| 1. |
- Gustavsson, Ingvar, et al.
(author)
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Lab sessions in VISIR laboratories
- 2016
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In: Proceedings of 2016 13th International Conference on Remote Engineering and Virtual Instrumentation, REV 2016. - : IEEE Press. ; , s. 350-352
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Conference paper (peer-reviewed)abstract
- Experimental activities with real components are an essential part of all courses including or devoted to electrical and electronic circuits theory and practice. The knowledge triangle composed of hand-written exercises, simulations and traditional lab experiments has been enriched with the possibility for students to conduct real experiments over the Internet, using remote labs. This tutorial is devoted to one such remote lab named Virtual Instrument Systems in Reality (VISIR). The Global Online Laboratory Consortium (GOLC) elected VISIR as the best remote controlled laboratory in the world, at the first time this distinction was awarded. At the end of this tutorial, attendees are expected to know what is VISIR, what can (not) be done with it, who is currently using it, and how can one integrate it in a given course curriculum.
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| 2. |
- Hedlund, J., et al.
(author)
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Management of patients with community-acquired pneumonia treated in hospital in Sweden
- 2002
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In: Scandinavian Journal of Infectious Diseases. - 0036-5548. ; 34:12, s. 887-92
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Journal article (peer-reviewed)abstract
- To investigate the management of patients with community-acquired pneumonia (CAP) treated in hospital in Sweden, a multicentre retrospective cohort study was performed with medical record review of 982 patients (mean age 63 y) at 17 departments of infectious diseases at hospitals in Sweden. Information on antimicrobial therapy, demographic characteristics, comorbid conditions, physical examination findings, and laboratory and microbiological test results were recorded. Outcome measures were in-hospital mortality and length of hospital stay (LOS). Cultures were obtained from blood in 80% and from sputum in 22% of the patients. A microbiological aetiology was determined for 23% of the patients, with Streptococcus pneumoniae as the dominating agent (9%). The initial antibiotic treatment was mostly given intravenously (78%). Penicillin (50%) or a cephalosporin (30%) was the most common choice. Both of these drugs were usually given as a single agent. The overall mortality was 3.5% and the mean LOS was 6.4 d. Thus, the outcome was favourable despite the empirical antibiotic treatment having a narrow spectrum compared with the broader approach recommended in most recent guidelines on the management of CAP. These findings suggest that a majority of patients who are hospitalized with moderately severe pneumonia can be treated initially with penicillin alone.
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| 11. |
- Screaton, E., et al.
(author)
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Interactions between deformation and fluids in the frontal thrust region of the NanTroSEIZE transect offshore the Kii Peninsula, Japan : Results from IODP Expedition 316 Sites C0006 and C0007
- 2009
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In: Geochemistry Geophysics Geosystems. - 1525-2027. ; 10, s. Q0AD01-
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Journal article (peer-reviewed)abstract
- Integrated Ocean Drilling Program (IODP) Expedition 316 Sites C0006 and C0007 examined the deformation front of the Nankai accretionary prism offshore the Kii Peninsula, Japan. In the drilling area, the frontal thrust shows unusual behavior as compared to other regions of the Nankai Trough. Drilling results, integrated with observations from seismic reflection profiles, suggest that the frontal thrust has been active since similar to 0.78-0.436 Ma and accommodated similar to 13 to 34% of the estimated plate convergence during that time. The remainder has likely been distributed among out-of-sequence thrusts further landward and/or accommodated through diffuse shortening. Unlike results of previous drilling on the Nankai margin, porosity data provide no indication of undercompaction beneath thrust faults. Furthermore, pore water geochemistry data lack clear indicators of fluid flow from depth. These differences may be related to coarser material with higher permeability or more complex patterns of faulting that could potentially provide more avenues for fluid escape. In turn, fluid pressures may affect deformation. Well-drained, sand-rich material under the frontal thrust could have increased fault strength and helped to maintain a large taper angle near the toe. Recent resumption of normal frontal imbrication is inferred from seismic reflection data. Associated decollement propagation into weaker sediments at depth may help explain evidence for recent slope failures within the frontal thrust region. This evidence consists of seafloor bathymetry, normal faults documented in cores, and low porosities in near surface sediments that suggest removal of overlying material. Overall, results provide insight into the complex interactions between incoming materials, deformation, and fluids in the frontal thrust region.
