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2.
  • Abdellaoui, G., et al. (författare)
  • Meteor studies in the framework of the JEM-EUSO program
  • 2017
  • Ingår i: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 143, s. 245-255
  • Tidskriftsartikel (refereegranskat)abstract
    • We summarize the state of the art of a program of UV observations from space of meteor phenomena, a secondary objective of the JEM-EUSO international collaboration. Our preliminary analysis indicates that JEM-EUSO, taking advantage of its large FOV and good sensitivity, should be able to detect meteors down to absolute magnitude close to 7. This means that JEM-EUSO should be able to record a statistically significant flux of meteors, including both sporadic ones, and events produced by different meteor streams. Being unaffected by adverse weather conditions, JEM-EUSO can also be a very important facility for the detection of bright meteors and fireballs, as these events can be detected even in conditions of very high sky background. In the case of bright events, moreover, exhibiting some persistence of the meteor train, preliminary simulations show that it should be possible to exploit the motion of the ISS itself and derive at least a rough 3D reconstruction of the meteor trajectory. Moreover, the observing strategy developed to detect meteors may also be applied to the detection of nuclearites, exotic particles whose existence has been suggested by some theoretical investigations. Nuclearites are expected to move at higher velocities than meteoroids, and to exhibit a wider range of possible trajectories, including particles moving upward after crossing the Earth. Some pilot studies, including the approved Mini-EUSO mission, a precursor of JEM-EUSO, are currently operational or in preparation. We are doing simulations to assess the performance of Mini-EUSO for meteor studies, while a few meteor events have been already detected using the ground-based facility EUSO-TA.
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3.
  • Abdellaoui, G., et al. (författare)
  • First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
  • 2018
  • Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 13
  • Tidskriftsartikel (refereegranskat)abstract
    • EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25(th) of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector.
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  • Elhai, M, et al. (författare)
  • Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
  • 2019
  • Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 78:7, s. 979-987
  • Tidskriftsartikel (refereegranskat)abstract
    • To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
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8.
  • Horwich, A, et al. (författare)
  • EAU–ESMO consensus statements on the management of advanced and variant bladder cancer - an international collaborative multi-stakeholder effort : under the auspices of the EAU and ESMO Guidelines Committees
  • 2019
  • Ingår i: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 30:11, s. 1697-1727
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference.SETTING: Online Delphi survey and consensus conference.PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus).RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease and the evolving role of checkpoint inhibitor therapy in metastatic disease.CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time where further evidence is available to guide our approach.
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9.
  • Adriani, O., et al. (författare)
  • A statistical procedure for the identification of positrons in the PAMELA experiment
  • 2010
  • Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 34:1, s. 1-11
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA satellite experiment has measured the cosmic-ray positron fraction between 1.5 GeV and 100 GeV. The need to reliably discriminate between the positron signal and proton background has required the development of an ad hoc analysis procedure. In this paper, a method for positron identification is described and its stability and capability to yield a correct background estimate is shown. The analysis includes new experimental data, the application of three different fitting techniques for the background sample and an estimate of systematic uncertainties due to possible inaccuracies in the background selection. The new experimental results confirm both solar modulation effects on cosmic-rays with low rigidities and an anomalous positron abundance above 10 GeV. (c) 2010 Elsevier B.V. All rights reserved.
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10.
  • Amelino-Camelia, G., et al. (författare)
  • Physics with the KLOE-2 experiment at the upgraded DA Phi NE
  • 2010
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 68:3-4, s. 619-681
  • Forskningsöversikt (refereegranskat)abstract
    • Investigation at a f-factory can shed light on several debated issues in particle physics. We discuss: (i) recent theoretical development and experimental progress in kaon physics relevant for the Standard Model tests in the flavor sector, (ii) the sensitivity we can reach in probing CPT and Quantum Mechanics from time evolution of entangled-kaon states, (iii) the interest for improving on the present measurements of non-leptonic and radiative decays of kaons and eta/eta' mesons, (iv) the contribution to understand the nature of light scalar mesons, and (v) the opportunity to search for narrow di-lepton resonances suggested by recent models proposing a hidden dark-matter sector. We also report on the e(+)e(-) physics in the continuum with the measurements of (multi) hadronic cross sections and the study of gamma gamma processes.
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11.
