| 1. |
- Lind, Lars, et al.
(författare)
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- 2021
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Ingår i: eLife. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
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| 2. |
- Bixby, H., et al.
(författare)
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
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Tidskriftsartikel (refereegranskat)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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| 3. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Taddei, C, et al.
(författare)
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Repositioning of the global epicentre of non-optimal cholesterol
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 582:7810, s. 73-
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Tidskriftsartikel (refereegranskat)abstract
- High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
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| 8. |
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| 9. |
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| 10. |
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| 11. |
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| 12. |
- Zillikens, M. C., et al.
(författare)
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 x 10(-8)) or suggestively genome wide (p < 2.3 x 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/ near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/ near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.
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| 13. |
- Emerging Risk Factors, Collaboration, et al.
(författare)
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The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases
- 2007
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Ingår i: Eur J Epidemiol. - 0393-2990. ; 22:12, s. 839-69
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Tidskriftsartikel (refereegranskat)abstract
- Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid and inflammatory markers, other characteristics, as well as major cardiovascular morbidity and cause-specific mortality. Information on repeat measurements on relevant characteristics has been collected in approximately 340,000 participants to enable estimation of and correction for within-person variability. Re-analysis of individual data will yield up to approximately 69,000 incident fatal or nonfatal first ever major cardiovascular outcomes recorded during about 11.7 million person years at risk. The primary analyses will involve age-specific regression models in people without known baseline cardiovascular disease in relation to fatal or nonfatal first ever coronary heart disease outcomes. This initiative will characterize more precisely and in greater detail than has previously been possible the shape and strength of the age- and sex-specific associations of several lipid and inflammatory markers with incident coronary heart disease outcomes (and, secondarily, with other incident cardiovascular outcomes) under a wide range of circumstances. It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Schlegel, C, et al.
(författare)
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K-isomers in very neutron-rich nuclei around mass 180
- 2000
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Ingår i: Physica Scripta. Topical Issues. - 0281-1847. ; T88, s. 72-76
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Tidskriftsartikel (refereegranskat)abstract
- gamma-spectroscopy methods have been used to search for microsecond isomers among the fragmentation products of a 1 GeV/nucleon Pb-208 beam. In particular the population of the known K-pi = 35/2(-) isomer in W-179 has been investigated and several new isomeric decays have been found for neutron rich nuclei in the A approximate to 180-200 mass region. The ground state band of the neutron rich N = 116 system of W-190 has been identified for the first time and we discuss its structure in comparison to neighboring systems.
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| 19. |
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| 20. |
- Caamano, M, et al.
(författare)
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Isomers in neutron-rich A approximate to 190 nuclides from Pb-208 fragmentation
- 2005
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 23:2, s. 201-215
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Tidskriftsartikel (refereegranskat)abstract
- Relativistic projectile fragmentation of Pb-208 has been used to produce isomers in neutron-rich, A approximate to 190 nuclides. A forward-focusing spectrometer provided ion-by-ion mass and charge identification. The detection of gamma-rays emitted by stopped ions has led to the assignment of isomers in Ta-188, W-190, Re-192, Re-193, Os-195, Ir-197, Ir-198, Pt-200, Pt-201, Pt-202 and Au-203, with half-lives ranging from approximately 10 ns to 1 ms. Tentative isomer information has been found also for Er-174, Er-175, Hf-185, Re-191, Re-194 and Ir-199. In most cases, time-correlated, singles gamma-ray events provided the first spectroscopic data on excited states for each nuclide. In Pt-200 and Pt-201. the assignments are supported by gamma-gamma coincidences. Isomeric ratios provide additional information, such as half-life and transition energy constraints in particular cases. The level structures of the platinum isotopes are discussed, and comparisons are made with isomer systematics.
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| 21. |
- Podolyak, Z, et al.
