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1.	Brorsson, Sofia, et al. (författare) A new electronic grip force measurement device for hand evaluation 2013 Ingår i: Abstracts of the Annual European Congress of Rheumatology EULAR. June 12-15, 2013. Madrid, Spain. Konferensbidrag (refereegranskat)abstract Background: Hand grip force is a good indicator of general muscle strength and can also be used to predict multiple outcomes such as changes in activities of daily living (ADL), disability, mortality and general upper extremity strength. Hand grip force is often measured as the amount of static grip force a subject can produce when measured with a hydraulic dynamometer such as the Jamar or with an electronic device such as the Grippit. The Grippit device measures an average grip force, a peak grip force and force over a set time period. Grippit has shown good reliability for healthy subjects. Grippit, which was developed over 20 years ago in Gothenburg, Sweden is no longer manufactured. Therefore, the need for anewly developed and modernized measurement instrument for use in evaluating hand rehabilitation has arisen. Objectives: The aim of this study was to evaluate the test-retest reliability of the newly developed instrument GRIP-it and to describe and validate the relationship between grip force measurements from GRIP-it and the original Grippit device. Methods: Healthy controls (n=43) were included in the study. Two devices were used to evaluate grip force (Newton, N), (i) GRIP-it a newly developed device and (ii) Grippit. Both instruments were used to measure mean and maximal force over 10 seconds. Results: GRIP-it displayed a mean measurement error of -1.7 ± 0.5% and the corresponding error for Grippit was -1.6 ± 1.9%. All subjects completed the grip force tests and the results for three attempts for each hand. The test-retest reliability was excellent for both pieces of equipment, with ICCs ranging from 0.963 to 0.947 (CI 95% between 0.103 and 0.041) for GRIP-it and from 0.979 to 0.968 (CI 95% between 0.087 and 0.042) for Grippit. Relationships between Grippit and GRIP-itThere was a significant difference between the measured values derived from Grippit and GRIP-it for both the dominant hand (P < 0.001) and the non-dominant hand (P < 0.01). Grippit gives in general a higher grip force measurement than GRIP-it which is also indicated by the slope (β1) of the regression lines that deviates from 1. However, there were no substantial differences in the grip force when comparing the measurements for the dominant hand with the non-dominant hand for either Grippit (P = 0.071) or GRIP-it (P = 0.404). Based on these non-significant differences between hands and the fact that the model estimates for the intercept (β0) and the slope (β1) are contained within the confidence intervals of the model estimates for the opposite hand, a combined model was derived. The linear regression analysis, with grip force measurements for both hands included, gives: GRIP-it = 49.0 + 0.779 · Grippit. This explains 89.6% of the variance in grip force analyzed by GRIP-it (P < 0.001) see Figure 2. To enable an estimation of grip force measured by Grippit based on GRIP-it values a regression analysis with Grippit as dependent variable gives: Grippit = -18.1 + 1.15 · GRIP-it, which explains 89.6% of the variance in grip force analyzed by Grippit (P < 0.001).Conclusions: This study showed that GRIP-it has excellent test-retest reliability. Measurements of grip force with GRIP-it are strongly related to those from the original Grippit. The newly developed GRIP-it shows great potential for use in the assessment of hand function and the evaluation of hand rehabilitation.
2.	Carlsson, Magnus, et al. (författare) Peak hand-grip force predicts competitive performance in elite female cross-country skiers 2014 Konferensbidrag (refereegranskat)
3.	Carlsson, Sofia, et al. (författare) 'The situation and the uncertainty about the coming result scared me but interaction with the radiographers helped me through' : a qualitative study on patients' experiences of magnetic resonance imaging examinations 2013 Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 22:21-22, s. 3225-3234 Tidskriftsartikel (refereegranskat)abstract Aims and objectives: To describe patients' expectations before and experiences during a head-first magnetic resonance imaging scan.Background: Previous studies have reported that patients experience fear and anxiety leading to discomfort before, during and after magnetic resonance imaging scans. Frequent problems persist in producing high-quality images due to motion artefacts. These results imply a need for improvement of patient conditions to allow for the added benefit of better diagnostic quality. Provision of extended written information has not appeared to reduce patients' stress, while interaction with staff has been described as the most important factor for reducing such feelings.Design and methods: A qualitative, phenomenological approach. Semi-structured interviews were conducted, and data were analysed with systematic text condensation.Results: The experiences of the ten participants were encapsulated by the main theme: The situation and the uncertainty about the coming result scared me but interaction with the radiographers helped me through'. Subthemes were Prescan preparation', Mastering threats to self-control' and Personal achievements by completing the scan'.Conclusions: Our study has provided a deeper understanding of the expectations before, and experiences during, a head-first magnetic resonance imaging scan. Valuable insight into patients' apprehension about written and verbal information was obtained. The patients reported how they coped with the unfamiliar and stressful magnetic resonance imaging scanning procedure. A trustful dialogue with the radiographer was described as being crucial for patients' ability to manage fear, discomfort and feelings of loss of self-control. We suggest a need for individualised information based on patient participation.Relevance to clinical practice: Radiographers, as well as nurses caring for patients who will undergo magnetic resonance imaging examinations, should recognise the difficulties inherent in written information. It is also of importance to adjust the patient-radiographer interaction to address patients' expressions of worries about the scanning procedure or the following result.
4.	Hjort, Rebecka, et al. (författare) Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study 2015 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 58:11, s. 2525-2532 Tidskriftsartikel (refereegranskat)abstract Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing < 3 kg compared with >= 4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (< 3 kg) and current overweight (BMI >= 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes.
5.	Hjort, Rebecka, et al. (författare) Overweight, obesity and the risk of LADA : results from a Swedish case–control study and the Norwegian HUNT Study 2018 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 61:6, s. 1333-1343 Tidskriftsartikel (refereegranskat)abstract Aims/hypothesis: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case–control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984–2008). We present adjusted ORs and HRs with 95% CI. Results: In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA;
6.	Hjort, Rebecka, et al. (författare) Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes 2020 Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 105:11 Tidskriftsartikel (refereegranskat)abstract PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. METHODS: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3 times/week) self-reported leisure time PA, compared to sedentariness. RESULTS: High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype. MAIN CONCLUSIONS: Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility.
7.	Löfvenborg, Josefin E., et al. (författare) Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes 2016 Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 175:6, s. 605-614 Tidskriftsartikel (refereegranskat)abstract Objective: Sweetened beverage intake is associated with increased risk of type 2 diabetes, but its association with autoimmune diabetes is unclear. We aimed to investigate sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA); autoimmune diabetes with features of type 2 diabetes. Design/methods: Data from a Swedish population-based study was used, including incident cases of LADA (n = 357) and type 2 diabetes (n = 1136) and randomly selected controls (n = 1371). Diabetes classification was based on onset age (≥35), glutamic acid decarboxylase autoantibodies (GADA) and C-peptide. Sweetened beverage intake information was derived from a validated food frequency questionnaire. ORs adjusted for age, sex, family history of diabetes, education, lifestyle, diet, energy intake and BMI were estimated using logistic regression. Results: Daily intake of >2 servings of sweetened beverages (consumed by 6% of participants) was associated with increased risk of LADA (OR: 1.99, 95% CI: 1.11-3.56), and for each 200 mL daily serving, OR was 1.15 (95% CI: 1.02-1.29). Findings were similar for sugar-sweetened (OR: 1.18, 95% CI: 1.00-1.39) and artificially sweetened beverages (OR: 1.12, 95% CI: 0.95-1.32). Similarly, each daily serving increment in total sweetened beverage conferred 20% higher type 2 diabetes risk (95% CI: 1.07-1.34). In type 2 diabetes patients, high consumers displayed higher HOMA-IR levels (4.5 vs 3.5, P = 0.0002), but lower HOMA-B levels (55 vs 70, P = 0.0378) than non-consumers. Similar tendencies were seen in LADA. Conclusions: High intake of sweetened beverages was associated with increased risk of LADA. The observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance.
8.	Rasouli, Bahareh, et al. (författare) Alcohol and the risk for LADA: results based on the Swedish ESTRID study. 2014 Ingår i: European Journal of Endocrinology. - 1479-683X. ; 171:5, s. 535-543 Tidskriftsartikel (refereegranskat)abstract Objective Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. Our aim was to investigate whether alcohol consumption is associated with risk of latent autoimmune diabetes in adults (LADA), an autoimmune form of diabetes with features of type 2 diabetes. Design Population-based case-control study Methods We used data from ESTRID case-control study carried out between 2010 and 2013, including 250 incident cases of LADA (glutamic acid decarboxylase antibodies [GADA] positive) and 764 cases of type 2 diabetes (GADA negative), and 1012 randomly selected controls aged ≥35. Logistic regression was used to estimate the odds ratios (OR) of diabetes in relation to alcohol intake, adjusted for age, sex, BMI, family history of diabetes, smoking, and education. Results Alcohol consumption was inversely associated with the risk of type 2 diabetes (OR 0.95, 95% confidence interval (CI); 0.92-0.99 for every 5-g increment in daily intake). Similar results were seen for LADA, but stratification by median GADA levels revealed that the results only pertained to LADA with low GADA (OR 0.85; 95% 0.76-0.94 per 5g alcohol/day), whereas no association was seen with LADA high GADA (OR 1.00, 95% CI; 0.94-1.06 per 5g/day). Every 5-g increment of daily alcohol intake was associated with a 10% increase in GADA levels (p=0.0312), and a10% reduction in HOMA-IR (p=0.0418). Conclusions Our findings indicate that alcohol intake may reduce risk of type 2 diabetes and type 2-like LADA, but has no beneficial effects on diabetes-related autoimmunity.
