| 1. |
- Springett, Jane, 1952-, et al.
(författare)
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Annual report 2004
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Ek, Lena, 1961-, et al.
(författare)
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Analysis of Cognitive Dysfunction in Patients with Low-Grade Glioma
- 2005
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Ingår i: Journal of clinical psychology in medical settings. - : Springer. - 1068-9583 .- 1573-3572. ; 12:2, s. 165-173
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Tidskriftsartikel (refereegranskat)abstract
- All living adults with histopatologically proven diagnosis of low-grade glioma in a Swedish county were identified with help of the Regional Cancer Register, half of them (n = 24) participated in a neuropsychological evaluation. A considerable variation was found in cognitive function within this group of patients, ranging from good ability to severe disturbance. Different patterns of cognitive dysfunction emerged resulting in three subgroups; patients with severe, mild, and minimal selective dysfunction. The patients with severe disturbance had a global dysfunction covering most assessed cognitive domains. Slow information-processing speed was obvious in the subgroups with both severe and mild dysfunction. Cognitive problems present in the best performing group seemed related to tumor localization. Cognitive function in the whole sample was related to histopathological diagnosis of the tumor, as well as to educational level of the patients. The nonworking patients had significantly poorer performance than the working patients.
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| 3. |
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| 4. |
- Ek, Lena, 1961-
(författare)
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Cognitive Deficits Reflecting Diffuse and Focal Brain Lesions Caused by Slow Growing Brain Tumors - Low-grade Gliomas
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall purpose was to characterize the impact that low-grade glioma (LGG) – a type of slowly growing brain tumor – has on cognitive functions. Paper I was an in-depth analysis of cognitive dysfunction of patients with histological proven LGG. The pattern varied among patients, revealing three subgroups: 1) patients with severe cognitive dysfunction; 2) patients with mild cognitive dysfunction; 3) patients with selective dysfunction due to tumor localization. In the first two subgroups the patients had slowed information-processing speed. Patients with a favorable prognosis performed better than those with unfavorable prognosis. Nonworking patients showed more pronounced dysfunction than working patients. Paper II studied cognitive functions of patients who were in the early stage of the disease and had not yet received any major medical treatments. Patients’ performances ranked at the lower end of normal limits, which contrasted with those of the individually matched controls, whose performances ranked at the upper end. Patients had slower information-processing-speed and less effective executive functions. Patients with frontal tumors had various executive problems due to tumor localization. Paper III investigated cognitive impairment at the individual level in relation to neurological symptoms, radiological characteristics of the tumor, depression, and fatigue. Paper III included the same patients as Paper II. The results showed that the majority of the patients did not have more than selective impairment. One subgroup, consisting of younger patients with large left frontal tumors showed obvious cognitive impairment, including slowed information-processing speed. The thesis showed that diffuse brain injury was closely connected to LGG. A subgroup of patients in the early phase of the disease showed signs of mild diffuse brain injury. The majority of the patients who were in later stage of the disease displayed cognitive signs of diffuse brain injury.
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| 5. |
- Ek, Lena, 1961-, et al.
(författare)
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Early cognitive impairment in a subset of patients with presumed low-grade glioma
- 2010
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 16:6, s. 503-511
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the presence of cognitive impairment, in adults with presumed low-grade glioma at early stage of disease prior to major treatments, in relation to neurological symptoms and radiological characteristics of the tumour. Sixteen patients were evaluated. A subset of patients was identified with clearly impaired cognition. Patients with cognitive impairment often had large tumours in the left frontal lobe, were relatively young, and most of them were males. We conclude that cognitive dysfunction may be present already at early stage of disease, and that early identification of patients at risk is warranted.
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