| 1. |
- Bao, Erik L, et al.
(författare)
-
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
- 2020
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 586:7831, s. 769-775
-
Tidskriftsartikel (refereegranskat)abstract
- Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci have been identified, and the underlying biological mechanisms that lead to the acquisition of MPNs remain unclear. Here, by conducting a large-scale genome-wide association study (3,797 cases and 1,152,977 controls), we identify 17 MPN risk loci (P < 5.0 × 10-8), 7 of which have not been previously reported. We find that there is a shared genetic architecture between MPN risk and several haematopoietic traits from distinct lineages; that there is an enrichment for MPN risk variants within accessible chromatin of HSCs; and that increased MPN risk is associated with longer telomere length in leukocytes and other clonal haematopoietic states-collectively suggesting that MPN risk is associated with the function and self-renewal of HSCs. We use gene mapping to identify modulators of HSC biology linked to MPN risk, and show through targeted variant-to-function assays that CHEK2 and GFI1B have roles in altering the function of HSCs to confer disease risk. Overall, our results reveal a previously unappreciated mechanism for inherited MPN risk through the modulation of HSC function.
|
|
| 2. |
- Satizabal, Claudia L., et al.
(författare)
-
Genetic architecture of subcortical brain structures in 38,851 individuals
- 2019
-
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
-
Tidskriftsartikel (refereegranskat)abstract
- Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
|
|
| 3. |
- Belov, Vladimir, et al.
(författare)
-
Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
- 2024
-
Ingår i: Scientific Reports. - : NATURE PORTFOLIO. - 2045-2322. ; 14:1
-
Tidskriftsartikel (refereegranskat)abstract
- Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (N = 5365) to provide a generalizable ML classification benchmark of major depressive disorder (MDD) using shallow linear and non-linear models. Leveraging brain measures from standardized ENIGMA analysis pipelines in FreeSurfer, we were able to classify MDD versus healthy controls (HC) with a balanced accuracy of around 62%. But after harmonizing the data, e.g., using ComBat, the balanced accuracy dropped to approximately 52%. Accuracy results close to random chance levels were also observed in stratified groups according to age of onset, antidepressant use, number of episodes and sex. Future studies incorporating higher dimensional brain imaging/phenotype features, and/or using more advanced machine and deep learning methods may yield more encouraging prospects.
|
|
| 4. |
- Dima, Danai, et al.
(författare)
-
Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
- 2022
-
Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
-
Tidskriftsartikel (refereegranskat)abstract
- Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
|
|
| 5. |
- Frangou, Sophia, et al.
(författare)
-
Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
-
Tidskriftsartikel (refereegranskat)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
|
|
| 6. |
- Gould, Rebecca, et al.
(författare)
-
Acceptance and Commitment Therapy for people living with motor neuron disease : an uncontrolled feasibility study
- 2023
-
Ingår i: Pilot and Feasibility Studies. - : Springer Nature. - 2055-5784. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Motor neuron disease (MND) is a fatal, progressive neurodegenerative disease that causes progressive weakening and wasting of limb, bulbar, thoracic and abdominal muscles. Clear evidence-based guidance on how psychological distress should be managed in people living with MND (plwMND) is lacking. Acceptance and Commitment Therapy (ACT) is a form of psychological therapy that may be particularly suitable for this population. However, to the authors' knowledge, no study to date has evaluated ACT for plwMND. Consequently, the primary aim of this uncontrolled feasibility study was to examine the feasibility and acceptability of ACT for improving the psychological health of plwMND.Methods: PlwMND aged >= 18 years were recruited from 10 UK MND Care Centres/Clinics. Participants received up to 8 one-to-one ACT sessions, developed specifically for plwMND, plus usual care. Co-primary feasibility and acceptability outcomes were uptake (>= 80% of the target sample [N = 28] recruited) and initial engagement with the intervention (>= 70% completing >= 2 sessions). Secondary outcomes included measures of quality of life, anxiety, depression, disease-related functioning, health status and psychological flexibility in plwMND and quality of life and burden in caregivers. Outcomes were assessed at baseline and 6 months.Results: Both a priori indicators of success were met: 29 plwMND (104%) were recruited and 76% (22/29) attended >= 2 sessions. Attrition at 6-months was higher than anticipated (8/29, 28%), but only two dropouts were due to lack of acceptability of the intervention. Acceptability was further supported by good satisfaction with therapy and session attendance. Data were possibly suggestive of small improvements in anxiety and psychological quality of life from baseline to 6 months in plwMND, despite a small but expected deterioration in disease-related functioning and health status.Conclusions: There was good evidence of acceptability and feasibility. Limitations included the lack of a control group and small sample size, which complicate interpretation of findings. A fully powered RCT to evaluate the clinical and cost-effectiveness of ACT for plwMND is underway.
|
|
| 7. |
- Hibar, Derrek P., et al.
(författare)
-
Novel genetic loci associated with hippocampal volume
- 2017
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
|
|
| 8. |
- Sturm, Ulrike, et al.
(författare)
-
Defining principles for mobile apps and platforms development in citizen science
- 2017
-
Ingår i: Research Ideas and Outcomes. - : Pensoft Publishers. - 2367-7163. ; :3
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Mobile apps and web-based platforms are increasingly used in citizen science projects. While extensive research has been done in multiple areas of studies, from Human-Computer Interaction to public engagement in science, we are not aware of a collection of recommendations specific for citizen science that provides support and advice for planning, design and data management of mobile apps and platforms that will assist learning from best practice and successful implementations. In two workshops, citizen science practitioners with experience in mobile application and web-platform development and implementation came together to analyse, discuss and define recommendations for the initiators of technology based citizen science projects. Many of the recommendations produced during the two workshops are applicable to non-mobile citizen science project. Therefore, we propose to closely connect the results presented here with ECSA’s Ten Principles of Citizen Science.
|
|
| 9. |
- Thompson, Paul M., et al.
(författare)
-
The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
-
Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
-
Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
|
|
| 10. |
- Wierenga, Lara M., et al.
(författare)
-
Greater male than female variability in regional brain structure across the lifespan
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 470-499
-
Tidskriftsartikel (refereegranskat)abstract
- For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
|
|
| 11. |
- Baigent, Colin, et al.
