| 1. |
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| 2. |
- Bignert, Anders, et al.
(författare)
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Comments Concerning the National Swedish Contaminant Monitoring Programme in Marine Biota, 2015
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The environmental toxicants examined in this report can be classified into five groups – heavy metals, chlorinated compounds, brominated flame retardants, polyaromatic hydrocarbons and perfluorinated compounds. Each of these contaminants have been examined from various sites for up to six different fish species, in blue mussels, and in guillemot eggs, for varying lengths of time. The following summary examines overall trends, spatial and temporal, for the five groups.Condition and Fat ContentCondition and fat content in different species tended to follow the same pattern at the same sites, with a few exceptions. Most of the fish species generally displayed a decreasing trend in both condition and fat content at most sites examined. Exceptions to this were increases in condition factor seen in cod liver at Fladen, perch muscle at Kvädöfjärden, and for herring at Ängskärsklubb in spring. Also, an increase in fat content was seen during the most recent ten years for herring at Ängskärsklubb in spring. There were also some sites where no log linear trends were seen.Heavy MetalsDue to a change in methods for metal analysis (not mercury) in 2004, values between 2003 and 2007 should be interpreted with care. From 2009 metals are analyzed at ACES, Stockholm University.Generally, higher mercury concentrations are found in the Bothnian Bay, but also from one station in the Northern parts of Baltic Proper, compared to other parts of the Swedish coastline. The time series show varying concentrations over the study period. The longer time series in guillemot egg and spring-caught herring from the southern Bothnian Sea and southern Baltic Proper show significant decreases of mercury. On the other hand, increasing concentrations are seen in e.g., cod muscle, but the concentrations are fairly low compared to measured concentrations in perch from fresh water and coastal sites. In most cases, the mercury concentrations are above the EQSbiota of 20 ng/g wet weight.Lead is generally decreasing over the study period (in time series of sufficient length), supposedly due to the elimination of lead in gasoline. The highest concentrations are seen in the southern part of the Baltic Sea. Elevated lead concentrations between 2003 and 2007 (e.g. Harufjärden) should be viewed with caution (see above regarding change in analysis methods). Lead concentrations are below the suggested target level at all stations.Cadmium concentrations show varying non-linear trends over the monitored period. It is worth noting that despite several measures taken to reduce discharges of cadmium, generally the most recent concentrations are similar to concentrations measured 30 yearsago in the longer time series. Cadmium concentrations in herring and perch are all below the suggested target level of 160 μg/kg wet weight.The reported nickel concentrations show no consistent decreasing trends. Some series begin with two elevated values that exert a strong leverage effect on the regression line and may give a false impression of decreasing trends. Chromium generally shows decreasing concentrations, possibly explained by a shift in analytical method. The essential trace metals, copper and zinc, show no consistent trends during the monitored period.Generally higher concentrations of arsenic and silver are found along the west coast compared to other parts of the Sweadish coast line. However for silver a few stations in the Bothnian Sea and Bothnian Bay show comparable concentrations to the west coast stations.Chlorinated CompoundsGenerally, a decreasing concentrations were observed for all compounds (DDT’s, PCB’s, HCH’s, HCB) in all species examined, with a few exceptions, such as no change in TCDD-equivalents being seen in herring muscle (except at Änskärsklubb where very high concentrations at the beginning of the sampling period were seen and also at the west coast station Fladen). The longer time-series in guillemot also show a marked decrease in TCDD-equivalents from the start in the late 1960s until about 1985 from where no change occurred for many years, however, during the most recent ten years a decrease in the concentration is seen. Concentrations of DDE and CB-118 are for some species and sites still above their respective target levels.The chlorinated compounds generally show higher concentrations in the Bothnian Sea and/or Baltic Proper when compared to the Bothnian Bay and the Swedish west coast.Brominated Flame RetardantsElevated levels of HBCDD are seen in sites from the Baltic Proper, while the investigated PBDEs show higher concentrations in the Bothnian Bay. In addition, lower concentrations of all investigated PBDEs and HBCDD are seen on the Swedish west coast compared to the east coast. Temporally, significant increases in BDE-47, -99 and -100 have been seen in guillemot eggs since the late 1960s until the early 1990s, where concentrations then began to show decreases. Also, the concentration of HBCDD in guillemot eggs shows a decrease during the most recent ten years. For fish and blue mussels, BDE-47, -99, and -153 decreased at some sites and showed no trend at other sites. The concentration of HBCDD in fish and blue mussels showed inconsistent trends. The concentration of HBCDD is below the EQSbiota of 167 μg/kg wet weight for all fish species from all areas, while the concentration of BDE-47 alone is above the EQSbiota for sumPBDE of 0.0085 ng/g wet weight.PAHsOnly blue mussels have been examined for spatial differences in PAH concentrations. Concentration of ΣPAH was found to be higher from Kvädöfjärden in the Baltic Proper compared to stations at the West coast, but individual PAHs showed varying spatial patterns. Over time, acenaphthalene was rarely found above the detection limit. Significant decreasing trends were observed for ΣPAH, chrysene, fluoranthene and pyrene at Fjällbacka; for naphthalene at Kvädöfjärden; and for pyrene at Fladen.All time series where concentrations of various PAHs were compared with the target value based on OSPAR Ecological Assessment Criteria, or EC Environmental Quality Standards were below the target value.PFASsPFHxS and PFOS show a similar spatial pattern, but PFOS concentrations were approximately 25 times higher than PFHxS levels. The distribution of PFOS is quite homogenous along the Swedish coast but with somewhat higher concentrations in the Baltic Proper. PFOS concentrations in guillemot eggs are about 100-200 times higher than in herring liver. An overall increasing concentration of PFOS in guillemot eggs has been observed throughout the whole time period, however, during the most recent ten years, a change of direction is detected. The longer herring time series from Harufjärden, Landsort, and Utlängan show increasing concentrations for PFOS and most carboxylates. For FOSA, on the other hand, decreasing concentrations are seen during the most recent ten years.Organotin compoundsThe majority of the analysed tinorganic compounds showed concentrations below LOQ. However TBT and DPhT showed concentrations above LOQ at all stations with highest reported concentrations in fish from Örefjärden in the northern part of Bothnian Sea.
