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| 2. |
- Falhammar, Henrik, et al.
(författare)
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Fertility, Sexuality and Testicular Adrenal Rest Tumors in Adult Males with Congenital Adrenal Hyperplasia.
- 2012
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Ingår i: European journal of endocrinology. - 1479-683X. ; 166, s. 441-449
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Fertility in males with congenital adrenal hyperplasia (CAH) is reported from normal to severely impaired. We therefore investigated fertility/fecundity, social/sexual situation, and pituitary- gonadal function in CAH males.Subjects and methods: The patient cohort comprised 30 males with 21-hydroxylase deficiency, 19-67 yr. Their fertility was compared with age-matched national population data. For the evaluation of social/sexual factors and hormone status, age-matched controls were recruited (n=32). Subgroups of different ages (<30 years and older) and CYP21A2 genotypes: null (severe salt wasting), I2splice (milder salt wasting), and I172N (simple virilizing) were also studied. Patients underwent testicular ultrasound examination (n=21), and semen analysis (n=14).Results: Fertility was impaired in CAH males compared to national data (0.9±1.3 vs. 1.8±0.5 children/father, P<0.001). There were no major differences in social and sexual factors between patients and controls apart from more fecundity problems, particularly in the I172N group. The patients had lower testosterone/estradiol ratio and inhibin B, and higher FSH. The semen samples were pathological in 43% (6/14) of patients and sperm concentration correlated with inhibin B and FSH. Testicular adrenal rest tumours (TARTs) were found in 86% (18/21). Functional testicular volume correlated positively with the testosterone/estradiol ratio, sperm concentration and inhibin B. Patients with pathological semen had increased fat mass and indications of increased cardiometabolic risk.Conclusions: Fertility/fecundity was impaired in CAH males. The frequent occurrence of TARTs resulting in testicular insufficiency appears to be the major cause, but other factors such as elevated fat mass may contribute to a low semen quality.
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- Hofmann, Robin, et al.
(författare)
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Oxygen therapy in suspected acute myocardial infarction
- 2017
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Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 377:13, s. 1240-1249
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain. METHODS: In this registry-based randomized clinical trial, we used nationwide Swedish registries for patient enrollment and data collection. Patients with suspected myocardial infarction and an oxygen saturation of 90% or higher were randomly assigned to receive either supplemental oxygen (6 liters per minute for 6 to 12 hours, delivered through an open face mask) or ambient air. RESULTS: A total of 6629 patients were enrolled. The median duration of oxygen therapy was 11.6 hours, and the median oxygen saturation at the end of the treatment period was 99% among patients assigned to oxygen and 97% among patients assigned to ambient air. Hypoxemia developed in 62 patients (1.9%) in the oxygen group, as compared with 254 patients (7.7%) in the ambient-air group. The median of the highest troponin level during hospitalization was 946.5 ng per liter in the oxygen group and 983.0 ng per liter in the ambient-air group. The primary end point of death from any cause within 1 year after randomization occurred in 5.0% of patients (166 of 3311) assigned to oxygen and in 5.1% of patients (168 of 3318) assigned to ambient air (hazard ratio, 0.97; 95% confidence interval [CI], 0.79 to 1.21; P=0.80). Rehospitalization with myocardial infarction within 1 year occurred in 126 patients (3.8%) assigned to oxygen and in 111 patients (3.3%) assigned to ambient air (hazard ratio, 1.13; 95% CI, 0.88 to 1.46; P=0.33). The results were consistent across all predefined subgroups. CONCLUSIONS: Routine use of supplemental oxygen in patients with suspected myocardial infarction who did not have hypoxemia was not found to reduce 1-year all-cause mortality. (Funded by the Swedish Heart–Lung Foundation and others; DETO2X-AMI ClinicalTrials.gov number, NCT01787110.)
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- Seta, Takamasa, et al.
(författare)
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Pressure broadening coefficients of the water vapor lines at 556.936 and 752.033 GHz
- 2008
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier BV. - 0273-1177 .- 0022-4073. ; 109:1, s. 144-150
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Tidskriftsartikel (refereegranskat)abstract
- The air induced broadening coefficients of the pure rotational transitions of H2O at 556.936 GHz (110←101), and 752.033 GHz (211←202) were measured by terahertz time-domain spectroscopy. The air broadening coefficient was determined to be for the 556.936 GHz line and for the 752.033 GHz line, respectively. The present broadening coefficients for the 556.936 GHz water line are significantly smaller than those of Markov and Krupnov [Measurements of the pressure shift of the 1(10)–1(01) water line at 556.936 GHz produced by mixtures of gases. J Mol Spect 1995:172;211–4] but relatively close to the values of the HITRAN database. The measured data may improve the accuracy of the abundance of water vapor retrieved from spectra obtained by the Odin/SMR satellite instrument. The effect on the satellite retrieval processing is discussed.
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| 7. |
- Urban, Joachim, 1964, et al.
(författare)
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Odin/SMR Limb Observations of Stratospheric Trace Gases: Level 2 Processing of ClO, N2O, O3, and HNO3
- 2005
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 110:D14, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- The Sub-Millimetre Radiometer (SMR) on board the Odin satellite, launched on 20 February 2001, observes key species with respect to stratospheric chemistry and dynamics such as O-3, ClO, N2O, and HNO3 using two bands centered at 501.8 and 544.6 GHz. We present the adopted methodology for level 2 processing and the achieved in-orbit measurement capabilities of the SMR radiometer for these species in terms of altitude range, altitude resolution, and measurement precision. The characteristics of the relevant level 2 data versions, namely version 1.2 of the operational processor as well as versions 222 and 223 of the reference code, are discussed and differences are evaluated. An analysis of systematic retrieval errors, resulting from spectroscopic and instrumental uncertainties, is also presented.
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