(författare)
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Isomer spectroscopy of neutron rich W-190(116)
- 2000
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 491:3-4, s. 225-231
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Gamma-rays de-exciting a millisecond isomer in the neutron-rich nucleus W-190(74)116 have been observed following relativistic projectile fragmentation of a I GeV per nucleon Pb-208 beam. Th, isomeric decay populates the ground-state rotational band, with
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| 22. |
- Schlegel, C, et al.
(författare)
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K-isomers in very neutron-rich nuclei around mass 180
- 2000
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Ingår i: PHYSICA SCRIPTA. - : ROYAL SWEDISH ACAD SCIENCES. - 0281-1847. ; T88, s. 72-76
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- gamma-spectroscopy methods have been used to search for microsecond isomers among the fragmentation products of a 1 GeV/nucleon Pb-208 beam. In particular the population of the known K-pi = 35/2(-) isomer in W-179 has been investigated and several new iso
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| 23. |
- Sylvan, G N, et al.
(författare)
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Deformation driving intruder orbitals in Kr-77
- 1997
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 56:2, s. 772-781
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Kr-77 were identified via analysis of prompt gamma-gamma coincidences in the Ni-58(Si-29,2 alpha 2p) reaction at 128 MeV at the Gammasphere facility. Evaporation channel selection was achieved using the 95 element Microball charged-particle detector. 27 new states and 42 new transitions were found, The positive-parity bands were confirmed and the alpha=-1/2 band extended to 39/2(+). The negative-parity signature pair was extended to 31/2(-) and 37/2(-). Two new high-lying negative-parity bands were found extending from a state of spin I = 15/2 and energy 2.6 MeV to 17.4 MeV at I = (55/2). The new bands appear highly deformed and become yrast at high spin. A three-quasiparticle structure based on deformation driving, low-K unique-parity and intruder orbitals is suggested for them.
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| 24. |
- DORING, J, et al.
(författare)
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EVIDENCE FOR NEW ISOMERS AND BAND STRUCTURES IN RB-80
- 1992
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 46:6, s. R2127-R2131
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in the doubly odd nucleus Rb-80 have mainly been studied via the Zn-68(F-19,alpha3n) reaction at 72 MeV beam energy utilizing the NORDBALL detector system. The level scheme has been extended up to a (15+) state at 4446 keV excitation energy. In the low-spin region seven new isomers with lifetimes in the nanosecond region have been found. In addition, a 6+ isomer with a half-life of the order of mus has been identified at an excitation energy of 494.4 keV. For the level sequence built on this isomer positive parity is suggested and the states are ascribed to the intruder two-quasiparticle configuration (pig9/2 x nug9/2) and collective excitations.
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| 25. |
- DORING, J, et al.
(författare)
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HIGH-LYING 3-QUASI-PARTICLE BANDS AND SIGNATURE SPLITTING IN RB-81
- 1994
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 50:4, s. 1845-1850
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Tidskriftsartikel (refereegranskat)abstract
- Two new high-lying level sequences of negative parity have been identified in the odd-proton nucleus Rb-81 by in-beam gamma-ray spectroscopy using the reactions Br-79(alpha, 2n) at 27 MeV and Zn-68(F-19, alpha2n) at 72 MeV. One sequence, dominated by M1 transitions, is interpreted as a three-quasiparticle band predominantly containing a neutron in the p1/2, p3/2, or f5/2 subshell coupled to g9/2 proton and g9/2 neutron excitations. The other new level sequence forms the three-quasiparticle extension of the unfavored negative-parity band, but the states decay also by E1 transitions. The signature splitting points to a configuration where an aligned g9/2 proton pair is involved.
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| 26. |
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| 27. |
- Gadea, A, et al.
(författare)
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Hindered E4 decay of the 12(+) yrast trap in Fe-52
- 2005
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 619:1-2, s. 88-94
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Tidskriftsartikel (refereegranskat)abstract
- The gamma decay of the 12(+) yrast trap in Fe-52 has been measured for the first time. The two E4 gamma-branches to the 8(+) states are hindered with respect to other B(E4) reduced transition probabilities measured in the f(7/2) shell. The interpretation of the data is given in the full pf shell model framework, comparing the results obtained with different residual interactions. It is shown that measurements of hexadecapole transition probabilities constitute a powerful tool in discriminating the correct configuration of the involved wavefunctions.
