| 1. |
- Krasilnikov, A., et al.
(författare)
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Evidence of 9 Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:2
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Tidskriftsartikel (refereegranskat)abstract
- The intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper.
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| 22. |
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Overview of the JET results
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
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Tidskriftsartikel (refereegranskat)
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| 23. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 24. |
- Romanelli, F, et al.
(författare)
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Overview of the JET results
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
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Tidskriftsartikel (refereegranskat)abstract
- Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
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| 25. |
- Bécoulet, A., et al.
(författare)
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Science and technology research and development in support to ITER and the Broader Approach at CEA
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10
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Tidskriftsartikel (refereegranskat)abstract
- In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented.
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| 26. |
- Noterdaeme, J. M., et al.
(författare)
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Heating, current drive and energetic particle studies on JET in preparation of ITER operation
- 2003
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 43:3, s. 202-209
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Tidskriftsartikel (refereegranskat)abstract
- This paper summarizes the recent work on JET in the three areas of heating, current drive and energetic particles. The achievements have extended the possibilities of JET, have a direct connection to ITER operation and provide new and interesting physics. Toroidal rotation profiles of plasmas heated far off axis with little or no refuelling or momentum input are hollow with only small differences on whether the power deposition is located on the low field side or on the high field side. With LH current drive the magnetic shear was varied from slightly positive to negative. The improved coupling (through the use of plasma shaping and CD4) allowed up to 3.4 MW of PLH in internal transport barrier (ITB) plasmas with more than 15 MW of combined NBI and ICRF heating. The q-profile with negative magnetic shear and the ITB could be maintained for the duration of the high heating pulse (8 s). Fast ions have been produced in JET with ICRF to simulate alpha particles: by using third harmonic He-4 heating, beam injected He-4 at 120 kV were accelerated to energies above 2 MeV taking advantage of the unique capability of JET to use NBI with 4 He and to confine MeV class ions. ICRF heating was used to replicate the dynamics of alpha heating and the control of an equivalent Q = 10 `burn' was simulated.
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| 27. |
- Pegourie, B., et al.
(författare)
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Deuterium inventory in Tore Supra : Coupled carbon-deuterium balance
- 2013
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 438:Suppl., s. S120-S125
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an analysis of the carbon-deuterium circulation and the resulting balance in Tore Supra over the period 2002-2007. Carbon balance combines the estimation of carbon gross erosion from spectroscopy, net erosion and deposition using confocal microscopy, lock-in thermography and SEM, and a measure of the amount of deposits collected in the vacuum chamber. Fuel retention is determined from post-mortem (PM) analyses and gas balance (GB) measurements. Special attention was paid to the deuterium outgassed during the nights and weekends of the experimental campaign (vessel under vacuum, Plasma Facing Components at 120 degrees C) and during vents (vessel at atmospheric pressure, PFCs at room temperature). It is shown that this outgassing is the main process reconciling the PM and GB estimations of fuel retention, closing the coupled carbon-deuterium balance. In particular, it explains why the deuterium concentration in deposits decreases with increasing depth.
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| 28. |
- Mayoral, M. -L, et al.
(författare)
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Overview of Recent Results on Heating and Current Drive in the JET tokamak
- 2009
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Ingår i: RADIO FREQUENCY POWER IN PLASMAS. - : AIP. - 9780735407534 ; , s. 39-46
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Konferensbidrag (refereegranskat)abstract
- In this paper, significant results in the heating and current drive domains obtained at JET in the past few years following systems upgrade and dedicated experimental time, will be reviewed. Firstly, an overview of the new Ion Cyclotron Resonance Frequency (ICRF) heating capabilities will be presented i.e. results from the ITER-Like ICRF antenna (ILA), the use of External Conjugate-T and 3dB hybrid couplers to increase the ICRF power during ELMy H-mode, Furthermore, experiments to study the influence of the phasing of the ICRF antenna on power absorption and coupling will be described. Looking at Low Hybrid (I-H) issues for ITER, the effect of the location of gas injection on the LH coupling improvement at large launcher-separatrix distances will be discussed as the possibility to operate at ITER-relevant power densities. Experiments to characterise the LH power losses in the Scrape-Off-Layer (SOL) and to determine the LH wave absorption and current drive using power modulation will be shown. Finally, plasma rotation studies in the presence of ICRF heating with standard and enhanced JET toroidal field ripple will be presented.