9.	Rasouli, Bahareh, et al. (författare) Alcohol and the risk for latent autoimmune diabetes in adults : results based on Swedish ESTRID study 2014 Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 171:5, s. 535-543 Tidskriftsartikel (refereegranskat)abstract Objective: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. Our aim was to investigate whether alcohol consumption is associated with the risk of latent autoimmune diabetes in adults (LADA), an autoimmune form of diabetes with features of type 2 diabetes. Design: A population-based case-control study was carried out to investigate the association of alcohol consumption and the risk of LADA. Methods: We used data from the ESTRID case-control study carried out between 2010 and 2013, including 250 incident cases of LADA (glutamic acid decarboxylase antibodies (GADAs) positive) and 764 cases of type 2 diabetes (GADA negative), and 1012 randomly selected controls aged >= 35. Logistic regression was used to estimate the odds ratios (ORs) of diabetes in relation to alcohol intake, adjusted for age, sex, BMI, family history of diabetes, smoking, and education. Results: Alcohol consumption was inversely associated with the risk of type 2 diabetes (OR 0.95, 95% CI 0.92-0.99 for every 5-g increment in daily intake). Similar results were observed for LADA, but stratification by median GADA levels revealed that the results only pertained to LADA with low GADA levels (OR 0.85, 95% CI 0.76-0.94/5 g alcohol per day), whereas no association was observed with LADA having high GADA levels (OR 1.00, 95% CI 0.94-1.06/5 g per day). Every 5-g increment of daily alcohol intake was associated with a 10% increase in GADA levels (P=0.0312), and a 10% reduction in homeostasis model assessment of insulin resistance (P=0.0418). Conclusions: Our findings indicate that alcohol intake may reduce the risk of type 2 diabetes and type 2-like LADA, but has no beneficial effects on diabetes-related autoimmunity.
10.	Rasouli, Bahareh, et al. (författare) Smoking and the risk of LADA : Results from a Swedish population-based case-control study 2016 Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 39:5, s. 794-800 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: Smoking is an established risk factor for type 2 diabetes. In contrast, it has been proposed that smoking may reduce the risk of latent autoimmune diabetes in adults (LADA), but studies are scarce. We aimed to study the impact of smoking on LADA and type 2 diabetes risks. RESEARCH DESIGN AND METHODS: We used data from a Swedish case-control study including incident case patients with LADA (GAD antibody [GADA] positive, n = 377) and type 2 diabetes (GADA negative, n = 1,188) and control subjects randomly selected from the population (n = 1,472). We calculated odds ratios (ORs) with 95% CIs by logistic regression, adjusted for age, sex, BMI, family history of diabetes, and alcohol consumption. RESULTS: There was no indication of reduced risk of LADA in smokers; instead, heavy smoking was associated with an increased risk of LADA (OR 1.37, 95% CI 1.02-1.84). Heavy smokers had higher levels of HOMA of insulin resistance (9.89 vs. 4.38, P = 0.0479) and HOMA of β-cell function (55.7 vs. 42.5, P = 0.0204), but lower levels of GADA (75 vs. 250, P = 0.0445), compared with never smokers. Smokers also displayedanincreased risk oftype2 diabetes (OR in eversmokers 1.53, 95% CI 1.25-1.88). CONCLUSIONS: In this large population of LADA patients, we did not observe a protective effect of smoking on autoimmunity and the risk of LADA. A protective effect could possibly be masked by a smoking-induced aggravation of insulin resistance, akin to the diabetogenic effect seen in individuals with type 2 diabetes.
11.	Andell, Eva, et al. (författare) The incidence of unprovoked seizures and occurrence of neurodevelopmental comorbidities in children at the time of their first epileptic seizure and during the subsequent six months 2015 Ingår i: Epilepsy Research. - : Elsevier BV. - 0920-1211 .- 1872-6844. ; 113, s. 140-150 Tidskriftsartikel (refereegranskat)abstract Purpose: To evaluate the incidence of unprovoked seizures in children and the prevalence of related neurodevelopmental comorbidities at the time of the presumed first seizure and six months thereafter. Methods: The medical records of all children (0-18 years of age) seeking medical attention as the result of a first unprovoked seizure between September 1, 2001 and December 31, 2006, and registered in the population-based Stockholm Incidence Registry of Epilepsy (SIRE) were reviewed. Neurodevelopmental comorbidities were evaluated on the basis of the medical records from this first visit and from other healthcare during the following six months. Results: The incidence of unprovoked seizures was between 30 and 204/100,000 person years (n=766) in the different age groups. It was highest among the youngest children and lowest among the 18-year-olds with small gender differences. The most common neurodevelopment comorbidities were developmental delay (22%, CI: 19-25%), speech/language and learning difficulties (23%, CI: 20-26%) and intellectual disability (16%, CI: 13-18%). The types of neurodevelopmental comorbidity varied by age at the time of seizure onset, with cerebral palsy being more common among the 0-5-year-olds, attention deficits among the 6-16-year-olds, and autism and psychiatric diagnosis among the older children. An associated neurodevelopmental comorbidity was more common among those experiencing recurrent than single seizures during follow-up six months from the index seizure (42% versus 66%). In 68% (CI: 64-71%) of the children there was no known or suspected neurodevelopmental comorbidity. Conclusion: The incidence of unprovoked, non-febrile seizures among 0-18-year-olds included in the SIRE was 67/100,000 person-years. Neurodevelopmental comorbidities were common already at the time of onset of the seizure disorder, indicating that neither seizure treatment nor seizures were the underlying cause of other neurodevelopmental symptoms in these patients during the period studied.
12.	Areias, Filipe, et al. (författare) 2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists : The 6-Morpholino Derivatives 2024 Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 29:11 Tidskriftsartikel (refereegranskat)abstract A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A1, A2A, A2B, and A3 adenosine receptor subtypes. Eleven purines showed potent antagonism at A1, A3, dual A1/A2A, A1/A2B, or A1/A3 adenosine receptors. Additionally, three compounds showed high affinity without selectivity for any specific adenosine receptor. The structure-activity relationships were made for this group of new compounds. The 9-methylpurine derivatives were generally less potent but more selective, and the 9H-purine derivatives were more potent but less selective. These compounds can be an important source of new biochemical tools and/or pharmacological drugs.
