| 1. |
|
|
| 2. |
- Sodergren, Erica, et al.
(författare)
-
The genome of the sea urchin Strongylocentrotus purpuratus.
- 2006
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 314:5801, s. 941-52
-
Tidskriftsartikel (refereegranskat)abstract
- We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
|
|
| 3. |
- Beyler, C., et al.
(författare)
-
Oxygen consumption calorimetry, William Parker: 2016 DiNenno Prize
- 2017
-
Ingår i: Fire Science Reviews. - : Springer Science and Business Media LLC. - 2193-0414. ; 6:1
-
Tidskriftsartikel (refereegranskat)abstract
- The 2016 DiNenno Prize recognizes oxygen consumption calorimetry as a significant technical achievement that has had a major impact on public safety. Oxygen consumption calorimetry has made the measurement of heat release rate of a fire a routine part of fire testing for both research and for regulatory compliance. Heat release rate is a primary metric of fire size which is foundational in modern fire protection engineering. The 2016 Philip J. DiNenno Prize is awarded to Dr. William Parker, with ample commendation to his deceased collaborator, Dr. Clayton Huggett. Others who made contributions to the early development and application of oxygen consumption calorimetry include Peter Hinkley, William Christian, Thomas Waterman, Darryl Sensenig, Ralph Krause, Richard Gann, Vyto Babrauskas, Gunnar Heskestad, Norm Alvares, Donald Beason, and Brady Williamson. This review presents an overview of the background to the technological development and its impact on public safety
|
|
| 4. |
- Croce, P., et al.
(författare)
-
Fast-Response Sprinkler Technology : Hsiang-Cheng Kung, Gunnar Heskestad, Robert Bill, Roger Allard: The 2019 Phillip J. DiNenno Prize
- 2020
-
Ingår i: Fire Technology. - : Springer Science and Business Media LLC. - 0015-2684 .- 1572-8099. ; 56:5, s. 1981-2001
-
Tidskriftsartikel (refereegranskat)abstract
- The National Fire Protection Association has recognized fast-response sprinkler technology, developed and promulgated by Factory Mutual Research Corporation (FMRC, now FM Global), with its 2019 Phillip J. DiNenno Prize. This technology was the result of three innovative efforts that produced Response-Time Index (RTI), quick-response (QR) residential sprinklers, and the Early Suppression, Fast Response (ESFR) sprinkler. Cheng Yao (deceased), who led sprinkler research at FMRC (now FM Global), was the prime mover for this work. Dr. Gunnar Heskestad was responsible for conceptual work and much of the research and development work for RTI, as well as a good deal of the underlying research for ESFR. Dr. Hsiang-Cheng Kung did the conceptual and R&D work for QR residential sprinklers and along with Harry Shaw (deceased) supported and advocated for their acceptance into codes; he also conducted a significant amount of research work for ESFR development. Dr. Robert G. Bill provided additional experimental research work for RTI, including the adaptation of the RTI wind tunnel for testing recessed, flush and concealed sprinklers, as well as support work for Heskestad’s proposed resolution to the conduction complication identified by Jerome Pepi (deceased). He also worked extensively and closely with Roger L. Allard who was instrumental in gaining global acceptance and promulgation of these technologies worldwide. As the DiNenno Prize is not awarded posthumously, only those individuals identified in bold text were awarded the prize.
|
|
| 5. |
|
|
| 6. |
- Solmi, M, et al.
