| 1. |
- Bohlen, S, et al.
(författare)
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Physical therapy in Huntington's disease : towards objective assessments?
- 2013
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Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 20:2, s. 389-393
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Tidskriftsartikel (refereegranskat)abstract
- Background and purposePhysical therapy is recommended for the treatment of Huntington's disease, but reliable studies investigating its efficacy are almost non-existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy interventions aimed at improving gait and posture.MethodsTwelve patients with Huntington disease received a predefined twice-weekly intervention focusing on posture and gait over 6 weeks. The GAITRite mat and a force plate were used for objective and quantitative assessments. The Unified Huntingtons Disease Rating Scale Total Motor Score, the timed Up &Go test, and the Berg Balance Scale were used as clinical outcome measures.ResultsSignificant improvements were seen in GAITRite measures after therapy. Improvements were also seen in the Up & Go test and Berg Balance Scale, whereas force plate measures and Total Motor Scores did not change.ConclusionsThe results suggest that physical therapy has a positive effect on gait in Huntington's disease. The study shows that objective and quantitative measures of gait and posture may serve as endpoints in trials assessing the efficacy of physical therapy. They should be explored further in larger trials applying a randomized controlled setting.
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| 2. |
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| 3. |
- He, Yibo, et al.
(författare)
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A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
- 2023
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we have expressed monoclonal ACPAs derived from patients with RA, and analyzed their functions in mice, as well as their specificities. None of the ACPAs showed arthritogenicity nor induced pain-associated behavior in mice. However, one of the antibodies, clone E4, protected mice from antibody-induced arthritis. E4 showed a binding pattern restricted to skin, macrophages and dendritic cells in lymphoid tissue, and cartilage derived from mouse and human arthritic joints. Proteomic analysis confirmed that E4 strongly binds to macrophages and certainRA synovial fluid proteins such as α-enolase. The protective effect of E4 was epitope-specific and dependent on the interaction between E4-citrullinated α-enolase immune complexes with FCGR2B on macrophages, resulting in increased IL-10 secretion and reduced osteoclastogenesis. These findings suggest that a subset of ACPAs have therapeutic potential in RA.
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| 4. |
- Urciuoli, Luca, et al.
(författare)
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Exploring security effects on transport performance
- 2013
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Ingår i: International Journal of Shipping and Transport Logistics. - 1756-6517. ; 5:3, s. 303-321
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this investigation is to learn the effects of security on transport performance. The methodology is based on the analysis of multiple case studies, where data is collected by means of observations, focus groups, unstructured and semi-structured interviews. The findings from the empirical data seem to show that security measures may cause lower operational performance. Therefore, this paper discusses the importance of developing security capabilities to be integrated in existing logistics information systems. Only in this way will transport companies develop the capability to fully realise wins in terms of both security and efficiency.
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| 5. |
- Urciuoli, Luca, et al.
(författare)
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The effects of security on transport performance
- 2010
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Ingår i: Conference proceedings of World Conference on Transportation 2010. - : WCTR.
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Konferensbidrag (refereegranskat)abstract
- The purpose of this investigation is to emphasize the negative effects of security on transport performance. The methodology is based on the analysis of a large workshop with security experts and multiple case studies, where data is collected by means of observations, and unstructured and semi-structured interviews. The findings from the empirical data seem to demonstrate the initial hypothesis that security measures affect efficiency in terms of lower operational performance. Therefore, this paper discusses the importance of developing security capabilities to be integrated in existing logistics information systems. Only in this way will transport companies develop the capability to fully realize wins in terms of both security and efficiency.
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| 6. |
- Urciuoli, Luca, 1976, et al.
(författare)
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The effects of security on transport performance
- 2010
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Ingår i: Conference proceedings of World Conference on Transportation 2010.
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Konferensbidrag (refereegranskat)abstract
- The purpose of this investigation is to emphasize the effects of security on transport performance. The methodology is based on the analysis of a large workshop with security experts and multiple case studies, where data is collected by means of observations, and unstructured and semi-structured interviews. The findings from the empirical data seem to show that security measures may cause lower operational performance. Therefore, this paper discusses the importance of developing security capabilities to be integrated in existing logistics information systems. Only in this way will transport companies develop the capability to fully realize wins in terms of both security and efficiency.
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