  • De Simone, N., et al. (författare)
  • Latitudinal and radial gradients of galactic cosmic ray protons in the inner heliosphere - PAMELA and Ulysses observations
  • 2011
  • Ingår i: Astrophysics and Space Sciences Transactions (ASTRA). - : Copernicus GmbH. - 1810-6528 .- 1810-6536. ; 7:3, s. 425-434
  • Tidskriftsartikel (refereegranskat)abstract
    • Ulysses, launched on 6 October 1990, was placed in an elliptical, high inclined (80.2°) orbit around the Sun, and was switched off in June 2009. It has been the only spacecraft exploring high-latitude regions of the inner heliosphere. The Kiel Electron Telescope (KET) aboard Ulysses measures electrons from 3 MeV to a few GeV and protons and helium in the energy range from 6 MeV/nucleon to above 2 GeV/nucleon. The PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) space borne experiment was launched on 15 June 2006 and is continuously collecting data since then. The apparatus measures electrons, positrons, protons, anti-protons and heavier nuclei from about 100 MeV to several hundreds of GeV. Thus the combination of Ulysses and PAMELA measurements is ideally suited to determine the spatial gradients during the extended minimum of solar cycle 23. For protons in the rigidity interval 1.6-1.8 GV we find a radial gradient of 2.7%/AU and a latitudinal gradient of -0.024%/degree. Although the latitudinal gradient is as expected negative, its value is much smaller than predicted by current particle propagation models. This result is of relevance for the study of propagation parameters in the inner heliosphere.
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13.
  • Witjes, J. Alfred, et al. (författare)
  • EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer – An International Collaborative Multistakeholder Effort : Under the Auspices of the EAU-ESMO Guidelines Committees
  • 2020
  • Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 77:2, s. 223-250
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts prior to voting during a consensus conference.SETTING: Online Delphi survey and consensus conference.PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), and 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus).RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these statements, 33 (28%) achieved level 1 consensus and 49 (42%) achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease, and the evolving role of checkpoint inhibitor therapy in metastatic disease.CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time when further evidence is available to guide our approach.PATIENT SUMMARY: This report summarises findings from an international, multistakeholder project organised by the EAU and ESMO. In this project, a steering committee identified areas of bladder cancer management where there is currently no good-quality evidence to guide treatment decisions. From this, they developed a series of proposed statements, 71 of which achieved consensus by a large group of experts in the field of bladder cancer. It is anticipated that these statements will provide further guidance to health care professionals and could help improve patient outcomes until a time when good-quality evidence is available.
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14.
  • Adriani, O., et al. (författare)
  • Latest results from the Pamela experiment
  • 2009
  • Ingår i: Proceedings of Science. ; , s. 1-6
  • Konferensbidrag (refereegranskat)abstract
    • In this paper we present the latest results of the Pamela satellite experiment, focusing in particular on the p̄/p and the e +/(e+ +e-) ratios.
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15.
  • Adriani, O., et al. (författare)
  • Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
  • 2013
  • Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
  • Tidskriftsartikel (refereegranskat)abstract
    • It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
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16.
  • Adriani, O., et al. (författare)
  • Measurements of quasi-trapped electron and positron fluxes with PAMELA
  • 2009
  • Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114, s. A12218-
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents precise measurements of the differential energy spectra of quasi-trapped secondary electrons and positrons and their ratio between 80 MeV and 10 GeV in the near-equatorial region (altitudes between 350 km and 600 km). Latitudinal dependences of the spectra are analyzed in detail. The results were obtained from July until November 2006 onboard the Resurs-DK satellite by the PAMELA spectrometer, a general purpose cosmic ray detector system built around a permanent magnet spectrometer and a silicon-tungsten calorimeter.
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17.
  • Adriani, O., et al. (författare)
  • OBSERVATIONS OF THE 2006 DECEMBER 13 AND 14 SOLAR PARTICLE EVENTS IN THE 80 MeV n(-1)-3 GeV n(-1) RANGE FROM SPACE WITH THE PAMELA DETECTOR
  • 2011
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 742:2, s. 102-
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the space spectrometer PAMELA observations of proton and helium fluxes during the 2006 December 13 and 14 solar particle events. This is the first direct measurement of the solar energetic particles in space with a single instrument in the energy range from similar to 80 MeV n(-1) up to similar to 3 GeV n(-1). For the December 13 event, measured energy spectra of solar protons and helium are compared with results obtained by neutron monitors and other detectors. Our measurements show a spectral behavior different from those derived from the neutron monitor network. No satisfactory analytical fitting was found for the energy spectra. During the first hours of the December 13 event, solar energetic particles spectra were close to the exponential form, demonstrating rather significant temporal evolution. Solar He with energy up to 1 GeV n(-1) was recorded on December 13. For the December 14 event, energy of solar protons reached 600 MeV, whereas the maximum energy of He was below 100 MeV n(-1). The spectra were slightly bent in the lower energy range and preserved their form during the second event. Differences in the particle flux appearance and temporal evolution of these two events may argue for special conditions leading to the acceleration of solar particles up to relativistic energies.
