainly focused on minority substates such as Quebec and Catalonia, where local integration policies align with the respective minority nationalist project, leaving other contexts of recognition largely unexplored.By employing critical and interpretive approaches to the study of politics, this study aims to explore connections, separations, and synergies between policies of national minority recognition and immigrant integration in Europe. Using a combination of document analysis, interviews, and ethnographic observation, it asks how integration policy produces or counters expressions of majority nationhood in states with recognized minorities, how colonial or imperial legacies shape such policies, and what normative tensions can be identified between the promotion of majority and minority identities. Theoretically, it draws on scholarship on liberal multiculturalism, settler colonial studies, and theories on belonging and boundary-making.The four articles of this compilation dissertation combine empirical findings with normative questions. States with recognized minorities in EU27 are shown to reproduce majority nationhood through integration, which clashes with minority protection and with some migrants’ aspirations. In Finland, where the Swedish-speaking minority enjoys equal linguistic recognition with the majority, the minority and migrants are shown to mobilize to ensure the implementation of minority elements in the predominantly majority-centred integration. In Indigenous Swedish Sápmi, state-led integration is found to largely reproduce colonial practices, which are nevertheless also occasionally challenged. In Bulgaria, Turkish-speaking, Muslim minorities are othered in society and marginal within integration, even though post-Ottoman Muslim institutions have come to function as spaces of belonging for recent refugees.Integration policies are shown to misrecognize minorities and thereby fail to represent the actual heterogeneity faced by migrants. Past and present linguistic, religious, racial, and societal contestations are shown to intersect in complex, layered ways that contemporary monolingual, territory-based models of minority recognition and integration fail to capture. The study’s findings have normative implications for research on minority recognition and integration and call for contextually sensitive perspectives to rethink present policies that serve the goals of majority nation-building rather than mirror actual societal belongings.
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| 22. |
- Carlsson, Nina
(författare)
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Revitalizing the Indigenous, integrating into the colonized? : The banal colonialism of immigrant integration in Swedish Sapmi
- 2020
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Ingår i: Ethnic and Racial Studies. - : Routledge. - 0141-9870 .- 1466-4356. ; 43:16, s. 268-286
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Tidskriftsartikel (refereegranskat)abstract
- In an endeavour to understand connections between immigration policy and contemporary colonialism on Indigenous territory, this study investigates how state-led immigrant integration policies and practices reproduce colonialism in Swedish Sapmi. It explores the applicability of scholarship on settler colonialism on Sweden and develops the notion of banal colonialism by combining scholarship on settler and everyday colonialism with banal nationalism. Drawing from state documents regulating immigrant integration and semi-structured interviews conducted with integration workers in Swedish Sapmi, the study shows that immigrant integration policy largely silences the colonial past and present of Sweden. While the implementation of national-level policies on Indigenous land reproduces majority-centred narratives, also practices challenging the colonial order are identified. The study shows how the notion of banal colonialism captures mundane colonial practices, but also brings attention to instances where immigrant integration policy has the potential of challenging settler colonialism.