13.	Axelsson, Roger, 1967-, et al. (författare) Sveriges historia för släktforskare 2022 Bok (populärvet., debatt m.m.)
14.	Bastviken, Sofia, et al. (författare) Läget i länet? Tillståndet i Östergötlands vattenmiljöer 2011 Rapport (övrigt vetenskapligt/konstnärligt)abstract Östergötland finns många varierande och värdefulla vattenmiljöer. Mer än hälften av länets vattenmiljöer har dock inte tillräckligt bra vattenkvalitet för att nå upp till de mål som antagits inom Sverige och EU. Länets vatten har under lång tid varit utsatt för olika typer av miljöpåverkan från mänskliga verksamheter. I många fall leder det till miljöproblem som algblomningar eller förstörda livsmiljöer.Flera åtgärder genomförs nu för att för att förbättra miljötillståndet i länets vatten. De största hoten mot Östergötlands vattenmiljöer är övergödning, utsläpp av miljögifter och fysisk påverkan i form av t.ex. dikning, dämning och omledning av vatten. Andra mindre omfattande problem är försurning och införsel av främmande arter som ibland tränger undan våra inhemska arter.Övergödning är främst ett problem i sjöar och vattendrag på östgötaslättensamt i kustvattnet. Läckage från jordbruksmark, utsläpp av avloppsvatten och förbränning av fossila bränslen är några av de källor som tillför näringsämnen till vattenmiljön. För mycket näring leder bland annat till algblomningar, grumling och syrefria bottnar.Från syrefria bottnar läcker i sin tur fosfor till ovanliggande vatten och det krävs därför kraftiga åtgärdsinsatser för att vända en negativ spiral. Många åtgärder genomförs för att minska utsläpp av näringsämnen, och utsläpp från industri och reningsverk har minskat markant. Än så länge kan vi dock inte utifrån våra miljödata se några tydliga förbättringar i miljötillståndet. Detta beror på att det efter decennier av utsläpp finns stora mängder näringsämnen upplagrade i mark och bottensediment. De ”gamla synderna” medför att det tar tid innan vi ser resultat av de åtgärder som hittills genomförts.De senaste tio åren har dessutom varit blötare än tidigare och under nederbördsrika år läcker generellt mer näringsämnen från mark till vatten. Länsstyrelsen arbetar tillsammans med kommuner, vattenråd och andra berörda parter inom länet för att förbättra miljötillståndet.Takten på åtgärdsarbetet har ökat under senare år och förhoppningsvis återspeglar det sig snart i våra mätdata. Mycket har också hänt på miljögiftsområdet och halterna av flera miljögifter har minskat under senare år. Men faran är inte över, hela tiden framställs nya kemikalier som förr eller senare hamnar i vattenmiljön. Genom så kallade screeningundersökningar försöker Länsstyrelsen hitta nya ämnen som kan hota miljön och människors hälsa. Nya regelverk inom EU gör det också enklare att få kontroll på kemikalier samt att minska utsläppen. Många av de ämnen och produkter som vi använder i vår vardag återfinns i miljön, till exempel bisfenol A och nonylfenol. Länsstyrelsen och kommunerna arbetar också för att minska spridning av föroreningar från redan förorenade mark- och vattenområden som till exempel i Gusum och Valdemarsviken. Ett kvarstående problem, i såväl Östergötland som övriga Sverige, är också det höga kvicksilverinnehållet i sötvattenslevande fisk. För att öka kunskaperna om förekomst och spridning av miljögifter i länet har Länsstyrelsen och Motala ströms vattenvårdsförbund utökat övervakningen av miljögifter.Ett annat utbrett miljöproblem i länets sjöar och vattendrag är olika former av fysiska förändringar. Människan har under lång tid utnyttjat vattnet för olika ändamål, ofta utan hänsyn till växt- och djurliv. Flera sjöar har torrlagts eller sänkts för att kunna bruka marker som översvämmats eller varit försumpade. Nästan alla större vattendrag i länet är idag utbyggda med vattenkraftverk och regleringsmagasin.Ingreppen har förändrat vattnets naturliga väg och flöde, och dammar utgör dessutom ofta vandringhinder för t.ex. fisk. I länet pågår nu flera projekt för att åtgärda vandringshinder och återställa rensade vattendrag till mer naturliga förhållanden, med bättre förutsättningar för fisk och andra organismer.Ett mindre utbrett problem i länets sjöar och vattendrag är försurning. Tack vare att stora områden i länet består av kalkhaltiga jordar som buffrar surt nedfall har vi inte lika stora problem med försurning som många andra län. Problem med försurning är störst i länets norra och södra skogsbygder. Orsaker till försurningen är utsläpp från transporter, energianläggningar, industri och jordbruk.Utsläppen av svavel och kväve har minskat kraftigt under de senaste tio åren, men återhämtningen tar tid och flera vatten måste därför kalkas under en lång tid framöver.I länets vattenmiljöer finns flera främmande arter som kommit hit med människans hjälp. De allra flesta arter är harmlösa, medan vissa tränger undan våra inhemska arter och därmed minskar den biologiska mångfalden. En art som ställt till med stora problem i länets vatten är signalkräftan. Signalkräftan sprider kräftpest till vår inhemska flodkräfta och flodkräftan är nu akut hotad. Den låga salthalten gör att Östersjöns ekosystem är extra känslig för påverkan i och med att flera av de arter som lever här lever nära eller på gränsen av vad de klarar av. De är mer eller mindre stressade av salthalten och är därför ofta känsligare än när de förekommer i sin ursprungsmiljö. Ökad konkurrens från främmande arter kan bidra till att de ursprungliga arterna får svårare att överleva. Under senare år har två främmande arter, havsborstmasken Marenzelleria och tusensnäckan Potamopyrgus antipodarum blivit allt vanligare på bottnarna i östgötaskärgården. Dessa arter är särskilt vanliga i länets innerskärgårdar och det finns risk att de tränger ut inhemska bottendjur.Eftersom havsborstmasken Marenzelleria kan gräva mycket djupa gångar i bottnarna kan de bidra till ökad frisättning av miljögifter och näringsämnen som länge legat begravda i sedimenten. Tillgången på grundvatten är generellt god i länet, men olika former av mänsklig påverkan riskerar att förorena grundvattnet. Övervakningen av grundvattenmagasin är relativt nystartad och vi vet ännu relativt lite om grundvattnets kvalitet. De undersökningar som Länsstyrelsen hittills genomfört har visat spår av både organiska föroreningar och tungmetaller i några av länets grundvattenmagasin.En del av de problem som finns i grundvattnet, som till exempel höga halter av radon, fluorid och uran, kan dock kopplas till naturliga förekomster i berggrunden. Överuttag av grundvatten i kust och skärgårdsområden kan leda till saltvatteninträngning. Eftersom större delen av Östergötland har varit täckt av hav kan grundvattnet även vara påverkat av relikt (gammalt) saltvatten.Den här rapporten är en del i Länsstyrelsens satsning för att öka kunskapen och medvetenheten om länets vattenmiljöer. Tillsammans kan vi verka för att vårda, bevara och förbättra miljötillståndet i våra unika vattenmiljöer.Det pågår ett intensivt förbättringsarbete på flera nivåer, såväl internationellt som nationellt. På den lokala nivån finns ett stort intresse och engagemang inom länets nio lokala samverkansforum, de s.k. vattenråden.Det har aldrig funnits så stor chans att påverka vattenmiljön som nu!
15.	Bengtsson, Simon, et al. (författare) Effektiv luftning : Design, drift, underhåll och upphandling av luftningsutrustning för kommunala avloppsre-ningsverk 2019 Rapport (övrigt vetenskapligt/konstnärligt)abstract Rapporten beskriver luftning vid kommunala avloppsreningsverk med fokus på energieffektivitet. Den tar upp design av luftningsanläggningar samt lämpliga metoder för styrning, drift, uppföljning och underhåll − med exempel från verkligheten och modellsimuleringar. Rapporten ger också vägledning för upphandling av luftningsanläggningen.
16.	Bentham, James, et al. (författare) A century of trends in adult human height 2016 Ingår i: eLIFE. - 2050-084X. ; 5 Tidskriftsartikel (refereegranskat)abstract Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
17.	Bentham, James, et al. (författare) A century of trends in adult human height 2016 Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5 Tidskriftsartikel (refereegranskat)abstract Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
18.	Bertmar, Sofia, et al. (författare) Who's Most Targeted and Does My New Adblocker Really Help : A Profile-based Evaluation of Personalized Advertising 2021 Ingår i: Proc. ACM CCS Workshop on Privacy in the Electronic Society (ACM WPES @CCS). - New York, NY, USA : ACM Digital Library. - 9781450385275 Konferensbidrag (refereegranskat)abstract There is limited prior work studying how the ad personalization experienced by different users is impacted by the use of adblockers, geographic location, the user's persona, or what browser they use. To address this void, this paper presents a novel profile-based evaluation of the personalization experienced by carefully crafted user profiles. Our evaluation framework impersonates different users and captures how the personalization changes over time, how it changes when adding or removing an extension, and perhaps most importantly how the results differ depending on the profile's persona (e.g., interest, occupation, age, gender), geographic location (US East, US West, UK), what browser extension they use (none, AdBlock, AdBlock Plus, Ghostery, CatBlock), what browser they use (Chrome, Firefox), and whether they are logged in to their Google account. By comparing and contrasting observed differences we provide insights that help explain why some user groups may feel more targeted than others and why some people may feel even more targeted after having turned on their adblocker.
19.	Bredberg, Johanna, et al. (författare) Likabehandling på pappret?. En kritisk granskning av litteraturen på juristprogrammet 2011 Rapport (övrigt vetenskapligt/konstnärligt)
20.	Carlsson, Anna-Sofia (författare) Kartläggning och utvärdering av plaståtervinning i ett systemperspektiv 2002 Rapport (övrigt vetenskapligt/konstnärligt)abstract Syftet med studien har varit att kartlägga materialåtervinningen av förpackningsplast i Sverige idag och utvärdera en redan befintlig systemanalytisk avfallshanteringsmodell (ORWARE), samt att utföra en systemanalys på plaståtervinning med modellen som verktyg. Tre scenarier har studerats i analysen - energiutvinning, materialåtervinning med antagandet att återvunnen plast ersätter jungfrulig plast fullt ut i förhållandet 1:1, samt materialåtervinning med ett mera verklighetsbaserat antagande om vad den återvunna plasten ersätter och i vilket förhållande. Enligt kartläggningen av materialåtervinning av plast i Sverige idag visade sig cirka 20 % av den återvunna hårdplasten ersätta tryckimpregnerat trä istället för jungfrulig plast. Dessutom visade det sig att den återvunna mjukplasten ibland kunde vara av något sämre kvalitet än jungfrulig plast. Återvunnen mjukplast antogs därför ersätta jungfrulig plast i förhållandet 1:0,7. Dessa båda antaganden ligger till grund för det mera verklighetsbaserade scenariot. Resultaten har utvärderats med livscykelanalysmetodik där följande parametrar har studerats: total energianvändning, växthuseffekt, försurning, övergödning, fotooxidanter - NOx och VOC. Resultaten visar att materialåtervinning av förpackningsplast medför en miljövinst i samtliga studerade miljöpåverkanskategorier jämfört med energiutvinning, även om man gör antaganden som beskriver ett mera verklighetstroget scenario. Detta gäller under förutsättningen att den uteblivna fjärrvärmen från energiutvinningen ersätts med fjärrvärme från biobränsle. En känslighetsanalys på ersättningsbränsle för fjärrvärme visar att om kol antas användas istället för biobränsle, är energiutvinning mera fördelaktigt än materialåtervinning med avseende på samtliga studerade miljöpåverkanskategorier förutom fotooxiderande VOC.
