| 1. |
- Delfin, C, et al.
(författare)
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Influence of the medium length on high-order harmonic generation
- 1999
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Ingår i: Journal of Physics B: Atomic, Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 32:22, s. 5397-5409
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Tidskriftsartikel (refereegranskat)abstract
- We study high-order harmonic generation using a 110 fs Ti:sapphire laser loosely focused into a variable-length gas cell filled with neon or argon at 5 mbar pressure. The harmonic intensity is recorded as a function of the medium length, varying between 2 and 21 mm. Several cases are examined, the 17th and the 29th harmonic in argon, and the 29th and 51st harmonic in neon, at the same intensity 4 x 10(14) W cm(-2). We find that the length which maximizes the harmonic yield varies from 10 mm to more than 20 mm. We discuss the different effects affecting the photon yield of the high-order harmonics.
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| 2. |
- Altucci, C, et al.
(författare)
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Frequency-resolved time-gated high-order harmonics
- 1998
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 58:5, s. 3934-3941
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Tidskriftsartikel (refereegranskat)abstract
- We report measurements of high-order harmonic spectra obtained with a 800-nm 150-fs loser pulse with a time-varying degree of ellipticity. The modulation of the polarization in time is achieved by using birefringent optics and self-phase modulation in a glass plate. We can create one or two temporal gates of a few femtoseconds width, during which the polarization is linear and harmonic emission is efficient. The harmonic spectra observed experimentally demonstrate that harmonics generated with linear polarization are frequency chirped. The values measured experimentally are consistent with theoretical predictions based on the strong field approximation. [S1050-2947(98)05511-5].
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| 3. |
- Gahn, C, et al.
(författare)
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Generating positrons with femtosecond-laser pulses
- 2000
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 77:17, s. 2662-2664
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Tidskriftsartikel (refereegranskat)abstract
- Utilizing a femtosecond table-top laser system, we have succeeded in converting via electron acceleration in a plasma channel, low-energy photons into antiparticles, namely positrons. The average intensity of this source of positrons is estimated to be equivalent to 2x10(8) Bq and it exhibits a very favorable scaling for higher laser intensities. The advent of positron production utilizing femtosecond laser pulses may be the forerunner to a table-top positron source appropriate for applications in material science, and fundamental physics research like positronium spectroscopy. (C) 2000 American Institute of Physics. [S0003-6951(00)00143-1].
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| 4. |
- Gahn, C, et al.
(författare)
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Generation of MeV electrons and positrons with femtosecond pulses from a table-top laser system
- 2002
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Ingår i: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 9:3, s. 987-999
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Tidskriftsartikel (refereegranskat)abstract
- In experiments, the feasibility was demonstrated of generating multi-MeV electrons in a form of a collimated beam utilizing a table-top laser system delivering 200 fs pulses with P-L=1.2 TW and 10 Hz capability. The method uses the process of relativistic self-channeling in a high-density gas jet producing electron densities in the range of 3x10(19)-6x10(20) cm(-3). In a thorough investigation, angularly resolved and absolutely calibrated electron spectra were measured and their dependence on the plasma density, laser intensity, and gas medium was studied. For the optimum electron density of n(e)=2x10(20) cm(-3) the effective temperature of the electron energy distribution and the channel length exhibit a maximum of 5 MeV and 400 mum respectively. The laser-energy to-MeV-electron efficiency is estimated to be 5%. In a second step, utilizing the multi-MeV electron beam anti-particles, namely positrons, were successfully generated in a 2 mm Pb converter. The average intensity of this new source of positrons is estimated to be equivalent to a radioactivity of 2x10(8) Bq and it exhibits a very favorable scaling for higher laser intensities. (C) 2002 American Institute of Physics.
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| 5. |
- Lynga, C, et al.
(författare)
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Temporal coherence of high-order harmonics
- 1999
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 60:6, s. 4823-4830
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Tidskriftsartikel (refereegranskat)abstract
- Systematic studies of the temporal coherence properties of high-order harmonic radiation are presented. These complement our previous investigations [Bellini et at, Phys. Rev. Lett. 81, 297 (1998)], where we showed the separation of the far-field pattern of high-order harmonics into two distinct spatial regions with different coherence times. Here we show how the coherence time of the inner and outer regions changes as a function of the harmonic order, the laser intensity, and the focusing conditions. Good agreement with the predictions of the semiclassical model of harmonic generation is obtained. [S1050-2947(99)10312-3].
