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Sökning: WFRF:(Chen Zhuo)

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3.
  • Block, Keith I., et al. (författare)
  • Designing a broad-spectrum integrative approach for cancer prevention and treatment
  • 2015
  • Ingår i: Seminars in Cancer Biology. - : Academic Press. - 1044-579X .- 1096-3650. ; 35, s. S276-S304
  • Forskningsöversikt (refereegranskat)abstract
    • Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. (C) 2015 The Authors. Published by Elsevier Ltd.
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4.
  • Bai, Fan, et al. (författare)
  • Application of similarity theory in modeling the output characteristics of proton exchange membrane fuel cell
  • 2021
  • Ingår i: International journal of hydrogen energy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0360-3199 .- 1879-3487. ; 46:74, s. 36940-36953
  • Tidskriftsartikel (refereegranskat)abstract
    • Proton Exchange Membrane Fuel Cell (PEMFC) has attracted widespread interest. In the present work, similarity analysis is adopted for a three-dimensional single-phase isothermal model of PEMFC to derive similarity criteria. Seven kinds of input criteria (Pi(1) similar to Pi(7)) are obtained, relevant to the fluid flow, pressure drop, flow resistance in a porous medium, activity loss, diffusion mass transfer, convective mass transfer and ohmic loss in PEMFC respectively. Dimensionless voltage and dimensionless current density are defined as two output criteria. Numerical verifications show that if the seven criteria keep their individual values with their components vary in a wide range, the dimensionless polarization curves keep the same with a deviation about 1%, showing the validity and feasibility of the present analysis. From the effect on the dimensionless polarization curve, sensibility analysis shows that the seven criteria can be divided into three categories: strong (Pi(4) and Pi(7), -94.9% similar to +349.2%), mild to minor (Pi(5) and Pi(6), -4.5% similar to +5.0%), and negligible (Pi(1), Pi(2) and Pi(3), -1.2% similar to +1.1%). The similarity analysis approach can greatly save computation time in modeling the output characteristics of PEMFC. (C) 2021 Published by Elsevier Ltd on behalf of Hydrogen Energy Publications LLC.
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5.
  • Ma, Tao, et al. (författare)
  • Genomic insights into salt adaptation in a desert poplar
  • 2013
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4, s. 2797-
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite the high economic and ecological importance of forests, our knowledge of the genomic evolution of trees under salt stress remains very limited. Here we report the genome sequence of the desert poplar, Populus euphratica, which exhibits high tolerance to salt stress. Its genome is very similar and collinear to that of the closely related mesophytic congener, P. trichocarpa. However, we find that several gene families likely to be involved in tolerance to salt stress contain significantly more gene copies within the P. euphratica lineage. Furthermore, genes showing evidence of positive selection are significantly enriched in functional categories related to salt stress. Some of these genes, and others within the same categories, are significantly upregulated under salt stress relative to their expression in another salt-sensitive poplar. Our results provide an important background for understanding tree adaptation to salt stress and facilitating the genetic improvement of cultivated poplars for saline soils.
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6.
  • Ma, Wenjun, et al. (författare)
  • Responses of soil extracellular enzyme activities and microbial community properties to interaction between nitrogen addition and increased precipitation in a semi-arid grassland ecosystem
  • 2020
  • Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 703
  • Tidskriftsartikel (refereegranskat)abstract
    • Both atmospheric nitrogen (N) deposition and precipitation can strongly impact below-ground biogeochemical processes. Soil extracellular enzymes activities (EEAs) and microorganisms are considered as the key agents in ecosystem nutrient cycling. However, how the interaction between increasing N deposition and precipitation may affect soil EEAs and microbes remain poorly understood. In a 5-year field experiment in a meadow steppe in northern China, we tested the effects of N addition (N0, 0; N1, 5; N2, 10 g N m−2 yr−1) and increased precipitation (W0, ambient precipitation; W1, increase of 15% ambient precipitation; W2, increase of 30% ambient precipitation) on soil EEAs, microbial and chemical properties. Results showed that their interaction significantly affected all hydrolase activities, except for β-1,4-xylosidase (βX). Furthermore, increased precipitation and N addition interactively affected bacterial gene copies (P ≤ 0.05), and increased precipitation comparatively had a stronger effects. The results on the combination of N addition and increased precipitation showed that increased precipitation alleviated the positive effects of N addition on soil EEAs. This implies that the effects of either treatment alone on grassland biogeochemical processes may be alleviated by their simultaneous occurrence. Our results suggested that soil EEAs were mainly controlled by the content of N and phosphorus (P), and the ratio of C: N and C: P. Therefore, soil element content and stoichiometry could better explain the responses of EEAs to global changes. Moreover, soil microbial communities were mainly controlled by soil P content. Overall, our study highlights that the interaction between N deposition and precipitation may play a vital role in predicting the responses of soil enzyme activities to global changes in grassland ecosystems.
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7.
  • Menkveld, Albert J., et al. (författare)
  • Nonstandard Errors
  • 2024
  • Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
  • Tidskriftsartikel (refereegranskat)abstract
    • In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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8.
  • Zhang, Zhuo, et al. (författare)
  • Demonstration of three‐dimensional indoor visible light positioning with multiple photodiodes and reinforcement learning
  • 2020
  • Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 20:22, s. 1-14
  • Tidskriftsartikel (refereegranskat)abstract
    • To provide high‐quality location‐based services in the era of the Internet of Things, visible light positioning (VLP) is considered a promising technology for indoor positioning. In this paper, we study a multi‐photodiodes (multi‐PDs) three‐dimensional (3D) indoor VLP system enhanced by reinforcement learning (RL), which can realize accurate positioning in the 3D space without any off-line training. The basic 3D positioning model is introduced, where without height information of the receiver, the initial height value is first estimated by exploring its relationship with the received signal strength (RSS), and then, the coordinates of the other two dimensions (i.e., X and Y in the horizontal plane) are calculated via trilateration based on the RSS. Two different RL processes, namely RL1 and RL2, are devised to form two methods that further improve horizontal and vertical positioning accuracy, respectively. A combination of RL1 and RL2 as the third proposed method enhances the overall 3D positioning accuracy. The positioning performance of the four presented 3D positioning methods, including the basic model without RL (i.e., Benchmark) and three RL based methods that run on top of the basic model, is evaluated experimentally. Experimental results verify that obviously higher 3D positioning accuracy is achieved by implementing any proposed RL based methods compared with the benchmark. The best performance is obtained when using the third RL based method that runs RL2 and RL1 sequentially. For the testbed that emulates a typical office environment with a height difference between the receiver and the transmitter ranging from 140 cm to 200 cm, an average 3D positioning error of 2.6 cm is reached by the best RL method, demonstrating at least 20% improvement compared to the basic model without performing RL.
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  • Zhang, Zhuo, et al. (författare)
  • Iterative point-wise reinforcement learning for highly accurate indoor visible light positioning
  • 2019
  • Ingår i: Optics Express. - : OPTICAL SOC AMER. - 1094-4087 .- 1094-4087. ; 27:16, s. 22161-22172
  • Tidskriftsartikel (refereegranskat)abstract
    • Iterative point-wise reinforcement learning (IPWRL) is proposed for highly accurate indoor visible light positioning (VLP). By properly updating the height information in an iterative fashion, the IPWRL not only effectively mitigates the impact of non-deterministic noise but also exhibits excellent tolerance to deterministic errors caused by the inaccurate a priori height information. The principle of the IPWRL is explained, and the performance of the IPWRL is experimentally evaluated in a received signal strength (RSS) based VLP system and compared with other positioning algorithms, including the conventional RSS algorithm, the k-nearest neighbors (KNN) algorithm and the PWRL algorithm where iterations exclude. Unlike the supervised machine learning method, e.g., the KNN, whose performance is highly dependent on the training process, the proposed IPWRL does not require training and demonstrates robust positioning performance for the entire tested area. Experimental results also show that when a large height information mismatch occurs, the IPWRL is able to first correct the height information and then offers robust positioning results with a rather low positioning error, while the positioning errors caused by the other algorithms are significantly higher.
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10.
