| 1. |
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| 2. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 3. |
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| 4. |
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| 5. |
- Caprioglio, C, et al.
(författare)
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Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline
- 2023
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Ingår i: JAMA network open. - : American Medical Association (AMA). - 2574-3805. ; 6:1, s. e2250921-
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Tidskriftsartikel (refereegranskat)abstract
- Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+ undergo amyloid-positron emission tomography (PET) as part of research studies and frequently wish to know their amyloid status; however, the disclosure of a positive amyloid-PET result might have psychological risks.ObjectiveTo assess the psychological outcomes of the amyloid-PET result disclosure in individuals with SCD+ and explore which variables are associated with a safer disclosure in individuals who are amyloid positive.Design, Setting, and ParticipantsThis prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). The setting was 5 European memory clinics, and participants included patients with SCD+ who underwent amyloid-PET. Statistical analysis was performed from July to October 2022.ExposuresDisclosure of amyloid-PET result.Main Outcomes and MeasuresPsychological outcomes were defined as (1) disclosure related distress, assessed using the Impact of Event Scale–Revised (IES-R; scores of at least 33 indicate probable presence of posttraumatic stress disorder [PTSD]); and (2) anxiety and depression, assessed using the Hospital Anxiety and Depression scale (HADS; scores of at least 15 indicate probable presence of severe mood disorder symptoms).ResultsAfter disclosure, 27 patients with amyloid-positive SCD+ (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median [IQR] education: 15 [13 to 17] years, median [IQR] Mini-Mental State Examination [MMSE] score, 29 [28 to 30]) had higher median (IQR) IES-R total score (10 [2 to 14] vs 0 [0 to 2]; P < .001), IES-R avoidance (0.00 [0.00 to 0.69] vs 0.00 [0.00 to 0.00]; P < .001), IES-R intrusions (0.50 [0.13 to 0.75] vs 0.00 [0.00 to 0.25]; P < .001), and IES-R hyperarousal (0.33 [0.00 to 0.67] vs 0.00 [0.00 to 0.00]; P < .001) scores than the 78 patients who were amyloid-negative (median [IQR], age, 67 [64 to 74] years, 45 men [58%], median [IQR] education: 15 [12 to 17] years, median [IQR] MMSE score: 29 [28 to 30]). There were no observed differences between amyloid-positive and amyloid-negative patients in the median (IQR) HADS Anxiety (–1.0 [–3.0 to 1.8] vs –2.0 [–4.8 to 1.0]; P = .06) and Depression (–1.0 [–2.0 to 0.0] vs –1.0 [–3.0 to 0.0]; P = .46) deltas (score after disclosure – scores at baseline). In patients with amyloid-positive SCD+, despite the small sample size, higher education was associated with lower disclosure-related distress (ρ = –0.43; P = .02) whereas the presence of study partner was associated with higher disclosure-related distress (W = 7.5; P = .03). No participants with amyloid-positive SCD+ showed probable presence of PTSD or severe anxiety or depression symptoms at follow-up.Conclusions and RelevanceThe disclosure of a positive amyloid-PET result to patients with SCD+ was associated with a bigger psychological change, yet such change did not reach the threshold for clinical concern.
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| 6. |
- Caprioglio, C, et al.
