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1.	Edlund, Ann-Catrine, 1959-, et al. (författare) Basttulijani och Janosa Eva. Personnamn och identifikation i Kågeträskdagboken 1891–1901 2020 Ingår i: Namn i skrift. Names in Writing. - Göteborg : Meijerbergs institut för etymologisk forskning. - 9789172760981 - 9789187850035 ; , s. 37-59 Konferensbidrag (refereegranskat)abstract In this paper we explore the relationship between unofficial personal names and socialidentification in a peasant diary from Kågeträsk in the county of Västerbotten, datingfrom 1891–1901. From a total of 208 unique personal names we have extracted 169 unofficial personal names. Three categories of unofficial names have thereby been identified and closely analysed. The social aspects that are highlighted in the name formation are gender, place and kinship. The most extensive category consists of names where the kinship relation to the father is indicated: Adams Oskar and Nickes Tilda (60 names). The second category consists of unofficial names formed in relation to place-names: Bastulid-Johan and Strand-Alma (44 names). The third category consistsof personal names for married women given in relation to the name of her husband:Roberts Greta (17 names). The analysis shows that gender is a particularly salient social aspect in all three categories. The most part of the unofficial names used in the diary are men’s names, either their own unofficial name or the name of theirson, daughter or wife. The kinship relations that are indicated by the unofficial names hereby departs from the man in the household, whereas the kinship relations to the woman in the household are unmarked and therefore invisible in the personal naming. The social identification that is indicated by the personal names may also position women and men in different social domains. Both men and women may be identified by their kinship relation to their father and their belonging to a certain place. But while men tend to be identified as sons belonging to the village, women tend to be identified both as servants, daughters, wives or daughters-in-law belonging to the particular farm.
2.	Edlund, Ann-Catrine, 1959-, et al. (författare) Kågeträskdagboken : En västerbottnisk dagbok 1891–1901 med kommentarer. Volym 2. 2022 Bok (övrigt vetenskapligt/konstnärligt)abstract Kågeträskdagboken är tillkommen mellan 1891 och 1901. Den är skriven av systrarna Greta Dahlqvist (1859–1947) och Lovisa Dahlqvist (1862–1938), som bodde på Anten-Ors gård i Kågeträsk i norra Västerbotten. I dagboken får vi en inblick i det dagliga livet på gården: här redovisas i detaljer husfolkets utomhusarbete under vår, sommar och höst samt kvinnornas inomhusarbete under vinterhalvåret med vävning, stickning och andra aktiviteter. Det sociala livet i byn har en framträdande plats i dagboken, och uppgifter om nattfrierier, giftermål, födslar och död finns noggrant dokumenterade. Själva dagboksutgåvan består av två volymer. I den första får man en omfattande presentation av dagbokens historiska och sociala sammanhang, och där finns också person-, ortnamns- och ordregister samt en käll- och litteraturförteckning. I denna andra volym återfinns hela dagboken med tolkning och omfattande språkliga och innehållsliga kommentarer. En tredje volym behandlar de vis- och gåtböcker som sammanställdes på Anten-Ors gård under samma tid.I den tryckta boken presenteras en dagbokssida på varje uppslag. På den högra sidan återfinns renskriften, på den vänstra sidan översättningen/tolkningen. I pdf:en presenteras dagboken istället sida för sida, vilket innebär att det inte är möjligt att läsa renskrift och översättning intill varandra.
3.	Kågeträskdagboken, volym 2 : En västerbottnisk dagbok 1891–1901 med kommentarer 2022. - 1 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract Kågeträskdagboken är tillkommen mellan 1891 och 1901 på Anten-Ors gård i norra Västerbotten och är skriven av de två systrarna Greta Dahlqvist (1859– 1947) och Lovisa Dahlqvist (1862–1938). I föreliggande volym återger vi hela dagboken med tolkning och kommentarer. I Kågeträskdagbokens volym I ges en fördjupad presentation av det historiska och sociala sammanhang där Kågeträskdagboken tillkom. Där finns också tre register: Personregister, Ort- namnsregister och Ordregister. Käll- och litteraturförteckning för källor och litteratur som åberopas i fotnoterna i volym II återfinns också i volym I. Gretas och Lovisas förstaspråk var Skelleftemålet. Talad rikssvenska hade de mött som uppläsningsspråk i mer officiella sammanhang, och i skolan lärde de sig skriva svenska. Dagbokstexten utmärker sig av starka dialektala inslag samtidigt som det är uppenbart att de båda skribenterna haft starka ambitio- ner att följa normen för det svenska riksspråket. Detta gör dagboken till ett intressant forskningsobjekt inom skriftbruksforskning som är ett tvärveten- skapligt område. För att det ska vara möjligt för nutida läsare att ta del av såväl originaltex- ten som dagbokens innehåll har vi valt att återge en noggrann transkription av dagboksanteckningarna tillsammans med en tolkning. Varje enskild dagboks- sida presenteras på ett uppslag där den radrätt återgivna transkriptionen åter- finns på den högra sidan och tolkningen på den vänstra. I volym I beskriver vi hur vi gått till väga vid redigering av transkriptionen och vilka överväganden som gjorts vid tolkningen I dagboksutgåvan återfinns två typer av numrering, dels en löpande num- rering, dels en särskild numrering av dagbokssidorna; se även innehållsförteck- ningen. Dagbokshandskriften består av tre anteckningsböcker och en stor mängd lösa blad. Numreringen av dagbokssidorna utgår från de fem sviter av anteckningar som vi upprättat: i exempelvis numreringen 4:2 anger siffran 4 dagbokssvitens nummer, medan siffran 2 säger att det är sidan 2 i denna svit. Vart och ett av dagboksåren inleds med en vinjett som kort sammanfattar några av de händelser som redovisas i anteckningarna. Intill vinjetten finns en konstbild framställd av bildkonstnär Maria Sundström som gestaltar ett dagboksutdrag. För att kunna förstå dagbokstexten krävs kunskap om dialekten, men även god kunskap om den lokala geografin och om den jordbruks- och hantverkster- minologi som används. Därför har vi utarbetat en omfattande notapparat med ingående kommentarer. Vissa ord och sakförhållanden återkommer naturligt- vis, men för att göra det möjligt för läsaren att direkt hitta en förklaring av textstället upprepas samma kommentar, en del gånger i något förkortat skick. Mängder av dialektala ord förklaras, såsom ”Med slåttanna (slåtanna) avses ’tiden för slåtter av hö’”, där dagbokens återgivning av det aktuella ordet (i detta fall slåtanna) återgivits inom parentes. I noterna kommenteras ock- så ett stort antal kulturhistoriska fenomen, såsom t.ex. njutsminne: ”När man avslutat ett hästköp kunde det beseglas med att man drack njutsminne, dvs. man drack en köpskål.” De människor som omtalas i dagboken presenteras med officiellt namn och födelseår, såsom ”Rånings-Nisch, dvs. Nils Johansson Holmqvist (1845–1907)”. I personregistret i volym I återfinner man utförliga informationer om de aktuella personerna.I fotnoterna finns dessutom hänvisningar till de tre kartor och 13 stamtavlor som inleder volym II. Kartorna är följande: Karta 1. Gårdar i Kågeträsk under sent 1800-tal; Karta 2. Platser i närmiljön; Karta 3. Byar i närmiljön. Många av de människor som omnämns i dagboken är släktingar till husfolket på Anten-Ors gård. För att det ska vara möjligt att se släktskapsrelationerna mellan de olika personerna har vi upprättat stamtavlor för Anten-Ors och de- ras släktingar. De totalt tretton stamtavlorna nämner drygt 300 personer.
