SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Dahlin Christer 1959) "

Sökning: WFRF:(Dahlin Christer 1959)

  • Resultat 1-50 av 74
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Aludden, H., et al. (författare)
  • Histomorphometric analyses of area fraction of different ratios of Bio-Oss((R)) and bone prior to grafting procedures - An in vitro study to demonstrate a baseline
  • 2018
  • Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 29:2, s. 185-191
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectiveThe objective of this study was to estimate the area fraction of different ratios of Bio-Oss((R)) and bone, prior to grafting in an in vitro model to demonstrate a histomorphometric baseline. MethodsBio-Oss((R)) particles were mixed with autogenous bone from pig jaw in three different ratios (50:50, 80:20 and 100:0) and packed in rice paper in a standardized procedure. Histomorphometric analyses were performed in 25 specimens and 74 regions of interest. The area percentage of Bio-Oss((R)), bone, and non-mineralized tissue (NMT) were calculated. Results were reported as mean values and 95% confidence interval (CI). ResultsThe mean area fraction of Bio-Oss((R)) was 20.6% (CI: 18.2-23) in the 50:50 mixture, 33.6% (CI: 29.7-37.6) in the 80:20 mixture, and 43.4% (CI: 40.5-46.3) in the 100:0 mixture. The mean area fraction of NMT was 60.5% (CI: 57.9-63.1) in the 50:50 mixture, 59.6% (CI: 56.4-62.7) in the 80:20 mixture, and 56.6% (CI: 53.7-59.5) in the 100:0 mixture. The mean area fraction of bone was 18.9% (CI: 16.9-20.9) in the 50:50 mixture and 6.8% (CI: 5-8.6) in the 80:20 mixture. ConclusionThere is a great difference in the clinically estimated percentage and the histomorphometrically evaluated percentage of Bio-Oss((R)) at baseline, prior to grafting. The area fraction of different tissues presented in this study may be beneficial as guidance for histomorphometrical baseline calculations when different mixtures of Bio-Oss((R)) and autogenous bone are used as grafting materials.
  •  
2.
  • Farzad, Payam, 1973, et al. (författare)
  • Integration of dental implants in conjunction with edta-conditioned dentin grafts: An experimental study
  • 2021
  • Ingår i: Dentistry Journal. - : MDPI AG. - 2304-6767. ; 9:6
  • Tidskriftsartikel (refereegranskat)abstract
    • This study was undertaken to investigate the integration of titanium micro-implants installed in conjunction with previously dentin-grafted areas and to study the morphological appearance, mineral content, and healing pattern of xenogenic EDTA-conditioned dentin blocks and granules grafted to cavities in the tibial bone of rabbits. Demineralized and non-demineralized dentin blocks and granules from human premolars were implanted into cavities prepared on the lateral aspects of the tibias of rabbits. After a healing period of six months, micro-implants were installed at each surgical site. Histological examinations were carried out after 24 weeks. Characterization of the EDTA-conditioned dentin blocks was performed by means of light microscopy, dental X-rays, scanning electron microscopy, and energy dispersive X-ray analysis (EDX). No implants were found to be integrated in direct contact with the dentin particles or blocks. On the EDTA-conditioned dentin surface, the organic marker elements C and N dominated, as revealed by EDX. The hydroxyapatite constituents Ca and P were almost absent on the dentin surface. No statistically significant difference was observed between the EDTA-conditioned and non-demineralized dentin, as revealed by BIC and BA. The bone-inductive capacity of the dentin material seemed limited, although demineralization by means of EDTA indicated higher BIC and BA values in conjunction with the installed implants in the area. A 12 h EDTA treatment did not fully decalcify the grafts, as revealed by X-ray analysis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
  •  
3.
  • Omar, Omar, et al. (författare)
  • Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration: A preclinical molecular and histological study in vivo
  • 2018
  • Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161. ; 29:1, s. 7-19
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: To investigate the molecular and structural patterns of bone healing during guided bone regeneration (GBR), comparing two resorbable non-cross-linked collagen membranes. Materials and methods: Trabecular bone defects in rat femurs were filled with deproteinized bovine bone (DBB) and covered with either a membrane comprising collagen and elastin (CXP) or collagen (BG). Samples were harvested after 3 and 21 days for histology/histomorphometry and gene expression analysis. Gene expression analysis was performed on the membrane (at 3 days) and the underlying defect compartment (at 3 and 21 days). Results: At the total defect level, no differences in bone area percentage were found between the CXP and BG. When evaluating the central area of the defect, a higher percentage of de novo bone formation was seen for the CXP membrane (34.9%) compared to BG (15.5%) at 21 days (p = .01). Gene expression analysis revealed higher expression of bone morphogenetic protein-2 (Bmp2) in the membrane compartment at 3 days in the BG group. By contrast, higher Bmp2 expression was found in the defect compartment treated with the CXP membrane, both at 3 and 21 days. A significant temporal increase (from 3 to 21 days) in the remodeling activity, cathepsin K (Catk) and calcitonin receptor (Calcr), was found in the CXP group. Molecular analysis demonstrated expression of several growth factors and cytokines in the membrane compartment irrespective of the membrane type. Bmp2 expression in the membrane correlated positively with Bmp2 expression in the defect, whereas fibroblast growth factor-2 (Fgf2) expression in the membrane correlated positively with inflammatory cytokines, tumor necrosis factor-alpha (Tnfa) and interleukin-6 (II6) in the defect. Conclusions: The results provide histological and molecular evidence that different resorbable collagen membranes contribute differently to the GBR healing process. In the BG group, bone formation was primarily localized to the peripheral part of the defect. By contrast, the CXP group demonstrated significantly higher de novo bone formation in the central portion of the defect. This increase in bone formation was reflected by triggered expression of potent osteogenic growth factor, Bmp2, in the defect. These findings suggest that the CXP membrane may have a more active role in regulating the bone healing dynamics.
  •  
4.
  •  
5.
  • Al-Asfour, Adel, et al. (författare)
  • Demineralized Xenogenic Dentin and Autogenous Bone as Onlay Grafts to Rabbit Tibia.
  • 2017
  • Ingår i: Implant dentistry. - 1538-2982. ; 26:2, s. 232-237
  • Tidskriftsartikel (refereegranskat)abstract
    • The present study was undertaken to evaluate the healing pattern of xenogenic demineralized dentin onlay grafts in comparison with autogenous bone grafts to the rabbit tibia.Eight 6-month-old New Zealand male rabbits were used in the experiments. Standardized sized dentin blocks from human premolars and similar autogenous bone blocks harvested from tibia were grafted as onlay blocks on each tibia (n = 8 × 2). All animals were killed after a healing period of 12 weeks.Healing was uneventful for all animals. In general, both the dentin and bone block grafts were fused to the bone, resorbed, and replaced by bone and connective tissue to a varying degree. Both types of grafts were still present after 12 weeks, on an average to approximately one third of the original sizes. Resorption cavities could be seen in the dentin with bone formation. Zones of osseous replacement resorption of the dentin could be noted. In both graft types, higher rate of bone formation was seen at the interface between graft and recipient site.Demineralized xenogenic dentin onlay grafts showed similar resorption characteristics as autogenous bone onlay grafts, being resorbed in a similar rate during 12 weeks. New bone formation occurred mainly in terms of replacement resorption in the interface between dentin/bone graft and native bone.
  •  
6.
  • Al-Asfour, Adel, et al. (författare)
  • Histologic analysis of a novel extracellullar matrix membrane for guided bone regeneration: an experimental study in rabbits.
  • 2013
  • Ingår i: The International journal of periodontics & restorative dentistry. - : Quintessence Publishing. - 1945-3388 .- 0198-7569. ; 33:2, s. 177-83
  • Tidskriftsartikel (refereegranskat)abstract
    • This experiment was conducted to study the histologic feasibility and biologic impact of Ti02 impregnation of an extracellullar matrix (ECM) membrane in guided bone regeneration. Eighteen adult New Zealand White rabbits were used. Bilateral bone defects were created in edentulous areas of the maxilla. The defects were filled with demineralized freeze-dried bone (DFDB). ECM was randomly pretreated with a suspension containing saline and 3 mg Ti02 granules. A regular ECM membrane served as a control on the contralateral side. Healing periods were 2, 4, and 8 weeks. Histologic and histomorphometric analyses were performed. The parameters assessed were (1) zone of inflammatory cells adjacent to ECM membrane, (2) presence of cellullar ingrowth into ECM, and (3) presence of Ti02 particles within the ECM barrier membrane. In general, no adverse reactions toward both groups of ECM membranes could be noted. The Ti02 particles remained within the ECM after 8 weeks of healing, making histologic detection of ECM easy. Histomorphometric analysis revealed low numbers of inflammatory cells adjacent to the ECM surface and adequate preservation and integration of the barrier. Contrasting Ti02 particles impregnated into the ECM membrane can be a very useful tool for the detection of similar biologic materials in in vivo models.
  •  
7.
