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- Cedergren, Karin, 1975, et al.
(författare)
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Biepitaxial YBa2Cu3O7-x 0-pi Josephson junctions
- 2010
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Ingår i: Superconductor Science and Technology. - : IOP Publishing. - 0953-2048 .- 1361-6668. ; 23:3, s. Article Number: 034027-
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements performed on YBa2Cu3O7-x '0' and '0-pi' Josephson junctions fabricated using the biepitaxial technique with SrTiO3 as substrate and CeO2 as seed layer. Measurements of the critical current as a function of external magnetic field clearly show complementary behavior of the two kinds of junctions. Our results unambiguously show that the d-wave nature of the order parameter dominates the current transport across the junctions despite the faceting on the microscale along the grain boundary line.
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| 4. |
- Cedergren, Karin, 1975, et al.
(författare)
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Interplay between Static and Dynamic Properties of Semifluxons in YBa2Cu3O7−δ 0−π Josephson Junctions
- 2010
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 104:17, s. 177003 -
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Tidskriftsartikel (refereegranskat)abstract
- We have investigated the static and dynamic properties of long YBa2Cu3O7-delta 0-pi Josephson junctions and compared them with those of conventional 0 junctions. Scanning SQUID microscope imaging has revealed the presence of a semifluxon at the phase discontinuity point in 0-pi Josephson junctions. Zero field steps have been detected in the current-voltage characteristics of all junctions. Comparison with simulation allows us to attribute these steps to fluxons traveling in the junction for conventional 0 junctions and to fluxon-semifluxon interactions in the case of 0-pi Josephson junctions.
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- Hassel, H., et al.
(författare)
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Developing a framework for characterising cascading failures in past events to inform emergency response decisions
- 2015
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Ingår i: Safety and Reliability : Methodology and Applications - Proceedings of the European Safety and Reliability Conference, ESREL 2014 - Methodology and Applications - Proceedings of the European Safety and Reliability Conference, ESREL 2014. - : CRC Press. - 9781138026810 - 9781315736976 ; , s. 33-42
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Konferensbidrag (refereegranskat)abstract
- Increasing interdependencies between critical infrastructures have made these systems more effective, but also more susceptible to cascading failures. In order to reduce the likelihood and consequences of cascading failures, it is essential to develop tools that support incident commander decisions so that an initial failure does not spread to other infrastructures. Here, a framework for generating knowledge from previous events that can feed in to such a tool is outlined. Design science is used to this end which provides a transparent and systematic approach. Moreover, the paper presents an analysis of existing empirical approaches focusing on identifying methodological aspects that can influence the framework. Although further work is needed, the work presented in this paper shows a promising first step to accomplish such a framework.
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- Kastbom, Alf, et al.
(författare)
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Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis
- 2013
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 42:6, s. 465-468
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is important for interleukin-1beta (IL-1 beta) processing as part of an innate immune response. Caspase recruitment domain family, member 8 (CARD8) is an inhibitor of nuclear factor kappa B (NF-kappa B) and possibly also a part of the NLRP3 inflammasome. The objective of this study was to evaluate one single nucleotide polymorphism (SNP) in CARD8 and three SNPs in NLRP3 in ankylosing spondylitis (AS) susceptibility and disease phenotype. Method: We recruited 492 AS patients from Southern Sweden fulfilling the modified New York criteria for AS, and assessed phenotypic characteristics from medical records and questionnaires. Patients with psoriasis or clinically overt inflammatory bowel disease (IBD) were excluded, as were patients without human leucocyte antigen B27 (HLA-B27). Three NLRP3 SNPs (rs35829419, rs4353135, and rs10733113) and one SNP in CARD8 (rs2043211) were genotyped by commercially available TaqMan assays, and the results compared at genotype and allele levels to those of 793 population-based controls. In a subgroup of the patients (n = 169), faecal calprotectin was assessed as a marker of subclinical intestinal inflammation. Results: The minor allele (A) of CARD8-C10X (rs2043211) was associated with a decreased risk of AS in a dominant model [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.54-0.94, p = 0.012] and at the allelic level (OR 0.81, 95% CI 0.68-0.97, p = 0.02), but was not associated with levels of faecal calprotectin. There was no association regarding NLRP3 SNPs and AS susceptibility, and none of the investigated SNPs were associated with iritis, anti-tumour necrosis factor (anti-TNF) therapy, or peripheral joint involvement. Conclusion: In a Swedish population, the minor allele of CARD8-C10X is associated with a decreased risk of AS, but not with levels of faecal calprotectin or disease phenotype.