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18.
  • Adriani, O., et al. (författare)
  • PAMELA Measurements of Cosmic-Ray Proton and Helium Spectra
  • 2011
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 332:6025, s. 69-72
  • Tidskriftsartikel (refereegranskat)abstract
    • Protons and helium nuclei are the most abundant components of the cosmic radiation. Precise measurements of their fluxes are needed to understand the acceleration and subsequent propagation of cosmic rays in our Galaxy. We report precision measurements of the proton and helium spectra in the rigidity range 1 gigavolt to 1.2 teravolts performed by the satellite-borne experiment PAMELA (payload for antimatter matter exploration and light-nuclei astrophysics). We find that the spectral shapes of these two species are different and cannot be described well by a single power law. These data challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. More complex processes of acceleration and propagation of cosmic rays are required to explain the spectral structures observed in our data.
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19.
  • Adriani, O., et al. (författare)
  • PAMELA Results on the Cosmic-Ray Antiproton Flux from 60 MeV to 180 GeV in Kinetic Energy
  • 2010
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:12, s. 121101-
  • Tidskriftsartikel (refereegranskat)abstract
    • The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray antiproton flux and the antiproton-to-proton flux ratio which extends previously published measurements down to 60 MeV and up to 180 GeV in kinetic energy. During 850 days of data acquisition approximately 1500 antiprotons were observed. The measurements are consistent with purely secondary production of antiprotons in the Galaxy. More precise secondary production models are required for a complete interpretation of the results.
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20.
  • Babusci, D., et al. (författare)
  • Precision measurement of sigma (e(+)e(-) -> pi(+)pi(-)gamma)/sigma(e(+)e(-) ->mu(+)mu(-)gamma) and determination of the pi(+)pi(-) contribution to the muon anomaly with the KLOE detector
  • 2013
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 720:4-5, s. 336-343
  • Tidskriftsartikel (refereegranskat)abstract
    • We have measured the ratio cr (e(+)e(-) -> pi(+)pi(-)gamma)/sigma(e(+)e(-) -> mu(+)mu(-)gamma), with the KLOE detector at DA Phi NE for a total integrated luminosity of similar to 240 pb(-1). From this ratio we obtain the cross section sigma (e(+)e(-) -> pi(+)pi(-)gamma). From the cross section we determine the pion form factor vertical bar F-pi vertical bar(2) and the two-pion contribution to the muon anomaly a(mu) for 0.592< M-pi pi < 0.975 GeV, Delta(pi pi) a(mu) = (385.1 +/- 1.1(stat) +/- 2.7(sys+theo)) x 10(-10). This result confirms the current discrepancy between the Standard Model calculation and the experimental measurement of the muon anomaly. (c) 2013 Elsevier B.V. All rights reserved.
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21.
  • Babusci, D., et al. (författare)
  • Search for light vector boson production in e(+)e(-) -> mu(+)mu(-)gamma interactions with the KLOE experiment
  • 2014
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 736, s. 459-464
  • Tidskriftsartikel (refereegranskat)abstract
    • We have searched for a light vector boson U, the possible carrier of a "dark force", with the KLOE detector at the DA Phi NE e(+)e(-) collider, motivated by astrophysical evidence for the presence of dark matter in the Universe. Using e(+)e(-) collisions collected with an integrated luminosity of 239.3 pb(-1), we look for a dimuon mass peak in the reaction e(+)e(-) -> mu(+)mu(-)gamma, corresponding to the decay U -> mu(+)mu(-). We find no evidence for a U vector boson signal. We set a 90% CL upper limit for the mixing parameter squared between the photon and the U boson of 1.6 x 10(-5) to 8.6 x 10(-7) for the mass region 520 < m(U) < 980 MeV.  
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22.