  • Al-Asfour, Adel, et al. (författare)
  • Host tissue reactions of non-demineralized autogenic and xenogenic dentin blocks implanted in a non-osteogenic environment. An experimental study in rabbits.
  • 2014
  • Ingår i: Dental traumatology : official publication of International Association for Dental Traumatology. - : Wiley. - 1600-9657. ; 30:3, s. 198-203
  • Tidskriftsartikel (refereegranskat)abstract
    • Dentoalveolar ankylosis with osseous replacement is often seen after replantation of avulsed teeth, and this process may be used for preservation of alveolar crests after trauma. Its exact mechanisms with regard to osteoinductive properties are not yet fully understood and need to be systematically investigated. Dentin can possibly act as a slow-releasing carrier of bone morphogenic proteins (BMP), and this property of dentin has been proposed to be used as an alternative or supplement to bone grafting in the maxillofacial region. We aimed to initially asses host tissue reactions to dentin by implanting dentin blocks of autogenic and xenogenic human origin in rabbit connective tissue of the abdominal wall and femoral muscle. Animals were sacrificed after a period of 3months, and histological processing, sectioning and examinations were carried out. Bone formation, cell counts and thickness of capsule surrounding the grafts were evaluated. Only minor signs of heterotopic bone formation were seen. There were no significant differences between autografts and xenografts or grafts implanted in connective tissue or muscle with regards to tissue reactions except for a significant difference (P=0.018) in findings of more local inflammatory cells in relation to grafts placed in connective tissue in the autograft group. We conclude that during the time frame of this study, non-demineralized dentin, whether autogenous or xenogenic did not have the potential to induce bone formation when implanted in non-osteogenic areas such as the abdominal wall and abdominal muscle of rabbits.
  •  
8.
  • Albrektsson, Tomas, 1945, et al. (författare)
  • An Imbalance of the Immune System Instead of a Disease Behind Marginal Bone Loss Around Oral Implants: Position Paper
  • 2020
  • Ingår i: The International journal of oral & maxillofacial implants. - : Quintessence Publishing. - 1942-4434 .- 0882-2786. ; 35:3, s. 495-502
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The purpose of this paper is to present evidence that supports the notion that the primary reason behind marginal bone loss and implant failure is immune-based and that bacterial actions in the great majority of problematic cases are of a secondary nature. MATERIALS AND METHODS: The paper is written as a narrative review. RESULTS: Evidence is presented that commercially pure titanium is not biologically inert, but instead activates the innate immune system of the body. For its function, the clinical implant is dependent on an immune/inflammatory defense against bacteria. Biologic models such as ligature studies have incorrectly assumed that the primary response causing marginal bone loss is due to bacterial action. In reality, bacterial actions are secondary to an imbalance of the innate immune system caused by the combination of titanium implants and ligatures, ie, nonself. This immunologic imbalance may lead to marginal bone resorption even in the absence of bacteria. CONCLUSION: Marginal bone loss and imminent oral implant failure cannot be properly analyzed without a clear understanding of immunologically caused tissue responses.
  •  
9.
  • Albrektsson, Tomas, et al. (författare)
  • Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?
  • 2014
  • Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 16:2, s. 155-165
  • Tidskriftsartikel (refereegranskat)abstract
    • Background When a foreign body is placed in bone or soft tissue, an inflammatory reaction inevitably develops. Hence, osseointegration is but a foreign body response to the implant, which according to classic pathology is a chronic inflammatory response and characterized by bone embedding/separation of the implant from the body. Purpose The aim of this paper is to suggest an alternative way of looking at the reason for marginal bone loss as a complication to treatment rather than a disease process. Materials and Methods The present paper is authored as a narrative review contribution. Results The implant-enveloping bone has sparse blood circulation and is lacking proper innervation in clear contrast to natural teeth that are anchored in bone by a periodontal ligament rich in blood vessels and nerves. Fortunately, a balanced, steady state situation of the inevitable foreign body response will be established for the great majority of implants, seen as maintained osseointegration with no or only very little marginal bone loss. Marginal bone resorption around the implant is the result of different tissue reactions coupled to the foreign body response and is not primarily related to biofilm-mediated infectious processes as in the pathogenesis of periodontitis around teeth. This means that initial marginal bone resorption around implants represents a reaction to treatment and is not at all a disease process. There is clear evidence that the initial foreign body response to the implant can be sustained and aggravated by various factors related to implant hardware, patient characteristics, surgical and/or prosthodontic mishaps, which may lead to significant marginal bone loss and possibly to implant failure. Admittedly, once severe marginal bone loss has developed, a secondary biofilm-mediated infection may follow as a complication to the already established bone loss. Conclusions The present authors regard researchers seeing marginal bone loss as a periodontitis-like disease to be on the wrong track; the onset of marginal bone loss around oral implants depends in reality on a dis-balanced foreign body response.
  •  
10.
  • Aludden, H. C., et al. (författare)
  • Lateral ridge augmentation with Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone graft: a systematic review
  • 2017
  • Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027. ; 46:8, s. 1030-1038
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this systematic review was to test the hypothesis of no difference in implant treatment outcomes when using Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone grafts for lateral ridge augmentation. A search of the MEDLINE, Cochrane Library, and Embase databases in combination with a hand-search of relevant journals was conducted. Human studies published in English from 1 January 1990 to 1 May 2016 were included. The search provided 337 titles and six studies fulfilled the inclusion criteria. Considerable variation prevented a meta-analysis from being performed. The two treatment modalities have never been compared within the same study. Non-comparative studies demonstrated a 3-year implant survival of 96% with 50% Bio-Oss mixed with 50% autogenous bone graft. Moreover, Bio-Oss alone or Bio-Oss mixed with autogenous bone graft seems to increase the amount of newly formed bone as well as the width of the alveolar process. Within the limitations of this systematic review, lateral ridge augmentation with Bio-Oss alone or in combination with autogenous bone graft seems to induce newly formed bone and increase the width of the alveolar process, with high short-term implant survival. However, long-term studies comparing the two treatment modalities are needed before final conclusions can be drawn.
  •  
11.
  • Aludden, Hanna, et al. (författare)
  • Histological and histomorphometrical outcome after lateral guided bone regeneration augmentation of the mandible with different ratios of deproteinized bovine bone mineral and autogenous bone. A preclinical in vivo study
  • 2020
  • Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 31:10, s. 1025-1036
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Objective: To test the hypotheses of no differences in (I) percentage of bone (POB), non-mineralized tissue (NMT), and deproteinized bovine bone mineral (DBBM), and (II) ingrowth of mineralized bone after lateral guided bone regeneration (GBR) augmentation of the mandible with different ratios of DBBM and particulate autogenous bone (PAB) at different time points. Material and methods: Twenty-four minipigs were randomly allocated into three groups. Lateral augmentation in 96 sites (4 in each animal) was performed unilaterally with a standardized quantity of grafting material in each animal with different ratios of DBBM and PAB (50:50, 75:25, 100:0) and autogenous bone block in combination with DBBM and covered with a collagen membrane. The percentage of different tissues in the graft and ingrowth of mineralized bone was assessed by histomorphometrical and histological analyses after 10, 20, and 30weeks, respectively. Results: The POB was 54% (50:50), 50% (75:25), and 48% (100:0) after 10weeks, 60% (50:50), 61% (75:25), and 60% (100:0) after 20weeks, and 63% (50:50), 62% (75:25), and 62% (100:0) after 30weeks. There was no significant difference between the groups at any time points. There was a significant increase in POB and a significant decrease in NMT for 75:25 and 100:0 from 10 to 30weeks. All ratios demonstrated a non-complete ingrowth of mineralized bone into the graft after 10weeks and complete mineralization after 30weeks. Conclusion: Within the limitations of the present study, it seems like addition of autogenous bone to DBBM for LRA did not affect the bone formation nor graft incorporation after 10–30weeks of healing. However, a prolonged healing time seems to result in an increased POB for all ratios.
  •  
12.
  • Aludden, Hanna, 1984, et al. (författare)
  • Histological and radiological outcome after horizontal guided bone regeneration with bovine bone mineral alone or in combination with bone in edentulous atrophic maxilla: A randomized controlled trial
  • 2024
  • Ingår i: CLINICAL ORAL IMPLANTS RESEARCH. - 0905-7161 .- 1600-0501.