4.	Steneberg, Pär, et al. (författare) PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients 2018 Ingår i: JCI INSIGHT. - : American Society for Clinical Investigation. - 2379-3708. ; 3:12 Tidskriftsartikel (refereegranskat)abstract AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage imposed by physical activity and caloric restriction. We here report on the identification of PAN-AMPK activator O304, which - in diet-induced obese mice - increased glucose uptake in skeletal muscle, reduced beta cell stress, and promoted beta cell rest. Accordingly, O304 reduced fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin. T2D is associated with devastating micro-and macrovascular complications, and O304 improved peripheral microvascular perfusion and reduced blood pressure both in animals and T2D patients. Moreover, like exercise, O304 activated AMPK in the heart, increased cardiac glucose uptake, reduced cardiac glycogen levels, and improved left ventricular stroke volume in mice, but it did not increase heart weight in mice or rats. Thus, O304 exhibits a great potential as a novel drug to treat T2D and associated cardiovascular complications.
5.	Batch process strategy for analysing metabolic variation controlling the growth process of hybrid aspen 2005 Proceedings (redaktörskap) (populärvet., debatt m.m.)abstract High resolution magic angle spinning proton nuclear magnetic resonance spectroscopy, {1}H HR/MAS NMR, and multivariate data analysis using batch processing, BP, was applied for the analysis of two different genotypes of poplar tree (Populus tremula L. x tremuloides Michx.), containing an antisense construct of PttMYB76 and control (wild type). A gene encoding a MYB transcription factor, with unknown function, PttMYB76, was selected from a cambial EST library of poplar tree (Populus tremula L. x remuloides Michx.) for metabonomic characterisation. The PttMYB76 gene is believed to affect different paths of the phenyl propanoid synthetic pathway. This pathway leads to the formation of S- and G-lignin, flavonoids and sinapate esters. Milled poplar samples collected at the internodes of the tree were analysed using {1}H high resolution magic angle spinning NMR spectroscopy. The application of multivariate batch processing of the NMR results revealed a growth-related gradient in the plant internode direction as well as the discrimination between the trees with down regulated PttMYB76 expression and wild type populations. This paper is focused on the potential of a new analytical multivariate approach for analysing time-related plant metabonomic data. The techniques used could, with the aid of suitable model compounds, be of high relevance to the detection and understanding of the different lignification processes within the two types of poplar tree. Additionally, the findings are highlighting the importance of applying robust and organised multivariate data analysis approaches to facilitate modelling and interpretation of complex biological data sets.
6.	Buevich, Alexei V, et al. (författare) NMR studies of calcium-binding to mutant alpha-spectrin EF-hands 2004 Ingår i: CELLULAR & MOLECULAR BIOLOGY LETTERS. - 1425-8153. ; 9:1, s. 167-86 Tidskriftsartikel (refereegranskat)abstract The co-operative calcium binding mechanism of the two C-terminal EF-hands of human all-spectrin has been investigated by site-specific mutagenesis and multi-dimensional NMR spectroscopy. To analyse the calcium binding of each EF-hand independently, two mutant structures (E33A and D69S) of wild type alpha-spectrin were prepared. According to NMR analysis both E33A and D69S were properly folded. The unmutated EF-hand in these mutants remained nearly intact and active in calcium binding, whereas the mutated EF-hand lost its affinity for calcium completely. The apparent calcium binding affinity of the E33A mutant was much lower compared to the D39S mutant (similar to2470 muM and similar to240 muM, respectively). When the chemical shift perturbations were followed upon calcium titration, a positive correlation between the D69S mutant and the binding of the first calcium ion to the wild type was revealed. These observations showed that the first EF-hand in spectrin binds the first calcium ion and thereby triggers a conformational change that allows the second calcium ion to bind to the other EF-hand.
7.	Edlund, Ann-Catrine, 1959-, et al. (författare) Språk och kön 2007 Bok (populärvet., debatt m.m.)
8.	Edlund, Karolina, et al. (författare) Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors 2012 Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:24, s. 9551-9556 Tidskriftsartikel (refereegranskat)abstract Cancer mutation databases are expected to play central roles in personalized medicine by providing targets for drug development and biomarkers to tailor treatments to each patient. The accuracy of reported mutations is a critical issue that is commonly overlooked, which leads to mutation databases that include a sizable number of spurious mutations, either sequencing errors or passenger mutations. Here we report an analysis of the latest version of the TP53 mutation database, including 34,453 mutations. By using several data-driven methods on multiple independent quality criteria, we obtained a quality score for each report contributing to the database. This score can now be used to filter for high-confidence mutations and reports within the database. Sequencing the entire TP53 gene from various types of cancer using next-generation sequencing with ultradeep coverage validated our approach for curation. In summary, 9.7% of all collected studies, mostly comprising numerous tumors with multiple infrequent TP53 mutations, should be excluded when analyzing TP53 mutations. Thus, by combining statistical and experimental analyses, we provide a curated mutation database for TP53 mutations and a framework for mutation database analysis.
9.	Edlund, Ulf, 1957-, et al. (författare) A composite ply failure model based on continuum damage mechanics 2004 Ingår i: Composite structures. - : Elsevier BV. - 0263-8223 .- 1879-1085. ; 65:3-4, s. 347-355 Tidskriftsartikel (refereegranskat)abstract A material model including the failure behaviour is derived for a thin unidirectional (UD) composite ply. The model is derived within a thermodynamic framework and the failure behaviour is modelled using continuum damage mechanics. The following features describe the model: (i) The ply is assumed to be in a plane state of stress. (ii) Three damage variables associated with the stress in the fibre-, transverse and shear directions, respectively, are used. (iii) The plastic behaviour of the matrix material is modelled. (iv) The difference in the material response in tensile and compressive loading is modelled. (v) Rate dependent behavior of plasticity and damage (i.e. strength) is modelled.
10.	Edlund, Ulf, et al. (författare) A model of an adhesively bonded joint with elastic-plastic adherends and a softening adhesive 2009 Ingår i: Computer Methods in Applied Mechanics and Engineering. - : Elsevier BV. - 0045-7825 .- 1879-2138. ; 198:5-8, s. 740-752 Tidskriftsartikel (refereegranskat)abstract This paper deals with the generalization of a model of an adhesively bonded joint with the aim to allow elastic-plastic adherends. In the model of the joint that we extend, the thinness of the bodies and the low Youngs modulus of the adhesive were used to obtain a simplified model where the parts are described as material surfaces. We formulate an elastic-plastic material model with isotropic hardening expressed in the generalized stress and strain measures used for the surface description of the joint. The finite element formulation and the numerical treatment of the constitutive law are discussed. Numerical results showing the accuracy of the proposed treatment of the adherends are presented. Two failure load computations, using a softening material model for the adhesive, are presented and compared with experiments. The results show the importance of taking into account potential plastic deformations in the adherends in failure load computations.