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| 23. |
- Carlsson, Nina, 1979-
(författare)
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Sorgereaktioner hos närstående till personer som avlidit till följd av plötsligt hjärtstopp
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Syfte: Avhandlingens övergripande syfte var att utforska sorgereaktioner hos närstående till personer som avlidit till följd av plötsligt hjärtstopp. De specifika syftena var att: belysa innebörder av levda erfarenheter av att förlora en nära person som avlidit till följd av plötsligt hjärtstopp (I), beskriva symtom på förlängd sorg och självskattad hälsa hos närstående, samt att jämföra partners och icke-partners (II), undersöka samband mellan symtom på förlängd sorg och psykisk ohälsa samt identifiera associerade faktorer (III), undersöka sorgereaktioner i relation till socialt och professionellt stöd, sex och tolv månader efter förlusten (IV).Metod: Datainsamlingen genomfördes genom kvalitativa intervjuer (n=12) (I) samt via enkäter sex (n=108) (I-III) och tolv (n=69) (IV) månader efter dödfallet. Enkäterna innehöll bakgrundsfrågor samt mätinstrumenten: Prolonged Grief Disorder (PG-13), RAND-36, Health Index (HI), Minimal Insomnia Symptom Scale (MISS), Hospital Anxiety and Depression Scale (HADS), Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), Multidimensional Scale of Perceived Social Support (MSPSS). Intervjudata analyserades utifrån fenomenologisk hermeneutik (I) och enkätdata analyserades med beskrivande och inferentiell statistik (II-IV).Resultat: Under hjärtstoppshändelsen befann sig närstående i ett gränsland mellan liv och död. Efter dödsfallet var närståendes berättande betydelsefullt i sökandet efter förståelse och mening. Att sakna svar kunde hålla kvar närstående i liminalitet och försvåra sorgeprocessen (I). Var femte närstående (18%) rapporterade symtom på förlängd sorg sex månader efter förlusten. Även symtom på ångest (30%) och depression (19%) var vanligt medan få rapporterade symtom på posttraumatisk stress (6%) (II). Dessa symtom samexisterade i hög grad (rs=0,69-0,79) (III) och kunde även kvarstå eller förvärras över tid (IV). Både socialt och professionellt stöd var signifikant associerat med symtom på förlängd sorg och psykisk ohälsa (III-IV). En majoritet (86%) rapporterade att de inte erbjudits stöd från hälso- och sjukvården vid dödsfallet (II).Slutsats: För att underlätta sorgeprocessen bör närstående erbjudas professionellt stöd under hjärtstoppshändelsen och uppföljande samtal efter dödfallet. Genom ett proaktivt professionellt stöd och användning av validerade mätinstrument kan närstående i behov av ytterligare psykologiskt stöd identifieras.
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| 24. |
- Carlsson, Nina, et al.
(författare)
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Symptoms of prolonged grief and self-reported health among bereaved family members of persons who died in sudden cardiac arrest
- 2023
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Ingår i: Omega. - : Sage Publications. - 0030-2228 .- 1541-3764. ; 87:1, s. 66-86
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Tidskriftsartikel (refereegranskat)abstract
- Sudden cardiac arrest is common and is one of the leading causes of death in the western world, and the sudden loss following cardiac arrest may have a significant impact on bereaved family members’ health. Therefore, the aim of this study was to describe symptoms of prolonged grief and self-reported health among bereaved family members of persons who died from sudden cardiac arrest, with comparisons between spouses and non-spouses. This was a cross-sectional observation study with 108 adult family members who completed a questionnaire. A fifth of the family members reported prolonged grief, and problems with self-reported health were common, especially regarding anxiety. Spouses reported more problems with prolonged grief and self-reported health compared with non-spouses. The risk of these family members developing prolonged grief and health problems should be recognized, and professional support should be offered.
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| 25. |
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| 26. |
- Carlsson, Ninni, 1962, et al.
(författare)
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”Visa i handling vad arbetet mot mäns våld är värt”
- 2019
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Ingår i: Svenska Dagbladet. ; 2019:4 april
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Mitt i debatten om Josefin Nilsson och det våld mot henne som närstående berättar om i SVT-dokumentären ”Älska mig för den jag är”, tillkännager regeringen, C och L att de föreslår 45 miljoner i vårbudget för att bekämpa mäns våld mot kvinnor. Flera medier kallar det en storsatsning men är det verkligen det, frågar våldsforskare, #metoo-upprop och organisationer. Med hjälp av aktuell forskning argumenterar de för att detta är långt ifrån tillräckligt, kräver större vårbudget mot mäns våld mot kvinnor och bjuder in riksdag och regering till dialog.
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Davies, Lindsay C., et al.