(författare)
-
The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection) : a randomised placebo-controlled trial
- 2011
-
Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 377:9784, s. 2181-2192
-
Tidskriftsartikel (refereegranskat)abstract
- Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients. Methods This randomised double-blind trial included 9270 patients with chronic kidney disease (3023 on dialysis and 6247 not) with no known history of myocardial infarction or coronary revascularisation. Patients were randomly assigned to simvastatin 20 mg plus ezetimibe 10 mg daily versus matching placebo. The key prespecified outcome was first major atherosclerotic event (non-fatal myocardial infarction or coronary death, non-haemorrhagic stroke, or any arterial revascularisation procedure). All analyses were by intention to treat. This trial is registered at ClinicalTrials.gov, NCT00125593, and I SRCTN54137607. Findings 4650 patients were assigned to receive simvastatin plus ezetimibe and 4620 to placebo. Allocation to simvastatin plus ezetimibe yielded an average LDL cholesterol difference of 0.85 mmol/L (SE 0.02; with about two-thirds compliance) during a median follow-up of 4.9 years and produced a 17% proportional reduction in major atherosclerotic events (526 [11.3%] simvastatin plus ezetimibe vs 619 [13.4%] placebo; rate ratio [RR] 0.83, 95% CI 0.74-0.94; log-rank p=0.0021). Non-significantly fewer patients allocated to simvastatin plus ezetimibe had a non-fatal myocardial infarction or died from coronary heart disease (213 [4.6%] vs 230 [5.0%]; RR 0.92,95% CI 0.76-1.11; p=0.37) and there were significant reductions in non-haemorrhagic stroke (131 [2.8%] vs 174 [3.8%]; RR 0.75,95% CI 0.60-0.94; p=0.01) and arterial revascularisation procedures (284 [6.1%] vs 352 [7.6%]; RR 0.79, 95% CI 0.68-0.93; p=0.0036). After weighting for subgroup-specific reductions in LDL cholesterol, there was no good evidence that the proportional effects on major atherosclerotic events differed from the summary rate ratio in any subgroup examined, and, in particular, they were similar in patients on dialysis and those who were not. The excess risk of myopathy was only two per 10 000 patients per year of treatment with this combination (9 [0.2%] vs 5 [0.1%]). There was no evidence of excess risks of hepatitis (21 [0.5%] vs 18 [0.4%]), gallstones (106 [2.3%] vs 106 [2.3%]), or cancer (438 [9.4%] vs 439 [9.5%], p=0.89) and there was no significant excess of death from any non-vascular cause (668 [14.4%] vs 612 [13.2%], p=0.13). Interpretation Reduction of LDL cholesterol with simvastatin 20 mg plus ezetimibe 10 mg daily safely reduced the incidence of major atherosclerotic events in a wide range of patients with advanced chronic kidney disease.
|
|
| 12. |
- Baker, Paul A., et al.
(författare)
-
The emerging field of geogenomics : Constraining geological problems with genetic data
- 2014
-
Ingår i: Earth-Science Reviews. - : Elsevier BV. - 0012-8252 .- 1872-6828. ; 135, s. 38-47
-
Tidskriftsartikel (refereegranskat)abstract
- The development of a genomics-derived discipline within geology is timely, as a result of major advances in acquiring and processing geologically relevant genetic data. This paper articulates the emerging field of geogenomics, which involves the use of large-scale genetic data to constrain geological hypotheses. The paper introduces geogenomics and discusses how hypotheses can be addressed through collaboration between geologists and evolutionary biologists. As an example, geogenomic methods are applied to evaluate competing hypotheses regarding the timing of the Andean uplift, the closure of the Isthmus of Panama, the onset of trans-Amazon drainage, and Quaternary climate variation in the Neotropics.
|
|
| 13. |
- Behrendt, Christian-Alexander, et al.
(författare)
-
Editor's Choice - Recommendations for Registry Data Collection for Revascularisations of Acute Limb Ischaemia : A Delphi Consensus from the International Consortium of Vascular Registries
- 2019
-
Ingår i: European Journal of Vascular and Endovascular Surgery. - : W B SAUNDERS CO LTD. - 1078-5884 .- 1532-2165. ; 57:6, s. 816-821
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To develop a minimum core data set for evaluation of acute limb ischaemia (ALI) revascularisation treatment and outcomes that would enable collaboration among international registries. Methods: A modified Delphi approach was used to achieve consensus among international multidisciplinary vascular specialists and registry members of the International Consortium of Vascular Registries (ICVR). Variables identified in the literature or suggested by the expert panel, and variables, including definitions, currently used in 15 countries in the ICVR, were assessed to define both a minimum core and an optimum data set to register ALI treatment. Clinical relevance and practicability were both assessed, and consensus was defined as >= 80% agreement among participants. Results: Of 40 invited experts, 37 completed a preliminary survey and 31 completed the two subsequent Delphi rounds via internet exchange and face to face discussions. In total, 117 different items were generated from the various registry data forms, an extensive review of the literature, and additional suggestions from the experts, for potential inclusion in the data set. Ultimately, 35 items were recommended for inclusion in the minimum core data set, including 23 core items important for all registries, and an additional 12 more specific items for registries capable of capturing more detail. These 35 items supplement previous data elements recommended for registering chronic peripheral arterial occlusive disease treatment. Conclusion: A modified Delphi study allowed 37 international vascular registry experts to achieve a consensus recommendation for a minimum core and an optimum data set for registries covering patients who undergo ALI revascularisation. Continued global harmonisation of registry infrastructure and definition of items allows international comparisons and global quality improvement. Furthermore, it can help to define and monitor standards of care and enable international research collaboration.
|
|
| 14. |
- Bernal, Ximena E., et al.
(författare)
-
Empowering Latina scientists
- 2019
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 15. |
- Callaghan, Terry, et al.