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectiveTo assess the radiological and histological outcome after horizontal guided bone regeneration (GBR) with deproteinized bovine bone mineral (DBBM) alone or in combination with particulate autogenous bone (PAB).Materials and MethodsEighteen edentulous patients with an alveolar ridge of <= 4 mm were included in this split-mouth randomized controlled trial. Horizontal GBR with a graft composition of 100% DBBM (100:0) on one side and 90% DBBM and 10% PAB (90:10) on the other side were conducted in all patients. Cone beam computed tomography (CBCT) was obtained preoperatively, immediately postoperative, and after 10 months of healing. Width and volumetric changes in the alveolar process were measured on CBCT. Implants were placed after 10 months of graft healing where biopsies were obtained for histomorphometrical evaluation.ResultsThe gained widths were 4.9 (+/- 2.4) mm (100:0) and 4.5 (+/- 2.0) mm (90:10) at 3 mm from the top of the crest, and 5.6 (+/- 1.3) mm (100:0) and 4.6 (+/- 2.1) mm (90:10) at 6 mm from the top of the crest. The mean volumetric reductions were 32.8% (+/- 23.8) (100:0) and 38.2% (+/- 23.2) (90:10). Histomorphometry revealed that mean percentages of bone were 50.8% (+/- 10.7) (100:0) and 46.4% (+/- 11.3) (90:10), DBBM were 31.6% (+/- 12.6) (100:0) and 35.4% (+/- 14.8) (90:10), and non-mineralized tissue were 17.6% (+/- 11.7; 100:0) and 18.2% (+/- 18.2) (90:10). No significant differences were evident between in any evaluated parameters.ConclusionsThere were no additional effects of adding PAB to DBBM regarding bone formation, width changes, or volumetric changes after 10 months of graft healing.
  •  
13.
  • Aludden, H., et al. (författare)
  • Radiographic changes in height and volume after lateral GBR procedures with different ratios of deproteinized bovine bone mineral and autogenous bone at different time points. An experimental study
  • 2021
  • Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 32:2, s. 167-179
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective Estimate changes in augmentation height and volume after lateral guided bone regeneration (GBR) augmentation with different ratios of deproteinized bovine bone mineral (DBBM) and particulate autogenous bone (PAB) and autogenous bone block (ABB), at different time points. Material and methods Twenty-four minipigs were randomly allocated into three healing periods. Lateral augmentation in 96 sites with standardized quantity of graft material was performed with different ratios of DBBM and PAB (50:50, 75:25, and 100:0) and ABB in combination with DBBM, covered by a collagen membrane. Changes in augmentation height and volume were assessed on CT volumes acquired 10, 20, and 30 weeks after surgery. Results Reduction in bone augmentation height was as follows: 50:50-1.7 mm (-33.1%), 75:25-1.8 mm (-37.8%), 100:0-1.7 mm (-35.8%), and ABB - 0.2 mm (-3.7%), after 30 weeks. The augmentation height was significantly better preserved with ABB compared to 50:50, 75:25, and 100:0, while no significant difference was present among particulate grafts. No significant difference in volumetric reduction was found among 50:50, 75:25, 100:0 and ABB after 30 weeks, while 100:0 presented significant less reduction compared to 50:50, 75:25 and ABB after 10 and 20 weeks. Conclusions Augmentation height following GBR was better preserved with ABB covered with DBBM. Addition of PAB to DBBM did not affect the changes in height of the graft. The volumetric stability seems to be comparable for ABB covered by DBBM and all particulate grafts after 30 weeks. However, DBBM alone revealed significant less volume reduction in the early healing phase.
  •  
14.
  • Asa'ad, Farah, 1983, et al. (författare)
  • Expression of MicroRNAs in Periodontal and Peri-Implant Diseases: A Systematic Review and Meta-Analysis.
  • 2020
  • Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 21:11
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this review was to evaluate the expression patterns of miRNAs in periodontal and peri-implant diseases, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker.Human and animal studies were included when evaluating expression of miRNAs between health and different forms/stages of diseases, in which microarray and/or real-time polymerase chain reaction (RT-PCR) was carried out to detect fold changes in gene expression. After full-text analysis, 43 articles were considered for a qualitative assessment, and 16 miRNAs were selected to perform meta-analysis.Based on human studies, results showed an overall upregulation of most of the evaluated miRNAs in periodontitis, with miRNA-142-3p and miRNA-146a being the most conclusive on both microarray and RT-PCR values and potentially serving as diagnostic biomarkers for disease activity. Conversely, miR-155 was the only miRNA revealing a statistically significant difference (SSD) (p < 0.05*) in experimental periodontitis models from RT-PCR values. Scarce scientific evidence is available from peri-implant diseases, however, most explored miRNAs in peri-implantitis were downregulated except for miR-145.Although our results revealed that a distinct differential expression of specific miRNAs can be noted between the state of health and disease, future research remains necessary to explore the functional role of specific miRNAs and their potential as therapeutic targets in periodontal and peri-implant diseases. MeSH Terms: periodontitis, peri-implantitis, epigenomics, microarray analysis, real-time polymerase chain reaction, microRNAs.Scientific background: Although most research identified different expression levels of miRNAs in periodontal and peri-implant diseases compared to their counterparts, their actual role in the pathogenesis of these conditions remains unclear. Therefore, we aimed to present a systematic review and meta-analysis on the expression patterns of miRNAs in periodontitis and peri-implantitis, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker.In periodontitis-related studies, miRNA-142-3p and miRNA-146a were the most conclusive on both microarray and RT-PCR values. Scarce scientific evidence is available from peri-implant diseases.Both miRNA-142-3p and miRNA-146a might serve as future diagnostic biomarkers for disease activity in periodontitis. Yet, future research remains necessary to explore the functional role of specific miRNAs and their potential as therapeutic targets in periodontal and peri-implant diseases.
  •  
15.
  • Asa'ad, Farah, 1983, et al. (författare)
  • The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration-A Review.
  • 2020
  • Ingår i: Molecules (Basel, Switzerland). - : MDPI AG. - 1420-3049. ; 25:24
  • Tidskriftsartikel (refereegranskat)abstract
    • The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better tissue regeneration? Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.
  •  
16.
  • Becker, W, et al. (författare)
  • Five-year evaluation of implants placed at extraction and with dehiscences and fenestration defects augmented with ePTFE membranes: results from a prospective multicenter study.
  • 1999
  • Ingår i: Clinical implant dentistry and related research. - 1523-0899. ; 1:1, s. 27-32
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Barrier membranes have been used to promote bone ingrowth on implants with dehiscences and fenestrations. Membranes also have been used to protect defects adjacent to implants placed at the time of extraction. The concept of guided bone regeneration relates to preferentially allowing cells from bone to migrate into various defects while excluding fibrous tissue and epithelium. The purpose of these procedures is to enhance bone-to-implant contact at the treated sites and to prevent mucosal complications. PURPOSE: The purpose of this article is to report clinical outcomes for implants placed at the time of extraction and augmented with expanded polytetrafluoroethylene (ePTFE) and followed for 5 years. The outcomes for implants with dehiscences and fenestrations augmented with ePTFE barriers and followed up to 5 years also are reported. METHODS AND MATERIALS: Four treatment centers participated in this study (Tucson, Gothenburg, Spokane, and Leuven). In the extraction group, teeth were removed for varying reasons, and Br?nemark implants were placed and stabilized within the host bone. Defects present at the coronal implant aspect were covered with ePTFE barrier membranes. Flaps were rotated to cover the membrane-treated sites. If exposure of the material occurred prior to second-stage surgery, the membranes were removed. Barriers remaining unexposed were removed at second-stage surgery. The implants were followed up to 5 years. In the fenestration and dehiscence group, implants with exposed threads were augmented with ePTFE barrier membranes. The barriers were removed at appropriate intervals, and the patients were followed up to 5 years. Radiographic measurements were made from nonstandardized periapical radiographs at abutment connection and 1, 3, and 5-year follow-up visits. RESULTS: Forty patients participated in the extraction group. They received a total of 49 implants. Three implants failed prior to loading. The 5-year cumulative survival rates for implants placed at the time of extraction were 93.9% and 93.8%, respectively, for maxillary and mandibular implants. The average maxillary mesial and distal marginal bone loss (1-5 yr) was 0.3 mm (standard deviation [SD] = 1.5) and 0.3 mm (SD = 1.0). In mandibles, the average mesial and distal bone loss (1-5 yr) was -0.2 mm (SD = 0.5) and -0.05 mm (SD = 0.6), respectively. The dehiscence and fenestration group included 44 patients. Twenty-six were followed for up to 5 years. Eight patients experienced total implant failure. For dehiscences and fenestrations, the cumulative survival rates were 76.8% and 83.8% for maxillary and mandibular implants, respectively. The average maxillary mesial and distal bone loss (1-5 yr) was 0.4 mm (SD = 0.8) and 0.2 mm (SD = 0.9), respectively. In mandibles, the average mesial and distal marginal bone loss was 0.3 mm (SD = 0.9) and 0.3 mm (SD = 0.8), respectively. CONCLUSIONS: Implants placed at the time of extraction and augmented with ePTFE barrier membranes have favorable long-term predictability. On the other hand, long-term evaluation of implant dehiscences and fenestrations augmented with barrier membranes indicates that they have less favorable 5-year survival rates. Membrane augmentation of these may be questioned.
  •  
17.
