| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Bashkanov, M., et al.
(författare)
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Two-Pion Production in Proton-Proton Collisions
- 2003
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Ingår i: Proc. Xth Int. Conf. on Hadron Spectroscopy, HADRON’03, Aschaffenburg, Germany, 2003..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
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| 9. |
- Brodowski, W, et al.
(författare)
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Two-Pion Production in Nucleon-Nucleon Collisions
- 2002
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Ingår i: Proc. Int. Conf. on Production, Properties and Interaction of Mesons, MESON 2002, Cracow, Poland, 2002..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- Farget, F., et al.
(författare)
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Transfer-induced fission in inverse kinematics: Impact on experimental and evaluated nuclear data bases
- 2015
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 51:12, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Inverse kinematics is a new tool to study nuclear fission. Its main advantage is the possibility to measure with an unmatched resolution the atomic number of fission fragments, leading to new observables in the properties of fission-fragment distributions. In addition to the resolution improvement, the study of fission based on nuclear collisions in inverse kinematics beneficiates from a larger view with respect to the neutron-induced fission, as in a single experiment the number of fissioning systems and the excitation energy range are widden. With the use of spectrometers, mass and kinetic-energy distributions may now be investigated as a function of the proton and neutron number sharing. The production of fissioning nuclei in transfer reactions allows studying the isotopic yields of fission fragments as a function of the excitation energy. The higher excitation energy resulting in the fusion reaction leading to the compound nucleus Cf-250 at an excitation energy of 45MeV is also presented. With the use of inverse kinematics, the charge polarisation of fragments at scission is now revealed with high precision, and it is shown that it cannot be neglected, even at higher excitation energies. In addition, the kinematical properties of the fragments inform on the deformation configuration at scission.
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| 14. |
- Gaulton, Kyle J, et al.
(författare)
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
- 2015
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
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Tidskriftsartikel (refereegranskat)abstract
- We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
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| 15. |
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| 16. |
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| 17. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 18. |
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| 19. |
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| 20. |
- Kullander, Sven, et al.
(författare)
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First Results from the CELSIUS/WASA Facility
- 2003
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Ingår i: Proc. XVI Particles and Nuclei International Conference, PANIC02, Osaka, Japan, 2002, Nucl. Phys.. ; , s. 563c-
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Konferensbidrag (refereegranskat)
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| 21. |
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| 22. |
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| 23. |
- Mantovani, G., et al.
(författare)
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Study of High-Energy Fission in Inverse Kinematics
- 2019
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Ingår i: IV INTERNATIONAL CONFERENCE ON NUCLEAR STRUCTURE AND DYNAMICS (NSD2019). - : EDP Sciences. - 2100-014X. - 9782759890842 ; 223
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Konferensbidrag (refereegranskat)abstract
- Fission at low excitation energy, is a process in which both macroscopic and microscopic aspects are involved. Some features in the total kinetic energy and in the N/Z distributions of the fragments, commonly associated with shell effects, came out in a series of recent experiments with high excitation energy fusion fission reactions in inverse kinematics. In the latest experiment of this campaign, a study of high-energy fission and quasi-fission between a U-238 beam and a series of light targets was carried out by using the aforementioned technique, in order to probe the role of the shell structure in these processes.
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| 24. |
- Pätzold, Jens, et al.
(författare)
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Exclusive measurements of the pp --> pp pi+pi- reaction
- 2002
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Ingår i: Proc. 9th Int. Symp. on Meson-Nucleon Physics and the Structure of the Nucleon, MENU 2001, Washington D.C., USA, 2001., piN Newsletter. ; , s. 370-
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Konferensbidrag (refereegranskat)
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| 25. |
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| 26. |
- Ramos, D., et al.