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| 28. |
- Haghikia, A., et al.
(författare)
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Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism
- 2022
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 43:6, s. 518-533
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Tidskriftsartikel (refereegranskat)abstract
- Aims Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and morbidity worldwide, and increased low-density lipoproteins (LDLs) play a critical role in development and progression of atherosclerosis. Here, we examined for the first time gut immunomodulatory effects of the microbiota-derived metabolite propionic acid (PA) on intestinal cholesterol metabolism. Methods and results Using both human and animal model studies, we demonstrate that treatment with PA reduces blood total and LDL cholesterol levels. In apolipoprotein E-/- (Apoe(-/-)) mice fed a high-fat diet (HFD), PA reduced intestinal cholesterol absorption and aortic atherosclerotic lesion area. Further, PA increased regulatory T-cell numbers and interleukin (IL)-10 levels in the intestinal microenvironment, which in turn suppressed the expression of Niemann-Pick C1-like 1 (Npc1l1), a major intestinal cholesterol transporter. Blockade of IL-10 receptor signalling attenuated the PA-related reduction in total and LDL cholesterol and augmented atherosclerotic lesion severity in the HFD-fed Apoe(-/-) mice. To translate these preclinical findings to humans, we conducted a randomized, double-blinded, placebo-controlled human study (clinical trial no. NCT03590496). Oral supplementation with 500 mg of PA twice daily over the course of 8 weeks significantly reduced LDL [-15.9 mg/dL (-8.1%) vs. -1.6 mg/dL (-0.5%), P = 0.016], total [-19.6 mg/dL (-7.3%) vs. -5.3 mg/dL (-1.7%), P = 0.014] and non-high-density lipoprotein cholesterol levels [PA vs. placebo: -18.9 mg/dL (-9.1%) vs. -0.6 mg/dL (-0.5%), P = 0.002] in subjects with elevated baseline LDL cholesterol levels. Conclusion Our findings reveal a novel immune-mediated pathway linking the gut microbiota-derived metabolite PA with intestinal Npc1l1 expression and cholesterol homeostasis. The results highlight the gut immune system as a potential therapeutic target to control dyslipidaemia that may introduce a new avenue for prevention of ACVDs.
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| 29. |
- Pavan, J, et al.
(författare)
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Lifetime measurements and terminating structures in Nb-87
- 2003
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 67:3: 034316
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Tidskriftsartikel (refereegranskat)abstract
- Two experiments have been performed using the Ni-58(S-32,3p) reaction at 135 MeV with Gammasphere and the Microball to study the high-spin structure of the transitional nucleus Nb-87. The first experiment using a thin target provided a considerable extension and refinement of the level scheme, as well as firm spin assignments from directional correlation of oriented nuclei. Sub-picosecond lifetimes were measured in the second backed-target experiment using the Doppler-shift attenuation method. The lifetimes imply a rather modest average deformation of beta(2)similar to0.1, but with considerable variation from state to state. Strong alternations were observed in the B(M1) strengths of transitions between some pairs of bands. The experimental results were compared with calculations performed within the cranked Nilsson-Strutinsky approach. The calculations generally reproduce the irregularities in the structure of the yrast lines and plunging transition quadrupole moments Q(t) within the bands explaining them as reflections of configuration changes and an approach of band termination, respectively.
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| 30. |
- Rudolph, Dirk, et al.