(författare)
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Type 1 Diabetes Mellitus Donor Mesenchymal. Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro
- 2016
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Ingår i: Stem Cells Translational Medicine. - : Oxford University Press (OUP). - 2157-6564 .- 2157-6580. ; 5:11, s. 1485-1495
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Tidskriftsartikel (refereegranskat)abstract
- Bone marrow mesenchymal stromal cells (BM-MSCs) have been characterized and used in many clinical studies based on their immunomodulatory and regenerative properties. We have recently reported the benefit of autologous MSC systemic therapy in the treatment of type 1 diabetes mellitus (T1D). Compared with allogeneic cells, use of autologous products reduces the risk of eliciting undesired complications in the recipient, including rejection, immunization, and transmission of viruses and prions; however, comparable potency of autologous cells is required for this treatment approach to remain feasible. To date, no analysis has been reported that phenotypically and functionally characterizes MSCs derived from newly diagnosed and late-stage T1D donors in vitro with respect to their suitability for systemic immunotherapy. In this study, we used gene array in combination with functional in vitro assays to address these questions. MSCs from T1D donors and healthy controls were expanded from BM aspirates. BM mononuclear cell counts and growth kinetics were comparable between the groups, with equivalent colony-forming unit-fibroblast capacity. Gene microarrays demonstrated differential gene expression between healthy and late-stage T1D donors in relation to cytokine secretion, immunomodulatory activity, and wound healing potential. Despite transcriptional differences, T1D MSCs did not demonstrate a significant difference from healthy controls in immunosuppressive activity, migratory capacity, or hemocompatibility. We conclude that despite differential gene expression, expanded MSCs from T1D donors are phenotypically and functionally similar to healthy control MSCs with regard to their immunomodulatory and migratory potential, indicating their suitability for use in autologous systemic therapy.
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| 31. |
- Gabrielsson, Britt, 1957, et al.
(författare)
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Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice
- 2012
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Ingår i: International Journal of Molecular Medicine. - : Spandidos Publications. - 1107-3756 .- 1791-244X. ; 29:3, s. 331-37
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Tidskriftsartikel (refereegranskat)abstract
- Diet is a significant modifiable risk factor for cardiovascular disease and high fish intake has been associated with vascular health in population studies. However, intervention studies have been inconclusive. In this study, male low-density lipoprotein receptor-deficient mice were given 16-week high fat/high sucrose diets, supplemented with either minced herring fillets or minced beef. The diets were matched in total fat and cholesterol content; taurine content and fatty acid composition was analysed. Body weights were recorded throughout the study; plasma lipids were analysed at week 8 and 16. Body composition and adipocyte size were evaluated at study end. Atherosclerosis was evaluated at week 12 (ultrasound) and at termination (en face histology). Herring-fed mice had a higher proportion of long-chain n-3 polyunsaturated fatty acids in the hepatic triacylglycerides (TAG) and phospholipid fractions. The herring-fed mice had increased body weight (P=0.007), and reduced epididymal adipocyte size (P=0.009), despite similar food intake and body composition as the beef-fed mice. The herring-fed mice had lower plasma TAG and very-low-density lipoprotein (VLDL)-cholesterol concentrations throughout the study (TAG; P=0.0012 and 0.004, VLDL-cholesterol; P=0.006 and 0.041, week 8 and 16, respectively). At week 16, the herring-fed had higher plasma concentrations of HDL-cholesterol (P=0.004) and less atherosclerotic lesions in the aortic arch (P=0.007) compared with the beef-fed mice. In conclusion, dietary herring in comparison to beef markedly improved vascular health in this mouse model, suggesting that herring provides an added value beyond its content of macronutrients.
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| 32. |
- Hjorth, Martin, et al.
(författare)
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Thalidomide and dexamethasone vs. bortezomib and dexamethasone for melphalan refractory myeloma: a randomized study.