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| 3. |
- Danielsson, Jakob
(författare)
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Automatic Characterization and Mitigation of Shared-resource Contention in Multi-core Systems
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Multi-core computers are infamous for being hard to use in time-critical systems due to execution-time variations as an effect of shared resource contention. In this thesis, we study the problem of shared resource contention, which occurs when multiple applications executing on different cores do not have exclusive access to of a shared hardware resource. We investigate performance variations of parallel tasks in multi-core systems and present a method to pinpoint the source of the resource contention using hardware performance counters. We investigate mitigation methods for performance variations due to resource contention, including the Jailhouse hypervisor and the cache-partitioning tool PALLOC. We propose a benchmark strategy that quantifies the isolation gained from a specific isolation technique and exemplify this strategy using the Jailhouse hypervisor. We furthermore present and implement solutions for cache-partition allocation during application runtime. Our implementation aims to avoid over-provisioning of cache through pre-runtime estimations of an application's dependency towards the cache and continuous re-partitioning of the cache memory during application runtime.The primary goal of this thesis is to contribute to a process that automates some of the tedious manual testing needed to detect resource contention bottlenecks. The methods we present in this provide a holistic solution for automatic mitigating resource-contention in a multi-core system. First, we evaluate the risk for shared resource contention when several applications execute simultaneously. We then allocate partitions to mitigate resource contention for applications that risk severe performance degradations. We finally present methods that dynamically re-allocate partition space to meet the performance requirements of the running applications.
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| 4. |
- Danielsson, Jakob, et al.
(författare)
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Automatic Quality of Service Control in Multi-core Systems using Cache Partitioning
- 2021
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Konferensbidrag (refereegranskat)abstract
- In this paper, we present a last-level cache partitioning controller for multi-core systems. Our objective is to control the Quality of Service (QoS) of applications in multi-core systems by monitoring run-time performance and continuously re-sizing cache partition sizes according to the applications' needs. We discuss two different use-cases; one that promotes application fairness and another one that prioritizes applications according to the system engineers' desired execution behavior. We display the performance drawbacks of maintaining a fair schedule for all system tasks and its performance implications for system applications. We, therefore, implement a second control algorithm that enforces cache partition assignments according to user-defined priorities rather than system fairness. Our experiments reveal that it is possible, with non-instrusive (0.3-0.7\% CPU utilization) cache controlling measures, to increase performance according to setpoints and maintain the QoS for specific applications in an over-saturated system.
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| 5. |
- Danielsson, Jakob, et al.
(författare)
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LLM-shark -- A Tool for Automatic Resource-boundness Analysis and Cache Partitioning Setup
- 2021
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Ingår i: 45th IEEE Annual Computers, Software, and Applications Conference, COMPSAC 2021. - 9781665424639 ; , s. 49-58
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Konferensbidrag (refereegranskat)abstract
- We present LLM-shark, a tool for automatic hardware resource-boundness detection and cache-partitioning. Our tool has three primary objectives: First, it determines the hardware resource-boundness of a given application. Secondly, it estimates the initial cache partition size to ensure that the application performance is conserved and not affected by other processes competing for cache utilization. Thirdly, it continuously monitors that the application performance is maintained over time and, if necessary, change the cache partition size. We demonstrate LLM-shark's functionality through a series of tests using six different applications, including a set of feature detection algorithms and two synthetic applications. Our tests reveal that it is possible to determine an application's resource-boundness using a Pearson-correlation scheme implemented in LLM-shark. We propose a scheme to size cache partitions based on the correlation coefficient applications depending on their resource boundness.