(författare)
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Shell-model Influence in the Rotational Nucleus 86Mo
- 1996
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 54:1, s. 117-124
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Mo-86 were studied by means of the fusion evaporation reaction Ni-58(S-32,2p2n) Mo-86 at 135 MeV beam energy. Charged-particle-gamma gamma and -gamma gamma gamma coincidences recorded with the early implementation of the GAMMASPHERE array and the MICROBALL charged-particle detection system were used to largely extend the level scheme of the T-tau=1 nucleus Mo-86 to a possible spin of I=24h at 13 MeV excitation energy. The excitation scheme is compared to neighboring nuclei. There is evidence for enhanced shell-model influence in the 4 quasiparticle region (I=12-16h). The observed (pi=+,alpha=0) sequence at spin I greater than or equal to 16 h appears to be associated with a triaxial collective rotational band. This interpretation is supported by calculations within the configuration-dependent shell-correction approach with the cranked Nilsson potential.
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| 31. |
- Sedarsky, David, 1976, et al.
(författare)
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Numerical simulation of primary atomization: Interaction with experimental analysis
- 2013
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Ingår i: Atomization and Sprays. - 1044-5110. ; 23:12, s. 1103-1138
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Tidskriftsartikel (refereegranskat)abstract
- This paper focuses on recent developments in numerical simulations and experimental techniques applied to jet atomization. Interface tracking based on coupled level-set, VOF, and ghost fluid approaches is presented, together with experimental methods including morphological analysis, multi-scale analysis, and laser correlation velocimetry. Experimental diagnostics and analysis are applied and validated against images provided by numerical simulations, allowing comparisons between experimental data, combined experimental techniques and simulated images, and pure numerical results. © 2013 by Begell House, Inc.
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| 32. |
- Sun, H., et al.
(författare)
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New Band Structures and an Unpaired Crossing in 78Kr
- 1999
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 59:2, s. 655-664
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Kr-78 were studied using the Ni-58(Na-23,3p) reaction at 70 MeV and the Ni-58(Si-23,alpha 4p) reaction at 130 MeV. Prompt gamma-gamma coincidences were measured using the Pitt-FSU detector array and the GAMMASPHERE-MICROBALL array. Results from these experiments have led to 26 new excitation levels, some of which have been grouped into 3 new bands. Spins were assigned based on directional correlations of oriented nuclei. Two of the new negative-parity bands appear to form a signature-partner pair based on a two-quasineutron structure, in contrast to the previously known two-quasiproton negative-parity bands. A forking has been observed at the 24(+) state in the yrast band, which calculations suggest may result from an unpaired crossing. The available evidence suggests oblate shapes in the yrast band coexist with prolate shapes in the negative-parity bands. [S0556-2813(99)04602-6].
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| 33. |
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| 34. |
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| 35. |
- CRISTANCHO, F, et al.
(författare)
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MULTIPLE SUPERDEFORMED BANDS IN SR-81
- 1995
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Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 357:3, s. 281-286
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Tidskriftsartikel (refereegranskat)abstract
- Four superdeformed bands extending over five to twelve transitions have been identified in Sr-81 from a study With the Gammasphere array and the Microball charged-particle array, One of the bands shows an upbend in the dynamic moment of inertia at a rotational frequency of 1.2 MeV and all bands exhibit a nearly constant moment of inertia below that frequency.
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| 36. |
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| 37. |
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| 38. |
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| 39. |
- Gencer, S, et al.
