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- Mesas-Sánchez, Laura, et al.
(author)
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Non-enzymatic kinetic resolution of 1,2-azidoalcohols using a planar-chiral DMAP derivative catalyst
- 2013
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In: Tetrahedron. - : Elsevier BV. - 0040-4020 .- 1464-5416. ; 69:2, s. 753-757
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Journal article (peer-reviewed)abstract
- Optically pure 1,2-azidoalcohols are widely used as precursors for other high value organic products. A non-enzymatic kinetic resolution procedure for the stereoselective synthesis of chiral 1,2-azidoalcohols from the readily available racemic counterparts has been developed, employing a planar-chiral DMAP derivative catalyst. Following this procedure, a range of aromatic 1,2-azidoalcohols was obtained in good selectivities (up to S=45) and high enantiomeric excess (up to 99% ee).
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