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Sökning: WFRF:(Don Kristine)

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1.
  • Engblom, Rikard, 1988- (författare)
  • Time Warps : Refugees and the Experience of Waiting in Rural Sweden
  • 2023
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This thesis explores the ways in which refugees’ experience of time is warped when they come to Sweden. It is based on fourteen months of ethnographic fieldwork in Avesta, a small municipality in rural Sweden.Refugee reception and immigration control in Sweden is characterized by humanitarian ideals that exist in tension with practices and policies aiming to restrict immigration in the name of security and stability. Each chapter of this thesis documents a different combination of these ideals and concerns, examining how they generate particular configurations of waiting. For many refugees in Sweden, everyday life is characterized by waiting—waiting to have their asylum application processed; to receive a residence permit, which grants them the right to work; to be reunited with their families to find a place in Swedish society. This process often takes several years, during which the conditions for receiving residence permit may suddenly change or be made more difficult. The thesis is a contribution to the recent “temporal turn” in migration studies through its focus on waiting as a productive phenomenon in vulnerable circumstances. The increased presence of refugees has given rise to anti-immigrant sentiments in Sweden, but it has also generated welcoming, compassionate responses. By addressing not only how refugees cope with living in a continual state of waiting under precarious conditions, but also how bureacracies, civil societies, and individuals respond to this waiting, the thesis discusses the sociological and ethical implications of refugees’ waiting. Time Warps demonstrates the importance of unpacking combinations of humanitarianism and securitarianism when developing a deepened understanding of refugees experience of waiting in rural Sweden.
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2.
  • Nallu, Sumitha, et al. (författare)
  • The molecular genetic basis of herbivory between butterflies and their host plants
  • 2018
  • Ingår i: Nature Ecology & Evolution. - : Springer Science and Business Media LLC. - 2397-334X. ; 2:9, s. 1418-1427
  • Tidskriftsartikel (refereegranskat)abstract
    • Interactions between herbivorous insects and their host plants are a central component of terrestrial food webs and a critical topic in agriculture, where a substantial fraction of potential crop yield is lost annually to pests. Important insights into plant-insect interactions have come from research on specific plant defences and insect detoxification mechanisms. Yet, much remains unknown about the molecular mechanisms that mediate plant-insect interactions. Here we use multiple genome-wide approaches to map the molecular basis of herbivory from both plant and insect perspectives, focusing on butterflies and their larval host plants. Parallel genome-wide association studies in the cabbage white butterfly, Pieris rapae, and its host plant, Arabidopsis thaliana, pinpointed a small number of butterfly and plant genes that influenced herbivory. These genes, along with much of the genome, were regulated in a dynamic way over the time course of the feeding interaction. Comparative analyses, including diverse butterfly/plant systems, showed a variety of genome-wide responses to herbivory, as well as a core set of highly conserved genes in butterflies as well as their host plants. These results greatly expand our understanding of the genomic causes and evolutionary consequences of ecological interactions across two of nature's most diverse taxa, butterflies and flowering plants.
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3.
  • Shu, Xiang, et al. (författare)
  • Associations of obesity and circulating insulin and glucose with breast cancer risk : a Mendelian randomization analysis
  • 2019
  • Ingår i: International Journal of Epidemiology. - : OXFORD UNIV PRESS. - 0300-5771 .- 1464-3685. ; 48:3, s. 795-806
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. Results: All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p = 5.09 x 10(-4)], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p = 4.02 x 10(-4)), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p = 5.05 x 10(-19)) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p = 9.22 x 10(-6)). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. Conclusions: We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.
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