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- Baldoni, R., et al.
(författare)
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An embedded middleware platform for pervasive and immersive environments for-all
- 2009
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Ingår i: 2009 6th IEEE Annual Communications Society Conference on Sensor, Mesh and Ad Hoc Communications and Networks Workshops, SECON Workshops 2009. - : IEEE. - 9781424439386 ; , s. 161-163
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Konferensbidrag (refereegranskat)abstract
- Embedded systems are specialized computers used in larger systems or machines to control equipments such as automobiles, home appliances, communication, control and office machines. Such pervasivity is particularly evident in immersive realities, i.e., scenarios in which invisible embedded systems need to continuously interact with human users, in order to provide continuous sensed information and to react to service requests from the users themselves. The SM4All project investigates an innovative middleware platform for inter-working of smart embedded services in immersive and person-centric environments, through the use of composability and semantic techniques for dynamic service reconfiguration. This is applied to the challenging scenario of private houses and home-care assistance in presence of users with different abilities and needs (e.g., young, able-bodied, aged and disabled). This paper presentes a brief overview of the SM4All system architecture.
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- Merlano, MC, et al.
(författare)
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Cytokine Profiling of End Stage Cancer Patients Treated with Immunotherapy
- 2021
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Ingår i: Vaccines. - : MDPI AG. - 2076-393X. ; 9:3
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Tidskriftsartikel (refereegranskat)abstract
- Published data suggest that immunotherapy plays a role even in patients with very advanced tumours. We investigated the immune profile of end-stage cancer patients treated with immunotherapy to identify changes induced by treatment. Breast, colon, renal and prostate cancer patients were eligible. Treatment consisted of metronomic cyclophosphamide, low-dose interleukin-2 (IL-2) and a single radiation shot. A panel of 16 cytokines was assessed using automated ELISA before treatment (T0), after radiation (RT; T1), at cycle 2 (T2) and at disease progression (TPD). Receiving operating characteristic (ROC) analysis was used to identify cytokine cut-off related to overall survival (OS). Principal component analysis (PCA) was used to identify the immune profile correlating better with OS and progression-free survival. Twenty-three patients were enrolled. High IL-2, low IL-8 and CCL-2 correlated with OS. The PCA identified a cluster of patients, with high IL-2, IL-12 and IFN-γ levels at T0 having longer PFS and OS. In all cohorts, IL-2 and IL-5 increased from T0 to T2; a higher CCL-4 level compared to T2 and a higher IL-8 level compared to T0 were found at TPD. The progressive increase of the IL-10 level during treatment negatively correlated with OS. Our data suggested that baseline cytokine levels may predict patients’ outcome and that the treatment may affect their kinetic even in end-stage patients. Cytokine profiling of end-stage patients might offer a tool for medical decisions (EUDRACT: 2016-000578-39).
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