11.	Edlund, Ulf, 1945- (författare) Studier av 2-cykloaminoindener speciellt med hänsyn till prototropa omlagringar 1974 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis is a short review of six papers (Papers 1-6,page 5) concerning studies of enamines from 2-indanones. The unusually stable 2-(N-pyrrolidyl)indene has been studied (Paper 2 ). As a base catalyst this enamine rearranges 1-methylindene to 3-methylindene with a lower rate constant compared with triethylamine. During this 1, 3-prototropic rearrangement no hydrogen exchange was observed (Paper 1).Special attention has been drawn to 1,3-rearrangements ofalkyl-substituted enamines of 2-indanone. From 1-methyl-2-indanone, which was most conveniently prepared by oxidation of the corresponding indene, a series of enamines has been prepared with varying amine components. A study of the kinetic control of the formation of these enamines showed that the less substituted double-bond isomer was formed more rapidly than the other form. Furthermore, the nature of the amine group has a significant influence on the composition of the equilibrium mixture observed, but the isomeric ratios obtained were unexpected in the light of earlier investigations of enamines from 2-methylcyclohexanone (Paper l).A 13C NMR study of these 2-cycloaminoindenes showed that introduction of a 1-methyl substituent caused a decrease in overlap but the magnitude of this perturbation was almost independent of the variation of the amine component. Furthermore, when using pyrrolidineor hexamethyleneimine as amine parts this decrease in overlap was of a comparable magnitude with the diminished conjugation noted in the 3-methyl isomers. However, when piperidine or morpholine was used the decreased delocalization was more pronounced in the 3-methyl tautomers compared with the 1-methyl analogues (Paper6).One isomer, 1-methyl-2-(N-piperidyl)indene, has been shown to undergo base- as well as acid-catalyzed 1,3-tautomerizations in pyridine solvent. The isomerization rates using 1,4-diazabicyclo-(2.2.2.)octane or quinuclidine as base catalysts were considerably slower than the rate of the acid-catalyzed reaction or the base-catalyzed rearrangement rates involving alkyl-substituted indenes as substrates. This retarding effect, caused by the amine group, is in agreement with differences in pKA values obtained via simple Hückel calculation (Paper 4).The reaction between pyrrolidine and 1-(2-indanylidene)indan--2-one has been investigated. Two possible mechanisms were suggested for the formation of products consisting of a linear dienamine and an indenyl-substituted enamine (9:1). In the main product, isolated by recrystallization, the indenyl substituent was shown to be twisted out of conjugation. This dienamine also underwent acid-catalyzed isomerization to form the enamine product (Paper 3).Convenient syntheses of the pharmacologically interesting N-substituted 2-aminoindanes have also been described. The perchlorate salts of the enamines were treated with sodium borohydride in methanol to afford the desired products (Paper 5).
12.	Ekbäck, Gustav, et al. (författare) The Effects of Platelet Rish Plasmapheresis in Total Hip Replacement Surgery on Platelet Activation Studied by Flow Cytometry Annan publikation (övrigt vetenskapligt/konstnärligt)abstract Background: Autologous platelet rich plasma (PRP) harvest with autotransfusion devices has been used for ten years in cardiac surgery and recently in orthopedics. Its influence on the outcome of surgery is still controversial, in part because of methodological difficulties in studying platelet function during surgery.Methods: Twenty patients undergoing primary total hip replacement (THR) were studied. Ten patients underwent an immediately preoperative platelet apheresis forming concentrated platelet rich plasma (c-PRP). Ten patients not undergoing apheresis were allocated to a control group. Platelet activation was evaluated as the population expressing P-Selektin on the surface of platelets in the c-PRP and in blood samples collected pre-, per- and postoperatively. The method used was flow cytometry.Results and Conclusions: There is a minor population of activated platelets circulating in the patient's blood with a highly significant difference between patients (p=0.005) with a range of 1-23 % in peroperative activation. PRP harvest did not significantly alter platelet activity. The platelet apheresis procedure did not inhibit platelet function in the c-PRP as judged by a high proportion of platelets that could be activated in ADP stimulation experiments (mean value±SD 86%±7.5%).The total number of platelets that could be activated in the c-PRP estimated as % ADP activated platelets x % sampled platelets in the c-PRP (total platelet yield), was non significantly correlated (r=-0.59, p<0.l) with postoperative bleeding, indicating a possible hemostatic effect of these platelets.
13.	Ekbäck, Gustav, et al. (författare) Tranexamic Acid Reduces Blood Loss in Total Hip Replacement Surgery 2000 Ingår i: Anesthesia and Analgesia. - 0003-2999 .- 1526-7598. ; 91:5, s. 1124-1130 Tidskriftsartikel (refereegranskat)abstract Intraoperatively administered, tranexamic acid (TA) does not reduce bleeding in total hip replacement (THR). Therefore, its prophylactic use was attempted in the present study because this has been shown to be more effective in cardiac surgery. We investigated 40 patients undergoing THR in a prospective, randomized, double-blinded study. Twenty patients received TA given in two bolus doses of 10 mg/kg each, the first just before surgical incision and the second 3 h later. In addition, a continuous infusion of TA, 1.0 mg · kg−1 · h−1 for 10 h, was given after the first bolus dose. The remaining 20 patients formed a control group. Both groups used preoperative autologous blood donation and intraoperative autotransfusion. Intraoperative bleeding was significantly less (P = 0.001) in the TA group compared with the control group (630 ± 220 mL vs 850 ± 260 mL). Postoperative drainage bleeding was correspondingly less (P = 0.001) (520 ± 280 vs 920 ± 410 mL). Up to 10 h postoperatively, plasma D-dimer concentration was halved in the TA group compared with the control group. One patient in each group had an ultrasound-verified late deep vein thrombosis. In conclusion, we found TA, administrated before surgical incision, to be efficient in reducing bleeding during THR.
14.	Ekman-Ordeberg, G, et al. (författare) Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro 2009 Ingår i: Acta Obstet Gynecol Scand. - : Wiley. ; 88:9, s. 984-989 Tidskriftsartikel (refereegranskat)abstract OBJECTIVES: The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical ripening and if the anticoagulative activity is necessary for its effect. DESIGN: Experimental in vitro study. SETTING: Lund University and Karolinska Institute, Sweden. METHODS: The effect of low molecular weight heparins with or without anticoagulative properties on myometrial contractility was measured in vitro on smooth muscle strips from biopsies obtained at elective cesarean sections. The effects on cervical ripening were assessed in cervical fibroblasts cultured from explants of cervical biopsies obtained at delivery. MAIN OUTCOME MEASURES: Mean force and number of contractions in uterine smooth muscle strips and interleukin-8 (IL-8) secretion in cervical fibroblasts. RESULTS: Myometrial smooth muscle strips pretreated with low molecular weight heparins showed increased contractile activity compared to untreated smooth muscle strips. Secretion of IL-8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin. Both these effects were independent of anticoagulative activity of the low molecular weight heparin. CONCLUSIONS: A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL-8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo. Our data support the notion that anticoagulant activity is not required to promote labor.
15.	Elg Christoffersson, Kristina, et al. (författare) Characterisation of dissolving pulp using designed process variables, NIR and NMR spec-troscopy, and multivariate analysis 1999 Ingår i: Cellulose. ; 6, s. 233-249 Tidskriftsartikel (refereegranskat)
16.	Elg Christoffersson, Kristina, et al. (författare) Chemical properties and cellulose su-permolecular structure of dissolving pulps with different reac-tivity revealed by solid state NMR, NIR spectra and multivari-ate data analysis Annan publikation (övrigt vetenskapligt/konstnärligt)
17.	Elg Christoffersson, Kristina, et al. (författare) Reactivity of dissolving pulp : characterisation using chemical properties, NMR spectros-copy and multivariate data analysis 2002 Ingår i: Cellulose. ; 9, s. 159-170 Tidskriftsartikel (refereegranskat)
18.	Elg Christoffersson, Kristina, et al. (författare) Reactivity of dissolving pulp: characterisation using chemical properties, NMR spectroscopy and multivariate data analysis 2002 Ingår i: Cellulose. ; 9:2, s. 159-70 Tidskriftsartikel (refereegranskat)abstract The reactivity of dissolving pulp was experimentally determined in termsof residual cellulose in viscose. The correlations between 11 chemicalproperties of pulp and filter values and residual cellulose contents of viscosewere then investigated by multivariate data analysis. Both the viscose filtervalue and the residual cellulose were well modelled from the 11 propertiesby partial least squares regression. The results show that pulps with highacetone extractable fractions, high magnesium contents, low alkali resistanceand low viscosity, gave low viscose filter values and low residual cellulosecontents. Pulps with low residual cellulose contents also had low carboxylgroupcontents and low polydispersity. The results are interpreted as that in pulpwith high reactivity, the hemicellulose content is low and that the cellulosechains are shorter and more soluble in alkali. An explanation of the positiveeffect from the high extractive content is that the extractives facilitate thediffusion of carbon disulfide. A principal component analysis of CP/MAS13C-NMR spectral data of six pulp samples showed that differences inreactivity between the pulps could be explained by variations in the hydrogenbonds in the cellulose and/or changes in the glucosidic bonds. In a separatestudy electron beam processing enhanced the reactivity, i.e. lowered theresidual cellulose content, of the investigated pulps. The magnitude of theelectron dose, within the tested range (5.4–23.7 kGy), didnotseem to be important, but the reactivity within pulp sheets tended to be ratherinhomogeneous.