  • Chen, Zhuo, et al. (författare)
  • Large mechanical properties enhancement in ceramics through vacancy-mediated unit cell disturbance
  • 2023
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Tailoring vacancies is a feasible way to improve the mechanical properties of ceramics. However, high concentrations of vacancies usually compromise the strength (or hardness). We show that a high elasticity and flexural strength could be achieved simultaneously using a nitride superlattice architecture with disordered anion vacancies up to 50%. Enhanced mechanical properties primarily result from a distinctive deformation mechanism in superlattice ceramics, i.e., unit-cell disturbances. Such a disturbance substantially relieves local high-stress concentration, thus enhancing deformability. No dislocation activity involved also rationalizes its high strength. The work renders a unique understanding of the deformation and strengthening/toughening mechanism in nitride ceramics.
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11.
  • Chen, Zhuo, et al. (författare)
  • Reliability-Oriented Multi-Objective Optimization of Electrical Machines Considering Insulation Thermal Lifetime Prediction
  • 2024
  • Ingår i: IEEE Transactions on Transportation Electrification. - : Institute of Electrical and Electronics Engineers (IEEE). - 2332-7782. ; 10:1, s. 2264-2276
  • Tidskriftsartikel (refereegranskat)abstract
    • With the trend toward transportation electrification, the power density of electrical machines faces ever-increasing requirement owing to the stringent limit of weight, especially for aerospace applications. Conventionally, the reliability of electrical machines in such safety-critical application is guaranteed by considerable safety margins, i.e., the over-engineering approach, which prevents electrical machines from reaching higher power densities and leads to a design conflict. This paper proposes a reliability-oriented design approach for low-voltage electrical machines by integrating model-based lifetime prediction into a multi-objective optimization process. Accelerated thermal degradation tests are carried out on mainwall insulation and turn insulation, then the thermal degradation model is built to predict the lifetimes, accordingly. Thermal lifetime models are developed at several lifetime percentiles for both continuous duty and variable duty applications. Finally, a feasible reliability-oriented multi-objective optimization platform is established, based on which a study-case electrical machine for aerospace application is designed and optimized. The prototype is manufactured to verify the optimized performances.
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12.
  • Chen, Zhuo Yuan, et al. (författare)
  • Effect of carbon dioxide on sodium chloride-induced atmospheric corrosion of copper
  • 2005
  • Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 0013-4651 .- 1945-7111. ; 152:12, s. B502-B511
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of carbon dioxide (CO2) on sodium chloride (NaCl) induced atmospheric corrosion of copper was studied in laboratory exposures using microgravimetry, ion chromatography, Fourier transform infrared spectroscopy, and scanning electron microscopy with X-ray microanalysis. With lower amount of NaCl particles on the copper surface (< 15 mu g/cm(2)), the corrosion rate was higher with < 1 ppm CO2 than with 350 ppm CO2, and for higher amount of NaCl (> 15 mu g/cm(2)), the corrosion was higher with 350 ppm CO2. With lower amount of NaCl and low CO2 concentration, a secondary spreading of electrolyte occurred from the droplets that formed at the particle clusters. This led to a larger effective cathodic area and a higher corrosion rate. However, at higher surface concentration of NaCl a spatial interaction effect between the local corrosion sites counteracted the increase in the corrosion rate due to overlap of the cathodic areas from the particles. Another factor, which influenced the corrosion process, was the effect of CO2 on the pH of the surface electrolyte. Higher pH (< 1 ppm CO2 concentration) increased the formation of CuO, which improved the corrosion resistance of the corrosion product layer but hindered the formation of insoluble CuCl, whereby more soluble chloride ions were available for triggering localized corrosion and accelerating the initial atmospheric corrosion of copper. Hence, the overall influence of CO2 and NaCl depends on at least three identified mechanisms.
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  • Chen, Zhuo Yuan, et al. (författare)
  • In situ studies of the effect of CO2 on the initial NaCl-induced atmospheric corrosion of copper
  • 2005
  • Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 0013-4651 .- 1945-7111. ; 152:9, s. B342-B351
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of carbon dioxide (CO2) on the NaCl-induced atmospheric corrosion of copper was studied using in situ Fourier transform infrared microspectroscopy, in situ scanning Kelvin probe, and scanning electron microscopy/energy-dispersive analysis by X-ray. The copper surface was contaminated with a single NaCl particle and then exposed to 80 +/- 2% relative humidity clean humidified air with two concentrations of CO2 (< 5 and 350 ppm). After formation of an electrolyte droplet secondary spreading of electrolyte from the peripherical parts of the droplet was observed. The secondary spreading effect, which was much larger at < 5 ppm CO2 than at 350 ppm, was a consequence of the formation of a galvanic element between a local cathode outside the edge of the droplet and an anode in the droplet. This lead to alkaline conditions in the secondary spreading area and transport of Na+ ions to the local cathode. The large secondary spreading at low CO2 concentration was possible due to lowering of the surface tension of the electrolyte/metal oxide interface at the peripheral parts of the droplet. Carbonate formation lowered the pH when the CO2 concentration was 350 ppm and resulted in a decrease of the pH and inhibition of the secondary spreading.
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14.
  • Chen, Zhuo Yuan, et al. (författare)
  • In situ studies of the effect of SO2 on the initial NaCl-induced atmospheric corrosion of copper
  • 2005
  • Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 0013-4651 .- 1945-7111. ; 152:12, s. B526-B533
  • Tidskriftsartikel (refereegranskat)abstract
    • The initial SO2-induced atmospheric corrosion of copper deposited with NaCl has been examined with Fourier transform infrared microspectroscopy under in situ and ex situ conditions in order to reveal the spatial distribution of reaction products. The oxidation of S(IV) turns out to be fast at the area of the NaCl-containing electrolyte droplet, and both sulfate (SO42-) and dithionate (S2O62-) ions form. A copper-catalyzed reaction route for the sulfite oxidation has been suggested, which includes the formation of a Cu(II)-sulfito complex as an important step. The presence of gaseous oxidants such as NO2 and O-3 has previously been considered as an important prerequisite for the oxidation of sulfite on copper. The results obtained here suggest that the formation of local electrochemical cells induced by deposited NaCl particles could be another important route for S(IV) oxidation to sulfate formation. SO2 was found to promote the formation of less soluble paratacamite [Cu-2(OH)(3)Cl] and nantokite (CuCl), which may slow down the atmospheric corrosion rate of copper.
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  • Chen, Zhuo Yuan, et al. (författare)
  • Initial NaCl- Particle Induced Atmospheric Corrosion of Zinc-Effect of CO2 and SO2
  • 2008
  • Ingår i: Corrosion Science. - : Elsevier BV. - 0010-938X .- 1879-0496. ; 50:1, s. 111-123
  • Tidskriftsartikel (refereegranskat)abstract
    • Initial corrosion and secondary spreading effects during NaCl particle induced corrosion on zinc was explored using in situ and ex situ FTIR microspectroscopy, optical microscopy, and SEM/EDAX. The secondary spreading effect which occurs upon introduction of humid air on NaCl deposited zinc surfaces was strongly dependent on the CO2 and SO2 content of the introduced air. Ambient level of CO2 (350 ppm) resulted in a relatively low spreading effect, whereas the lower level of CO2 (<5 ppm) caused a much faster spreading over a larger area. In the presence of SO2, the secondary spreading effect was absent which could limit the cathodic process in this case. At <5 ppm CO2, the corrosion is more localized, with the formation of simonkolleite (Zn5(OH)8Cl2 · H2O), zincite (ZnO) and sodium carbonate (Na2CO3), and a larger effective cathodic area. At 350 ppm CO2, the corrosion is more general and formation of simonkolleite, hydrozincite (Zn5(OH)6(CO3)2) and sodium carbonate was observed. Sodium carbonate was mainly formed in more alkaline areas, in the inner edge of the electrolyte droplet and in the secondary spreading area. Oxidation of sulphur and concomitant sulphate formation was enhanced in the presence of NaCl particles, due to the formation of a droplet, the separation of the anodic and cathodic areas and the accompanying differences in chemical composition and pH in the surface electrolyte.
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17.
