| 1. |
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| 2. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 4. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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| 5. |
- Kristanl, Matej, et al.
(författare)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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Ingår i: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 6. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 7. |
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| 8. |
- Mishra, A., et al.
(författare)
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Stroke genetics informs drug discovery and risk prediction across ancestries
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611, s. 115-123
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Tidskriftsartikel (refereegranskat)abstract
- Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
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| 9. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 10. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 11. |
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| 12. |
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| 13. |
- Blokland, G. A. M., et al.
(författare)
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- 2022
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Ingår i: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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| 14. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 15. |
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| 16. |
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| 17. |
- Hu, Ji-Chong, et al.
(författare)
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Oxidation behavior of Ni-based superalloy GH4738 under tensile stress
- 2024
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Ingår i: Rare Metals. - : NONFERROUS METALS SOC CHINA. - 1001-0521 .- 1867-7185.
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Tidskriftsartikel (refereegranskat)abstract
- Revealing the oxidation behavior of superalloys is crucial for optimizing material properties and extending service life. This study investigated the oxidation behavior of superalloy GH4738 under stress states at 850 degrees C. High-throughput specimens were fabricated to withstand different stresses at the same time. Isothermal oxidation samples were analyzed using the mass gain method to obtain oxidation kinetic curves. The results show that the external stress below 200 MPa could improve the oxidation resistance of the GH4738. With tensile stress increasing, the oxide layer becomes thinner, denser and more complete, while internal oxidation decreases. The tensile stress alters the structure of the external oxide layer from a two-layer to a three-layer configuration. The Cr2O3 oxide layer inhibits the outward diffusion of Ti, leading to Ti enrichment at the oxide-matrix interface and altering the oxidation mechanism of GH4738.
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| 18. |
- Jiang, T., et al.
(författare)
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Comparison of hydrological impacts of climate change simulated by six hydrological models in the Dongjiang Basin, South China
- 2007
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Ingår i: Journal of Hydrology. - : Elsevier BV. - 0022-1694 .- 1879-2707. ; 336:3-4, s. 316-333
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Tidskriftsartikel (refereegranskat)abstract
- Large differences in future climatic scenarios found when different global circulation models (GCMs) are employed have been extensively discussed in the scientific literature. However, differences in hydrological responses to the climatic scenarios resulting from the use of different hydrological models have received much less attention. Therefore, comparing and quantifying such differences are of particular importance for the water resources management of a catchment, a region, a continent, or even the globe. This study investigates potential impacts of human-induced climate change on the water availability in the Dongjiang basin, South China, using six monthly water balance models, namely the Thornthwaite–Mather (TM), Vrije Universitet Brussel (VUB), Xinanjiang (XAJ), Guo (GM), WatBal (WM), and Schaake (SM) models. The study utilizes 29-year long records of monthly streamflow and climate in the Dongjiang basin. The capability of the six models in simulating the present climate water balance components is first evaluated and the results of the models in simulating the impact of the postulated climate change are then analyzed and compared. The results of analysis reveal that (1) all six conceptual models have similar capabilities in reproducing historical water balance components; (2) greater differences in the model results occur when the models are used to simulate the hydrological impact of the postulated climate changes; and (3) a model without a threshold in soil moisture simulation results in greater changes in model-predicted soil moisture with respect to alternative climates than the models with a threshold soil moisture. The study provides insights into the plausible changes in basin hydrology due to climate change, that is, it shows that there can be significant implications for the investigation of response strategies for water supply and flood control due to climate change.
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| 19. |
- Kato, Norihiro, et al.
(författare)
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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
- 2015
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 47:11, s. 1282-1293
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Tidskriftsartikel (refereegranskat)abstract
- We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10−6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
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| 20. |
- Kristan, Matej, et al.
(författare)
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The Sixth Visual Object Tracking VOT2018 Challenge Results
- 2019
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Ingår i: Computer Vision – ECCV 2018 Workshops. - Cham : Springer Publishing Company. - 9783030110086 - 9783030110093 ; , s. 3-53
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis and a “real-time” experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. A long-term tracking subchallenge has been introduced to the set of standard VOT sub-challenges. The new subchallenge focuses on long-term tracking properties, namely coping with target disappearance and reappearance. A new dataset has been compiled and a performance evaluation methodology that focuses on long-term tracking capabilities has been adopted. The VOT toolkit has been updated to support both standard short-term and the new long-term tracking subchallenges. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website (http://votchallenge.net).