(författare)
-
Multi-Decadal Changes in Tundra Environments and Ecosystems : Synthesis of the International Polar Year-Back to the Future Project (IPY-BTF)
- 2011
-
Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 40:6, s. 705-716
-
Tidskriftsartikel (refereegranskat)abstract
- Understanding the responses of tundra systemsto global change has global implications. Most tundraregions lack sustained environmental monitoring and oneof the only ways to document multi-decadal change is toresample historic research sites. The International PolarYear (IPY) provided a unique opportunity for such researchthrough the Back to the Future (BTF) project (IPY project#512). This article synthesizes the results from 13 paperswithin this Ambio Special Issue. Abiotic changes includeglacial recession in the Altai Mountains, Russia; increasedsnow depth and hardness, permafrost warming, andincreased growing season length in sub-arctic Sweden;drying of ponds in Greenland; increased nutrient availabilityin Alaskan tundra ponds, and warming at mostlocations studied. Biotic changes ranged from relativelyminor plant community change at two sites in Greenland tomoderate change in the Yukon, and to dramatic increasesin shrub and tree density on Herschel Island, and in subarcticSweden. The population of geese tripled at one sitein northeast Greenland where biomass in non-grazed plotsdoubled. A model parameterized using results from a BTFstudy forecasts substantial declines in all snowbeds andincreases in shrub tundra on Niwot Ridge, Colorado overthe next century. In general, results support and provideimproved capacities for validating experimental manipulation,remote sensing, and modeling studies.
|
|
| 16. |
- Chang, Dan, et al.
(författare)
-
The evolutionary and phylogeographic history of woolly mammoths : a comprehensive mitogenomic analysis
- 2017
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Near the end of the Pleistocene epoch, populations of the woolly mammoth (Mammuthus primigenius) were distributed across parts of three continents, from western Europe and northern Asia through Beringia to the Atlantic seaboard of North America. Nonetheless, questions about the connectivity and temporal continuity of mammoth populations and species remain unanswered. We use a combination of targeted enrichment and high-throughput sequencing to assemble and interpret a data set of 143 mammoth mitochondrial genomes, sampled from fossils recovered from across their Holarctic range. Our dataset includes 54 previously unpublished mitochondrial genomes and significantly increases the coverage of the Eurasian range of the species. The resulting global phylogeny confirms that the Late Pleistocene mammoth population comprised three distinct mitochondrial lineages that began to diverge ~1.0–2.0 million years ago (Ma). We also find that mammoth mitochondrial lineages were strongly geographically partitioned throughout the Pleistocene. In combination, our genetic results and the pattern of morphological variation in time and space suggest that male-mediated gene flow, rather than large-scale dispersals, was important in the Pleistocene evolutionary history of mammoths.
|
|
| 17. |
- Chye, Yann, et al.
(författare)
-
Subcortical surface morphometry in substance dependence : An ENIGMA addiction working group study
- 2020
-
Ingår i: Addiction Biology. - : WILEY. - 1355-6215 .- 1369-1600. ; 25:6
-
Tidskriftsartikel (refereegranskat)abstract
- While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.
|
|
| 18. |
- Cirulli, Elizabeth T., et al.
(författare)
-
A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
- 2019
-
Ingår i: Gastroenterology. - : W B SAUNDERS CO-ELSEVIER INC. - 0016-5085 .- 1528-0012. ; 156:6, s. 1707-1716
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.METHODS: We performed a genome-wide association study of 2048 individuals with DILI (cases) and 12,429 individuals without (controls). Our analysis included subjects of European (1806 cases and 10,397 controls), African American (133 cases and 1,314 controls), and Hispanic (109 cases and 718 controls) ancestry. We analyzed DNA from 113 Icelandic cases and 239,304 controls to validate our findings.RESULTS: We associated idiosyncratic DILI with rs2476601, a nonsynonymous polymorphism that encodes a substitution of tryptophan with arginine in the protein tyrosine phosphatase, nonreceptor type 22 gene (PTPN22) (odds ratio [OR] 1.44; 95% confidence interval [CI] 1.28-1.62; P = 1.2 x 10(-9) and replicated the finding in the validation set (OR 1.48; 95% CI 1.09-1.99; P =.01). The minor allele frequency showed the same effect size (OR > 1) among ethnic groups. The strongest association was with amoxicillin and clavulanate-associated DILI in persons of European ancestry (OR 1.62; 95% CI 1.32-1.98; P = 4.0 x 10(-6); allele frequency = 13.3%), but the polymorphism was associated with DILI of other causes (OR 1.37; 95% CI 1.21-1.56; P = 1.5 x 10(-6); allele frequency = 11.5%). Among amoxicillin-and clavulanate-associated cases of European ancestry, rs2476601 doubled the risk for DILI among those with the HLA risk alleles A* 02: 01 and DRB1* 15: 01.CONCLUSIONS: In a genome-wide association study, we identified rs2476601 in PTPN22 as a non-HLA variant that associates with risk of liver injury caused by multiple drugs and validated our finding in a separate cohort. This variant has been associated with increased risk of autoimmune diseases, providing support for the concept that alterations in immune regulation contribute to idiosyncratic DILI.
|
|
| 19. |
- Davies, Stuart J., et al.
(författare)
-
ForestGEO: Understanding forest diversity and dynamics through a global observatory network
- 2021
-
Ingår i: Biological Conservation. - : Elsevier BV. - 0006-3207. ; 253
-
Tidskriftsartikel (refereegranskat)abstract
- ForestGEO is a network of scientists and long-term forest dynamics plots (FDPs) spanning the Earth's major forest types. ForestGEO's mission is to advance understanding of the diversity and dynamics of forests and to strengthen global capacity for forest science research. ForestGEO is unique among forest plot networks in its large-scale plot dimensions, censusing of all stems ≥1 cm in diameter, inclusion of tropical, temperate and boreal forests, and investigation of additional biotic (e.g., arthropods) and abiotic (e.g., soils) drivers, which together provide a holistic view of forest functioning. The 71 FDPs in 27 countries include approximately 7.33 million living trees and about 12,000 species, representing 20% of the world's known tree diversity. With >1300 published papers, ForestGEO researchers have made significant contributions in two fundamental areas: species coexistence and diversity, and ecosystem functioning. Specifically, defining the major biotic and abiotic controls on the distribution and coexistence of species and functional types and on variation in species' demography has led to improved understanding of how the multiple dimensions of forest diversity are structured across space and time and how this diversity relates to the processes controlling the role of forests in the Earth system. Nevertheless, knowledge gaps remain that impede our ability to predict how forest diversity and function will respond to climate change and other stressors. Meeting these global research challenges requires major advances in standardizing taxonomy of tropical species, resolving the main drivers of forest dynamics, and integrating plot-based ground and remote sensing observations to scale up estimates of forest diversity and function, coupled with improved predictive models. However, they cannot be met without greater financial commitment to sustain the long-term research of ForestGEO and other forest plot networks, greatly expanded scientific capacity across the world's forested nations, and increased collaboration and integration among research networks and disciplines addressing forest science.
|
|
| 20. |
- Dick, Jan, et al.