  • Chen, Zhuo Yuan, et al. (författare)
  • The Combined Effects of Gaseous pollutants and Sodium Chloride Particles on the Atmospheric Corrosion of Pure Copper
  • 2005
  • Ingår i: Corrosion. - : NACE International. - 0010-9312 .- 1938-159X. ; 61:11, s. 1022-1034
  • Tidskriftsartikel (refereegranskat)abstract
    • The atmospheric corrosion of pure copper has been investigated after the deposition of sodium chloride (NaCI) particles and exposure to humid air containing gaseous pollutants. Microgravimetry, Fourier transform infrared (FTIR) micro-spectroscopy, and scanning electron microscopy with x-ray microanalysis were used for the investigation of corrosion processes and products. The effect of NaCl particles on the mass gain was much higher than that of gaseous pollutants. With deposition of NaCl particles on the copper surfaces, the corrosion rate increased significantly, with severe corrosion attack mainly localized to the NaCl particle clusters. A similar corrosion rate was found, however, after exposure to pure humid air and to humid air containing gaseous pollutants, sulfur dioxide (SO2), ozone (O-3), nitrogen dioxide (NO2), and SO2 + NO2. The corrosion rate was not dependent on the concentration of the pollutants. However, this was not the case for the combination of SO2 and O-3, leading to a significantly higher corrosion rate at higher concentrations. Exposure of copper samples with NaCl particles deposited resulted in unevenly distributed corrosion product clusters, with a distribution of corrosion products that could be associated with the locations of the particle clusters. Around the particle clusters, the corrosion resulted in areas with different amounts of corrosion products. After 10 days of exposure to humid air containing 100 ppb SO2 and 100 ppb NO2 + SO2, cuprite (Cu2O), paratacamite (Cu-2[OH](3)Cl), carbonate (CO32-), and sulfate (SO42-) were observed mainly in the area of the original particle cluster, with some sutfate and copper hydroxysulfate also in the areas outside. After 10 days of exposure to humid air containing 100 ppb O-3 + SO2, cuprite (Cu2O), hydroxychloride (maybe paratacamite, Cu-2[OH](3)Cl), carbonate (CO32-), and sutfate (SO42-) were observed in the area of the original particle cluster. A circular zone containing brochantite (Cu-4[OH](6)SO4) was formed around and outside of the original particle cluster, and the formation of this phase was promoted by the presence of NaCl particles on the surface. The location of anodic and cathodic reactions during the corrosion process leads to the distribution of different corrosion products on the surface.
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19.
  • Chen, Zhuo Yuan, et al. (författare)
  • The Effect of Sodium Chloride Particles on the Atmospheric Corrosion of Pure Copper
  • 2004
  • Ingår i: Corrosion. - : NACE International. - 0010-9312 .- 1938-159X. ; 60:5, s. 479-491
  • Tidskriftsartikel (refereegranskat)abstract
    • The atmospheric corrosion of copper has been investigated after deposition of sodium chloride (NaCl) particles and 10 days of subsequent exposure to clean, humidified air below, near, and above the point of deliquescence of NaCl (at around 75% relative humidity (RH), Microgravimetry, Fourier transform infrared (FTIR) microspectroscopy, scanning electron microscopy with x-ray microanalysis, and scanning Kelvin probe were used to identify corrosion processes and products. The NaCl deposition resulted in the evenly distributed NaCl particle clusters with a diameter of approximately 100 μm. The clusters consisted of individual NaCl particles of <10 μm. The mass gain increased linearly with the amount of NaCl particles added in the range of this study (up to 4 μg/cm2). Even at very low RH (55%), which lies far below the point of deliquescence (75%), copper with NaCl particles added suffered from significant corrosion attack and the mass gain of copper with 4 μg/cm2 NaCl added was about 7 μg/cm2 after 10 days of exposure. At 55% RH, the NaCl particles did not dissolve. However, significant chloride-induced corrosion effects were observed after 10 days, both in the original particle cluster and in a 20-μm-wide outer zone into which chloride ions had dffused radially. At 75% RH, the NaCl particles dissolved and chloride ions diffused to cover the whole surface. Chloride-accelerated corrosion effects resulted in the formation of cuprite (Cu2O) and copper carbonate, mainly in the area of the original particle cluster. The corrosion effects accelerated further at 95% PH, resulting in the formation of Cu2O over the whole surface and copper carbonate in a concentric zone outside the original particle cluster. The distribution of the corrosion products was related to the localization of the anodic and cathodic reactions during the corrosion process.
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  • Chen, Zhuo Yuan, 1970- (författare)
  • The role of particles on initial atmospheric corrosion of copper and zinc : lateral distribution, secondary spreading and CO2-/SO2-influence
  • 2005
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The role of sodium chloride (NaCl) particles and ammonium sulfate ((NH4)2SO4) particles on the initial atmospheric corrosion of copper and zinc was investigated under in situ and ex situ conditions using microgravimetry, FTIR spectroscopy, ion chromatography, scanning electron microscopy with x-ray microanalysis and the scanning Kelvin probe. For the first time, in situ infrared spectra were collected on a micron level during particle induced atmospheric corrosion using a recently developed experimental set-up for in situ FTIR microspectroscopy. Lateral distribution of corrosion and reaction products on copper and zinc surfaces was determined and could be connected with the mechanisms of the initial particle induced corrosion. The recently discovered secondary spreading effect from NaCl electrolyte droplets on metal surfaces was studied under in situ conditions and the effect of CO2 on the spreading process was elaborated. The ambient level of CO2 (350 ppm, 1 ppm = 10-6 volume parts) results in a relatively low secondary spreading effect, whereas the lower level of CO2 (<5 ppm) causes a much faster secondary spreading effect over a large area. At low CO2 concentration alkaline conditions will prevail in the cathodic area, leading to large changes in the surface tension at the oxide/electrolyte interface in the peripherical parts of the droplet. This induces a surface tension driven convective flow of electrolyte from the NaCl droplet. The continuous growth of the secondary spreading area at low CO2 concentration is possible due to the galvanic coupling with the droplet leading to transport of sodium ions to this region and maintenance of the alkaline conditions. At 350 ppm CO2, carbonate formation in the secondary spreading area results in lowering of the pH, increasing the surface tension of the oxide/electrolyte interface and inhibiting the secondary spreading. CO2 strongly affects the NaCl-induced atmospheric corrosion rate of copper. The overall influence of CO2 and NaCl depends on at least three identified mechanisms. At low NaCl particle density, CO2 affects the secondary spreading effect from the electrolyte droplet. This leads to a larger effective cathodic area at low CO2 concentration and a higher corrosion rate. The more alkaline surface electrolyte present at low CO2 concentration also affects the formation of corrosion products and the amount of soluble copper chloride. Whereas the presence of larger amounts of soluble chloride tends to increase the corrosion rate, the formation of CuO results in a more protective surface film which decreases the corrosion rate. This effect was observed at higher NaCl particle densities, where the secondary spreading areas overlapped with adjacent NaCl particle clusters. The formation of CuO leads to lower corrosion rates compared to ambient CO2 concentration in which this phase was not formed. For zinc, the formation of a more protective corrosion product layer was not observed and the corrosion rate is generally higher for low than for ambient CO2 concentration. The presence of NaCl particles on the metal surfaces strongly affects the SO2 interaction with the metal surfaces. The oxidation of S(IV) turned out to be fast at the area of the NaCl-containing electrolyte droplet, both for copper and zinc. On copper surfaces, both sulphate (SO4 2-) and dithionate (S2O6 2-) ions formed which is consistent with a copper catalysed reaction route for sulfite oxidation including the formation of a Cu(II)–sulfito complex as an important step. For zinc, a surface mediated sulfite oxidation process leads to rapid formation of sulphate in the electrolyte droplet area. The presence of SO2 strongly inhibits the secondary spreading due to the decrease in pH induced by absorption of SO2 in the cathodic areas. The presence of gaseous oxidants, such as NO2 and O3, has previously been considered as an important prerequisite for the oxidation of sulfite on copper. The results obtained here suggest that the formation of local electrochemical cells induced by deposited NaCl particles could be another important route for S(IV)- oxidation to sulfate formation. On copper, SO2 was also found to promote the formation of less soluble copper chlorides, such as paratacamite (Cu2(OH)3Cl) and nantokite (CuCl). The electrolyte droplet was dried after 24 hours of exposure due to the formation of less soluble paratacamite (Cu2(OH)3Cl) and nantokite (CuCl) and led to a decrease in the corrosion rate. Thus, SO2 alone promotes the corrosion rate of copper, whereas in the presence of NaCl particles the corrosion rate of copper may slow down due to the formation of insoluble copper chloride compounds. The lateral distribution of corrosion products after exposure of NaCl contaminated copper and zinc surfaces to humid air with gaseous pollutants is a result of the formation of local electrochemical cells at the particles and concomitant differences in chemical composition and pH. For (NH4)2SO4 deposited copper and zinc surfaces the corrosion effects increase with the amount of pre-deposited particles and with the exposure time. On copper, the size of the particles affects the corrosion rate, smaller particles resulting in a higher corrosion rate than larger particles at equal amount of deposition. The formation of Cu2O was the dominant corrosion product after exposure longer than 10 days. (NH4)2SO4 particles result in enhanced Cu2O formation on copper due to a reaction sequence involving catalysis by NH3. The corrosion of copper by (NH4)2SO4 particles was much larger than that induced by NaCl particles. However, for zinc, the (NH4)2SO4 particles lead to smaller corrosion effects than those of NaCl particles. For both particles, significant corrosion attack was observed at relative humidity (RH) lower than the deliquescence point of the salts.
