↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Darstein C.) "

Search: WFRF:(Darstein C.)

Result 1-4 of 4

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Glimelius, Bengt, et al. (author) A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer 2010 In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 21:5, s. 1020-1026 Journal article (peer-reviewed)abstract BACKGROUND: Preclinically, protein kinase C and AKT activation can be inhibited by enzastaurin and reduce tumor growth of colorectal cancer cells. In asymptomatic patients with metastatic colorectal cancer (mCRC), enzastaurin activity was evaluated by measuring the 6-month progression-free survival (PFS) rate in a window study design. PATIENTS AND METHODS: Chemonaive patients with asymptomatic mCRC who did not require immediate chemotherapy-induced tumor reduction received a 400-mg thrice daily loading dose of enzastaurin on day 1 of cycle 1, followed by 500 mg once daily for the remaining 28-day cycles. Progression was assessed on the basis of radiographic imaging, rise in carcinoembryonic antigen or lactate dehydrogenase (LDH) levels or by appearance of clinical symptoms. RESULTS: Twenty-eight patients received daily enzastaurin. The 6-month PFS rate was 28% [95% confidence interval (CI) 13%-45%] and median PFS was 1.9 months (95% CI 1.8-4.5 months). Twelve (43%) patients had stable disease with a median duration of 6.1 months. The survival rate at 20 months was 77% (95% CI 47%-92%). No grade 4 toxicity was reported and grade 3 toxic effects were observed in three patients with one patient showing probable drug-related elevation of liver transaminases. CONCLUSION: The window design in asymptomatic patients with mCRC can be safely applied to assess the activity and safety of novel cytostatic agents like enzastaurin.
2.	Wallentin, LC, et al. (author) Prasugrel (CS-747), a novel thienopyridine P2Y12 receptor antagonist, results in more effective platelet inhibition than clopidogrel in aspirin-treated patients with atherosclerotic disease 2005 In: EUROPEAN HEART JOURNAL. - 0195-668X. ; 26, s. 488-488 Conference paper (other academic/artistic)
3.	Wallentin, L, et al. (author) Inhibition of platelet aggregation with prasugrel (CS-747, LY640315), a novel thanopyridine P2Y(12) receptor antagonist, compared with clopidogrel in aspirin-treated patients with atherosclerotic vascular disease 2005 In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - 0735-1097. ; 45:3, s. 416A-416A Conference paper (other academic/artistic)
4.	Winters, KJ, et al. (author) Prasugrel (CS-747) achieves significantly higher inhibition of platelet aggregation and a lower rate of nonresponders compared with clopidogrel in aspirin-treated patients with atherosclerotic vascular disease 2005 In: AMERICAN JOURNAL OF CARDIOLOGY. - 0002-9149. ; 96:7A, s. 154H-154H Conference paper (other academic/artistic)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-4 of 4

Refine your search

Type of publication: conference paper (3); journal article (1)

Type of content: other academic/artistic (3); peer-reviewed (1)

Author/Editor: Darstein, C. (4); Jernberg, T (3); Siegbahn, A (3); Leese, PT (3); Winters, KJ (3); Wallentin, L (2); show more...; Nilsson, LG (2); Payne, CD (2); Brandt, JT (2); Jakubowski, JA (2); Liu, Y. (1); Glimelius, Bengt (1); Payne, C (1); Berglund, Åke (1); Pfeiffer, P (1); Jakobsen, A (1); Wallentin, LC (1); Byström, P. (1); Frödin, J-E. (1); Lahn, M (1); Qvortrup, C. (1); Gawande, S (1); Musib, L (1); Cleverly, A. (1); Spindler, K. L. (1); Naganuma, H (1); show less...

University: Karolinska Institutet (4); Uppsala University (1)

Language: English (4)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view