21.	Carlsson, Eric, 1972-, et al. (författare) Teknografi 2021 Ingår i: Digitala metoder i humaniora och samhällsvetenskap. - Lund : Studentlitteratur AB. - 9789144140551 ; , s. 45-69 Bokkapitel (refereegranskat)abstract Teknografiska studier undersöker förhållandet mellan teknik, kultur och sociala relationer. Ett sådant perspektiv kan användas för att synliggöra hur teknologier villkorar hur människor agerar, hur deras identiteter formas och hur de blir till som subjekt. I kapitlet exemplifieras hur olika material, såsom digitala vårdappar, innehåll från sociala medier samt intervjuer, kan användas i teknografiskt inspirerade kvalitativa analyser.
22.	Carlsson, Jenny Rubensdotter, et al. (författare) Drug experts of the future, today? : Depiction of the pharmacist profession in Swedish professional and lay print media 2012 Ingår i: Research in Social and Administrative Pharmacy. - : Elsevier BV. - 1551-7411 .- 1934-8150. ; 8:2, s. 133-144 Tidskriftsartikel (refereegranskat)abstract Background: The Swedish pharmacy market is presently being reregulated. The state-owned pharmacy monopoly company was divided and sold during 2009, and certain nonprescription medicines are now allowed in nonpharmacy settings. The changes will likely affect the pharmacist's role and the image of the community pharmacist in society. This change may affect how pharmacists are seen by society at large, and therefore, a baseline showing how pharmacists are depicted before the reregulation is of great value. Objectives: The aim of this study was to describe how the pharmacist profession is depicted in print media in Sweden, with a focus on community pharmacy. Methods: A deductive qualitative content analysis with material from print media was conducted, using professional criteria as a framework. Swedish print media from October 2005 to October 2008 were searched and all relevant articles included. Results: A total of 139 articles were included. Most articles came from professional journals, that is, journals directed toward pharmacist or related professions. The results show that the pharmacist profession is not highly visible and that this lack of visibility is disappointing to pharmacists. Conclusions: Society, as reflected in print media, does not display an awareness of the pharmacist role in Sweden. Although this is disappointing for the profession, it allows pharmacists to influence the depiction and hence their position in society.
23.	Carlsson, Julia Sofia, et al. (författare) Digitaliserat ekonomiskt bistånd – Konstruktioner av ”nya” relationer inom socialtjänsten 2021 Rapport (övrigt vetenskapligt/konstnärligt)abstract Denna rapport syftar till att belysa om, och i så fall hur, klienters tillgång till välfärdsservice förändras vid användningen av digitala verktyg inom socialtjänsten. Forskningsfrågan som guidar studien är: hur påverkas relationen mellan socialsekreterare och klient av införandet av digitala verktyg inom ekonomiskt bistånd?I studien undersöks socialsekreterares uppfattningar om sin relation till klienter i tre olika kommuner. Genom ett urval av tre kommuner som kommit olika långt i sitt digitaliseringsarbete öppnar studien upp för en jämförelse mellan socialsekreterarnas beskrivningar. I jämförelsen uppmärksammas skillnader mellan beskrivningar av relationen mellan socialsekreterare och klient. Genom att studera skillnader synliggörs om, och i så fall hur, digitala verktyg har en inverkan på relationen mellan socialsekreterare och klient.Valet att ställa relationen i fokus i studien grundar sig på att tidigare forskning pekar på att relationen mellan ”det offentliga” och invånare är central för invånares tillgång till välfärdsservice och förutsättning för offentligt stöd. I förlängningen blir därigenom studien en grund för att diskutera om och hur klienters tillgång till ekonomiskt bistånd förändras vid introduktionen av digitala verktyg och huruvida det finns en risk för ett digitalt utanförskap.Resultatet från studien visar att den arbetsdelning som följer av en digitalisering kan påverka till en ökad distans mellan socialsekreterare och klientklienter och att det med digitalisering följer en retorik som handlar om att mer ansvar bör läggas på enskilda medborgare. Det kan för den enskilda klienten leda till ett ökat ansvar över att driva det egna ärendet i relation till myndigheten och därigenom försämra klienters tillgång till välfärdsservice för klienter. Dock behöver inte så vara fallet. Studiens resultat visar samtidigt att socialsekreterare och ekonomisekreterare till stor del betraktar de digitala verktygen som ett komplement, som breddar tillgängligheten och att medvetenheten om risker för ett digitalt utanförskap ger en lyhördhet inför om klienter har behov av stöd. Med andra ord visar studien hur socialsekreterare och/eller ekonomisekreterare arbetar för att kompensera för teknikens brister.
24.	Carlsson, Julia Sofia (författare) Exploring the many tales behind success : understanding translations of the “intrapreneurships” management fashion as editing processes 2021 Ingår i: Qualitative research in organization and management. - : Emerald Group Holdings Ltd.. - 1746-5648 .- 1746-5656. Tidskriftsartikel (refereegranskat)abstract Purpose: The paper explores a management fashion within the Swedish Public Sector called intrapreneurships. Intrapreneurships became popular during a period of public debate on what forms of organizing are most suitable for the production of welfare. However, while the popularity of the model was short-lived, a few municipalities nevertheless constitute examples of where it was supported for a longer period. The aim of this paper is to investigate how the model became continuously legitimate having lost its appeal elsewhere.Design/methodology/approach: The paper comprises a longitudinal analysis of two municipalities. Field-material was collected through qualitative methods including interviews (35 interviews, 42 interviewees) and document analysis.Findings: The results draw attention to how management fashions become enduring. The metaphor of translation highlights how different professional actors in a local setting apply editing rules, and how they constitute work acquired for continuous translation of the model in order to make it legitimate, disseminated and supported. The study draws particular attention to the large number of actors involved in the editing process.Originality/value: Besides an extended understanding of management concepts, to explain the anomaly of a long-standing management fashion, the paper illustrates the importance of acknowledging editing as processes and not process. A key notion in why intrapreneurships became legitimate is that professional actors edited the model differently in order to satisfy their desires and needs. This contradicts the more common case study design in translation studies, which seeks a unitary translation process, in a single local setting. © 2021, Julia Sofia Carlsson.
25.	Carlsson, Johan, 1987, et al. (författare) The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro : AA and DHA Induce DCs That Suppress T Cells 2015 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:11 Tidskriftsartikel (refereegranskat)abstract Long-chain polyunsaturated fatty acids (PUFAs) might regulate T-cell activation and lineage commitment. Here, we measured the effects of omega-3 (n-3), n-6 and n-9 fatty acids on the interaction between dendritic cells (DCs) and naive T cells. Spleen DCs from BALB/c mice were cultured in vitro with ovalbumin (OVA) with 50 muM fatty acids; alpha-linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linoleic acid or oleic acid and thereafter OVA-specific DO11.10 T cells were added to the cultures. Fatty acids were taken up by the DCs, as shown by gas chromatography analysis. After culture with arachidonic acid or DHA CD11c+ CD11b+ and CD11c+ CD11bneg DCs expressed more CD40, CD80, CD83, CD86 and PDL-1, while IAd remained unchanged. However, fewer T cells co-cultured with these DCs proliferated (CellTrace Violetlow) and expressed CD69 or CD25, while more were necrotic (7AAD+). We noted an increased proportion of T cells with a regulatory T cell (Treg) phenotype, i.e., when gating on CD4+ FoxP3+ CTLA-4+, CD4+ FoxP3+ Helios+ or CD4+ FoxP3+ PD-1+, in co-cultures with arachidonic acid- or DHA-primed DCs relative to control cultures. The proportion of putative Tregs was inversely correlated to T-cell proliferation, indicating a suppressive function of these cells. With arachidonic acid DCs produced higher levels of prostaglandin E2 while T cells produced lower amounts of IL-10 and IFNgamma. In conclusion arachidonic acid and DHA induced up-regulation of activation markers on DCs. However arachidonic acid- and DHA-primed DCs reduced T-cell proliferation and increased the proportion of T cells expressing FoxP3, indicating that these fatty acids can promote induction of regulatory T cells.