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| 12. |
- Singh, S., et al.
(author)
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2.0 Ga Granite of the Lower Package of the Higher Himalayan Crystallines, Maglad Khad, Sutlej Valley, Himachal Pradesh
- 2006
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In: Journal of the Geological Society of India. - 0016-7622 .- 0974-6889. ; 67:3, s. 295-300
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Journal article (peer-reviewed)abstract
- Along the Sutlej valley, the lower package of the Higher Himalayan Crystallines (HHC) exposes a small concordant to discordant intrusive grey granite-The Maglad Khad Granite, within garnet mica schist/banded gneiss of the Jeori Formation. This body is fine grained and foliated along the margins, whereas the central part is relatively undeformed. This body along with aplites and pegmatites intrudes the country rock during early to syn-D-1 deformation. This is later affected by the most pervasive D-2-deformation producing gneissosity within the granite. U-Pb dating of zircons by conventional isotopic dilution technique yield an upper intercept age of 2068 +/- 5 Ma (2 sigma) from 6 zircon-fractions with MSWD=0.93, constraining the age of crystallization in the basal parts of the HHC during Early Proterozoic as well as the constraining pre-Himalayan fabric development.
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| 13. |
- Woitowich, N. C., et al.
(author)
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Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome
- 2018
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In: Iucrj. - : International Union of Crystallography (IUCr). - 2052-2525. ; 5:Part 5, s. 619-634
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Journal article (peer-reviewed)abstract
- Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states denoted Pr and Pfr with distinct absorption spectra in the red and far-red. They have recently been engineered as enzymatic photoswitches for fluorescent-marker applications in non-invasive tissue imaging of mammals. This article presents cryo- and room-temperature crystal structures of the unusual phytochrome from the non-photosynthetic myxobacterium Stigmatella aurantiaca (SaBphP1) and reveals its role in the fruitingbody formation of this photomorphogenic bacterium. SaBphP1 lacks a conserved histidine (His) in the chromophore-binding domain that stabilizes the Pr state in the classical BphPs. Instead it contains a threonine (Thr), a feature that is restricted to several myxobacterial phytochromes and is not evolutionarily understood. SaBphP1 structures of the chromophore binding domain (CBD) and the complete photosensory core module (PCM) in wild-type and Thr-to-His mutant forms reveal details of the molecular mechanism of the Pr/Pfr transition associated with the physiological response of this myxobacterium to red light. Specifically, key structural differences in the CBD and PCM between the wild-type and the Thr-to-His mutant involve essential chromophore contacts with proximal amino acids, and point to how the photosignal is transduced through the rest of the protein, impacting the essential enzymatic activity in the photomorphogenic response of this myxobacterium.
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| 14. |
- An, Junxue, et al.
(author)
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Influence of Glycosylation on Interfacial Properties of Recombinant Mucins : Adsorption, Surface Forces, and Friction
- 2017
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In: Langmuir. - : American Chemical Society. - 0743-7463 .- 1520-5827. ; 33:18, s. 4386-4395
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Journal article (peer-reviewed)abstract
- Interfacial properties of two brush-with-anchor mucins, C-P55 and C-PSLex, have been investigated at the aqueous solution/poly(methyl methacrylate) (PMMA) interface. Both are recombinant mucin-type fusion proteins, produced by fusing the glycosylated mucin part of P-selectin glycoprotein ligand-1 (PSLG-1) to the Fc part of a mouse immunoglobulin in two different cells. They are mainly expressed as dimers upon production. Analysis of the O-glycans shows that the C-PSLex mucin has the longer and more branched side chains, but C-P55 has slightly higher sialic acid content. The adsorption of the mucins to PMMA surfaces was studied by quartz crystal microbalance with dissipation. The sensed mass, including the adsorbed mucin and water trapped in the layer, was found to be similar for these two mucin layers. Atomic force microscopy with colloidal probe was employed to study surface and friction forces between mucin-coated PMMA surfaces. Purely repulsive forces of steric origin were observed between mucin layers on compression, whereas a small adhesion was detected between both mucin layers on decompression. This was attributed to chain entanglement. The friction force between C-PSLex-coated PMMA is lower than that between C-P55-coated PMMA at low loads, but vice versa at high loads. We discuss our results in terms of the differences in the glycosylation composition of these two mucins.
