| 1. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
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| 5. |
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| 6. |
- de Val-Borro, M., et al.
(författare)
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A comparative study of disc-planet interaction
- 2006
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 370:529, s. 29-
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Tidskriftsartikel (refereegranskat)abstract
- We perform numerical simulations of a disc-planet system using various grid-based and smoothed particle hydrodynamics (SPH) codes. The tests are run for a simple setup where Jupiter and Neptune mass planets on a circular orbit open a gap in a protoplanetary disc during a few hundred orbital periods. We compare the surface density contours, potential vorticity and smoothed radial profiles at several times. The disc mass and gravitational torque time evolution are analysed with high temporal resolution. There is overall consistency between the codes. The density profiles agree within about 5 per cent for the Eulerian simulations. The SPH results predict the correct shape of the gap although have less resolution in the low-density regions and weaker planetary wakes. The disc masses after 200 orbital periods agree within 10 per cent. The spread is larger in the tidal torques acting on the planet which agree within a factor of 2 at the end of the simulation. In the Neptune case, the dispersion in the torques is greater than for Jupiter, possibly owing to the contribution from the not completely cleared region close to the planet.
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| 7. |
- Barragan, O., et al.
(författare)
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The young HD 73583 (TOI-560) planetary system: two 10-M-circle plus mini-Neptunes transiting a 500-Myr-old, bright, and active K dwarf
- 2022
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 514:2, s. 1606-1627
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Tidskriftsartikel (refereegranskat)abstract
- We present the discovery and characterization of two transiting planets observed by TESS in the light curves of the young and bright (V = 9.67) star HD73583 (TOI-560). We perform an intensive spectroscopic and photometric space- and ground-based follow-up in order to confirm and characterize the system. We found that HD73583 is a young (similar to 500 Myr) active star with a rotational period of 12.08 +/- 0.11 d, and a mass and radius of 0.73 +/- 0.02 M-circle dot and 0.65 +/- 0.02 R-circle dot, respectively. HD 73583 b (P-b = 6.3980420(-0.0000062)(+0.0000067 )d) has a mass and radius of 10.2(-3.1)(+3.4) M-circle plus and 2.79 +/- 0.10 R-circle plus, respectively, which gives a density of 2.58(-0.81)(+0.95) g cm(-3). HD 73583 c (P-c = 18.87974(-0.00074)(+0.00086) d) has a mass and radius of 9.7(-1.7)(+1.8) M-circle plus and 2.39(-0.09)(+0.10) R-circle plus, respectively, which translates to a density of 3.88(-0.80)(+0.91) g cm(-3). Both planets are consistent with worlds made of a solid core surrounded by a volatile envelope. Because of their youth and host star brightness, they both are excellent candidates to perform transmission spectroscopy studies. We expect ongoing atmospheric mass-loss for both planets caused by stellar irradiation. We estimate that the detection of evaporating signatures on H and He would be challenging, but doable with present and future instruments.
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| 8. |
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| 9. |
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| 10. |
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| 11. |
- Madonna, G, et al.
(författare)
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Clinical Categorization Algorithm (CLICAL) and Machine Learning Approach (SRF-CLICAL) to Predict Clinical Benefit to Immunotherapy in Metastatic Melanoma Patients: Real-World Evidence from the Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy
- 2021
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:16
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Tidskriftsartikel (refereegranskat)abstract
- The real-life application of immune checkpoint inhibitors (ICIs) may yield different outcomes compared to the benefit presented in clinical trials. For this reason, there is a need to define the group of patients that may benefit from treatment. We retrospectively investigated 578 metastatic melanoma patients treated with ICIs at the Istituto Nazionale Tumori IRCCS Fondazione “G. Pascale” of Napoli, Italy (INT-NA). To compare patients’ clinical variables (i.e., age, lactate dehydrogenase (LDH), neutrophil–lymphocyte ratio (NLR), eosinophil, BRAF status, previous treatment) and their predictive and prognostic power in a comprehensive, non-hierarchical manner, a clinical categorization algorithm (CLICAL) was defined and validated by the application of a machine learning algorithm—survival random forest (SRF-CLICAL). The comprehensive analysis of the clinical parameters by log risk-based algorithms resulted in predictive signatures that could identify groups of patients with great benefit or not, regardless of the ICI received. From a real-life retrospective analysis of metastatic melanoma patients, we generated and validated an algorithm based on machine learning that could assist with the clinical decision of whether or not to apply ICI therapy by defining five signatures of predictability with 95% accuracy.
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| 12. |
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| 16. |
- Carleo, Ilaria, et al.
(författare)
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The Multiplanet System TOI-421*
- 2020
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 160:3
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Tidskriftsartikel (refereegranskat)abstract
- We report the discovery of a warm Neptune and a hot sub-Neptune transiting TOI-421 (BD-14 1137, TIC 94986319), a bright (V = 9.9) G9 dwarf star in a visual binary system observed by the Transiting Exoplanet Survey Satellite (TESS) space mission in Sectors 5 and 6. We performed ground-based follow-up observations-comprised of Las Cumbres Observatory Global Telescope transit photometry, NIRC2 adaptive optics imaging, and FIbre-fed Echelle Spectrograph, CORALIE, High Accuracy Radial velocity Planet Searcher, High Resolution echelle Spectrometer, and Planet Finder Spectrograph high-precision Doppler measurements-and confirmed the planetary nature of the 16 day transiting candidate announced by the TESS team. We discovered an additional radial velocity signal with a period of five days induced by the presence of a second planet in the system, which we also found to transit its host star. We found that the inner mini-Neptune, TOI-421 b, has an orbital period of P-b = 5.19672 +/- 0.00049 days, a mass of M-b = 7.17 +/- 0.66 M-circle plus, and a radius of R-b = R-circle plus, whereas the outer warm Neptune, TOI-421 c, has a period of P-c = 16.06819 +/- 0.00035 days, a mass of M-c = 16.42(-1.04)(+1.06)M(circle plus), a radius of R-c = 5.09(-0.15)(+0.16)R(circle plus), and a density of rho(c) = 0.685(-0.072)(+0.080) cm(-3). With its characteristics, the outer planet (rho(c) = 0.685(-0.0072)(+0.080) cm(-3)) is placed in the intriguing class of the super-puffy mini-Neptunes. TOI-421 b and TOI-421 c are found to be well-suited for atmospheric characterization. Our atmospheric simulations predict significant Ly alpha transit absorption, due to strong hydrogen escape in both planets, as well as the presence of detectable CH4 in the atmosphere of TOI-421 c if equilibrium chemistry is assumed.