  • Berglund, Malin, 1970, et al. (författare)
  • Hearing outcome after myringoplasty in Sweden: A nationwide registry-based cohort study
  • 2020
  • Ingår i: Clinical Otolaryngology. - : Wiley. - 1749-4478 .- 1749-4486 .- 1365-2273. ; 45:3, s. 357-363
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives To present hearing results after successful primary myringoplasty surgeries registered in the Swedish Quality Registry for Myringoplasty and to evaluate the chance of hearing improvement and the risk of hearing loss. Design A retrospective nationwide cohort study based on prospectively collected registry data between 2002 and 2012. Settings Registry data from secondary and tertiary hospitals performing myringoplasty. Participants Patients with healed tympanic membrane after primary myringoplasty surgery performed from 2002 to 2012 in Sweden. Main outcome measures Postoperative hearing results, hearing gain and air-bone gap (ABG). Results In 2226 myringoplasties, air conduction audiograms were recorded, and the average preoperative pure tone average (PTA(4)) of the group was 28.5 dB, which improved postoperatively to 19.6 dB with an average of 8.8 dB improvement. Bone conduction was measured for 1476 procedures. Closure of the ABG to 10 dB or less was achieved in 51% of the ears and to less than 20 dB in 89% of the ears. Sixty-one percent of patients with preoperatively deteriorated hearing experienced improved hearing, but 3% of all patients experienced deteriorated hearing. After the surgery, 93% of the patients were satisfied. Conclusions Hearing results after successful myringoplasty surgery are often favourable, but although the tympanic membrane is healed, hearing improvement is not guaranteed, and hearing deterioration can also occur.
  •  
18.
  • Buser, Daniel, et al. (författare)
  • Guided bone regeneration in implant dentistry: Basic principle, progress over 35 years, and recent research activities
  • 2023
  • Ingår i: Periodontology 2000. - 0906-6713 .- 1600-0757. ; 93:1, s. 9-25
  • Forskningsöversikt (refereegranskat)abstract
    • Bone augmentation procedures are frequent today in implant patients, since an implant should be circumferentially anchored in bone at completion of bone healing to have a good long-term stability. The best documented surgical technique to achieve this goal is guided bone regeneration (GBR) utilizing barrier membranes in combination with bone fillers. This clinical review paper reflects 35 years of development and progress with GBR. In the 1990s, GBR was developed by defining the indications for GBR, examining various barrier membranes, bone grafts, and bone substitutes. Complications were identified and reduced by modifications of the surgical technique. Today, the selection criteria for various surgical approaches are much better understood, in particular, in post-extraction implant placement. In the majority of patients, biodegradable collagen membranes are used, mainly for horizontal bone augmentation, whereas bioinert PTFE membranes are preferred for vertical ridge augmentation. The leading surgeons are using a composite graft with autogenous bone chips to accelerate bone formation, in combination with a low-substitution bone filer to better maintain the augmented bone volume over time. In addition, major efforts have been made since the millenium change to reduce surgical trauma and patient morbidity as much as possible. At the end, some open questions related to GBR are discussed.
  •  
19.
  • Cardemil, Carina, et al. (författare)
  • Influence of different operatory setups on implant survival rate: a retrospective clinical study
  • 2009
  • Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1708-8208 .- 1523-0899. ; 11:4, s. 288-291
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract BACKGROUND: Surgery performed under sterile operating conditions, as well as atraumatic surgery, has been stated to be among the most important requirements for successful osseointegration. However, there are few reports concerning the sterile surgical technique in association with implant placement, and the appropriate level of operatory setup is not fully known. PURPOSE: The purpose of this study was to analyze implant survival rate using a simplified surgical operatory setup compared with the use of the original Brånemark System (Nobel Biocare AB, Göteborg, Sweden) protocol. MATERIALS AND METHODS: A total of 1,285 consecutively treated patients were included in the study. Four thousand implants were placed during the period of 1985 to 2003. Group A (using the Brånemark System protocol) comprised of 654 patients and 2,414 implants. Group B (using a simplified operatory setup) comprised of 631 patients and 1,586 implants. Healing was evaluated after 6 months of clinical function. Failure was defined as the removal of implants because of nonosseointegration. Statistic analysis was performed using t-test for paired data. The level of significance was set at 5% for comparison of data. RESULTS: No significant difference with regard to complications and implant survival rate was found in the study. CONCLUSION: The result from the present study suggests that a simplified operatory setup does not affect the survival rate of oral implant treatment.
  •  
20.
  •  
21.
  • Dahlin, Christer, 1959, et al. (författare)
  • Apical peri-implantitis: possible predisposing factors, case reports, and surgical treatment suggestions.
  • 2009
  • Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899. ; 11:3, s. 222-7
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Apical peri-implantitis is often diagnosed by clinical findings such as pain, redness, tenderness, swelling, and sometimes the presence of a fistulous tract. There are few theories about how such a lesion occurs. Hence, the current clinical treatment protocols are scanty. PURPOSE: The aim of this report was to evaluate and confer a more extended surgical protocol and to discuss possible predisposing factors for the development of retrograde peri-implantitis. MATERIALS AND METHODS: Two patients were extensively evaluated with regard to clinical signs, implant treatment, postoperative complications, and surgical treatment. The surgical protocol comprised debridement, with the additional removal of the apical portion of the affected implant. Postoperative checkup included clinical examination and radiographs. The follow-up period ranged from 1 to 3 years following surgical debridement. The possible predisposing factors are also discussed in the article. RESULTS: Both cases healed uneventfully with no further symptoms. Radiographs revealed complete bone fill into the resected area and continuous stable bone levels around the previously affected implants. CONCLUSIONS: It is concluded that recommendations for treatment of apical peri-implantitis are still minimal. In the present study, a surgical approach with resection of the apical portion of the affected implants in combination with debridement is suggested. Our experience was that partially resected oral implants remain osseointegrated and also function well clinically with a follow-up period up to 3 years.
  •  
22.
  • Dahlin, Christer, 1959, et al. (författare)
  • Bone tissue modelling and remodelling following guided bone regeneration in combination with biphasic calcium phosphate materials presenting different microporosity
  • 2015
  • Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161. ; 26:7, s. 814-822
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to investigate bone regeneration following application of a novel biphasic calcium phosphate (BCP I) composed of microstructured granules of 90% β-tricalcium phosphate (β-TCP)/10% hydroxyapatite (HA) compared to BCP non-microstructured biphasic calcium phosphate with a composite of 60% hydroxyapatite/40% β-TCP (BCP II) and a deproteinized bovine bone mineral (DBBM) at surgically created defects in the mandible of minipigs in a combined approach with guided bone regeneration (GBR).
  •  
23.
  • Dahlin, Christer, 1959, et al. (författare)
  • Early biocompatibility of poly (ethylene glycol) hydrogel barrier materials for guided bone regeneration. An in vitro study using human gingival fibroblasts (HGF-1).
  • 2014
  • Ingår i: Clinical oral implants research. - : Wiley. - 1600-0501 .- 0905-7161. ; 25:1, s. 16-20
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: To evaluate the early cellular attachment and viability to modified polyethylene glycol (PEG) hydrogels with the influence of arginine-glycine-aspartic acid (RGD) in an in vitro model system. MATERIAL AND METHODS: Human gingival fibroblasts (HGF-1) were cultured on 6 different modalities of PEG hydrogel in hydrophobic polystyrene wells. A total of 7500cells/well (10000cells/cm(2) ) were dispersed over the PEG filled wells and incubated in triplicates for 24h, 7 and 13days. Cell numbers were calculated by means of a NucleoCounter. Cell viability was determined by measuring lactate dehydrogenase (LDH). For statistical analysis, nonparametric Kruska-Wallis test followed by Dunetts T3 test were used. RESULTS: All PEG modifications showed good biocompatibility, as demonstrated by low LDH values per cell at the earlier two time points. After 13days, all PEG modifications showed significantly lower number of cells compared with the controls, and the MX60 configurations demonstrated significantly higher LDH/cell values compared with the other hydrogels. CONCLUSIONS: Modifications of the physio-chemical properties of PEG hydrogels and the addition of RGD and spacers influenced the initial cellular response of cultured HGF-1 cells. With the exception of MX60 after 13days, all PEG formulations performed similarly well. Early cellular response should be considered when developing PEG-based material for clinical purposes.
  •  
24.
  • Dahlin, Christer, 1959, et al. (författare)
  • Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits.
  • 1989
  • Ingår i: The International journal of oral & maxillofacial implants. - 0882-2786. ; 4:1, s. 19-25
  • Tidskriftsartikel (refereegranskat)abstract
    • Insufficient bone volume may be a significant problem in connection with dental implants. In this study, a technique based on the principle of guided tissue regeneration was tested for its ability to generate bone tissue around titanium implants. Implants were inserted in tibiae of rabbits. To create a secluded space for osteogenesis and to prevent soft-tissue ingrowth, a porous Teflon membrane was placed around exposed parts of the implant. Where a membrane had been used, the threads of the implant were completely covered with significant amounts of new bone. This study indicates that the membrane technique is a reconstructive surgical method that may be applicable to create new bone around exposed parts of titanium implants in a clinical setting.
  •  
25.
  • Dahlin, Christer, 1959, et al. (författare)
  • Histological morphology of the e-PTFE/tissue interface in humans subjected to guided bone regeneration in conjunction with oral implant treatment.