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| 15. |
- An, Junxue, et al.
(author)
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Influence of Glycosylation on Interfacial Properties of Recombinant Mucins: Adsorption, Surface Forces and Friction
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Other publication (other academic/artistic)abstract
- Interfacial properties of two brush-with-anchor mucins, C-P55 and C-PSLex, have been investigated at the aqueous solution/poly(methylmethacrylate) (PMMA) interface. Both are recombinant mucin-type fusion proteins, produced by fusing the glycosylated mucin part of P-selectin glycoprotein ligand-1 (PSLG-1) to the Fc part of a mouse immunoglobulin in two different cells. They are mainly expressed as dimers upon production. Analysis of the O-glycans shows that the C-PSLex mucin has the longer and more branched side chains, but C-P55 has slightly higher sialic acid content. The adsorption of the mucins to PMMA surfaces was studied by quartz crystal microbalance with dissipation. The sensed mass, including the adsorbed mucin and water trapped in the layer, was found to be similar for these two mucin layers. Atomic force microscopy with colloidal probe was employed to study surface and friction forces between mucin-coated PMMA surfaces. Purely repulsive forces of steric origin were observed between mucin layers on compression, whereas a small adhesion was detected between both mucin layers on decompression. This was attributed to chain entanglement. The friction force between C-PSLex-coated PMMA is lower than that between C-P55-coated PMMA at low loads, but vice versa at high loads. We discuss our results in terms of the differences in the glycosylation composition of these two mucins.
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| 16. |
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| 17. |
- Be'eri-Shlevin, Yaron, et al.
(author)
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Provenance of Neoproterozoic sediments in the Sarv nappes (Middle Allochthon) of the Scandinavian Caledonides : LA-ICP-MS and SIMS U-Pb dating of detrital zircons
- 2011
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In: Precambrian Research. - : Elsevier BV. - 0301-9268 .- 1872-7433. ; 187:1-2, s. 181-200
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Journal article (peer-reviewed)abstract
- We present U-Pb age data for detrital zircons from dike-intruded Neoproterozoic sedimentary rocks of the Caledonian Middle Allochthon in central Sweden and Norway. Detrital zircons from 11 samples from the Sarv, Saetra and upper Leksdal nappes (informally referred to as the Sarv nappes) are clustered within ca. 0.9-1.75 Ga, but display a bimodal distribution with major ca. 1.45-1.75 Ga and ca. 0.9-1.2 Ga components. An apparent increase of younger (0.9-1.2 Ga) components to the northwest reflects varying source terranes. Detrital zircons from an additional sample from the lower part of the Leksdal Nappe, of uncertain affiliation to the Sarv has a prominent 1.75-1.85 Ga component supporting previous suggestions that this part of the nappe belonged to a more proximal basin. Comparison of the Sarv age probability patterns with data from basement windows and basement slices within the Middle Allochthon in central Sweden and Norway supports the derivation of the sediments from the attenuated Baltican continental crust on which they were presumably deposited. Similar comparisons suggest that derivation from the southern segment of the Fennoscandian Shield or from eastern segments of Laurentia is less likely, mostly because they include also older components. We infer that the ca. 200 km wide belt of attenuated Baltican continental crust included northern extensions of Mesoproterozoic to early Neoproterozoic terranes exposed in the southern part of the Fennoscandian Shield and the easternmost part of Laurentia, which at ca. 900 Ma were still adjacent. Pre-1.75 Ga terranes of the Fennoscandian Shield were probably isolated from the Sarv distal basin(s) by intracratonic basins and uplifted margins associated with early development of this extended continental crust. The significantly older ages in the lower part of the Leksdal Nappe and its inferred more proximal position support this model. The proposed northern extension of Mesoproterozoic-early Neoproterozoic terranes can explain in a simpler way the occurrence of such detritus in many Caledonide-Appalachian allochthons exposed at the margins of the North Atlantic, with no need to infer large displacement along the axis of the Caledonide Orogen or to postulate selective transport of Grenville-age material from the south over large distances.One of our Sarv samples located at the Norwegian coast revealed Caledonian reworking at ca. 395 Ma. This age agrees with ages of late-tectonic amphibolite-facies metamorphism and pegmatite intrusion recorded in this part of the Caledonides.