- 2012
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Ingår i: European journal of haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 88:6, s. 485-496
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objectives: Thalidomide and bortezomib have been frequently used for second-line therapy in patients with myeloma relapsing after or refractory to initial melphalan-based treatment, but no randomized trials have been published comparing these two treatment alternatives. Methods: Thalidomide- and bortezomib-naïve patients with melphalan refractory myeloma were randomly assigned to low-dose thalidomide + dexamethasone (Thal-Dex) or bortezomib + dexamethasone (Bort-Dex). At progression on either therapy, the patients were offered crossover to the alternative drug combination. An estimated 300 patients would be needed for the trial to detect a 50% difference in median PFS between the treatment arms. Results: After inclusion of 131 patients, the trial was prematurely closed because of low accrual. Sixty-seven patients were randomized to Thal-Dex and 64 to Bort-Dex. Progression-free survival was similar (median, 9.0 months for Thal-Dex and 7.2 for Bort-Dex). Response rate was similar (55% for Thal-Dex and 63% for Bort-Dex), but time to response was shorter (P < 0.05) and the VGPR rate higher (P < 0.01) for Bort-Dex. Time-to-other treatment after crossover was similar (median, 13.2 months for Thal-Dex and 11.2 months for Bort-Dex), as was overall survival (22.8 months for Thal-Dex and 19.0 for Bort-Dex). Venous thromboembolism was seen in seven patients and cerebrovascular events in four patients in the Thal-Dex group. Severe neuropathy, reactivation of herpes virus infections, and mental depression were more frequently observed in the Bort-Dex group. In the quality-of-life analysis, no difference was noted for physical function, pain, and global quality of life. Fatigue and sleep disturbances were significantly more prevalent in the Bort-Dex group. Conclusions: Thalidomide (50–100 mg daily) in combination with dexamethasone seems to have an efficacy comparable with that of bortezomib and dexamethasone in melphalan refractory myeloma. However, the statistical strength of the results in this study is limited by the low number of included patients.
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| 33. |
- Johnson, Joakim, et al.
(författare)
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Development and validation of the Gothenburg Trismus Questionnaire (GTQ).
- 2012
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Ingår i: Oral oncology. - : Elsevier BV. - 1368-8375. ; 48:8, s. 730-736
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To develop and validate a comprehensive, self-administered questionnaire for patients with limited ability to open the mouth, trismus. MATERIALS AND METHODS: We derived the Gothenburg Trismus Questionnaire (GTQ) from empirical evidence in the medical literature and interviews with medical experts as well as patients. The draft version was tested in a pilot study (n=18). Patients with a maximal incisal opening (MIO) of ⩽35mm were included. The study comprised patients with benign jaw-related conditions (n=51), patients treated for head and neck (H&N) cancer (n=78) and an age- and gender-matched control group without trismus (n=129). RESULTS: The GTQ instrument was well accepted by the patients, with satisfactory compliance and low rates of missing items. After item reduction, due to items not being conceptually relevant and/or low factor loadings, the GTQ demonstrated high internal consistency (Cronbach's alpha 0.72-0.90), good construct validity and known-group validity. CONCLUSION: We developed a trismus-specific self-administered questionnaire, the GTQ, that showed good psychometric properties. We suggest this questionnaire, that has clear clinical relevance, to be adopted and used in clinical practice and in research, acting as a screening tool as well as an endpoint in intervention and jaw physiotherapy/rehabilitation studies.
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| 34. |
- Kilbrink, Nina, 1974-
(författare)
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Legorobotar i skolan : Elevers uppfattningar av lärandeobjekt och problemlösningsstrategier
- 2008
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study concerns pupils’ experiences of learning and working with programmable robotics at school. Consequently, the study refers to the use of computers at school and can therefore be placed in the research area of computer aided learning. The aim is to analyze and describe pupils’ different experiences of what they learn by means of working with programmable robotics at school and how they experience that they work and solve problems by means of programming and constructing robotics. The first question concerns the experienced object of learning and the second question is about the experienced problem solving strategies. The theoretical framework and method is in the area of phenomenology of the life-world and phenomenography. The pupils who have been interviewed in the study have all been working with a programmable Lego material and the result is the qualitatively different categories of pupils’ experiences of objects of learning and problem solving strategies in relation to this material. Many experiences focus on social aspects of this work, which means that the technological material itself is not the evident object of learning in the pupils’ experiences. Also the experiences related to the problem solving strategies often focus on a social dimension. The findings should be seen as a contribution to the discussion about understanding pupils’ different ways of experiencing their work and learning in technological surroundings and thereby facilitate the creation of an educational environment where pupils can be met at their level and where teachers can create possibilities for holistic learning. This understanding can contribute to evolve the didactics about computers and technology education.