(författare)
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Dependence of Fission-Fragment Properties On Excitation Energy For Neutron-Rich Actinides
- 2016
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. - 9782759819706 ; 111
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Konferensbidrag (refereegranskat)abstract
- Experimental access to full isotopic fragment distributions is very important to determine the features of the fission process. However, the isotopic identification of fission fragments has been, in the past, partial and scarce. A solution based on the use of inverse kinematics to study transfer-induced fission of exotic actinides was carried out at GANIL, resulting in the first experiment accessing the full identification of a collection of fissioning systems and their corresponding fission fragment distribution. In these experiments, a U-238 beam at 6.14 AMeV impinged on a carbon target to produce fissioning systems from U to Am by transfer reactions, and Cf by fusion reactions. Isotopic fission yields of Cf-250, Cm-244, Pu-240, Np-239 and U-238 are presented in this work. With this information, the average number of neutrons as a function of the atomic number of the fragments is calculated, which reflects the impact of nuclear structure around Z=50, N=80 on the production of fission fragments. The characteristics of the Super Long, Standard I, Standard II, and Standard III fission channels were extracted from fits of the fragment yields for different ranges of excitation energy. The position and contribution of the fission channels as function of excitation energy are presented.
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| 27. |
- Ramos, D., et al.
(författare)
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Experimental evidence of the effect of nuclear shells on fission dissipation and time
- 2023
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 107:2
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Tidskriftsartikel (refereegranskat)abstract
- Nuclear fission is still one of the most complex physical processes we can observe in nature due to the interplay of macroscopic and microscopic nuclear properties that decide the result. An example of this coupling is the presence of nuclear dissipation as an important ingredient that contributes to drive the dynamics and has a clear impact on the time of the process. However, different theoretical interpretations, and scarce experimental data make it poorly understood. In this Letter, we present the first experimental determination of the dissipation energy in fission as a function of the fragment split, for three different fissioning systems. The amount of dissipation was obtained through the measurement of the relative production of fragments with even and odd atomic numbers with respect to different initial fission energies. The results reveal a clear effect of particular nuclear shells on the dissipation and fission dynamics. In addition, the relative production of fragments with even and odd atomic numbers appears as a potential contributor to the long-standing problem of the time scale in fission.
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| 28. |
- Ramos, D., et al.
(författare)
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First Direct Measurement of Isotopic Fission-Fragment Yields of 239U
- 2019
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 123:9
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Tidskriftsartikel (refereegranskat)abstract
- A direct and complete measurement of isotopic fission-fragment yields of U-239 has been performed for the first time. The U-239 fissioning system was produced with an average excitation energy of 8.3 MeV in one-neutron transfer reactions between a U-239 beam and a Be-9 target at Coulomb barrier energies. The fission fragments were detected and isotopically identified using the VAMOS++ spectrometer at the GANIL facility. The measurement allows us to directly evaluate the fission models at excitation energies of fast neutrons, which are relevant for next-generation nuclear reactors. The present data, in agreement with model calculations, do not support the recently reported anomaly in the fission-fragment yields of U-239, and they confirm the persistence of spherical shell effects in the Sn region at excitation energies exceeding the fission barrier by a few mega-electron volts.
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| 29. |
- Ramos, D., et al.
(författare)
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Fission Yields of Minor Actinides at Low Energy Through Multi-nucleon Transfer Reactions of 238U on 12C
- 2015
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Ingår i: Acta Physica Polonica, Series B.. - 1509-5770 .- 0587-4254. ; 46:3, s. 443-446
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Tidskriftsartikel (refereegranskat)abstract
- First preliminary results of fragments distribution as a function of the excitation energy for different fissioning systems from U to Cm and Cf-250 are presented. A new method based on inverse kinematics to study transfer-induced fission of minor actinides was carried out in GANIL in 2008, and again in 2011. In these experiments, a U-238 beam at 6.1 A MeV impinged on a carbon target to produce fissioning systems by multi-nucleon transfer reactions, resulting in the first experiments accessing the full identification of a collection of fissioning systems and their corresponding fission fragments distribution. The excitation energy is deduced from the detection of the recoil nucleus in an angular DE-E stripped silicon telescope, and the identification of the fragments is made possible by the VAMOS spectrometer.
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| 30. |
- Ramos, D., et al.
