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- Chen, J. Y., et al.
(författare)
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High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging
- 2021
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:6
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Tidskriftsartikel (refereegranskat)abstract
- Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular perturbations are sufficient to stimulate cellular changes coupled with aging. Age-associated tissue-specific molecular changes in the endothelium drive vascular loss and dictate pericyte to fibroblast differentiation. Lineage tracing of perivascular cells with inducible PDGERB and NG2 Cre mouse lines demonstrated that increased pericyte to fibroblast differentiation distinguishes injury-induced organ fibrosis and zymosan-induced arthritis. To spur further discoveries, we provide a freely available resource with 3D vascular and tissue maps.
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- Asfaw, Habtom D., et al.
(författare)
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Nanosized LiFePO4-decorated emulsion-templated carbon foam for 3D micro batteries : a study of structure and electrochemical performance
- 2014
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 6:15, s. 8804-8813
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we report a novel 3D composite cathode fabricated from LiFePO4 nanoparticles deposited conformally on emulsion-templated carbon foam by a sot-gel method. The carbon foam is synthesized via a facile and scalable method which involves the carbonization of a high internal phase emulsion (polyHIPE) polymer template. Various techniques (XRD, SEM, TEM and electrochemical methods) are used to fully characterize the porous electrode and confirm the distribution and morphology of the cathode active material. The major benefits of the carbon foam used in our work are closely connected with its high surface area and the plenty of space suitable for sequential coating with battery components. After coating with a cathode material (LiFePO4 nanoparticles), the 3D electrode presents a hierarchically structured electrode in which a porous layer of the cathode material is deposited on the rigid and bicontinuous carbon foam. The composite electrodes exhibit impressive cyclability and rate performance at different current densities affirming their importance as viable power sources in miniature devices. Footprint area capacities of 1.72 mA h cm(-2) at 0.1 mA cm(-2) (lowest rate) and 1.1 mA h cm(-2) at 6 mA cm(-2) (highest rate) are obtained when the cells are cycled in the range 2.8 to 4.0 V vs. lithium.
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| 8. |
- Asfaw, Habtom Desta, 1986-, et al.
(författare)
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Nanosized LiFePO4-decorated emulsion-templated carbon foam for 3D micro batteries : a study of structure and electrochemical performance
- 2014
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Ingår i: Nanoscale. - Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 6:15, s. 8804-8813
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we report a novel 3D composite cathode fabricated from LiFePO4 nanoparticles deposited conformally on emulsion-templated carbon foam by a sol–gel method. The carbon foam is synthesized via a facile and scalable method which involves the carbonization of a high internal phase emulsion (polyHIPE) polymer template. Various techniques (XRD, SEM, TEM and electrochemical methods) are used to fully characterize the porous electrode and confirm the distribution and morphology of the cathode active material. The major benefits of the carbon foam used in our work are closely connected with its high surface area and the plenty of space suitable for sequential coating with battery components. After coating with a cathode material (LiFePO4nanoparticles), the 3D electrode presents a hierarchically structured electrode in which a porous layer of the cathode material is deposited on the rigid and bicontinuous carbon foam. The composite electrodes exhibit impressive cyclability and rate performance at different current densities affirming their importance as viable power sources in miniature devices. Footprint area capacities of 1.72 mA h cm−2 at 0.1 mA cm−2 (lowest rate) and 1.1 mA h cm−2 at 6 mA cm−2(highest rate) are obtained when the cells are cycled in the range 2.8 to 4.0 V vs. lithium.
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- Barzegar, Hamid R., et al.
(författare)
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Simple Dip-Coating Process for the Synthesis of Small Diameter Single-Walled Carbon Nanotubes-Effect of Catalyst Composition and Catalyst Particle Size on Chirality and Diameter
- 2012
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Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 116:22, s. 12232-12239
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Tidskriftsartikel (refereegranskat)abstract
- We report on a dip-coating method to prepare catalyst particles (mixture of iron and cobalt) with a controlled diameter distribution on silicon wafer substrates by changing the solution's concentration and withdrawal velocity. The size and distribution of the prepared catalyst particles were analyzed by atomic force microscopy. Carbon nanotubes were grown by chemical vapor deposition on the substrates with the prepared catalyst particles. By decreasing the catalyst particle size to below 10 nm, the growth of carbon nanotubes can be tuned from few-walled carbon nanotubes, with homogeneous diameter, to highly pure single-walled carbon nanotubes. Analysis of the Raman radial breathing modes, using three different Raman excitation wavelengths (488, 633, and 785 nm), showed a relatively broad diameter distribution (0.8-1.4 nm) of single-walled carbon nanotubes with different chiralities. However, by changing the composition of the catalyst particles while maintaining the growth parameters, the chiralities of single-walled carbon nanotubes were reduced to mainly four different types, (12, 1), (12, 0), (8, 5), and (7, 5), accounting for about 70% of all nanotubes.
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- Fan, Lizhou, et al.