(författare)
-
Testing the ecosystem service cascade framework and QUICKScan software tool in the context of land use planning in Glenlivet Estate Scotland
- 2017
-
Ingår i: International Journal of Biodiversity Science, Ecosystem Services & Management. - : Taylor & Francis. - 2151-3732 .- 2151-3740. ; 13:2, s. 12-25
-
Tidskriftsartikel (refereegranskat)abstract
- The concept of ecosystem services has been extensively studied in recent decades. Most studies have focused on describing the specific aspects such as production, spatial extent, valuation of services and the trade-off between services. Few studies however assess the practitioners? views on the frameworks, models or tools developed. In this paper, we report on a multi-stakeholder workshop where two tools were tested (i) the ecosystem service cascade framework was tested as a means to frame the issues and (ii) a participatory-spatial modelling method, QUICKScan, was tested as an aid to support discussion over natural resource management and planning in a multi-use landscape. A focused group discussion was utilised to determine stakeholders? views of the cascade framework and pre- and post-workshop questionnaires quantified the stakeholders? views of the QUICKScan method. The stakeholders identified both positive and negative aspects of both tools. The diversity of views expressed were associated with (i) the past experience of the individual with the issues discussed, (ii) the technical aspects of the tools i.e. the ability with GIS and (iii) the level of new shared knowledge they reported acquiring on the day which was related to their initial knowledge of the issue and area studied.
|
|
| 21. |
- Dick, Katherine J., et al.
(författare)
-
DNA methylation and body-mass index : a genome-wide analysis
- 2014
-
Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 383:9933, s. 1990-1998
-
Tidskriftsartikel (refereegranskat)abstract
- Background Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between several genetic variants and body-mass index (BMI) have been identified, little is known about epigenetic changes related to BMI. We undertook a genome-wide analysis of methylation at CpG sites in relation to BMI. Methods 479 individuals of European origin recruited by the Cardiogenics Consortium formed our discovery cohort. We typed their whole-blood DNA with the Infinium HumanMethylation450 array. After quality control, methylation levels were tested for association with BMI. Methylation sites showing an association with BMI at a false discovery rate q value of 0.05 or less were taken forward for replication in a cohort of 339 unrelated white patients of northern European origin from the MARTHA cohort. Sites that remained significant in this primary replication cohort were tested in a second replication cohort of 1789 white patients of European origin from the KORA cohort. We examined whether methylation levels at identified sites also showed an association with BMI in DNA from adipose tissue (n=635) and skin (n=395) obtained from white female individuals participating in the MuTHER study. Finally, we examined the association of methylation at BMI-associated sites with genetic variants and with gene expression. Findings 20 individuals from the discovery cohort were excluded from analyses after quality-control checks, leaving 459 participants. After adjustment for covariates, we identified an association (q value <= 0.05) between methylation at five probes across three different genes and BMI. The associations with three of these probes-cg22891070, cg27146050, and cg16672562, all of which are in intron 1 of HIF3A-were confirmed in both the primary and second replication cohorts. For every 0.1 increase in methylation beta value at cg22891070, BMI was 3.6% (95% CI 2.4-4.9) higher in the discovery cohort, 2.7% (1.2-4.2) higher in the primary replication cohort, and 0.8% (0.2-1.4) higher in the second replication cohort. For the MuTHER cohort, methylation at cg22891070 was associated with BMI in adipose tissue (p=1.72 x 10(-5)) but not in skin (p=0.882). We observed a significant inverse correlation (p=0.005) between methylation at cg22891070 and expression of one HIF3A gene-expression probe in adipose tissue. Two single nucleotide polymorphisms-rs8102595 and rs3826795-had independent associations with methylation at cg22891070 in all cohorts. However, these single nucleotide polymorphisms were not significantly associated with BMI. Interpretation Increased BMI in adults of European origin is associated with increased methylation at the HIF3A locus in blood cells and in adipose tissue. Our findings suggest that perturbation of hypoxia inducible transcription factor pathways could have an important role in the response to increased weight in people.
|
|
| 22. |
- Dick-Sagoe, Christopher, et al.
(författare)
-
Stakeholder perceptions on causes and effects of public project failures in Ghana
- 2023
-
Ingår i: Humanities and Social Sciences Communications. - : Springer Science and Business Media LLC. - 2662-9992. ; 10:1
-
Tidskriftsartikel (refereegranskat)abstract
- Factors responsible for the failure of most development projects are multifaceted. This study focused on unearthing the causes and effects of public project failure from the perspective of project stakeholders. Sixty stakeholders working on different public projects in the Greater Accra Region of Ghana completed a questionnaire. This study found that major causes of project failure were related to corruption, payment delays, procurement processes, planning, monitoring, bureaucracy, communication, and supervision. The perceived effects of project failure included revenue loss, discouraged investment, and unemployment. Project failure increased the initial cost of projects, impacted economic growth, led to the provision of substandard infrastructure and service relocation. Other effects of project failure were loss of capacity for public projects and emotional stress experienced by project stakeholders. The government of Ghana should adopt strategies to overcome corruption, bureaucracy, and unnecessary political influence. Finally, the government should cooperate with relevant stakeholders to implement measures geared towards improving the current system for procurement, supervision, monitoring, planning, and management practices.
|
|
| 23. |
|
|
| 24. |
- Garskaite, Edita, et al.