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| 35. |
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| 36. |
- Lagerqvist, Nina, et al.
(författare)
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Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers
- 2021
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated the performance of 11 SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had a specificity of 99.0% and a sensitivity that ranged from 56.3 to 81.6% and decreased with low IFA IgG titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected ≥ 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations.
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| 37. |
- Larsson, Billy, 1956, et al.
(författare)
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Klimatfrågan kräver en ny global etik
- 2012
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Ingår i: Göteborgs Posten. - 1103-9345. ; :12 Augusti 2012
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 38. |
- Liimatainen, Tuire, et al.
(författare)
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”Kyss mig, jag är en sverigefinne!” : Gränsdragningar mellan invandrarskap och minoritetsskap i den sverigefinska etnopolitiska mobiliseringen 1980–2020
- 2021
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Ingår i: Tidskrift för Genusvetenskap. - : Tidskrift för genusvetenskap. - 1654-5443 .- 2001-1377. ; 42:4, s. 76-99
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Tidskriftsartikel (refereegranskat)abstract
- Unlike immigrants, national minorities are awarded recognition based on their long historical presence in the nation-state. While the political boundary between national minorities and immigrants is governed on state level, minorities’ own agency is significant for constructing and contesting ethnic and political boundaries. This article shows how Sweden-Finns, recognized as a national minority in Sweden since 2000, have contested the immigrant/national minority dichotomy in their transition from stigmatized post-war migranthood to recognized national minority-ness. By asking how boundary-making between migranthood and minority-ness is expressed in Sweden-Finnish ethnopolitical campaigns from the 1980s to the 2010s, we bring attention to how shifts in the socio-political and media technological contexts of these decades have shaped their mobilization. Through an analysis of newspaper articles, campaign material, and interviews, we show how Sweden-Finnish ethnic activists discursively construct identity and draw boundaries of belonging during different time periods.
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| 39. |
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| 40. |
- Lindell, Nina, et al.
(författare)
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Maternal obesity as a risk factor for early childhood type 1 diabetes : a nationwide, prospective, population-based case-control study
- 2018
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 61:1, s. 130-137
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Tidskriftsartikel (refereegranskat)abstract
- AIMS/HYPOTHESIS: Genetic and environmental factors are believed to cause type 1 diabetes. The aim of this study was to investigate the influence of maternal BMI and gestational weight gain on the subsequent risk of childhood type 1 diabetes.METHODS: Children in the Swedish National Quality Register for Diabetes in Children were matched with control children from the Swedish Medical Birth Register. Children were included whose mothers had data available on BMI in early pregnancy and gestational weight gain, giving a total of 16,179 individuals: 3231 children with type 1 diabetes and 12,948 control children.RESULTS: Mothers of children with type 1 diabetes were more likely to be obese (9% [n = 292/3231] vs 7.7% [n = 991/12,948]; p = 0.02) and/or have diabetes themselves (2.8% [n = 90/3231] vs 0.8% [n = 108/12,948]; p < 0.001) compared with mothers of control children. Gestational weight gain did not differ significantly between the two groups of mothers. In mothers without diabetes, maternal obesity was a significant risk factor for type 1 diabetes in the offspring (p = 0.04). A child had an increased risk of developing type 1 diabetes if the mother had been obese in early pregnancy (crude OR 1.20; 95% CI 1.05, 1.38; adjusted OR 1.18; 95% CI 1.02, 1.36). Among children with type 1 diabetes (n = 3231) there was a difference (p < 0.001) in age at onset in relation to the mother's BMI. Among children in the oldest age group (15-19 years), there were more mothers who had been underweight during pregnancy, while in the youngest age group (0-4 years) the pattern was reversed.CONCLUSIONS/INTERPRETATION: Maternal obesity, in the absence of maternal diabetes, is a risk factor for type 1 diabetes in the offspring, and influences the age of onset of type 1 diabetes. This emphasises the importance of a normal maternal BMI to potentially decrease the incidence of type 1 diabetes.