26.	Carlsson, Johan, 1987, et al. (författare) The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro 2015 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 10:11, s. e0143741- Tidskriftsartikel (refereegranskat)abstract Long-chain polyunsaturated fatty acids (PUFAs) might regulate T-cell activation and lineage commitment. Here, we measured the effects of omega-3 (n-3), n-6 and n-9 fatty acids on the interaction between dendritic cells (DCs) and naive T cells. Spleen DCs from BALB/c mice were cultured in vitro with ovalbumin (OVA) with 50 muM fatty acids; alpha-linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linoleic acid or oleic acid and thereafter OVA-specific DO11.10 T cells were added to the cultures. Fatty acids were taken up by the DCs, as shown by gas chromatography analysis. After culture with arachidonic acid or DHA CD11c+ CD11b+ and CD11c+ CD11bneg DCs expressed more CD40, CD80, CD83, CD86 and PDL-1, while IAd remained unchanged. However, fewer T cells co-cultured with these DCs proliferated (CellTrace Violetlow) and expressed CD69 or CD25, while more were necrotic (7AAD+). We noted an increased proportion of T cells with a regulatory T cell (Treg) phenotype, i.e., when gating on CD4+ FoxP3+ CTLA-4+, CD4+ FoxP3+ Helios+ or CD4+ FoxP3+ PD-1+, in co-cultures with arachidonic acid- or DHA-primed DCs relative to control cultures. The proportion of putative Tregs was inversely correlated to T-cell proliferation, indicating a suppressive function of these cells. With arachidonic acid DCs produced higher levels of prostaglandin E2 while T cells produced lower amounts of IL-10 and IFNgamma. In conclusion arachidonic acid and DHA induced up-regulation of activation markers on DCs. However arachidonic acid- and DHA-primed DCs reduced T-cell proliferation and increased the proportion of T cells expressing FoxP3, indicating that these fatty acids can promote induction of regulatory T cells.
27.	Carlsson, Ninni, 1962, et al. (författare) ”Visa i handling vad arbetet mot mäns våld är värt” 2019 Ingår i: Svenska Dagbladet. ; 2019:4 april Tidskriftsartikel (populärvet., debatt m.m.)abstract Mitt i debatten om Josefin Nilsson och det våld mot henne som närstående berättar om i SVT-dokumentären ”Älska mig för den jag är”, tillkännager regeringen, C och L att de föreslår 45 miljoner i vårbudget för att bekämpa mäns våld mot kvinnor. Flera medier kallar det en storsatsning men är det verkligen det, frågar våldsforskare, #metoo-upprop och organisationer. Med hjälp av aktuell forskning argumenterar de för att detta är långt ifrån tillräckligt, kräver större vårbudget mot mäns våld mot kvinnor och bjuder in riksdag och regering till dialog.
28.	Carlsson, Per-Ola, et al. (författare) Umbilical cord-derived mesenchymal stromal cells preserve endogenous insulin production in type 1 diabetes : a Phase I/II randomised double-blind placebo-controlled trial 2023 Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 66:8, s. 1431-1441 Tidskriftsartikel (refereegranskat)abstract Aim/hypothesis This study aimed to investigate the safety and efficacy of treatment with allogeneic Wharton's jelly-derived mesenchymal stromal cells (MSCs) in recent-onset type 1 diabetes.Methods A combined Phase I/II trial, composed of a dose escalation followed by a randomised double-blind placebo-controlled study in parallel design, was performed in which treatment with allogeneic MSCs produced as an advanced therapy medicinal product (ProTrans) was compared with placebo in adults with newly diagnosed type 1 diabetes. Inclusion criteria were a diagnosis of type 1 diabetes <2 years before enrolment, age 18-40 years and a fasting plasma C-peptide concentration >0.12 nmol/l. Randomisation was performed with a web-based randomisation system, with a randomisation code created prior to the start of the study. The randomisation was made in blocks, with participants randomised to ProTrans or placebo treatment. Randomisation envelopes were kept at the clinic in a locked room, with study staff opening the envelopes at the baseline visits. All participants and study personnel were blinded to group assignment. The study was conducted at Karolinska University Hospital, Stockholm, Sweden.Results Three participants were included in each dose cohort during the first part of the study. Fifteen participants were randomised in the second part of the study, with ten participants assigned to ProTrans treatment and five to placebo. All participants were analysed for the primary and secondary outcomes. No serious adverse events related to treatment were observed and, overall, few adverse events (mainly mild upper respiratory tract infections) were reported in the active treatment and placebo arms. The primary efficacy endpoint was defined as Delta-change in C-peptide AUC for a mixed meal tolerance test at 1 year following ProTrans/placebo infusion compared with baseline performance prior to treatment. C-peptide levels in placebo-treated individuals declined by 47%, whereas those in ProTrans-treated individuals declined by only 10% (p<0.05). Similarly, insulin requirements increased in placebo-treated individuals by a median of 10 U/day, whereas insulin needs of ProTrans-treated individuals did not change over the follow-up period of 12 months (p<0.05).Conclusions/interpretation This study suggests that allogeneic Wharton's jelly-derived MSCs (ProTrans) is a safe treatment for recent-onset type 1 diabetes, with the potential to preserve beta cell function.
29.	Carlsson, Sofia, et al. (författare) Body mass index and mortality : is the association explained by genetic factors? 2011 Ingår i: Epidemiology. - 1044-3983 .- 1531-5487. ; 22:1, s. 98-103 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Numerous studies have shown that higher body mass index (BMI) is associated with higher mortality. We investigated the extent to which this association might be explained by genetic factors. METHODS: We used data from the Swedish Twin Registry on twins born 1886-1958 who answered a questionnaire in 1969/1970 or 1972 (n = 44,258). Information on mortality from all-causes (n = 14,217), cardiovascular disease (CVD; n = 9009), and coronary heart disease (CHD; n = 3564) was obtained by linkage to the national Causes of Death Registry for the years 1972-2004. The association between BMI and mortality was studied without control for genetic factors in cohort analyses and with control for genetic factors in co-twin control analyses. RESULTS: In cohort analyses, there was a clear dose-response relationship between BMI and mortality. Hazard ratios per 1 unit increase in BMI in subjects with BMI ≥18.5 were 1.05 (95% confidence interval = 1.05-1.06) for all-cause mortality, 1.07 (1.07-1.09) for CVD mortality, and 1.09 (1.08-1.10) for CHD mortality. Similar results were seen in co-twin control analyses of dizygotic twins. However, within monozygotic twins, BMI was associated with death from CHD (OR = 1.06; 1.00-1.12), whereas the association with all-cause mortality (1.01, 0.98-1.04) and CVD mortality (1.02, 0.98-1.06) was weak. CONCLUSIONS: Our findings indicate that there is an association between high BMI and mortality from CHD that is not explained by genetic confounding. However, a large part of the association between BMI and other causes of death may be explained by genes rather than by a causal link between these factors.
30.	Carlsson, Sofia, et al. (författare) Dependence on Vitamin K-dependent Protein S for Eukaryotic Cell Secretion of the β-Chain of C4b-binding Protein 2010 Ingår i: Journal of Biological Chemistry. - : The American Society for Biochemistry and Molecular Biology. - 0021-9258 .- 1083-351X. ; 285:42, s. 32038-32046 Tidskriftsartikel (refereegranskat)abstract The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 α-chains and 1 β-chain (C4BPβ+), the chains being linked by disulfide bridges. PS binds to the β-chain with high affinity. In plasma, PS is in molar excess over C4BPβ+ and due to the high affinity, all C4BPβ+ molecules contain a bound PS. Taken together with the observation that PS-deficient patients have decreased levels of C4BPβ+, this raises the question of whether PS is important for secretion of the β-chain from the cell. To test this hypothesis, HEK293 cells were stably and transiently transfected with β-chain cDNA in combinations with cDNAs for PS and/or the α-chain. The concentration of β-chains in the medium increased after co-transfection with PS cDNA, but not by α-chain cDNA, suggesting secretion of the β-chains from the cells to be dependent on concomitant synthesis of PS, but not of the α-chains. Thus, β-chains that were not disulfide-linked to the α-chains were secreted in complex with PS, either as monomers or dimers. Pulse-chase demonstrated that the complexes between PS and β-chain were formed intracellularly, in the endoplasmic reticulum. In conclusion, our results demonstrate that successful secretion of β-chains depends on intracellular complex formation with PS, but not on the α-chains. This provides an explanation for the decreased β-chain levels observed in PS-deficient patients.