(författare)
-
The Accessibility of the Cell Wall in Scots Pine (Pinus sylvestris L.) Sapwood to Colloidal Fe3O4 Nanoparticles
- 2021
-
Ingår i: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 6:33, s. 21719-21729
-
Tidskriftsartikel (refereegranskat)abstract
- This work presents a rapid and facile way to access the cell wall of wood with magnetic nanoparticles (NPs), providing insights into a method of wood modification to prepare hybrid bio-based functional materials. Diffusion-driven infiltration into Scots pine (Pinus sylvestris L.) sapwood was achieved using colloidal Fe3O4 nanoparticles. Optical microscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, transmission electron microscopy, and X-ray powder diffraction analyses were used to detect and assess the accessibility of the cell wall to Fe3O4. The structural changes, filling of tracheids (cell lumina), and NP infiltration depth were further evaluated by performing X-ray microcomputed tomography analysis. Fourier transform infrared spectroscopy was used to assess the chemical changes in Scots pine induced by the interaction of the wood with the solvent. The thermal stability of Fe3O4-modified wood was studied by thermogravimetric analysis. Successful infiltration of the Fe3O4 NPs was confirmed by measuring the magnetic properties of cross-sectioned layers of the modified wood. The results indicate the feasibility of creating multiple functionalities that may lead to many future applications, including structural nanomaterials with desirable thermal properties, magnetic devices, and sensors.
|
|
| 25. |
- Groenewold, Nynke A., et al.
(författare)
-
Volume of subcortical brain regions in social anxiety disorder : mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
- 2023
-
Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 28:3, s. 1079-1089
-
Tidskriftsartikel (refereegranskat)abstract
- There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
- Jönsson, Mari, et al.
(författare)
-
Inequality persists in a large citizen science programme despite increased participation through ICT innovations
- 2024
-
Ingår i: Ambio: A Journal of Environment and Society. - 0044-7447 .- 1654-7209. ; 53:1, s. 126-137
-
Tidskriftsartikel (refereegranskat)abstract
- Biological recording is a prominent and widely practised form of citizen science, but few studies explore long-term demographic trends in participation and knowledge production. We studied long-term demographic trends of age and gender of participants reporting to a large online citizen science multi-taxon biodiversity platform (www.artportalen.se). Adoption by user communities and continually developing Information and Communications Technologies (ICTs) greatly increased the number of par- ticipants reporting data, but profound long-term imbalances in gender contribution across species groups persisted over time. Reporters identifying as male dominated in numbers, spent more days in the field reporting and reported more species on each field day. Moreover, an age imbalance towards older participants amplified over time. As the first long-term study of citizen participation by age and gender, our results show that it is important for citizen science project developers to account for cultural and social developments that might exclude participants, and to engage with under- represented and younger participants. This could facilitate the breadth of engagement and learning across a larger societal landscape, ensure project longevity and biodiversity data representation (e.g. mitigate gender bias influence on the number of reports of different species groups).
|
|
| 29. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Chapter 12: The participatory epistemic cultures of citizen humanities: Bildung and epistemic subjects
- 2020
-
Ingår i: A History of Participation in Museums and Archives : Traversing Citizen Science and Citizen Humanities / edited By Per Hetland, Palmyre Pierroux, Line Esborg. - London & New York : Routledge. - 9780367186715 ; , s. 236-257
-
Bokkapitel (refereegranskat)abstract
- Archives and repositories have until lately been exclusively confined to university libraries and departments, accessible only to professional researchers. However, as information and communication technology and digitization initiatives developed, new formats emerged for opening up and distributing research in the humanities. Several citizen humanities projects have been launched, described as “open to anyone,” that present contributors with the opportunity to participate in the research process regardless of training or knowledge. In this chapter, we map out epistemological relations between professional researchers and contributors, exploring how citizens’ engagement has led to the development of a “participatory epistemic culture” in citizen humanities. The premise is that important features of this epistemic culture result from the invitation of outsiders into work in the humanities, forming unexpected relations between individualized and more distributed epistemic subjects in citizen humanities.
|
|
| 30. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Citizen Humanities: Configuring Interpretation and Perception for Participation
- 2016
-
Ingår i: Citizen Science – Innovation in Open Science, Society and Policy 19–21 May 2016, Berlin. ; , s. 26-27
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The history of volunteer participation in scientific work usually starts with ornithology in the late 19th century. Since then this practice has spread to many disciplines in the sciences. The success of such projects has to a large extent been a question of data quality and design of participatory protocols, which puts the contributor on par with the scientist as an observer of the natural world. The ability of the protocol to produce valid data, while also being inclusive enough to mobilize the volunteer contributors in large numbers, is still a challenge to citizen science (CS) projects. To enable the perceptual qualities of the contributor in mass observations, the cognitive thresholds have been kept low, thus making CS as inclusive as possible. However, with few exceptions, the humanities have not managed to facilitate broad public participation the same way as the sciences have. Nevertheless several citizen humanities (CH) projects have been launched lately on platforms such as Zooniverse, Scholars’ Lab and Micropast. As the humanities are generally associated with interpretation – a hard-earned ability acquired only through specialized studies (Bildung) – data is often perceived as inaccessible without training. Implied in hermeneutic ideals of knowledge, context is viewed as a prerequisite for informed interpretation. In this paper we are comparing how the design of participatory protocols in CS and CH are constructed, with special attention to where and how in the research process “citizen humanists” are put to work. Our empirical analysis consists of analyses of the online environments generated by a number of contemporary citizen humanities projects.
|
|
| 31. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Embedding Citizen Science in Research: Forms of engagement, scientific output and values for science, policy and society
- 2017
-
Ingår i: SocArXiv.
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper addresses emerging forms of Citizen Science (Citizen Science), and discusses their value for science, policy and society. It clarifies how the term Citizen Science is used and identifies different forms of Citizen Science. This is important, since with blurred distinctions there is a risk of both overrating and underestimating the value of Citizen Science and of misinterpreting what makes a significant contribution to scientific endeavour. The paper identifies three main forms of citizen science 1) Citizen Science as a research method, aiming for scientific output, 2) Citizen Science as public engagement, aiming to establish legitimacy for science and science policy in society, and, 3) Citizen Science as civic mobilization, aiming for legal or political influence in relation to specific issues. In terms of scientific output, the first form of Citizen Science exceeds the others in terms of scientific peer-reviewed articles. These projects build on strict protocols and rules for participation and rely on mass inclusion to secure the quality of contributions. Volunteers are invited to pursue very delimited tasks, defined by the scientists. The value of the three distinct forms of Citizen Science –for science, for policy and for society, is discussed to situate Citizen Science in relation to current policy initiatives in Europe and in the US. In quantitative terms the US, and particularly the NSF have so far taken a lead in allocating research funding to Citizen Science projects (primarily of the first form), however, the White House has recently issued a memorandum addressing societal and scientific challenges through citizen science covering all three forms discussed in this paper. As Citizen Science is currently being launched as a way to change the very landscape of science, important gaps in research are identified and policy recommendations are provided, in order for policy makers to be able to assess and anticipate the value of different forms of Citizen Science with regard to future research policy.
|
|
| 32. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Epistemic cultures in citizen science and humanities: Distribution, epistemic subjects, programs and anti-programs
- 2018
-
Ingår i: Meetings: Making, science, technology and society together. EASST2018, 25-28 July, Lancaster University. - Lancaster, UK : Lancaster University.