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| 41. |
- Lindell, Nina, 1984-
(författare)
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Perinatal risk factors for type 1 diabetes in children and adolescents
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive loss of the insulin producing pancreatic β-cells. The disease process starts years before the clinical diagnosis. The cause of T1D is unknown, but it is believed to be a combination of genetic and environmental factors. Around 50% of the genetic risk is attributed to the human leucocyte antigen (HLA) genes and the strongest associations are with the HLA-DR3-DQ2 and HLA-DR4-DQ8 haplotypes. The highest risk genotype is the heterozygote form of the two, the HLA-DQ2/8 genotype. It may be that certain environmental factors pose a risk to individuals with a particular genetic susceptibility but not to others. In the last few decades T1D incidence has risen very quickly and due to the rate of the increase, it is believed to depend on environmental factors rather than genetic. In parallel with this increase, the incidence of several environmental factors has also risen i.e., the incidence of cesarean section (CS), overweight/obesity in the general population and birthweight. These environmental factors have been implicated as risk factors for T1D, but studies have had conflicting results.Objective The overall aim of this thesis was to increase knowledge regarding factors during pregnancy and the perinatal period that could increase or decrease the risk of T1D among children and adolescents. The environmental risk factors studied were mode of childbirth (study I), maternal BMI and gestational weight gain (GWG) (study II) and the child’s size for gestational age and birthweight (study III). In the last study the environmental risk factors were compared between children with different genetic risks of T1D.Material and methods The studies included in this thesis are population-based register studies, three case-control studies and one cohort study, using prospectively collected material from the Swedish medical birth registry (MBR) and the Swedish pediatric diabetes quality registry (SWEDIABKIDS), as well as information from the Swedish national cohort study Better Diabetes Diagnosis (BDD). The study population consists of children and adolescents (0–18/19 years) diagnosed with T1D Jan 2000-Oct 2012 and registered in SWEDIABKIDS (n=9,376). All children with T1D were matched with four control children from the MBR with the same year and day of birth, same sex, and born in the same region of Sweden (n=37,504). In study I, the entire study population was used but in study III twins were excluded (n=552). In study II, children for whom data on their mother’s BMI in early pregnancy and GWG were available were included (3,231 children with T1D and 12,948 control children). In study IV, children with T1D who also participated in the BDD study were included (4,533 children).Results and conclusions Maternal overweight and obesity were associated with an increased risk of T1D in the offspring but were not more common among children with high or low genetic risk. Maternal BMI was also inversely associated with the age at onset of T1D in children with HLADQ8/ X and/or HLA-DQ2/X. Neither GWG nor mode of childbirth had any obvious impact on the risk of developing T1D. Being born large for gestational age or with a birthweight ≥4000 g (macrosomia) was associated with an increased risk of T1D and being born small for gestational age or with a low birthweight (<2500 g) was associated with a decreased risk of T1D, irrespective of maternal BMI and diabetes. Comparing children with T1D and different HLA genotypes revealed a slight difference in birthweight between the genotype groups. Children with HLA-DQ2/8 were more often born with macrosomia compared to children with HLA-DQ8/X. Children without either HLA-DQ2 or HLADQ8 (HLA-DQX/X) were more often born with a low birthweight compared to those with HLADQ2/ 8 and HLA-DQ8/X. Size for gestational age did not differ between the genotype groups, and the effect of size for gestational age and birthweight on age at onset of T1D was ambiguous.The effects of the environmental risk factors identified in this thesis are generally weak and no clear conclusion on whether they are causative can be drawn. Yet since overweight/obesity and a high birthweight are common in the population, even a small increase in risk can result in many cases of T1D. Overweight/obesity and a high birthweight are also associated with other adverse health outcomes and they are, at least partly, modifiable. This motivates additional research regarding their involvement in T1D etiology as well as preventive actions against overweight and obesity in the population.
