| 1. |
- Dittmar, Jakob, 1971-, et al.
(författare)
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Teaching Methods for Drawing and Visual Narratives
- 2021
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Due to Covid19, all teaching on our comics courses has been moved online, including workshops and exercises on drawing, image composition, and development of visual narratives. As the focus is on sketching and sequence composition processes, as critique and reflection is closely connected to work-in-progress, the move to distance teaching has removed the partners in these processes and conversations from one another. With tight budgets, no dedicated software-licences are bought, but the idea is to use what we have and add as little necessary freeware as needed / possible. While lecturing on and introducing to theoretical backgrounds, techniques, and examples on distance has continued to work quite well, the need to optimise student learning on online design assignments and workshops has been a challenge. It was understood before we had to move all teaching online that developing drawing skills as well as advancing the understanding of pictorial sequential narratives depends on continuous feedback between teachers and students as well as peer-learning between the students. But in practice, this has been the biggest challenge. We have been forced to develop alternative strategies and methods for teaching visual composition processes, showcasing as well as exercising comics-production processes. Didactic strategies have been developed to overcome the restrictions caused by online low-resolution visuals, the inability to unobtrusively observe and participate in design processes, to involve all students actively in critique-sessions, etc. In due consequence, we are putting together a kind of tool-box for teaching and workshopping on visual gestaltung online. We would like to present the results and invite the participants of this workshop to play through and discuss them to help us understand what is needed to make them work for other teachers on other courses that teach visualising / drawing / visual narratives.
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| 2. |
- Dittmar, M, et al.
(författare)
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Parton distributions: Summary report for the HERA - LHC workshop
- 2005
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Konferensbidrag (populärvet., debatt m.m.)abstract
- We provide an assessment of the impact of parton distributions on the determination of LHC processes, and of the accuracy with which parton distributions (PDFs) can be extracted from data, in particular from current and forthcoming HERA experiments. We give an overview of reference LHC processes and their associated PDF uncertainties, and study in detail W and Z production at the LHC. We discuss the precision which may be obtained from the analysis of existing HERA data, tests of consistency of HERA data from different experiments, and the combination of these data. We determine further improvements on PDFs which may be obtained from future HERA data (including measurements of $F_L$), and from combining present and future HERA data with present and future hadron collider data. We review the current status of knowledge of higher (NNLO) QCD corrections to perturbative evolution and deep-inelastic scattering, and provide reference results for their impact on parton evolution, and we briefly examine non-perturbative models for parton distributions. We discuss the state-of-the art in global parton fits, we assess the impact on them of various kinds of data and of theoretical corrections, by providing benchmarks of Alekhin and MRST parton distributions and a CTEQ analysis of parton fit stability, and we briefly presents proposals for alternative approaches to parton fitting. We summarize the status of large and small x resummation, by providing estimates of the impact of large x resummation on parton fits, and a comparison of different approaches to small x resummation, for which we also discuss numerical techniques.
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| 3. |
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| 4. |
- Stanchev, Lyubomir D., et al.
(författare)
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Functional significance of conserved cysteines in the extracellular loops of the atp binding cassette transporter pdr11p
- 2021
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Ingår i: Journal of Fungi. - : MDPI. - 2309-608X. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The pleiotropic drug resistance (PDR) transporter Pdr11p is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae, where it facilitates the uptake of exogenous sterols. Members of the fungal PDR family contain six conserved cysteines in their extracellular loops (ECL). For the functional analysis of these cysteine residues in Pdr11p, we generated a series of single cysteine-to-serine mutants. All mutant proteins expressed well and displayed robust ATPase activity upon purification. Mass-spectrometry analysis identified two cysteine residues (C582 and C603) in ECL3 forming a disulfide bond. Further characterization by cell-based assays showed that all mutants are compromised in facilitating sterol uptake, protein stability, and trafficking to the plasma membrane. Our data highlight the fundamental importance of all six extracellular cysteine residues for the functional integrity of Pdr11p and provide new structural insights into the PDR family of transporters.
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| 5. |
- Stock, Kristin, et al.
(författare)
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Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
- 2012
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 18:8, s. 1232-1232
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Tidskriftsartikel (refereegranskat)abstract
- Primary astrocytomas of grade 3 or 4 according to the classification system of the World Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and are almost invariably fatal despite the use of multimodal therapy. Here we show that the juvenile brain has an endogenous defense mechanism against HGAs. Neural precursor cells (NPCs) migrate to HGAs, reduce glioma expansion and prolong survival time by releasing endovanilloids that activate the vanilloid receptor (transient receptor potential vanilloid subfamily member-1 or TRPV1) on HGA cells. TRPV1 is highly expressed in tumor and weakly expressed in tumor-free brain. TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3). The antitumorigenic response of NPCs is lost with aging. NPC-mediated tumor suppression can be mimicked in the adult brain by systemic administration of the synthetic vanilloid arvanil, suggesting that TRPV1 agonists have potential as new HGA therapeutics.
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