-
Konferensbidrag (refereegranskat)abstract
- Inclusion in epistemic cultures in citizen science and humanities projects are conditional, often relying on minimizing the realization of volunteers as epistemic subjects as a necessity for mass mobilization and distribution of tasks. However, such cultural processes are outside the control of owners of projects. Projects aiming for scientific output (peer-reviewed publications) must have an instance in the research process were citizens are constructed as on par with researchers to assure data quality. These instances are often situated in the participatory protocols (programs) harnessing some kind of ability of the crowd, which make their participation and contributions valid for research. At the same time, projects also uphold boundaries between citizens and researchers. Intuitively, this might not be necessary as researchers by their professional training have acquired abilities beyond volunteer contributors. In practice, such boundaries are not so clear. The aim of this paper is to present preliminary results from when and how such boundaries are challenged as epistemic subjects come into being beyond what is expected by owners of projects. The purpose is to illuminate the relationship between the citizen as constructed as a contributor to research with specific, but static qualities (programs), and the development of contributors over time, as epistemic subjects realizing themselves through anti-programs. Data consists of interactions in the epistemic cultures of researchers and contributors on discussion forums on platforms for citizen science and humanities projects.
|
|
| 33. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Joining Reference and Representation —Citizen Science as Resistance Practice
- 2015
-
Ingår i: Society for Social Studies of Science 2015 Annual Meeting November 11-14 Denver, Colorado.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- During the past two decades there has been an increased interest in citizen science. Citizens contribute to science in observing, classifying and collecting data. Several largescale scientific projects have successfully enrolled citizens in the research process (see, galaxyzoo.org; ebird.org). But, citizens are also regarded as deliberative stakeholders in the space between science and society. By participating in the democratic process, this version of a citizen scientist is able to speak for the local community, which is affected by the scientific society. These two types of citizen science seem to be incommensurable. Observing, classifying and collecting scientific facts is usually regarded as a domain that needs to be isolated from any other in society. When science is influenced by politics it looses its objectivity. Similarly, deliberative politics is often thought of as the complete opposite of scientific reasoning. However, there is a third type of citizen science that manages to both become producers of scientific facts and of deliberative politics. Such citizen science projects can, in some cases, be seen as challenging science and producing modified forms of science. Two such examples are the Louisiana Bucket Brigade (labucketbrigade.org), and International Rivers (internationalrivers.org). The purpose of this open panel is to bring forward further examples, both current and historical. What are the consequences of using standardized scientific methods to pursue political goals? Does it imply the end of politics or the end of science? Or is it a form of engagement that contributes to informed politics and more (locally) relevant science? Using the notion of a “crossing” between a political mode of existence, which constantly seeks representation, and a scientific mode of existence that struggles to create reference to the world, this open panel elaborates on how this crossing is traversed, negotiated, denied and defended in citizen science as resistance.
|
|
| 34. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Medborgarforskning och vetenskapens demokratisering : Rapport R3:2018
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport behandlar medborgarforskning som en central aspekt av diskussionerna om vetenskapens demokratisering. Rapporten ventilerar förväntningar, det allmänna förtroendet för vetenskap och de ökade krav på demokratisering av den vetenskapliga processen som hörs från politisk nivå i samband med sådana initiativ. De begynnande etiska diskussionerna kring medborgarforskning tas också upp.
|
|
| 35. |
|
|
| 36. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
The many modes of citizen science: Editorial
- 2019
-
Ingår i: Science & Technology Studies. - : Science and Technology Studies. - 2243-4690. ; 32:2, s. 2-8
-
Tidskriftsartikel (refereegranskat)abstract
- This special issue of Science and Technology Studies is concerned with the epistemological and ontological diversity of citizen science, and the sometimes contested attempts to define it, as an interesting and fruitful phenomenon to explore from vantage points or perspectives in STS. During the past two decades there has been an increasing interest in this phenomenon, and currently citizen science is being introduced as a way to change the very landscape and culture of science. However, in contrast to such general accounts, this special issue seeks to unpack citizen science, and instead approach it not as one, but as several different modes of social epistemologies. These diverse modes also instantiate a wide range of imagined epistemic agents; ‘the citizen’, ‘the volunteer’, ‘the participant’, ‘the crowd’, ‘the activist’, ‘the community’ et cetera - agents that in one way or another perform scientific research without being a professional scientist.
|
|
| 37. |
- Kasperowski, Dick, 1959, et al.
(författare)
-
Where Environmental Citizen Science Meets the Law
- 2023
-
Ingår i: Citizen Science: Theory & Practice. - : Ubiquity Press, Ltd.. - 2057-4991. ; 8:1, s. 1-4
-
Tidskriftsartikel (refereegranskat)abstract
- Citizen science often intersects with the legal realm. Communities in different places in the world are demanding environmental justice through civic monitoring (Haklay and Francis 2018) and are pushing for new regulatory standards (Ottinger 2010). Community-based monitoring has been explored in the literature from both the (global and relative) North and South as a creative and constructive response to citizens’ aspiration for justice (Berti Suman 2022; Ahmed et al. 2019; Haklay and Francis 2018). Citizen science broadens the new horizon of environmental justice and flanks traditional environmental (and climate) protest movements (Berti Suman, Schade and Abe 2020). We can identify also a claim to epistemological justice in the systematizing of local knowledge and observations into data that can be used by appointed agencies, in opposition to anecdotal and sporadic evidence (Balazs and Morello-Frosch 2013). Citizen science communities are getting their evidence accepted in court (as the US Formosa case illustrated in Berti Suman and Schade 2021 demonstrates) and are advocating for legitimizing the practice under the Aarhus framework (Berti Suman et al. 2023, in this special issue; Berti Suman 2020). In spite of this, research on the connections between the law, case law, and citizen science is scarce.
|
|
| 38. |
- Kullenberg, Christopher, 1980, et al.