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21.
  • Cheng, Yirui, et al. (författare)
  • NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation
  • 2023
  • Ingår i: Protein & Cell. - : Springer Nature. - 1674-800X .- 1674-8018. ; 14:2, s. 123-136
  • Tidskriftsartikel (refereegranskat)abstract
    • NDFIP1 has been previously reported as a tumor suppressor in multiple solid tumors, but the function of NDFIP1 in NSCLC and the underlying mechanism are still unknown. Besides, the WW domain containing proteins can be recognized by NDFIP1, resulted in the loading of the target proteins into exosomes. However, whether WW domain-containing transcription regulator 1 (WWTR1, also known as TAZ) can be packaged into exosomes by NDFIP1 and if so, whether the release of this oncogenic protein via exosomes has an effect on tumor development has not been investigated to any extent. Here, we first found that NDFIP1 was low expressed in NSCLC samples and cell lines, which is associated with shorter OS. Then, we confirmed the interaction between TAZ and NDFIP1, and the existence of TAZ in exosomes, which requires NDFIP1. Critically, knockout of NDFIP1 led to TAZ accumulation with no change in its mRNA level and degradation rate. And the cellular TAZ level could be altered by exosome secretion. Furthermore, NDFIP1 inhibited proliferation in vitro and in vivo, and silencing TAZ eliminated the increase of proliferation caused by NDFIP1 knockout. Moreover, TAZ was negatively correlated with NDFIP1 in subcutaneous xenograft model and clinical samples, and the serum exosomal TAZ level was lower in NSCLC patients. In summary, our data uncover a new tumor suppressor, NDFIP1 in NSCLC, and a new exosome-related regulatory mechanism of TAZ.
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22.
  • Ding, Chen, et al. (författare)
  • An Ultra-Low Latency Multicast Router for Large-Scale Multi-Chip Neuromorphic Processing
  • 2021
  • Ingår i: 2021 IEEE 3rd international conference on artificial intelligence circuits and systems (AICASs). - : Institute of Electrical and Electronics Engineers (IEEE).
  • Konferensbidrag (refereegranskat)abstract
    • Neuromorphic simulation is fundamental to the study of information processing mechanism of the human brain and can further inspire application development of event-driven spiking neural networks. However large-scale neuromorphic simulation requires massive parallelism on multi-chip processing and imposes great challenges on dealing with data transmission latency and congestion problems between chips, especially when the number of simulated neurons reaches to billions or even trillions level. In this paper, we propose an ultra-low-latency on-chip router together with a multicast routing algorithm that focuses on reducing global loads and balancing loads between links. Additionally, we build a large-scale neuromorphic simulation platform consisting of 64 FPGA chips and evaluate the proposed design on it. The experiment results suggest that this design benefits from the proposed multicast routing algorithm in global communication loads and simulation capacity. This work has 4.1% similar to 5.2% reduction of global loads comparing to previous works and can achieve a latency as low as 25ns and a maximum data throughput of 6.25Gbps/chip.
  •  
23.
  • Driouchi, Tarik, et al. (författare)
  • Ambiguity, Managerial Ability, and Growth Options
  • 2022
  • Ingår i: British Journal of Management. - : Wiley. - 1045-3172 .- 1467-8551. ; 33:3, s. 1323-1345
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper studies the role of ambiguity and managerial ability in firm growth options from the perspective of behavioural theory. We argue that managerial ability increases both the identification and exploitation of growth options opportunities, but ambiguity reduces strategic growth options value as a result of information incompleteness and non-Bayesian behaviour. Using a dataset of all US-listed firms, we test the joint effects of ambiguity and managerial ability on growth options value after controlling for standard determinants and endogeneity. The results indicate that ambiguity has a negative effect on growth options value, while ability has a positive effect. We also find that the negative association between ambiguity and growth options is less pronounced with higher managerial ability. These findings underscore the importance of firm heterogeneity in the identification, exercise, and management of strategic and innovative real options opportunities. The paper's contribution provides relevant management insights into the behavioural antecedents of real options at the firm level as well as highlights that managerial and behavioural characteristics are important determinants of growth options value.
  •  
24.
  • Guo, Wei, et al. (författare)
  • Highly efficient dye-sensitized solar cells based on nitrogen-doped titania with excellent stability
  • 2011
  • Ingår i: Journal of Photochemistry and Photobiology A. - : Elsevier BV. - 1010-6030 .- 1873-2666. ; 219:2-3, s. 180-187
  • Tidskriftsartikel (refereegranskat)abstract
    • A series of nitrogen-doped and undoped TiO2 nanocrystals was prepared by several simple methods. Needle-like N-doped TiO2 nanocrystals and nanoparticles were obtained from commercial TiO2 powders. Several dye-sensitized solar cells (DSCs) were fabricated based on N-doped and undoped TiO2 electrodes. The N-doped DSCs achieved a high conversion efficiency of 10.1% and 4.8% using an organic electrolyte and an ionic liquid electrolyte, respectively. Systemic investigations were carried out on the properties of N-doped and undoped TiO2 powders, films, and DSCs. The electron transport time and electron lifetime were investigated by intensity-modulated photocurrent and photovoltage spectroscopy (IMPS/IMVS). Moreover, the electron injection of N-doped DSCs was studied by surface photovoltage spectroscopy (SPS). The synergetic effect of higher dye uptake, faster electron transport and higher photovoltage contributes to a higher conversion efficiency of N-doped DSCs. The stability test also demonstrated that the photodegradation of the DSCs was not accelerated and the DSC system was stabilized by the introduction of nitrogen into the TiO2 photoelectrode. These results indicate that the N-doped TiO2 nanocrystals prepared by our approach from commercial TiO2 are ideal semiconductor materials for DSCs.
  •  
25.
  • Huang, Jiayu, et al. (författare)
  • A Reconfigurable Near-Sensor Processor for Anomaly Detection in Limb Prostheses
  • 2024
  • Ingår i: IEEE Transactions on Biomedical Circuits and Systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 1932-4545 .- 1940-9990. ; , s. 1-14
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents a reconfigurable near-sensor anomaly detection processor to real-time monitor the potential anomalous behaviors of amputees with limb prostheses. The processor is low-power, low-latency, and suitable for equipment on the prostheses and comprises a reconfigurable Variational Autoencoder (VAE), a scalable Self-Organizing Map (SOM) Array, and a window-size-adjustable Markov Chain, which can implement an integrated miniaturized anomaly detection system. With the reconfigurable VAE, the proposed processor can support up to 64 sensor sampling channels programmable by global configuration, which can meet the anomaly detection requirements in different scenarios. A scalable SOM array allows for the selection of different sizes based on the complexity of the data. Unlike traditional time accumulation-based anomaly detection methods, the Markov Chain is utilized to detect time-series-based anomalous data. The processor is designed and fabricated in a UMC 40-nm LP technology with a core area of 1.49 mm2 and a power consumption of 1.81 mW. It achieves real-time detection performance with 0.933 average F1 Score for the FSP dataset within 24.22 s, and 0.956 average F1 Score for the SFDLA-12 dataset within 30.48 s, respectively. The energy dissipation of detection for each input feature is 43.84 nJ with the FSP dataset, and 55.17 nJ with the SFDLA-12 dataset. Compared with ARM Cortex-M4 and ARM Cortex-M33 microcontrollers, the processor achieves energy and area efficiency improvements ranging from 257×, 193× and 11×, 8×, respectively. IEEE
  •  
26.
