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  • De Luca, Michele, et al. (författare)
  • Advances in stem cell research and therapeutic development
  • 2019
  • Ingår i: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 21:7, s. 801-811
  • Forskningsöversikt (refereegranskat)abstract
    • Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental approaches, caveats and results underpinning the clinical use of such stem cells.
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  • Stacey, Glyn N, et al. (författare)
  • Stem cell culture conditions and stability : a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform
  • 2019
  • Ingår i: Regenerative Medicine. - : Future Medicine Ltd. - 1746-0751 .- 1746-076X. ; 14:3, s. 243-255
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, biomanufacturing and regulation, to discuss key issues in assuring appropriate manufacturing conditions for delivery of effective and safe products from these cell types. This report summarizes the key issues discussed and records consensus reached by delegates and emphasizes the need for accurate language and nomenclature in the scientific discourse around stem cells.
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  • Resultat 1-4 av 4

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