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| 29. |
- Ongena, J., et al.
(författare)
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Overview of recent results on Heating and Current Drive in JET
- 2007
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Ingår i: RADIO FREQUENCY POWER IN PLASMAS. - : AIP. ; , s. 249-256
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Konferensbidrag (refereegranskat)abstract
- Recent progress on heating and current drive on JET is reported. Topics discussed are: high power coupling of ICRF/LH at ITER relevant antenna/launcher-separatrix distances, succesfull demonstration of 3 dB couplers for ELM tolerance of the ICRF system, influence of ICRF on LH operation, rotation studies in plasma without external momentum with standard and enhanced JET toriodal field ripple, studies of different ICRF heating schemes and of NTM avoidance schemes using Ion Cyclotron Current Drive. A brief outlook on future plans for experiments at JET is given.
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| 30. |
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| 31. |
- Betancourt, Lazaro Hiram, et al.
(författare)
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Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data
- 2019
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Metastatic melanoma is one of the most common deadly cancers, and robust biomarkers are still needed, e.g. to predict survival and treatment efficiency. Here, protein expression analysis of one hundred eleven melanoma lymph node metastases using high resolution mass spectrometry is coupled with in-depth histopathology analysis, clinical data and genomics profiles. This broad view of protein expression allowed to identify novel candidate protein markers that improved prediction of survival in melanoma patients. Some of the prognostic proteins have not been reported in the context of melanoma before, and few of them exhibit unexpected relationship to survival, which likely reflects the limitations of current knowledge on melanoma and shows the potential of proteomics in clinical cancer research.
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| 32. |
- Betancourt, Lazaro Hiram, et al.
(författare)
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The human melanoma proteome atlas-Defining the molecular pathology
- 2021
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Ingår i: Clinical and Translational Medicine. - : Wiley. - 2001-1326. ; 11:7, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.
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| 33. |
- Carlsten, A, et al.
(författare)
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Antidepressant medication and suicide in Sweden
- 2001
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Ingår i: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 10:6, s. 525-530
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To explore a possible temporal association between changes in antidepressant sales and suicide rates in different age groups. METHODS: A time series analysis using a two-slope model to compare suicide rates in Sweden before and after introduction of the selective serotonin reuptake inhibitors, SSRIs. RESULTS: Antidepressant sales increased between 1977-1979 and 1995-1997 in men from 4.2 defined daily doses per 1000 inhabitants and day (DDD/t.i.d) to 21.8 and in women from 8.8 to 42.4. Antidepressant sales were twice as high in the elderly as in the 25-44-year-olds and eight times that in the 15-24-year-olds. During the same time period suicide rates decreased in men from 48.2 to 33.3 per 10(5) inhabitants/year and in women from 20.3 to 13.4. There was significant change in the slope in suicide rates after the introduction of the SSRI, for both men and women, which corresponds to approximately 348 fewer suicides during 1990-1997. Half of these 'saved lives' occurred among young adults. CONCLUSION: We demonstrate a statistically significant change in slope in suicide rates in men and women that coincided with the introduction of the SSRI antidepressants in Sweden. This change preceded the exponential increase in antidepressant sales.
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| 34. |
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| 35. |
- Decker, J., et al.
(författare)
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Modelling of LHCD at various densities in tore supra tokamak
- 2012
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Ingår i: 39th EPS Conference on Plasma Physics 2012, EPS 2012 and the 16th International Congress on Plasma Physics; Stockholm; Sweden; 2 July 2012 through 6 July 2012; Code 96757. - 9781622769810 ; 2, s. 934-937
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Konferensbidrag (refereegranskat)
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| 36. |
- Dumont, R.J., et al.