31.	Carlsson, Sofia, et al. (författare) Genetic effects on physical activity : results from the Swedish Twin Registry 2006 Ingår i: Medicine & Science in Sports & Exercise. - : Ovid Technologies (Wolters Kluwer Health). - 0195-9131 .- 1530-0315. ; 38:8, s. 1396-1401 Tidskriftsartikel (refereegranskat)abstract PURPOSE: The aim of this study was to investigate the genetic effects on leisure-time physical activity using data from the Swedish Twin Registry. METHODS: We investigated 13,362 twin pairs (5334 monozygotic and 8028 dizygotic pairs) aged 14-46 yr. Information on leisure-time physical activity was obtained by questionnaire. Correlations and odds ratios of physical activity were calculated for males, females, and monozygotic and dizygotic twins, respectively. Structural equation modeling was used to estimate the contribution of genetic effects as well as common and nonshared environmental factors on leisure-time physical activity. RESULTS: About one third of the twins reported that they exercised regularly (26% in females and 39% in males). The correlations of physical activity were twice as high in monozygotic compared with dizygotic twins, suggesting the presence of genetic effects. The variation in physical activity due to heritage was 57% (95% confidence interval (CI) = 0.49-0.63) in males and 50% (95% CI = 0.49-0.55) in females. The common environmental influence on physical activity was very small compared with the influence from environmental factors unique to the individual. CONCLUSIONS: Our study establishes heredity as an important component behind individual differences in physical activity in adult men and women. This may be one reason behind difficulties in convincing people to adopt an active lifestyle. Still, this study shows that there is a substantial influence on physical activity from environmental factors unique to the individual.
32.	Carlsson, Sofia, et al. (författare) Late retirement is not associated with increased mortality, results based on all Swedish retirements 1991-2007 2012 Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 27:6, s. 483-486 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract In their recent paper based on German old-age pensioners, Kühntopf and Tivig [1] show that early retirement is associated with considerably higher mortality in men. This is in line with previous reports from British, Danish, US, German and Greek populations showing an increased mortality risk related to retirement, especially in the case of early retirement [2–6]. As pointed out by Kühntopf and Tivig, interpretation of these results is complicated, since a “Healthy worker selection effect” may be operating. To reduce this bias, they used information on credited periods of disease in the public insurance system [1]. Other strategies include adjustment for baseline medical problems [2, 6], using a time lag during follow up [5] or exclusion of subjects retiring for health reasons [3, 4]. It is however questionable, whether these strategies have been sufficient to eliminate the effect of health on retirement.
33.	Carlsson, Sofia, et al. (författare) Low physical activity and mortality in women : Baseline lifestyle and health as alternative explanations 2006 Ingår i: Scandinavian Journal of Public Health. - Karolinska Inst, Div Epidemiol & Social Med, Stockholm Ctr Publ Hlth, Stockholm, Sweden. Karolinska Inst, Dept Epidemiol, Inst Environm Med, Stockholm, Sweden. Karolinska Inst, Dept Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden. : SAGE PUBLICATIONS LTD. - 1403-4948 .- 1651-1905. ; 34:5, s. 480-487 Tidskriftsartikel (refereegranskat)abstract Aims: The aim of this study was to investigate the association between physical activity and mortality in post-menopausal women. In addition, the authors wanted to investigate to what extent this association could be attributed to confounding from other lifestyle factors, and to reverse causation due to a number of common health problems that may inhibit the ability to exercise. Methods: A total of 27,734 women aged 51-83 years from the Swedish Mammography Cohort were investigated. In 1997 they responded to a detailed questionnaire including questions on physical activity, diet, alcohol intake, smoking, and medical problems. During follow-up in 1999-2004, 1,232 deaths were identified by linkage to the National Population Register. Results: Women with low physical activity (<= 35 METh/day) had a 3.22 times increased mortality (95% confidence interval (CI)=2.35-4.43) compared with the most active women (> 50 METh/day). No increased risk was seen in women with moderate compared with high physical activity. Sedentary women tended to have a less healthy lifestyle and more health problems at baseline, e. g. almost 30% of them reported high blood pressure compared with less than 20% of active women. Baseline medical problems and lifestyle factors such as smoking, diet, and education accounted for 30% of the excess risk seen in sedentary women (24% and 6% respectively). Conclusions: This study indicates that even fairly small amounts of activity will reduce mortality in older women. However, sedentary women seemed to be a selected group with more medical problems and a less healthy lifestyle. The findings indicate that the association between physical inactivity and mortality will be overestimated if this is not taken into account.
34.	Carlsson, Sofia, et al. (författare) Physical activity and mortality : is the association explained by genetic selection? 2007 Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 166:3, s. 255-259 Tidskriftsartikel (refereegranskat)abstract Public health recommendations promote physical activity to improve health and longevity. Recent data suggest that the association between physical activity and mortality may be due to genetic selection. Using data on twins, the authors investigated whether genetic selection explains the association between physical activity and mortality. Data were based on a postal questionnaire answered by 13,109 Swedish twin pairs in 1972. The national Cause of Death Register was used for information about all-cause mortality (n=1,800) and cardiovascular disease mortality (n=638) during 1975-2004. The risk of death was reduced by 34% for men (relative risk=0.64, 95% confidence interval: 0.50, 0.83) and by 25% for women (relative risk=0.75, 95% confidence interval: 0.50, 1.14) reporting high physical activity levels. Within-pair comparisons of monozygotic twins showed that, compared with their less active co-twin, the more active twin had a 20% (odds ratio=0.80, 95% confidence interval: 0.65, 0.99) reduced risk of all-cause mortality and a 32% (odds ratio=0.68, 95% confidence interval: 0.49, 0.95) reduced risk of cardiovascular disease mortality. Results indicate that physical activity is associated with a reduced risk of mortality not due to genetic selection. This finding supports a causal link between physical activity and mortality.
35.	Carlsson, Sofia (författare) Surface currents and front passages in the northern Kattegat 2007 Rapport (övrigt vetenskapligt/konstnärligt)
36.	Carlsson, Sofia, et al. (författare) Using Twin Controls to Study the Effects of BMI on Mortality 2011 Ingår i: Epidemiology. - 1044-3983 .- 1531-5487. ; 22:1, s. 107-108 Tidskriftsartikel (refereegranskat)
37.	Carlsson, Sofia (författare) Weight history, low birth weight, alcohol consumption and type 2 diabetes 2003 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Type 2 diabetes is an increasing public health problem, currently affecting about 3-4% of the Swedish population. A worldwide increase in the prevalence of the disease has been demonstrated and preventive strategies are needed to turn this trend. Better knowledge about etiologic factors may lead to more specific intervention and prevention of the disease. The aim of this thesis was to contribute to this knowledge by investigating the association between type 2 diabetes and weight history, low birth weight and alcohol consumption. Analyses were based on a cross-sectional study consisting of 3128 middle-aged men of whom 50% had diabetes in close relatives (Stockholm Diabetes Prevention Program (SDPP). During a health examination, 55 cases of type 2 diabetes and 172 cases of impaired glucose tolerance (IGT) were identified by oral glucose tolerance test. In addition, information on previous weight, birth weight, alcohol consumption and other lifestyle factors were obtained by questionnaire. Analyses of alcohol and type 2 diabetes were also performed in a large prospective study based on the Finnish Twin Cohort. This Cohort was compiled in 1974 and consists of about 16,000 twin pairs. In 1975, 1981 and 1990, subjects were investigated by questionnaire on health and lifestyle factors, including alcohol. By record linkage to registers of hospital discharge and prescribed medication we identified incident cases of diabetes 1976- 1995. A clinical study performed within the Cohort was used to investigate the validity of questionnaire information on alcohol. In this study, information on alcohol by questionnaire, by interview and through three biochemical indicators of alcohol intake; CDT, gamma-GT and MCV was obtained for a sub-sample of 76 twin pairs. The results indicated that the prevalence of type 2 diabetes and impaired glucose tolerance increases with duration of obesity. The odds ratio (OR) of diabetes associated with a short (<5 years) and long (>=10 years) duration of overweight (BMI >25.0 kg/M2) was estimated at 1.9 (95% confidence interval (Cl)=0.5-7. 1) and 7.3 (95% CI=2.2-23.7), respectively. Low birth weight (<3000g) was associated with an increased prevalence of diabetes (OR=4.5, 95% CI=1.9-10.8) and of IGT (OR=1.9, 95% CI=1.0-3.4) after adjustment for family history of diabetes. A particularly high prevalence of diabetes was seen in men with a family history of diabetes in combination with low birth weight, (OR= 10.9 (95% C1=2.9-41.2). Results from SDPP and from the Finnish Twin Cohort were compatible with a reduced risk of diabetes in moderate consumers of alcohol among men, (OR=0.7, 95% CI=0.3-1.8), and RR=0.7 (95% CI=0.5-1.1), respectively. High alcohol intake was associated with an increased prevalence of diabetes in men of SDPP (OR=2.1 (95 % CI=1.0-4.5) but not in the Finnish Twin Cohort. Binge drinking in women of the Finnish Twin Cohort was associated with an increased risk (RR=2.1, 95% CI=1.0-4.4). Comparison of questionnaire information on alcohol to dietary interview information and biochemical indicators indicated that the questionnaire had a rather low sensitivity but high specificity for identification of high consumers. In conclusion, the results of this thesis suggest that a long duration of obesity is an important risk factor for type 2 diabetes in addition to degree and distribution of obesity. The results are consistent with previous studies indicating that low birth weight is associated with type 2 diabetes and expands current knowledge by showing that this association is not explained by family history of diabetes. However, men with the combination of low birth weight and family history of diabetes may be particularly prone to develop the disease. Results from this thesis also provide support for the hypothesis that moderate alcohol consumption reduces the risk of type 2 diabetes.