  • 1998
  • Ingår i: Clinical oral implants research. - : Wiley. - 0905-7161. ; 9:2, s. 100-6
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of the present investigation was to study the histological morphology of the e-PTFE membrane/tissue interface in 5 humans subjected to GBR treatment in conjunction with oral implant treatment. Oral implants (Brånemark System) were inserted in extraction sockets 1 to 2 months after extraction of periodontally diseased teeth. The implants were placed approximately 2 mm below the surrounding bone margins. Specially designed 3 mm high cover-screws with horizontal slits for tissue ingrowth were applied to the implants and covered with e-PTFE membranes (GoreTex Augmentation Material). Re-entry was made 7 months later, except in 1 case where the membrane was removed 1 month postoperatively due to exposure and infection. In the remaining 4 sites, circular biopsies comprising membranes, tissues and cover-screws were retrieved. The specimens were fixated, processed and sectioned for light- and transmission electron microscopy. The space between the membrane and the cover-screw was occupied by fibrous tissue and varying amounts of bone. A cell- and vessel-rich fibrous tissue separated the bone from the membrane in the majority of the specimens. The membrane itself was penetrated by fibrous tissue. Fibroblasts and macrophages were the main cell types found in the fibrous tissue. The presence of irregularly shaped cells and unevenly distributed collagen fibres, indicated that the absence of bone formation may be due either to micromovements in the e-PTFE/tissue interface or to formation of fibrous tissue underneath the membrane by penetrating fibroblasts or a combination of these 2 phenomena.
  •  
26.
  • Dahlin, Christer, 1959, et al. (författare)
  • Iliac Crest Autogenous Bone Graft versus Alloplastic Graft and Guided Bone Regeneration in the Reconstruction of Atrophic Maxillae: A 5-Year Retrospective Study on Cost-Effectiveness and Clinical Outcome.
  • 2011
  • Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899. ; 13:4, s. 305-310
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Reconstruction of the atrophic maxillae with autogenous bone graft and jawbone-anchored bridges is a well-proven technique. However, the morbidity associated with the concept should not be neglected. Furthermore, the costs for such treatment, including general anesthesia and hospital stay, are significant. Little data are found in the literature with regard to a cost-benefit approach to various treatment alternates. Purpose: The aim of this retrospective study was to compare from a health-economical and clinical perspective the reconstruction of the atrophic maxillae prior to oral implant treatment either with autogenous bone grafts harvested from the iliac crest or the use of demineralized freeze-dried bone (DFDB) in combination with a thermoplastic carrier (Regeneration Technologies Inc., Alachua, FL, USA) and guided bone regeneration (GBR). Materials and Methods: A total of 26 patients (13+13) were selected and matched with regard to indication, sex, and age. The study was performed 5 years after the completion of the treatment. Implant survival, morbidity, and complications were analyzed. Furthermore, a detailed analysis of the total cost for the respective treatment modality was performed, including material, costs for staff, sick leave, etc. Results: The study revealed no statistical difference with regard to implant survival for the respective groups. The average total cost, per patient, for the DFDB group was 22.5% of the total cost for a patient treated with autogenous bone grafting procedures. Conclusions: The study concluded that reconstruction of atrophic maxillae with a bone substitute material (DFDB) in combination with GBR can be performed with an equal treatment outcome and with less resources and a significant reduced cost in selected cases compared with autogenous bone grafts from the iliac crest.
  •  
27.
  •  
28.
  • Dahlin, Christer, 1959, et al. (författare)
  • One-Year Results of a Clinical and Radiological Prospective Multicenter Study on NEOSS® Dental Implants.
  • 2013
  • Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899.
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: NEOSS® (Neoss Ltd., Harrogate, UK) dental implant system was introduced on the clinical arena in 2003. It is important that novel implant systems are systematically evaluated in a multicenter setting. Purpose: The aim of this study was to follow a large number of consecutively treated patients, with NEOSS dental implant system, both clinically and radiographically. The current report constitutes the 1-year data of a planned 5-year study. Materials and Methods: The study included a total of 177 patients treated with 590 NEOSS implants at 13 clinics in Sweden. The material was composed of 72 males and 105 females treated for single, partial, and total edentulism. Clinical, radiographic, and subjective evaluations were performed. Results: Out of 590 implants, 13 early failures have been reported, corresponding to a 1-year cumulative survival rate (CSR) of 97.8%. Evaluation of function and esthetics at the 1-year visit resulted in 100% success for function and 98% success for the esthetic outcome. The mean marginal bone loss was 0.6mm (SD 1.1) after 1year in clinical function. No adverse effects of the NEOSS dental implants were reported, and complications were few and similar to those reported for implant treatment in general. Conclusion: The CSR in the present study was 97.8%. No adverse effects of the NEOSS implants were reported, and complications during the study period were few and similar to those reported to for other well-documented implants system. Based on the present data, we conclude that NEOSS dental implant is a safe and predictable implant system. However, the high number of dropouts in the radiological evaluation must be considered when interpreting the data.
  •  
29.
  •  
30.
  • Dahlin, Christer, 1959, et al. (författare)
  • Osseointegration of implants.
  • 2011
  • Ingår i: Osteology guidelines for oral & maxillofacial regeneration: Preclinical models for translational research.. - Chicago, Il, USA : Nevins M, Giannobile W. Quintessence Publ Co..
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
  •  
31.
  •  
32.
  • Dahlin, Joakim S, et al. (författare)
  • Lineage- CD34hi CD117int/hi FcϵRI+ cells in human blood constitute a rare population of mast cell progenitors
  • 2016
  • Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:4, s. 383-391
  • Tidskriftsartikel (refereegranskat)abstract
    • Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage(-) CD34(hi) CD117(int/hi) FcϵRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated lineage(-) CD34(hi) CD117(int/hi) FcϵRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A mRNA transcripts were detected by quantitative RT-PCR. Altogether, we propose that the lineage(-) CD34(hi) CD117(int/hi) FcϵRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of lineage(-) CD34(hi) CD117(int/hi) FcϵRI(+) blood mast cell progenitors than asthmatics with normal lung function.
  •  
33.
  • Elgali, Ibrahim, et al. (författare)
  • Guided bone regeneration: materials and biological mechanisms revisited
  • 2017
  • Ingår i: European Journal of Oral Sciences. - : Wiley. - 0909-8836. ; 125:5, s. 315-337
  • Forskningsöversikt (refereegranskat)abstract
    • Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non-osteogenic tissues from interfering with bone regeneration is a key principle of GBR. Membrane materials possess a number of properties which are amenable to modification. A large number of membranes have been introduced for experimental and clinical verification. This prompts the need for an update on membrane properties and the biological outcomes, as well as a critical assessment of the biological mechanisms governing bone regeneration in defects covered by membranes. The relevant literature for this narrative review was assessed after a MEDLINE/PubMed database search. Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration. Nevertheless, the precise role of membrane porosities for the barrier function of GBR membranes still awaits elucidation. Novel experimental findings also suggest an active role of the membrane compartment per se in promoting the regenerative processes in the underlying defect during GBR, instead of being purely a passive barrier. The optimization of membrane materials by systematically addressing both the barrier and the bioactive properties is an important strategy in this field of research.
  •  
34.
  • Elgali, Ibrahim, et al. (författare)
  • Guided bone regeneration using resorbable membrane and different bone substitutes : Early histological and molecular events
  • 2016
  • Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1742-7061 .- 1878-7568. ; 29, s. 409-423
  • Tidskriftsartikel (refereegranskat)abstract
    • Bone insufficiency remains a major challenge for bone-anchored implants. The combination of guided bone regeneration (GBR) and bone augmentation is an established procedure to restore the bone. However, a proper understanding of the interactions between the bone substitute and GBR membrane materials and the bone-healing environment is lacking. This study aimed to investigate the early events of bone healing and the cellular activities in response to a combination of GBR membrane and different calcium phosphate (CaP) materials. Defects were created in the trabecular region of rat femurs, and filled with deproteinized bovine bone (DBB), hydroxyapatite (HA) or strontium-doped HA (SrHA) or left empty (sham). All the defects were covered with an extracellular matrix membrane. Defects were harvested after 12 h, 3 d and 6 d for histology/histomorphometry, immunohistochemistry and gene expression analyses. Histology revealed new bone, at 6 d, in all the defects. Larger amount of bone was observed in the SrHA-filled defect. This was in parallel with the reduced expression of osteoclastic genes (CR and CatK) and the osteoblast-osteoclast coupling gene (RANKL) in the SrHA defects. Immunohistochemistry indicated fewer osteoclasts in the SrHA defects. The observations of CD68 and periostin-expressing cells in the membrane per se indicated that the membrane may contribute to the healing process in the defect. It is concluded that the bone-promoting effects of Sr in vivo are mediated by a reduction in catabolic and osteoblast-osteoclast coupling processes. The combination of a bioactive membrane and CaP bone substitute material doped with Sr may produce early synergistic effects during GBR. Statement of significance The study provides novel molecular, cellular and structural evidence on the promotion of early bone regeneration in response to synthetic strontium-containing hydroxyapatite (SrHA) substitute, in combination with a resorbable, guided bone regeneration (GBR) membrane. The prevailing view, based mainly upon in vitro data, is that the beneficial effects of Sr are exerted by the stimulation of bone-forming cells (osteoblasts) and the inhibition of bone-resorbing cells (osteoclasts). In contrast, the present study demonstrates that the local effect of Sr in vivo is predominantly via the inhibition of osteoclast number and activity and the reduction of osteoblast-osteoclast coupling. This experimental data will form the basis for clinical studies, using this material as an interesting bone substitute for guided bone regeneration.