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| 18. |
- Berg, S., et al.
(author)
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Serotypes of Streptococcus pneumoniae isolated from blood and cerebrospinal fluid related to vaccine serotypes and to clinical characteristics
- 2006
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In: Scand J Infect Dis. - : Informa UK Limited. - 0036-5548. ; 38:6-7, s. 427-32
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Journal article (peer-reviewed)abstract
- Pneumococci isolated from blood and cerebrospinal fluid from 1998 to 2001 in 2 counties in south-west Sweden were serotyped with the capsular reaction test. Of the 836 strains, 353 (42%), 598 (72%) and 789 (94%) belonged to serotypes included in the 7- and 11-valent pneumococcal conjugate vaccines and in the 23-valent polysaccharide vaccine, respectively. The most common serotype was type 1 (119 isolates) followed in descending frequency by serotypes 7F, 9V, 14, 4 and 12F (90-49 isolates per serotype). The coverage rates of the 7- and 11-valent conjugate vaccines among 58 strains isolated from children and adolescents 0-19 y of age were 46% and 93%, respectively. A comparison of clinical characteristics of infections caused by different serotypes showed that types 1 and 7F were less commonly associated with severe underlying diseases, that patients infected with these serotypes were younger than the average and, thus, had a lower case-fatality rate.
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| 19. |
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| 24. |
- Bäfver, Linda S, 1975, et al.
(author)
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Particle emission from combustion of oat grain and its potential reduction by addition
- 2009
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In: Fuel Processing Technology. - 0378-3820. ; 90:3, s. 353-359
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Journal article (peer-reviewed)abstract
- Second-rate cereals, unsuitable for food, can be used as fuel for small-scale production of heat and hot water.However, there are more problems related to cereals than to woody fuels. This work aims at characterisingthe particle emission from residential combustion of oat grain and its potential reduction by addition oflimestone or kaolin with the fuel. Then, to a large extent, the potassium supplied by the fuel is expected to befound in coarse particles, leaving the boiler as bottom ash, instead of being emitted to the air in the form ofsubmicron particles. Combustion experiments were performed on a residential boiler, using filter samplingand low-pressure impactors to measure the mass and number concentrations and size distributions of theemitted particles. The particles and the bottom ash were subsequently analysed for inorganic material. Tocheck the combustion conditions and basic emissions from combustion of cereals, the flue gas was analysedwith respect to gaseous O2, CO2, CO, NOx, TOC (total organic carbon), HCl and SO2. Furthermore,thermodynamic equilibrium analysis was used to support the experimental data. Finally, it is concluded thatthe particle emission can be lowered by supplying kaolin, while there was no effect of limestone.© 2008 Elsevier B.V. All rights reserved
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| 25. |
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| 26. |
- Carlsson, G, et al.
(author)
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Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia
- 2006
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In: Journal of Periodontology. - : Wiley. - 0022-3492 .- 1943-3670. ; 77:4, s. 744-751
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Journal article (peer-reviewed)abstract
- Patients with Kostmann syndrome (severe congenital neutropenia [SCN]) typically normalize their absolute neutrophil count (ANC) upon granulocyte colony-stimulating factor (G-CSF) therapy. However, although they no longer experience life-threatening bacterial infections, they frequently still have recurrent gingivitis and even severe periodontitis, often starting in early childhood. METHODS: We studied the periodontal disease in the four surviving patients belonging to the family originally described by Kostmann. Their odontological records, x-rays, color photos, bacterial cultures, serum antibodies to oral bacteria, and histopathological examinations were reviewed. The data were also correlated to previous investigations on their antibacterial peptides and molecular biology. RESULTS: Three patients had periodontal disease, despite normal ANC and professional dental care, and had neutrophils deficient in antibacterial peptides. One of these patients also had a heterozygous mutation in the neutrophil elastase gene, had severe periodontal disease and overgrowth of the periodontal pathogen Actinobacillus actinomycetemcomitans in the dental flora, and 15 permanent teeth had been extracted by the age of 27. One bone marrow-transplanted patient had no periodontal disease. CONCLUSIONS: Normalized ANC levels are not sufficient to maintain normal oral health in SCN patients, and because neutrophils are important for first-line defense and innate immunity, the deficiency of the antibacterial peptide LL-37 probably explains their chronic periodontal disease. Professional dental care is still important for SCN patients, despite treatment with G-CSF and normal ANC levels. Whether antibacterial peptides play a role in the pathogenesis of periodontitis in other patients remains to be elucidated.