38.	Correa-Marinez, Adiela, et al. (författare) Stoma-related complications: a report from the Stoma-Const randomized controlled trial 2021 Ingår i: Colorectal Disease. - : Wiley. - 1462-8910 .- 1463-1318. ; 23:5, s. 1091-1101 Tidskriftsartikel (refereegranskat)abstract Aim: The impact of construction techniques on the development of stoma complications is partly undiscovered. The aim of this paper was to report and analyse the impact of the three surgical techniques in a randomized controlled trial Stoma-Const on stoma-related complications as well as identifying risk factors and patient-reported stoma function as a planned secondary analysis. Methods: This was a randomized, multicenter trial where all patients scheduled to receive an end colostomy were invited to participate. Patients were randomized to one of three techniques for stoma construction; cruciate fascial incision, circular incision or prophylactic mesh. Stoma complications were assessed by a surgeon and stoma care nurses within 1 year postoperatively. Results: Two hundred and nine patients were randomized. Patient demographics were similar in all three groups. Data on stoma-related complications were available for analysis in 201 patients. A total of 127 patients (63%) developed some type of stoma complication within 1 year after surgery. The risk ratio (95% CI) for stoma complications was 0.93 (0.73; 1.2) between cruciate vs. circular incision groups and 1.02 (0.78; 1.34) between cruciate vs. mesh groups. There were no statistically significant differences between the groups regarding parastomal hernia rate and no risk factors could be identified. Conclusion: This randomized trial confirmed a high prevalence of stoma-related complications but could not identify an impact of surgical technique or identify modifiable risk factors for stoma-related complications.
39.	Davidsson, Sabina, 1972-, et al. (författare) Soluble Levels of CD163, PD-L1, and IL-10 in Renal Cell Carcinoma Patients 2022 Ingår i: Diagnostics. - : MDPI. - 2075-4418. ; 12:2 Tidskriftsartikel (refereegranskat)abstract CD163+ M2 macrophages have been suggested to counteract tumor immunity by increasing immunosuppressive mechanisms including PD-L1 and IL-10 expression. Soluble levels of PD-L1, IL-10, and CD163 have been reported as potential biomarkers in various cancers, although the prognostic value in renal cell carcinoma (RCC) has to be further elucidated. In the present study, we measured the levels of sPD-L1, sIL-10, and sCD163 in 144 blood samples from patients with RCC. The levels were determined by using enzyme linked immunosorbent assays. Soluble PD-L1 and CD163 were detectable in 100% of the serum samples, and sCD163 in 22% of the urine samples, while only a minority of the samples had detectable sIL-10. Significantly higher serum levels of sPD-L1 and sCD163 were observed in patients with metastatic disease (p < 0.05). The results also showed that patients with high levels of sPD-L1 in serum had shorter cancer-specific survival compared with patients with low levels (p = 0.002). The results indicate that sPD-L1 most significantly reflects tumor progression in RCC.
40.	Deleskog, Anna, et al. (författare) Maternal diabetes and incidence of childhood cancer : a nationwide cohort study and exploratory genetic analysis 2017 Ingår i: Clinical Epidemiology. - 1179-1349. ; 9, s. 633-642 Tidskriftsartikel (refereegranskat)abstract Background: The etiology of childhood cancer is not well understood, but may be linked to prenatal and perinatal factors, such as maternal diabetes. However, this association has not been examined in depth. We aimed to determine if maternal diabetes is associated with risk of childhood brain tumor (CBT), leukemia (all types combined and acute lymphoblastic leukemia [ALL] separately), and lymphoma.Methods: All children born in Sweden between 1973 and 2014 (n= 4,239,965) were followed from birth until first cancer diagnosis, age 15 years, or December 31, 2015. Data on maternal diabetes, childhood cancer, and covariates were obtained from nationwide health registers. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using Cox regression adjusted for potential confounders/mediators. Additionally, we performed an exploratory analysis using results from published genome-wide association studies and functional annotation.Results: Maternal diabetes was associated with lower risk of CBT (adjusted IRR [95% CI]: 0.56 [0.35-0.91]) and higher risk of leukemia (adjusted IRR: 1.47 [1.13-1.92] for all leukemia combined and 1.64 [1.23-2.18] for ALL). These associations were similar for both maternal type 1 diabetes and gestational diabetes. Associations of five previously identified genetic loci were compatible with a causal effect of diabetes traits on neuroblastoma and common Hodgkin's lymphoma.Conclusion: Children whose mother had diabetes had lower risk of CBT and higher risk of leukemia, compared with children whose mother did not have diabetes. Our results are compatible with a role of prenatal and perinatal glycemic environment in childhood cancer etiology.
41.	Edstorp, Jessica, et al. (författare) Does a prior diagnosis of infectious disease confer an increased risk of latent autoimmune diabetes in adults? 2024 Ingår i: Diabetes/Metabolism Research and Reviews. - 1520-7552. ; 40:3, s. e3758- Tidskriftsartikel (refereegranskat)abstract Aims: Infections are proposed risk factors for type 1 diabetes in children. We examined whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults (LADA). Materials and methods: We used data from a population-based Swedish case-control study with incident cases of LADA (n = 597) and matched controls (n = 2386). The history of infectious disease was ascertained through national and regional patient registers. We estimated adjusted odds ratios (OR) with 95% confidence intervals for ≥1 respiratory (any/upper/lower), gastrointestinal, herpetic, other or any infectious disease episode, or separately, for 1 and ≥2 infectious disease episodes, within 0–1, 1–3, 3–5 and 5–10 years before LADA diagnosis/matching. Stratified analyses were performed on the basis of HLA risk genotypes and Glutamic acid decarboxylase antibodies (GADA) levels. Results: Individuals who developed LADA did not have a higher prevalence of infectious disease 1–10 years before diabetes diagnosis. For example, OR was estimated at 0.87 (0.66, 1.14) for any versus no respiratory infectious disease within 1–3 years. Similar results were seen for LADA with high-risk HLA genotypes (OR 0.95 [0.64, 1.42]) or high GADA levels (OR 1.10 [0.79, 1.55]), ≥2 episodes (OR 0.89 [0.56, 1.40]), and in infections treated using antibiotics (OR 1.03 [0.73, 1.45]). The only significant association was observed with lower respiratory disease the year preceding LADA diagnosis (OR 1.67 [1.06, 2.64]). Conclusions: Our findings do not support the idea that exposure to infections increases the risk of LADA. A higher prevalence of respiratory infection in the year before LADA diagnosis could reflect increased susceptibility to infections due to hyperglycemia.
42.	Edstorp, Jessica, et al. (författare) Incidence of lada and type 2 diabetes in relation to tobacco use and genetic susceptibility to type 2 diabetes and related traits : Findings from a swedish case-control study and the norwegian hunt study 2023 Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 46:5, s. 1028-1036 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) aggravate these associations. RESEARCH DESIGN AND METHODS We used data from two population-based Scandinavian studies with case subjects with LADA (n = 839) and T2D (n = 5,771), matched control subjects (n = 3,068), and 1,696,503 person-years at risk. Pooled, multivariate relative risks (RR) with 95% CI were estimated for smoking/genetic risk scores (T2D-GRS, IS-GRS, and IR-GRS), and ORs for snus or tobacco/GRS (case-control data). We estimated additive (proportion attributable to interaction [AP]) and multiplicative interaction between tobacco use and GRS. RESULTS The RR of LADA was elevated in high IR-GRS heavy smokers (‡15 pack-years; RR 2.01 [CI 1.30, 3.10]) and tobacco users (‡15 box/pack-years; RR 2.59 [CI 1.54, 4.35]) compared with low IR-GRS individuals without heavy use, with evidence of additive (AP 0.67 [CI 0.46, 0.89]; AP 0.52 [CI 0.21, 0.83]) and multiplicative (P = 0.003; P = 0.034) interaction. In heavy users, there was additive interaction between T2D-GRS and smoking, snus, and total tobacco use. The excess risk conferred by tobacco use did not differ across GRS categories in T2D. CONCLUSIONS Tobacco use may confer a higher risk of LADA in individuals with genetic susceptibility to T2D and insulin resistance, whereas genetic susceptibility does not seem to influence the increased T2D incidence associated with tobacco use.
