| 1. |
|
|
| 2. |
- Santangelo, James S., et al.
(författare)
-
Global urban environmental change drives adaptation in white clover
- 2022
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375
-
Tidskriftsartikel (refereegranskat)abstract
- Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural dines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale.
|
|
| 3. |
- Anchordoqui, Luis A., et al.
(författare)
-
The Forward Physics Facility : Sites, experiments, and physics potential
- 2022
-
Ingår i: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 968, s. 1-50
-
Tidskriftsartikel (refereegranskat)abstract
- The Forward Physics Facility (FPF) is a proposal to create a cavern with the space and infrastructure to support a suite of far-forward experiments at the Large Hadron Collider during the High Luminosity era. Located along the beam collision axis and shielded from the interaction point by at least 100 m of concrete and rock, the FPF will house experiments that will detect particles outside the acceptance of the existing large LHC experiments and will observe rare and exotic processes in an extremely low-background environment. In this work, we summarize the current status of plans for the FPF, including recent progress in civil engineering in identifying promising sites for the FPF and the experiments currently envisioned to realize the FPF's physics potential. We then review the many Standard Model and new physics topics that will be advanced by the FPF, including searches for long-lived particles, probes of dark matter and dark sectors, high-statistics studies of TeV neutrinos of all three flavors, aspects of perturbative and non-perturbative QCD, and high-energy astroparticle physics.
|
|
| 4. |
|
|
| 5. |
- Carmona, Matthew, et al.
(författare)
-
Public Places – Urban Spaces : The Dimensions of Urban Design
- 2010
-
Bok (refereegranskat)abstract
- Public Places Urban Spaces 2e is a thorough introduction to the principles of urban design theory and practice. Authored by experts in the fields of urban design and planning, it is designed specifically for the 2500 postgraduate students on Urban Design courses in the UK, and 1500 students on undergraduate courses in the same subject. The second edition of this tried and trusted textbook has been updated with relevant case studies to show students how principles have been put into practice. The book is now in full colour and a larger format, so students and lecturers get a much stronger visual package and easy to use layout, enabling them to more easily practically apply principles of urban design to their projects. Sustainability is the driving factor in urban regeneration and new urban development, and the new edition is focused on best sustainable design and practice
|
|
| 6. |
- Carmona, Matthew, et al.
(författare)
-
Public space in an age of austerity
- 2019
-
Ingår i: Urban Design International. - : Springer. - 1357-5317 .- 1468-4519. ; 24:4, s. 241-259
-
Tidskriftsartikel (refereegranskat)abstract
- Through an overview of the decade 2008 to 2017, and looking comparatively across four northern European cities, this paper reflects on the changing nature of public space during these austerity years and on the processes of shaping public spaces. The paper draws from the experiences of London, Copenhagen, Malmo and Oslo to explore processes of the design, development, use and management of public spaces during this period. The evidence suggests that we have witnessed a period of significant innovation, side by side with major challenges to the collective approach to public spaces. This has led to distinct forms of public spaces that for good or ill have multiplied as a result of the trends discussed in the paper, spaces of; expectation; the private/public sphere; spectacle; respite; infrastructure; diversion; income generation; security; the ephemeral city; community control; occupation; disadvantage; and decline. Episodes of changing practice are set out in the paper and cumulatively reveal distinct and significant changes during the austerity era, although not necessarily in the manner that might have been expected. Instead, in these four cities, the impact of austerity seems to have been eclipsed by other evolving and competing public policy goals, and by the evolving range of public space types.