(författare)
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Insight into excitation energy and structure effects in fission from isotopic information in fission yields
- 2019
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 99:2
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Tidskriftsartikel (refereegranskat)abstract
- The use of the inverse kinematics technique and a magnetic spectrometer permits the simultaneous measurement of proton and neutron content of full fission fragment distributions. This paper reports new measurements of five fissioning systems - U238,Np239,Pu240,Cm244, and Cf250 - produced in inelastic scattering, transfer, and fusion reactions at different excitation energies. As a result, isotopic, elemental, and isotonic fission yields are presented. The contribution of the different fission modes and the proton even-odd effect are studied. Structure effects are investigated by means of the neutron excess and the total neutron multiplicity as a function of the fragment atomic number.
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| 31. |
- Ramos, D., et al.
(författare)
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Isotopic fission-fragment distributions of U-238, Np-239, Pu-240, Cm-244, and Cf-250 produced through inelastic scattering, transfer, and fusion reactions in inverse kinematics
- 2018
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 97:5
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Tidskriftsartikel (refereegranskat)abstract
- Transfer- and fusion-induced fission in inverse kinematics has proved to be a powerful tool to investigate nuclear fission, widening information on the fission fragments and access to unstable fissioning systems with respect to other experimental approaches. An experimental campaign is being carried out at GANIL with this technique since 2008. In these experiments, a beam of U-238, accelerated to 6.1 MeV/u, impinges on a C-12 target. Fissioning systems from U to Cf are populated through inelastic scattering, transfer, and fusion reactions, with excitation energies that range from a few MeV up to 46 MeV. The use of inverse kinematics, the SPIDER telescope, and the VAMOS spectrometer allow the characterization of the fissioning system in terms of mass, nuclear charge, and excitation energy, and the isotopic identification of the full fragment distribution. This work reports on new data from the second experiment of the campaign on fission-fragment yields of the heavy actinides U-238, Np-239, Pu-240, Cm-244, and Cf-250, which are of interest from both fundamental and application points of view.
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| 32. |
- Ramos, D., et al.
(författare)
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Scission configuration of U-239 from yields and kinetic information of fission fragments
- 2020
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 101:3
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Tidskriftsartikel (refereegranskat)abstract
- The simultaneous measurement of the isotopic fission-fragment yields and fission-fragment velocities of U-239 has been performed for the first time. The U-239 fissioning system was produced in one-neutron transfer reactions between a U-238 beam at 5.88 MeV/nucleon and a Be-9 target. The combination of inverse kinematics at low energy and the use of the VAMOS + + spectrometer at the GANIL facility allows the isotopic identification of the full fission-fragment distribution and their velocity in the reference frame of the fissioning system. The proton and neutron content of the fragments at scission, their total kinetic and total excitation energy, as well as the neutron multiplicity were determined. Information from the scission point configuration is obtained from these observables and the correlation between them. The role of the octupole-deformed proton and neutron shells in the fission-fragment production is discussed.
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| 33. |
- Rodriguez-Tajes, C., et al.
(författare)
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Isotopic distributions of fission fragments from transfer-induced fission
- 2013
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Ingår i: Physics Procedia. - : Elsevier BV. - 1875-3884 .- 1875-3892. ; 47, s. 125-130
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Konferensbidrag (refereegranskat)abstract
- Fissioning systems from U to Cm as well as 250Cf were produced by 238U+12C transfer and fusion reactions. The detection of the target-like transfer partner made the characterization of the fissioning systems in (Z, A) and excitation energy possible. The isotopic identification of the fission fragments was achieved by using the VAMOS spectrometer combined to with reactions in inverse kinematics. Results regarding the populated transfer channels and excitation of the target-like transfer partner are presented, as well as the 240Pu fission probability. Isotopic yields of the fission-fragments for 240,*241Pu and 250Cf, having excitation energies of about 10 and 45 MeV, respectively, are discussed.
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| 34. |
- Rodriguez-Tajes, C., et al.
