| 1. |
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| 2. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 3. |
- Chen, Fei-Jian, et al.
(författare)
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Structure-direction towards the new large pore zeolite NUD-3
- 2021
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Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 57:2, s. 191-194
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Tidskriftsartikel (refereegranskat)abstract
- The new zeolite NUD-3 possesses a three-dimensional system of large pore channels that is topologically identical to those of ITQ-21 and PKU-14. However, the three zeolites have distinctly different frameworks: a particular single 4-membered ring inside the denser portion of the zeolite is missing in PKU-14, disordered in ITQ-21 and fully ordered in NUD-3. We document these differences and use molecular simulations to unravel the mechanism by which a particular structure directing agent dication, 1,1′-(1,2-phenylenebis(methylene))bis(3-methylimidazolium), is able to orient this inner ring.
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| 4. |
- Fenstermacher, M.E., et al.
(författare)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 5. |
- Thrift, Aaron P., et al.
(författare)
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Mendelian randomization study of height and risk of colorectal cancer
- 2015
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 44:2, s. 662-672
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Tidskriftsartikel (refereegranskat)abstract
- Background: For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk. Methods: To minimize confounding and bias, we derived a weighted genetic risk score predicting height (using 696 genetic variants associated with height) in 10 226 CRC cases and 10 286 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height, genetically predicted height and CRC. Results: Using conventional methods, increased height (per 10-cm increment) was associated with increased CRC risk (OR = 1.08, 95% CI = 1.02-1.15). In sex-specific analyses, height was associated with CRC risk for women (OR = 1.15, 95% CI = 1.05-1.26), but not men (OR = 0.98, 95% CI = 0.92-1.05). Consistent with these results, carrying greater numbers of (weighted) height-increasing alleles (per 1-unit increase) was associated with higher CRC risk for women and men combined (OR = 1.07, 95% CI = 1.01-1.14) and for women (OR = 1.09, 95% CI = 1.01-1.19). There was weaker evidence of an association for men (OR = 1.05, 95% CI = 0.96-1.15). Conclusion: We provide evidence for a causal association between height and CRC for women. The CRC-height association for men remains unclear and warrants further investigation in other large studies.
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| 6. |
- Wang, Rongsheng, et al.
(författare)
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Asymmetry in the current sheet and secondary magnetic flux ropes during guide field magnetic reconnection
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117, s. A07223-
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Tidskriftsartikel (refereegranskat)abstract
- A magnetic reconnection event with a moderate guide field encountered by Cluster in the near-Earth tail on 28 August 2002 is reported. The guide field points dawnward during this event. The quadrupolar structure of the Hall magnetic field within the ion diffusion region is distorted toward the northern hemisphere in the earthward part while toward the southern hemisphere tailward part of X-line. Observations of current density and electron pitch angle distribution indicate that the distorted quadrupolar structure is formed due to a deformed Hall electron current system. Cluster crossed the ion diffusion region from south to north earthward of the X-line. An electron density cavity is confirmed in the northern separatrix layer while a thin current layer (TCL) is measured in the southern separatrix layer. The TCL is formed due to electrons injected into the X-line along the magnetic field. These observations are different from simulation results where the cavity is produced associated with inflow electrons along the southern separatrix while the strong current sheet appears with the outflow electron beam along the northern separatrix. The energy of the inflowing electron in the separatrix layer could extend up to 10 keV. Energetic electron fluxes up to 50 keV have a clear peak in the TCL. The length of the separatrix layer is estimated to be at least 65 c/omega(pi). These observations suggest that electrons could be pre-accelerated before they are ejected into the X-line region along the separatrix. Multiple secondary flux ropes moving earthward are observed within the diffusion region. These secondary flux ropes are all identified earthward of the observed TCL. These observations further suggest there are numerous small scale structures within the ion diffusion region.
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| 7. |
- An, Pengcheng, et al.
(författare)
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EmoWear: Exploring Emotional Teasers for Voice Message Interaction on Smartwatches
- 2024
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Ingår i: Conference on Human Factors in Computing Systems - Proceedings.
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Konferensbidrag (refereegranskat)abstract
- Voice messages, by nature, prevent users from gauging the emotional tone without fully diving into the audio content. This hinders the shared emotional experience at the pre-retrieval stage. Research scarcely explored “Emotional Teasers”-pre-retrieval cues offering a glimpse into an awaiting message's emotional tone without disclosing its content. We introduce EmoWear, a smartwatch voice messaging system enabling users to apply 30 animation teasers on message bubbles to reflect emotions. EmoWear eases senders' choice by prioritizing emotions based on semantic and acoustic processing. EmoWear was evaluated in comparison with a mirroring system using color-coded message bubbles as emotional cues (N=24). Results showed EmoWear significantly enhanced emotional communication experience in both receiving and sending messages. The animated teasers were considered intuitive and valued for diverse expressions. Desirable interaction qualities and practical implications are distilled for future design. We thereby contribute both a novel system and empirical knowledge concerning emotional teasers for voice messaging.
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| 8. |
- Du, Fang K., et al.
(författare)
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Direction and extent of organelle DNA introgression between two spruce species in the Qinghai-Tibetan Plateau
- 2011
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Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 192:4, s. 1024-1033
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Tidskriftsartikel (refereegranskat)abstract
- A recent model has shown that, during range expansion of one species in a territory already occupied by a related species, introgression should take place preferentially from the resident species towards the invading species and genome components experiencing low rates of gene flow should introgress more readily than those experiencing high rates of gene flow. Here, we use molecular markers from two organelle genomes with contrasted rates of gene flow to test these predictions by examining genetic exchanges between two morphologically distinct spruce Picea species growing in the Qinghai-Tibetan Plateau. The haplotypes from both mitochondrial (mt) DNA and chloroplast (cp) DNA cluster into two distinct lineages that differentiate allopatric populations of the two species. By contrast, in sympatry, the species share the same haplotypes, suggesting interspecific genetic exchanges. As predicted by the neutral model, all sympatric populations of the expanding species had received their maternally inherited mtDNA from the resident species, whereas for paternally inherited cpDNA introgression is more limited and not strictly unidirectional. Our results underscore cryptic introgressions of organelle DNAs in plants and the importance of considering rates of gene flow and range shifts to predict direction and extent of interspecific genetic exchanges.