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| 6. |
- Danielsson, Jakob, et al.
(författare)
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Measurement-based evaluation of data-parallelism for OpenCV feature-detection algorithms
- 2018
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Ingår i: Staying Smarter in a Smartening World COMPSAC'18. - 9781538626665 ; , s. 701-710
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Konferensbidrag (refereegranskat)abstract
- We investigate the effects on the execution time, shared cache usage and speed-up gains when using data-partitioned parallelism for the feature detection algorithms available in the OpenCV library. We use a data set of three different images which are scaled to six different sizes to exercise the different cache memories of our test architectures. Our measurements reveal that the algorithms using the default settings of OpenCV behave very differently when using data-partitioned parallelism. Our investigation shows that the executions of the algorithms SURF, Dense and MSER correlate to L3-cache usage and they are therefore not suitable for data-partitioned parallelism on multi-core CPUs. Other algorithms: BRISK, FAST, ORB, HARRIS, GFTT, SimpleBlob and SIFT, do not correlate to L3-cache in the same extent, and they are therefore more suitable for data-partitioned parallelism. Furthermore, the SIFT algorithm provides the most stable speed-up, resulting in an execution between 3 and 3.5 times faster than the original execution time for all image sizes. We also have evaluated the hardware resource usage by measuring the algorithm execution time simultaneously with the L3-cache usage. We have used our measurements to conclude which algorithms are suitable for parallelization on hardware with shared resources.
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| 7. |
- Danielsson, Jakob, et al.
(författare)
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Modelling Application Cache Behavior using Regression Models
- 2021
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Konferensbidrag (refereegranskat)abstract
- In this paper, we describe the creation of resource usage forecasts for applications with unknown execution characteristics, by evaluating different regression processes, including autoregressive, multivariate adaptive regression splines, exponential smoothing, etc. We utilize Performance Monitor Units (PMU) and generate hardware resource usage models for the L-2-cache and the L-3-cache using nine different regression processes. The measurement strategy and regression process methodology are general and applicable to any given hardware resource when performance counters are available. We use three benchmark applications: the SIFT feature detection algorithm, a standard matrix multiplication, and a version of Bubblesort. Our evaluation shows that Multi Adaptive Regressive Spline (MARS) models generate the best resource usage forecasts among the considered models, followed by Single Exponential Splines (SES) and Triple Exponential Splines (TES).
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| 8. |
- Danielsson, Jakob, et al.
(författare)
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Resource Depedency Analysis in Multi-Core Systems
- 2020
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Ingår i: Proceedings - 2020 IEEE 44th Annual Computers, Software, and Applications Conference, COMPSAC 2020. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728173030 ; , s. 87-94
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Konferensbidrag (refereegranskat)abstract
- In this paper, we evaluate different methods for statistical determination of application resource dependency in multi-core systems. We measure the performance counters of an application during run-time and create a system resource usage profile. We then use the resource profile to evaluate the application dependency on the specific resource. We discuss and evaluate two methods to process the data, including moving average filter and partitioning the data into smaller segments in order to interpret data for correlation calculations. Our aim with this study is to evaluate and create a generalizeable methods for automatic determination of resource dependencies. The final outcome of the methods used in this study is the answer to the question: 'To what resources is this application dependent on?'. The recommendation of this tool will be used in conjunction with our last-level cache partitioning controller (LLC-PC), to make decision if an application should receive last-level cache partition slices.
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| 9. |
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| 10. |
- Danielsson, Jakob, et al.
(författare)
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Testing Performance-Isolation in Multi-Core Systems
- 2019
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a methodology to be used for quantifying the level of performance isolation for a multi-core system. We have devised a test that can be applied to breaches of isolation in different computing resources that may be shared between different cores. We use this test to determine the level of isolation gained by using the Jailhouse hypervisor compared to a regular Linux system in terms of CPU isolation, cache isolation and memory bus isolation. Our measurements show that the Jailhouse hypervisor provides performance isolation of local computing resources such as CPU. We have also evaluated if any isolation could be gained for shared computing resources such as the system wide cache and the memory bus controller. Our tests show no measurable difference in partitioning between a regular Linux system and a Jailhouse partitioned system for shared resources. Using the Jailhouse hypervisor provides only a small noticeable overhead when executing multiple shared-resource intensive tasks on multiple cores, which implies that running Jailhouse in a memory saturated system will not be harmful. However, contention still exist in the memory bus and in the system-wide cache.
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| 11. |
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| 12. |
- Danielsson, Marcus, et al.
