| 1. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 2. |
- Ahrens, J, et al.
(författare)
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First measurement of the helicity-dependent (gamma)over-right-arrow(p)over-right-arrow -> p eta differential cross-section
- 2003
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 17:2, s. 241-244
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Tidskriftsartikel (refereegranskat)abstract
- The helicity dependence of the (γ) over right arrow(p) over right arrow -+ peta reaction has been measured for the first time at a center-of-mass angle theta(eta)*= 70degrees in the photon energy range from 780 MeV to 790 MeV. The experiment, performed at the Mainz microtron MAMI, used a 4pi-detector system, a circularly polarized, tagged photon beam. and a longitudinally polarized frozen-spin target. The helicity 3/2 cross-section is found to be small and the results for helicity 1/2 agree with predictions from the MAID analysis.
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| 3. |
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| 4. |
- Ahrens, J, et al.
(författare)
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Helicity dependence of the gamma p -> N pi channels and multipole analysis in the Delta region
- 2004
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 21:2, s. 323-333
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Tidskriftsartikel (refereegranskat)abstract
- A high-quality double-polarization data set for the helicity dependence of the total and differential cross-sections for both gammap --> Npi channels in the Delta region has been obtained in the framework of the GDH experiment. The experiment, performed at the Mainz microtron MAMI, used a 4pi detection system, a circularly polarized photon beam, and a longitudinally polarized frozen-spin target. These data are included in the database to perform a multipole analysis to determine the properties of the Delta(1232)-resonance. For the resonant Delta(1232) multipoles we find a very good agreement with previous analyses, while the nonresonant ones show significant deviations.
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| 5. |
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| 6. |
- Silvotti, R., et al.
(författare)
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EPIC 216747137 : a new HW Vir eclipsing binary with a massive sdOB primary and a low-mass M-dwarf companion
- 2021
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 500:2, s. 2461-2474
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Tidskriftsartikel (refereegranskat)abstract
- EPIC 216747137 is a new HW Virginis system discovered by the Kepler spacecraft during its K2 'second life'. Like the other HW Vir systems, EPIC 216747137 is a post-common-envelope eclipsing binary consisting of a hot subluminous star and a cool low-mass companion. The short orbital period of 3.87 h produces a strong reflection effect from the secondary (similar to 9 per cent in the R band). Together with AA Dor and V1828 Aql, EPIC 216747137 belongs to a small subgroup of HW Vir systems with a hot evolved sdOB primary. We find the following atmospheric parameters for the hot component: T-eff = 40400 +/- 1000 K, log g = 5.56 +/- 0.06, and log(N(He)/N(H)) = -2.59 +/- 0.05. The sdOB rotational velocity v sin i = 51 +/- 10 km s(-1) implies that the stellar rotation is slower than the orbital revolution and the system is not synchronized. When we combine photometric and spectroscopic results with the Gaia parallax, the best solution for the system corresponds to a primary with a mass of about 0.62 M-circle dot close to, and likely beyond, the central helium exhaustion, while the cool M-dwarf companion has a mass of about 0.11 M-circle dot.
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