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| 9. |
- Du, Hao, et al.
(författare)
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Easily recyclable lithium-ion batteries : Recycling-oriented cathode design using highly soluble LiFeMnPO4 with a water-soluble binder
- 2023
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Ingår i: Battery Energy. - : John Wiley & Sons. - 2768-1688 .- 2768-1696. ; 2:4, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Recycling lithium-ion batteries (LIBs) is fundamental for resource recovery, reducing energy consumption, decreasing emissions, and minimizing environmental risks. The inherited properties of materials and design are not commonly attributed to the complexity of recycling LIBs and their effects on the recycling process. The state-of-the-art battery recycling methodology consequently suffers from poor recycling efficiency and high consumption from issues with the cathode and the binder material. As a feasibility study, high-energy-density cathode material LiFeMnPO4 with a water-soluble polyacrylic acid (PAA) binder is extracted with dilute hydrochloric acid at room temperature under oxidant-free conditions. The cathode is wholly leached with high purity and is suitable for reuse. The cathode is easily separated from its constituent materials and reduces material and energy consumption during recycling by 20% and 7%, respectively. This strategy is utilized to fabricate recyclable-oriented LiFeMnPO4/graphite LIBs with a PAA binder and carbon paper current collector. Finally, the limitation of the solubility of the binder is discussed in terms of recycling. This research hopefully provides guidance for recycling-oriented design for the circular economy of the LIB industry.
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| 10. |
- Du, Hao, et al.
(författare)
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Recovery of lithium salt from spent lithium-ion battery by less polar solvent wash and water extraction
- 2023
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Ingår i: Carbon Neutralization. - : John Wiley & Sons. - 2769-3325 .- 2769-3325. ; 2:4, s. 416-424
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Tidskriftsartikel (refereegranskat)abstract
- The lithium hexafluorophosphate (LiPF6) in spent lithium-ion batteries (LIBs) is a potentially valuable resource and a significant environmental pollutant. Unfortunately, most of the LiPF6 in a spent LIB is difficult to extract because the electrolyte is strongly adsorbed by the cathode, anode, and separator. Storing extracted electrolyte is also challenging because it contains LiPF6, which promotes the decomposition of the solvent. Here we show that electrolytes in spent LIBs can be collected by a less polar solvent dimethyl carbonate (DMC) wash, and LiPF6 can be concentrated by simple aqueous extraction by lowering ethylene carbonate (EC) content in the recycled electrolyte. Due to the similar dielectric constant of EC and water, reducing the content of EC in LIB electrolytes, or even eliminating it, facilitates the separation of water and electrolyte, thus enabling the lithium salts in the electrolyte to be separated from the organic solvent. The lithium salt extracting efficiency achieved in this way can be as high as 99.8%, and fluorine and phosphorus of LiPF6 can be fixed in the form of stable metal fluoride and phosphate by hydrothermal method. The same strategy can be used in industrial waste electrolyte recycling by diluting the waste with DMC and extracting the resulting solution with water. This work thus reveals a new route for waste electrolyte treatment and will also support the development of advanced EC-free electrolytes for high-performance, safe, and easily recyclable LIBs.
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| 11. |
- Du, Jian, et al.
(författare)
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2D materials for solar fuels via artificial photosynthesis
- 2022
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Ingår i: National Science Review. - : Oxford University Press (OUP). - 2095-5138 .- 2053-714X. ; 9:5
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Tidskriftsartikel (refereegranskat)abstract
- To accelerate the chemical processes of water splitting, CO2 reduction and N2 fixation in artificial photosynthetic systems, various strategies to improve the properties of 2D materials with catalysts are highlighted in this perspective.
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| 12. |
- Du, Jiangfeng, et al.
(författare)
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An experimental observation of geometric phases for mixed states using NMR interferometry
- 2003
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 91:10, s. 100403-
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Tidskriftsartikel (refereegranskat)abstract
- Examples of geometric phases abound in many areas of physics. They offer both fundamental insights into many physical phenomena and lead to interesting practical implementations. One of them, as indicated recently, might be an inherently fault-tolerant quantum computation. This, however, requires to deal with geometric phases in the presence of noise and interactions between different physical subsystems. Despite the wealth of literature on the subject of geometric phases very little is known about this very important case. Here we report the first experimental study of geometric phases for mixed quantum states. We show how different they are from the well understood, noiseless, pure-state case.
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| 13. |
- Du, Jian, et al.
(författare)
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Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
- 2012
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Ingår i: International Journal of Molecular Medicine. - : Spandidos Publications. - 1107-3756 .- 1791-244X. ; 29:4, s. 607-612
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Tidskriftsartikel (refereegranskat)abstract
- Alpinetin is a novel plant flavonoid derived from Alpinia katsumadai Hayata, found to possess strong anticancer effects. However, the antitumor effect of alpinetin on pancreatic cancer cells and the detailed mechanism remain unclear. The aim of this study was to investigate alpinetin's beneficial effect on pancreatic cancer and the possible molecular mechanism involved. Pancreatic cancer cell lines were treated with alpinetin at various doses and for different times, and the effect of alpinetin on cell growth inhibition, apoptosis and the cell cycle was determined. The expression of Bcl-2, Bcl-xL, XIAP and Bax, the activity of caspases and the levels of cytochrome c released were measured. The results showed that alpinetin inhibited the viability of three pancreatic cancer cell lines and induced apoptosis of BxPC-3 cells in a dose- and time-dependent manner. This was accompanied by regulation of the expression of Bcl-2, Bcl-xL, Bax and XIAP. Furthermore, alpinetin treatment led to the release of cytochrome c and activation of caspases-3, -8 and -9 proteins. Taken together, our studies indicate that alpinetin inhibited the proliferation of pancreatic cancer cells possibly through the regulation of the Bcl-2 family and XIAP expression, release of cytochrome c and the activation of caspases. Alpinetin may serve as a potential agent for the development of pancreatic cancer cell therapies.