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| 21. |
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| 22. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 23. |
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| 24. |
- Chen, David, et al.
(författare)
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CHANGE-POINT ALTERATIONS OF EXTREME WATER LEVELS AND UNDERLYING CAUSES IN THE PEARL RIVER DELTA, CHINA
- 2009
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Ingår i: Rivers Research and Applications. - : Wiley. - 1535-1459 .- 1535-1467. ; 25, s. 1153-1168
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the Bayesian model and Lepage test were used to detect change point and to analyse associated statistical properties of high/low water levels in summer (June, July and August (JJA)) and winter (December, January and February (DJF)) months across the PRD (Pearl River Delta). The results indicate that: (1) two time intervals, that is 1979-1981 and 1988-1995, witness abrupt changes of SmH/SmL (summer mean high water level/summer mean low water level). The lower PRD is dominated by increased mean and coefficient of variation (Cv) of SmH. Increased mean but decreased Cv of SmL can be observed in the Mainstem Pearl River; (2) WmL (winter mean low water level) and WmH (winter mean high water level) of about 74% of the total stations have two change points occurred roughly during 1969-1971 and 1993-1995. First change points of WmH are mainly characterized by increased mean and Cv, but decreased mean and increased Cv of WmL can be observed across major parts of the PRD. The driving factors causing abrupt changes of water levels are various. Intensive human activities cannot be ignored, for example in-channel dredging and reallocation of the streamflow within the river channels due to human-induced topographical changes of river channel. Different responses of high/low water levels to externally influencing factors and interactions between influencing factors make the alterations of the water levels across the PRD more complicated. The findings of this paper will be helpful for the management of the PRD and human mitigation to natural hazards under the changing environment. Copyright (C) 2008 John Wiley & Sons, Ltd.
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| 25. |
- Chen, David, et al.
(författare)
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Hydrologic alteration along the Middle and Upper East River (Dongjiang) basin, South China : a visually enhanced mining on the results of RVA method
- 2010
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Ingår i: Stochastic environmental research and risk assessment (Print). - : Springer Science and Business Media LLC. - 1436-3240 .- 1436-3259. ; 24, s. 9-18
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a visually enhanced evaluation of the spatio-temporal patterns of the dam-induced hydrologic alteration in the middle and upper East River, south China over 1952-2002, using the range of variability approach (RVA) and visualization package XmdvTool. The impacts of climate variability on hydrological processes have been removed for wet and dry periods, respectively, so that we focus on the impacts of human activities (i.e., dam construction). The results indicate that: (1) along the East River, dams have greatly altered the natural flow regime, range condition and spatial variability; (2) six most remarkable indicators of hydrologic alteration induced by dam-construction are rise rate (1.16), 3-day maximum (0.91), low pulse duration (0.88), January (0.80), July (0.80) and February (0.79) mean flow of the East River during 1952-2002; and (3) spatiotemporal hydrologic alterations are different among three stations along Easter River. Under the influence of dam construction in the upstream, the degree of hydrologic changes from Lingxia, Heyuan to Longchuan station increases. This study reveals that visualization techniques for high-dimensional hydrological datasets together with RVA are beneficial for detecting spatio-temporal hydrologic changes.
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| 26. |
- Chen, X., et al.
(författare)
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A distributed monthly hydrological model for integrating spatial variations of basin topography and rainfall
- 2007
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 21:2, s. 242-252
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Tidskriftsartikel (refereegranskat)abstract
- Hydrological models at a monthly time-scale are important tools for hydrological analysis, such as in impact assessment of climate change and regional water resources planning. Traditionally, monthly models adopt a conceptual, lumped-parameter approach and cannot account for spatial variations of basin characteristics and climatic inputs. A large requirement for data often severely limits the utility of physically based, distributed-parameter models. Based on the variable-source-area concept, we considered basin topography and rainfall to be two major factors whose spatial variations play a dominant role in runoff generation and developed a monthly model that is able to account for their influences in the spatial and temporal dynamics of water balance. As a hybrid of the Xinanjiang model and TOPMODEL, the new model is constructed by innovatively making use of the highly acclaimed simulation techniques in the two existing models. A major contribution of this model development study is to adopt the technique of implicit representation of soil moisture characteristics in the Xinanjiang model and use the TOPMODEL concept to integrate terrain variations into runoff simulation. Specifically, the TOPMODEL topographic index ln(a/tan) is converted into an index of relative difficulty in runoff generation (IRDG) and then the cumulative frequency distribution of IRDG is used to substitute the parabolic curve, which represents the spatial variation of soil storage capacity in the Xinanjiang model. Digital elevation model data play a key role in the modelling procedures on a geographical information system platform, including basin segmentation, estimation of rainfall for each sub-basin and computation of terrain characteristics. Other monthly data for model calibration and validation are rainfall, pan evaporation and runoff. The new model has only three parameters to be estimated, i.e. watershed-average field capacity WM, pan coefficient and runoff generation coefficient . Sensitivity analysis demonstrates that runoff is least sensitive to WM and, therefore, it can be determined by a prior estimation based on the climate and soil properties of the study basin. The other two parameters can be determined using optimization methods. Model testing was carried out in a number of nested sub-basins of two watersheds (Yuanjiang River and Dongjiang River) in the humid region in central and southern China. Simulation results show that the model is capable of describing spatial and temporal variations of water balance components, including soil moisture content, evapotranspiration and runoff, over the watershed. With a minimal requirement for input data and parameterization, this terrain-based distributed model is a valuable contribution to the ever-advancing technology of hydrological modelling.