(författare)
-
What Is Citizen Science? – A Scientometric Meta-Analysis
- 2016
-
Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Context The concept of citizen science (CS) is currently referred to by many actors inside and outside science and research. Several descriptions of this purportedly new approach of science are often heard in connection with large datasets and the possibilities of mobilizing crowds outside science to assists with observations and classifications. However, other accounts refer to CS as a way of democratizing science, aiding concerned communities in creating data to influence policy and as a way of promoting political decision processes involving environment and health. Objective In this study we analyse two datasets (N = 1935, N = 633) retrieved from the Web of Science (WoS) with the aim of giving a scientometric description of what the concept of CS entails. We account for its development over time, and what strands of research that has adopted CS and give an assessment of what scientific output has been achieved in CS-related projects. To attain this, scientometric methods have been combined with qualitative approaches to render more precise search terms. Results Results indicate that there are three main focal points of CS. The largest is composed of research on biology, conservation and ecology, and utilizes CS mainly as a methodology of collecting and classifying data. A second strand of research has emerged through geographic information research, where citizens participate in the collection of geographic data. Thirdly, there is a line of research relating to the social sciences and epidemiology, which studies and facilitates public participation in relation to environmental issues and health. In terms of scientific output, the largest body of articles are to be found in biology and conservation research. In absolute numbers, the amount of publications generated by CS is low (N = 1935), but over the past decade a new and very productive line of CS based on digital platforms has emerged for the collection and classification of data.
|
|
| 39. |
- Lembrechts, Jonas J., et al.
(författare)
-
Global maps of soil temperature
- 2022
-
Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 28:9, s. 3110-3144
-
Tidskriftsartikel (refereegranskat)abstract
- Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1-km2 resolution for 0–5 and 5–15cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1-km2 pixels (summarized from 8519 unique temperature sensors) across all the world's major terrestrial biomes, and coarse-grained air temperature estimates from ERA5-Land (an atmospheric reanalysis by the European Centre for Medium-Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10°C (mean=3.0±2.1°C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6±2.3°C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (−0.7±2.3°C). The observed substantial and biome-specific offsets emphasize that the projected impacts of climate and climate change on near-surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil-related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological applications.
|
|
| 40. |
- Lembrechts, Jonas J., et al.
(författare)
-
SoilTemp : A global database of near-surface temperature
- 2020
-
Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 26:11, s. 6616-6629
-
Tidskriftsartikel (refereegranskat)abstract
- Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long-term average thermal conditions at coarse spatial resolutions only. Hence, many climate-forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particularly important in relation to effects of observation height (e.g. vegetation, snow and soil characteristics) and in habitats varying in their exposure to radiation, moisture and wind (e.g. topography, radiative forcing or cold-air pooling). Since organisms living close to the ground relate more strongly to these microclimatic conditions than to free-air temperatures, microclimatic ground and near-surface data are needed to provide realistic forecasts of the fate of such organisms under anthropogenic climate change, as well as of the functioning of the ecosystems they live in. To fill this critical gap, we highlight a call for temperature time series submissions to SoilTemp, a geospatial database initiative compiling soil and near-surface temperature data from all over the world. Currently, this database contains time series from 7,538 temperature sensors from 51 countries across all key biomes. The database will pave the way toward an improved global understanding of microclimate and bridge the gap between the available climate data and the climate at fine spatiotemporal resolutions relevant to most organisms and ecosystem processes.
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
|
|
| 44. |
- Petrov, Dmitry, et al.
(författare)
-
Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging
- 2017
-
Ingår i: Machine learning in medical imaging. MLMI (Workshop). - Cham : Springer International Publishing. ; 10541, s. 371-378
-
Tidskriftsartikel (refereegranskat)abstract
- As very large studies of complex neuroimaging phenotypes become more common, human quality assessment of MRI-derived data remains one of the last major bottlenecks. Few attempts have so far been made to address this issue with machine learning. In this work, we optimize predictive models of quality for meshes representing deep brain structure shapes. We use standard vertex-wise and global shape features computed homologously across 19 cohorts and over 7500 human-rated subjects, training kernelized Support Vector Machine and Gradient Boosted Decision Trees classifiers to detect meshes of failing quality. Our models generalize across datasets and diseases, reducing human workload by 30-70%, or equivalently hundreds of human rater hours for datasets of comparable size, with recall rates approaching inter-rater reliability.
|
|
| 45. |
- Ponti, Marisa, et al.
(författare)
-
Designing Futures for Learning in the Crowd: New Challenges and Opportunities for CSCL : Workshop organized at the CSCL 2015, the 11th International Conference on Computer Supported Collaborative Learning
- 2015
-
Ingår i: Lindwall, O., Häkkinen, P., Koschman, T. Tchounikine, P. & Ludvigsen, S. (Eds.) (2015). Exploring the Material Conditions of Learning: The Computer Supported Collaborative Learning (CSCL) Conference. - 1573-4552. ; Vol. 2, s. 885-888
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 46. |
- Ponti, Marisa, 1959, et al.
(författare)
-
Getting It Right or Being Top Rank: Games in Citizen Science
- 2017
-
Ingår i: CSA 2017.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The use of games in citizen science is growing, but can create tension as these can be seen as incompatible areas of activity. For example, the motivations of winning a game and the scientific pursuit of knowledge may be seen as contrary. Over a one-year period, we conducted a virtual ethnographic study of the public forums of two online projects, Foldit and Galaxy Zoo (GZ). The first where gaming is an explicit design feature and the second where it is not. The aim was to give a nuanced view of how participants topicalize and respond to tension between games and science. Thematic analysis of the forum posts showed that participants in the two projects respond differently to the tension. GZ participants highlighted the value of sharing and openness to sustain a healthy community while Foldit participants expressed concern for the project becoming the exclusive playground of an ever-decreasing elite group. For example, leaderboards were portrayed as antithetical to a healthy community in GZ as scores bring unhealthy competition and adverse effects on scientific validity. By contrast, the notion that ranking performance could be antithetical to the spirit of science was not part of the established community repertoire for Foldit. By unpacking participant responses to the tension between games and science, our study highlights that citizen science projects using games are not just about fun. In order to enrol and retain volunteers, they must also recognize and manage the implicit normative scientific ideals participants bring with them to a project.
|
|
| 47. |
- Ponti, Marisa, 1959, et al.