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| 14. |
- Du, Jian, et al.
(författare)
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Cu3P/CuO Core-Shell Nanorod Arrays as High-Performance Electrocatalysts for Water Oxidation
- 2018
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Ingår i: ChemElectroChem. - : Wiley-VCH Verlagsgesellschaft. - 2196-0216. ; 5:15, s. 2064-2068
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Tidskriftsartikel (refereegranskat)abstract
- Earth-abundant transition-metal-based oxides are potential candidates to replace the state-of-the-art noble-metal-based oxygen evolution catalysts (OECs) such as IrO2 and RuO2. Despite the low cost and large abundance, copper-based OER catalysts have been less frequently studied, mainly owing to the low electrical conductivity of copper oxides that results in large overpotential and sluggish kinetics for oxygen evolution. We report here the insitu fabrication of semi-metallic Cu3P nanorod arrays on commercial copper foam via a template approach; the resulting self-supported core-shell Cu-Cu3P/CuO electrode has the merits of high electrical conductivity, large active area, and short diffusion paths for electrolyte and evolved oxygen, exhibiting a low overpotential of 315mV and high durability over 50h at a current density of 10mAcm(-2) for OER in 1.0 M KOH. The remarkable OER performance reported here is not only superior to that of analogous Cu-CuO foam electrode, but also outperforms those of copper-based OER electrocatalysts in the literature.
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| 15. |
- Du, Jian, et al.
(författare)
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Iron carbonate hydroxide templated binary metal-organic frameworks for highly efficient electrochemical water oxidation
- 2019
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Ingår i: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 55:98, s. 14773-14776
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Tidskriftsartikel (refereegranskat)abstract
- Metal-organic frameworks (MOFs) are promising catalysts for electrochemical reactions. Herein, self-supported NiFe-MOF nanoplates grown on Ni foam (NF) were prepared with iron carbonate hydroxide nanosheets (FeCH NSs) as a semisacrificial template and evaluated for the electrocatalytic oxygen evolution reaction (OER). In this approach, the porous FeCH NSs not only serve as the iron source of NiFe-MOF, but also slow down the leaching of Ni ions from the substrate, thus playing a unique role in regulating the morphology of NiFe-MOF with reduced thickness and sizes, enabling rapid electron transfer and mass transport. The resultant NiFe-MOF/FeCH-NF electrode showed higher activity than FeCH template-free electrodes and superior OER performance over other MOF based binder-free OER electrodes. A current density of 10 mA cm(-2) was obtained at a low overpotential of 200 mV with excellent durability in alkaline solution. Raman and TEM measurements reveal the partial transformation of NiFe-MOF to hydroxide during water oxidation.
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| 16. |
- Du, Jian, et al.
(författare)
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Iron-Salen Complex and Co2+ Ion-Derived Cobalt-Iron Hydroxide/Carbon Nanohybrid as an Efficient Oxygen Evolution Electrocatalyst
- 2019
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Ingår i: Advanced Science. - : WILEY. - 2198-3844. ; 6:12
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Tidskriftsartikel (refereegranskat)abstract
- Metal-salen complexes are widely used as catalysts in numerous fundamental organic transformation reactions. Here, CoFe hydroxide/carbon nanohybrid is reported as an efficient oxygen evolution electrocatalyst derived from the in situ formed molecular Fe-salen complexes and Co2+ ions at a low temperature of 160 degrees C. It has been evidenced that Fe-salen as a molecular precursor facilitates the confined-growth of metal hydroxides, while Co2+ plays a critical role in catalyzing the transformation of organic ligand into nanocarbons and constitutes an essential component for CoFe hydroxide. The resulting Co1.2Fe/C hybrid material requires an overpotential of 260 mV at a current density of 10 mA cm(-2) with high durability. The high activity is contributed to uniform distribution of CoFe hydroxides on carbon layer and excellent electron conductivity caused by intimate contact between metal and nanocarbon. Given the diversity of molecular precursors, these results represent a promising approach to high-performance carbon-based water splitting catalysts.
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| 17. |
- Du, Jian, et al.
(författare)
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Metal-organic frameworks and their derivatives as electrocatalysts for the oxygen evolution reaction
- 2021
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Ingår i: Chemical Society Reviews. - : Royal Society of Chemistry (RSC). - 0306-0012 .- 1460-4744. ; 50:4, s. 2663-2695
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Forskningsöversikt (refereegranskat)abstract
- Electrochemical water splitting is an appealing and promising approach for energy conversion and storage. As a key half-reaction of electricity-driven water splitting, the oxygen evolution reaction (OER) is a sluggish process due to the transfer of four protons and four electrons. Therefore, development of low-cost and robust OER electrocatalysts is of great importance for improving the efficiency of water splitting. Based on the merits of high surface area, rich pore structure, diverse composition and well-defined metal centers, metal-organic frameworks (MOFs) and their derivatives have been widely exploited as OER electrocatalysts. Herein, the current progress on MOFs and their derivatives for OER electrolysis is summarized, highlighting the design principle, synthetic methods and performance for MOF-based materials. In addition, the structure-performance relationships of MOFs and their derivatives toward the OER are discussed, providing valuable insights into rationally developing OER catalysts with high efficiency. The current scientific and technological challenges and future perspectives towards the purpose of sustainable industrial applications are addressed at the end.