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| 6. |
- Collantes, Edward Ryan A., et al.
(författare)
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EFEMP1 rare variants cause familial juvenile-onset open-angle glaucoma
- 2022
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Ingår i: Human Mutation. - : John Wiley & Sons. - 1059-7794 .- 1098-1004. ; 43:2, s. 240-252
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Tidskriftsartikel (refereegranskat)abstract
- Juvenile open-angle glaucoma (JOAG) is a severe type of glaucoma with onset before age 40 and dominant inheritance. Using exome sequencing we identified 3 independent families from the Philippines with novel EFEMP1 variants (c.238A>T, p.Asn80Tyr; c.1480T>C, p.Ter494Glnext*29; and c.1429C>T, p.Arg477Cys) co-segregating with disease. Affected variant carriers (N = 34) exhibited severe disease with average age of onset of 16 years and with 76% developing blindness. To investigate functional effects, we transfected COS7 cells with vectors expressing the three novel EFEMP1 variants and showed that all three variants found in JOAG patients caused significant intracellular protein aggregation and retention compared to wild type and also compared to EFEMP1 variants associated with other ocular phenotypes including an early-onset form of macular degeneration, Malattia Leventinese/Doyne's Honeycomb retinal dystrophy. These results suggest that rare EFEMP1 coding variants can cause JOAG through a mechanism involving protein aggregation and retention, and that the extent of intracellular retention correlates with disease phenotype. This is the first report of EFEMP1 variants causing JOAG, expanding the EFEMP1 disease spectrum. Our results suggest that EFEMP1 mutations appear to be a relatively common cause of JOAG in Filipino families, an ethnically diverse population.
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| 7. |
- Delfin, Carl, et al.
(författare)
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A Federated Database for Obesity Research : An IMI-SOPHIA Study
- 2024
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Ingår i: Life. - 0024-3019. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.
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| 8. |
- Delfin, C, et al.
(författare)
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Influence of laser pulse duration on relativistic channels
- 2002
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Ingår i: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 9:3, s. 937-940
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Tidskriftsartikel (refereegranskat)abstract
- A high-power (10 TW) laser is employed to generate relativistic channels in an underdense plasma. The lengths of the channels are measured by imaging the Thomson-scattered light, and the gas densities are determined through the forward Raman scattered light. The laser-pulse parameters are varied and their impact on the channel formation is studied. It is found that increasing the laser pulse duration in many cases produces longer channels, even as this implies reducing the laser peak power. A theoretical discussion is presented, proposing an explanation of the experimental results. (C) 2002 American Institute of Physics.
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| 9. |
- Descamps, D, et al.
(författare)
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Two- and three-photon ionization of rare gases using femtosecond harmonic pulses generated in a gas medium
- 2001
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 64:3
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Tidskriftsartikel (refereegranskat)abstract
- The fifth harmonic of a 60-fs 10-Hz terawatt titanium:sapphire laser generated in Xe gas is used to ionize Xe and Kr atoms by nonresonant two-photon absorption and At atoms through a quasiresonant three-photon process. At relatively low harmonic yields, the variation of the number of Kr and Xe ions with the number of harmonic photons is quadratic. At high harmonic yields, it deviates from a quadratic behavior, which we attribute to the influence of ionization in the harmonic process distorting the harmonic wave front. The two-photon ionization cross sections in Xe and Kr at 160 nm are found to be comparable.
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| 10. |
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| 11. |
- Sjögren, Anders, et al.
(författare)
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Relativistic channel formation with different pulse durations
- 2002
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Ingår i: AIP Conference Proceedings. - : AIP. - 1551-7616 .- 0094-243X. ; 611, s. 119-125
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Konferensbidrag (refereegranskat)abstract
- Relativistic channels are generated in an under-dense plasma by means of subpicosecond laser pulses. The channel extension is characterized via the Thomson-scattered light and the impact of the laser pulse duration and chirp are studied. It is shown that, under certain conditions, the channel extends further when the pulse duration is increased. This is in contrast to many earlier reports, where the channel grows with increasing laser power. Some theoretical arguments are presented to support the experimental findings. The number of electrons, accelerated in the forward direction, and their energies are assessed. In some cases, it is found that the channel divides and the fragments extend in different directions. This raises the question if, and how, the channel formation can be externally manipulated
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