(författare)
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Advances in multi-megawatt, long pulse operation in Tore Supra
- 2012
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Ingår i: 39th EPS Conference on Plasma Physics 2012, EPS 2012 and the 16th International Congress on Plasma Physics; Stockholm; Sweden; 2 July 2012 through 6 July 2012; Code 96757. - 9781622769810 ; 2, s. 1118-1121
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Konferensbidrag (refereegranskat)
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| 37. |
- Ekedahl, A., et al.
(författare)
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Effect of gas injection during LH wave coupling at ITER-relevant plasma-wall distances in JET
- 2009
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 51:4
-
Tidskriftsartikel (refereegranskat)abstract
- Good coupling of lower hybrid (LH) waves has been demonstrated in different H-mode scenarios in JET, at high triangularity (delta similar to 0.4) and at large distance between the last closed flux surface and the LH launcher ( up to 15 cm). Local gas injection of D-2 in the region magnetically connected to the LH launcher is used for increasing the local density in the scrape-off layer ( SOL). Reciprocating Langmuir probe measurements magnetically connected to the LH launcher indicate that the electron density profile flattens in the far SOL during gas injection and LH power application. Some degradation in normalized H-mode confinement, as given by the H98(gamma,2)-factor, could be observed at high gas injection rates in these scenarios, but this was rather due to total gas injection and not specifically to the local gas puffing used for LH coupling. Furthermore, experiments carried out in L-mode plasmas in order to evaluate the effect on the LH current drive efficiency, when using local gas injection to improve the coupling, indicate only a small degradation (Delta I-LH/I-LH similar to 15%). This effect is largely compensated by the improvement in coupling and thus increase in coupled power when using gas puffing.
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| 38. |
- Ekedahl, A., et al.
(författare)
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Influence of gas puff location on the coupling of lower hybrid waves in JET ELMy H-mode plasmas
- 2012
-
Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 54:7, s. 074004-
-
Tidskriftsartikel (refereegranskat)abstract
- Reliable coupling of the lower hybrid current drive (LHCD) to H-mode plasmas in JET is made feasible through a dedicated gas injection system, located at the outer wall and magnetically connected to the antenna (Pericoli Ridolfini et al 2004 Plasma Phys. Control. Fusion 46 349, Ekedahl et al 2005 Nucl. Fusion 45 351, Ekedahl et al 2009 Plasma Phys. Control. Fusion 51 044001). An experiment was carried out in JET in order to investigate whether a gas injection from the top of the torus, as is foreseen for the main gas injection in ITER, could also provide good coupling of the LH waves if magnetically connected to the antenna. The results show that a top gas injection was not efficient for providing a reliable LHCD power injection, in spite of being magnetically connected and in spite of using almost twice the amount of gas flow compared with the dedicated outer mid-plane gas puffing system. A dedicated gas injection system, set in the outer wall and magnetically connected to the LHCD antenna, is therefore recommended in order to provide the reliable coupling conditions for an LHCD antenna in ITER.
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| 39. |
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| 40. |
- Hillairet, J., et al.
(författare)
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Recent progress on lower hybrid current drive and implications for ITER
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:7
-
Tidskriftsartikel (refereegranskat)abstract
- The sustainment of steady-state plasmas in tokamaks requires efficient current drive systems. Lower hybrid current drive is currently the most efficient method to generate a continuous additional off-axis toroidal plasma current and to reduce the poloidal flux consumption during the plasma current ramp-up phase. The operation of the Tore Supra ITER-like lower hybrid (LH) launcher has demonstrated the capability to couple LH power at ITER-like power densities with very low reflected power during long pulses. In addition, the installation of eight 700 kW/CW klystrons at the LH transmitter has allowed increasing the total LH power in long-pulse scenarios. However, in order to achieve pure stationary LH-sustained plasmas, some R&D is needed to increase the reliability of all the systems and codes, from radio-frequency (RF) sources to plasma scenario prediction. The CEA/IRFM is addressing some of these issues by leading a R&D programme towards an ITER LH system and by the validation of an integrated LH modelling suite of codes. In 2011, the RF design of a mode converter was validated at a low power. A 500 kW/5 s RF window is currently under manufacture and will be tested at a high power in 2012 in collaboration with the National Fusion Research Institute. All of this work aims to reduce the operational risks associated with the ITER steady-state operations.