(författare)
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Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
- 2020
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 28:3, s. 349-357
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Tidskriftsartikel (refereegranskat)abstract
- Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is associated with increased risk for all-cause mortality, various forms of cancer and Alzheimer's disease, as well as other common human diseases. By tracking LOY frequencies in subjects from which blood samples have been serially collected up to five times during up to 22 years, we observed a pronounced intra-individual variation of changes in the frequency of LOY within individual men over time. We observed that in some individuals the frequency of LOY in blood clearly progressed over time and that in other men, the frequency was constant or showed other types of longitudinal development. The predominant method used for estimating LOY is calculation of the median Log R Ratio of probes located in the male specific part of chromosome Y (mLRRY) from intensity data generated by SNP-arrays, which is difficult to interpret due to its logarithmic and inversed scale. We present here a formula to transform mLRRY-values to percentage of LOY that is a more comprehensible unit. The formula was derived using measurements of LOY from matched samples analysed using SNP-array, whole genome sequencing and a new AMELX/AMELY-based assay for droplet digital PCR. The methods described could be applied for analyses of the vast amount of SNP-array data already generated in the scientific community, allowing further discoveries of LOY associated diseases and outcomes.
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| 13. |
- Danielsson, Marcus, 1985-
(författare)
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Mosaic loss of chromosome Y : methods for detection and consequences for affected leukocytes and men
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- It has been known for centuries that men live shorter lives than women, but until recently, the biological mechanisms driving this sex bias has been poorly understood. Mosaic loss of chromosome Y (mLOY) refers to chromosome Y aneuploidy, a male specific and the most common somatic mutation in human blood cells. Known risk factors include age, smoking and genetic predisposition. Men with mLOY carry a fraction of blood cells without the Y chromosome, due to its loss from hematopoietic progenitor cells during life. Hence, in a single cell LOY is a binary event causing the absence of almost 2% of the male haploid nuclear genome. When measured in bulk samples, it is present as a continuous mosaicism affecting a fraction of cells. A paper published in 1963 demonstrated that mLOY is frequent in cells of the hematopoietic system in aging men, but it was long viewed as a neutral event. In contrast, recent discoveries demonstrate that mLOY in blood is associated with various forms of cancer, autoimmune conditions, Alzheimer’s disease, cardiovascular events, diabetes as well as age-related macular degeneration. Studies support the hypothesis that mLOY in leukocytes may exacerbate disease processes in other organs. Thus, given the associations with several common diseases, mLOY in blood cells could help explain reduced male longevity.A main aim and a long term goal of the work presented in this thesis is the development of novel methods for improved mLOY detection. Focus here is exploration of analytes such as DNA, RNA and proteins, including studies of bulk samples as well as single cell approaches. Among the evaluated methods are SNP-arrays, ddPCR, WGS, RNA-seq and CITE-seq. Furthermore, a novel method called SPARC was developed for co-detection of the transcriptome and a panel of 92 proteins in single cells. Future methods with clinical utility for mLOY should, in addition to robust detection, be able to simultaneously discriminate mLOY in different types of immune cells. The latter builds on recent results showing cell type specificity with regard to disease associations. To meet these needs, single cell analyses using mLOY associated cell surface proteins have been pursued and proof-of-concept established. Implementation of mLOY screening in general populations has the potential to identify men with increased risk for various disease. It could be envisioned that further medical examination of men affected with mLOY would enable earlier diagnoses of ongoing disease processes as well as serving to guide targeted interventions.
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| 14. |
- Danielsson, Marcus, et al.
(författare)
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Reply to Veitia
- 2021
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Ingår i: European Journal of Human Genetics. - : Springer Nature. - 1018-4813 .- 1476-5438. ; 29:9, s. 1323-1324
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Danielsson, Pernilla, et al.
(författare)
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Importance of age for 3-year continuous behavioral obesity treatment success and dropout rate.
- 2012
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Ingår i: Obesity Facts. - 1662-4025 .- 1662-4033. ; 5:1, s. 34-44
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Tidskriftsartikel (refereegranskat)abstract
- AbstractObjective: To assess whether first year weight loss, age, and socioeconomic background correlate with the success rate of continuous long-term behavioral obesity treatment. Methods: In a 3-year longitudinal study, obese children (n = 684) were divided into three groups based on age at the start of treatment, age 6-9 years, 10-13 years, and 14-16 years. Results: The mean BMI standard deviation score (BMI-SDS) decline was age-dependent (p = 0.001), independently of adjustment for missing data: -1.8 BMI-SDS units in the youngest, -1.3 in the middle age group, and -0.5 in the oldest age group. SES and parental BMI status did not affect the results. 30% of the adolescents remained in treatment at year 3. There was only a weak correlation between BMI-SDS change after 1 and 3 years: r = 0.51 (p < 0.001). Among children with no BMI-SDS reduction during year 1 (n = 46), 40% had a clinically significantly reduced BMI-SDS after year 3. Conclusion: Behavioral treatment should be initiated at an early age to increase the chance for good results. Childhood obesity treatment should be continued for at least 3 years, regardless of the initial change in BMI-SDS. Copyright © 2012 S. Karger GmbH, Freiburg.
