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Sökning: WFRF:(Danila E)

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  • Borisov, S, et al. (författare)
  • Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report
  • 2019
  • Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 54:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The World Health Organization (WHO) recommends that countries implement pharmacovigilance and collect information on active drug safety monitoring (aDSM) and management of adverse events.The aim of this prospective study was to evaluate the frequency and severity of adverse events to anti-tuberculosis (TB) drugs in a cohort of consecutive TB patients treated with new (i.e. bedaquiline, delamanid) and repurposed (i.e. clofazimine, linezolid) drugs, based on the WHO aDSM project. Adverse events were collected prospectively after attribution to a specific drug together with demographic, bacteriological, radiological and clinical information at diagnosis and during therapy. This interim analysis included patients who completed or were still on treatment at time of data collection.Globally, 45 centres from 26 countries/regions reported 658 patients (68.7% male, 4.4% HIV co-infected) treated as follows: 87.7% with bedaquiline, 18.4% with delamanid (6.1% with both), 81.5% with linezolid and 32.4% with clofazimine. Overall, 504 adverse event episodes were reported: 447 (88.7%) were classified as minor (grade 1–2) and 57 (11.3%) as serious (grade 3–5). The majority of the 57 serious adverse events reported by 55 patients (51 out of 57, 89.5%) ultimately resolved. Among patients reporting serious adverse events, some drugs held responsible were discontinued: bedaquiline in 0.35% (two out of 577), delamanid in 0.8% (one out of 121), linezolid in 1.9% (10 out of 536) and clofazimine in 1.4% (three out of 213) of patients. Serious adverse events were reported in 6.9% (nine out of 131) of patients treated with amikacin, 0.4% (one out of 221) with ethionamide/prothionamide, 2.8% (15 out of 536) with linezolid and 1.8% (eight out of 498) with cycloserine/terizidone.The aDSM study provided valuable information, but implementation needs scaling-up to support patient-centred care.
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  • Abolfathi, Bela, et al. (författare)
  • The LSST DESC DC2 Simulated Sky Survey
  • 2021
  • Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 253:31
  • Tidskriftsartikel (refereegranskat)abstract
    • We describe the simulated sky survey underlying the second data challenge (DC2) carried out in preparation for analysis of the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) by the LSST Dark Energy Science Collaboration (LSST DESC). Significant connections across multiple science domains will be a hallmark of LSST; the DC2 program represents a unique modeling effort that stresses this interconnectivity in a way that has not been attempted before. This effort encompasses a full end-to-end approach: starting from a large N-body simulation, through setting up LSST-like observations including realistic cadences, through image simulations, and finally processing with Rubin's LSST Science Pipelines. This last step ensures that we generate data products resembling those to be delivered by the Rubin Observatory as closely as is currently possible. The simulated DC2 sky survey covers six optical bands in a wide-fast-deep area of approximately 300 deg2, as well as a deep drilling field of approximately 1 deg2. We simulate 5 yr of the planned 10 yr survey. The DC2 sky survey has multiple purposes. First, the LSST DESC working groups can use the data set to develop a range of DESC analysis pipelines to prepare for the advent of actual data. Second, it serves as a realistic test bed for the image processing software under development for LSST by the Rubin Observatory. In particular, simulated data provide a controlled way to investigate certain image-level systematic effects. Finally, the DC2 sky survey enables the exploration of new scientific ideas in both static and time domain cosmology.
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  • Danila, DC, et al. (författare)
  • Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer
  • 2007
  • Ingår i: Clinical Cancer Research. - 1078-0432. ; 13:23, s. 7053-7058
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The development of tumor-specific markers to select targeted therapies and to assess clinical outcome remains a significant area of unmet need. We evaluated the association of baseline circulating tumor cell (CTC) number with clinical characteristics and survival in patients with castrate metastatic disease considered for different hormonal and cytotoxic therapies. EXPERIMENTAL DESIGN: CTC were isolated by immunomagnetic capture from 7.5-mL samples of blood from 120 patients with progressive clinical castrate metastatic disease. We estimated the probability of survival over time by the Kaplan-Meier method. The concordance probability estimate was used to gauge the discriminatory strength of the informative prognostic factors. RESULTS: Sixty-nine (57%) patients had five or more CTC whereas 30 (25%) had two cells or less. Higher CTC numbers were observed in patients with bone metastases relative to those with soft tissue disease and in patients who had received prior cytotoxic chemotherapy relative to those who had not. CTC counts were modestly correlated to measurements of tumor burden such as prostate-specific antigen and bone scan index, reflecting the percentage of boney skeleton involved with tumor. Baseline CTC number was strongly associated with survival, without a threshold effect, which increased further when baseline prostate-specific antigen and albumin were included. CONCLUSIONS: Baseline CTC was predictive of survival, with no threshold effect. The shedding of cells into the circulation represents an intrinsic property of the tumor, distinct from extent of disease, and provides unique information relative to prognosis.