(författare)
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Promoting the Fe(VI) active species generation by structural and electronic modulation of efficient iron oxide based water oxidation catalyst without Ni or Co
- 2020
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Ingår i: Nano Energy. - : Elsevier BV. - 2211-2855 .- 2211-3282. ; 72
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Tidskriftsartikel (refereegranskat)abstract
- Fe is considered as a promising alternative for OER catalysts owing to its high natural abundance and low cost. Due to the low conductivity and sluggish catalytic kinetics, the catalytic efficiency of Fe-rich catalysts is far from less abundant Ni, Co-rich alternatives and has been hardly improved without the involvement of Ni or Co. The lower activity of Fe-rich catalysts renders the real active center of state-of-the-art NiFe, CoFe catalyst in long-term scientific debate, despite of detection of Fe-based active intermediates in these catalysts during catalytic process. In the present work, we fabricated a series of sub-5 nm Fe1-yCryOx nanocatalysts via a simple solvothermal method, achieving systematically promoted high-valent Fe(VI) species generation by structural and electronic modulation, displaying highly active OER performance without involvement of Ni or Co. Detailed investigation revealed that the high OER activity is related to the ultrasmall nanoparticle size that promotes abundant edge- and corner-site exposure at catalyst surface, which involves in OER as highly reactive site; and the incorporated Cr ions that remarkably accelerate the charge transfer kinetics, providing an effective conduit as well as suitable host for high-valent active intermediate. This work reveals the structural prerequisites for efficient Fe-rich OER catalyst fabrication, inspiring deeper understanding of the structure-activity relationship as well as OER mechanism of Fe-based catalysts.
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| 11. |
- Koguchi-Yoshioka, H, et al.
(författare)
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Skin T cells maintain their diversity and functionality in the elderly
- 2021
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 13-
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people.
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| 13. |
- Sobkowiak, Adam, et al.
(författare)
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Understanding and Controlling the Surface Chemistry of LiFeSO4F for an Enhanced Cathode Functionality
- 2013
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Ingår i: Chemistry of Materials. - : American Chemical Society (ACS). - 0897-4756 .- 1520-5002. ; 25:15, s. 3020-3029
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Tidskriftsartikel (refereegranskat)abstract
- The tavorite polymorph of LiFeSO4F has recently attracted a lot of interest as a cathode material for lithium ion batteries stimulated by its competitive specific capacity, high potential for the Fe2+/Fe3+ redox couple, and low-temperature synthesis. However, the synthesis routes explored to date have resulted in notably varied electrochemical performance. This inconsistency is difficult to understand given the excellent purity, crystallinity, and similar morphologies achieved via all known methods. In this work, we examine the role of the interfacial chemistry on the electrochemical functionality of LiFeSO4F. We demonstrate that particularly poor electrochemical performance may be obtained for pristine materials synthesized in tetraethylene glycol (TEG), which represents one of the most economically viable production methods. By careful surface characterization, we show that this restricted performance can be largely attributed to residual traces of TEG remaining on the surface of pristine materials, inhibiting the electrochemical reactions. Moreover, we show that optimized cycling performance of LiFeSO4F can be achieved by removing the unwanted residues and applying a conducting polymer coating, which increases the electronic contact area between the electrode components and creates a highly percolating network for efficient electron transport throughout the composite material. This coating is produced using a simple and scalable method designed to intrinsically favor the functionality of the final product.
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| 14. |
- Stingaciu, Marian, et al.
(författare)
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The magnetodielectric effect in BaTiO3-SrFe12O19 nanocomposites
- 2014
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Ingår i: Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. - : Royal Society of Chemistry (RSC). - 2050-7526. ; 2:2, s. 325-330
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Tidskriftsartikel (refereegranskat)abstract
- A nanoscale composite consisting of 30 vol% magnetic strontium hexaferrite SrFe12O19 embedded in a high dielectric permittivity matrix of BaTiO3 has been produced by the spark plasma sintering method. The morphology and phase composition were characterized by transmission electron microscopy (TEM) and powder X-ray diffraction (XRD) techniques. TEM micrographs indicate that no considerable grain growth occurs and different strained regions were formed by the sintering process. XRD investigations show no evidence of a chemical reaction between the constituents. The dielectric properties of such a nanocomposite were investigated versus temperature (50-300 K), frequency (100 Hz to 100 kHz) and magnetic field (0-5.6 Tesla). A magnetodielectric (MD) effect was detected in the whole studied temperature range. Above 150 K the occurrence of sharp magnetodielectric resonances around 1 kHz leads to a considerable enhancement of the effect. At temperatures below 150 K a positive MD effect was detected which is independent of the frequency.
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| 15. |
- Zetterberg, Henrik, 1973, et al.
(författare)
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Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans
- 2011
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:12, s. e28263-
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease. Animal and postmortem studies suggest that Aβ secretion can be up-regulated in response to hypoxia. We employed a new technology (Single Molecule Arrays, SiMoA) capable of ultrasensitive protein measurements and developed a novel assay to look for changes in serum Aβ42 concentration in 25 resuscitated patients with severe hypoxia due to cardiac arrest. After a lag period of 10 or more hours, very clear serum Aβ42 elevations were observed in all patients. Elevations ranged from approximately 80% to over 70-fold, with most elevations in the range of 3-10-fold (average approximately 7-fold). The magnitude of the increase correlated with clinical outcome. These data provide the first direct evidence in living humans that ischemia acutely increases Aβ levels in blood. The results point to the possibility that hypoxia may play a role in the amyloidogenic process of AD.
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