19.	Engelheart, Stina, 1976-, et al. (författare) Matlådor till pensionärer i Örebro län : pilotstudie med kartläggning och provsmakning i tolv kommuner 2012 Rapport (övrigt vetenskapligt/konstnärligt)
20.	Fahlgren, Anna, et al. (författare) Direct ex vivo measurement of the fluid permeability of loose scar tissue 2012 Ingår i: Acta of Bioengineering and Biomechanics. - Wroclaw, Poland : Wroclaw University of Technology. - 1509-409X. ; 14:2, s. 47-51 Tidskriftsartikel (refereegranskat)abstract Fluid flow is important in many biomechanical models, but there is a lack of experimental data that quantifies soft tissue permeability. We measured the tissue permeability in fibrous soft tissue, using a novel technique to obtain specimens by allowing soft tissue to grow into coralline hydroxyapatite scaffoldings implanted between the abdominal muscle layers of rats.
21.	Fahlgren, Anna, et al. (författare) Fluid pressure and flow as a cause of bone resorption 2010 Ingår i: Acta Orthopaedica. - : Taylor & Francis. - 1745-3674 .- 1745-3682. ; 81:4, s. 508-516 Tidskriftsartikel (refereegranskat)abstract Background Unstable implants in bone become surrounded by an osteolytic zone. This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced by fluctuations in fluid pressure or flow, caused by implant instability. Method To understand the roles of pressure and flow, we describe the 3-dimensional distribution of osteolytic lesions in response to fluid pressure and flow in a previously reported rat model of aseptic loosening. 50 rats had a piston inserted in the proximal tibia, designed to produce 20 local spikes in fluid pressure of a clinically relevant magnitude (700 mmHg) twice a day. The spikes lasted for about 0.3 seconds. After 2 weeks, the pressure was measured in vivo, and the osteolytic lesions induced were studied using micro-CT scans. Results Most bone resorption occurred at pre-existing cavities within the bone in the periphery around the pressurized region, and not under the piston. This region is likely to have a higher fluid flow and less pressure than the area just beneath the piston. The velocity of fluid flow was estimated to be very high (roughly 20 mm/s). Interpretation The localization of the resorptive lesions suggests that high-velocity fluid flow is important for bone resorption induced by instability.
22.	Goulley, Joan, et al. (författare) BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. 2007 Ingår i: Cell Metabolism. - 1550-4131. ; 5:3, s. 207-219 Tidskriftsartikel (refereegranskat)
23.	Gromov, SP, et al. (författare) Novel supramolecular charge-transfer systems based on bis(18-crown-6)stilbene and viologen analogues bearing two ammonioalkyl groups 2005 Ingår i: NEW JOURNAL OF CHEMISTRY. - : Royal Society of Chemistry (RSC). - 1144-0546 .- 1369-9261. ; 29:7, s. 881-94 Tidskriftsartikel (refereegranskat)abstract A series of new viologen analogues bearing two ammonioalkyl groups (2-4) were synthesized in order to study their complexation with bis(18-crown-6)stilbene (1b). Electronic spectroscopy and H-1 NMR measurements show that in acetonitrile, bis( crown) stilbene 1b forms highly stable 1 : 1 and 2 : 1 charge-transfer (CT) complexes with pi-acceptors 2-4 owing to host-guest bonding. The influence of geometric and electronic factors on the complex formation constants are discussed. The structures of the supramolecular CT complexes are analyzed on the basis of H-1 and C-13 NMR data obtained in solution and in the solid state. X-Ray diffraction data for 1b and for model tetramethoxystilbene are also reported.
24.	Gromov, Sergey P, et al. (författare) Novel Photoswitchable Receptors: Synthesis and Cation-Induced Self-Assembly into Dimeric Complexes Leading to Stereospecific [2+2]-Photocycloaddition of Styryl Dyes Containing a 15-Crown-5 Ether Unit 2003 Ingår i: The Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 68:16, s. 6115-25 Tidskriftsartikel (refereegranskat)abstract Styryl dyes 4a-e containing a 15-crown-5 ether unit and a quinoline residue with a sulfonatoalkyl or sulfonatobenzyl N-substituent were synthesized. The relationship between the photochemical behavior of these dyes and their aggregates derived from complexation with Mg2+ in MeCN was studied using 1H NMR and absorption spectroscopy. The E-isomers of 4a-e were shown to form highly stable dimeric (2:2) complexes with Mg2+. Upon irradiation with visible light, the dimeric complexes undergo two competing photoreactions, viz., geometric E Z isomerization, resulting in an anion-capped 1:1 complex of the Z-isomer with Mg2+ and stereospecific syn-head-to-tail [2+2]-cycloaddition, affording a single isomer of bis-crown-containing cyclobutane. The N-substituent in the dye has a dramatic effect on the photochemical behavior of the dimeric complex. Molecular dynamics and semiempirical quantum-chemical calculations were carried out to interpret the observed photocycloaddition in the dimer. Conformational equilibria for the dimer of (E)-4b were analyzed using 1H NMR spectroscopy.
25.	Gromov, S P, et al. (författare) Self-assembly of a (benzothiazolyl)ethenylbenzocrown ether into a sandwich complex and stereoselective [2+2] photocycloaddition 2005 Ingår i: RUSSIAN CHEMICAL BULLETIN. - : Springer Science and Business Media LLC. - 1066-5285 .- 1573-9171. ; 54:7, s. 1569-79 Tidskriftsartikel (refereegranskat)abstract In the presence of Ba2+ ions, (benzothiazolyl)ethenylbenzocrown ether forms the stable sandwich complex 2L center dot Ba2+ with an unusual structure, in which the benzothiazole fragments are arranged one above the other. Irradiation of the sandwich complex with visible light induces stereoselective [2+2] cycloaddition giving rise to two "head-to-head" isomers of biscrown-cyclobutane. The addition of dibasic dicarboxylic acids that additionally stabilize the sandwich complex in a favorable conformation affects the isomer ratio of the cyclobutanes formed. The conformational equilibria for the sandwich complex and cyclobutanes were studied by H-1 N MR spectroscopy.
26.	Gromov, Sergey P, et al. (författare) Synthesis, Structure, Spectroscopic Studies, and Complexation of Novel Crown Ether Butadienyl Dyes 2002 Ingår i: Helvetica Chimica Acta. ; 85:1, s. 60-81 Tidskriftsartikel (refereegranskat)abstract Butadienyl dyes of the benzothiazole series with various fragments of benzocrown ethers 1a-c were synthesized for the first time. The structures and spectral properties of crown-containing butadienyl dyes and their complexes with alkali and alkaline-earth metal cations were studied by X-ray diffraction analysis and 1H-NMR, UV/VIS, and resonance Raman spectroscopy. To interpret the experimental results, quantum-chemical calculations were performed. In the case of Sr2+ and Ba2+ ions, the formation of strong sandwich complexes [M(1b)2]2+ of an unusual structure involving stacking interactions was established; the dye molecules are arranged one above another in the complex according to the head-to-head' pattern.