(författare)
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Transfer reactions in inverse kinematics: An experimental approach for fission investigations
- 2014
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 89:2
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Tidskriftsartikel (refereegranskat)abstract
- Inelastic and multinucleon transfer reactions between a U-238 beam, accelerated at 6.14 MeV/u, and a C-12 target were used for the production of neutron-rich, fissioning systems from U to Cm. A Si telescope, devoted to the detection of the targetlike nuclei, provided a characterization of the fissioning systems in atomic and mass numbers, as well as in excitation energy. Cross sections and angular and excitation-energy distributions were measured for the inelastic and transfer channels. Possible excitations of the targetlike nuclei were experimentally investigated for the first time, by means of gamma-ray measurements. The decays from the first excited states of 12C, B-11, and Be-10 were observed with probabilities of 0.12-0.14, while no evidence for the population of higher-lying states was found. Moreover, the fission probabilities of U-238, Np-239 and Pu-240,Pu-241,Pu-242 and Cm-244 were determined as a function of the excitation energy.
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| 35. |
- Scott, Robert A., et al.
(författare)
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
- 2017
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 66:11, s. 2888-2902
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Tidskriftsartikel (refereegranskat)abstract
- To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 x 10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations were driven by common single nucleotide variants. Credible sets of potentially causal variants were generally larger than those based on imputation with earlier reference panels, consistent with resolution of causal signals to common risk haplotypes. Stratification of T2D-associated loci based on T2D-related quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin secretion and in adipocytes, monocytes, and hepatocytes for insulin action-associated loci. These findings highlight the predominant role played by common variants of modest effect and the diversity of biological mechanisms influencing T2D pathophysiology.
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| 36. |
- Skorodko, Tatiana, et al.
(författare)
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Measurement of the p n ---> p p pi0 pi- reaction in search of the ABC resonance
- 2012
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Ingår i: Proceedings of 12th International Workshop on Production, properties and interaction of mesons (MESON 2012). - Les Ulis Cedex, France : EDP Sciences. ; , s. 09033-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- With pd collisions at T_p = 1.2 GeV exclusive measurements of the quasi-free pn -> pppi^0pi^- reaction have been carried out. Using the WASA detector setup at COSY total and differential cross sections have been obtained for the energy region &radics = 2.35 - 2.48 GeV. Though this includes the region of the ABC effect and its associated resonance structure, no low-mass enhancement (ABC effect) is found in the pi^0pi^--invariant mass spectrum - in agreement with the constraint from Bose statistics demanding the isovector pion pair to be in relative p-wave. Conventional calculations including t-channel processes for Roper, Delta(1600) and DeltaDelta excitations and their decays, which are well-known from the study of the two-pion production in pp collisions, provide a reasonable description of the data at high energies, but fall low at low energies. From this we conclude that a large contribution from a so far unknown isoscalar low-energy process is missed in the calculations. Inclusion of the ABC resonance at m = 2.37 GeV with Gamma = 70 MeV and I(J^P) = 0(3^+), which was recently observed in the pn -> dpi^0pi^0 reaction, leads to a much improved description of the data at low energies.
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| 37. |
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| 38. |
- Thomsen, HS, et al.
(författare)
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Metformin and contrast media
- 2010
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Ingår i: Radiology. - : Radiological Society of North America (RSNA). - 1527-1315 .- 0033-8419. ; 256:2, s. 672-673
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 39. |
- Thomsen, Henrik S., et al.
(författare)
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Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines
- 2013
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 23:2, s. 307-318
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Tidskriftsartikel (refereegranskat)abstract
- To update the guidelines of the Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) on nephrogenic systemic fibrosis and gadolinium-based contrast media. Topics reviewed include the history, clinical features and prevalence of nephrogenic systemic fibrosis and the current understanding of its pathophysiology. The risk factors for NSF are discussed and prophylactic measures are recommended. The stability of the different gadolinium-based contrast media and the potential long-term effects of gadolinium in the body have also been reviewed. aEuro cent Clinical features, risk factors and prevention of nephrogenic systemic fibrosis are reviewed aEuro cent Patients with GFR below 30 ml/min/1.73 m (2) have increased risk of developing NSF aEuro cent Low stability gadolinium contrast media show the strongest association with NSF aEuro cent Following guidelines regarding gadolinium contrast agents minimises the risk of NSF aEuro cent Potential long-term harm from gadolinium accumulation in the body is discussed.
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