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| 18. |
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| 19. |
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| 20. |
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| 21. |
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| 22. |
- Du, Lin, et al.
(författare)
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Review of user parameter-free robust adaptive beamforming algorithms
- 2009
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Ingår i: Digital signal processing (Print). - : Elsevier BV. - 1051-2004 .- 1095-4333. ; 19:4, s. 567-582
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Forskningsöversikt (refereegranskat)abstract
- This paper provides a comprehensive review of user parameter-free robust adaptive beamforming algorithms. We present the ridge regression Capon beamformers (RRCBs), the mid-way (MW) algorithm, and the convex combination (CC) as well as the general linear combination (GLC) approaches. The purpose of these methods is to mitigate the effect of small sample size and steering vector errors on the standard Capon beamformer (SCB). We also present sparsity based iterative beamforming algorithms, namely the iterative adaptive approach (IAA), maximum likelihood based IAA (referred to as IAA-ML) and M-SBL (multi-snapshot sparse Bayesian learning), which exploit sparsity to estimate the signal parameters. We provide a thorough evaluation of these beamforming methods in terms of power and spatial spectrum estimation accuracies. output signal-to-interference-plusnoise ratio (SINR) and resolution under various scenarios including coherent, non-coherent and distributed sources, steering vector mismatches, snapshot limitations and low signal-to-noise ratio (SNR) levels. Furthermore, we discuss the computational complexities of the algorithms and provide insights into which algorithm is the best choice under which circumstances.
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| 23. |
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| 24. |
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| 25. |
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| 26. |
- Du, Mulong, et al.
(författare)
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Cyp2a6 activity and cigarette consumption interact in smoking-related lung cancer susceptibility
- 2024
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Ingår i: Cancer Research. - : American Association For Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 84:4, s. 616-625
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Tidskriftsartikel (refereegranskat)abstract
- Cigarette smoke, containing both nicotine and carcinogens, causes lung cancer. However, not all smokers develop lung cancer, highlighting the importance of the interaction between host susceptibility and environmental exposure in tumorigenesis. Here, we aimed to delineate the interaction between metabolizing ability of tobacco carcinogens and smoking intensity in mediating genetic susceptibility to smoking-related lung tumorigenesis. Single-variant and gene-based associations of 43 tobacco carcinogen–metabolizing genes with lung cancer were analyzed using summary statistics and individual-level genetic data, followed by causal inference of Mendelian randomization, mediation analysis, and structural equation modeling. Cigarette smoke–exposed cell models were used to detect gene expression patterns in relation to specific alleles. Data from the International Lung Cancer Consortium (29,266 cases and 56,450 controls) and UK Biobank (2,155 cases and 376,329 controls) indicated that the genetic variant rs56113850 C>T located in intron 4 of CYP2A6 was significantly associated with decreased lung cancer risk among smokers (OR = 0.88, 95% confidence interval = 0.85–0.91, P = 2.18 X 10-16), which might interact (Pinteraction = 0.028) with and partially be mediated (ORindirect = 0.987) by smoking status. Smoking intensity accounted for 82.3% of the effect of CYP2A6 activity on lung cancer risk but entirely mediated the genetic effect of rs56113850. Mechanistically, the rs56113850 T allele rescued the downregulation of CYP2A6 caused by cigarette smoke exposure, potentially through preferential recruitment of transcription factor helicase-like transcription factor. Together, this study provides additional insights into the interplay between host susceptibility and carcinogen exposure in smoking-related lung tumorigenesis.
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| 27. |
- Du, Wei, et al.
(författare)
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Effect of the broken rib locations on the heat transfer and fluid flow in a rotating latticework duct
- 2019
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Ingår i: Journal of Heat Transfer. - : ASME International. - 0022-1481 .- 1528-8943. ; 141:10
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Tidskriftsartikel (refereegranskat)abstract
- A numerical method was used to study the effect of the broken rib locations on the heat transfer and flow structure in the latticework duct with various rotational numbers. The latticework duct had eleven subchannels on both the pressure side and the suction side. The crossing angle for each subchannel was 45 deg. The numerical studies were conducted with five different broken rib locations and six rotational numbers (0–0.5). The Reynolds number was fixed as 44,000. The flow structure, wall shear stress, and Nusselt number distributions were analyzed. It was found that the upward spiral flow and helical flow dominated the flow structure in the latticework duct. In addition, the impingement region (at the beginning of the subchannel) induced by the upward spiral flow was responsible for the high Nusselt number and wall shear stress. After adoption of the broken rib in the latticework duct, the Nusselt number was increased by 6.12% on the pressure endwall surface and increased by 6.02% on the rib surface compared to the traditional latticework duct. As the rotational number was increased, the Nusselt number on the pressure endwall surface was decreased by up to 5.4%. However, the high rotational number enhanced the heat transfer on the suction side. The high rotational number also decreased the friction factor in the latticework duct. Furthermore, the overall thermal performance was increased by 12.12% after adoption of the broken ribs on both the turn region and the impingement region.
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| 28. |
- Du, Wei, et al.
(författare)
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Enhanced heat transfer in a labyrinth channels with ribs of different shape
- 2020
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Ingår i: International Journal of Numerical Methods for Heat and Fluid Flow. - 0961-5539. ; 30:2, s. 724-741
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this study is to enhance the thermal performance in the labyrinth channel by different ribs shape. The labyrinth channel is a relatively new cooling structure to decrease the temperature near the trailing region of gas turbine. Design/methodology/approach: Based on the geometric similarity, a simplified geometric model is used. The k − ω turbulence model is used to close the Navier–Stokes equations. Five rib shapes (one rectangular rib, two arched ribs and two trapezoid ribs) and five Reynolds numbers (10,000 to 50,000) are considered. The Nusselt number, flow structure and friction factor are analyzed. Findings: Nusselt number is tightly related to the rib shape in the labyrinth channel. The different shapes of the ribs result in different horseshoe vortex and wake region. In general, the arched rib brings the highest Nusselt number and friction factor. The Nusselt number is increased by 15.8 per cent compared to that of trapezoidal ribs. High Nusselt number is accompanied by the high friction factor in a labyrinth channels. The friction factor is increased by 64.6 per cent compared to rectangular ribs. However, the rib shape has a minor effect on the overall thermal performance. Practical implications: This study is useful to protect the trailing region of advanced gas turbine. Originality/value: This paper presents the flow structure and heat transfer characteristics in a labyrinth channel with different rib shapes.
