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- Johansson, Ulf, et al.
(författare)
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Mining trackman golf data
- 2016
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Ingår i: Proceedings - 2015 International Conference on Computational Science and Computational Intelligence, CSCI 2015. - Los Alamitos, CA : IEEE. - 9781467397957 ; , s. 380-385
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Konferensbidrag (refereegranskat)abstract
- Recently, innovative technology like Trackman has made it possible to generate data describing golf swings. In this application paper, we analyze Trackman data from 275 golfers using descriptive statistics and machine learning techniques. The overall goal is to find non-trivial and general patterns in the data that can be used to identify and explain what separates skilled golfers from poor. Experimental results show that random forest models, generated from Trackman data, were able to predict the handicap of a golfer, with a performance comparable to human experts. Based on interpretable predictive models, descriptive statistics and correlation analysis, the most distinguishing property of better golfers is their consistency. In addition, the analysis shows that better players have superior control of the club head at impact and generally hit the ball straighter. A very interesting finding is that better players also tend to swing flatter. Finally, an outright comparison between data describing the club head movement and ball flight data, indicates that a majority of golfers do not hit the ball solid enough for the basic golf theory to apply.
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- Kotrschal, Alexander, et al.
(författare)
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Artificial Selection on Relative Brain Size Reveals a Positive Genetic Correlation Between Brain Size and Proactive Personality in the Guppy
- 2014
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Ingår i: Evolution. - : Wiley. - 0014-3820 .- 1558-5646. ; 68:4, s. 1139-1149
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Tidskriftsartikel (refereegranskat)abstract
- Animal personalities range from individuals that are shy, cautious, and easily stressed (a "reactive" personality type) to individuals that are bold, innovative, and quick to learn novel tasks, but also prone to routine formation (a "proactive" personality type). Although personality differences should have important consequences for fitness, their underlying mechanisms remain poorly understood. Here, we investigated how genetic variation in brain size affects personality. We put selection lines of large- and small-brained guppies (Poecilia reticulata), with known differences in cognitive ability, through three standard personality assays. First, we found that large-brained animals were faster to habituate to, and more exploratory in, open field tests. Large-brained females were also bolder. Second, large-brained animals excreted less cortisol in a stressful situation (confinement). Third, large-brained animals were slower to feed from a novel food source, which we interpret as being caused by reduced behavioral flexibility rather than lack of innovation in the large-brained lines. Overall, the results point toward a more proactive personality type in large-brained animals. Thus, this study provides the first experimental evidence linking brain size and personality, an interaction that may affect important fitness-related aspects of ecology such as dispersal and niche exploration.
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- Schachtl, M., et al.
(författare)
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Experiences with "dithionite Based Additives (DBA) in (C)TMP" in lab, pilot and mill scale : Synergies between high brightness, less specific energy consumption and development of pulp properties
- 2016
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Ingår i: International Mechanical Pulping Conference 2016 (IMPC 2016). - : TAPPI Press. - 9781510830738 ; , s. 59-69
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of this paper is to report about our experiences with treating softwood mechanical pulp (MP) with DBA directly injected into the gap of high consistency (HC) refiners used as chemical reactors to improve the competitiveness and the ecological footprint of (C)TMP based products. After the description of the main factors and pros and cons of conventional oxidative and reductive bleaching of sofhvood MP the basic principles of the treatment of MP with DBA in the (C)TMP refiner are outlined. By means of exemplary results of trials in lab, pilot and mill scale as well as of productions the main advantages of "DBA in (C)TMP" are illustrated: efficient brightness gain, reduction of anionic trash, high wood yield, reduction of hard chelating agents, saving of refining energy and increase of strength properties. Using the example of Norske Skog Skogn it is demonstrated how the system works in practice in the production of high bright and standard newsprint made from normal and lower quality wood. Finally it is pointed out that to a certain extent DBAs can be tailored to the needs of the respective mill.
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- Stuparu, Andreea D., et al.
(författare)
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Mechanisms of Resistance to Prostate-Specific Membrane Antigen-Targeted Radioligand Therapy in a Mouse Model of Prostate Cancer
- 2021
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Ingår i: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505. ; 62:7, s. 989-995
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Tidskriftsartikel (refereegranskat)abstract
- Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is effective against prostate cancer (PCa), but all patients relapse eventually. Poor understanding of the underlying resistance mechanisms represents a key barrier to development of more effective RLT. We investigate the proteome and phosphoproteome in a mouse model of PCa to identify signaling adaptations triggered by PSMA RLT. Methods: Therapeutic efficacy of PSMA RLT was assessed by tumor volume measurements, time to progression, and survival in C4-2 or C4-2 TP53-/- tumor-bearing nonobese diabetic scid γ-mice. Two days after RLT, the proteome and phosphoproteome were analyzed by mass spectrometry. Results: PSMA RLT significantly improved disease control in a dose-dependent manner. Proteome and phosphoproteome datasets revealed activation of genotoxic stress response pathways, including deregulation of DNA damage/replication stress response, TP53, androgen receptor, phosphatidylinositol-3-kinase/AKT, and MYC signaling. C4-2 TP53-/- tumors were less sensitive to PSMA RLT than were parental counterparts, supporting a role for TP53 in mediating RLT responsiveness. Conclusion: We identified signaling alterations that may mediate resistance to PSMA RLT in a PCa mouse model. Our data enable the development of rational synergistic RLT-combination therapies to improve outcomes for PCa patients.
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