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| 41. |
- Linnarsson, M K, et al.
(författare)
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Metal-contact enhanced incorporation of deuterium in 4H-and 6H-SiC
- 2000
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Ingår i: Materials Science Forum. - 0255-5476 .- 1662-9752. ; 338-3, s. 937-940, s. 937-940
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Tidskriftsartikel (refereegranskat)abstract
- Deuterium was introduced in p-type SiC from a gas ambient. The samples were partially coated with 200 Angstrom thick metal layer of titanium, nickel, platinum or gold. Heat treatments were performed in the temperature range 500-800 degreesC during 4 h. Secondary ion mass spectrometry (SIMS) was used to measure the deuterium content after deuterium exposure. The catalytic metal coating is shown to play an important role for introducing deuterium into SiC. Nickel and platinum facilitate hydrogen incorporation in p-type SiC, which may be due to an increased hydrogen concentration at the metal/SiC interface and/or an increase the H+ ions to H ratio. No in-diffusion of deuterium is observed using titanium although large quantities of deuterium are stored in the titanium film. Furthermore, gold reveals an inert character and does not promote in-diffusion of deuterium.
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| 42. |
- Lloyd-Spets, Anita, et al.
(författare)
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SiC based field effect gas sensors for industrial applications
- 2001
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Ingår i: Physica status solidi. A, Applied research. - 0031-8965 .- 1521-396X. ; 185:1, s. 15-25
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Tidskriftsartikel (refereegranskat)abstract
- The development and field-testing of high-temperature sensors based on silicon carbide devices have shown promising results in several application areas. Silicon carbide based field-effect sensors can be operated over a large temperature range, 100-600 degreesC, and since silicon carbide is a chemically very inert material these sensors can be used in environments like exhaust gases and flue gases from boilers. The sensors respond to reducing gases like hydrogen, hydrocarbons and carbon monoxide. The use of different temperatures, different catalytic metals and different structures of the gate metal gives selectivity to different gases and arrays of sensors can be used to identify and monitor several components in gas mixtures. MOSFET sensors based on SIC combine the advantage of simple circuitry with a thicker insulator, which increases the long term stability of the devices. In this paper we describe silicon carbide MOSFET sensors and their performance and give: examples of industrial applications such as monitoring of car exhausts and flue gases. Chemometric methods have been used for the evaluation of the data.
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| 43. |
- Malmstrom, M, et al.
(författare)
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Prescribing patterns for analgesics in relation to underprivileged area (UPA) score, mortality and suicide in 33 municipalities in the province of Skane, southern Sweden
- 1999
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Ingår i: Social Psychiatry and Psychiatric Epidemiology. - : Springer Science and Business Media LLC. - 0933-7954 .- 1433-9285. ; 34:5, s. 259-264
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Although it is well known that analgesics contribute to suicide, there is little knowledge about how much of the mortality and suicide can be explained by socioeconomic deprivation or by sales of analgesics. METHODS: This ecological study analyses the relationships between the sales (defined daily doses per 1000 inhabitants per day) of dextropropoxyphene, dextropropoxyphene combinations, paracetamol, codeine and paracetamol combinations, and other codeine combinations and the Swedish UPA (underprivileged area) score, mortality and suicide rates in 33 municipalities in Skane in 1987 and 1994 for people aged 20-64 years. The association of each of the subgroups of analgesics with all-cause mortality, and with standardised mortality rates for suicide, adjusted for UPA score, was investigated by using weighted (by population size) regression analysis. RESULTS: In 1994 there was a moderate to strong significant correlation between sales of analgesics and UPA scores, mortality and suicide (r = 0.49-0.78). Although UPA score explained 68.9% and 67.4% respectively of the variance between the analgesics and all-cause mortality and suicide, codeine and paracetamol combinations explained a further 10.1% of the variance in suicide. Dextropropoxyphene and codeine and paracetamol combinations explained an additional 3.8% and 2.9% respectively of the variance in mortality. CONCLUSIONS: Local prescription rates for analgesics were associated with mortality and suicide, when adjusted for socioeconomic deprivation defined as UPA score.