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| 29. |
- Du, Wei, et al.
(författare)
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Heat transfer and flow structure in a detached latticework duct
- 2019
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Ingår i: Applied Thermal Engineering. - : Elsevier BV. - 1359-4311. ; 155, s. 24-39
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Tidskriftsartikel (refereegranskat)abstract
- A numerical method was used to study the effect of clearance and rotational number on the thermal performance in a detached latticework duct. The latticework duct, which had four-entry sub-channels, was located in a simplified rectangular channel. The crossing angle for each sub-channel was 45°. The numerical studies were conducted with various clearances (0–0.5) and various rotational numbers (0–0.5). The streamlines, wall shear stress and Nusselt number were analyzed. The results indicated that the detached latticework provided a small mechanical energy loss with considerable heat transfer enhancement. In the traditional latticework duct, the impingement, turn and helical flows dominated the flow structure. The impingement and helical flows brought high Nusselt numbers and high wall shear stress in the latticework duct. In the detached latticework, the leakage flow, which is induced by the clearance, also changed the flow structure and heat transfer significantly. As the clearance was increased, the leakage became strong while the impingement and helical flows became weak. In the rotational condition, the Coriolis force promoted the heat transfer on the suction side but weakened the heat transfer on the pressure side. In addition, the wall shear stress on the suction side and leakage flow were increased under high rotational number.
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| 30. |
- Du, Wei, et al.
(författare)
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Heat transfer and flow structure in a latticework duct with different sidewalls
- 2019
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Ingår i: Journal of Heat Transfer. - : ASME International. - 0022-1481 .- 1528-8943. ; 141:12
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Tidskriftsartikel (refereegranskat)abstract
- Heat transfer characteristics in a latticework duct with various sidewalls are numerically investigated. The crossing angle is 90 deg and the number of subchannels is eleven on both the pressure side and suction side for each latticework duct. The thickness of the ribs is 8 mm and the distance between adjacent ribs is 24 mm. The investigation is conducted for various Reynolds numbers (11,000 to 55,000) and six different sidewalls. Flow structure, pressure drop, and heat transfer characteristics are analyzed. Results revealed that the sidewall has significant effects on heat transfer and flow structure. The triangle-shaped sidewall provides the highest Nusselt number accompanied by the highest friction factor. The sidewall with a slot shows the lowest friction factor and Nusselt number. An increased slot width decreased the Nusselt number and friction factor simultaneously.
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| 31. |
- Du, Wei, et al.
(författare)
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Heat transfer and flow structure in a rotating duct with detached pin fins
- 2019
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Ingår i: Numerical Heat Transfer; Part A: Applications. - : Informa UK Limited. - 1040-7782 .- 1521-0634. ; 75:4, s. 217-241
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Tidskriftsartikel (refereegranskat)abstract
- The realizable k - ε turbulence model was used to calculate flow and heat transfer characteristics in a rotating rectangular duct with detached pin fins in staggered arrangement. Transverse and longitudinal spacings of the pin fins were S 1 = 2.5 D and S 2 = 2.5 D, respectively. Reynolds number was 7,000 and Rotation number (Ro) varied from 0 to 1 while the clearance ranged from 0 to 0.5. Streamlines, vortex structure, wall shear stresses and Nusselt numbers were obtained. Flow phenomenon at the pin fin rear side and a leakage vortex near the pin fin tip were observed. High Nusselt numbers appeared on leading side. The leakage vortex imposed high energy losses in the mainflow. The flow and heat transfer characteristics were associated with Ro number and clearance. Middle values of Ro and clearance induced highest Nusselt numbers on leading side. However, high Ro and small clearance gave highest Nusselt numbers on trailing side.
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| 32. |
- Du, Wei, et al.
(författare)
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Numerical investigation of flow field and heat transfer characteristics in a latticework duct with jet cooling structures
- 2020
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Ingår i: International Journal of Thermal Sciences. - : Elsevier BV. - 1290-0729. ; 158
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Tidskriftsartikel (refereegranskat)abstract
- Interaction effects of the latticework duct and jet cooling structures on the flow structure and heat transfer were numerically investigated. The latticework duct included eleven sub-channels both on the top wall and bottom wall. The crossing angle was set as 90°. The jet cooling structures had a curved target surface and seven jet nozzles. The jet cooling structures and latticework duct were connected by three different jet nozzle locations and two different jet nozzle shapes, respectively. In addition, six different mass flow ratios in the jet cooling structures were considered. Results showed that the flow field and heat transfer characteristics were sensitive to the jet nozzle location, shapes and mass flow ratios. When the mass flow ratio was increased in the jet cooling structure, the heat transfer was augmented in the jet cooling structure while it was decreased in the latticework duct. Using the jet nozzle near the turning region, the upward spiral flow and helical flow in the sub-channel of the latticework became weak, corresponding to a low Nusselt number in the latticework duct. However, the heat transfer in the jet cooling structure was enhanced. Furthermore, the circular jet nozzle provided high friction factor and Nusselt number both for the jet cooling structures and latticework duct.
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| 33. |
- Du, X. D., et al.