  • Janknecht, Rebecca, et al. (författare)
  • A Strategy to Enhance the B-Solubility and Mechanical Properties of Ti-B-N Thin Films
  • 2024
  • Ingår i: Acta Materialia. - : Elsevier. - 1359-6454 .- 1873-2453. ; 271
  • Tidskriftsartikel (refereegranskat)abstract
    • The Ti–B–N system offers a wide range of possible meta(stable) phases, making it interesting for science and industry. However, the solubility for B within the face-centered cubic (fcc)-TiN lattice is rather limited and less studied, especially without forming B-rich phases. Therefore, we address how chemistries along the TiN–TiB2 or TiN–TiB tie-line influence this B-solubility. The variation between these two tie-lines is realized through non-reactive co-sputtering of a TiN, TiB2, and Ti target. We show that for variations along the TiN–TiB tie-line, even 8.9 at.% B (equivalent to 19.3 at.% non-metal fractions) can fully be incorporated into the fcc-TiNy lattice without forming other B-containing phases. The combination of detailed microstructural characterization through X-ray diffraction and transmission electron microscopy with ab initio calculations of fcc-Ti1-xNBx, fcc-TiN1-xBx, and fcc-TiN1-2xBx solid solutions indicates that B essentially substitutes N.The single-phase fcc-TiB0.17N0.69 (the highest B-containing sample along the TiN–TiB tie-line studied) exhibits the highest hardness H of 37.1±1.9 GPa combined with the highest fracture toughness KIC of 3.0±0.2 MPa·m1/2 among the samples studied. These are markedly above those of B-free TiN0.87 having H = 29.2±2.1 GPa and KIC = 2.7±<0.1 MPa·m1/2.
  •  
27.
  • Koutna, Nikola, et al. (författare)
  • Atomistic mechanisms underlying plasticity and crack growth in ceramics : a case study of AlN/TiN superlattices
  • 2022
  • Ingår i: Acta Materialia. - : Pergamon-Elsevier Science Ltd. - 1359-6454 .- 1873-2453. ; 229
  • Tidskriftsartikel (refereegranskat)abstract
    • Interfaces between components of a material govern its mechanical strength and fracture resistance. While a great number of interfaces is present in nanolayered materials, such as superlattices, their fundamental role during mechanical loading lacks understanding. Here we combine ab initio and classical molecular dynamics simulations, nanoindentation, and transmission electron microscopy to reveal atomistic mechanisms underlying plasticity and crack growth in B1 AlN(001)/TiN(001) superlattices under loading. The system is a model for modern refractory ceramics used as protective coatings. The simulations demonstrate an anisotropic response to uniaxial tensile deformation in principal crystallographic directions due to different strain-activated plastic deformation mechanisms. Superlattices strained orthogonal to (001) interfaces show modest plasticity and cleave parallel to AlN/TiN layers. Contrarily, B1-to-B3 or B1-to-B4(B-k) phase transformations in AlN facilitate a remarkable toughness enhancement upon in plane [110] and [100] tensile elongation, respectively. We verify the predictions experimentally and conclude that strain-induced crack growth-via loss of interface coherency, dislocation-pinning at interfaces, or layer interpenetration followed by formation of slip bands-can be hindered by controlling the thicknesses of the superlattice nanolayered components.
  •  
28.
  • Li, Furong, et al. (författare)
  • Towards quantification of Holocene anthropogenic land-cover change in temperate China : A review in the light of pollen-based REVEALS reconstructions of regional plant cover
  • 2020
  • Ingår i: Earth-Science Reviews. - : Elsevier. - 0012-8252 .- 1872-6828. ; 203, s. 1-25
  • Forskningsöversikt (refereegranskat)abstract
    • In an attempt to quantify Holocene anthropogenic land-cover change in temperate China, we 1) applied the REVEALS model to estimate plant-cover change using 94 pollen records and relative pollen productivity for 27 plant taxa, 2) reviewed earlier interpretation of pollen studies in terms of climate- and human-induced vegetation change, and 3) reviewed information on past land use from archaeological studies. REVEALS achieved a more realistic reconstruction of plant-cover change than pollen percentages in terms of openland versus woodland. The study suggests successive human-induced changes in vegetation cover. The first signs of human-induced land-cover change (crop cultivation, otherwise specified) are found c. 7 ka BP in the temperate deciduous forest, and S and NE Tibetan Plateau (mainly grazing, possibly crop cultivation), 6.5-6 ka BP in the temperate steppe and temperate desert (grazing, uncertain), and 5.5-5 ka BP in the coniferous-deciduous mixed forest, NE subtropical region, and NW Tibetan Plateau (grazing). Further intensification of anthropogenic land-cover change is indicated 5-4.5 ka BP in the E temperate steppe, and S and NE Tibetan Plateau (grazing, cultivation uncertain), 3.5-3 ka BP in S and NE Tibetan Plateau, W temperate steppe, temperate desert (grazing), and NW Tibetan Plateau (probably grazing), and 2.5-2 ka BP in the temperate deciduous forest, N subtropical region, and temperate desert (grazing). These changes generally agree with increased human activity as documented by archaeological studies. REVEALS reconstructions have a stronger potential than biomization to evaluate scenarios of anthropogenic land-cover change such as HYDE, given they are combined with information from archaeological studies.
  •  
29.
  • Li, Zhaokai, et al. (författare)
  • Analytical Analysis of Quasi-Halbach Array Permanent-Magnet Motors Based on Field Separation Theory
  • 2024
  • Ingår i: IEEE Transactions on Transportation Electrification. - : Institute of Electrical and Electronics Engineers (IEEE). - 2332-7782. ; , s. 1-1
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper proposes the field separation theory for predicting the magnetic field of a quasi-Halbach array permanent-magnet motor considering the magnetization pattern and iron saturation. According to the proposed method, the air-gap field consists of a permanent-magnet field, winding current field, and equivalent saturation field. The equivalent permanent-magnet currents replacing the Halbach array with radial or parallel magnetization are introduced to obtain the linear analytical air-gap field of the permanent magnets. The winding current field relating to the slot shape and air-gap length can be directly determined using the linear analytical model. The equivalent saturation field is derived from the combination of the linear analytical model in the air gap and the magnetic circuit model in the iron region. The finite-element analysis of an 8-pole/9-slot Halbach array permanent-magnet motor and its prototype experiments are carried out to verify the effectiveness of the field separation theory, which is then used to analyze the harmonic magnetic field of Halbach array permanent-magnet motors to further improve the electromagnetic torque estimation. 
  •  
30.
  • Li, Zhaokai, et al. (författare)
  • Hybrid Analytical Model for Predicting the Electromagnetic Losses in Surface-Mounted Permanent-Magnet Motors
  • 2024
  • Ingår i: IEEE Transactions on Transportation Electrification. - : IEEE Press. - 2332-7782. ; 10:1, s. 1388-1397
  • Tidskriftsartikel (refereegranskat)abstract
    • This article presents a comprehensive method to predict the electromagnetic losses in surface-mounted permanent-magnet (PM) motors based on a hybrid analytical model (HAM). HAM will significantly improve the calculation speed compared with finite-element method (FEM) while keeping great accuracy, making it a competitive alternative for the analysis and optimization of PM motors. As the accurate field distribution is the bias of electromagnetic losses prediction, the magnet loss, sleeve loss, and copper loss can all be accurately obtained from their vector potential distribution using HAM with small computational burden. As for iron loss, the improved Jiles–Atherton (JA) model is proposed to build the relationship between the loss and the magnetic field in the iron region from the perspective of energy conversion. The predictions of magnet loss, sleeve loss, and copper loss using HAM agree well with the FEM. The experiment on surface-mounted PM prototype demonstrates the high accuracy of iron loss calculation using the combination of the improved JA model and HAM.
  •  
31.