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  • Danila, Uliana (författare)
  • Mold2012 : a new gravimetric quasigeoid model over Moldova
  • 2012
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In order to be able to use the operational Moldavian GNSS Positioning System MOLDPOS efficiently for the determination of normal heights in surveying engineering, e.g. during the construction of a road, an accurate quasigeoid model is needed. The main goal of this thesis is to present a new gravimetric quasigeoid model for Moldova (Mold2012), which has been determined by applying the Least Squares Modification of Stokes’ formula with Additive corrections (LSMSA), also called the KTH method. Due to limited coverage of gravity data, the integration area is often limited to a small spherical cap around the computation point, which leads to a truncation error for geoid height. Molodensky et al. (1962) showed that the truncation error can be reduced by the modification of Stokes’ formula, where the measured gravity data are combined with the low-frequency component of the geoid from a Global Gravitational Model (GGM). The LSMSA technique combines the GGM and the terrestrial data in an optimum way.In order to find the most suitable modification approach or cap size it is necessary to compare the gravimetric height anomalies with the GPS/levelling derived height anomalies, and for this purpose we use a GPS/levelling dataset that consists of 1042 points with geodetic coordinates in the MOLDREF99 reference system and normal heights at the same points given in the height system Baltic 77.The magnitude of the additive corrections varies within an interval from -0.6 cm to -4.3 cm over the area of Moldova. The quasigeoid model which results from combining the ITG-Grace02s solution (with n = M = 170, ψ0 = 3° and σΔg = 10 mGal) and the solution obtained from the modified Stokes’ formula together with the additive correction gives the best fit for the GPS/levelling data with a standard deviation (STD) of ±7.8 cm. The evaluation of the computed gravimetric quasigeoid is performed by comparing the gravimetric height anomalies with the GPS/levelling derived height anomalies for 1042 points.However, the above heterogeneous data include outliers, and in order to find and eliminate these, a corrector surface model is used. This surface provides a connection to the local vertical when the GNSS technique is used. After the elimination of the suspicious outliers (170 points) according to a 2-RMS test, a new corrective surface was computed based on the remaining 872 GPS/levelling points, and the STD of residuals became ±4.9 cm. The STD value for the residuals according to the order of the levelling network for the Mold2012 fitted to the local vertical datum is 3.8 cm for the I-order, 4.3 cm for the II-order, 4.5 cm for the III-order and 5.0 cm for the IV-order levelling network. But the STD of the residuals for the 18 control points indicates a better result where the STD is 3.6 cm and RMS is 3.9 cm and the min and max value of residuals is -5.3 cm and 9.0 cm, respectively.As the STD of the differences in height anomaly are not just the standard error of the height anomalies (quasigeoid model), but it contains also the standard errors of GPS heights and of normal heights. Assuming that the latter STDs are 3 cm and 3.5 cm, respectively, the STD of Mold2012 is estimated to 1.7 cm.
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  • Izadi, Zara, et al. (författare)
  • Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease : an observational study
  • 2022
  • Ingår i: The Lancet Rheumatology. - : Elsevier. - 2665-9913. ; 4:9, s. e603-e613
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.Methods: In this observational study, we derived individual-level data on adults (aged 18–99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.Findings: 14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m3 [95% CI 1·01–1·17]; p=0·0105), proportion of the population aged 65 years or older (1·19 per 1% increase [1·10–1·30]; p<0·0001), and population mobility (1·03 per 1% increase in number of visits to grocery and pharmacy stores [1·02–1·05]; p<0·0001 and 1·02 per 1% increase in number of visits to workplaces [1·00–1·03]; p=0·032) were independently associated with higher odds of mortality. Number of hospital beds (0·94 per 1-unit increase per 1000 people [0·88–1·00]; p=0·046), human development index (0·65 per 0·1-unit increase [0·44–0·96]; p=0·032), government response stringency (0·83 per 10-unit increase in containment index [0·74–0·93]; p=0·0018), as well as follow-up time (0·78 per month [0·69–0·88]; p<0·0001) were independently associated with lower odds of mortality. These factors sufficiently explained country-level variations in death attributable to COVID-19 (intraclass correlation coefficient 1·2% [0·1–9·5]; p=0·14).Interpretation: Our findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities.