  • Babusci, D., et al. (författare)
  • Test of CPT and Lorentz symmetry in entangled neutral kaons with the KLOE experiment
  • 2014
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 730, s. 89-94
  • Tidskriftsartikel (refereegranskat)abstract
    • Neutral kaon pairs produced in phi decays in anti-symmetric entangled state can be exploited to search for violation of CPT symmetry and Lorentz invariance. We present an analysis of the CP-violating process phi -> KSKL -> pi(+)pi(-)pi(+)pi(-) based on 1.7 fb(-1) of data collected by the KLOE experiment at the Frascati phi-factory DA Phi NE. The data are used to perform a Measurement of the CPT-violating parameters Delta a(mu) for neutral kaons in the context of the Standard Model Extension framework. The parameters measured in the reference frame of the fixed stars are: Delta a(0) = (-6.0 +/- 7.7(stat)+/- 3.1(syst)) X 10(-18) GeV, Delta a(x) = (0.9 +/- 1.5(stat)+/- 0.6(syst)) X 10(-18) GeV, Delta a(y) = (-2.0 +/- 1.5(stat)+/- 0.5(syst)) X 10(-18) GeV, Delta a(z) = (3.1 +/- 1.7(stat)+/- 0.5(syst)) X 10(-18) GeV. These are presently the most precise measurements in the quark sector of the Standard Model Extension. (C) 2014 The Authors. Published by Elsevier B.V.
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24.
  • Bazilevskaya, G. A., et al. (författare)
  • Solar proton events at the end of the 23rd and start of the 24th solar cycle recorded in the PAMELA experiment
  • 2013
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 493-496
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA magnetic spectrometer was launched into a near-Earth orbit on board the Resurs-DK1 satellite in June 2006; in December 2006, it recorded the last strong solar high-energy particle event of the 23rd solar cycle. A deficit was thereafter observed in solar energetic particle events because of the lengthy solar activity minimum and the weak evolution of the next (24th) solar cycle. As a result, only a few solar events involving protons with energies of more than 100 MeV were recorded between 2010 and 1012. This work presents the preliminary results from measurements of charged particle fluxes in these events, recorded by the Pamela spectrometer.
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25.
  • Boezio, M., et al. (författare)
  • PAMELA and indirect dark matter searches
  • 2009
  • Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 11, s. 105023-
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a review of the experimental results obtained by PAMELA in measuring the (p, (p) over bar ) and e(+/-) abundance in cosmic rays. In this context, we discuss the interpretation of the observed anomalous positron excess in terms of the annihilation of dark matter particles as well as in terms of standard astrophysical sources. Moreover we show the constraints on dark matter models from (p) over bar data.
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26.
  • De Simone, N., et al. (författare)
  • Comparison of models and measurements of protons of trapped and secondary origin with PAMELA experiment
  • 2009
  • Ingår i: 31st International Cosmic Ray Conference, ICRC 2009. - : University of Lodz.
  • Konferensbidrag (refereegranskat)abstract
    • PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature in a wide energy range (protons: 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study of the antimatter component: Antiprotons (80 MeV-190 GeV), positrons (50 MeV-270 GeV) and search for antinuclei with a precision of the order of 10-8). The experiment, housed on board the Russian Resurs- DK1 satellite, was launched on June, 15th 2006 in a 350x600 km orbit with an inclination of 70 degrees. In this work we present the measurement of galactic and reentrant albedo proton spectra in the energy range between 100 MeV and 300 GeV. The galactic protons refer to the period 2006-2008, showing evidence of Solar modulation effects even during the solar minimum.
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28.
  • Mayorov, A. G., et al. (författare)
  • Antiprotons of galactic cosmic radiation in the PAMELA experiment
  • 2013
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 602-605
  • Tidskriftsartikel (refereegranskat)abstract
    • A method for antiproton selection against a background of electrons, based on a mathematical model of data classification using variations in interparticle interaction in a calorimeter, and a method for excluding events accompanied by scattering in the inner detectors of a tracking system (which result in errors in the measured trajectory's curvature and charge sign) from analysis are discussed in this paper. Antiproton spectra and antiproton/proton flux ratio at energies of 0.06 to 350 GeV with statistics of events surpassing those in [1] are obtained. The results can be used to create models for the generation and distribution of particles in the Galaxy, and for searching and studying the nature of hypothetical dark matter particles.
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29.