  • Liu, Ang, et al. (författare)
  • Nonlinear Analytical Model-Embedded Optimal Design for ER-PMSM
  • 2024
  • Ingår i: IEEE Transactions on Magnetics. - : IEEE Press. - 0018-9464 .- 1941-0069. ; 60:3, s. 1-5
  • Tidskriftsartikel (refereegranskat)abstract
    • This article proposed a nonlinear analytical model (NAM)-embedded optimal design procedure for permanent-magnet synchronous motors with an external rotor. Combined with the winding inductance calculation, a refined magnetic circuit is proposed for the analytical prediction of the electromagnetic performance. The stator nonlinearity, which is significant in torque prediction, is considered by using the conception of saturation current. Then, ant colony algorithm is employed for the multi-objective optimization for the great potential in global exploring. Finally, optimal design parameters are selected from the Pareto front. The effectiveness of the proposed optimization design method is verified by finite-element analysis (FEA) and experimental results of the manufactured prototype.
  •  
32.
  • Liu, C., et al. (författare)
  • Inhibitor of differentiation 1 is a candidate prognostic marker in multicentric Castleman's disease
  • 2014
  • Ingår i: Annals of Hematology. - : Springer Science and Business Media LLC. - 0939-5555 .- 1432-0584. ; 93:7, s. 1177-1183
  • Tidskriftsartikel (refereegranskat)abstract
    • Castleman's disease (CD) is a benign lymphoproliferative disorder characterized by dysfunctional lymphatic node hyperplasia. Lymphatic node hyperplasia is associated with elevated levels of inhibitor of differentiation 1 (ID1) in many human tumors. To assess the possible role of ID1 expression as a prognostic marker in multicentric CD (MCD), intra-lymph node ID1 expression was analyzed and related to clinical characteristics and outcomes in 48 patients. Furthermore, the correlation between ID1 and possible signaling molecules such as interleukin-6 (IL6), phosphorylated extracellular response kinase (p-ERK), and vascular endothelial growth factor C (VEGFC) was explored on six fresh MCD surgical specimens. Immunohistochemistry revealed that the patients with extensive ID1 expression had significantly poorer prognosis, compared to those with localized ID1. In addition, ID1 was positively associated with levels of IL6, p-ERK, and VEGFC. We conclude that ID1 may ultimately be a prognostic marker in MCD and that the IL6/ERK/VEGFC pathway is involved in the progress of this disease.
  •  
33.
  • Ma, Zhuo, et al. (författare)
  • Deciphering early human pancreas development at the single-cell level
  • 2023
  • Ingår i: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding pancreas development can provide clues for better treatments of pancreatic diseases. However, the molecular heterogeneity and developmental trajectory of the early human pancreas are poorly explored. Here, we performed large-scale single-cell RNA sequencing and single-cell assay for transposase accessible chromatin sequencing of human embryonic pancreas tissue obtained from first-trimester embryos. We unraveled the molecular heterogeneity, developmental trajectories and regulatory networks of the major cell types. The results reveal that dorsal pancreatic multipotent cells in humans exhibit different gene expression patterns than ventral multipotent cells. Pancreato-biliary progenitors that generate ventral multipotent cells in humans were identified. Notch and MAPK signals from mesenchymal cells regulate the differentiation of multipotent cells into trunk and duct cells. Notably, we identified endocrine progenitor subclusters with different differentiation potentials. Although the developmental trajectories are largely conserved between humans and mice, some distinct gene expression patterns have also been identified. Overall, we provide a comprehensive landscape of early human pancreas development to understand its lineage transitions and molecular complexity. Here, the authors revealed molecular heterogeneity, developmental trajectory and regulatory network of early human pancreas development, and depict the whole progression of pancreatic organogenesis during the first trimester at the single-cell level.
  •  
34.
  • Mao, Jia, et al. (författare)
  • A 90nm CMOS UHF/UWB asymmetric transceiver for RFID readers
  • 2011
  • Ingår i: European Solid-State Circuits Conference. ; , s. 179-182
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This paper presents an integrated asymmetric transceiver in 90nm CMOS technology for RFID reader. The proposed reader uses UHF transmitter to power up and inventory the tags. In the reverse link, a non-coherent Ultra-wide Band (UWB) receiver is deployed for data reception with high throughput and ranging capability. The transmitter delivers 160 kb/s ASK modulated data by an integrated modulator and a Digital Controlled Oscillator (DCO) in UHF band with 11% tuning range. The DCO consume 6 mW with 0.12 mm2 area. On the other side, adopting two integration channels, the 3-5 GHz energy detection receiver supports maximum 33 Mb/s data rate both in OOK and PPM modulations. The receiver front-end provides 59 dB voltage gain and 8.5 dB noise figure (NF). Measurement results shows that the receiver achieves an input sensitivity of -79 dBm at 10 Mb/s, with power consumption of 15.5 mW.
  •  
35.
  • Mao, Jia, et al. (författare)
  • A hybrid reader tranceiver design for industrial internet of things
  • 2016
  • Ingår i: Journal of Industrial Information Integration. - : Elsevier. - 2467-964X .- 2452-414X. ; 2, s. 19-29
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents an integrated asymmetric UHF/UWB reader transceiver in 90 nm CMOS technology for industrial enterprise IoT applications. The reader uses UHF transmitter to power up and inventory the tags. Instead of backscattering, tag replies the reader using Ultra-wideband (UWB) pulses, allowing high throughput transmission and precise positioning. Therefore, a UWB receiver is deployed in the proposed reader for data reception and Time-of-Arrival (ToA) estimation using energy detection schemes. The transmitter delivers 160 kb/s ASK modulated data by an integrated modulator and a Digital Controlled Oscillator (DCO). The DCO has 11% tuning range ability to cover different UHF signal channels. On the UWB receiver side, the 3–5 GHz energy detection receiver supports maximum 33 Mb/s data rate in both OOK and PPM modulations. The receiver front-end provides 59 dB voltage gain and 8.5 dB noise figure (NF). Measurement results shows that the receiver achieves an input sensitivity of -79 dBm at 10 Mb/s, and the power consumption of transceiver is 21.5 mW.
  •  
36.
  • Qian, Zhen, et al. (författare)
  • Vectorized dataset of roadside noise barriers in China using street view imagery
  • 2022
  • Ingår i: Earth System Science Data. - : Copernicus GmbH. - 1866-3508 .- 1866-3516. ; 14:9, s. 4057-4076
  • Tidskriftsartikel (refereegranskat)abstract
    • Roadside noise barriers (RNBs) are important urban infrastructures to ensure that cities remain liveable. However, the absence of accurate and large-scale geospatial data on RNBs has impeded the increasing progress of rational urban planning, sustainable cities, and healthy environments. To address this problem, this study creates a vectorized RNB dataset in China using street view imagery and a geospatial artificial intelligence framework. First, intensive sampling is performed on the road network of each city based on OpenStreetMap, which is used as the georeference for downloading 6 x 10(6) Baidu Street View (BSV) images. Furthermore, considering the prior geographic knowledge contained in street view images, convolutional neural networks incorporating image context information (IC-CNNs) based on an ensemble learning strategy are developed to detect RNBs from the BSV images. The RNB dataset presented by polylines is generated based on the identified RNB locations, with a total length of 2667.02 km in 222 cities. Last, the quality of the RNB dataset is evaluated from two perspectives, i.e., the detection accuracy and the completeness and positional accuracy. Specifically, based on a set of randomly selected samples containing 10 000 BSV images, four quantitative metrics are calculated, with an overall accuracy of 98.61 %, recall of 87.14 %, precision of 76.44 %, and F-1 score of 81.44 %. A total length of 254.45 km of roads in different cities are manually surveyed using BSV images to evaluate the mileage deviation and overlap level between the generated and surveyed RNBs. The root mean squared error for the mileage deviation is 0.08 km, and the intersection over union for overlay level is 88.08% +/- 2.95 %. The evaluation results suggest that the generated RNB dataset is of high quality and can be applied as an accurate and reliable dataset for a variety of large-scale urban studies, such as estimating the regional solar photovoltaic potential, developing 3D urban models, and designing rational urban layouts. Besides that, the benchmark dataset of the labeled BSV images can also support more work on RNB detection, such as developing more advanced deep learning algorithms, fine-tuning the existing computer vision models, and analyzing geospatial scenes in BSV. The generated vectorized RNB dataset and the benchmark dataset of labeled BSV imagery are publicly available at https://doi.org/10.11888/Others.tpdc.271914 (Chen, 2021).
  •  
37.