27.	Hauksson, Jón B, et al. (författare) NMR processing techniques based on multivariate data analysis and orthogonal signal correction. 13C CP/MAS NMR spectroscopic characterization of softwood kraft pulp 2001 Ingår i: Magnetic Resonance in Chemistry. - : Wiley. - 0749-1581 .- 1097-458X. ; 39:5, s. 267-75 Tidskriftsartikel (refereegranskat)abstract This paper presents a novel way of extracting information from a series of severely overlapped NMR spectra using multivariate data analysis techniques. A number of softwood pulps were prepared from wood chips that were subjected to kraft cooking conditions in laboratory digesters. In addition to measurements of traditional physical parameters, the pulps were characterized using standard 13C CP/MAS NMR spectroscopy. The relationship between the kappa number and both the NMR time domain and frequency domain data was modeled using multivariate data analysis techniques. The variation in the NMR spectra that was not correlated with the kappa number was removed using a new preprocessing tool, orthogonal signal correction (OSC). The resulting OSC-treated NMR spectra were used as descriptors to generate partial least-squares projections to latent structures (PLS) models for the variation of the kappa number. PLS weights were used to generate NMR sub-spectra which correspond to changes in the pulps that occur as the pulping process proceeds from high to low values of the kappa number. The sub-spectra were used to gain insight into the changes in the pulps occurring at the molecular level. Concomitant changes in cellulose crystallinity and the amounts of hemicellulose and lignin were observed in these sub-spectra. Copyright © 2001 John Wiley & Sons, Ltd.
28.	Hauksson, Jón B, et al. (författare) Prediction of basic wood properties for Norway spruce. Interpretation of Near Infrared Spectroscopy data using partial least squares regression 2001 Ingår i: Wood Science and Technology. - : Springer Science and Business Media LLC. - 0043-7719 .- 1432-5225. ; 35:6, s. 475-85 Tidskriftsartikel (refereegranskat)abstract This work was undertaken to investigate the feasibility of using near infrared spectroscopy (NIR) and partial least squares regression (PLS) as a tool to characterize the basic wood properties of Norway Spruce (Picea abies (L.) Karst.). The wood samples originated from a trial located in the province of Västerbotten in Sweden. In this trial, the effects of birch shelterwoods (Betula pendula Roth) of different densities on growth and yield in Norway spruce understorey were examined. All Norway spruce trees in each shelterwood treatment were divided into three growth rate classes based on diameter at breast height (1.3 m) over bark. Five discs were cut from each tree (i.e. from the root stem, and at 20%, 40%, 60%, and 80% of the total height). The discs from 40% tree height were used (i.e., where the largest variations in annual ring widths and wood density were found). A total of 27 discs were selected. The discs were used for measuring annual ring widths, wood density, average fiber length and the fiber length distributions. Milled wood samples prepared from the discs were used for recording NIR spectra. PLS regression was used to generate prediction models for the wood properties (Y-matrix) and NIR spectra (X-matrix) as well as between the wood properties (Y-matrix) and the fiber length distributions (X-matrix). One set of models was generated using untreated spectra and fiber length distributions. For a second set of models the structure in the X-matrix, which was orthogonal to the matrix described by the wood properties, was eliminated using a soft target rotation technique called orthogonal signal correction (OSC). The PLS model obtained using "raw" untreated NIR spectra and fiber length distributions had a poor modeling power as evidenced by the cumulative Q2 values. For the PLS models based on untreated NIR spectra the cumulative Q2 values ranged from a minimum of 16% (wood density) to a maximum of 46% (no. of annual rings). Orthogonal signal correction of the X-matrix (NIR spectra or fiber length distributions) gave PLS models with a modeling power corresponding to cumulative Q2 values well in excess of 70%. The improvement in predictive ability accomplished by the OSC procedure was verified by placing four of the 27 observations in an external test set and comparing RMSEP values for the test set observations without OSC and with OSC.
29.	Hedenström, Mattias, et al. (författare) Visualization and interpretation of OPLS models based on 2D NMR Data 2008 Ingår i: Chemometrics and Intelligent Laboratory Systems. - : Elsevier. - 0169-7439 .- 1873-3239. ; 92:2, s. 110-117 Tidskriftsartikel (refereegranskat)abstract Multivariate analysis on spectroscopic 1H NMR data is well established in metabolomics and other fields where the composition of complex samples is studied. However, biomarker identification can be hampered by overlapping resonances. 2D NMR data provides a more detailed “fingerprint” of the chemical structure and composition of the sample with greatly improved spectral resolution compared to 1H NMR data. In this report, we demonstrate a procedure for the construction of multivariate models based on frequency domain 2D NMR data where the loadings can be visualized as highly informative 2D loading spectra. This method is based on the analysis of raw spectral data without any need for peak picking or integration prior to analysis. Spectral features such as line widths and peak positions are thus retained. Hence, the loadings can be visualized and interpreted on a molecular level as pseudo 2D spectra in order to identify potential biomarkers. To demonstrate this strategy we have analyzed HSQC spectra acquired from populus phloem plant extracts originating from a set of designed experiments with OPLS regression.
30.	Ilegems, E., et al. (författare) Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion 2015 Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5 Tidskriftsartikel (refereegranskat)abstract The pancreatic islet of Langerhans is composed of endocrine cells producing and releasing hormones from secretory granules in response to various stimuli for maintenance of blood glucose homeostasis. In order to adapt to a variation in functional demands, these islets are capable of modulating their hormone secretion by increasing the number of endocrine cells as well as the functional response of individual cells. A failure in adaptive mechanisms will lead to inadequate blood glucose regulation and thereby to the development of diabetes. It is therefore necessary to develop tools for the assessment of both pancreatic islet mass and function, with the aim of understanding cellular regulatory mechanisms and factors guiding islet plasticity. Although most of the existing techniques rely on the use of artificial indicators, we present an imaging methodology based on intrinsic optical properties originating from mature insulin secretory granules within endocrine cells that reveals both pancreatic islet mass and function. We demonstrate the advantage of using this imaging strategy by monitoring in vivo scattering signal from pancreatic islets engrafted into the anterior chamber of the mouse eye, and how this versatile and noninvasive methodology permits the characterization of islet morphology and plasticity as well as hormone secretory status.
31.	Janson, Martin, et al. (författare) Analysis of patient selection and external validity in the Swedish contribution to the COLOR trial. 2009 Ingår i: Surgical endoscopy. - : Springer Science and Business Media LLC. - 1432-2218 .- 0930-2794. ; 23:8, s. 1764-9 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: The colon cancer laparoscopic or open resection (COLOR) trial is an international, randomised controlled trial comparing outcomes of open and laparoscopic surgery for colon cancer. The main purpose of this study was to determine representability by comparing included and nonincluded patients in the participating Swedish centres. DESIGN: At eight centres, which included 391 of the 422 Swedish patients, a local database search was performed to identify retrospectively all patients (n = 2,384) who underwent surgery for colon cancer during the inclusion period, and data was retrieved from medical records. RESULTS: Four hundred fifty-six patients were randomised, 65 of whom were excluded post randomisation (group 2), leaving 391 patients in the study (group 1). For 1,566 patients, valid exclusion criteria were found (group 3). Thus, 362 patients were eligible but not included (group 4). Relative to group 1, patients in group 4 had a significantly higher American Society of Anaesthesiologists (ASA) score, more advanced tumour stage and difference regarding the resections performed. Results showed that 1470 patients (62%) could be calculated as feasible for laparoscopic colon resection (LCR) in a clinical, nontrial situation. CONCLUSIONS: The study population in the Swedish part of the COLOR trial was representative of the eligible population with the exception of comorbidity, where those actually included had less severe comorbidity than the nonincluded but eligible patients. In Sweden, 50-60% of colon cancer patients can be operated on by laparoscopy.