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| 27. |
- Cho, DL, et al.
(author)
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Structure and surface properties of plasma polymerized acrylic acid layers
- 1990
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In: Journal of Applied Polymer Science. - 0021-8995 .- 1097-4628. ; 41, s. 1373-1390
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Journal article (peer-reviewed)abstract
- Thin plasma polymerized layers of acrylic acid (PPAA) were deposited onto polyethylene and muscovite mica surfaces. Structure and surface properties of the deposited layer depend on the polymerization conditions. The content of carboxylic groups in the layer decreases, whereas the degree of crosslinking or branching increases, with increasing discharge power. A soft, sticky layer with a low contact angle against water is obtained when a low discharge power (5 W) is used. In contrast, a hard film with a rather high water contact angle is obtained when the discharge power is high (50 W). A surface force apparatus was employed to study some film properties including adhesion force, crack formation, and capillary condensation. The adhesion force between plasma polymerized acrylic acid layers prepared at a low discharge power is high in dry air. It decreases remarkably in humid air and no adhesion is observed in water. In dry air, the adhesion force between PPAA layers decreases as the discharge power increases.
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| 28. |
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| 29. |
- Claesson, Elin, 1989, et al.
(author)
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The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
- 2020
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In: eLife. - 2050-084X. ; 9
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Journal article (peer-reviewed)abstract
- Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes. We present serial femtosecond X-ray crystallographic data of the chromophore-binding domains of a bacterial phytochrome at delay times of 1 ps and 10 ps after photoexcitation. The data reveal a twist of the D-ring, which leads to partial detachment of the chromophore from the protein. Unexpectedly, the conserved so-called pyrrole water is photodissociated from the chromophore, concomitant with movement of the A-ring and a key signaling aspartate. The changes are wired together by ultrafast backbone and water movements around the chromophore, channeling them into signal transduction towards the output domains. We suggest that the observed collective changes are important for the phytochrome photoresponse, explaining the earliest steps of how plants, fungi and bacteria sense red light.
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| 33. |
- Claesson, Hans, et al.
(author)
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Rheological behaviour during UV-curing of a star-branched polyester
- 2002
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In: Progress in organic coatings. - 0300-9440 .- 1873-331X. ; 44:1, s. 63-67
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Journal article (peer-reviewed)abstract
- Using a rheometer coupled with an UV-light generator, the viscoelastic behaviour during the fast cure of star-branched polyester is investigated. The 32 arm star polymers consist of a hyperbranched polyester core, Boltorn(TM) and linear grafts of poly(E-caprolactone) (degree of polymerisation: 20-52) with methacrylate end groups. The resins are crystalline and the melting points range from 34 to 50degreesC; films can be formed and cured below 80degreesC. The crossover of G' and G was used as the gel point. The time to reach the gel point, a few seconds, increases linearly with molecular weight.
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| 34. |
- Claesson, Hans, et al.