  • Qiu, WB, et al. (författare)
  • Resistin increases platelet P-selectin levels via p38 MAPK signal pathway
  • 2014
  • Ingår i: Diabetes & vascular disease research. - : SAGE Publications. - 1752-8984 .- 1479-1641. ; 11:2, s. 121-124
  • Tidskriftsartikel (refereegranskat)abstract
    • Resistin, an adipokine associated with the metabolic syndrome, is believed to have a role in thrombotic conditions. This work analyses the effects of resistin on P-selectin expression using a combination of ex vivo human studies, in vivo animal models and in vitro cell cultures. Human platelets and vascular endothelial cells were incubated with resistin, with or without anti-Toll-like receptor 4 (TLR-4) or mitogen-activated protein kinases (MAPK) pathway inhibitors, whereas mice were treated with resistin infusion followed by analysis of P-selectin expression. Resistin increased both human and murine platelet P-selectin expression compared with controls (human: 48.02% ± 7.6% vs 35.12% ± 2.62%, p < 0.05; mouse: 8.17% ± 0.37% vs 4.44% ± 0.37%, p < 0.05), through the p38 MAPK pathway. In contrast, resistin had no effect on endothelial P-selectin production. We conclude that resistin induces platelet activation by increasing P-selectin expression through the p38 MAPK-dependent pathway. These data provide one mechanism for the prothrombotic state in individuals with the metabolic syndrome.
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38.
  • Rasmussen, Morten, et al. (författare)
  • Ancient human genome sequence of an extinct Palaeo-Eskimo
  • 2010
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 463:7282, s. 757-762
  • Tidskriftsartikel (refereegranskat)abstract
    • We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
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39.
  • Tremel, Shirley, et al. (författare)
  • Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
  • 2021
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes that both contain the lipid kinase VPS34: complex II on endosomes (VPS34/VPS15/Beclin 1/UVRAG), and complex I on autophagosomes (VPS34/VPS15/Beclin 1/ATG14L). The endosomal GTPase Rab5 binds complex II, but the mechanism of VPS34 activation by Rab5 has remained elusive, and no GTPase is known to bind complex I. Here we show that Rab5a-GTP recruits endocytic complex II to membranes and activates it by binding between the VPS34 C2 and VPS15 WD40 domains. Electron cryotomography of complex II on Rab5a-decorated vesicles shows that the VPS34 kinase domain is released from inhibition by VPS15 and hovers over the lipid bilayer, poised for catalysis. We also show that the GTPase Rab1a, which is known to be involved in autophagy, recruits and activates the autophagy-specific complex I, but not complex II. Both Rabs bind to the same VPS34 interface but in a manner unique for each. These findings reveal how VPS34 complexes are activated on membranes by specific Rab GTPases and how they are recruited to unique cellular locations. The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34 complexes recruitment to and activation on membranes by specific Rab GTPases.
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40.
  • Wang, Longwei, et al. (författare)
  • A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis
  • 2023
  • Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 62:11
  • Tidskriftsartikel (refereegranskat)abstract
    • The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.
  •  
41.
  • Zhai, Chuanying, et al. (författare)
  • A 2.4-GHz ISM RF and UWB hybrid RFID real-time locating system for industrial enterprise Internet of Things
  • 2017
  • Ingår i: Enterprise Information Systems. - : Taylor & Francis. - 1751-7575 .- 1751-7583. ; 11:6, s. 909-926
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents a 2.4-GHz radio frequency (RF) and ultra-wide bandwidth (UWB) hybrid real-time locating system (RTLS) for industrial enterprise Internet of Things (IoT). It employs asymmetric wireless link, that is, UWB radio is utilised for accurate positioning up to 10 cm in critical sites, whereas 2.4-GHz RF is used for tag control and coarse positioning in non-critical sites. The specified communication protocol and the adaptive tag synchronisation rate ensure reliable and deterministic access with a scalable system capacity and avoid unpredictable latency and additional energy consumption of retransmissions due to collisions. The tag, consisting of a commercial 2.4-GHz transceiver and a customised application-specific integrated circuit (ASIC) UWB transmitter (Tx), is able to achieve up to 3 years’ battery life at 1600 tags per position update second with 1000 mAh battery in one cluster. The time difference of arrival (TDoA)–based positioning experiment at UWB radio is performed on the designed software-defined radio (SDR) platform.
  •  
42.
  • Zhai, Chuanying, et al. (författare)
  • High-Throughput and High-Efficiency Multiple Access Scheme for IEEE802.15.4 Based RFID Sensing
  • 2015
  • Ingår i: IEEE ICUWB 2015 Conference Proceedings. - : IEEE conference proceedings.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This paper presents optimizations on guard time and synchronization cycle for Time Division Multiple Access (TDMA) based deterministic Radio Frequency Identification (RFID) system. The TDMA scheme can provide guaranteed latency and high throughput for RFID system that includes fixed number of users (tags) and requests long-message transmission. However, collisions due to accumulated clock drifts of the active RFID tags equipped with independent self-clocked microcontrollers are the major challenge. In this work, we model relations between guard time and synchronization cycle used to tolerate the accumulated clock drift and reduce the probability of collisions for an extended-star RFID system. Constraints of safe guard time and synchronization cycle are proposed to consider energy efficiency and time efficiency. Moreover, optimization on guard time and synchronization cycle are explored in terms of transmission time, tag number, energy efficiency and time efficiency. The simulation results indicate that system with long transmission time (around 1 ms) enjoys higher time and energy efficiency under optimal configuration of guard time and synchronization cycle.
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43.
  • Zhao, Ying, et al. (författare)
  • Intramyocardial Dissecting Hematoma after Acute Myocardial Infarction : Echocardiographic Features and Clinical Outcome
  • 2016
  • Ingår i: Echocardiography. - : Wiley-Blackwell. - 0742-2822 .- 1540-8175. ; 33:7, s. 962-969
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: Intramyocardial dissecting hematoma (IDH) after acute myocardial infarction (MI) is a rare form of subacute cardiac rupture and hence management uncertainties. The objective of this study was to describe the clinical course of a small series of IDH patients and to review the available evidence for managing similar cases. Methods: Eight IDH patients from our center had echocardiographic, coronary angiographic and clinical outcome data reviewed. PubMed was also searched for IDH following MI. Cases were divided into three groups and compared according to the dissection location. Results: In our 8 patients, 3 had septal, 1 right ventricular (RV), and 4 left ventricular (LV) dissection. Five were medically treated and 3 surgically repaired. Reviewing the literature revealed 68 IDH patients, of mean age 66 +/- 10 years, 43 males. The percentage of IDH involving the LV free wall, septal, and RV free wall were 47%, 26.5%, and 26.5%, respectively. In the cohort as a whole, mortality was not different between surgically and medically treated patients (33.3% vs. 54.3%, P = 0.08), neither based on the IDH location (P = 0.49). While surgical and medical treatment of the LV free wall (20.0% vs. 40.9%, P = 0.25) and septal (46.2% vs. 60.0%, P = 0.60) were not different, surgical repair of RV free wall had significantly better survival (30.0% vs. 87.5%, P = 0.015). The LVEF (P = 0.82), mitral regurgitation (P = 0.49) failed to predict mortality. Conclusion: While survival following medical and surgical treatment of LV IDH is not different, patients with RV free wall dissection benefit significantly from surgical repair.
  •  
44.
  • Zhou, Bin, et al. (författare)
  • Active Fiber Gas Sensor for Methane Detecting Based on a Laser Heated Fiber Bragg Grating
  • 2014
  • Ingår i: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 26:11, s. 1069-1072
  • Tidskriftsartikel (refereegranskat)abstract
    • An active optical fiber gas sensor was developed in a cobalt-doped single mode fiber. This fiber can be heated up to a few hundred degrees Celsius by a heating laser, and a fiber Bragg grating (FBG) was fabricated inside this fiber as a thermometer. The Bragg wavelength of the FBG is sensitive to the thermal conductivity of the gas surrounding the fiber and can be used to monitor the concentration of a special gas once we know in advance the kind of gas. The proposed sensor is ideal for detecting explosive or corrosive gases in some practical application scenarios, such as gas pipeline, coal mine, flow meters, and so on. We have measured the methane concentration ranging from 0% to 4.8% (5% is its explosion limit) as a demonstration.
  •  
45.