  • Menn, W., et al. (författare)
  • The PAMELA space experiment
  • 2013
  • Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 209-218
  • Tidskriftsartikel (refereegranskat)abstract
    • On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus is comprised of a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail counter scintillator and a neutron detector. The combination of these devices allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV to 100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectra in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (anti-helium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA is investigating phenomena connected with solar and earth physics. After 4 years of operation in flight, PAMELA is now delivering coherent results about spectra and chemical composition of the charged cosmic radiation, allowing scenarios of production and propagation of cosmic rays to be fully established and understood.
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30.
  • Mocchiutti, E., et al. (författare)
  • Precision studies of cosmic rays with the PAMELA satellite experiment
  • 2009
  • Ingår i: 2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5. - : IEEE. - 9781424439621 ; , s. 2125-2130
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA satellite experiment was launched into low earth orbit on June 15th 2006. The combination of a permanent magnet silicon strip spectrometer, and a silicon-tungsten imaging calorimeter allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - 200 GeV). A primary scientific goal is to search for dark matter particle annihilations by measuring the energy spectra of cosmic ray antiparticles. Latest results from the PAMELA experiment will be reviewed with a particular focus on cosmic ray antiprotons and positrons. The status of PAMELA measurements for other cosmic ray species will also be reviewed.
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31.
  • Mocchiutti, E., et al. (författare)
  • Results from PAMELA
  • 2011
  • Ingår i: NUCL PHYS B-PROC SUP. - : Elsevier BV. ; , s. 243-248
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA satellite experiment was launched into low earth orbit on June 15(th) 2006. The combination of a permanent magnet silicon strip spectrometer and a silicon-tungsten imaging calorimeter allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - several hundred GeV). A primary scientific goal is to search for dark matter particle annihilation by measuring the energy spectra of cosmic ray antiparticles. Latest results from the PAMELA experiment are presented with a particular focus on cosmic ray antiprotons and positrons.
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32.
  • Picozza, P., et al. (författare)
  • Cosmic ray studies with PAMELA experiment
  • 2011
  • Ingår i: Proceedings of the 14th Lomonosov Conference on Elementary Particle Physics: Particle Physics at the Year of Astronomy. - 9814329673 - 9789814329675 ; , s. 200-206
  • Konferensbidrag (refereegranskat)abstract
    • The instrument PAMELA, in orbit since June 15th, 2006 on board of the Russian satellite Resurs DK1, is daily delivering to ground 16 Gigabytes of data. The apparatus is designed to study charged particles in the cosmic radiation, with a particular focus on antiparticles for searching antimatter and signals of dark matter annihilation. A combination of a magnetic spectrometer and different detectors allows antiparticles to be reliably identified from a large background of other charged particles. New results on the antiproton-to-proton and positron-toall electron ratios over a wideenergy range (1-100 GeV) have been obtained from the PAMELA mission. These data are mainly interpreted in terms of dark matter annihilation or pulsar contribution.
  •  
33.
  •  
34.
  • Adriani, O., et al. (författare)
  • Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
  • 2013
  • Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
  •  
35.
  • Adriani, O., et al. (författare)
  • The PAMELA Space Mission for Antimatter and Dark Matter Searches in Cosmic Rays
  • 2010
  • Ingår i: SCIENCE WITH THE NEW GENERATION OF HIGH-ENERGY GAMMA-RAY EXPERIMENTS. - : AIP. - 9780735407671 ; , s. 33-42
  • Konferensbidrag (refereegranskat)abstract
    • On the 15(th) of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The instrument allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - 100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectrum in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (anti-helium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA is investigating phenomena connected with solar and earth physics. Results of the antiproton and positron data will be presented.
  •  
36.
  •  
37.
  • Anastasi, A., et al. (författare)
  • Combination of KLOE sigma (e(+) e(-) -> pi(+)pi(-) gamma(gamma)) measurements and determination of a(mu)(pi+pi-) in the energy range 0.10 < s < 0.95 GeV2
  • 2018
  • Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :3
  • Tidskriftsartikel (refereegranskat)abstract
    • The three precision measurements of the cross section sigma (e(+)e(-) -> pi(+)pi(-)gamma(gamma)) using initial state radiation by the KLOE collaboration provide an important input for the prediction of the hadronic contribution to the anomalous magnetic moment of the muon. These measurements are correlated for both statistical and systematic uncertainties and, therefore, the simultaneous use of these measurements requires covariance matrices that fully describe the correlations. We present the construction of these covariance matrices and use them to determine a combined KLOE measurement for sigma (e(+)e(-) -> pi(+)pi(-)gamma(gamma)). We find, from this combination, a two-pion contribution to the muon magnetic anomaly in the energy range 0.10 < s < 0.95 GeV2 of a(mu)(pi+pi-) (489.8 +/- 1.7(stat) +/- 4.8(sys)) x 10(-10).