(författare)
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Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium
- 2022
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Ingår i: Basic research in cardiology. - : Springer Science and Business Media LLC. - 1435-1803 .- 0300-8428. ; 117:1, s. 30-
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Tidskriftsartikel (refereegranskat)abstract
- Atherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a large residual risk; therefore, novel therapeutic candidates targeting inflammation are needed. The endothelium is the starting point of vascular inflammation underlying atherosclerosis and we could previously demonstrate that the chemokine axis CXCL12–CXCR4 plays an important role in disease development. However, the role of ACKR3, the alternative and higher affinity receptor for CXCL12 remained to be elucidated. We studied the role of arterial ACKR3 in atherosclerosis using western diet-fed Apoe−/− mice lacking Ackr3 in arterial endothelial as well as smooth muscle cells. We show for the first time that arterial endothelial deficiency of ACKR3 attenuates atherosclerosis as a result of diminished arterial adhesion as well as invasion of immune cells. ACKR3 silencing in inflamed human coronary artery endothelial cells decreased adhesion molecule expression, establishing an initial human validation of ACKR3’s role in endothelial adhesion. Concomitantly, ACKR3 silencing downregulated key mediators in the MAPK pathway, such as ERK1/2, as well as the phosphorylation of the NF-kB p65 subunit. Endothelial cells in atherosclerotic lesions also revealed decreased phospho-NF-kB p65 expression in ACKR3-deficient mice. Lack of smooth muscle cell-specific as well as hematopoietic ACKR3 did not impact atherosclerosis in mice. Collectively, our findings indicate that arterial endothelial ACKR3 fuels atherosclerosis by mediating endothelium-immune cell adhesion, most likely through inflammatory MAPK and NF-kB pathways.
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| 40. |
- Huth, Cornelia, et al.
(författare)
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IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
- 2006
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Ingår i: DIABETES. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:10, s. 2915-2921
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Tidskriftsartikel (refereegranskat)abstract
- Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, −174G>C (rs1800795) and −573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 −174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 −573G>C and type 2 diabetes. The observed association of the IL6 −174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
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| 41. |
- JIN, HQ, et al.
(författare)
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IDENTIFICATION AND QUADRUPOLE-MOMENT MEASUREMENT OF A SUPERDEFORMED BAND IN ZR-84
- 1995
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 75:8, s. 1471-1474
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Zr-84 were studied using the early implementation phase of the Gammasphere array and the ''Microball'' charged-particle detector system. A cascade of nine gamma rays with a dynamic moment of inertia which is characteristic of superdeformed rotational bands in the A = 80 region has been identified and assigned to Zr-84. The measured transition quadrupole moment of the band corresponds to a prolate quadrupole deformation of beta(2) = 0.53 and confirms the superdeformed nature of this band. This is the first direct experimental confirmation of the existence of the predicted superdeformed shell gap at N similar or equal to 44 particle number.
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| 42. |
- LAFOSSE, DR, et al.
(författare)
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CHARACTERIZATION OF THE FIRST SUPERDEFORMED BAND IN THE A-APPROXIMATE-TO-80 REGION
- 1995
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Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 354:1-2, s. 34-40
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Tidskriftsartikel (refereegranskat)abstract
- The recently discovered superdeformed band in one of the strontium isotopes has been identified as belonging to Sr-83 from a study with the Gammasphere array and the Microball charged-particle detector system. From its decay pattern, a spin of (81 +/- 2)/2 ($) over bar h is deduced for the highest level of this band. Evidence for very fast transition rates and agreement of the characteristics of this band with the theoretical predictions establish the yrast superdeformed nature of this band in Sr-83.
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- Wiedeking, M., et al.
(författare)
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Transition strengths and band terminations in 86Zr
- 2003
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Ingår i: Physical Review C - Nuclear Physics. - 0556-2813. ; 67, s. 1-034320
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Tidskriftsartikel (refereegranskat)abstract
- High angular momentum states in 86Zr were populated through the 58Ni(32S,4p) reaction at 135 MeV using the 88-In. Cyclotron at Lawrence Berkeley National Laboratory. Recoiling 86Zr nuclei were stopped in a thick Ta backing. Prompt multi-γ coincidences with evaporated charged particles were detected using the full array of GAMMASPHERE and the MICROBALL. Mean lifetimes of 36 levels in 86Zr were measured using the Doppler-shift attenuation method. Transition quadrupole moments Qt were found in the range of about 0.3-1.5 e b in the positive-parity bands. The negative-parity bands show Qt values from about 0.25 to 1.2 e b. In the yrast positive-parity band, a sharp drop in collectivity approaching the 30+ state supports the interpretation of band termination in this configuration. Decreasing Qt values approaching the 24+ and 27- states also provide an indication of terminating structures.
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