32.	Johansson, Lars, 1963-, et al. (författare) A model for bone resorption 2006 Ingår i: ESDA 2006, 8th Biennial ASME Conference on Engineering Systems Design and Analysis,2006. - : ASME Press. - 0791837793 ; , s. 487-495 Konferensbidrag (refereegranskat)
33.	Johansson, Lars, 1963-, et al. (författare) Bone Resorption Induced by Fluid Flow 2009 Ingår i: Journal of Biomechanical Engineering. - : ASME. - 0148-0731 .- 1528-8951. ; 131:9, s. 094505-1-094505-5 Tidskriftsartikel (refereegranskat)abstract A model where bone resorption is driven by stimulus from fluid flow is developed and used as a basis for computer simulations, which are compared with experiments. Models for bone remodeling are usually based on the state of stress, strain, or energy density of the bone tissue as the stimulus for remodeling. We believe that there is experimental support for an additional pathway, where an increase in the amount of osteoclasts, and thus osteolysis, is caused by the time history of fluid flow velocity, fluid pressure, or other parameters related to fluid flow at the bone/soft tissue interface of the porosities in the bone.
34.	Johansson, Lars, et al. (författare) Fluid-induced osteolysis: modelling and experiments 2011 Ingår i: COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. - : Taylor and Francis. - 1025-5842 .- 1476-8259. ; 14:4, s. 305-318 Tidskriftsartikel (refereegranskat)abstract A model to calculate bone resorption driven by fluid flow at the bone-soft tissue interface is developed and used as a basis for computer calculations, which are compared to experiments where bone is subjected to fluid flow in a rat model. Previous models for bone remodelling calculations have been based on the state of stress, strain or energy density of the bone tissue as the stimulus for remodelling. We believe that there is experimental support for an additional pathway where an increase in the amount of the cells directly involved in bone removal, the osteoclasts, is caused by fluid pressure, flow velocity or other parameters related to fluid flow at the bone-soft tissue interface, resulting in bone resorption.
35.	Klarbring, Anders, et al. (författare) Minimizing crack energy release rate by topology optimization 2018 Ingår i: Structural and multidisciplinary optimization (Print). - : SPRINGER. - 1615-147X .- 1615-1488. ; 58:4, s. 1695-1703 Tidskriftsartikel (refereegranskat)abstract Fatigue cracked primary aircraft structural parts that cannot be replaced need to be repaired by other means. A structurally efficient repair method is to use adhesively bonded patches as reinforcements. This paper considers optimal design of such patches by minimizing the crack extension energy release rate. A new topology optimization method using this objective is developed as an extension of the standard SIMP compliance optimization method. The method is applied to a cracked test specimen that resembles what could be found in a real fuselage and the results show that an optimized adhesively bonded repair patch effectively reduces the crack energy release rate.
36.	Lewis, Jeffrey, et al. (författare) The effect of subsurface military detonations on vadose zone hydraulic conductivity, contaminant transport and aquifer recharge 2013 Ingår i: Journal of Contaminant Hydrology. - : Elsevier. - 0169-7722 .- 1873-6009. ; 146, s. 8-15 Tidskriftsartikel (refereegranskat)abstract Live fire military training involves the detonation of explosive warheads on training ranges. The purpose of this experiment is to evaluate the hydrogeological changes to the vadose zone caused by military training with high explosive ammunition. In particular, this study investigates artillery ammunition which penetrates underground prior to exploding, either by design or by defective fuze mechanisms. A 105 mm artillery round was detonated 2.6 m underground, and hydraulic conductivity measurements were taken before and after the explosion. A total of 114 hydraulic conductivity measurements were obtained within a radius of 3m from the detonation point, at four different depths and at three different time periods separated by 18months. This data was used to produce a three dimensional numerical model of the soil affected by the exploding artillery round. This model was then used to investigate potential changes to aquifer recharge and contaminant transport caused by the detonating round. The results indicate that an exploding artillery round can strongly affect the hydraulic conductivity in the vadose zone, increasing it locally by over an order of magnitude. These variations, however, appear to cause relatively small changes to both local groundwater recharge and contaminant transport.
37.	Lundström, Ulf, 1953- (författare) Bebyggelsenamnen i Bureå, Burträsks och Lövångers socknar i Skellefteå kommun jämte studier av huvudleder och nybyggesnamn 2015 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis deals with place-names in the southern part of the municipality of Skellefteå in the province of Västerbotten, more precisely the parishes of Bureå, Burträsk and Lövånger. It consists of three different sections, first a survey of the settlement names in each parish, then a section on the second elements in these place-names, and finally a study of names of more recent settlements.The earliest place-names here are names like Blacke, Bureå, Bäck, Kräkånger and Lövånger. The second elements in the names from the medieval expansion period are mark, böle, byn, träsk, sjön and vattnet. Placenames of Nordic, Sami and Finnish origin are found in Skellefteå. The name Lossmen has its origin in Ume Sami and was then borrowed into Finnish. Originally Sami names are Gorkuträsk, Jäppnästjärnliden, Lubboträsk, Sittuträsk and Tavträskliden.The thesis consists of interpretations of the names on parishes, villages, farms and summer pastures, and in Bureå and Lövånger also the names of seasonal fishing stations.The second major section deals with the second elements included in village names, alternative village names, names of parts of villages and farm names. Here the second elements in place-names in Bureå, Burträsk and Lövånger are accounted for, as are the names in the parishes of Byske, Jörn and Skellefteå. This is followed by a discussion of the second elements in Västerbotten and quite often in other parts of Norrland as well.The third major section consists of an analysis of the names of recent settlements in the area. These were established from the 1730s and up to 1870. Founding settlements was a way of providing livelihoods for a rapidly growing population. The study comprises 726 names, of which 269 are in the primary area of investigation, the parishes of Bureå, Burträsk and Lövånger. Extensive comparisons are made continually with conditions in the parishes of Byske, Jörn and Skellefteå in the northern area. The aim of the study is to determine in greater detail what characterises the names of more recent settlements in the municipality of Skellefteå in terms of categories of settlement names, their frequency and distribution within the area. A comparison is also made between Skellefteå and the municipality of Vännäs (Hagervall 1986). One of Hagervall’s findings is that many names are not based on existing features. This thesis shows, however, hardly any cases of stereotype naming in Västerbotten and that in nearly all cases the names refer to features.
38.	Mucibabic, Marija, et al. (författare) alpha-Synuclein promotes IAPP fibril formation in vitro and beta-cell amyloid formation in vivo in mice 2020 Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10:1 Tidskriftsartikel (refereegranskat)abstract Type 2 diabetes (T2D), alike Parkinson's disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark. Although the major aggregating peptide in beta -cells of T2D patients is Islet Amyloid Polypeptide (IAPP), alpha-synuclein (alpha Syn), the aggregating peptide in substantia nigra neurons of PD patients, is expressed also in beta -cells. Here we show that alpha Syn, encoded by Snca, is a component of amyloid extracted from pancreas of transgenic mice overexpressing human IAPP (denoted hIAPPtg mice) and from islets of T2D individuals. Notably, alpha Syn dose-dependently promoted IAPP fibril formation in vitro and tail-vein injection of alpha Syn in hIAPPtg mice enhanced beta -cell amyloid formation in vivo whereas beta -cell amyloid formation was reduced in hIAPPtg mice on a Snca (-/-) background. Taken together, our findings provide evidence that alpha Syn and IAPP co-aggregate both in vitro and in vivo, suggesting a role for alpha Syn in beta -cell amyloid formation.