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| 19. |
- Danielsson, P, et al.
(författare)
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Importance of age for 3-year continuous behavioral obesity treatment success and dropout rate
- 2012
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Ingår i: Obesity facts. - : S. Karger AG. - 1662-4033 .- 1662-4025. ; 5:1, s. 34-44
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Tidskriftsartikel (refereegranskat)abstract
- <i>Objective:</i> To assess whether first year weight loss, age, and socioeconomic background correlate with the success rate of continuous long-term behavioral obesity treatment. <i>Methods: </i>In a 3-year longitudinal study, obese children (n = 684) were divided into three groups based on age at the start of treatment, age 6–9 years, 10–13 years, and 14–16 years. <i>Results:</i> The mean BMI standard deviation score (BMI-SDS) decline was age-dependent (p = 0.001), independently of adjustment for missing data: –1.8 BMI-SDS units in the youngest, –1.3 in the middle age group, and –0.5 in the oldest age group. SES and parental BMI status did not affect the results. 30% of the adolescents remained in treatment at year 3. There was only a weak correlation between BMI-SDS change after 1 and 3 years: r = 0.51 (p < 0.001). Among children with no BMI-SDS reduction during year 1 (n = 46), 40% had a clinically significantly reduced BMI-SDS after year 3. <i>Conclusion:</i> Behavioral treatment should be initiated at an early age to increase the chance for good results. Childhood obesity treatment should be continued for at least 3 years, regardless of the initial change in BMI-SDS.
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| 20. |
- Danielsson, Pernilla, et al.
(författare)
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Response of severely obese children and adolescents to behavioral treatment.
- 2012
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Ingår i: Archives of Pediatrics & Adolescent Medicine. - : American Medical Association (AMA). - 1072-4710 .- 1538-3628. ; 166:12, s. 1103-1108
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES:To investigate whether the degree of obesity predicts the efficacy of long-term behavioral treatment and to explore any interaction with age.DESIGN:A 3-year longitudinal observational study. Obese children were divided into 3 age groups (6-9, 10-13, and 14-16 years) and also into 2 groups (moderately obese, with a body mass index [BMI]-standard deviation [SD] score [or z score] of 1.6 to <3.5, and severely obese, with a BMI-SD score of ≥3.5).SETTING:National Childhood Obesity Center, Stockholm, Sweden.PARTICIPANTS:Children 6 to 16 years of age who started treatment between 1998 and 2006.INTERVENTION:Behavioral treatment of obesity.MAIN OUTCOME MEASURE:Change in BMI-SD score during 3 years of treatment; a reduction in BMI-SD score of 0.5 units or more was defined as clinically significant.RESULTS:A total of 643 children (49% female children) met the inclusion criteria. Among the youngest moderately obese children, 44% had a clinically significant reduction in BMI-SD score (mean reduction, -0.4 [95% CI, -0.55 to -0.32]). Treatment was less effective for the older moderately obese children. Twenty percent of children who were 10 to 13 years of age and 8% of children who were 14 to 16 years of age had a reduction in BMI-SD score of 0.5 units or more; 58% of the severely obese young children showed a clinically significant reduction in BMI-SD score (mean reduction, -0.7 [95% CI, -0.80 to -0.54]). The severely obese adolescents showed no change in mean BMI-SD score after 3 years, and 2% experienced clinically significant weight loss. Age was found to be a predictor of a reduction in BMI-SD score (odds ratio, 0.68 units per year [95% CI, 0.60-0.77 units per year]).CONCLUSIONS:Behavioral treatment was successful for severely obese children but had almost no effect on severely obese adolescents.
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| 21. |
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Dumanski, Jan P., et al.
(författare)
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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
- 2021
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 78:8, s. 4019-4033
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Tidskriftsartikel (refereegranskat)abstract
- Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation and is associated with aberrant clonal expansion of cells, yet it remains unclear whether this mosaicism exerts a direct physiological effect. We studied DNA and RNA from leukocytes in sorted- and single-cells in vivo and in vitro. DNA analyses of sorted cells showed that men diagnosed with Alzheimer’s disease was primarily affected with LOY in NK cells whereas prostate cancer patients more frequently displayed LOY in CD4 + T cells and granulocytes. Moreover, bulk and single-cell RNA sequencing in leukocytes allowed scoring of LOY from mRNA data and confirmed considerable variation in the rate of LOY across individuals and cell types. LOY-associated transcriptional effect (LATE) was observed in ~ 500 autosomal genes showing dysregulation in leukocytes with LOY. The fraction of LATE genes within specific cell types was substantially larger than the fraction of LATE genes shared between different subsets of leukocytes, suggesting that LOY might have pleiotropic effects. LATE genes are involved in immune functions but also encode proteins with roles in other diverse biological processes. Our findings highlight a surprisingly broad role for chromosome Y, challenging the view of it as a “genetic wasteland”, and support the hypothesis that altered immune function in leukocytes could be a mechanism linking LOY to increased risk for disease.