(författare)
-
Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies
- 2022
-
Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 27:1, s. 281-295
-
Tidskriftsartikel (refereegranskat)abstract
- Promotion of good mental health, prevention, and early intervention before/at the onset of mental disorders improve outcomes. However, the range and peak ages at onset for mental disorders are not fully established. To provide robust, global epidemiological estimates of age at onset for mental disorders, we conducted a PRISMA/MOOSE-compliant systematic review with meta-analysis of birth cohort/cross-sectional/cohort studies, representative of the general population, reporting age at onset for any ICD/DSM-mental disorders, identified in PubMed/Web of Science (up to 16/05/2020) (PROSPERO:CRD42019143015). Co-primary outcomes were the proportion of individuals with onset of mental disorders before age 14, 18, 25, and peak age at onset, for any mental disorder and across International Classification of Diseases 11 diagnostic blocks. Median age at onset of specific disorders was additionally investigated. Across 192 studies (n = 708,561) included, the proportion of individuals with onset of any mental disorders before the ages of 14, 18, 25 were 34.6%, 48.4%, 62.5%, and peak age was 14.5 years (k = 14, median = 18, interquartile range (IQR) = 11–34). For diagnostic blocks, the proportion of individuals with onset of disorder before the age of 14, 18, 25 and peak age were as follows: neurodevelopmental disorders: 61.5%, 83.2%, 95.8%, 5.5 years (k = 21, median=12, IQR = 7–16), anxiety/fear-related disorders: 38.1%, 51.8%, 73.3%, 5.5 years (k = 73, median = 17, IQR = 9–25), obsessive-compulsive/related disorders: 24.6%, 45.1%, 64.0%, 14.5 years (k = 20, median = 19, IQR = 14–29), feeding/eating disorders/problems: 15.8%, 48.1%, 82.4%, 15.5 years (k = 11, median = 18, IQR = 15–23), conditions specifically associated with stress disorders: 16.9%, 27.6%, 43.1%, 15.5 years (k = 16, median = 30, IQR = 17–48), substance use disorders/addictive behaviours: 2.9%, 15.2%, 48.8%, 19.5 years (k = 58, median = 25, IQR = 20–41), schizophrenia-spectrum disorders/primary psychotic states: 3%, 12.3%, 47.8%, 20.5 years (k = 36, median = 25, IQR = 20–34), personality disorders/related traits: 1.9%, 9.6%, 47.7%, 20.5 years (k = 6, median = 25, IQR = 20–33), and mood disorders: 2.5%, 11.5%, 34.5%, 20.5 years (k = 79, median = 31, IQR = 21–46). No significant difference emerged by sex, or definition of age of onset. Median age at onset for specific mental disorders mapped on a time continuum, from phobias/separation anxiety/autism spectrum disorder/attention deficit hyperactivity disorder/social anxiety (8-13 years) to anorexia nervosa/bulimia nervosa/obsessive-compulsive/binge eating/cannabis use disorders (17-22 years), followed by schizophrenia, personality, panic and alcohol use disorders (25-27 years), and finally post-traumatic/depressive/generalized anxiety/bipolar/acute and transient psychotic disorders (30-35 years), with overlap among groups and no significant clustering. These results inform the timing of good mental health promotion/preventive/early intervention, updating the current mental health system structured around a child/adult service schism at age 18.
|
|
| 7. |
- Agostini, Marco, 1987, et al.
(författare)
-
A mixed mechanochemical-ceramic solid-state synthesis as simple and cost effective route to high-performance LiNi0.5Mn1.5O4 spinels
- 2017
-
Ingår i: Electrochimica Acta. - : Elsevier BV. - 0013-4686. ; 235, s. 262-269
-
Tidskriftsartikel (refereegranskat)abstract
- The implementation of high potential materials as positive electrodes in high energy Li-ion batteries requires to develop scalable and smart synthetic routes. In the case of the LiNi0.5Mn1.5O4 (LNMO) spinel material, a successful preparation strategy must drive the phase formation in order to obtain structural, morphological and surface properties capable to boost performances in lithium cells and minimize the electrolyte degradation. Here we discuss a novel simple and easily scalable mechanochemical synthetic route, followed by a high temperature annealing in air, to prepare LMNO materials starting from oxides. A synergic doping with chromium and iron has been incorporated, resulting in the spontaneous segregation of a CrOx-rich surface layer. The effect of the annealing temperature on the physico-chemical properties of the LMNO material has been investigated as well as the effect on the performances in Licells.
|
|
| 8. |
|
|
| 9. |
- Maroni, F., et al.
(författare)
-
Highly Stable Fe3O4/C Composite: A Candidate Material for All Solid-State Lithium-Ion Batteries
- 2020
-
Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 1945-7111 .- 0013-4651. ; 167:7
-
Tidskriftsartikel (refereegranskat)abstract
- Fe3O4 nanoparticles synthesized by a base catalyzed method are tested in an All-Solid-State (ASLB) battery using a sulfide electrolyte. The pristine nanoparticles were morphologically characterized showing an average size of 12 nm. The evaluation of the electrochemical properties shows high specific capacity values of 506 mAhg(-1) after 350 cycles at a specific current of 250 mAg(-1), with very high stability and coulombic efficiency. (C) 2020 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited.
|
|
| 10. |
- Maroni, Fabio, et al.
(författare)
-
V2O5 Cryogel: A Versatile Electrode for All Solid State Lithium Batteries
- 2019
-
Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 1945-7111 .- 0013-4651. ; 166:16, s. A3927-A3931
-
Tidskriftsartikel (refereegranskat)abstract
- All solid-state lithium batteries (ASLB) are paving the attention of the battery community due to the possibility of improving safety at good energy level. Their future development requires the investigation of new electrodes chemistries both based on intercalation or conversion mechanism. In this work we report on the synthesis and characterization of a V2O5 cryogel electrode and its application in ASLB. The combination of V2O5 cryogel and a solid-state electrolyte shows appealing properties of high capacity and enhanced safety.
|
|
| 11. |
- Pigliautile, M, et al.