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| 42. |
- Lindell, Nina, 1984-, et al.
(författare)
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Size for gestational age affects the risk for type 1 diabetes in children and adolescents : a Swedish national case–control study
- 2021
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 64:5, s. 1113-1120
-
Tidskriftsartikel (refereegranskat)abstract
- Aim/hypothesis: Environmental factors are believed to contribute to the risk of developing type 1 diabetes. The aim of this study was to investigate how size for gestational age affects the risk of developing childhood type 1 diabetes. Methods: Using the Swedish paediatric diabetes quality register and the Swedish medical birth register, children with type 1 diabetes diagnosed between 2000 and 2012 (n = 9376) were matched with four control children (n = 37,504). Small for gestational age (SGA) and large for gestational age (LGA) were defined according to Swedish national standards. Data were initially analysed using Pearson’s χ2 and thereafter by single and multiple logistic regression models. Results: An equal proportion of children were born appropriate for gestational age, but children with type 1 diabetes were more often born LGA and less often born SGA than control children (4.7% vs 3.5% and 2.0% vs 2.6%, respectively, p < 0.001). In the multiple logistic regression analysis, being born LGA increased (adjusted OR 1.16 [95% CI 1.02, 1.32]) and SGA decreased (adjusted OR 0.76 [95% CI 0.63, 0.92]) the risk for type 1 diabetes, regardless of maternal BMI and diabetes. Conclusions/interpretation: Size for gestational age of Swedish children affects the risk of type 1 diabetes, with increased risk if the child is born LGA and decreased risk if the child is born SGA. Being born LGA is an independent risk factor for type 1 diabetes irrespective of maternal BMI and diabetes. Thus, reducing the risk for a child being born LGA might to some extent reduce the risk for type 1 diabetes. Graphical abstract: [Figure not available: see fulltext.].
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| 43. |
- Littbrand, Håkan, 1966-, et al.
(författare)
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Effect of a high-intensity functional exercise program on functional balance : preplanned subgroup analyses of a randomized controlled trial in residential care facilities
- 2011
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Ingår i: Journal of The American Geriatrics Society. - : John Wiley & Sons. - 0002-8614 .- 1532-5415. ; 59:7, s. 1274-1282
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate whether age, sex, depression, dementia disorder, nutritional status, or level of functional balance capacity influences the effect of a high-intensity functional weight-bearing exercise program on functional balance.DESIGN: Preplanned subgroup analyses of a randomized controlled trial.SETTING: Nine residential care facilities.PARTICIPANTS: One hundred ninety-one people aged 65 to 100 dependent in activities of daily living and with Mini-Mental State Examination scores of 10 or greater.INTERVENTION: A high-intensity functional weight-bearing exercise program or a control activity, each comprising 29 sessions over 3 months.MEASUREMENTS: Functional balance capacity was assessed blindly using the Berg Balance Scale (BBS) at baseline, 3 months, and 6 months. The BBS consists of 14 tasks, common in everyday life, such as standing up from sitting and, while standing, reaching forward or turning 360°. Interactions between allocation to activity group and each subgroup were evaluated according to the intention-to-treat principle.RESULTS: The subgroup analyses revealed no statistically significant interaction for age, sex, depression, dementia disorder, nutritional status, or level of functional balance capacity at 3 (P=.65,.65,.51,.78,.09,.67, respectively) or 6 (P=.69,.62,.20,.94,.48,.85, respectively) months. In addition, at 3 and 6 months there was no significant interaction for cognitive level (P=.28,.47, respectively) or number of depressive symptoms (P=.85,.49, respectively).CONCLUSION: Older age, female sex, depression, mild to moderate dementia syndrome, malnutrition, and severe physical impairment do not seem to have a negative effect on functional balance from a high-intensity functional weight-bearing exercise program. Consequently, people with these characteristics in residential care facilities should not be excluded from offers of rehabilitation including high-intensity exercises.