39.	Nilsson, David, et al. (författare) Pine and spruce roundwood species classification using multivariate image analysis on bark 2005 Ingår i: Holzforschung. - Berlin : Walter de Gruyter. - 0018-3830 .- 1437-434X. ; 59:6, s. 689-695 Tidskriftsartikel (refereegranskat)abstract Wood discs from 67 pine and 79 spruce logs were collected from a forest clearing. Three different 24-bit red-green-blue (RGB) images were acquired from the radial surface of each disc. The first image contained bark, the second image was a mixture of bark and wood surface, and the third image consisted only of wood surface. The image texture was compressed into vectors of Fourier-transformed wavelet coefficients. These were assembled in matrices and analysed by principal component analysis (PCA) and partial least-squares projections to latent structures (PLS). Classification using Fourier-transformed wavelet scales showed that the wood species could be predicted with 90% accuracy. A thorough examination of this classification showed that the predicting power of these models was mostly due to wavelet scales that represented the mean value of each colour channel. The prediction accuracy that could be obtained from coefficients representing image texture was generally low. The use of grey-level co-occurrence matrices prior to the wavelet transformation showed, however, that it is possible to classify the wood species of pine and spruce with an accuracy approaching 100%.
40.	Nilsson, David, et al. (författare) Prediction of thermo mechanical pulp brightness using NIR spectroscopy on wood raw material 2005 Ingår i: Paperi ja puu. - Helsinki : Suomen Paperi- ja Puutavaralehti Oy. - 0031-1243. ; 87:2, s. 102-109 Tidskriftsartikel (refereegranskat)abstract Partial Least Squares regression to latent structures was used to find a correlation between near-infrared reflectance spectra of samples of milled Norway Spruce (Picea abies) and ISO brightness of bleached thermo mechanical pulp. Logs of spruce were stored in climate chambers with different conditions for 14 weeks. A factorial design based on five variables was constructed to control the storage and to provide different brightness properties of the stored spruce logs. Wood samples were collected during the storage and they were analysed with near-infrared reflectance spectroscopy and later refined to thermo mechanical pulp. The pulp was bleached with both hydrogen peroxide and sodium dithionite. The ISO brightness of the bleached pulp was correlated to the near-infrared spectra of the untreated samples using Partial Least Squares regression to latent structures. The modelling showed that it is possible to predict the ISO brightness of bleached thermo mechanical pulp from near-infrared spectra of original wood raw material.
41.	Nilsson, David, 1972- (författare) Prediction of wood species and pulp brightness from roundwood measurements 2005 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis presents a number of studies, where a multivariate approach was taken to construct models that predict wood species and thermo mechanical pulp brightness from roundwood of Norway spruce and Scots pine. The first and second studies produced multivariate prediction models for wood species from the bark of spruce and pine. These models can be used for wood species classification and would replace the manual log assessment that takes place today. Principal Component Analysis, PCA, and Partial least squares projections to Latent Structures, PLS, were used to predict the wood species from multivariate measurements recorded from the bark of spruce and pine. Two different kinds of measurements were employed, near-infrared spectroscopy and digital imaging. Both methods showed that it was possible to predict the wood species with a high accuracy. The third and fourth studies of the thesis are related to the wood storage of roundwood and the deterioration of wood that occurs during the storage. The third study used an experimental design with five storage factors that provided different conditions for the analysed wood. The experimental design made it possible to identify the factors and the interaction between factors, which were important for the ISO brightness of peroxide and dithionite bleached thermo mechanical pulp, TMP. The final study of the thesis used NIR spectroscopy for predicting the ISO brightness of bleached TMP. Spectra recorded from stored wood were used to construct PLS prediction models.
42.	Nilsson, David, et al. (författare) The effect of designed wood storage on the brightness of bleached and unbleached thermo mechanical pulp 2003 Ingår i: Nordic Pulp & Paper Research Journal. ; 18:4, s. 369-76 Tidskriftsartikel (refereegranskat)abstract 60 Norway Spruce (Picea abies) logs were stored in climate chambers for 14 weeks in order to investigate the effect of wood storage on the brightness of thermo mechanical pulp. The storage conditions were altered according to an experimental design comprised of five factors; light, watering, temperature, tree growth and debarking. Wood samples were collected during the storage period and refined into thermo mechanical pulp. ISO brightness values were measured for the unbleached, the dithionite bleached and the hydrogen peroxide bleached thermo mechanical pulp samples that were refined from the stored wood. The decrease in ISO brightness after 14 weeks of wood storage was significant for some of the samples bleached with dithionite. It was found that the interaction between watering and light had a significant negative effect on the brightness of the unbleached and dithionite bleached samples. The samples bleached with hydrogen peroxide generally showed a more consistent ISO brightness. Only watering and temperature had a significant effect on the brightness of peroxide bleached thermo, mechanical pulp.
43.	Norlin, Stefan, et al. (författare) Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion. 2005 Ingår i: Diabetes. - 0012-1797. ; 54:1, s. 125-32 Tidskriftsartikel (refereegranskat)
44.	Oström, Maria, et al. (författare) Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells 2008 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 3:7, s. e2841- Tidskriftsartikel (refereegranskat)abstract The identification of secreted factors that can selectively stimulate the generation of insulin producing beta-cells from stem and/or progenitor cells represent a significant step in the development of stem cell-based beta-cell replacement therapy. By elucidating the molecular mechanisms that regulate the generation of beta-cells during normal pancreatic development such putative factors may be identified. In the mouse, beta-cells increase markedly in numbers from embryonic day (e) 14.5 and onwards, but the extra-cellular signal(s) that promotes the selective generation of beta-cells at these stages remains to be identified. Here we show that the retinoic acid (RA) synthesizing enzyme Raldh1 is expressed in developing mouse and human pancreas at stages when beta-cells are generated. We also provide evidence that RA induces the generation of Ngn3(+) endocrine progenitor cells and stimulates their further differentiation into beta-cells by activating a program of cell differentiation that recapitulates the normal temporal program of beta-cell differentiation.