(författare)
-
Validation study of the Italian Addenbrooke's Cognitive Examination Revised in a young-old and old-old population
- 2011
-
Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 32:5, s. 301-307
-
Tidskriftsartikel (refereegranskat)abstract
- <i>Aims:</i> The main aims of the study were the translation and the subsequent validation in Italian of the Addenbrooke’s Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia in an elderly population. <i>Methods:</i> The ACE-R was translated and adapted into Italian. The Italian ACE-R was administered to a group of 179 elderly subjects (72 cognitively healthy and 107 subjects with mild dementia, mean age 75.4 ± 6.4 years). The group was stratified into two subsamples according to age, i.e. a young-old (<75 years) and an old-old (≧75 years) group, in order to evaluate the sensitivity and specificity of the test in detecting dementia in different age strata of elderly subjects. <i>Results:</i> The reliability of the Italian ACE-R was extremely good (α-coefficient = 0.85). Two different cutoffs were identified for young-old (cutoff 79; sensitivity 90% and specificity 80%) and old-old subjects (cutoff 60; sensitivity 82% and specificity 100%). <i>Conclusions:</i> The Italian ACE-R is a valid screening tool to detect dementia, especially in the old-old population, which represents not only the fastest growing age group but also the group at the highest risk of dementia in Western countries.
|
|
| 12. |
- Polidori, M. C., et al.
(författare)
-
Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects : implications for Alzheimer's disease
- 2015
-
Ingår i: Journal of neural transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 122:4, s. 523-530
-
Tidskriftsartikel (refereegranskat)abstract
- In light of the recent advances regarding the role of vascularity in Alzheimer's disease (AD) pathophysiology, the relationship between plasma levels and activities of the major antioxidant molecules and the carotid intima-media thickness (C-IMT) of older persons with no or very mild cognitive impairment was evaluated. The underlying hypothesis is that the IMT may be an indirect index of vascular damage in persons with low levels of plasma antioxidants. Plasma levels of vitamins A, C, E, of uric acid as well as activities of the plasma antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured. Plasma levels of vitamins C and E significantly decreased among participants from the first to the fourth IMT quartile, with a linear slope only for vitamin C. Compared to participants in the lowest vitamin C quartile, the probability to have IMT > 1.2 mm significantly decreased among persons from the second to the fourth quartile independent of confounders. In conclusion, only vitamin C plasma levels appear to be selectively associated with the risk of increasing C-IMT. An adequate vitamin C status might be particularly important for protection against AD and other clinical manifestations of vascular and cognitive ageing.
|
|
| 13. |
- Tripputi, P, et al.
(författare)
-
Tissue-type plasminogen activator gene is on chromosome 8.
- 1986
-
Ingår i: Cytogenetics and Cell Genetics. - 0301-0171 .- 1421-9816. ; 42:1-2, s. 24-8
-
Tidskriftsartikel (refereegranskat)abstract
- Tissue plasminogen activator is one of the two plasminogen activators, both serine proteases, that catalyze the conversion of inactive plasminogen to plasmin, which then degrades the fibrin network of blood clots. By combining somatic cell genetics, in situ hybridization, and Southern blot hybridization, we localized the human tissue plasminogen activator gene to the pericentromeric region of chromosome 8.
|
|
| 14. |
- Ückert, S., et al.
(författare)
-
Expression and distribution of key proteins of the endocannabinoid system in the human seminal vesicles
- 2018
-
Ingår i: Andrologia. - : Hindawi Limited. - 0303-4569. ; 50:2
-
Tidskriftsartikel (refereegranskat)abstract
- The endocannabinoid system (ECS), comprising the cannabinoid receptors (CBR), their ligands, and enzymes controlling the turnover of endocannabinoids, has been suggested to be involved in male reproductive function. As information is scarce on the expression of the ECS in human male reproductive tissues, this study aimed to investigate by means of molecular biology (RT-PCR) and immunohistochemistry/immunofluorescence the expression and distribution of CB1 and CB2, GPR55 (an orphan G protein-coupled receptor that recognises cannabinoid ligands) and FAAH (isoforms 1 and 2) in the human seminal vesicles (SV). The specimens expressed PCR products corresponding to CB1 (66 bp), CB2 (141 bp), GPR55 (112 bp), FAAH1 (260 bp) and FAAH2 (387 bp). Immumohistochemistry revealed dense expression of CB1, CB2 and GPR55 located to the pseudo-stratified columnar epithelium and varicose nerves (also characterised by the expression of vasoactive intestinal polypeptide and calcitonin gene-related peptide). Cytosolic staining for FAAH1 and FAAH2 was seen in cuboidal cells of all layers of the epithelium. No immunoreactivity was detected in the smooth musculature or nerve fibres. CB1, CB2, GPR55, FAAH1 and FAAH2 are highly expressed in the human SV. Considering their localisation, the ECS may be involved in epithelial homeostasis, secretory function or autonomic mechano-afferent signalling.
|
|