  •  
38.
  • Anastasi, A., et al. (författare)
  • Combined limit on the production of a light gauge boson decaying into mu(+) mu(-) and pi(+) pi(-)
  • 2018
  • Ingår i: Physics Letters B. - : ELSEVIER SCIENCE BV. - 0370-2693 .- 1873-2445. ; 784, s. 336-341
  • Tidskriftsartikel (refereegranskat)abstract
    • We searched for the mu(+) mu(-) decay of a light vector gauge boson, also known as dark photon, in the e(+) e(-) -> mu(+) mu(-) gamma(ISR) process by means of the Initial State Radiation (ISR) method. We used 1.93fb(-1) of data collected by the KLOE experiment at the DA Phi NE phi-factory. No structures have been observed over the irreducible mu(+) mu(-) background. A 90% CL limit on the ratio epsilon(2)= alpha'/alpha between the dark coupling constant and the fine structure constant of 3 x 10(-6)-2 x 10(-7) has been set in the dark photon mass region between 519 MeV and 973 MeV. This new limit has been combined with the published result obtained investigating the hypothesis of the dark photon decaying into hadrons in e(+) e(-) -> pi(+) pi(-) gamma(ISR) events. The combined 90% CL limit increases the sensitivity especially in the rho-omega interference region and excludes epsilon(2) greater than (13 - 2) x 10(-7). For dark photon masses greater than 600 MeV the combined limit is lower than 8 x 10(-7) resulting more stringent than present constraints from other experiments.
  •  
39.
  • Anastasi, A., et al. (författare)
  • Measurement of the charge asymmetry for the K-S -> pi e nu decay and test of CPT symmetry with the KLOE detector
  • 2018
  • Ingår i: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :9
  • Tidskriftsartikel (refereegranskat)abstract
    • Using 1.63 fb(-1) of integrated luminosity collected by the KLOE experiment about 7 x 10(4) K-S -> pi(+/-)e(-/+)nu decays have been reconstructed. The measured value of the charge asymmetry for this decay is A(S) = (-4.9 +/- 5.7(stat) +/- 2.6(syst)) x 10(-3) which is almost twice more precise than the previous KLOE result. The combination of these two measurements gives A(S) = (3.8 +/- 5.0(stat) +/- 2.6(syst)) x 10(-3) and, together with the asymmetry of the K-L semileptonic decay, provides significant tests of the CPT symmetry. The obtained results are in agreement with CPT invariance.
  •  
40.
  • Archilli, F., et al. (författare)
  • Search for a vector gauge boson in phi meson decays with the KLOE detector KLOE-2 Collaboration
  • 2012
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 706:4-5, s. 251-255
  • Tidskriftsartikel (refereegranskat)abstract
    • The existence of a light dark force mediator has been tested with the KLOE detector at DA Phi NE. This particle, called U. is searched for using the decay chain phi -> eta U, eta -> pi(+)pi(-)pi(0), U -> e(+)e(-). No evidence is found in 1.5 fb(-1) of data. The resulting exclusion plot covers the mass range 5 < M-U < 470 MeV, setting an upper limit on the ratio between the U boson coupling constant and the One structure constant, alpha'/alpha, of <= 2 x 10(-5) at 90% C.L. for 50 < M-U < 420 MeV.
  •  
41.
  • Babusci, D., et al. (författare)
  • A new limit on the CP violating decay K-S -> 3 pi(0) with the KLOE experiment
  • 2013
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 723:1-3, s. 54-60
  • Tidskriftsartikel (refereegranskat)abstract
    • We have carried out a new direct search for the CP violating decay K-S -> 3 pi(0) with 1.7 fb(-1) of e(+)e(-) collisions collected by the KLOE detector at the Phi-factory DA Phi NE. We have searched for this decay in a sample of about 5.9 x 10(8) KSKL events tagging the K-S by means of the K-L interaction in the calorimeter and requiring six prompt photons. With respect to our previous search, the analysis has been improved by increasing of a factor four the tagged sample and by a more effective background rejection of fake K-S tags and spurious clusters. We find no candidates in data and simulated background samples, while we expect 0.12 standard model events. Normalizing to the number of K-S -> 2 pi(0) events in the same sample, we set the upper limit on BR(K-S -> 3 pi(0)) <= 2.6 x 10(-8) at 90% C.L., five times lower than the previous limit. We also set the upper limit on the eta(000) parameter, vertical bar eta(000)vertical bar <= 0.0088 at 90% C.L., improving by a factor two the latest direct measurement. (c) 2013 Elsevier B.V. All rights reserved.
