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Sökning: WFRF:(Dantan Luc)

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1.
  • Fallet, Manon, 1992-, et al. (författare)
  • Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
  • 2022
  • Ingår i: Microbiome. - : BioMed Central (BMC). - 2049-2618. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation — and, importantly, protection from infectious disease — is still an open question.Results: Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.Conclusions: We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease
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2.
  • Morse, Edward, et al. (författare)
  • Tolerancing: Managing uncertainty from conceptual design to final product
  • 2018
  • Ingår i: CIRP Annals - Manufacturing Technology. - : Elsevier BV. - 1726-0604 .- 0007-8506. ; 67:2, s. 695-717
  • Tidskriftsartikel (refereegranskat)abstract
    • Variability is unavoidable in the realization of products. While design must specify ideal geometry, it shall also describe limits of variability (tolerances) that must be met in order to maintain proper product function. Although tolerancing is a mature field, new manufacturing processes and design methodologies are creating new avenues of research, and modelling standards must also evolve to support these processes. In addition, the study of uncertainty has produced widely-accepted methods of quantifying variability, and modern tolerancing tools should support these methods. The challenges introduced by new processes and design methodologies continue to make tolerancing research a fertile and productive area.
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