  •  
35.
  • Ferreria Kunrath, Marcel, 1988, et al. (författare)
  • Bench-to-bedside: Feasibility of nano-engineered and drug-delivery biomaterials for bone-anchored implants and periodontal applications
  • 2023
  • Ingår i: Materials Today Bio. - : Elsevier BV. - 2590-0064. ; 18
  • Tidskriftsartikel (refereegranskat)abstract
    • Nanotechnology and drug-release biomaterials have been thoroughly explored in the last few years aiming to develop specialized clinical treatments. However, it is rare to find biomaterials associated with drug delivery properties in the current dental market for application in oral bone-and periodontal-related procedures. The gap between basic scientific evidence and translation to a commercial product remains wide. Several challenges have been reported regarding the clinical translation of biomaterials with drug-delivery systems (BDDS) and nano -features. Therefore, processes for BDDS development, application in preclinical models, drug delivery doses, sterilization processes, storage protocols and approval requirements were explored in this review, associated with tentative solutions for these issues. The diversity of techniques and compounds/molecules applied to develop BDDS demands a case-by-case approach to manufacturing and validating a commercial biomaterial. Promising outcomes such as accelerated tissue healing and higher antibacterial response have been shown through basic and preclinical studies using BDDS and nano-engineered biomaterials; however, the adequate process for sterilization, storage, cost-effectiveness and possible cytotoxic effects remains unclear for multifunctional biomaterials incor-porated with different chemical compounds; then BDDSs are rarely translated into products. The future benefits of BDDS and nano-engineered biomaterials have been reported suggesting personalized clinical treatment and a promising reduction in the use of systemic antibiotics. Finally, the launch of these specialized biomaterials with solid data and controlled traceability onto the market will generate strong specificity for healthcare treatments.
  •  
36.
  • Ferreria Kunrath, Marcel, 1988, et al. (författare)
  • Does saliva contamination interfere or stimulate regenerative processes applying current biomaterials on oral surgical sites?
  • 2023
  • Ingår i: British Dental Journal. - : Springer Science and Business Media LLC. - 0007-0610 .- 1476-5373. ; 234:5, s. 305-307
  • Tidskriftsartikel (refereegranskat)abstract
    • Innovative dental biomaterials have been developed in order to stimulate higher biocompatibility and faster healing times using responsive surfaces for regenerative procedures. However, saliva is one of the fluids to interact with these biomaterials in the first instance. Studies have revealed significant negative effects on the biomaterials' properties, biocompatibility and bacterial colonisation after saliva contact. Nevertheless, the current literature is unclear about the profound effects of saliva on regenerative procedures. The scientific community urges further detailed studies associating innovative biomaterials/saliva/microbiology/immunology in order to clarify clinical outcomes. This paper discusses and provides information about the challenges of research using human saliva, the lack of standardisation in protocols applying saliva, and tentative applications of saliva proteins associated with innovative dental biomaterials.
  •  
37.
  • Ferreria Kunrath, Marcel, 1988, et al. (författare)
  • Implant surface modifications and their impact on osseointegration and peri-implant diseases through epigenetic changes: A scoping review.
  • 2024
  • Ingår i: Journal of periodontal research. - 1600-0765.
  • Tidskriftsartikel (refereegranskat)abstract
    • Dental implant surfaces and their unique properties can interact with the surrounding oral tissues through epigenetic cues. The present scoping review provides current perspectives on surface modifications of dental implants, their impact on the osseointegration process, and the interaction between implant surface properties and epigenetics, also in peri-implant diseases. Findings of this review demonstrate the impact of innovative surface treatments on the epigenetic mechanisms of cells, showing promising results in the early stages of osseointegration. Dental implant surfaces with properties of hydrophilicity, nanotexturization, multifunctional coatings, and incorporated drug-release systems have demonstrated favorable outcomes for early bone adhesion, increased antibacterial features, and improved osseointegration. The interaction between modified surface morphologies, different chemical surface energies, and/or release of molecules within the oral tissues has been shown to influence epigenetic mechanisms of the surrounding tissues caused by a physical-chemical interaction. Epigenetic changes around dental implants in the state of health and disease are different. In conclusion, emerging approaches in surface modifications for dental implants functionalized with epigenetics have great potential with a significant impact on modulating bone healing during osseointegration.
  •  
38.
  • Ferreria Kunrath, Marcel, 1988, et al. (författare)
  • Superhydrophilic Nanotextured Surfaces for Dental Implants: Influence of Early Saliva Contamination and Wet Storage
  • 2022
  • Ingår i: Nanomaterials. - : MDPI AG. - 2079-4991. ; 12:15
  • Tidskriftsartikel (refereegranskat)abstract
    • Hydrophilic and nanotextured surfaces for dental implants have been reported as relevant properties for early osseointegration. However, these surface characteristics are quite sensitive to oral interactions. Therefore, this pilot study aimed to investigate the superficial alterations caused on hydrophilic nanotubular surfaces after early human saliva interaction. Titanium disks were treated using an anodization protocol followed by reactive plasma application in order to achieve nanotopography and hydrophilicity, additionally; surfaces were stored in normal atmospheric oxygen or wet conditioning. Following, samples were interacted with saliva for 10 min and analyzed regarding physical-chemical properties and cellular viability. Saliva interaction did not show any significant influence on morphological characteristics, roughness measurements and chemical composition; however, hydrophilicity was statistically altered compromising this feature when the samples were stored in common air. Cellular viability tested with pre-osteoblasts cell line (MC3T3-E1) reduced significantly at 48 h on the samples without wet storage after saliva contamination. The applied wet-storage methodology appears to be effective in maintaining properties such as hydrophilicity during saliva interaction. In conclusion, saliva contamination might impair important properties of hydrophilic nanotubular surfaces when not stored in wet conditions, suggesting the need of saliva-controlled sites for oral application of hydrophilic surfaces and/or the use of modified-package methods associated with their wet storage.
  •  
39.
  • Ferreria Kunrath, Marcel, 1988, et al. (författare)
  • The Impact of Early Saliva Interaction on Dental Implants and Biomaterials for Oral Regeneration: An Overview
  • 2022
  • Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1422-0067. ; 23:4
  • Tidskriftsartikel (refereegranskat)abstract
    • The presence of saliva in the oral environment is relevant for several essential health processes. However, the noncontrolled early saliva interaction with biomaterials manufactured for oral rehabilitation may generate alterations in the superficial properties causing negative biological outcomes. Therefore, the present review aimed to provide a compilation of all possible physical-chemical-biological changes caused by the early saliva interaction in dental implants and materials for oral regeneration. Dental implants, bone substitutes and membranes in dentistry possess different properties focused on improving the healing process when in contact with oral tissues. The early saliva interaction was shown to impair some positive features present in biomaterials related to quick cellular adhesion and proliferation, such as surface hydrophilicity, cellular viability and antibacterial properties. Moreover, biomaterials that interacted with contaminated saliva containing specific bacteria demonstrated favorable conditions for increased bacterial metabolism. Additionally, the quantity of investigations associating biomaterials with early saliva interaction is still scarce in the current literature and requires clarification to prevent clinical failures. Therefore, clinically, controlling saliva exposure to sites involving the application of biomaterials must be prioritized in order to reduce impairment in important biomaterial properties developed for rapid healing.
  •  
40.
  • Friberg, Bertil, 1950, et al. (författare)
  • One-year results of a prospective multicenter study on Brånemark System implants with a TiUnite surface.
  • 2005
  • Ingår i: Clinical implant dentistry and related research. - 1523-0899. ; 7 Suppl 1
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: A moderately rough surface implant (TiUnite, Nobel Biocare AB, Göteborg, Sweden) was introduced in 2000. Laboratory studies and some clinical studies have demonstrated excellent bone response in the early healing phase. PURPOSE: The aim of this prospective multicenter study was to follow a large number of consecutively treated patients using Brånemark System implants with the TiUnite surface. The current report constitutes the 1-year data of a planned 3-year study. MATERIALS AND METHODS: Originally, the study comprised 43 surgeons from 22 centers in Sweden, Norway, and Finland. Five centers were excluded from the study because of poor compliance. Thus, 187 patients treated with 478 TiUnite implants were followed during 1 year of function. The majority of implants were inserted in maxillae (357 implants), and 78 of the implant sites were assigned the quality 4 figure. Radiographic evaluations were performed. RESULTS: Five implants were lost up to and including the 1-year follow-up, revealing implant cumulative survival rates of 98.6% and 100% for maxillae and mandibles, respectively. Three implants failed in quality 4 bone (3.8%). The mean marginal bone resorption at the end of the study period was 1.4 mm. The number of withdrawals of patients during the first year was high (19.3%). CONCLUSION: The present investigation showed a high implant cumulative survival rate of 98.9%. Values of marginal bone resorption were within normal ranges. No adverse effects of the TiUnite surface were reported, and complications during the study period were few and similar to those reported for the turned implant surface. However, the high number of excluded patients and the relatively high number of withdrawals must be observed and considered when interpreting data.