  •  
42.
  • Babusci, D., et al. (författare)
  • Measurement of the branching fraction for the decay K-S -> pi mu nu with the KLOE detector
  • 2020
  • Ingår i: Physics Letters B. - : ELSEVIER. - 0370-2693 .- 1873-2445. ; 804
  • Tidskriftsartikel (refereegranskat)abstract
    • Based on a sample of 300 million K-S mesons produced in phi -> KLKS decays recorded by the KLOE experiment at the DA Phi NE e(+)e(-) collider we have measured the branching fraction for the decay K-S -> pi mu nu. The K-S mesons are identified by the interaction of K-L mesons in the detector. The K-S -> pi mu nu decays are selected by a boosted decision tree built with kinematic variables and by a time-of-flight measurement. Signal efficiencies are evaluated with data control samples of K-L -> pi mu nu decays. A fit to the reconstructed muon mass distribution finds 7223 +/- 180 signal events. Normalising to the K-S -> pi(+)pi(-) decay events the result for the branching fraction is B(K-S -> pi mu nu) = (4.56 +/- 0.11(stat) +/- 0.17(syst)) x 10(-4). It is the first measurement of this decay mode and the result allows an independent determination of vertical bar V-us vertical bar and a test of the lepton-flavour universality. (c) 2020 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  •  
43.
  • Babusci, D., et al. (författare)
  • Measurement of Γ(η→π+π-γ)/Γ(η→π+π-π0) with the KLOE detector
  • 2013
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 718:3, s. 910-914
  • Tidskriftsartikel (refereegranskat)abstract
    • The ratio Rη=Γ(η→π+π-γ)/Γ(η→π+π-π0) has been measured by analysing 22 million φ→ηγ decays collected by the KLOE experiment at DAΦNE, corresponding to an integrated luminosity of 558 pb-1. The η→π+π-γ proceeds both via the ρ resonant contribution, and possibly a non-resonant direct term, connected to the box anomaly. Our result, Rη=0.1856±0.0005stat±0.0028syst, points out a sizable contribution of the direct term to the total width. The di-pion invariant mass for the η→π+π-γ decay could be described in a model-independent approach in terms of a single free parameter, α. The determined value of the parameter α is α=(1.32±0.08stat-0.09syst+0.10±0.02theo) GeV-2.
  •  
44.
  • Babusci, D., et al. (författare)
  • Precision tests of quantum mechanics and CPT symmetry with entangled neutral kaons at KLOE
  • 2022
  • Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479.
  • Tidskriftsartikel (refereegranskat)abstract
    • The quantum interference between the decays of entangled neutral kaons is studied in the process phi -> KSKL -> pi(+)pi(-)pi(+)pi(-), which exhibits the characteristic Einstein-Podolsky-Rosen correlations that prevent both kaons to decay into pi(+)pi(-) at the same time. This constitutes a very powerful tool for testing at the utmost precision the quantum coherence of the entangled kaon pair state, and to search for tiny decoherence and CPT violation effects, which may be justified in a quantum gravity framework. The analysed data sample was collected with the KLOE detector at DA Phi NE, the Frascati phi-factory, and corresponds to an integrated luminosity of about 1.7 fb(-1), i.e. to about 1.7 x 10(9) phi -> KSKL decays produced. From the fit of the observed Delta t distribution, being Delta t the difference of the kaon decay times, the decoherence and CPT violation parameters of various phenomenological models are measured with a largely improved accuracy with respect to previous analyses. The results are consistent with no deviation from quantum mechanics and CPT symmetry, while for some parameters the precision reaches the interesting level at which - in the most optimistic scenarios - quantum gravity effects might show up. They provide the most stringent limits up to date on the considered models.
  •  
45.