(författare)
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Multiscale Chirping Modes Driven by Thermal Ions in a Plasma with Reactor-Relevant Ion Temperature
- 2021
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 127:2
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Tidskriftsartikel (refereegranskat)abstract
- A thermal ion driven bursting instability with rapid frequency chirping, considered as an Alfvenic ion temperature gradient mode, has been observed in plasmas having reactor-relevant temperature in the DIII-D tokamak. The modes are excited over a wide spatial range from macroscopic device size to microturbulence size and the perturbation energy propagates across multiple spatial scales. The radial mode structure is able to expand from local to global in similar to 0.1 ms and it causes magnetic topology changes in the plasma edge, which can lead to a minor disruption event. Since the mode is typically observed in the high ion temperature greater than or similar to 10 keV and high-beta plasma regime, the manifestation of the mode in future reactors should be studied with development of mitigation strategies, if needed. This is the first observation of destabilization of the Alfven continuum caused by the compressibility of ions with reactor-relevant ion temperature.
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| 34. |
- Du, Yi-Jian, et al.
(författare)
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Expansion of all multitrace tree level EYM amplitudes
- 2017
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Ingår i: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :12
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we investigate the expansion of tree level multitrace Einstein-Yang-Mills (EYM) amplitudes. First, we propose two types of recursive expansions of tree level EYM amplitudes with an arbitrary number of gluons, gravitons and traces by those amplitudes with fewer traces or/and gravitons. Then we give many support evidence, including proofs using the Cachazo-He-Yuan (CHY) formula and Britto-Cachazo-Feng-Witten (BCFW) recursive relation. As a byproduct, two types of generalized BCJ relations for multitrace EYM are further proposed, which will be useful in the BCFW proof. After one applies the recursive expansions repeatedly, any multitrace EYM amplitudes can be given in the Kleiss-Kuijf (KK) basis of tree level color ordered Yang-Mills (YM) amplitudes. Thus the Bern-Carrasco-Johansson (BCJ) numerators, as the expansion coefficients, for all multitrace EYM amplitudes are naturally constructed.
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| 35. |
- Dubbaka Venu, Pradeep Reddy, 1982-, et al.
(författare)
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Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool
- 2008
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 319:5863, s. 611-613
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Tidskriftsartikel (refereegranskat)abstract
- In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activation are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of phosphatidylinositol 3-kinase (PI3K), the entire primordial follicle pool becomes activated. Subsequently, all primordial follicles become depleted in early adulthood, causing premature ovarian failure (POF). Our results show that the mammalian oocyte serves as the headquarters of programming of follicle activation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.
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| 36. |
- Gu, Song, et al.
(författare)
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Online Video Object Segmentation via Boundary-Constrained Low-Rank Sparse Representation
- 2019
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Ingår i: IEEE Access. - : Institute of Electrical and Electronics Engineers (IEEE). - 2169-3536. ; 7, s. 53520-53533
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Tidskriftsartikel (refereegranskat)abstract
- Graphcut-based algorithm is adopted in many video object segmentation systems because different terms can be probabilistically fused together in a framework. Constructing spatio-temporal coherences is an important stage in segmentation systems. However, many steps are involved when computing a key term with good discriminative power. If the cascade steps are adopted, the inaccurate output of the previous step will definitely affect the next step, leading to inaccurate segmentation. In this paper, a key term that is computed by a single framework referred to as boundary-constrained low-rank sparse representation (BCLRSR) is proposed to achieve the accurate segmentation. By treating the elements as linear combinations of dictionary templates, low-rank sparse optimization is adopted to achieve the spatio-temporal saliency. For adding the spatial information to the low-rank sparse model, a boundary constraint is adopted in the framework as a Laplacian regularization. A BCLRSR saliency is then obtained by the represented coefficients, which measure the similarity between the elements in the current frame and the ones in the dictionary. At last, the object is segmented by minimizing the energy function, which is formalized by the spatio-temporal coherences. The experiments on some public datasets show that our proposed algorithm outperforms the state-of-the-art methods.
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| 37. |
- Gupta, Deepesh Kumar, 1990-, et al.
(författare)
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Fate of bi-nucleated cells: the role of septin and Ras
- 2018
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Integrin-mediated adhesion is required to complete cytokinesis, and failure in the process can generate tetraploid cells, which are potentially oncogenic. The effect of cell detachment on the cytokinesis process and on the following cell cycle was analyzed in the non-transformed human fibroblast cell line BJ and in BJ cells expressing SV40 LT (BJ-LT) +/- an oncogenic Ras mutant. In non-adherent BJ and BJ-LT cells, ALIX could not be recruited to the midbody (MB) and cytokinetic abscission did not occur. Based on the results from several approaches, this block was concluded to be overcome in the detached BJ-LT-Ras cells. Non-adherent BJ and BJ-LT cells maintained the septin-associated intercellular bridge (ICB) formed by cleavage furrow ingression, for more than 24 hours. After re-adhesion to fibronectin most such cells divided by cytofission due to tension exerted on the narrow bridge, while a minor fraction of the cell population instead became bi-nucleated because of regression of the intercellular bridge. Adherent bi-nucleated BJ-LT cells progressed through the cell cycle and at mitosis they divided into two mono-nucleated (4N) cells, while adherent bi-nucleated BJ cells were arrested in the G1 phase and became senescent. Thus, p53-dependent mechanism(s) prevented the formation of tetraploid cells from non-transformed bi-nucleated cells. The two centrosomes in the adherent bi-nucleated cells rapidly fused, indicating that p53 was activated via the PIDDosome mechanism. The results show that several mechanisms contribute to prevent detached normal cells from generating tumor-causing tetraploid cells, and that expression of an activating Ras mutation can promote cytokinesis in detached tumor cells.
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| 38. |
- Gupta, Deepesh Kumar, et al.
