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1.	Wang, J., et al. (author) Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota 2016 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:11, s. 1396-1406 Journal article (peer-reviewed)abstract Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor). We observe significant shifts in the microbiota of Vdr(-/-) mice relative to control mice and correlations between the microbiota and serum measurements of selected bile and fatty acids in humans, including known ligands and downstream metabolites of VDR. Genome-wide significant (P < 5 x 10(-8)) associations at multiple additional loci identify other important points of host-microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components. Non-genetic and genetic factors each account for approximately 10% of the variation in gut microbiota, whereby individual effects are relatively small.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Wang, J. (1); Schwarz, K. (1); Rosenstiel, P (1); Marschall, Hanns-Ulr ... (1); Sun, J. (1); D'Amato, M (1); show more...; Franke, A (1); Degenhardt, F (1); Al-Dury, Samer (1); Ellinghaus, D (1); Holm, K (1); Lieb, W (1); Esko, T (1); Rimbach, G (1); Koch, M. (1); Karlsen, T. H. (1); Hov, J. R. (1); Pan, W. H. (1); Hubenthal, M. (1); Kummen, M (1); Laudes, M (1); Rausch, P (1); Szymczak, S (1); Kunzel, S (1); Thingholm, L. B. (1); Baines, J. F. (1); Skieceviciene, J (1); Hasler, R. (1); Sommer, F. (1); Nothlings, U (1); Bohov, P (1); Heinsen, F. A. (1); Ruhlemann, M. C. (1); Pricop-Jeckstadt, M. (1); Bethune, J. (1); Berge, R. K. (1); Hubbe, P. (1); Sheibani-Tezerji, R. (1); Cloppenborg-Schmidt, ... (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2016 (1)

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