(author)
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Semi-crystalline thermoset resins : tailoring rheological properties in melt using comb structures with crystalline grafts
- 2004
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In: Progress in organic coatings. - : Elsevier BV. - 0300-9440 .- 1873-331X. ; 49:1, s. 13-22
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Journal article (peer-reviewed)abstract
- Thermosetting resins with semi-crystalline grafts have been synthesized. An amorphous resin with epoxide groups was first functionalized with hydroxyl groups using 2,2-bis(methylol) propionic acid, bis-MPA in bulk at 155 degreesC. Functionalization with bis-MPA was monitored using FT-IR, FT-Raman and SEC. The reaction was complete in 30 min. Grafts of poly(epsilon-caprolactone) were then grown from the hydroxyl functional resin and end capped with methacrylate groups. The polymerization Of epsilon-caprolactone, performed in bulk at 110 degreesC using Sn(Oct)(2), was characterized using H-1 NMR and SEC. The obtained molecular weights agreed well with theoretical values. The final end capping was performed using methacrylic anhydride, and monitored with SEC and H-1 NMR, which indicated full substitution. Two combs were synthesized with different arm lengths, DP 10 and 20, and the obtained M-W were close to calculated values. The complex viscosity was measured from low to high temperature for the crystalline resins, the amorphous resin and blends thereof. Rheological data show a rapid decrease in viscosity within a temperature change of 10-15 degreesC for the crystalline resins while the amorphous resin exhibited a slow softening. The blends exhibited a behavior in-between that of the crystalline and the amorphous resin. Films were prepared from the pure resins and the blends. The films were cured using UV irradiation. The comb architecture of these resins has advantages such as crystallinity, high molecular weight and low viscosity, facilitating leveling and resulting in smooth films. The final film properties varied with the ratio of crystalline to amorphous resin, where increase in the amount of crystalline resin correlated with increased the flexibility.
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| 35. |
- Claesson, Hans, et al.
(author)
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Synthesis and characterisation of star branched polyesters with dendritic cores and the effect of structural variations on zero shear rate viscosity
- 2002
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In: Polymer. - 0032-3861 .- 1873-2291. ; 43:12, s. 3511-3518
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Journal article (peer-reviewed)abstract
- A series of branched polyesters consisting of poly(epsilon-caprolactone) (PCL) (degree of polymerisation: 5-200) initiated from hydroxy-functional cores and end-capped with methylmethacrylate have been prepared. The cores were third-generation hyperbranched polyester, Boltorn, with approximately 32 hydroxyl groups, a third-generation dendrimer with 24 hydroxyl groups and a third-generation dendron with eight hydroxyl groups. Finally, a linear PCL was synthesised as a reference material. All initiators were based on 2,2-bis(methylol) propionic acid (bis-MPA). C-13 NMR spectra of the polymers showed that those with shorter arms contained unreacted hydroxyl groups on the core. Rheological measurements of zero shear rate viscosity, eta(0), showed that the branched polyesters had a considerably lower eta(0) than linear polyester with similar molecular weight. The low melt viscosity and the crystallity produced a theological behaviour suitable for the film formation process for powder coatings. Measurements of mechanical properties of cured films showed that those with low arm molecular weight, M-a, were amorphous while those of high M-a were crystalline.
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| 36. |
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| 37. |
- Claesson, Joachim, 1970-
(author)
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Thermal and hydraulic performance of compact brazed plate heat exchangers operating as evaporators in domestic heat pumps
- 2005
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Doctoral thesis (other academic/artistic)abstract
- This thesis investigates the performance of compact brazed plate heat exchangers (CBE) operating as evaporator in heat pump applications. The thesis, and the performances investigated, has been divided into three main sections; One zone evaporator performance; Two zone evaporator performance; and finally Local performance. The 'One zone evaporator performance' section considers the evaporator as one "black box". It was found that "approaching terminal temperatures" were obtained as low overall heat flux is employed. It was also found that the total area averaged film heat transfer coefficient was affected by changes of the brine mass flow rate. This indicates that the widespread Wilson plot method may not be used to determine flow boiling heat transfer coefficients. Further, it seems that co- and counter-current flow configuration performs equally well if the superheat is kept low. A numerical simulation of the above investigations indicates that a nucleate boiling model better predicts the performance compared to a convective evaporation model. Finally, the significant impact of the refrigerant inlet distributor design was illustrated using several CBEs with different inlet geometries but with identical heat transfer surfaces. The 'Two zone evaporator performance section' considers the evaporator as two "black boxes", i.e. the boiling and superheating boxes. Thermochromic liquid crystals (TLC) was used to determine the boiling heat transfer area. The resulting flow boiling heat transfer coefficient was found to correlate with heat flux. The superheated heat transfer area was then estimated using single phase correlations. It was observed that the TLC measurements and the predicted superheating area did not agree. Possible causes for this deviation were discussed. The most likely explanation found was the presence of mist flow at the higher vapor quality range in the boiling section of the evaporator. The 'Local Performance' section considers local pressure drop and flow boiling heat transfer. The Chisholm parameter was found not to be a constant and was found to correlate well with the kinetic energy per volume. The resulting predictions of the pressure drop were better than ± 10%. The resulting local flow boiling heat transfer coefficient, at different vapor quality, mass flux and heat flux, was compared to flow boiling correlations available in the literature. It was found that the saturated nucleate pool boiling correlation by Cooper (1984) and narrow channel flow boiling correlations (Tran 1999, Lazarek and Black 1982) predicted the experimental data better than several traditional flow boiling correlations, developed for larger tubes.