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| 17. |
- D'Angelo, N., et al.
(författare)
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Local Inhomogeneous Weighted Summary Statistics for Marked Point Processes
- 2023
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Ingår i: Journal of Computational and Graphical Statistics. - 1061-8600 .- 1537-2715.
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a family of local inhomogeneous mark-weighted summary statistics, of order two and higher, for general marked point processes. Depending on how the involved weight function is specified, these summary statistics capture different kinds of local dependence structures. We first derive some basic properties and show how these new statistical tools can be used to construct most existing summary statistics for (marked) point processes. We then propose a local test of random labeling. This procedure allows us to identify points, and consequently regions, where the random labeling assumption does not hold, for example, when the (functional) marks are spatially dependent. Through a simulation study we show that the test is able to detect local deviations from random labeling. We also provide an application to an earthquake point pattern with functional marks given by seismic waveforms.
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| 18. |
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| 19. |
- de Val Borro, Miguel, et al.
(författare)
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Vortex generation in protoplanetary disks with an embedded giant planet
- 2007
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 471:3, s. 1043-1055
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Tidskriftsartikel (refereegranskat)abstract
- Context: Vortices in protoplanetary disks can capture solid particles and form planetary cores within shorter timescales than those involved in the standard core-accretion model. Aims: We investigate vortex generation in thin unmagnetized protoplanetary disks with an embedded giant planet with planet to star mass ratio 10-4 and 10-3.Methods: Two-dimensional hydrodynamical simulations of a protoplanetary disk with a planet are performed using two different numerical methods. The results of the non-linear simulations are compared with a time-resolved modal analysis of the azimuthally averaged surface density profiles using linear perturbation theory.Results: Finite-difference methods implemented in polar coordinates generate vortices moving along the gap created by Neptune-mass to Jupiter-mass planets. The modal analysis shows that unstable modes are generated with growth rate of order 0.3 ΩK for azimuthal numbers m=4,5,6, where ΩK is the local Keplerian frequency. Shock-capturing Cartesian-grid codes do not generate very much vorticity around a giant planet in a standard protoplanetary disk. Modal calculations confirm that the obtained radial profiles of density are less susceptible to the growth of linear modes on timescales of several hundreds of orbital periods. Navier-Stokes viscosity of the order ν=10-5 (in units of a2 Ωp) is found to have a stabilizing effect and prevents the formation of vortices. This result holds at high resolution runs and using different types of boundary conditions.Conclusions: Giant protoplanets of Neptune-mass to Jupiter-mass can excite the Rossby wave instability and generate vortices in thin disks. The presence of vortices in protoplanetary disks has implications for planet formation, orbital migration, and angular momentum transport in disks.
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| 20. |
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| 21. |
- Messas, Y. F., et al.
(författare)
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Integrating citizen nature photography to natural history science: New record of bird-lizard predation
- 2022
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Ingår i: Austral Ecology. - : Wiley. - 1442-9985 .- 1442-9993. ; 47:2, s. 456-9
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Tidskriftsartikel (refereegranskat)abstract
- Understanding high biodiverse areas and interactions among organisms requires reciprocal action between scientists and community through citizen science. This paper results from the joint efforts of an amateur nature photographer and scientists to describe the predation behaviour of the heron Ardea cocoi upon the lizard Ameiva ameiva. We also discuss the importance of citizen science and digital photography for natural history studies.
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| 22. |
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| 23. |
- Sandberg, Mats, 1953, et al.
(författare)
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NRF2-regulation in brain health and disease: Implication of cerebral inflammation
- 2014
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Ingår i: Neuropharmacology. - : Elsevier BV. - 0028-3908. ; 79, s. 298-306
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Tidskriftsartikel (refereegranskat)abstract
- The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous inducible defense systems in the body. Under physiological conditions NRF2 is mainly located in the cytoplasm. However, in response to oxidative stress, NRF2 translocates to the nucleus and binds to specific DNA sites termed "anti-oxidant response elements"or "electrophile response elements"to initiate transcription of cytoprotective genes. Acute oxidative stress to the brain, such as stroke and traumatic brain injury is increased in animals that are deficient in NRF2. Insufficient NRF2 activation in humans has been linked to chronic diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. New findings have also linked activation of the NRF2 system to anti-inflammatory effects via interactions with NF-κB. Here we review literature on cellular mechanisms of NRF2 regulation, how to maintain and restore NRF2 function and the relationship between NRF2 regulation and brain damage. We bring forward the hypothesis that inflammation via prolonged activation of key kinases (p38 and GSK-3β) and activation of histone deacetylases gives rise to dysregulation of the NRF2 system in the brain, which contributes to oxidative stress and injury. © 2013 Elsevier B.V. All rights reserved.
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