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| 27. |
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| 28. |
- Chen, Xi, et al.
(författare)
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Simulating the integrated effects of topography and soil properties on runoff generation in hilly forested catchments, South China
- 2010
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 24:6, s. 714-725
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of runoff components associated with catchment topography and soil properties is critical for planning water resources utilization and evaluating hydrological changes due to artificially induced land surface manipulation. In this study, the modified TOPMODEL by Scanlon et al. (2000) was applied to simulate runoff-generating processes and to separate runoff components in two hilly forested catchments within the Dongjiang Basin of Southeast China. The modified TOPMODEL was improved by integrating an evapotranspiration package with the model algorithms. Influences of catchment topography and soil properties on runoff generation were analysed on the basis of explicit expression of catchment field capacity distribution derived from the topographic index and catchment average field capacity. Study results demonstrate that the model is capable of simulating hydrological processes and separate hydrological components in both hourly and daily time steps. Total runoff generation primarily depends on the effective storage capacity of unsaturated zone. A 50% decrease of the effective storage capacity from 0.22 to 0.11 m over the soil zone leads to a 6.6% increase in total runoff. Topography plays a dominant role in formation of runoff components. When the catchment mean slope increases by 87%, subsurface storm flow could increase by 50% whilst overland flow decreases by 7.5% and baseflow by 6.7%. Vertical changes of soil permeability influence runoff components as well. Decrease of the lower layer hydraulic transmissivity may result in 2-3% increase of overland flow and subsurface storm flow and 5% decrease of baseflow.
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| 29. |
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| 30. |
- Gong, Lebing, et al.
(författare)
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Sensitivity of the Penman–Monteith reference evapotranspiration to key climatic variables in the Changjiang (Yangtze River) basin
- 2006
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Ingår i: Journal of Hydrology. - : Elsevier BV. - 0022-1694 .- 1879-2707. ; 329:3-4, s. 620-629
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Tidskriftsartikel (refereegranskat)abstract
- Sensitivity analysis is important in understanding the relative importance of climatic variables to the variation of reference evapotranspiration (ETref). In this study, a non-dimensional relative sensitivity coefficient was employed to predict responses of ETref to perturbations of four climatic variables in the Changjiang (Yangtze River) basin. ETref was estimated with the FAO-56 Penman–Monteith equation. A 41-year historical dataset of daily air temperature, wind speed, relative humidity and daily sunshine duration at 150 national meteorological observatory stations was used in the analysis. Results show that the response of ETref can be precisely predicted under perturbation of relative humidity or shortwave radiation by their sensitivity coefficients; the predictive power under perturbations of air temperature and wind speed depended on the magnitude of the perturbation, season and region. The prediction errors were much smaller than the seasonal and regional variation of their sensitivity coefficients. The sensitivity coefficient could also be used to predict the response of ETref to co-perturbation of several variables. The accuracy of the prediction increases from the lower to the upper region. Spatial variations of long-term average monthly and yearly sensitivity coefficients were obtained by interpolation of station estimates. In general, relative humidity was the most sensitive variable, followed by shortwave radiation, air temperature and wind speed. The actual rank of the four climatic variables in terms of their sensitivity varied with season and region. The large spatial variability of the sensitivity coefficients of all the climatic variables in the middle and lower regions of the basin was to a large extent determined by the distinct wind-speed patterns in those two regions.