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| 45. |
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| 46. |
- Edlund, Petra, et al.
(author)
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The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography
- 2016
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Journal article (peer-reviewed)abstract
- Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain. Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on these conformational changes. Here we report the room temperature crystal structure of the chromophore-binding domains of the Deinococcus radiodurans phytochrome at 2.1 angstrom resolution. The structure was obtained by serial femtosecond X-ray crystallography from microcrystals at an X-ray free electron laser. We find overall good agreement compared to a crystal structure at 1.35 angstrom resolution derived from conventional crystallography at cryogenic temperatures, which we also report here. The thioether linkage between chromophore and protein is subject to positional ambiguity at the synchrotron, but is fully resolved with SFX. The study paves the way for time-resolved structural investigations of the phytochrome photocycle with time-resolved SFX.
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| 48. |
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| 49. |
- Ghaffarpour, N, et al.
(author)
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Patients with lymphatic malformations who receive the immunostimulant OK-432 experience excellent long-term outcomes
- 2015
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 104:11, s. 1169-73
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Journal article (peer-reviewed)abstract
- AIM: Sclerotherapy is the primary treatment for lymphatic malformations. The aim of this study was to evaluate the long-term outcome in patients with lymphatic malformations treated with the immunostimulant OK-432 as a sclerosant.METHODS: Between 1998 and 2013, we enrolled 131 of 138 eligible patients treated with OK-432 for lymphatic malformations in a retrospective study. The malformations were categorised according to the International Society for the Study of Vascular Anomalies. The outcome was assessed with a clinical examination and a questionnaire.RESULTS: The lymphatic malformations were localised to the head/neck (60%), the trunk (20%) and the extremities (6%) or involved with more than one region (14%). Patients with microcystic (10%), macrocystic (21%) and mixed lymphatic malformations (69%) underwent a median number of three, two and two injection treatments, respectively. The median age at the first injection was 3.4 years. Good or excellent clinical outcomes were seen in 70% of the patients. The number of injections, previous treatment and lesion localisation, but not time to follow-up and cyst size, predicted the clinical outcome.CONCLUSION: OK-432 treatment resulted in a successful outcome in 70% of patients with lymphatic malformations. The long-term outcome was comparable to the short-term outcome.
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| 50. |
- Heller, T., et al.
(author)
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Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients
- 2007
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In: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 7:7, s. 1822-1831
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Journal article (peer-reviewed)abstract
- The aim of this study was to determine whether plasma concentrations of the acyl (AcMPAG) and phenolic (MPAG) glucuronide metabolites of mycophenolic acid (MPA) were related to diarrhoea in renal transplant patients on mycophenolate mofetil (MMF) with cyclosporine (CsA) or tacrolimus (TCL). Blood samples (0, 30, 120 min) were taken at days 3, 10, week 4, months 3, 6 and 12 for determination of MPA, MPAG and AcMPAG. MPA-AUC was estimated using validated algorithms. Two hour AUCs were calculated for MPAG and AcMPAG. Immunosuppressive therapy consisted of CsA/MMF (n= 110) and of TCL/MMF (n= 180). In 70/290 (24%) patients 86 episodes of diarrhoea were recorded during 12 months. Significantly more patients on TCL (31.1%) suffered from diarrhea compared to CsA (12.7%). MMF dose, MPA-AUC and the 2 h AUCs of MPAG and AcMPAG did not differ between patients with and without diarrhoea. Plasma AcMPAG and MPAG concentrations were substantially higher in patients on CsA compared with TCL, while MPA-AUC was lower in the former group. These data support the concept that CsA inhibits the biliary excretion of MPAG and AcMPAG, thereby potentially reducing the risk of intestinal injury through enterohepatic recycling of MPA and its metabolites.
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