| 1. |
- Jiang, X., et al.
(författare)
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Shared heritability and functional enrichment across six solid cancers
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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| 11. |
- Cozen, W., et al.
(författare)
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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
- 2014
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 3856-
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Tidskriftsartikel (refereegranskat)abstract
- Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
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| 12. |
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| 13. |
- Ilegems, E., et al.
(författare)
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Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- The pancreatic islet of Langerhans is composed of endocrine cells producing and releasing hormones from secretory granules in response to various stimuli for maintenance of blood glucose homeostasis. In order to adapt to a variation in functional demands, these islets are capable of modulating their hormone secretion by increasing the number of endocrine cells as well as the functional response of individual cells. A failure in adaptive mechanisms will lead to inadequate blood glucose regulation and thereby to the development of diabetes. It is therefore necessary to develop tools for the assessment of both pancreatic islet mass and function, with the aim of understanding cellular regulatory mechanisms and factors guiding islet plasticity. Although most of the existing techniques rely on the use of artificial indicators, we present an imaging methodology based on intrinsic optical properties originating from mature insulin secretory granules within endocrine cells that reveals both pancreatic islet mass and function. We demonstrate the advantage of using this imaging strategy by monitoring in vivo scattering signal from pancreatic islets engrafted into the anterior chamber of the mouse eye, and how this versatile and noninvasive methodology permits the characterization of islet morphology and plasticity as well as hormone secretory status.
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| 14. |
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| 15. |
- Karlsson, P, et al.
(författare)
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Low-Density Cellulose-Based Foams: Preparation, Characterization and Biodegradation
- 2023
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Ingår i: Book of Abstracts EPNOE 2023. - : Graz University of Technology. ; , s. 345-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The demands for alternatives to fossil-based materials for the packaging and building sector is rapidly increasing as new regulations and laws are set. The usage of such materials in low- density applications is increasingly questioned since only a small amount is recycled and a large part ends up in the environment where it has a very long decomposition time and contributes to the emergence of microplastics in our marine eco systems. Alternatives to fossil- based low-density materials has been demonstrated using e.g., starch [1] and cellulose [2] as raw materials. However, challenges remain regarding the process parameters and properties such as strength and water integrity. To fulfil these properties requested by the specification owners, understanding is needed regarding which tools that are available for incorporating wet-integrity and hydrophobicity without causing the wet foam to collapse during the foaming or drying process. It is also of highest importance to have an early understanding of how such materials can be recycled and/or bio-degraded to fit a circular economy. In this study two different cross-linkers and two different types of hydrophobisers are used to obtain a wet stable and a water repelling low-density material. The wet foams are characterized by measuring the foamability and foam stability and the dry foams are characterized in terms of structure, porosity and degradability. Two demonstrators have been produced based on the most promising material composition and the up-scaling processes of the developed foaming technology to both batch-wise and continuous fabrication of composite foams is underway. Finally, a biodegradation study was conducted and evaluated.[1] S. Chaireh, P. Ngasatool, and K. Kaewtatip, “Novel composite foam made from starch and water hyacinth with beeswax coating for food packaging applications,” Int. J. Biol. Macromol., vol. 165, pp. 1382–1391, 2020[2] C. Qin, M. Yao, Y. Liu, Y. Yang, Y. Zong, and H. Zhao, “MFC/NFC-based foam/aerogel for production of porous materials: Preparation, properties and applications,” Materials (Basel)., vol. 13, no. 23, pp. 1–21, 2020
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| 16. |
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| 17. |
- Sundqvist, Bertil, et al.
(författare)
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Physical properties of pressure polymerized C60
- 1996
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Ingår i: Proceedings of the Symposium on Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials. - Pennington, NJ : Electrochemical Society, Incorporated. - 1566771625 ; , s. 1014-1028
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Konferensbidrag (refereegranskat)
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| 18. |
- Woitowich, N. C., et al.