(författare)
-
Getting it Right or Being Top Rank: Games in Citizen Science
- 2018
-
Ingår i: Citizen Science - Theory and Practice. - : Ubiquity Press, Ltd.. - 2057-4991. ; 3:1, s. 1-10
-
Tidskriftsartikel (refereegranskat)abstract
- The use of games in citizen science is growing, but can create tension as gaming and science can be seen as incompatible areas of activity. For example, the motivations for winning a game and scientific pursuit of knowledge may be seen as contrary. Over a one-year period, we conducted a virtual ethnographic study of the public forums of two online citizen science projects, Foldit and Galazy Zoo, the first a project in which gaming is an explicit design feature and the second in which it is not. The aim was to provide a nuanced view of how participants topicalize and respond to tensions between gaming and science. Thematic analysis of discussion forum posts suggests that participants in the two projects respond differently to the tension. By unpacking participant responses to the tension between games and science, our study highlights that citizen science projects using games are not just about fun. To enroll and retain volunteers, these projects also must recognize and manage the implicit normative scientific ideals that participants bring with them to a project. We further conclude that ideals of science embraced by citizen scientists appear to influence the reasons why they participate, either emphasizing equality, like in Galazy Zoo, or meritocracy, like in Foldit.
|
|
| 48. |
- Rohden, Frauke, 1991, et al.
(författare)
-
Tagging, Pinging and Linking – User Roles in Virtual Citizen Science Forums.
- 2019
-
Ingår i: Citizen Science: Theory and Practice. - : Ubiquity Press, Ltd.. - 2057-4991. ; 4:1, s. 1-13
-
Tidskriftsartikel (refereegranskat)abstract
- This article investigates user roles in virtual citizen science projects through a case study of the Talk-forum of Shakespeare’s World, a humanities project on the Zooniverse platform. To address collective knowledge production, we study the use of hashtags, pinging, and linking as a way of differentiating how researchers, moderators, and different user groups use the forum according to their roles. We show how both volunteers and researchers have a much deeper interest in the texts that they transcribe and actively seek contextual information, shape new lines of inquiry, and discover new phenomena. We conclude that the use of online forums in citizen science can play a crucial role for extending the knowledge production from academic research to a wider public interest, and also provide new knowledges beyond the assigned task of transcribing documents.
|
|
| 49. |
- Süess, Philip, 1988-, et al.
(författare)
-
Time- and temperature-dependent dynamics of prothoracicotropic hormone and ecdysone sensitivity co-regulate pupal diapause in the green-veined white butterfly Pieris napi
- 2022
-
Ingår i: Insect Biochemistry and Molecular Biology. - : Elsevier BV. - 0965-1748 .- 1879-0240. ; 149
-
Tidskriftsartikel (refereegranskat)abstract
- Diapause, a general shutdown of developmental pathways, is a vital adaptation allowing insects to adjust their life cycle to adverse environmental conditions such as winter. Diapause in the pupal stage is regulated by the major developmental hormones prothoracicotropic hormone (PTTH) and ecdysone. Termination of pupal diapause in the butterfly Pieris napi depends on low temperatures; therefore, we study the temperature-dependence of PTTH secretion and ecdysone sensitivity dynamics throughout diapause, with a focus on diapause termination. While PTTH is present throughout diapause in the cell bodies of two pairs of neurosecretory cells in the brain, it is absent in the axons, and the PTTH concentration in the haemolymph is significantly lower during diapause than during post diapause development, indicating that the PTTH signaling is reduced during diapause. The sensitivity of pupae to ecdysone injections is dependent on diapause stage. While pupae are sensitive to ecdysone during early diapause initiation, they gradually lose this sensitivity and become insensitive to non-lethal concentrations of ecdysone about 30 days into diapause. At low temperatures, reflecting natural overwintering conditions, diapause termination propensity after ecdysone injection is precocious compared to controls. In stark contrast, at high temperatures reflecting late summer and early autumn conditions, sensitivity to ecdysone does not return. Thus, here we show that PTTH secretion is reduced during diapause, and additionally, that the low ecdysone sensitivity of early diapause maintenance is lost during termination in a temperature dependent manner. The link between ecdysone sensitivity and low-temperature dependence reveals a putative mechanism of how diapause termination operates in insects that is in line with adaptive expectations for diapause.
|
|
| 50. |
- Södersten, Fredrik, et al.
(författare)
-
Immunolocalization of Collagens (I and III) and Cartilage Oligomeric Matrix Protein in the Normal and Injured Equine Superficial Digital Flexor Tendon
- 2013
-
Ingår i: Connective Tissue Research. - : Informa UK Limited. - 1607-8438 .- 0300-8207. ; 54:1, s. 62-69
-
Tidskriftsartikel (refereegranskat)abstract
- This is a descriptive study of tendon pathology with different structural appearances of repair tissue correlated to immunolocalization of cartilage oligomeric matrix protein (COMP) and type I and III collagens and expression of COMP mRNA. The material consists of nine tendons from seven horses (5-25 years old; mean age of 10 years) with clinical tendinopathy and three normal tendons from horses (3, 3, and 13 years old) euthanized for non-orthopedic reasons. The injured tendons displayed different repair-tissue appearances with organized and disorganized fibroblastic regions as well as areas of necrosis. The normal tendons presented distinct immunoreactivity for COMP and expression of COMP mRNA and type I collagen in the normal aligned fiber structures, but no immunolabeling of type III collagen. However, immunoreactivity for type III collagen was present in the endotenon surrounding the fiber bundles, where no expression of COMP could be seen. Immunostaining for type I and III collagens was present in all of the pathologic regions indicating repair tissue. Interestingly, the granulation tissues showed immunostaining for COMP and expression of COMP mRNA, indicating a role for COMP in repair and remodeling of the tendon after fiber degeneration and rupture. The present results suggest that not only type III collagen but also COMP is involved in the repair and remodeling processes of the tendon.
|
|