(författare)
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Septin and Ras regulate cytokinetic abscission in detached cells
- 2019
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Ingår i: Cell Division. - : BMC. - 1747-1028. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Integrin-mediated adhesion is normally required for cytokinetic abscission, and failure in the process can generate potentially oncogenic tetraploid cells. Here, detachment-induced formation of oncogenic tetraploid cells was analyzed in non-transformed human BJ fibroblasts and BJ expressing SV40LT (BJ-LT) +/- overactive HRas. Results In contrast to BJ and BJ-LT cells, non-adherent BJ-LT-Ras cells recruited ALIX and CHMP4B to the midbody and divided. In detached BJ and BJ-LT cells regression of the cytokinetic furrow was suppressed by intercellular bridge-associated septin; after re-adhesion these cells divided by cytofission, however, some cells became bi-nucleated because of septin reorganization and furrow regression. Adherent bi-nucleated BJ cells became senescent in G1 with p21 accumulation in the nucleus, apparently due to p53 activation since adherent bi-nucleated BJ-LT cells passed through next cell cycle and divided into mono-nucleated tetraploids; the two centrosomes present in bi-nucleated BJ cells fused after furrow regression, pointing to the PIDDosome pathway as a possible mechanism for the p53 activation. Conclusions Several mechanisms prevent detached normal cells from generating tumor-causing tetraploid cells unless they have a suppressed p53 response by viruses, mutation or inflammation. Importantly, activating Ras mutations promote colony growth of detached transformed cells by inducing anchorage-independent cytokinetic abscission in single cells.
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| 39. |
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| 40. |
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| 41. |
- Li, Chenglei, et al.
(författare)
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Room-temperature direct regeneration of spent LiFePO4 cathode using the external short circuit strategy
- 2023
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Ingår i: Next Sustainability. - : Elsevier. - 2949-8236.
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Tidskriftsartikel (refereegranskat)abstract
- Lithium iron phosphate batteries (LFP), widely used as power sources, are forecasted to reach the terawatt-hour scale, inevitably leading to battery waste and expediating the urgency for effective recycling processes for LFP. The modern recycling methodologies based on material recovery face significant economic, environmental, and energy consumption challenges. This research attempts to resolve these challenges by providing direct cathode regeneration based on the principles of an external short-circuit to replenish lithium lost in the spent cathode with lithiated materials (LiC6, Li metal). Given that most active lithium loss in the cathode is caused by the growth of the solid electrolyte interphase rather than structural damage, restoring the lost lithium can revitalize a spent cathode battery’s electrochemical performance to a near-original state. The lithium loss in LFP cathodes ranging from 20% to 80% was renewed by supplementing lithium. Relithiation of 10Ah commercial LFP spent cathode showed revitalized electrochemical performance. Compared to the modern recycling methods, direct cathode regeneration improves the economic benefits of recycling by 33%, decreases energy consumption by 48%, and reduces carbon emissions by 62%. Direct cathode regeneration provides a scaffold for the next generation of recycling methods to improve recycling efficiency while reducing their environmental footprint.
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| 42. |
- Li, Fei, et al.
(författare)
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Integration of FeOOH and Zeolitic Imidazolate Framework-Derived Nanoporous Carbon as an Efficient Electrocatalyst for Water Oxidation
- 2018
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Ingår i: Advanced Energy Materials. - : Wiley-VCH Verlagsgesellschaft. - 1614-6832 .- 1614-6840. ; 8:10
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Tidskriftsartikel (refereegranskat)abstract
- As a cost-effective catalyst for the oxygen evolution reaction (OER), the potential use of FeOOH is hindered by its intrinsic poor electron conductivity. Here, the significant enhancement of OER activity and long-term stability of electrodeposited FeOOH on zeolitic imidazolate framework-derived N-doped porous carbons (NPCs) are reported. In alkaline media, FeOOH/NPC supported on nickel foam as a 3D electrode delivers a current density of 100 mA cm(-2) at a small overpotential of 230 mV and exhibits a low Tafel slope of 33.8 mV dec(-1) as well as excellent durability, making it one of the most active OER catalysts. Such high performance is attributed to a combined effect of the excellent electron conductivity of NPC and the synergy between FeOOH and NiO derived from Ni substrate.
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| 43. |
- Li, Fei, et al.
(författare)
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Water Splitting via Decoupled Photocatalytic Water Oxidation and Electrochemical Proton Reduction Mediated by Electron-Coupled-Proton Buffer
- 2017
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Ingår i: Chemistry - An Asian Journal. - : WILEY-V C H VERLAG GMBH. - 1861-4728 .- 1861-471X. ; 12:20, s. 2666-2669
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Tidskriftsartikel (refereegranskat)abstract
- Water splitting mediated by electron-coupled-proton buffer (ECPB) provides an efficient way to avoid gas mixing by separating oxygen evolution from hydrogen evolution in space and time. Though electrochemical and photoelectrochemcial water oxidation have been incorporated in such a two-step water splitting system, alternative ways to reduce the cost and energy input for decoupling two half-reactions are desired. Herein, we show the feasibility of photocatalytic oxygen evolution in a powder system with BiVO4 as a photocatalyst and polyoxometalate H3PMo12O40 as an electron and proton acceptor. The resulting reaction mixture was allowed to be directly used for the subsequent hydrogen evolution with the reduced H3PMo12O40 as electron and proton donors. Our system exhibits excellent stability in repeated oxygen and hydrogen evolution, which brings considerable convenience to decoupled water splitting.
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| 44. |
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| 45. |
- Liu, Jian, et al.