(författare)
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Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome
- 2018
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Ingår i: Iucrj. - : International Union of Crystallography (IUCr). - 2052-2525. ; 5:Part 5, s. 619-634
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Tidskriftsartikel (refereegranskat)abstract
- Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states denoted Pr and Pfr with distinct absorption spectra in the red and far-red. They have recently been engineered as enzymatic photoswitches for fluorescent-marker applications in non-invasive tissue imaging of mammals. This article presents cryo- and room-temperature crystal structures of the unusual phytochrome from the non-photosynthetic myxobacterium Stigmatella aurantiaca (SaBphP1) and reveals its role in the fruitingbody formation of this photomorphogenic bacterium. SaBphP1 lacks a conserved histidine (His) in the chromophore-binding domain that stabilizes the Pr state in the classical BphPs. Instead it contains a threonine (Thr), a feature that is restricted to several myxobacterial phytochromes and is not evolutionarily understood. SaBphP1 structures of the chromophore binding domain (CBD) and the complete photosensory core module (PCM) in wild-type and Thr-to-His mutant forms reveal details of the molecular mechanism of the Pr/Pfr transition associated with the physiological response of this myxobacterium to red light. Specifically, key structural differences in the CBD and PCM between the wild-type and the Thr-to-His mutant involve essential chromophore contacts with proximal amino acids, and point to how the photosignal is transduced through the rest of the protein, impacting the essential enzymatic activity in the photomorphogenic response of this myxobacterium.
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| 19. |
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| 20. |
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| 21. |
- Chen, Zhishan, et al.
(författare)
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Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
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| 22. |
- Ebersole, Charles R., et al.
(författare)
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Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
- 2020
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Ingår i: Advances in Methods and Practices in Psychological Science. - : Sage. - 2515-2467 .- 2515-2459. ; 3:3, s. 309-331
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Tidskriftsartikel (refereegranskat)abstract
- Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3-9; median total sample = 1,279.5, range = 276-3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Delta r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00-.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19-.50).
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| 23. |
- Edlund, Petra, et al.
(författare)
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The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain. Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on these conformational changes. Here we report the room temperature crystal structure of the chromophore-binding domains of the Deinococcus radiodurans phytochrome at 2.1 angstrom resolution. The structure was obtained by serial femtosecond X-ray crystallography from microcrystals at an X-ray free electron laser. We find overall good agreement compared to a crystal structure at 1.35 angstrom resolution derived from conventional crystallography at cryogenic temperatures, which we also report here. The thioether linkage between chromophore and protein is subject to positional ambiguity at the synchrotron, but is fully resolved with SFX. The study paves the way for time-resolved structural investigations of the phytochrome photocycle with time-resolved SFX.
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| 24. |
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| 25. |
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| 26. |
- Laure, Erwin, et al.
(författare)
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Programming the Grid using gLite
- 2006
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Ingår i: Computational Methods in Science and Technology. - 1505-0602. ; 12:1, s. 33-45
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The past few years have seen the creation of the first production level Grid infrastructures that offer their users a dependableservice at an unprecedented scale. Depending on the flavor of middleware services these infrastructures deploy (for instance Condor,gLite, Globus, UNICORE, to name only a few) different interfaces to program the Grid infrastructures are provided. Despite ongoingefforts to standardize Grid service interfaces, there are still significant differences in how applications can interface to a Grid infrastructure.In this paper we describe the middleware (gLite) and services deployed on the EGEE Grid infrastructure and explain how applicationscan interface to them.
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| 27. |
- Laure, Erwin, et al.
(författare)
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Programming the grid with glite
- 2006
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Ingår i: Computational Methods in Science and Technology. - 1505-0602. ; 12:1, s. 33-45
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The past few years have seen the creation of the first production level Grid infrastructures that offer their users a dependable service at an unprecedented scale. Depending on the flavor of middleware services these infrastructures deploy (for instance Condor, gLite, Globus, UNICORE, to name only a few) different interfaces to program the Grid infrastructures are provided. Despite ongoing efforts to standardize Grid service interfaces, there are still significant differences in how applications can interface to a Grid infrastructure. In this paper we describe the middleware (gLite) and services deployed on the EGEE Grid infrastructure and explain how applications can interface to them.
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| 28. |
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| 29. |
- Palecek, David, et al.
(författare)
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Oscillatory Dynamics in Bacterial Reaction Centres Studied by Electronic 2D Spectroscopy
- 2013
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Ingår i: XVIIIth International Conference On Ultrafast Phenomena. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 41
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Konferensbidrag (refereegranskat)abstract
- Coherent dynamics in bacterial reaction centres were studied by electronic 2D spectroscopy at 80 K temperature. Polarization measurements together with Fourier analysis allowed assignment of observed population time beatings at different frequencies to the coherences of electronic and vibrational character.