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| 44. |
- Nielsen, A.T., et al.
(författare)
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Hydrogen production from organic waste
- 2001
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Ingår i: International journal of hydrogen energy. - 0360-3199 .- 1879-3487. ; 26:6, s. 547-550
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Tidskriftsartikel (refereegranskat)abstract
- The extraction of pure hydrogen from the fermentation of household waste by a mixed anaerobic bacterial flora is demonstrated. Simulated household waste (600 g) was fermented in a bioreactor, which was continuously sparged with nitrogen (30 ml/min) fed in from the bottom. The gas stream from the biorector passes through a sulphide trap (ZnO) and then through a heated palladium-silver membrane reactor to separate hydrogen from the gas stream. In this way, waste remediation and biological hydrogen production is combined in a process where a large proportion of the hydrogen produced can be collected, free of other gaseous species from the fermentation. © 2001 International Association for Hydrogen Energy.
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| 45. |
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| 46. |
- Rantamäki, K., et al.
(författare)
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LH wave coupling over ITER-like distances at JET
- 2007
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Ingår i: Radio Frequency Power in Plasmas. - : American Institute of Physics (AIP). - 0735404445 - 9780735404441 ; , s. 261-264
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Konferensbidrag (refereegranskat)abstract
- Good coupling of LH power at plasma-launcher distance of 15 cm has been obtained at JET. Near-gas injection is used to increase the density in front of the grill. The role of LH power in the density increase at constant gas level is demonstrated. For the first time at JET the temperature of the hot spots caused by parasitic absorption of LH power has been measured.
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| 47. |
- Sanchez, Aniel, et al.
(författare)
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Novel functional proteins coded by the human genome discovered in metastases of melanoma patients
- 2020
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Ingår i: Cell Biology and Toxicology. - : Springer Science and Business Media LLC. - 0742-2091 .- 1573-6822. ; 36:3, s. 261-272
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Tidskriftsartikel (refereegranskat)abstract
- In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research over the last 10 years, and the introduction of novel therapies such as targeted therapies and immunomodulators, the rather dark horizon of the median survival has dramatically changed from under 1 year to several years. With the advent of proteomics, deep-mining studies can reach low-abundant expression levels. The complexity of the proteome, however, still surpasses the dynamic range capabilities of current analytical techniques. Consequently, many predicted protein products with potential biological functions have not yet been verified in experimental proteomic data. This category of ‘missing proteins’ (MP) is comprised of all proteins that have been predicted but are currently unverified. As part of the initiative launched in 2016 in the USA, the European Cancer Moonshot Center has performed numerous deep proteomics analyses on samples from MM patients. In this study, nine MPs were clearly identified by mass spectrometry in MM metastases. Some MPs significantly correlated with proteins that possess identical PFAM structural domains; and other MPs were significantly associated with cancer-related proteins. This is the first study to our knowledge, where unknown and novel proteins have been annotated in metastatic melanoma tumour tissue.
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| 48. |
- Savage, S, et al.
(författare)
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SiC based gas sensors and their applications
- 2000
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Ingår i: Materials Science Forum. - 0255-5476 .- 1662-9752. ; 353-3, s. 747-752
-
Tidskriftsartikel (refereegranskat)abstract
- The development and field-testing of hardy high-temperature sensors based on silicon carbide devices has to date shown promising results in several application areas. As the need to take care of the environment becomes more urgent, these small and relatively cheap sensors could be used to increase the monitoring of gases, or to replace or complement larger and more expensive sensor technologies used today. In this paper the development of Silicon Carbide MOSFET transistor sensors and Schottky diode sensors is described. The devices are tested in industrial applications such as monitoring of car exhausts and flue gases.
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| 49. |
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