| 1. |
- Barker, Roger A., et al.
(författare)
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Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease
- 2019
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 25, s. 1045-1053
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Tidskriftsartikel (refereegranskat)abstract
- Clinical studies of Parkinson’s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced dyskinesia. This led to a re-appraisal of the best way to do such trials, which resulted in a new European-Union-funded allograft trial with fetal dopamine cells across several centers in Europe. This new trial, TRANSEURO (NCT01898390), is an open-label study in which some individuals in a large observational cohort of patients with mild PD who were undergoing identical assessments were randomly selected to receive transplants of hfVM. The TRANSEURO trial is currently ongoing as researchers have completed both recruitment into a large multicenter observational study of younger onset early-stage PD and transplantation of hfVM in 11 patients. While completion of TRANSEURO is not expected until 2021, we feel that sharing the rationale for the design of TRANSEURO, along with the lessons we have learned along the way, can help inform researchers and facilitate planning of transplants of dopamine-producing cells derived from human pluripotent stem cells for future clinical trials.
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| 2. |
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| 3. |
- Kyösti, Petter, et al.
(författare)
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Simulation of industrial support systems in the context of functional products
- 2011
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Ingår i: Proceedings of the 19th AR2TS Advances in Risk and Reliability Technology Symposium. - Nottingham : University of Nottingham. ; , s. 275-288
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Konferensbidrag (refereegranskat)abstract
- Functional Products, consisting of hardware and service support systems owned by the supplier, are sold to customers with a guaranteed availability of the function. The availability achieved is dependent on the reliability of both hardware and the service support system. The reliability of the latter can be defined as its ability to provide the required maintenance services in a timely manner. This paper reports simulation of a service support system from an industrial case study in order to predict its reliability. To identify and develop a suitable case together with an industrial partner company, a number of phone meetings were held in order to explain the research question, interview knowledgeable people and plan on-site visits and interviews. A number of interviews face to face were carried out with the industrial partners, where the goal was to obtain enough information to be able to model the support system correctly. The research involved both qualitative information gathering and applied computer aided simulation. An improved model for simulating a service support system is developed that considers the context in which the maintenance procedures are performed within a Functional Product. A software implementation of the model, developed by the authors, is applied to simulate the case study service support system in various scenarios such as different personnel availability and number of systems supported. The results show how the modeling can be used to improve and predict the reliability of the service support system
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| 4. |
- Löfstrand, Magnus, 1974-, et al.
(författare)
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Modelling and simulation of functional product system availability and support costs
- 2012
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Ingår i: International Journal of Product Development. - Bucks, United Kingdom : InderScience Publishers. - 1477-9056 .- 1741-8178. ; 16:3-4, s. 304-325
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Functional products (FP), total offers or product service systems, that comprise of both hardware (HW) and support services (SS) sold as an integrated offering under an availability guarantee, are becoming increasing popular in industry. This paper addresses, through modelling and simulation, the challenge faced by suppliers in developing an integrated HW and SS design to produce an FP which meets contracted availability. A recently published framework specified how an integrated model hardware and service support system model could be used to obtain functional availability predictions and perform simulation driven functional product development. This paper presents the first example of an integrated functional product model. It uses fault tree, Petri net and discrete event simulation techniques to enable the prediction of functional product availability and support costs. Such predictions are used here to evaluate and compare different service support system designs.
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| 5. |
- Reed, Sean, et al.
(författare)
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A modelling language for maintenance task scheduling
- 2012
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Ingår i: 11th International Probabilistic Safety Assessment and Management Conference and the Annual European Safety and Reliability Conference 2012. - New York : Curran Associates, Inc.. - 9781622764365 ; , s. 201-211
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Konferensbidrag (refereegranskat)abstract
- This paper presents a modelling language for representing the details necessary to analyse and model the implementation of maintenance strategies for generic hardware. The maintenance strategy determines which, and when, restorations and inspections should take place whilst the scheduling of maintenance tasks implements these goals. The manner of maintenance strategy implementation therefore has important implications for maintenance cost and other performance metrics. Despite this, maintenance strategy optimisation models found in the literature lack detailed maintenance implementation models, which may lead to inaccurate and misleading results. The presented modelling language permits the representation of all common constraints and outcomes between maintenance tasks that influence task schedules. In doing so, it provides a platform for the future development of maintenance task schedule modelling, planning and decision support tools. The modelling language is demonstrated through application to part of a car braking system
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| 6. |
- Reed, Sean, 1982-, et al.
(författare)
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Improved efficiency in the analysis of phased mission systems with multiple failure mode components
- 2011
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Ingår i: IEEE Transactions on Reliability. - : IEEE. - 0018-9529 .- 1558-1721. ; 60:1, s. 70-79
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Tidskriftsartikel (refereegranskat)abstract
- Systems often operate in phased missions where their reliability structure varies over a set of consecutive time periods, known as phases. The reliability of a phased mission is defined as the probability that all phases in the mission are completed without failure. While the Binary Decision Diagram (BDD) method has been shown to be the most efficient solution for measuring the reliability of phased missions with non-repairable components with mutually exclusive failure modes, the existing BDD based methods are still unable to analyze large systems without considerable computational expense. This paper introduces a new BDD based method that is shown to provide improved efficiency and accuracy in the repeat analysis of this type of phased mission.
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| 7. |
- Reed, Sean, et al.
(författare)
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Modelling service support system reliability
- 2011
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Ingår i: First IFAC Workshop on Advanced Maintenance Engineering, Services and Technology (2010). - Red Hook, NY : IFAC, International Federation of Automatic Control. - 9783902661784 ; , s. 56-61
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Konferensbidrag (refereegranskat)
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| 8. |
- Reed, Sean, et al.
(författare)
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Modelling service support system reliability
- 2010
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Functional Products, where the customer pays for the function and availability of a product instead of the product itself, are increasingly popular in capital intensive industries such as aerospace. Such products are integrated systems involving the combination of hardware and service support systems. The reliability prediction and optimisation of the service system that supports the hardware availability is essential to the feasibility of the product. These systems consist of maintenance procedures and resource provisions. Simulation based techniques are presented in this paper to analyse the reliability of support systems and their application is demonstrated through a simple example.
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| 9. |
- Roussakis, Andreas Antonios, et al.
(författare)
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Parkinson’s disease laterality : a 11C-PE2I PET imaging study
- 2020
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Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459.
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Tidskriftsartikel (refereegranskat)abstract
- Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.
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