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| 30. |
- Persson, P-A, et al.
(författare)
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Physical properties of pressure polymerized C60
- 1995
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Ingår i: High Pressure Science and Technology. - Singapore : World Scientific and Engineering Academy and Society. - 9810225474 ; , s. 716-718
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Konferensbidrag (refereegranskat)
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| 31. |
- Sharapov, S.E., et al.
(författare)
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Energetic particle instabilities in fusion plasmas
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104022-
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Tidskriftsartikel (refereegranskat)abstract
- Remarkable progress has been made in diagnosing energetic particle instabilities on present-day machines and in establishing a theoretical framework for describing them. This overview describes the much improved diagnostics of Alfvén instabilities and modelling tools developed world-wide, and discusses progress in interpreting the observed phenomena. A multi-machine comparison is presented giving information on the performance of both diagnostics and modelling tools for different plasma conditions outlining expectations for ITER based on our present knowledge.
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| 32. |
- Soldatov, Alexander, et al.
(författare)
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Fullerenes and fullerene nanostructures
- 1996
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Ingår i: Fullerenes and fullerene nanostructures. - Singapore : World Scientific and Engineering Academy and Society. - 9810228538 ; , s. 344-348
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Konferensbidrag (refereegranskat)
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| 33. |
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| 34. |
- Abdelhamid, Hani Nasser, et al.
(författare)
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CelloZIFPaper : Cellulose-ZIF hybrid paper for heavy metal removal and electrochemical sensing
- 2022
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Ingår i: Chemical Engineering Journal. - : Elsevier BV. - 1385-8947 .- 1873-3212. ; 446
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Tidskriftsartikel (refereegranskat)abstract
- The processing of hierarchical porous zeolitic imidazolate frameworks (ZIF-8) into a cellulose paper using sheet former Rapid-Kothen (R.K.) is reported. The procedure is a promising route to overcome a significant bottleneck towards applying metal-organic frameworks (MOFs) in commercial products. ZIF-8 crystals were integrated into cellulose pulp (CP) or TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical)-oxidized cellulose nanofibrils (TOCNF) following an in-situ or ex-situ process; the materials were denoted as CelloZIFPaper_In Situ and CelloZIFPaper_Ex Situ, respectively. The materials were applied as adsorbents to remove heavy metals from water, with adsorption capacities of 66.2-354.0 mg/g. CelloZIFPaper can also be used as a stand-alone working electrode for the selective sensing of toxic heavy metals, for instance, lead ions (Pb2+), using electrochemical-based methods with a limit of detection (LOD) of 8 mu M. The electrochemical measurements may advance 'Lab-onCelloZIFPaper' technologies for label-free detection of heavy metal ions.
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| 35. |
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| 36. |
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| 37. |
- Archambault, Alexi N., et al.
(författare)
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Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer
- 2020
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 158:5, s. 1274-1286.e12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC.METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants.RESULTS: Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 x 10(-5)). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings.CONCLUSIONS: In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures.
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| 38. |
- Berndt, Sonja, I, et al.
(författare)
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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
- 2022
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Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 36:12, s. 2835-2844
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Tidskriftsartikel (refereegranskat)abstract
- Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
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| 39. |
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| 40. |
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| 41. |
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| 42. |
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| 43. |
- Bydén, M., et al.
(författare)
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Phase equilibria in two aqueous chiral surfactant systems
- 1997
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Ingår i: Progress in Colloid and Polymer Science. - 0340-255X .- 1437-8027. ; 105, s. 360-364
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we present the binary phase diagrams of the pure (R)- and the racemic aqueous sodium-2-methyldecanoate surfactant systems. The latter is a 1:1 mixture of the pure (S)- and pure (R)-form. The systems were investigated using crossed polaroids, polarizing optical microscope and 2HNMR splittings. Both systems form a micellar phase, followed by a hexagonal, some intermediate phase and a large cubic phase. At even higher concentrations, the 2HNMR studies showed larger quadrupolar splittings up to 1200 Hz, due to a lamellar phase. The intermediate phase was in both cases very narrow, and extended up to > 23°C in the racemic system and up to 30°C in the pure (R)-system. The similarity between these two binary phase diagrams indicates that the change in molecular packing is so small that it does not drastically affect the phase behavior. The Krafft temperature in the micellar phase in both systems is 1°C, which is very low compared to that of unsubstituted alkanoates with the same chain length.