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- Lara Avila, Samuel, 1983, et al.
(författare)
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Disordered Fermi Liquid in Epitaxial Graphene from Quantum Transport Measurements
- 2011
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 107:16, s. 166602-
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Tidskriftsartikel (refereegranskat)abstract
- We have performed magnetotransport measurements on monolayer epitaxial graphene and analyzed them in the framework of the disordered Fermi liquid theory. We have separated the electron-electron and weak-localization contributions to resistivity and demonstrated the phase coherence over a micrometer length scale, setting the limit of at least 50 ps on the spin relaxation time in this material.
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| 9. |
- Meijers, Rob, et al.
(författare)
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On the Enzymatic Activation of NADH
- 2001
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 276:12, s. 9316-9321
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Tidskriftsartikel (refereegranskat)abstract
- Atomic (1 Å) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the crystal structures can only be reproduced when the water is considered a hydroxide ion. These observations provide fundamental insight into the enzymatic activation of NADH for hydride transfer.
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- Morf, Andrea, 1968, et al.
(författare)
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Challenges and Enablers to Integrate Land-Sea-Interactions in Cross-Border Marine and Coastal Planning: Experiences from the Pan Baltic Scope Collaboration
- 2022
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Ingår i: Planning Practice and Research. - : Informa UK Limited. - 0269-7459 .- 1360-0583. ; 37:3, s. 333-354
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Tidskriftsartikel (refereegranskat)abstract
- This paper analyses challenges and enablers for integrating a transboundary land-sea interaction (LSI) perspective into marine spatial planning (MSP) practice as experienced in the Baltic Sea Region. Collaborative research results from the Pan Baltic Scope project indicate that LSI remains an amorphous concept, particularly within a transboundary MSP context. Difficulty lies in bridging planning practices across land and sea and between varying uses, administrative settings and governance functions. Addressing LSI requires capacity, time, resources, awareness, reflection, and forums for collaborative learning across sectors and governance levels.
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| 11. |
- Shang, Ming-Mei, et al.
(författare)
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Lim domain binding 2 : a key driver of transendothelial migration of leukocytes and atherosclerosis
- 2014
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Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - 1079-5642 .- 1524-4636. ; 34:9, s. 2068-2077
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Using a multi-tissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.APPROACH AND RESULTS: mRNA profiles generated from blood macrophages in patients with CAD were used to infer transcription factor regulatory gene networks; Ldlr(-/-)Apob(100/100) mice were used to study the effects of Ldb2 deficiency on TEML activity and atherogenesis. LDB2 was the most connected gene in a transcription factor regulatory network inferred from TEML and atherosclerosis module genes in CAD macrophages. In Ldlr(-/-)Apob(100/100) mice, loss of Ldb2 increased atherosclerotic lesion size ≈2-fold and decreased plaque stability. The exacerbated atherosclerosis was caused by increased TEML activity, as demonstrated in air-pouch and retinal vasculature models in vivo, by ex vivo perfusion of primary leukocytes, and by leukocyte migration in vitro. In THP1 cells, migration was increased by overexpression and decreased by small interfering RNA inhibition of LDB2. A functional LDB2 variant (rs10939673) was associated with the risk and extent of CAD across several cohorts.CONCLUSIONS: As a key driver of the TEML pathway in CAD macrophages, LDB2 is a novel candidate to target CAD by inhibiting the overall activity of TEML.
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| 12. |
- Tzalenchuk, Alexander, et al.
(författare)
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Engineering and metrology of epitaxial graphene
- 2011
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Ingår i: Solid State Communications. - : Elsevier. - 0038-1098 .- 1879-2766. ; 151:16, s. 1094-1099
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Tidskriftsartikel (refereegranskat)abstract
- ere we review the concepts and technologies, in particular photochemical gating, which contributed to the recent progress in quantum Hall resistance metrology based on large scale epitaxial graphene on silicon carbide.
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