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| 31. |
- Hou, Meijun, et al.
(författare)
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Human dopaminergic system in the exercise-cognition link
- 2024
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Ingår i: Trends in Molecular Medicine. - : Elsevier. - 1471-4914 .- 1471-499X.
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Tidskriftsartikel (refereegranskat)abstract
- While the dopaminergic system is important for cognitive processes, it is also sensitive to the influence of physical activity (PA). We summarize current evidence on whether PA-related changes in the human dopaminergic system are associated with alterations in cognitive performance, discuss recent advances, and highlight challenges and opportunities for future research.
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| 32. |
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| 33. |
- Kattge, Jens, et al.
(författare)
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TRY plant trait database - enhanced coverage and open access
- 2020
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Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Tidskriftsartikel (refereegranskat)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 34. |
- Kristan, Matej, et al.
(författare)
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The Visual Object Tracking VOT2017 challenge results
- 2017
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Ingår i: 2017 IEEE INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2017). - : IEEE. - 9781538610343 ; , s. 1949-1972
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2017 is the fifth annual tracker benchmarking activity organized by the VOT initiative. Results of 51 trackers are presented; many are state-of-the-art published at major computer vision conferences or journals in recent years. The evaluation included the standard VOT and other popular methodologies and a new "real-time" experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The VOT2017 goes beyond its predecessors by (i) improving the VOT public dataset and introducing a separate VOT2017 sequestered dataset, (ii) introducing a realtime tracking experiment and (iii) releasing a redesigned toolkit that supports complex experiments. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 35. |
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| 36. |
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| 37. |
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| 38. |
- Wang, Kai, et al.
(författare)
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Benchmarking Atomic Data for Astrophysics : Be-like Ions between B II and Ne VII
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : Institute of Physics (IOP). - 0067-0049 .- 1538-4365. ; 234:2
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Tidskriftsartikel (refereegranskat)abstract
- Large-scale self-consistent multiconfiguration Dirac-Hartree-Fock and relativistic configuration interaction calculations are reported for the n <= 6 levels in Be-like ions from B II to Ne VII. Effects from electron correlation are taken into account by means of large expansions in terms of a basis of configuration state functions, and a complete and accurate data set of excitation energies; lifetimes; wavelengths; electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole line strengths; transition rates; and oscillator strengths for these levels is provided for each ion. Comparisons are made with available experimental and theoretical results. The uncertainty of excitation energies is assessed to be 0.01% on average, which makes it possible to find and rule out misidentifications and aid new line identifications involving high-lying levels in astrophysical spectra. The complete data set is also useful for modeling and diagnosing astrophysical plasmas.
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| 39. |
- Wang, Kai, et al.
(författare)
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Calculations with spectroscopic accuracy : Energies and transition rates in the nitrogen isoelectronic sequence from Ar XII to Zn XXIV
- 2016
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Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 223:1
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Tidskriftsartikel (refereegranskat)abstract
- Combined relativistic configuration interaction and many-body perturbation calculations are performed for the 359 fine-structure levels of the 2s2 2p3, 2 s2p4, 2p5, 2s2 2p2 3l, 2 s2p3 3l, 2p4 3l, and 2s2 2p2 4l configurations in N-like ions from Ar XII to Zn XXIV. Complete and consistent data sets of energies, wavelengths, radiative rates, oscillator strengths, and line strengths for all possible electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole transitions among the 359 levels are given for each ion. The present work significantly increases the amount of accurate data for ions in the nitrogen-like sequence, and the accuracy of the energy levels is high enough to enable the identification and interpretation of observed spectra involving the n=3, 4 levels, for which experimental values are largely scarce. Meanwhile, the results should be of great help for modeling and diagnosing astrophysical and fusion plasmas.
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| 40. |
- Wang, Kai, et al.