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  • Miehlke, Stephan, et al. (författare)
  • European guidelines on microscopic colitis : United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations
  • 2021
  • Ingår i: United European Gastroenterology journal. - : Sage Publications. - 2050-6406 .- 2050-6414. ; 9:1, s. 13-37
  • Forskningsöversikt (refereegranskat)abstract
    • Introduction: Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, non-bloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for evidence-based guidelines to improve the medical care of patients suffering from this disorder.Methods: Guidelines were developed by members from the European Microscopic Colitis Group and United European Gastroenterology in accordance with the Appraisal of Guidelines for Research and Evaluation II instrument. Following a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the certainty of the evidence. Statements and recommendations were developed by working groups consisting of gastroenterologists, pathologists and basic scientists, and voted upon using the Delphi method.Results: These guidelines provide information on epidemiology and risk factors of microscopic colitis, as well as evidence-based statements and recommendations on diagnostic criteria and treatment options, including oral budesonide, bile acid binders, immunomodulators and biologics. Recommendations on the clinical management of microscopic colitis are provided based on evidence, expert opinion and best clinical practice.Conclusion: These guidelines may support clinicians worldwide to improve the clinical management of patients with microscopic colitis.
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  • Moraisde Carvalho, Danila, et al. (författare)
  • Assessment of chemical transformations in eucalyptus, sugarcane bagasse and straw during hydrothermal, dilute acid, and alkaline pretreatments
  • 2015
  • Ingår i: Industrial crops and products (Print). - : Elsevier BV. - 0926-6690 .- 1872-633X. ; 73, s. 118-126
  • Tidskriftsartikel (refereegranskat)abstract
    • The impact of hydrothermal, dilute acid, and alkaline pretreatments on the chemical structure of eucalyptus, sugarcane bagasse, and straw were compared with a view to their subsequent bioconversion into ethanol. Sugarcane bagasse and straw contain high amounts of extractives (15.0% and 12.2%, respectively), ash (2.3% and 7.9%, respectively), and silica (1.4% and 5.8%, respectively). If not properly corrected, the presence of silica would lead to the overestimation of the lignin, while high amounts of extractives would cause the overestimation of the content of sugars in biomass. Applying a novel approach through the use of complete mass balance, bagasse and straw were proven to contain lower amounts of lignin (18.0% and 13.9%, respectively) than previously reported for these raw materials, and certainly a much lower amount of lignin than eucalyptus (27.4%). The syringyl to guaiacyl units ratio (SIG) for lignin in bagasse and straw (1.1 and 0.5, respectively) was lower than that for eucalyptus (2.7), indicating a different reactivity during chemical pretreatments. The xylan content in sugarcane bagasse and straw was much higher than that in eucalyptus, with a significantly lower degree of substitution for uronic acids and acetyl groups. The sugarcane straw showed the highest mass loss during the investigated pretreatments, especially under alkaline conditions, with a total biomass yield of only 37.3%. During the hydrothermal and dilute acid treatments, mostly hemicelluloses were removed, followed by the formation a significant amount of pseudo-lignin structures, while the alkaline pretreatment affected the lignin content. With eucalyptus, the formation of structures similar in their behavior to extractives (i.e., soluble in toluene and ethanol, subsequently referred to as "pseudo-extractives") was observed during all three pretreatments, with 12.4% for hydrothermal, 18.9% for dilute acid, and 8.7% for alkaline pretreatment. This information, combined with actual yields, should be taken into account when assessing the impact of pretreatments on the chemical composition and structure of biomass.
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  • Prusakov, Pavel, et al. (författare)
  • A global point prevalence survey of antimicrobial use in neonatal intensive care units : The no-more-antibiotics and resistance (NO-MAS-R) study
  • 2021
  • Ingår i: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 32
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts.Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality.Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0-100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received >= 1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were "rule-out" sepsis (32%) and "culture-negative" sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and "culture-negative" infections was 12 days (median; IQR, 8-14) and 7 days (median; IQR, 5-10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0.02).Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide.
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  • Verhaegh, Bas P. M., et al. (författare)
  • Course of disease in patients with microscopic colitis : a European prospective incident cohort study
  • 2021
  • Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 15:7, s. 1174-1183
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND AIMS: The disease course of microscopic colitis (MC) is considered chronic but benign. However, this assumption is based on mainly retrospective studies, reporting on incomplete follow-up of selective cohorts. Systematic, prospective and unbiased data to inform patients and health care professionals on the expected course of the disease and real-life response to therapy are warranted.METHODS: A prospective, pan-European, multi-center, web-based registry was established. Incident cases of MC were included. Data on patient characteristics, symptoms, treatment and quality of life were systematically registered at baseline and during real-time follow-up. Four disease course phenotypes were discriminated and described.RESULTS: Among 381 cases with complete 1-year follow-up, 49% had a chronic active or relapsing disease course, 40% achieved sustained remission after treatment and 11% had a quiescent course. In general, symptoms and quality of life improved after 3 months of follow-up. A relapsing or chronic active disease course was associated with significantly more symptoms and impaired quality of life after 1 year.CONCLUSIONS: A minority of MC patients follow a quiescent disease course with spontaneous clinical improvement, whereas the majority suffers a chronic active or relapsing disease course during the first year after diagnosis, with persisting symptoms accompanied by a significantly impaired quality of life.
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