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- Ringden, O, et al.
(författare)
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The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation
- 2009
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 113:13, s. 3110-3118
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Tidskriftsartikel (refereegranskat)abstract
- Do some patients benefit from an unrelated donor (URD) transplant because of a stronger graft-versus-leukemia (GVL) effect? We analyzed 4099 patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML) undergoing a myeloablative allogeneic hematopoietic cell transplantation (HCT) from an URD (8/8 human leukocyte antigen [HLA]–matched, n = 941) or HLA-identical sibling donor (n = 3158) between 1995 and 2004 reported to the CIBMTR. In the Cox regression model, acute and chronic GVHD were added as time-dependent variables. In multivariate analysis, URD transplant recipients had a higher risk for transplantation-related mortality (TRM; relative risk [RR], 2.76; P < .001) and relapse (RR, 1.50; P < .002) in patients with AML, but not ALL or CML. Chronic GVHD was associated with a lower relapse risk in all diagnoses. Leukemia-free survival (LFS) was decreased in patients with AML without acute GVHD receiving a URD transplant (RR, 2.02; P < .001) but was comparable to those receiving HLA-identical sibling transplants in patients with ALL and CML. In patients without GVHD, multivariate analysis showed similar risk of relapse but decreased LFS for URD transplants for all 3 diagnoses. In conclusion, risk of relapse was the same (ALL, CML) or worse (AML) in URD transplant recipients compared with HLA-identical sibling transplant recipients, suggesting a similar GVL effect.
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- Di Bartolomeo, G., et al.
(författare)
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Promises and partner-switch
- 2023
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Ingår i: Journal of the Economic Science Association-Jesa. - : Springer Science and Business Media LLC. - 2199-6776 .- 2199-6784. ; 9, s. 77-89
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Tidskriftsartikel (refereegranskat)abstract
- Building on a partner-switching mechanism, we experimentally test two theories that posit different reasons why promises breed trust and cooperation. The expectation-based explanation (EBE) operates via belief-dependent guilt aversion, while the commitment-based explanation (CBE) suggests that promises offer commitment power via a (belief-independent) preference to keep one's word. Previous research performed a similar test, which we argue should be interpreted as concerning informal agreements rather than (unilateral) promises.
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- Di Bartolomeo, G., et al.
(författare)
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Promises, expectations & causation
- 2019
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Ingår i: Games and Economic Behavior. - : Elsevier BV. - 0899-8256. ; 113, s. 137-146
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Tidskriftsartikel (refereegranskat)abstract
- Why do people keep their promises? Vanberg (2008) and Ederer and Stremitzer (2017) provide causal evidence in favor of, respectively, an intrinsic preference for keeping one's word and Charness and Dufwenberg's (2006) expectations-based account based on guilt aversion. The overall picture is incomplete though, as no study disentangles effects in a design that provides exogenous variation of both (the key features of) promises and beliefs. We report evidence from an experimental design that does so. (C) 2018 Elsevier Inc. All rights reserved.
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- Di Bartolomeo, G., et al.
(författare)
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Promises or agreements? Moral commitments in bilateral communication
- 2023
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Ingår i: Economics Letters. - : Elsevier BV. - 0165-1765. ; 222
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Tidskriftsartikel (refereegranskat)abstract
- In a game with pre-play bilateral communication, messages may trigger moral incentives to honor promises or agreements. We hypothesize that individuals' inclination to keep a promise is highest if the counterpart requited the promise. We interpret this as an inclination to honor informal agreements. We report supporting results from an experiment.
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- Di Bartolomeo, G., et al.
(författare)
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The sound of silence: A license to be selfish
- 2019
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Ingår i: Economics Letters. - : Elsevier BV. - 0165-1765. ; 182, s. 68-70
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Tidskriftsartikel (refereegranskat)abstract
- We theoretically formulate the idea that if a person stays silent in a situation where a promise could have been made, then he or she will subsequently act as if having a license to be selfish. We then report results from an experimental test that provides some support.
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- Di Bartolomeo, S, et al.
(författare)
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Cross-sectional investigation of HEMS activities in Europe: a feasibility study
- 2014
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Ingår i: TheScientificWorldJournal. - : Hindawi Limited. - 1537-744X. ; 2014, s. 201570-
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Tidskriftsartikel (refereegranskat)abstract
- Objectives.To gather information on helicopter emergency medical services (HEMSs) activities across Europe.Methods.Cross-sectional data-collection on daily (15 November 2013) activities of a sample of European HEMSs. A web-based questionnaire with both open and closed questions was used, developed by experts of the European Prehospital Research Alliance (EUPHOREA).Results.We invited 143 bases from 11 countries; 85 (60%) reported base characteristics only and 73 (51%) sample-day data too. The variety of base characteristics was enormous; that is, the target population ranged from 94.000 to 4.500.000. Of 158 requested primary missions, 62 (0.82 per base) resulted in landing. Cardiac aetiology (36%) and trauma (36%) prevailed, mostly of life-threatening severity (43%, 0.64 per mission). Had HEMS been not dispatched, patients would have been attended by another physician in 67% of cases, by paramedics in 24%, and by nurses in 9%. On-board physicians estimated to have caused a major decrease of death risk in 47% of missions, possible decrease in 22%, minor benefit in 17%, no benefit in 11%, and damage in 3%. Earlier treatment and faster transport to hospital were the main reasons for benefit. The most frequent therapeutic procedure was drug administration (78% of missions); endotracheal intubation occurred in 25% of missions and was an option hardly offered by ground crews.Conclusions.The study proved feasible, establishing an embryonic network of European HEMS. The participation rate was low and limits the generalizability of the results. Fortunately, because of its cross-sectional characteristics and the handy availability of the web platform, the study is easily repeatable with an enhanced network.
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