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| 44. |
- Ludvigsson, Johnny, et al.
(författare)
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GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
- 2012
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 366:5, s. 433-442
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.METHODS: We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels.RESULTS: The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences.CONCLUSIONS: Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period.
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| 45. |
- Malmström, Nina, et al.
(författare)
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"Womanhood," a shared experience of participating in a lifestyle intervention with a focus on integration and physical activity to promote health among pregnant women : perspectives from pregnant women, midwives, and cultural interpreter doulas
- 2022
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Ingår i: International Journal of Qualitative Studies on Health and Well-being. - Abingdon : Taylor & Francis. - 1748-2623 .- 1748-2631. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Migrating women, have an overall increased risk of adverse outcomes and poorer health during pregnancy and childbirth. In addition, they do not participate in planned antenatal care to the same extent as natives. These disparities among migrants and native pregnant women point to the need for interventions to improve equal health and care during pregnancy and childbirth. This study aimed to explore the experiences of participating in a lifestyle intervention, named “Dancing for birth,” focusing on integration and physical activity, from the perspectives of the participating pregnant women, midwives, and cultural interpreter doulas.Method: Qualitative interviews were conducted from March 2019 to December 2020, with ten women who participated in a lifestyle intervention in Sweden: four pregnant women, three midwives, and three cultural interpreter doulas. Thematic analysis was used to analyse the data.Results: The lifestyle intervention ”Dancing for birth” provided positive shared Health-promoting experiences among the participants with social inclusivness and a commitment to supporting each other. This seemed to encourage the sense of strength as a woman- a strengthboth for the individual woman and as a kind of women´s power.Conclusions: Interventions targeting physical activity, social inclusiveness, and health literacy are of utmost importance in promoting positive pregnancy experiences and equal healthcare during pregnancy. Further research is needed on how to implement antenatal education that includes all women in society. © 2022 The Author(s).
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| 46. |
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| 47. |
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| 48. |
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| 49. |
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| 50. |
- Olsson, P., et al.
(författare)
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Uptake, toxicity and radiation effects of the boron compounds DAAC-1 and DAC-1 in cultured human glioma cells
- 1998
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Ingår i: International Journal of Radiation Biology. - 0955-3002 .- 1362-3095. ; 73:1, s. 103-112
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To study the uptake, toxicity and radiation effects in vitro of a diol-amino acid-carborane (DAAC-1) and make comparisons with the previously studied diol-amine-carborane (DAC-1). MATERIALS AND METHODS: Toxicity and radiation effects were studied with clonogenic survival, uptake by measuring the cellular boron content and the subcellular distribution was investigated after organelle separation with centrifugation. The studied cell line was human glioma U343. RESULTS: DAAC-1 showed an accumulation of 1-1.5 times, compared with the culture medium, and was non-toxic up to 47 microg boron/ml. The accumulation of DAC-1 was about 90 times, but toxic effects were detectable already at the concentration 5 microg boron/ml. None of the compounds was localized in the cell nucleus. Following irradiation with thermal neutrons, DAC-1 was about 2.5 times more effective than DAAC-1 and about 4.9 times more effective than neutrons alone, at the survival level 0.2. The dose modifying factors, when compared with the neutron beam alone, were for both DAAC-1 and DAC-1 about 1.5 and about 5 when compared with 60Co-gamma-radiation. CONCLUSIONS: DAAC-1 was less toxic than DAC-1 but gave less accumulation of boron. Both substances gave significant boron-dependent cell inactivation when the test cells were exposed to thermal neutrons.
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