  • Babusci, D., et al. (författare)
  • Study of the Dalitz decay phi -> eta e(+)e(-) with the KLOE detector
  • 2015
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 742, s. 1-6
  • Tidskriftsartikel (refereegranskat)abstract
    • We have studied the vector to pseudoscalar conversion decay phi -> eta e(+)e(-), with.. eta -> pi(0)pi(0)pi(0), with the KLOE detector at DA phi NE. The data set of 1.7 fb(-1) of e(+)e(-) collisions at root s similar to M-phi contains a clear conversion decay signal of similar to 31,000 events from which we measured a value of BR(phi -> eta e(+)e-) = (1.075 +/- 0.007 +/- 0.038) x 10(-4). The same sample is used to determine the transition form factor by a fit to the e(+)e(-) invariant mass spectrum, obtaining b(phi eta)=( 1.28 +/- 0.10(-0.08)(+0.09)) GeV-2, that improves by a factor of five the precision of the previous measurement and is in good agreement with VMD expectations.
  •  
46.
  • Babusci, D., et al. (författare)
  • Upper limit on the eta -> pi(+)pi(-) branching fraction with the KLOE experiment
  • 2020
  • Ingår i: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :10
  • Tidskriftsartikel (refereegranskat)abstract
    • Based on an integrated luminosity of 1.61 fb(-1)e(+)e(-) collision data collected with the KLOE detector at DA Phi NE, the Frascati phi -factory, a search for the P- and CP-violating decay eta -> pi (+)pi (-) has been performed. Radiative phi -> eta gamma decay is exploited to access the eta mesons. No signal is observed in the pi (+)pi (-) invariant mass spectrum, and the upper limit on the branching fraction at 90% confidence level is determined to be B(eta -> pi (+)pi (-)) < 4.9 x 10(-6), which is approximately three times smaller than the previous KLOE result. From the combination of these two measurements we get B( -> pi (+)pi (-)) < 4.4 x 10(-6) at 90% confidence level.
  •  
47.
  • Babuscih, D., et al. (författare)
  • Measurement of the absolute branching ratio of the K+ -> pi(+) pi(-) pi(+) (gamma) decay with the KLOE detector
  • 2014
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 738, s. 128-133
  • Tidskriftsartikel (refereegranskat)abstract
    • The absolute branching ratio of the K+ -> pi(+) pi(-) pi(+) (gamma) decay, inclusive of final-state radiation, has been measured using similar to 17 million tagged K+ mesons collected with the KLOE detector at DA Phi NE, the Frascati phi-factory. The result is: BR(K+ -> pi(+) pi(-) pi(+) (gamma)) = 0.05565 +/- 0.00031(stat) +/- 0.00025(syst) a factor similar or equal to 5 more precise with respect to the previous result. This work completes the program of precision measurements of the dominant kaon branching ratios at KLOE.
  •  
48.
  • Bazilevskaya, G. A., et al. (författare)
  • Solar energetic particle events in 2006-2012 in the PAMELA experiment data
  • 2013
  • Ingår i: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 409:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA magnetic spectrometer launched in June 2006 has observed the last strong energetic solar particle event of the 23rd solar cycle in December 2006. Subsequent long minimum of solar activity and weak development of the 24th solar cycle led to a deficit in the solar energetic particle events on the Earth orbit. As a result, only few events with protons accelerated above 100 MeV occurred in 2010-2012. The paper gives the preliminary results on energetic solar particles in the beginning of the 24th solar circle as measured with the PAMELA instrument.
  •  
49.
  • Beyer, J., et al. (författare)
  • Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer
  • 2013
  • Ingår i: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 24:4, s. 878-888
  • Forskningsöversikt (refereegranskat)abstract
    • In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497-513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, similar to 50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.
  •  
50.
  • Boezio, M., et al. (författare)
  • The PAMELA space mission for antimatter and dark matter searches in space
  • 2012
  • Ingår i: Hyperfine Interactions. - : Springer Science and Business Media LLC. - 0304-3843 .- 1572-9540. ; 213:1-3, s. 147-158
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA satellite-borne experiment has presented new results on cosmic-ray antiparticles that can be interpreted in terms of DM annihilation or pulsar contribution. The instrument was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The combination of a permanent magnet silicon strip spectrometer and a silicon-tungsten imaging calorimeter allows precision studies of the charged cosmic radiation to be conducted over a wide energy range with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectrum in order to search for exotic sources. PAMELA is also searching for primordial antinuclei (anti-helium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. This talk illustrates the most recent scientific results obtained by the PAMELA experiment.
  •  
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