  •  
41.
  • Gustavii, Nils, et al. (författare)
  • Postoperative morbidity in traditional versus coblation tonsillectomy.
  • 2010
  • Ingår i: The Annals of otology, rhinology, and laryngology. - 0003-4894. ; 119:11, s. 755-760
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: The aim of this study was to compare levels of postoperative pain after traditional (cold steel with bipolar cautery) and Coblation tonsillectomies. METHODS: Patients with recurrent or chronic tonsillitis, including tonsillar hyperplasia, were randomized to undergo tonsillectomies using either a traditional cutting technique or the Coblation technique. Patients and staff on the relevant wards were blinded regarding patient allocation. Pain, odynophagia, and activity limitations were recorded on a visual analog scale. Analgesics were self-administered, and daily analgesic consumption by patients was reported. All complications were also registered. RESULTS: Fifty-seven patients (between 6 and 57 years of age) completed the study. No significant difference was found between the two techniques with regard to reported pain, odynophagia, activity limitations, or use of analgesics. A slight tendency toward decreased pain and decreased use of analgesics in the Coblation group reached statistical significance only when the adult patients were analyzed separately. Two cases of hospital readmission occurred because of postoperative bleeding following Coblation tonsillectomies. CONCLUSIONS: Overall,the two methods are equivalent in terms of postoperative pain,including the use of analgesics. The risk of postoperative bleeding after the Coblation method requires further evaluation with specifically designed studies.
  •  
42.
  • Hossein, Kashani, et al. (författare)
  • Influence of different prophylactic antibiotic regimens on implant survival rate: A retrospective clinical study
  • 2005
  • Ingår i: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH. - : Wiley. - 1523-0899 .- 1708-8208. ; 7:1, s. 32-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The routine use of antibiotics in oral implant treatment seems to be widespread. The pre- or postoperative use of antibiotics in conjunction with implant surgery and its correlation with failure and success rates are poorly documented in the literature. The debate regarding overprescription of antibiotics raises the need for a critical evaluation of proper antibiotic coverage in association with implant treatment. Purpose: The purpose of this study was to compare the implant survival rate following a 1-day single-dose preoperative antibiotic regimen with that following a 1-week postoperative antibiotic protocol. Materials and Methods: The study included 868 consecutively treated patients. A total of 3,021 implants were placed. The population was split into two categories, either receiving a 1-day single-dose administration only, or a 1-week postoperative administration of antibiotics. Healing was evaluated at second-stage surgery (6 months for the upper jaw, 3 months for the lower jaw). Failure was defined as removal of implants because of non-osseointegration. Statistical analyses were performed with analysis of variance and the Scheffe test, with a significance level of 5% for comparison of data. Results: No significant differences with regard to complications and implant survival were found in the study. Conclusion: Based on the present data, a more restrictive regimen consisting of a 1-day dose of prophylactic antibiotic in conjunction with routine implant procedures is recommended.
  •  
43.
  • Hossein, Kashani, et al. (författare)
  • Sinus-lift by Use of Hemihydrate-Calcium Sulphate: A Prospective Clinical, Radiographical, Histological Study of Implant Integration in the Posterior Maxilla
  • 2017
  • Ingår i: EC Dental Science. ; 15:6, s. 240-249
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this study was to evaluate implant survival in reconstructed bone after the use of a synthetic bone substitute material (Calcium Sulphate). Clinical, radiological and histological parameters were studied in 25 patients. Unilateral and bilateral sinus augmentation was performed. An 80% + 20% mixed alpha hemihydrate Calcium Sulphate with autograph bone respectively was applied into the maxillary sinus. After six months, dental implants were installed. Prior to implant installation, all patients underwent a CT examination. In total 91 implants were inserted in all 25 subjects, 74 of these in augmented bone. Additionally, two micro-implants were installed bilaterally in 8 patients. After four months of healing, a third operation was performed to insert the healing abutments into the implants. Simultaneously, the micro-implants were retrieved for histological analysis. Implant stability was assessed through resonance frequency analysis at installation and at abutment connection. The pattern of bone formation in the experimental sites was investigated using histomorphometric measurements. Implant survival rate was 96,8% at abutment connection. The mean ISQ value at implant placement was 65.8 and at abutment connection 66,5. The mean bone to implant contact was 27,0%.
  •  
44.
  • Johansson, Lars-Åke, 1950, et al. (författare)
  • Evaluation of bone regeneration after three different lateral sinus elevation procedures using micro-computed tomography of retrieved experimental implants and surrounding bone: a clinical, prospective, and randomized study.
  • 2013
  • Ingår i: The International journal of oral & maxillofacial implants. - : Quintessence Publishing. - 1942-4434 .- 0882-2786. ; 28:2, s. 579-86
  • Tidskriftsartikel (refereegranskat)abstract
    • To compare three different lateral sinus elevation procedures concerning new bone formation by using micro–computed tomography (micro-CT) of retrieved implants. Materials and Methods: Twenty-four consecutive partially dentate patients with a mean age of 64 years were included in the study and provided with 30 sinus elevation procedures. Three procedures for lateral sinus elevation were used: lateral sinus elevation with replacement of bone window and without bone graft (BW), lateral sinus elevation and covering osteotomy site with a collagen membrane and without bone graft (CM), and lateral sinus elevation with autogenous bone graft (ABG). Experimental implants were retrieved after 7 months of healing and analyzed by micro-CT. Results: One implant was found not to be integrated at the time of implant retrieval. This implant belonged to group CM and was excluded when calculating bone-to-implant contact (BIC) and intrasinus bone levels. The integrity of the lateral sinus bony wall was determined at the time of implant removal. In group ABG, all lateral sinus walls were ossified. In group BW, one lateral sinus wall was not completely ossified and in group CM, two lateral sinus walls. There were no statistical differences in %BIC between the groups: 93.5% (BW), 92.0% (CM) and 93.5% (ABG). Additionally, no statistical differences were found in apical intrasinus bone levels between the groups. When surfaces were compared within the same implant, a statistical difference was found between the apicobuccal distance and the apicolingual distance. The mean apicobuccal distances/apicolingual distances were 0.6 mm/1.2 mm for the BW group, 0.5 mm/0.8 mm for the CM group, and 0.6 mm/0.8 mm for the ABG group (P = .003). Conclusions: All three procedures were statistically equal when new bone formation was compared. Most of the examined implants’ apices were not covered with bone at the time of retrieval.
  •  
45.
  • Jung, R. E., et al. (författare)
  • Effect of peri-implant mucosal thickness on esthetic outcomes and the efficacy of soft tissue augmentation procedures: Consensus report of group 2 of the SEPA/DGI/OF workshop
  • 2022
  • Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 33, s. 100-108
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives The aim of this study was to comprehensively assess the literature in terms of the effect of peri-implant mucosal thickness on esthetic outcomes and the efficacy of soft tissue augmentation procedures to increase the mucosal thickness with autogenous grafts or soft tissue substitutes. Material and methods Two systematic reviews (SR) were performed prior to the consensus meeting to assess the following questions. Review 1, focused question: In systemically healthy patients with an implant-supported fixed prosthesis, what is the influence of thin as compared to thick peri-implant mucosa on esthetic outcomes? Review 2, focused question 1: In systemically healthy humans with at least one dental implant (immediate or staged implant), what is the efficacy of connective tissue graft (CTG), as compared to absence of a soft tissue grafting procedure, in terms of gain in peri-implant soft tissue thickness (STT) reported by randomized controlled clinical trials (RCTs) or controlled clinical trials (CCTs)? Review 2, focused question 2: In systemically healthy humans with at least one dental implant (immediate or staged implant), what is the efficacy of CTG, as compared to soft tissue substitutes, in terms of gain in peri-implant STT reported by RCTs or CCTs? The outcomes of the two SRs, the consensus statements, the clinical implications, and the research recommendations were discussed and subsequently approved at the consensus meeting during the group and plenary sessions. Conclusions There was a tendency of superior esthetic outcomes in the presence of a thick mucosa. The connective tissue graft remains the standard of care in terms of increasing mucosa thickness.
  •  
46.
  • Kroon, Ulla-Beth, et al. (författare)
  • Fast-track hysterectomy: a randomised, controlled study.