(författare)
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Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline
- 2023
-
Ingår i: JAMA network open. - : American Medical Association (AMA). - 2574-3805. ; 6:1, s. e2250921-
-
Tidskriftsartikel (refereegranskat)abstract
- Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+ undergo amyloid-positron emission tomography (PET) as part of research studies and frequently wish to know their amyloid status; however, the disclosure of a positive amyloid-PET result might have psychological risks.ObjectiveTo assess the psychological outcomes of the amyloid-PET result disclosure in individuals with SCD+ and explore which variables are associated with a safer disclosure in individuals who are amyloid positive.Design, Setting, and ParticipantsThis prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). The setting was 5 European memory clinics, and participants included patients with SCD+ who underwent amyloid-PET. Statistical analysis was performed from July to October 2022.ExposuresDisclosure of amyloid-PET result.Main Outcomes and MeasuresPsychological outcomes were defined as (1) disclosure related distress, assessed using the Impact of Event Scale–Revised (IES-R; scores of at least 33 indicate probable presence of posttraumatic stress disorder [PTSD]); and (2) anxiety and depression, assessed using the Hospital Anxiety and Depression scale (HADS; scores of at least 15 indicate probable presence of severe mood disorder symptoms).ResultsAfter disclosure, 27 patients with amyloid-positive SCD+ (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median [IQR] education: 15 [13 to 17] years, median [IQR] Mini-Mental State Examination [MMSE] score, 29 [28 to 30]) had higher median (IQR) IES-R total score (10 [2 to 14] vs 0 [0 to 2]; P < .001), IES-R avoidance (0.00 [0.00 to 0.69] vs 0.00 [0.00 to 0.00]; P < .001), IES-R intrusions (0.50 [0.13 to 0.75] vs 0.00 [0.00 to 0.25]; P < .001), and IES-R hyperarousal (0.33 [0.00 to 0.67] vs 0.00 [0.00 to 0.00]; P < .001) scores than the 78 patients who were amyloid-negative (median [IQR], age, 67 [64 to 74] years, 45 men [58%], median [IQR] education: 15 [12 to 17] years, median [IQR] MMSE score: 29 [28 to 30]). There were no observed differences between amyloid-positive and amyloid-negative patients in the median (IQR) HADS Anxiety (–1.0 [–3.0 to 1.8] vs –2.0 [–4.8 to 1.0]; P = .06) and Depression (–1.0 [–2.0 to 0.0] vs –1.0 [–3.0 to 0.0]; P = .46) deltas (score after disclosure – scores at baseline). In patients with amyloid-positive SCD+, despite the small sample size, higher education was associated with lower disclosure-related distress (ρ = –0.43; P = .02) whereas the presence of study partner was associated with higher disclosure-related distress (W = 7.5; P = .03). No participants with amyloid-positive SCD+ showed probable presence of PTSD or severe anxiety or depression symptoms at follow-up.Conclusions and RelevanceThe disclosure of a positive amyloid-PET result to patients with SCD+ was associated with a bigger psychological change, yet such change did not reach the threshold for clinical concern.
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| 7. |
- Scott, G., et al.
(författare)
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Amyloid pathology and axonal injury after brain trauma
- 2016
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Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 86:9, s. 821-828
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Tidskriftsartikel (refereegranskat)abstract
- Objective:To image -amyloid (A) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and A are correlated, and compare the spatial distribution of A to Alzheimer disease (AD).Methods:Patients 11 months to 17 years after moderate-severe TBI underwent C-11-Pittsburgh compound B (C-11-PiB)-PET, structural and diffusion MRI, and neuropsychological examination. Healthy aged controls and patients with AD underwent PET and structural MRI. Binding potential (BPND) images of C-11-PiB, which index A plaque density, were computed using an automatic reference region extraction procedure. Voxelwise and regional differences in BPND were assessed. In TBI, a measure of white matter integrity, fractional anisotropy, was estimated and correlated with C-11-PiB BP(ND.)Results:Twenty-eight participants (9 with TBI, 9 controls, 10 with AD) were assessed. Increased C-11-PiB BPND was found in TBI vs controls in the posterior cingulate cortex and cerebellum. Binding in the posterior cingulate cortex increased with decreasing fractional anisotropy of associated white matter tracts and increased with time since injury. Compared to AD, binding after TBI was lower in neocortical regions but increased in the cerebellum.Conclusions:Increased A burden was observed in TBI. The distribution overlaps with, but is distinct from, that of AD. This suggests a mechanistic link between TBI and the development of neuropathologic features of dementia, which may relate to axonal damage produced by the injury.
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| 8. |
- Zamora, Juan Carlos, et al.
(författare)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Tidskriftsartikel (refereegranskat)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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| 9. |
- Manzano-Nunez, Ramiro, et al.
(författare)
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A meta-analysis of the incidence of complications associated with groin access after the use of resuscitative endovascular balloon occlusion of the aorta in trauma patients.
- 2018
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Ingår i: Journal of Trauma and Acute Care Surgery. - : Lippincott Williams & Wilkins. - 2163-0755 .- 2163-0763. ; 85:3, s. 626-634
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND: Serious complications related to groin access have been reported with the use of resuscitative endovascular balloon occlusion of the aorta (REBOA). We performed a systematic review and meta-analysis to estimate the incidence of complications related to groin access from the use of REBOA in adult trauma patients.METHODS: We identified articles in MEDLINE and EMBASE. We reviewed all studies that involved adult trauma patients that underwent the placement of a REBOA and included only those that reported the incidence of complications related to groin access. A meta-analysis of proportions was performed RESULTS: We 13 studies with a total of 424 patients. REBOA was inserted most commonly by trauma surgeons or emergency room physicians. Information regarding puncture technique was reported in 12 studies and was available for a total of 414 patients. Percutaneous access and surgical cutdown were performed in 304 (73.4%) and 110 (26.5%) patients respectively. Overall, complications related to groin access occurred in 5.6% of patients (n=24/424). Lower limb amputation was required in 2.1% of patients (9/424), of which three cases (3/424 [0.7%]) were directly related to the vascular puncture from the REBOA insertion. A meta-analysis which used the logit transformation showed a 5% (95% CI 3%-9%) incidence of complications without significant heterogeneity (LR test: χ2 = 0.73, p=0.2, Tau-square=0.2). In a second meta-analysis, we used the Freeman-Turkey double arcsine transformation and found an incidence of complications of 4% (95% CI 2%-7%) with low heterogeneity (I2 = 16.3%).CONCLUSION: We found that the incidence of complications related to groin access was of four to five percent based on a meta-analysis of 13 studies published worldwide. Currently, there are no benchmarks or quality measures as a reference to compare, and thus, further work is required to identify these benchmarks and improve the practice of REBOA in trauma surgery.LEVEL OF EVIDENCE: Systematic Review and Meta-analysis, Level III.
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| 10. |
- Smedby, Karin E., et al.
(författare)
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GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma
- 2011
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 7:4, s. e1001378-
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Tidskriftsartikel (refereegranskat)abstract
- Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (ORcombined = 0.64, P-combined= 2x10(-21)) located 962 bp away from rs10484561 (r(2)< 0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012: ORadjusted = 0.70, P-adjusted= 4x10(-12); rs10484561: ORadjusted = 1.64, P-adjusted= 5x10(-15)). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (ORcombined = 1.36, P-combined = 1.4x10(-7)). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL.
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| 11. |
- Alagaratnam, J., et al.
(författare)
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Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis
- 2021
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Ingår i: Bmj Neurology Open. - : BMJ. - 2632-6140. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Objective To assess the overall pooled correlation coefficient estimate between cerebrospinal fluid (CSF) and blood neurofilament light (NfL) protein. Methods We searched Medline, Embase and Web of Science for published articles, from their inception to 9 July 2019, according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies reporting the correlation between CSF and blood NfL in humans were included. We conducted a random-effects meta-analysis to calculate the overall pooled correlation coefficient estimate, accounting for correlation technique and assay used. Heterogeneity was assessed using the I-2 statistic test. In sensitivity analyses, we calculated the pooled correlation coefficient estimate according to blood NfL assay: single-molecule array digital immunoassay (Simoa), electrochemiluminescence (ECL) assay or ELISA. Results Data were extracted from 36 articles, including 3961 paired CSF and blood NfL samples. Overall, 26/36 studies measured blood NfL using Simoa, 8/36 ECL, 1/36 ELISA and 1 study reported all three assay results. The overall meta-analysis demonstrated that the pooled correlation coefficient estimate for CSF and blood NfL was r=0.72. Heterogeneity was significant: I-2=83%, p<0.01. In sensitivity analyses, the pooled correlation coefficient was similar for studies measuring blood NfL using Simoa and ECL (r=0.69 and r=0.68, respectively) but weaker for ELISA (r=0.35). Conclusion Moderate correlations are demonstrated between CSF and blood NfL, especially when blood NfL was measured using Simoa and ECL. Given its high analytical sensitivity, Simoa is the preferred assay for measuring NfL, especially at low or physiological concentrations, and this meta-analysis supports its use as the current most advanced surrogate measure of CSF NfL. PROSPERO registration number CRD42019140469
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| 12. |
- Binotto, Alécio P. D., et al.
(författare)
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Dynamic Self-Rescheduling of Tasks over a Heterogeneous Platform
- 2008
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Ingår i: Proceedings of the 2008 International Conference on Reconfigurable Computing and FPGAs. - Los Alamitos, Calif. : IEEE Computer Society. - 9780769534749 ; , s. 253-258
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Konferensbidrag (refereegranskat)abstract
- Modern applications require powerful high-performance platforms to deal with many different algorithms that make use of massive calculations. At the same time, low-cost and high-performance specific hardware (e.g., GPU, PPU) are rising and the CPUs turned to multiple cores, characterizing together an interesting and powerful heterogeneous execution platform. Therefore, self-adaptive computing is a potential paradigm for those scenarios as it can provide flexibility to explore the computational resources on heterogeneous cluster attached to a high-performance computer system platform. As the first step towards a run-time reschedule load-balancing framework targeting that kind of platform, application time requirements and its crosscutting behavior play an important role for task allocation decisions. This paper presents a strategy for self-reallocation of specific tasks, including dynamic created ones, using aspect-oriented paradigms to address non-functional application timing constraints in the design phase. Additionally, as a case study, a special attention on Radar Image Processing will be given in the context of a surveillance system based on Unmanned Aerial Vehicles (UAV).
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| 13. |
- Binotto, A.P.D., et al.
(författare)
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Real-time task reconfiguration support applied to an UAV-based surveillance system
- 2008
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Ingår i: 2008 International Multiconference on Computer Science and Information Technology (Imcsit). - Piscataway, N.J. : IEEE Press. - 9788360810149 ; , s. 581-588
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Konferensbidrag (refereegranskat)abstract
- Modern surveillance systems, such as those based on the use of Unmanned Aerial Vehicles, require powerful high- performance platforms to deal with many different algorithms that make use of massive calculations. At the same time, low- cost and high-performance specific hardware (e.g., GPU, PPU) are rising and the CPUs turned to multiple cores, characteriz- ing together an interesting and powerful heterogeneous execu- tion platform. Therefore, reconfigurable computing is a poten- tial paradigm for those scenarios as it can provide flexibility to explore the computational resources on heterogeneous cluster attached to a high-performance computer system platform. As the first step towards a run-time reconfigurable workload bal- ancing framework targeting that kind of platform, application time requirements and its crosscutting behavior play an impor- tant role for task allocation decisions. This paper presents a strategy to reallocate specific tasks in a surveillance system composed by a fleet of Unmanned Aerial Vehicles using aspect- oriented paradigms in order to address non-functional applica- tion timing constraints in the design phase. An aspect support from a framework called DERAF is used to support reconfigu- ration requirements and provide the resource information needed by the reconfigurable load-balancing strategy. Finally, for the case study, a special attention on Radar Image Process- ing will be given.
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| 14. |
- Binotto, Alécio P. D., et al.
(författare)
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Towards task dynamic reconfiguration over asymmetric computing platforms for UAVs surveillance systems
- 2009
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Ingår i: Scalable computing. - Timisoara : Universitatea de Vest din Timisoara / West University of Timisoara. - 1895-1767. ; 10:3, s. 277-289
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Tidskriftsartikel (refereegranskat)abstract
- High-performance platforms are required by modern applications that make use of massive calculations. Actually, low-cost and high-performance specific hardware (e.g. GPU) can be a good alternative along with CPUs, which turned to multiple cores, forming powerful heterogeneous desktop execution platforms. Therefore, self-adaptive computing is a promising paradigm as it can provide flexibility to explore different computing resources, on which heterogeneous cluster can be created to improve performance on different execution scenarios. One approach is to explore run-time tasks migration among node's hardware towards an optimal system load-balancing aiming at performance gains. This way, time requirements and its crosscutting behavior play an important role for task (re)allocation decisions. This paper presents a self-rescheduling task strategy that makes use of aspect-oriented paradigms to address non-functional application timing constraints from earlier design phases. A case study exploring Radar Image Processing tasks is presented to demonstrate the proposed approach. Simulations results for this case study are provided in the context of a surveillance system based on Unmanned Aerial Vehicles (UAVs). © 2009 SCPE.
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| 15. |
- Boeira, Felipe, 1992-, et al.
(författare)
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Effects of Colluding Sybil Nodes in Message Falsification Attacks for Vehicular Platooning
- 2017
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Ingår i: 2017 IEEE Vehicular Networking Conference (VNC). - : IEEE. - 9781538609866 - 9781538609859 - 9781538609873
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Konferensbidrag (refereegranskat)abstract
- This paper studies the impact of vulnerabilities associated with the Sybil attack (through falsification of multiple identities) and message falsification in vehicular platooning. Platooning employs Inter-Vehicular Communication (IVC) to control a group of vehicles. It uses broadcast information such as acceleration, position, and velocity to operate a longitudinal control law. Cooperation among vehicles allows platoons to reduce fuel consumption and risks associated with driver mistakes. In spite of these benefits, the use of network communication to control vehicles exposes a relevant attack surface that can be exploited by malicious actors. To carry out this study, we evaluate five scenarios to quantify the potential impact of such attacks, identifying how platoons behave under varying Sybil attack conditions and what are the associated safety risks. This research also presents the use of location hijacking attack. In this attack, innocent vehicles that are not part of a platoon are used as a way to create trust bond between the false identities and the physical vehicles. We demonstrate that the ability to create false identities increases the effectiveness of message falsification attacks by making them easier to deploy and harder to detect in time.
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- de Erausquin, Gabriel A, et al.
(författare)
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Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.
- 2022
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Ingår i: Alzheimer's & dementia (New York, N. Y.). - : Wiley. - 2352-8737. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term.This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions.Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe.The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection.The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility.The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease.We provide a framework for current and future studies to be carried out within the Consortium. and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic.The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations.
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| 20. |
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| 21. |
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| 22. |
- Marques Marinho, Marco Antonio, 1986-, et al.
(författare)
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Spherical Wave Array Based Positioning for Vehicular Scenarios
- 2020
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Ingår i: IEEE Access. - Piscataway, N.J. : IEEE. - 2169-3536. ; 8, s. 110073-110081
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Tidskriftsartikel (refereegranskat)abstract
- Smart vehicles are emerging as a possible solution for multiple concerns in road traffic, such as mobility and safety. This work presents radio localization methods based on simultaneous direction of arrival (DOA), time-delay, and range estimation using the SAGE algorithm. The proposed methods do not rely on external sources of information, such as global navigation satellite systems (GNSS). The proposed methods take advantage of signals of opportunity and do not require the transmission of location-specific signals; therefore, they do not increase the network load. A set of simulations using synthetic and measured data is provided to validate the proposed methods, and the results show that it is possible to achieve accuracy down to decimeter and centimeter-level. © 2013 IEEE.
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| 23. |
- Motter, P., et al.
(författare)
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Practical issues in Wireless Sensor Network localization systems using received signal strength indication
- 2011
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Ingår i: Sensors Applications Symposium (SAS), 2011 IEEE. - New York : IEEE Computer Society. - 9781424480630 ; , s. 227-232
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The emergence of Wireless Sensor Networks brought many benefits in different application domains such as collaborative tasks, lower costs, equipment's autonomy and higher tolerance to failures. These advantages made the number of applications that use this kind of network grow in the past few years. Meanwhile, the possibility of employing these systems to trace the movement of an object, which can be part of the network itself, is of great utility. The present work aims at the study and development of a localization system of mobile nodes for Wireless Sensor Networks. Different methods to obtain the distances between network nodes are studied and received signal strength algorithms are developed to synthesize the data and to show the location of the nodes. Finally, simulations and experiments are presented in order to analyze the viability of the developed proposal.