43.	Edstorp, Jessica, et al. (författare) Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults 2023 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 66, s. 70-81 Tidskriftsartikel (refereegranskat)abstract Aims/hypotheses: Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults (LADA) and elucidated potential interaction with HLA high-risk genotypes. Methods: Analyses were based on Swedish case–control data (collected 2010–2019) with incident cases of LADA (n=593) and type 2 diabetes (n=2038), and 3036 controls, and Norwegian prospective data (collected 1984–2019) with incident cases of LADA (n=245) and type 2 diabetes (n=3726) during 1,696,503 person-years of follow-up. Pooled RRs with 95% CIs were estimated for smoking, and ORs for snus use (case–control data only). The interaction was assessed by attributable proportion (AP) due to interaction. A two-sample Mendelian randomisation (MR) study on smoking and LADA/type 2 diabetes was conducted based on summary statistics from genome-wide association studies. Results: Smoking (RRpooled 1.30 [95% CI 1.06, 1.59] for current vs never) and snus use (OR 1.97 [95% CI 1.20, 3.24] for ≥15 box-years vs never use) were associated with an increased risk of LADA. Corresponding estimates for type 2 diabetes were 1.38 (95% CI 1.28, 1.49) and 1.92 (95% CI 1.27, 2.90), respectively. There was interaction between smoking and HLA high-risk genotypes (AP 0.27 [95% CI 0.01, 0.53]) in relation to LADA. The positive association between smoking and LADA/type 2 diabetes was confirmed by the MR study. Conclusions/interpretation: Our findings suggest that tobacco use increases the risk of LADA and that smoking acts synergistically with genetic susceptibility in the promotion of LADA. Data availability: Analysis codes are shared through GitHub (https://github.com/jeseds/Smoking-use-of-smokeless-tobacco-HLA-genotypes-and-incidence-of-LADA). Graphical abstract: [Figure not available: see fulltext.]
44.	Erestam, Sofia, et al. (författare) Associations between intraoperative factors and surgeons' self-assessed operative satisfaction. 2020 Ingår i: Surgical endoscopy. - : Springer Science and Business Media LLC. - 1432-2218 .- 0930-2794. ; 34:1, s. 61-68 Tidskriftsartikel (refereegranskat)abstract Little is known concerning what may influence surgeon satisfaction with a surgical procedure and its associations with intraoperative factors. The objective was to explore the relationships between surgeons' self-assessed satisfaction with performed radical prostatectomies and intraoperative factors such as technical difficulties and intraoperative complications as reported by the surgeon subsequent to the operation.We utilized prospectively collected data from the controlled LAPPRO trial where 4003 patients with prostate cancer underwent open (ORP) or robot-assisted laparoscopic (RALP) radical prostatectomy. Patients were included from fourteen centers in Sweden during 2008-2011. Surgeon satisfaction was assessed by questionnaires at the end of each operation. Intraoperative factors included time for the surgical procedure as well as difficulties and complications in various steps of the operation. To model surgeon satisfaction, a mixed effect logistic regression was used. Results were presented as odds ratios (OR) with 95% confidence intervals (CI).The surgeons were satisfied in 2905 (81%) and dissatisfied in 702 (19%) of the surgical procedures. Surgeon satisfaction was not statistically associated with type of surgical technique (ORP vs. RALP) (OR 1.36, CI 0.76; 2.43). Intraoperative factors such as technical difficulties or complications, for example, suturing of the anastomosis was negatively associated with surgeon satisfaction (OR 0.24, CI 0.19; 0.30).Our data indicate that technical difficulties and/or intraoperative complications were associated with a surgeon's level of satisfaction with an operation.
45.	Erlandsson, Martin, et al. (författare) SIRII SPINE documented and quality reviewed environmental data 2003 Rapport (övrigt vetenskapligt/konstnärligt)abstract One of the most significant obstacles in working with LCA and other system analytical tools where enviromental data are used, is the availability of adequate and well-documented inventory (environmental) data. Furthermore, it is preferable if the quality data has been reviewed to some degree. Both process knowledge and environmental competence are needed in order to review environmental data. The Sirii Environmental Data Network holds this unique competence profile, which enables the network to review environmental data with respect to the correctness of documentation as well as the reasonableness of the numerical value. The routine for review of Sirii SPINE documented data is presented in this report.
46.	Erlandsson, Martin, et al. (författare) Sirii SPINE dokumenterade och kvalitetssäkrade miljödata 2002 Rapport (övrigt vetenskapligt/konstnärligt)abstract Det är allmänt känt att en av de viktigaste begränsningarna i arbetet med LCA och andra systemanalytiska verktyg som använder numeriska miljödata, är tillgången på väldokumenterade inventeringsdata. Det är vidare önskvärt att data är kvalitetssäkrade i någon bemärkelse. För att kunna kvalitetssäkra miljödata krävs både processkunnande och miljökompetens. Denna unika kompetensprofil besitter Sirii Miljödata Nätverk. En sådan kompetensprofil gör det möjligt att inte bara kvalitetssäkra miljödata med avseende på dokumentationens riktighet, utan även med avseende på rimligheten i de numeriska värdena. Rutinen för denna kvalitetssäkring finns redovisad i denna rapport.
47.	Gabrielsson, Britt, 1957, et al. (författare) Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice 2012 Ingår i: International Journal of Molecular Medicine. - : Spandidos Publications. - 1107-3756 .- 1791-244X. ; 29:3, s. 331-37 Tidskriftsartikel (refereegranskat)abstract Diet is a significant modifiable risk factor for cardiovascular disease and high fish intake has been associated with vascular health in population studies. However, intervention studies have been inconclusive. In this study, male low-density lipoprotein receptor-deficient mice were given 16-week high fat/high sucrose diets, supplemented with either minced herring fillets or minced beef. The diets were matched in total fat and cholesterol content; taurine content and fatty acid composition was analysed. Body weights were recorded throughout the study; plasma lipids were analysed at week 8 and 16. Body composition and adipocyte size were evaluated at study end. Atherosclerosis was evaluated at week 12 (ultrasound) and at termination (en face histology). Herring-fed mice had a higher proportion of long-chain n-3 polyunsaturated fatty acids in the hepatic triacylglycerides (TAG) and phospholipid fractions. The herring-fed mice had increased body weight (P=0.007), and reduced epididymal adipocyte size (P=0.009), despite similar food intake and body composition as the beef-fed mice. The herring-fed mice had lower plasma TAG and very-low-density lipoprotein (VLDL)-cholesterol concentrations throughout the study (TAG; P=0.0012 and 0.004, VLDL-cholesterol; P=0.006 and 0.041, week 8 and 16, respectively). At week 16, the herring-fed had higher plasma concentrations of HDL-cholesterol (P=0.004) and less atherosclerotic lesions in the aortic arch (P=0.007) compared with the beef-fed mice. In conclusion, dietary herring in comparison to beef markedly improved vascular health in this mouse model, suggesting that herring provides an added value beyond its content of macronutrients.
48.	Granér, Simon, et al. (författare) An experimental investigation of behavioural contagion and performance experience in basketball 2012 Ingår i: Swedish Journal of Sport Research. - 2001-6018. Tidskriftsartikel (refereegranskat)
49.	Grapensparr, Liza, et al. (författare) Systemic neural crest stem cell treatment alleviates experimental type 1 diabetes by cellular homing to the damaged islets, inducing beta-cell regeneration Annan publikation (övrigt vetenskapligt/konstnärligt)
50.	Grund, Sofia, et al. (författare) The autocrine motility factor receptor is overexpressed on the surface of B cells in Binet C chronic lymphocytic leukemia. 2011 Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1559-131X .- 1357-0560. ; 28:4, s. 1542-8 Tidskriftsartikel (refereegranskat)abstract Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a clinical spectrum reaching from discrete lymphocytosis to extensive enlargement of lymph nodes, spleen and liver, and bone marrow failure. The aim of this study was to identify genes that differentiate between patients with disease stage A vs. C according to Binet in order to better understand the disease. To achieve this, we performed DNA microarray analysis on B cells from CLL patients with stage A and C according to Binet and matched controls. Between CLL patients and controls, there were 1,528 differentially expressed genes and 360 genes were differentially expressed between Binet A and C patients. Due to the sheer number of regulated genes, we focused on the autocrine motility factor receptor (AMFR). AMFR has not previously been investigated in hematological disorders, but high expression of AMFR correlates with a more advanced stage and invasive potential in several human tumors. AMFR mRNA expression was higher in Binet A compared with Binet C patients (P=0.0053) and healthy controls (P=0.0051). Total AMFR protein was higher in Binet A patients compared to Binet C as analyzed by intracellular flow cytometry. However, AMFR exist both in the ER involved in protein degradation and on the cell surface involved in metastasis and cell motility. Cell surface AMFR was increased in Binet C compared with Binet A+B (P=0.016). In conclusion, the mRNA levels reflect the total amount of AMFR, whereas cell surface expression is associated with progression in CLL.

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