  • 2010
  • Ingår i: European journal of obstetrics, gynecology, and reproductive biology. - : Elsevier BV. - 1872-7654 .- 0301-2115. ; 151:2, s. 203-7
  • Tidskriftsartikel (refereegranskat)abstract
    • To investigate if intrathecally administered morphine combined with a low-dose mode of total intravenous anaesthesia (TIVA) accelerates recovery after abdominal surgery as compared, to patient-controlled analgesia (PCA) combined with anaesthesia, based on volatile anaesthetics.
  •  
47.
  • Linde, Anders, 1944, et al. (författare)
  • Creation of new bone by an osteopromotive membrane technique: An experimental study in rats
  • 1993
  • Ingår i: J Oral Maxillofac Surg. ; 51, s. 892-897
  • Tidskriftsartikel (refereegranskat)abstract
    • Domes, 5 and 8 mm in diameter, were made of expanded polytetrafluorethylene membrane with different degrees of stiffness and internodal distance. The domes were placed on denuded calvarial bones of rats and covered by the skin and periosteal flaps. Histologic evaluation 9 to 16 weeks after surgery showed the formation of various amounts of new bone on the calvarial bone surface inside the domes. The amount of bone neogenesis was dependent on membrane qualities, such as stiffness and porosity, and the length of the healing period. In the most successful experiments, about 80% of the dome volume was filled with newly formed bone, whereas in other experiments considerable amounts of connective tissue were present. Using bioabsorbable membrane domes proved less successful in that they did not maintain their shape and thus did not provide space for bone formation. This study showed that it is possible to obtain bone neogenesis by an osteopromotive membrane technique. This possibility may eventually be of great significance for reconstructive surgery.
  •  
48.
  • Miyahara, Takayuki, et al. (författare)
  • A novel dual material mouthguard for patients with dental implants.
  • 2013
  • Ingår i: Dental traumatology : official publication of International Association for Dental Traumatology. - : Wiley. - 1600-9657 .- 1600-4469. ; 29:4, s. 303-306
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: Dental implant-supported reconstructions demonstrate significantly less physiological flexibility for loading and traumatic forces compared with a normal dentition because of their rigid integration with the adjacent bone. Ethylene vinyl acetate (EVA) material has become widely accepted as a mouthguard material; however, many studies indicate the necessity of improving the impact absorption ability by considering the design and developing new materials. The aim of this study was to compare the shock-absorbing ability of a novel dual component material comprising EVA and porous rubber with that of EVA alone. MATERIALS AND METHODS: Three groups of samples were tested: Group 1=EVA (thickness, 4mm), Group 2=type 1 material (2-mm thick porous rubber sheet sandwiched between two sheets of 1-mm thick EVA sheets), and Group 3=type 2 material (1-mm thick porous rubber sheet sandwiched between EVA sheets with 1 and 2-mm thickness, respectively). Shock absorption was determined by means of a hammer impact testing device equipped with strain gauge, accelerator, and load cell. RESULTS: The value of shock-absorbing ability of group 2 (40.6±12.5%) was significantly higher than those of group 1 (15.6±2.1%) and group 3 (21.2±9.2%). The material with thicker rubber sheet showed significantly higher shock-absorbing ability compared with that of the material with thinner rubber sheet. CONCLUSIONS: The novel dual material was superior to conventional EVA material in shock-absorbing ability depending on the thickness of porous rubber, and it may be potentially effective as mouthguard material, in particular, for patients wearing implant-supported constructions.
  •  
49.
  • Mokhtari, Reza A., 1976, et al. (författare)
  • A randomized, multicenter, double-blinded parallel study to evaluate the safety and performance of zoledronate-coated versus uncoated dental implants in partially edentulous patients
  • 2024
  • Ingår i: Clinical Implant Dentistry and Related Research. - 1523-0899. ; 26:1, s. 78-87
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectiveTo evaluate patient safety, implants survival and implant stability of the bisphosphonate (zoledronate) as a coating on dental implants in patients requiring oral rehabilitation in the posterior maxilla.Materials and MethodsIn this multicenter, double-blind, randomized controlled study, 62 patients were randomized to receive either zoledronate-coated or uncoated control implants in the premolar or molar area of the maxilla, using a one stage-protocol. Due to dropouts and exclusion 49 patients completed the study. The implants were examined by resonance frequency analysis (RFA) using an implant stability quotient (ISQ) scale at the time of insertion, and at 8 weeks, and after 12 weeks prior to prosthetic restoration. Radiographs were taken prior to surgery, directly after insertion, and during the follow-up at 12 weeks, 6 months, and 1 year to analyze changes in marginal bone levels (MBL). Finally, all complications and adverse effects (AE) were observed and recorded.ResultsOut of 62 included patients, 49 patients completed the study. No AE were reported by patients receiving zoledronate-coated implants. There was no statistically significant difference between the zoledronate-coated or uncoated implant groups when comparing ISQ levels at insertion and after 12 weeks of healing, the mean of the ISQ values demonstrated a change of 4.64 (95% confidence interval: 15.46; 5.79, p = 0.43) between the two groups. At 8- and 12-weeks, ISQ values remained stable (range 62-70). Radiographic analysis showed no statistically significant difference in MBL between the two implant groups after 1 year of loading neither at the mesial side (p = 0.99) or the distal side (p = 0.97). MBL for coated implants were 0.57 mm at the mesial side and 0.46 mm at the distal side. For the uncoated implants, MBL was 0.48 mm at the mesial side and 0.47 mm at the distal side.ConclusionThe zoledronate-coated dental implants are safe to use in a one-stage surgery protocol in patients requiring oral rehabilitation in the posterior maxilla, after 1 year of loading. There were no statically significant changes in implant stability and marginal bone levels measured by intraoral radiographs in comparison to uncoated control implants.
  •  
50.
  • Munck-Ulfsfält, Ulla, et al. (författare)
  • Corporate ergonomics programme at Volvo Car Corporation
  • 2003
  • Ingår i: Applied Ergonomics. ; 34, s. 17-22
  • Tidskriftsartikel (refereegranskat)abstract
    • One of Volvo Car Corporation´s core values is Environmental Care". Volvo Cars has a tradition of attention to the work environment and has over the years developed a working environment management system, an organizational strategy for the participation of everyone, a working environment policy, standards/specifications and methods for efficient practical performance. The Production ergonomics Project is an example of this. In order to achieve results in ergonomics one has to work comprehensively, which means working with the product, the process, the workplace, the individuals and the work organization. The key to success is to train all categories concerned in load ergonomics and to perform methodical ergonomic work through the whole chain from design to production.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-50 av 74
Typ av publikation
tidskriftsartikel (68)
forskningsöversikt (3)
bokkapitel (2)
konferensbidrag (1)
Typ av innehåll
refereegranskat (71)
övrigt vetenskapligt/konstnärligt (3)
Författare/redaktör
Dahlin, Christer, 19 ... (71)
Omar, Omar (8)
Thomsen, Peter, 1953 (5)
Kashani, Hossein (5)
Sennerby, Lars, 1960 (5)
Johansson, Carina B. ... (5)
visa fler...
Andersson, Lars (4)
Trobos, Margarita, 1 ... (4)
Janson, Christer (3)
Hallgren, Jenny (3)
Larsson, Lena, 1969 (3)
Al-Asfour, Adel (3)
Farzad, Payam, 1973 (3)
Isaksson, Sten (2)
Tengvall, Pentti (2)
Malinovschi, Andrei, ... (2)
Lekholm, Ulf, 1944 (2)
Donos, N (2)
Becker, K. (1)
Galli, Silvia (1)
Linde, A (1)
Bove, Mogens, 1949 (1)
Thuvander, Mattias, ... (1)
Wennerberg, Ann, 195 ... (1)
Wälivaara, Dan-Åke (1)
Olsson, M. (1)
Hallman, M (1)
Helenius, Gisela, 19 ... (1)
Cardemil, Carina (1)
Afshari, Maryam K. (1)
Stavropoulos, Andrea ... (1)
Jemt, Torsten, 1950 (1)
Sanchez, N. (1)
Hultcrantz, M (1)
Fransson, M. (1)
Becker, W (1)
Correia, A. (1)
Al-Musawi, Ala (1)
Joseph, Bobby (1)
Malinovschi, Andrei (1)
Lundgren, Ted, 1959 (1)
Sandberg, Eva (1)
Nannmark, Ulf, 1958 (1)
Albrektsson, Tomas, ... (1)
Albrektsson, Tomas (1)
Wennerberg, Ann (1)
Reinedahl, David (1)
Trindade, Ricardo (1)
Buser, D. (1)
Friberg, Bertil, 195 ... (1)
visa färre...
Lärosäte
Göteborgs universitet (70)
Uppsala universitet (9)
Malmö universitet (4)
Karolinska Institutet (4)
Örebro universitet (3)
Chalmers tekniska högskola (3)
visa fler...
Umeå universitet (1)
Linköpings universitet (1)
visa färre...
Språk
Engelska (74)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (72)
Naturvetenskap (2)
Teknik (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy