| 1. |
- Charles-Orszag, A, et al.
(författare)
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Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting
- 2018
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 4450-
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Tidskriftsartikel (refereegranskat)abstract
- The shape of cellular membranes is highly regulated by a set of conserved mechanisms that can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that we term ‘one-dimensional’ membrane wetting. We provide a theoretical model that describes the physical basis of one-dimensional wetting and show that this mechanism occurs in model membranes interacting with nanofibers, and in human cells interacting with extracellular matrix meshworks. We propose one-dimensional wetting as a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococci during infection.
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| 2. |
- Manriquez, V, et al.
(författare)
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Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 4547-
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Tidskriftsartikel (refereegranskat)abstract
- The human pathogenNeisseria meningitidiscan cause meningitis and fatal systemic disease. The bacteria colonize blood vessels and rapidly cause vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, we use a humanized mouse model to show that vascular colonization leads to the recruitment of neutrophils, which partially reduce bacterial burden and vascular damage. This partial effect is due to the ability of bacteria to colonize capillaries, venules and arterioles, as observed in human samples. In venules, potent neutrophil recruitment allows efficient bacterial phagocytosis. In contrast, in infected capillaries and arterioles, adhesion molecules such as E-Selectin are not expressed on the endothelium, and intravascular neutrophil recruitment is minimal. Our results indicate that the colonization of capillaries and arterioles byN. meningitidiscreates an intravascular niche that precludes the action of neutrophils, resulting in immune escape and progression of the infection.
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| 3. |
- Richte-Dahlfors, A, et al.
(författare)
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Tissue microbiology emerging
- 2012
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Ingår i: Current opinion in microbiology. - : Elsevier BV. - 1879-0364 .- 1369-5274. ; 15:1, s. 1-2
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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