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| 26. |
- Ek, Caroline, et al.
(författare)
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Evaluation of different stable isotope methods to estimate trophic position of perch (Perca fluviatilis) in Swedish lakes
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Water Framework Directive (WFD) requires member states to implement a strategy to meet the environmental quality standards (EQS) set by the WFD for a number of priority substances. Since the EQSs listed in the WFD are derived to protect the most sensitive species in the ecosystem, often top predators or humans, it has been decided that for certain priority substances the quality standards should be compared to a monitoring species with a trophic position (TP) similar to the diet of the most sensitive species. To enable such adjustment require both knowledge about the monitoring species TP in the food web as well as the relationship between contaminant concentration and trophic position. In this study, we focus on finding a suitable method for TP estimates of perch in Swedish lakes by evaluating both traditional stable isotope analysis in bulk samples (BSIA) using different baseline matrices and the more recent development of compound-specific stable isotope analysis in amino acids (CSIA-AA). For this, three representative monitoring lakes were selected in which perch together with potential baseline matrices (bivalves, gastropods and sediment) were sampled. We applied triple-isotope analyses, d15N, d13C and d34S, of bulk material of all sampled matrices, and in addition d15N in perch using CSIA-AA. Results showed that TP estimates derived from CSIA-AA were significantly (p<0.001) lower compared to all the BSIA-derived methods and further that the BSIA-derived TP estimates using gastropods as a baseline were significantly higher (p<0.001) than all other TP estimates. Since no statistical differences could be detected between TP estimates based on bivalves, sediment or a ‘mixture’ baseline these were assumed to produce similar results and therefore all valid baseline matrices for TP estimates of perch in these three lakes. In the present study we also attempted to adjust mercury contaminant data to a specific TP of 3.5 according to the WFD. The adjustment resulted in significantly different concentration for one of the two tested lakes but did not influence the chemical status classification as all lakes were well above the threshold for mercury in freshwater lakes.
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| 27. |
- Ek, caroline, et al.
(författare)
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Utvärdering av stabila isotoper som metod för att uppskatta trofinivå i abborre (Perca fluviatilis) från Svenska sjöar
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Water Framework Directive (WFD) requires member states to implement a strategy to meet the environmental quality standards (EQS) set by the WFD for a number of priority substances. Since the EQSs listed in the WFD are derived to protect the most sensitive species in the ecosystem, often top predators or humans, it has been decided that for certain priority substances the quality standards should be compared to a monitoring species with a trophic position (TP) similar to the diet of the most sensitive species. To enable such adjustment require both knowledge about the monitoring species TP in the food web as well as the relationship between contaminant concentration and trophic position. In this study, we focus on finding a suitable method for TP estimates of perch in Swedish lakes by evaluating both traditional stable isotope analysis in bulk samples (BSIA) using different baseline matrices and the more recent development of compound-specific stable isotope analysis in amino acids (CSIA-AA). For this, three representative monitoring lakes were selected in which perch together with potential baseline matrices (bivalves, gastropods and sediment) were sampled. We applied triple-isotope analyses, δ15N, δ13C and δ34S, of bulk material of all sampled matrices, and in addition δ15N in perch using CSIA-AA. Results showed that TP estimates derived from CSIA-AA were significantly (p<0.001) lower compared to all the BSIA-derived methods and further that the BSIA-derived TP estimates using gastropods as a baseline were significantly higher (p<0.001) than all other TP estimates. Since no statistical differences could be detected between TP estimates based on bivalves, sediment or a ‘mixture’ baseline these were assumed to produce similar results and therefore all valid baseline matrices for TP estimates of perch in these three lakes. In the present study we also attempted to adjust mercury contaminant data to a specific TP of 3.5 according to the WFD. The adjustment resulted in significantly different concentration for one of the two tested lakes but did not influence the chemical status classification as all lakes were well above the threshold for mercury in freshwater lakes.
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| 28. |
- Forsberg, Lars A., 1974-, et al.
(författare)
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Mosaic loss of chromosome Y in leukocytes matters
- 2019
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:1, s. 4-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 29. |
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| 34. |
- Imtiaz, Shamoona, et al.