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| 24. |
- Pignaton de Freitas, Edison, et al.
(författare)
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Dynamic Reconfigurable Task Schedule Support towards a Reflective Middleware for Sensor Network
- 2008
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Ingår i: Proceedings of the 2008 International Symposium on Parallel and Distributed Processing with Applications. - Los Alamitos, Calif. : IEEE Computer Society. - 9780769534718 ; , s. 886-891
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Konferensbidrag (refereegranskat)abstract
- Sensor networks are being applied in several emerging sophisticated applications due to the use of powerful and high-quality sensor nodes, such as radars and visible light cameras. However, these nodes need additional features to optimally benefit from heterogeneous modern computing platforms. Therefore, reconfigurable computing is a potential paradigm for those scenarios as it can provide flexibility to explore the computational resources on that kind of high performance computing system. This paper presents a reconfigurable sensor node allocation support, based on application requirements, provided by a middleware focused on heterogeneous sensor networks. In order to address this concern, an aspect-orientation paradigm and intelligent agents approach is proposed followed by an UAV case study.
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| 25. |
- Pignaton de Freitas, Edison, et al.
(författare)
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Dynamic Tasks' Reconfiguration for UAV System using Aspect Orientation
- 2008
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Ingår i: International Symposium on Parallel and Distributed Processing with Applications, 2008. ISPA '08. - Piscataway, N.J. : IEEE Press. - 9780769534718 ; , s. 292-300
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Konferensbidrag (refereegranskat)abstract
- Many modern applications require high-performance platforms to deal with a variety of algorithms requiring massive calculations. Moreover, low-cost powerful hardware (e.g., GPU, PPU) and CPUs with multiple cores have become abundant, and can be combined in heterogeneous architectures. To cope with this, reconfigurable computing is a potential paradigm as it can provide flexibility to explore the computational resources on hybrid and multi-core desktop architectures. The workload can optimally be (re)distributed over heterogeneous cores along the lifecycle of an application, aiming for best performance. As the first step towards a run-time reconfigurable load-balancing framework, application requirements and crosscutting concerns related to timing play an important role for task allocation decisions. In this paper, we present the use of aspect-oriented paradigms to address non-functional application timing constraints in the design phase. The DERAF aspects’ framework is extended to support reconfiguration requirements; and a strategy for load-balancing is described. In addition, we present preliminary evaluation using an Unmanned Aerial Vehicle (UAV) based Surveillance System as case study.
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| 26. |
- Saar de Moraes, Rodrigo, et al.
(författare)
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Experimental analysis of heuristic solutions for the moving target traveling salesman problem applied to a moving targets monitoring system
- 2019
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Ingår i: Expert systems with applications. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0957-4174 .- 1873-6793. ; 136, s. 392-409
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Tidskriftsartikel (refereegranskat)abstract
- The Traveling Salesman Problem (TSP) is an important problem in computer science which consists in finding a path linking a set of cities so that each of then can be visited once, before the traveler comes back to the starting point. This is highly relevant because several real world problems can be mapped to it. A special case of TSP is the one in which the cities (the points to be visited) are not static as the cities, but mobile, changing their positions as the time passes. This variation is known as Moving Target TSP (MT-TSP). Emerging systems for crowd monitoring and control based on unmanned aerial vehicles (UAVs) can be mapped to this variation of the TSP problem, as a number of persons (targets) in the crowd can be assigned to be monitored by a given number of UAVs, which by their turn divide the targets among them. These target persons have to be visited from time to time, in a similar way to the cities in the traditional TSP. Aiming at finding a suitable solution for this type of crowd monitoring application, and considering the fact that exact solutions are too complex to perform in a reasonable time, this work explores and compares different heuristic methods for the intended solution. The performed experiments showed that the Genetic Algorithms present the best performance in finding acceptable solutions for the problem in restricted time and processing power situations, performing better compared to Ant Colony Optimization and Simulated Annealing Algorithms. (C) 2019 Published by Elsevier Ltd.
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| 27. |
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