|
|
| 7. |
- Chapman, David, 1972-
(författare)
-
Patterning the Dutch Compact City
- 2001
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A major challenge to town planners in Britain is to help fulfil current and future housing need in a sustainable manner and avoid excessive development land take.This thesis therefore establishes what future development models are currently under debate and undertakes extensive research into Governments preferred option the 'Compact City'. Research focuses on empirical data for sustainable development and arguments for/against a policy of urban intensification.On conclusion that research alone fails to provide a sufficient basis for promoting a policy of 'Compact Cities', research emphasis was placed on the Dutch planning system, which has promoted such a policy for over a quarter of a century. Dutch experience was used to answer many unresolved arguments surrounding the 'Compact City' and an investigation was undertaken into how the Dutch have made this policy successful.In light of the fact that Dutch experience has shown that high quality urban housing is fundamental to attracting residents back to cities, an investigation of current UK generic housing models was undertaken and these were tested against sustainable density research and UK/Dutch design advice. On comparison it was established that many failed both tests and it was established that additional housing types could be required under a policy of 'Compact Cities'. An alternative development brief for additional housing models was therefore developed and this brief was investigated through the design of three alternative housing types.In final conclusion it was proposed that the Dutch treatment of density could provide a model for future planning in England and their design principles could aid the creation of alternative urban housing types.
|
|
| 8. |
- Johnson, Graham T., et al.
(författare)
-
Building the next generation of virtual cells to understand cellular biology
- 2023
-
Ingår i: Biophysical Journal. - : Elsevier BV. - 0006-3495 .- 1542-0086. ; 122:18, s. 3560-3569
-
Tidskriftsartikel (refereegranskat)abstract
- Cell science has made significant progress by focusing on understanding individual cellular processes through reductionist approaches. However, the sheer volume of knowledge collected presents challenges in integrating this information across different scales of space and time to comprehend cellular behaviors, as well as making the data and methods more accessible for the community to tackle complex biological questions. This perspective proposes the creation of next-generation virtual cells, which are dynamic 3D models that integrate information from diverse sources, including simulations, biophysical models, image-based models, and evidence-based knowledge graphs. These virtual cells would provide statistically accurate and holistic views of real cells, bridging the gap between theoretical concepts and experimental data, and facilitating productive new collaborations among researchers across related fields.
|
|
| 9. |
- Mayes, Maureen D, et al.
(författare)
-
Immunochip analysis identifies multiple susceptibility Loci for systemic sclerosis.
- 2014
-
Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 94:1, s. 47-61
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising 4,017 SSc cases and 5,935 controls was carried out for several selected non-HLA variants, reaching a total of 5,850 cases and 9,401 controls of European ancestry. Following this strategy, we identified and validated three SSc risk loci, including DNASE1L3 at 3p14, the SCHIP1-IL12A locus at 3q25, and ATG5 at 6q21, as well as a suggested association of the TREH-DDX6 locus at 11q23. The associations of several previously reported SSc risk loci were validated and further refined, and the observed peak of association in PXK was related to DNASE1L3. Our study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
|
|
| 10. |
- Rådestad, Sofie, 1987-
(författare)
-
Engagement in urban planning as a consequence of trust : an explorative study of the Slussen redevelopment project opposition
- 2016
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study is about the phenomenon of trust as applied in urban planning processes. The study views this concept through the lens of “the opposition” – the dissenting voices to the official narratives of urban planning projects. The main focus in this context is Slussen in Stockholm, Sweden, which is a majorly important redevelopment project as well as a source of heated debate. The methodological approach is qualitative research. The data collection relies on interviews and a discourse analysis of text and language. The interviewees are chosen based on their experience of, or participation in, opposition against the Slussen redevelopment project. The theoretical literature and the interviews are analysed through the theoretical framework of Erik Blennberger’s six analytical themes of trust. This enables a systematic detached approach to analysing the subjective interviews as well enabling a comparison between empirical evidence and relevant theoretical literature. This process resulted in seven categories of (dis)trust emerging from the interview material, which in turn resulted in the conclusion that, based on the study’s main findings three factors were the possible reasons behind the opposition of the Slussen redevelopment project: (1) Slussen as a unique space, (2) Debate character, (3) Authority. Based on these empirical findings and their comparison to the theoretical literature, the study concludes that trust depends on people’s perceptions of trustworthy actions of those who initiate change. That by exploring trust in the statements of oppositional networks over time it is possible to better understand issues regarding implementation of urban planning projects.
|
|