45.	Parween, Saba, 1988- (författare) Diabetes in 3D : β-cell mass assessments in disease models & evaluation of SPECT based imaging 2016 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Diabetes is a rapidly growing disease with 415 million affected adults worldwide. The pancreatic endocrine cells, most importantly the insulin producing β-cells, play an important role in regulating blood glucose homeostasis. Type 1 diabetes (T1D) is characterized by the inability of the pancreas to secrete sufficient amounts of insulin due to autoimmune destruction of insulin producing β-cells. Type 2 diabetes (T2D) on the other hand is characterized by defects in insulin secretion and insulin sensitivity. Alterations in the β-cell mass (BCM) and/or function play a major role in the development and progression of the disease. Understanding BCM dynamics in disease models is therefore a key aspect for better interpretation of research results. In this thesis, we have used optical projection tomography (OPT) as a tool to evaluate a non-invasive imaging modality for β-cell scoring and to study disease dynamics in frequently used animal models for T1D and T2D.The possibility to monitor BCM in vivo would radically improve our competence in studying the pathogenesis of diabetes and in therapeutic interventions. Single photon emission computed tomography (SPECT) is a widely used technique that has become a promising approach to monitor changes in BCM in vivo. A key issue for using this approach is to evaluate the β-cell specificity and read out of the utilized radiotracers. This is most commonly performed by conventional stereological approaches, which rely on the extrapolation of 2D data. We developed a protocol for SPECT-OPT multimodal imaging that enables rapid and accurate cross evaluation of SPECT based assessments of BCM. While histological determination of islet spatial distribution was challenging, SPECT and OPT revealed similar distribution patterns of the radiotracer 111In-exendin-3 and insulin positive β-cell volumes respectively between different pancreatic lobes, both visually and quantitatively. We propose SPECT-OPT multimodal imaging as an accurate and better approach for validating the performance of β-cell radiotracers.The leptin deficient ob/ob mouse is a widely used model for studies of metabolic disturbances leading to T2D, including obesity and insulin resistance. By OPT imaging we created the first 3D-spatial and quantitative account of BCM distribution in this model. We observed a previously unreported degree of cystic lesions in hypertrophic islets, that were occupied by red blood cells (RBCs) and/or fibrin mesh. We propose that these lesions are formed by a mechanism involving the extravasation of RBCs/plasma due to increased blood flow and islet vessel instability. Further, our data indicate that the primary lobular compartments of the ob/ob pancreas have different potentials for expanding their β-cell population. Unawareness of these characteristics of β-cell expansion in ob/ob mice presented in this study may significantly influence ex vivo and in vivo assessments of this model in studies of β-cell adaptation and function. The tomographic data, on which this study was based, will be made publically available as a resource to the research community for the planning and interpretation of research involving this model.There are limited studies on early metabolic and functional changes of BCM in the settings of T1D. In order to assess initial metabolic alterations in BCM before the onset of diabetes, we characterized congenic diabetes prone Bio-breeding (BB) DR.lyp/lyp rats, a widely used model for T1D diabetes. We observed lower acute insulin response, reduced islet blood flow and a significant reduction in the BCM of small and medium sized islets at a very early stage (40 days), i.e. before insulitis and development of diabetes. Underlying changes in islet function may be a previously unrecognized factor of importance in the development of T1D.
46.	Persson, Per-Axel, et al. (författare) High-pressure polymerized C60 1996 Ingår i: Extended Abstracts of Carbon´96, European Carbon Conference, Newcastle-upon-Tyne 1996, volume 2. - : The British Carbon Group. ; , s. 746-747, s. 746-747 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
47.	Persson, Per-Axel, et al. (författare) NMR and Raman characterization of pressure polymerized C-60 1996 Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 258:5-6, s. 540-546 Tidskriftsartikel (refereegranskat)abstract Bulk C60 has been treated at 1.1 GPa and 550–585 K, producing a dense insoluble material which on heating to above 600 K reverts to normal C60. Raman and IR studies on modified material show a large number of new lines, and the Raman pentagon pinch mode shifts from 1469 to 1458 cm−1 as on photopolymerization. MAS NMR shows one broadened line at the original C60 shift 144 ppm and a small peak at about 77 ppm due to the bridging carbons. None of the new resonances observed for C60 polymerized by other methods were observed. The results verify previously suggested polymeric structures where the fullerence cages are connected by four-membered rings.
48.	Persson, Per-Axel, et al. (författare) Physical properties of pressure polymerized C60 1996 Ingår i: High Pressure Science and Technology. - Singapore : World Scientific. - 9810225474 ; , s. 716-718 Konferensbidrag (refereegranskat)abstract The properties of C60 have been studied after treatment at high temperature and high pressure (1.1 GPa and 565 K for 2 h). The treated material is insoluble in organic solvents. We present results obtained in NMR and Raman studies and measured data for the specific heat and the thermal expansion. Our results show clearly that there are no covalent bonds and no molecular rotation, but suggest that the molecules are slightly deformed and held together by weak pi-type bonds.
49.	Rolandsson, Olov, et al. (författare) Acute hyperglycemia induced by hyperglycemic clamp affects plasma Amyloid-β in type 2 diabetes 2024 Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 99:3, s. 1033-1046 Tidskriftsartikel (refereegranskat)abstract Background: Individuals with type 2 diabetes (T2D) have an increased risk of cognitive symptoms and Alzheimer's disease (AD). Mis-metabolism with aggregation of amyloid-β peptides (Aβ) play a key role in AD pathophysiology. Therefore, human studies on Aβ metabolism and T2D are warranted.Objective: The objective of this study was to examine whether acute hyperglycemia affects plasma Aβ1-40 and Aβ1-42 concentrations in individuals with T2D and matched controls.Methods: Ten participants with T2D and 11 controls (median age, 69 years; range, 66-72 years) underwent hyperglycemic clamp and placebo clamp (saline infusion) in a randomized order, each lasting 4 hours. Aβ1-40, Aβ1-42, and insulin-degrading enzyme (IDE) plasma concentrations were measured in blood samples taken at 0 and 4 hours of each clamp. Linear mixed-effect regression models were used to evaluate the 4-hour changes in Aβ1-40 and Aβ1-42 concentrations, adjusting for body mass index, estimated glomerular filtration rate, and 4-hour change in insulin concentration.Results: At baseline, Aβ1-40 and Aβ1-42 concentrations did not differ between the two groups. During the hyperglycemic clamp, Aβ decreased in the control group, compared to the placebo clamp (Aβ1-40: p = 0.034, Aβ1-42: p = 0.020), IDE increased (p = 0.016) during the hyperglycemic clamp, whereas no significant changes in either Aβ or IDE was noted in the T2D group.Conclusions: Clamp-induced hyperglycemia was associated with increased IDE levels and enhanced Aβ40 and Aβ42 clearance in controls, but not in individuals with T2D. We hypothesize that insulin-degrading enzyme was inhibited during hyperglycemic conditions in people with T2D.
50.	Sanandaji, Nima, 1981- (författare) Innate Confinement Effects in PCL Oligomers as a Route to Confined Space Crystallisation 2009 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract In this work, an in-depth analysis of crystalline characteristics has been performed for a unique set of strictly monodisperse poly-ε-caprolactone (PCL) oligomers. The molecules have different sets of end groups with various degrees of bulkiness and hydrogen bonding potential, affecting their aptitude to pack in ordered crystal structures. The oligomers also have different numbers of repeating units (n = 2-64), affecting the degree to which end groups influence overall molecular characteristics. The presence of bulky end groups leads to an innate confinement effect on crystallisation which in turn makes it possible to utilize the set of PCL oligomers to study confined space crystallisation. Confined space crystallisation is explored as a route to gain further understanding about the early metastable phases in crystal formation. The monodisperse nature of the samples made it possible to collect very precise small-angle and wide-angle X-ray scattering data (SAXS and WAXS) as well as calorimetric data. Computer modeling studies were performed to support experimental findings. It was shown that end groups strongly affected crystallisation features for the shorter oligomers (n ≤ 8) but to a lesser extend for the longer oligomers (n ≥ 16). The presence of a bulky end group at one end of an oligomer could inhibit the formation of hydrogen bonds on the other end. Short oligomers (n = 8) with OH-end groups exhibited novel packing characteristics. At one isothermal crystallisation temperature the molecules exhibited not only lamellar ordering but also an additional, likely rectangular or slanted, ordering. The sample was packed in a unique structure with molecular chains lying parallel but not aligned head to head with each other. At a higher crystallisation temperature the molecules packed in a double layered structure and at an even higher temperature in a typical non-folded but tilted single-molecular layer pattern. Unit cell determination was performed for a short oligomer with two bulky end groups, showing the existence of a tetragonal unit cell with different dimensions than the orthorhombic unit cells previously reported for linear PCL without end groups. To gain greater insight into the earliest stages of molecular packing, in situ WAXS measurements were performed using a synchrotron radiation beam and measuring data each 12 s whilst very slowly going from melt to isothermal crystallisation. It was shown that the crystal unit cell was distorted during the first minutes of slow crystallisation, which might either represent a metastable phase or else a highly distorted orthorhombic phase.

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