  • Zhou, Qin, et al. (författare)
  • Low complexity burst packet detection for wireless-powered UWB RFID systems
  • 2015
  • Ingår i: 2015 IEEE International Conference on Ubiquitous Wireless Broadband (ICUWB). ; , s. 1-5
  • Konferensbidrag (refereegranskat)abstract
    • This paper addresses the issue of UWB signal acquisition in the context of wireless powered UWB RFID systems. In this scenario, the data transmission is based on short packet so as to meet the micro-power budget of autonomous power harvesting. The burst short packet transmission as well as the low duty cycling UWB pulse modulation places a stringent challenge at the UWB receiver for timing acquisition and packet detection. Besides, in a positioning enabled RFID system where variable signal-to-noise ratio (SNR) due to the variable link distance and noise background is unavoidable, conventional packet detection schemes rely on predefined threshold can hardly achieve good performance. In this study, we propose a low complexity method for burst packet detection. It is performed by sensing the preamble signal characteristic instead of the received signal strength, and thus bypassing the necessity of detection threshold. The validity of the proposed approach and its adaptivity to SNR variations is demonstrated by simulation results as well as field test with a UWB software defined radio (SDR) platform.
  •  
46.
  • Zhou, Qin, et al. (författare)
  • Noise-reducing architecture of compressed sensing receiver for IR-UWB ranging systems
  • 2016
  • Konferensbidrag (refereegranskat)abstract
    • A compressed sensing (CS) based impulse radio ultra-wideband (IR-UWB) receiver with two-path noise-reducing RF front-end architecture is proposed. By adding an identicalinput path (antenna and gain stage) together with a mixer, the noise in the received signal before feeding into the CS sampling block is alleviated comparing with the conventional CS receiver. Moreover, the mixing stage shifts the signal frequency spectrum to the lower band which eases the CS sampling hardware as well as the complexity of back-end signal reconstruction. Simulation results for a ranging system validate that the proposed CS receiver significantly outperforms the conventional one in both additive white Gaussian noise (AWGN) channel and IEEE802.15.4a multi-path channel.
  •  
47.
  • Zhu, Zikai, et al. (författare)
  • Using a VAE-SOM architecture for anomaly detection of flexible sensors in limb prosthesis
  • 2023
  • Ingår i: Journal of Industrial Information Integration. - : Elsevier BV. - 2452-414X .- 2467-964X. ; 35
  • Tidskriftsartikel (refereegranskat)abstract
    • Flexible wearable sensor electronics, combined with advanced software functions, pave the way toward increasingly intelligent healthcare devices. One important application area is limb prosthesis, where printed flexible sensor solutions enable efficient monitoring and assessing of the actual intra-socket dynamic operation conditions in clinical and other more natural environments. However, the data collected by such sensors suffer from variations and errors, leading to difficulty in perceiving the actual operational conditions. This paper proposes a novel method for detecting anomalies in the data that are collected for measuring the intra-socket dynamic operation conditions by printed flexible wearable sensors. A discrete generative model based on Variational AutoEncoder (VAE) is used first to encode the collected multi-variant time-series data in terms of latent states. After that, a clustering method based on the Self-Organizing Map (SOM) is used to acquire discrete and interpretable representations of the VAE encoded latent states. An adaptive Markov chain is utilized to detect anomalies by quantifying state transitions and revealing temporal dependencies. The contributions of the proposed architecture conclude as follows: (1) Using the VAE-SOM hybrid model to regularize the continues data as discrete states, supporting interpreting the operational data to analytic models. (2) Employing adaptive Markov chains to generalize the transitions of these states, allowing to model the complex operational conditions. Compared with benchmark methods, our architecture is validated via two public datasets and achieves the best F1 scores. Moreover, we measure the run-time performance of this lightweight architecture. The results indicate that the proposed method performs low computational complexity, facilitating the applications on real-life productions.
  •  
48.
  • Zhuo, Lang, et al. (författare)
  • Time Trade-Off Value Set for EQ-5D-3L Based on a Nationally Representative Chinese Population Survey
  • 2018
  • Ingår i: Value in Health. - : Elsevier. - 1098-3015 .- 1524-4733. ; 21:11, s. 1330-1337
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: To obtain a nationally representative Chinese three-level EuroQol five-dimensional questionnaire value set based on the time trade-off (TTO) method.Methods: A multistage, stratified, clustered random nationally representative Chinese sample was used. The study design followed an adapted UK Measurement and Valuation of Health protocol. Each respondent valued 11 random states plus state 33333 and "unconscious" using the TTO method in face-to-face interviews. Three types of models were explored: ordinary least squares, general least squares, and weighted least squares models.Results: In total, 5939 inhabitants aged 15 years and older were interviewed. Of these, 5503 satisfactorily interviewed participants were included in constructing models. An ordinary least squares model including 10 dummies without constant and N3 had a mean absolute error of 0.083 and a correlation coefficient of 0.899 between the predicted and mean values. Goodness-of-fit indices of two models based on split subsample were similar.Conclusions: TTO values were higher in our study compared with those in a study carried out in urban areas, which is mirrored by the higher values in rural areas. Several other aspects, in addition to the valuation procedure, might have influenced the results, such as factors beyond demographic factors such as view on life and death and believing in an afterlife, which need further investigation. Future studies using the three-level EuroQol five-dimensional questionnaire should consider using this value set based on a nationally representative sample of the Chinese population.
  •  
49.
  • Zou, Zhuo, et al. (författare)
  • Design and demonstration of passive UWB RFIDs : Chipless versus chip solutions
  • 2012
  • Ingår i: RFID-Technologies and Applications (RFID-TA), 2012 IEEE International Conference on. - : IEEE. - 9781467346566 ; , s. 6-11
  • Konferensbidrag (refereegranskat)abstract
    • This paper reviews recent research on Ultra-Wideband (UWB) techniques for the next generation Radio Frequency IDentification (RFID) towards the Internet-of-Things (IoT), conducted by Vinn iPack Center at KTH, Sweden. First, we introduce an inkjet printed chipless UWB RFID for ultra-low cost applications such as item-level tracking. The identification number is coded by variations of the impedance over the transmission line, resulting in the OOK modulated data by means of pulse reflections in time domain. Prototypes were fabricated and measured for 4-bit tag and 8-bit tag, respectively. Thanks to the employment of fully printing process and paper substrates, the tag is potentially ultra-low cost in volume production. Second, a wirelessly powered RFID tag with an active UWB transmitter is studied for advanced applications such as wireless positioning and sensing. The tag is powered by UHF continuous waves, whereas it uses an UWB pulse generator to transmit data to the reader. It ensures the improved coverage and accurate positioning over traditional backscattering UHF tags. UWB readers, positioning, and sensing are also discussed in a system perspective. The two solutions reveal that UWB is a viable alternative to existing passive RFIDs adapting both low-cost applications and high-performance sensing and positioning applications.
  •  
50.
  • Zou, Zhuo, et al. (författare)
  • Radio frequency identification enabled wireless sensing for intelligent food logistics
  • 2014
  • Ingår i: Philosophical Transactions. Series A. - : The Royal Society. - 1364-503X .- 1471-2962. ; 372:2017, s. 20130313-
  • Forskningsöversikt (refereegranskat)abstract
    • Future technologies and applications for the Internet of Things (IoT) will evolve the process of the food supply chain and create added value of business. Radio frequency identifications (RFIDs) and wireless sensor networks (WSNs) have been considered as the key technological enablers. Intelligent tags, powered by autonomous energy, are attached on objects, networked by short-range wireless links, allowing the physical parameters such as temperatures and humidities as well as the location information to seamlessly integrate with the enterprise information system over the Internet. In this paper, challenges, considerations and design examples are reviewed from system, implementation and application perspectives, particularly with focus on intelligent packaging and logistics for the fresh food tracking and monitoring service. An IoT platform with a two-layer network architecture is introduced consisting of an asymmetric tag-reader link (RFID layer) and an ad-hoc link between readers (WSN layer), which are further connected to the Internet via cellular or Wi-Fi. Then, we provide insights into the enabling technology of RFID with sensing capabilities. Passive, semi-passive and active RFID solutions are discussed. In particular, we describe ultra-wideband radio RFID which has been considered as one of the most promising techniques for ultra-low-power and low-cost wireless sensing. Finally, an example is provided in the form of an application in fresh food tracking services and corresponding field testing results.
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