(författare)
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Design of Full-Scale Endwall Film Cooling of a Turbine Vane
- 2020
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Ingår i: Journal of Heat Transfer. - : ASME International. - 0022-1481 .- 1528-8943. ; 142:2
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Tidskriftsartikel (refereegranskat)abstract
- Endwall film cooling is a significant cooling method to protect the endwall region and the junction region of endwall and a turbine vane, where usually a relatively high temperature load exists. This work aims to find the optimized arrangement of film cooling holes on the endwall and improve the film cooling in some difficult regions on the endwall, such as pressure side-endwall junction region. Several ideas for film cooling hole arrangement design are proposed, based on the pressure coefficient distribution, the streamline distribution, and the heat transfer coefficient (HTC) distribution, respectively. Four specified designs are built and compared. The results are obtained by numerical calculations with a well-validated turbulence model, the k-ω shear stress transport (SST) model. From this work, the designs based on the pressure coefficient distribution (designs 1 and 2) force the flow from the pressure side to the suction side (SS), especially in design 2, which adopts compound angle holes. The designs based on pressure coefficients have benefit in the cooling of the SS but give worse coolant coverage on the pressure side. In addition, designs 1 and 2 have little influence on the original pressure field. The design based on the streamline distributions (design 3) has larger coolant coverage on the endwall and provides good coolant coverage on the endwall and pressure side junction region. The design based on the HTC distribution provides large overall film cooling effectiveness on both the pressure side and the SS. More film cooling holes are placed on the high temperature regions, which is more effective in practice.
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| 46. |
- Liu, Jian, et al.
(författare)
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Endwall film cooling holes design upstream of the leading edge of a turbine vane
- 2021
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Ingår i: Numerical Heat Transfer; Part A: Applications. - : Informa UK Limited. - 1040-7782 .- 1521-0634. ; 79:3, s. 222-245
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Tidskriftsartikel (refereegranskat)abstract
- Endwall film cooling upstream of the leading edge (LE) of a vane presents a relatively complex flow phenomenon due to the horseshoe vortices (HVs) generated at the LE region. Upstream of the LE region, the coolant flow has difficulties to eject out. This research work focuses on controlling the jet holes coolant coverage upstream of the LE region. Compound angle holes in staggered arrangement are introduced and applied in the LE region to increase the coolant coverage. Six different arrangements of cooling holes are designed, with variations from one row or two rows arrangements, parallel or staggered arrangements, normal cylindrical holes or compound angle holes. Besides cooling holes with different shapes and arrangements, effect of the blowing ratio (BR) and turbulence intensity (TI) are also considered. The BR ranges from 1 to 3 and TI ranges from 1.3% to 15%. The calculated results show that the film cooling holes upstream of the LE of a vane have significant cooling effects on both the vane surfaces and the endwall. At small BRs, the film cooling effectiveness (η) on the endwall is considerable. When the BR is increased, the η on the vane surfaces is increased more quickly and becomes dominant. The coolant coverage in the vane-endwall junction region are not affected by the mainstream turbulence intensity and almost keep the same with the varied turbulence intensities. A single row of cylindrical holes (Case 1) and two rows of compound angle holes with staggered arrangement (Case 5) have relatively high overall averaged cooling effectiveness compared with other cases at different BRs. In addition, the high averaged cooling effectiveness on the endwall and vane surfaces by Case 5 is not affected by a change of the BRs.
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| 47. |
- Lu, Jian, et al.
(författare)
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Surplus energy utilization of spent lithium-ion batteries for high-profit organolithiums
- 2022
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Ingår i: Carbon Energy. - : John Wiley & Sons. - 2637-9368. ; 5:6
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Tidskriftsartikel (refereegranskat)abstract
- It is challenging to efficiently and economically recycle many lithium-ion batteries (LIBs) because of the low valuation of commodity metals and materials, such as LiFePO4. There are millions of tons of spent LIBs where the barrier to recycling is economical, and to make recycling more feasible, it is required that the value of the processed recycled material exceeds the value of raw commodity materials. The presented research illustrates improved profitability and economics for recycling spent LIBs by utilizing the surplus energy in lithiated graphite to drive the preparation of organolithiums to add value to the recycled lithium materials. This study methodology demonstrates that the surplus energy of lithiated graphite obtained from spent LIBs can be utilized to prepare high-value organolithiums, thereby significantly improving the economic profitability of LIB recycling. Organolithiums (R–O–Li and R–Li) were prepared using alkyl alcohol (R–OH) and alkyl bromide (R–Br) as substrates, where R includes varying hindered alkyl hydrocarbons. The organolithiums extracted from per kilogram of recycled LIBs can increase the economic value between $29.5 and $226.5 kg−1 cell. The value of the organolithiums is at least 5.4 times the total theoretical value of spent materials, improving the profitability of recycling LIBs over traditional pyrometallurgical ($0.86 kg−1 cell), hydrometallurgical ($1.00 kg−1 cell), and physical direct recycling methods ($5.40 kg−1 cell).
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| 48. |
- Ma, Tianqiong, et al.
(författare)
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Observation of Interpenetration Isomerism in Covalent Organic Frameworks
- 2018
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 140:22, s. 6763-6766
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Tidskriftsartikel (refereegranskat)abstract
- We report herein the first example of interpenetration isomerism in covalent organic frameworks (COFs). As a well-known three-dimensional (3D) COF, COF-300 was synthesized and characterized by the Yaghi group in 2009 as a 5-fold interpenetrated diamond structure (dia-cS topology). We found that adding an aging process prior to the reported synthetic procedure afforded the formation of an interpenetration isomer, dia-c7 COF-300. The 7-fold interpenetrated diamond structure of this new isomer was identified by powder Xray diffraction and rotation electron diffraction analyses. Furthermore, we proposed a universal formula to accurately determine the number of interpenetration degrees of dia-based COFs from only the unit cell parameters and the length of the organic linker. This work not only provides a novel example to the category of interpenetration isomerism but also provides new insights for the further development of 3D COFs.
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| 49. |
- Mahajan, Anubha, et al.
(författare)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Tidskriftsartikel (refereegranskat)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 50. |
- Pelaz, B, et al.
(författare)
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Diverse Applications of Nanomedicine
- 2017
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Ingår i: ACS nano. - : American Chemical Society (ACS). - 1936-086X .- 1936-0851. ; 11:3, s. 2313-2381
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Tidskriftsartikel (refereegranskat)
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