(författare)
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Towards Automatic Application Fingerprinting Using Performance Monitoring Counters
- 2021
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Ingår i: ACM International Conference Proceeding Series. - New York, NY, USA : Association for Computing Machinery. - 9781450390576
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Konferensbidrag (refereegranskat)abstract
- In this paper, we discuss a method for application fingerprinting using conventional hardware and software performance counters. Modern applications are complex and often utilizes a broad spectra of the available hardware resources, where multiple performance counters can be of significant interest. The number of performance counters that can be captured simultaneously is, however, small due to hardware limitations in most modern computers. We propose to mitigate the hardware limitations using an intelligent mechanism that pinpoints the most relevant performance counters for an application's performance. In our proposal, we utilize the Pearson correlation coefficient to rank the most relevant PMU events and filter out events of less relevance to an application's execution. Our ultimate goal is to establish a comparable application fingerprint model using performance counters, that we can use to classify applications. The classification procedure can then be used to determine the type of application's fingerprint, such as malicious software.
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| 35. |
- Jacobsson, Josefin A., et al.
(författare)
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Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes.
- 2008
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 368:3, s. 476-482
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have shown that SNPs in the FTO gene predispose to childhood and adult obesity. In this study, we examined the association between variants in FTO and KIAA1005, a gene that maps closely to FTO, and obesity, as well as obesity related traits among 450 well characterised severely obese children and 512 normal weight controls. FTO showed significant association with several obesity related traits while SNPs in KIAA1005 did not. When stratified by gender, the FTO variant rs9939609 showed association with obesity and BMI among girls (P=0.006 and 0.004, respectively) but not among boys. Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose. This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children.
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| 36. |
- Jacobsson, J. A., et al.
(författare)
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Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.
- 2008
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 32:11, s. 1730-1735
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND The global prevalence of obesity and overweight is increasing rapidly among adults as well as among children and adolescents. Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity. We sequenced regions of the FTO gene to identify novel variants that are associated with obesity and related metabolic traits. RESULTS We screened exons 3 and 4 including exon-intron boundaries in FTO in 48 obese children and adolescents and identified three novel single nucleotide polymorphism in the fourth intronic region, (c.896+37A>G, c.896+117C>G and c.896+223A>G). We further genotyped c.896+223A>G in 962 subjects, 450 well-characterized obese children and adolescents and 512 adolescents with normal weight. Evidence for differences in genotype frequencies were not detected for the c.896+223A>G variant between extremely obese children and adolescents and normal weight adolescents (P=0.406, OR=1.154 (0.768-1.736)). Obese subjects with the GG genotype, however, had 30% increased fasting serum insulin levels (P=0.017) and increased degree of insulin resistance (P=0.025). There were in addition no differences in body mass index (BMI) or BMI standard deviation score (SDS) levels among the obese subjects according to genotype and the associations with insulin levels and insulin resistance remained significant when adjusting for BMI SDS. CONCLUSION These findings suggest that this novel variant in FTO is affecting metabolic phenotypes such as insulin resistance, which are not mediated through differences in BMI levels.
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| 37. |
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| 38. |
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| 39. |
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| 40. |
- Johansson, Lovisa, et al.
(författare)
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Genetic variance in the adiponutrin gene family and childhood obesity.
- 2009
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 4:4
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. METHODS/RESULTS: Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p>0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: beta = -0.053, p = 0.016, and rs2072907: beta = -0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. CONCLUSIONS: Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.
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| 41. |
- Johansson, Lovisa, et al.
(författare)
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Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity.
- 2009
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Ingår i: International Journal of Pediatric Obesity. - : Informa UK Limited. - 1747-7174 .- 1747-7166. ; 4, s. 119-125
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Tidskriftsartikel (refereegranskat)abstract
- Aim. The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. Methods. Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype. Results. We found no association for PPARG or ADIPOQ polymorphisms with Body Mass Index (BMI), High Density Lipoprotein (HDL)-cholesterol, triglycerides or Insulin Resistance estimated by Homeostasis Model of Assessment (HOMA-IR). Wild type carriers of PPARG Pro12Ala (p<0.05), homozygous carriers of the variant allele of ADIPOQ G276T (p<0.001) and epsilon4 carriers of APOE (p<0.001) had higher total and low density lipoprotein (LDL)-cholesterol levels adjusted for age, gender, BMI and insulin sensitivity. A PPARG/ADIPOQ risk genotype combination was identified by analysis of covariance (ANCOVA) comparing all existing combinations. Carriers of PPARG Pro/Pro and ADIPOQ 276 T/T had higher total (5.0 [4.1-5.8] vs. 4.1 [3.6-4.6]mmol/l) and LDL-cholesterol levels (3.7 [2.9-4.5] vs. 3.0 [2.5-3.5]mmol/l) compared with carriers of other combinations (p<0.001). Importantly, the PPARG and ADIPOQ associations were unaffected when adjusting for APOE genotype. Conclusions. Genetic variants in candidate genes for insulin resistance are associated with cholesterol levels in obese children and adolescents, and may offer additional information in the risk assessment of obese children.
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| 42. |
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| 43. |
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| 44. |
- Liegnell, Rasmus, et al.