(författare)
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EXTENDED RELATIVISTIC CONFIGURATION INTERACTION AND MANY-BODY PERTURBATION CALCULATIONS OF SPECTROSCOPIC DATA FOR THE N 6 CONFIGURATIONS IN Ne-LIKE IONS BETWEEN Cr XV AND Kr XXVII
- 2016
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Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 226:2
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Tidskriftsartikel (refereegranskat)abstract
- Level energies, wavelengths, electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole transition rates, oscillator strengths, and line strengths from combined relativistic con guration interaction and many-body perturbation calculations are reported for the 201 ne-structure states of the 2s22p6, 2s22p53l, 2s2p63l, 2s22p54l, 2s2p64l, 2s22p55l, and 2s22p56l con gurations in all Ne-like ions between Cr XV and Kr XXVII. Calculated level energies and transition data are compared with experiments from the National Institute of Standards and Technology (NIST) and CHIANTI databases, and other recent benchmark calculations. The mean energy difference with the NIST experiments is only 0.05%. The present calculations signi cantly increase the amount of accurate spectroscopic data for the n > 3 states in a number of Ne-like ions of astrophysical interest. A complete data set should be helpful for analyzing new observations from solar and other astrophysical sources, and is also likely to be useful for modeling and diagnosing a variety of plasmas, including astronomical and fusion plasma.
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| 41. |
- Yang, Tao, et al.
(författare)
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A spatial assessment of hydrologic alteration caused by dam construction in the middle and lower Yellow River, China
- 2008
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 22:18, s. 3829-3843
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Tidskriftsartikel (refereegranskat)abstract
- The ‘range of variability approach’ (RVA) and mapping technique are used to investigate the spatial variability of hydrologic alterations (HA) due to dam construction along the middle and lower Yellow River, China, over the past live decades. The impacts of climate variability oil hydrological process have been removed during wet and dry periods and the focus IS Oil the impacts of human activities, Such as dam construction, on hydrological processes. Results indicate the following: (1) The impacts of the Sanmenxia reservoir oil the hydrologic alteration are relatively slight with a mean HA value of 0.48, ranking in the last place among the four large reservoirs. (2) Xiaolangdi reservoir has significantly changed the natural flow regime downstream with mean HA value of 0.56, ranking it in first place among the large reservoirs. (3) The results of ranked median degrees of 33 hydrologic alteration indicators for 10 stations in the Yellow River show that the hydrologic alteration of Huayuankou ranks the highest among 10 stream gauges. (4) Impacts of reservoirs on hydrological processes downstream of the dams are closely associated with the regulating activities of the reservoirs. At the same time, alterations of streamflow regimes resulting from climatic changes (e.g. precipitation variability) make the situation more complicated and more hydrological observations will be necessary for further analysis. The results of the current study will be greatly beneficial to the regional water resources management and restoration of eco-environmental systems in the middle and lower Yellow River characterized by intensified dam construction under a changing environment. Copyright (C) 2008 John Wiley & Sons, Ltd.
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| 42. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 43. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 44. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 45. |
- Aktas, Özge, et al.
(författare)
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Single-particle structures in 85,87Ge
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X.
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Tidskriftsartikel (refereegranskat)abstract
- Gamma-ray transitions have been identified for the first time in the extremely neutron-rich (N =Z + 25) nucleus 87 Ge following nucleon knockout reactions studied at the RIBF, RIKEN, Japan.New γ-ray transitions from excited states in 85 Ge were also observed and placed in a tentative levelscheme. The exclusive parallel momentum distribution was measured for the 1/2 + state for theneutron knockout reaction leading to 85 Ge which is compared with calculated distorted wave impulseapproximation (DWIA) distributions. The 85,87 Ge results are compared with large-scale shell-modelcalculations and potential energy surface calculations based on the total Routhian surface formalism.
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| 46. |
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| 47. |
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| 48. |
- Baranasic, D, et al.
(författare)
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Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
- 2022
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:7, s. 1037-
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Tidskriftsartikel (refereegranskat)abstract
- Zebrafish, a popular organism for studying embryonic development and for modeling human diseases, has so far lacked a systematic functional annotation program akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created a central repository to store and process zebrafish developmental functional genomic data. Our data coordination center (https://danio-code.zfin.org) combines a total of 1,802 sets of unpublished and re-analyzed published genomic data, which we used to improve existing annotations and show its utility in experimental design. We identified over 140,000 cis-regulatory elements throughout development, including classes with distinct features dependent on their activity in time and space. We delineated the distinct distance topology and chromatin features between regulatory elements active during zygotic genome activation and those active during organogenesis. Finally, we matched regulatory elements and epigenomic landscapes between zebrafish and mouse and predicted functional relationships between them beyond sequence similarity, thus extending the utility of zebrafish developmental genomics to mammals.
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| 49. |
- Bethlehem, RAI, et al.
(författare)
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Brain charts for the human lifespan
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 604:79057906, s. 525-
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Tidskriftsartikel (refereegranskat)abstract
- Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
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| 50. |
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