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| 44. |
- Båth, Petra, 1988, et al.
(författare)
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Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction centre
- 2022
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Ingår i: Acta Crystallographica Section D-Structural Biology. - : International Union of Crystallography (IUCr). - 2059-7983. ; 78, s. 698-708
-
Tidskriftsartikel (refereegranskat)abstract
- Serial crystallography is a rapidly growing method that can yield structural insights from microcrystals that were previously considered to be too small to be useful in conventional X-ray crystallography. Here, conditions for growing microcrystals of the photosynthetic reaction centre of Blastochloris viridis within a lipidic cubic phase (LCP) crystallization matrix that employ a seeding protocol utilizing detergent-grown crystals with a different crystal packing are described. LCP microcrystals diffracted to 2.25 angstrom resolution when exposed to XFEL radiation, which is an improvement of 0.15 angstrom over previous microcrystal forms. Ubiquinone was incorporated into the LCP crystallization media and the resulting electron density within the mobile Q(B) pocket is comparable to that of other cofactors within the structure. As such, LCP microcrystallization conditions will facilitate time-resolved diffraction studies of electron-transfer reactions to the mobile quinone, potentially allowing the observation of structural changes associated with the two electron-transfer reactions leading to complete reduction of the ubiquinone ligand.
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| 45. |
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| 46. |
- Crabtree, Judy S, et al.
(författare)
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Of mice and MEN1 : Insulinomas in a conditional mouse knockout.
- 2003
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Ingår i: Molecular and Cellular Biology. - 0270-7306 .- 1098-5549. ; 23:17, s. 6075-6085
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Tidskriftsartikel (refereegranskat)abstract
- Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1 gene. A conditional mouse model was developed to evaluate the loss of the mouse homolog, Men1, in the pancreatic beta cell. Men1 in these mice contains exons 3 to 8 flanked by loxP sites, such that, when the mice are crossed to transgenic mice expressing cre from the rat insulin promoter (RIP-cre), exons 3 to 8 are deleted in beta cells. By 60 weeks of age, >80% of mice homozygous for the floxed Men1 gene and expressing RIP-cre develop multiple pancreatic islet adenomas. The formation of adenomas results in elevated serum insulin levels and decreased blood glucose levels. The delay in tumor appearance, even with early loss of both copies of Men1, implies that additional somatic events are required for adenoma formation in beta cells. Comparative genomic hybridization of beta cell tumor DNA from these mice reveals duplication of chromosome 11, potentially revealing regions of interest with respect to tumorigenesis.
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| 47. |
- Dalmas, T., et al.
(författare)
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Introduction
- 2014
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Ingår i: Proceedings 2014 Workshop on Dialogue in Motion, DM 2014. - : Association for Computational Linguistics (ACL).
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Konferensbidrag (refereegranskat)
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| 48. |
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| 49. |
- Edlund, B, et al.
(författare)
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Anthropometry, body composition and body image in dieting and non-dieting 8-16-year-old Swedish girls.
- 1999
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Ingår i: Acta Paediatrica. - 0803-5253 .- 1651-2227. ; 88:5, s. 537-44
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Tidskriftsartikel (refereegranskat)abstract
- Anthropometry, body composition and body image were studied in 122 Swedish 8-16-y-old girls and their parents. The subjects participated in a 3-y prospective longitudinal study and were selected randomly after stratification for grades from those scoring in the upper vs. the lower thirds of the Children's Eating Attitudes Test (ChEAT) score distribution. The ChEAT was completed 6 mo before the present study together with a demographic and dieting questionnaire and a questionnaire for the estimation of body size. In total 43% (n = 52) admitted ever dieting ("Dieters") and 25% (n = 30) admitted that they were currently trying to lose weight. The anthropometric and body composition data indicated that ChEAT High-scorers and Dieters were somewhat fatter than Low-scorers and Non-dieters, although this pattern was not shown among the 8-y-olds or the 14-y-olds (High-scorers). The mothers of the ChEAT High-scorers were found to be somewhat fatter than the other mothers. A current vs. ideal body shape discrepancy was shown for both High-scorers and Dieters, with a larger discrepancy for the Dieters. All groups believed that their parents were aspiring for a leaner body.
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| 50. |
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