(författare)
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Elevated plasma lactate levels via exogenous lactate infusion do not alter resistance exercise-induced signaling or protein synthesis in human skeletal muscle.
- 2020
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Ingår i: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 319, s. E792-E804
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Tidskriftsartikel (refereegranskat)abstract
- Lactate has been implicated as a potential signaling molecule. In myotubes, lactate incubation increases mTORC1- and ERK-signaling and induces hypertrophy, indicating that lactate could be a mediator of muscle adaptations to resistance exercise. However, the potential signaling properties of lactate, at rest or with exercise, have not been explored in human tissue. In a cross-over design study, 8 men and 8 women performed one-legged resistance exercise while receiving venous infusion of saline or sodium lactate. Blood was sampled repeatedly, and muscle biopsies were collected at rest and at 0, 90,180 min and 24 h after exercise. The primary outcomes examined were intracellular signaling, fractional protein synthesis rate (FSR), and blood/muscle levels of lactate and pH. Post-exercise blood lactate concentrations were 130% higher in the Lactate trial (3.0 vs 7.0 mmol×l-1, p<0.001) whereas muscle levels were only marginally higher (27 vs 32 mmol×kg-1 d.w., p=0.003) compared to the Saline-trial. Post-exercise blood pH was higher in the Lactate-trial (7.34 vs 7.44, p<0.001), with no differences in intramuscular pH. Exercise increased the phosphorylation of mTORS2448 (~40%), S6K1T389 (~3-fold), and p44T202/T204 (~80%) during recovery, without any differences between trials. FSR over the 24-h recovery period did not differ between the Saline (0.067 %/h) and Lactate (0.062 %/h) trials. This study does not support the hypothesis that blood lactate levels can modulate anabolic signaling in contracted human muscle. Further in vivo research investigating the impact of exercised versus rested muscle and the role of intramuscular lactate is needed to elucidate its potential signaling properties.
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| 45. |
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| 46. |
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| 47. |
- Lindberg, L, et al.
(författare)
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Obesity in childhood, socioeconomic status, and completion of 12 or more school years: a prospective cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:3, s. e040432-
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Tidskriftsartikel (refereegranskat)abstract
- Children with obesity achieve lower educational level compared with normal-weight peers. Parental socioeconomic status (SES) impacts both a child’s academic achievement and risk of obesity. The degree to which the association between obesity and education depends on parental SES is unclear. Therefore, the primary aim is to investigate if individuals with obesity in childhood are less likely to complete ≥12 years of schooling, independently of parental SES. The secondary aim is to study how weight loss, level of education and parental SES are associated.DesignNationwide prospective cohort study.SettingSwedish national register data.ParticipantsChildren aged 10–17 years, recorded in the Swedish Childhood Obesity Treatment Register, and aged 20 years or older at follow-up were included (n=3942). A comparison group was matched by sex, year of birth and living area (n=18 728). Parental SES was based on maternal and paternal level of education, income and occupational status.Primary outcome measureCompletion of ≥12 years of schooling was analysed with conditional logistic regression, and adjusted for group, migration background, attention deficit disorder with or without hyperactivity, anxiety/depression and parental SES.ResultsAmong those with obesity in childhood, 56.7% completed ≥12 school years compared with 74.4% in the comparison group (p<0.0001). High parental SES compared with low SES was strongly associated with attained level of education in both children with and without obesity, adjusted OR (aOR) (99% CI)=5.40 (4.45 to 6.55). However, obesity in childhood remains a strong risk factor of not completing ≥12 school years, independently of parental SES, aOR=0.57 (0.51 to 0.63). Successful obesity treatment increased the odds of completing ≥12 years in school even when taking parental SES into account, aOR=1.34 (1.04 to 1.72).ConclusionsIndividuals with obesity in childhood have lower odds of completing ≥12 school years, independently of parental SES. Optimised obesity treatment may improve school results in this group.
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| 48. |
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| 49. |
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| 50. |
- Lundby, Knut, et al.
(författare)
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Religion and the Media : Continuity, Complexity, and Mediatization
- 2018
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Ingår i: Religious Complexity in the Public Sphere. - Basingstoke : Palgrave Macmillan. - 9783319556772 - 9783319556789 ; , s. 137-191
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Bokkapitel (refereegranskat)abstract
- This chapter begins with a presentation of the particular features of the Nordic media systems and their transformations since 1980. The following analyzes three forms of mediatized religion: journalism on religion (in major newspapers), religion in popular media (popular magazines and films), and religious media (religious programs in the public service broadcasting and the Internet presentations by the Nordic majority churches). The conclusions show no simple pattern of a decline or resurgence of the visibility of religion in the media. This chapter also asks what the media do to religion (mediatization theory), and concludes that the media genre has a profound impact on the representation of religion, which results in a complex pattern of increased diversity of topics and perspectives.
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