| 1. |
|
|
| 2. |
- Semb, G, et al.
(författare)
-
Erratum
- 2017
-
Ingår i: Journal of plastic surgery and hand surgery. - 2000-6764. ; 51:2, s. 158-158
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Elander, N. O., et al.
(författare)
-
Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy
- 2018
-
Ingår i: British Journal of Cancer. - : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 118:8, s. 1084-1088
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Deoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma.METHODS: Immunohistochemical staining of DCTD and RRM1 was performed on tissue microarrays representing tumour samples from 303 patients in European Study Group for Pancreatic Cancer (ESPAC)-randomised adjuvant trials following pancreatic resection, 272 of whom had received gemcitabine or 5-fluorouracil with folinic acid in ESPAC-3(v2), and 31 patients from the combined ESPAC-3(v1) and ESPAC-1 post-operative pure observational groups.RESULTS: Neither log-rank testing on dichotomised strata or Cox proportional hazard regression showed any relationship of DCTD or RRM1 expression levels to survival overall or by treatment group.CONCLUSIONS: Expression of either DCTD or RRM1 was not prognostic or predictive in patients with pancreatic adenocarcinoma who had had post-operative chemotherapy with either gemcitabine or 5-fluorouracil with folinic acid.
|
|
| 4. |
|
|
| 5. |
- Elander, N. O., et al.
(författare)
-
Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer
- 2018
-
Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 118:7, s. 947-954
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Dihydropyrimidine dehydrogenase (DPD) tumour expression may provide added value to human equilibrative nucleoside transporter-1 (hENT1) tumour expression in predicting survival following pyrimidine-based adjuvant chemotherapy.Methods: DPD and hENT1 immunohistochemistry and scoring was completed on tumour cores from 238 patients with pancreatic cancer in the ESPAC-3(v2) trial, randomised to either postoperative gemcitabine or 5-fluorouracil/folinic acid (5FU/FA).Results: DPD tumour expression was associated with reduced overall survival (hazard ratio, HR = 1.73 [95% confidence interval, CI = 1.21-2.49], p = 0.003). This was significant in the 5FU/FA arm (HR = 2.07 [95% CI = 1.22-3.53], p = 0.007), but not in the gemcitabine arm (HR = 1.47 [0.91-3.37], p = 0.119). High hENT1 tumour expression was associated with increased survival in gemcitabine treated (HR = 0.56 [0.38-0.82], p = 0.003) but not in 5FU/FA treated patients (HR = 1.19 [0.80-1.78], p = 0.390). In patients with low hENT1 tumour expression, high DPD tumour expression was associated with a worse median [95% CI] survival in the 5FU/FA arm (9.7 [5.3-30.4] vs 29.2 [19.5-41.9] months, p = 0.002) but not in the gemcitabine arm (14.0 [9.1-15.7] vs. 18.0 [7.6-15.3] months, p = 1.000). The interaction of treatment arm and DPD expression was not significant (p = 0.303), but the interaction of treatment arm and hENT1 expression was (p = 0.009).Conclusion: DPD tumour expression was a negative prognostic biomarker. Together with tumour expression of hENT1, DPD tumour expression defined patient subgroups that might benefit from either postoperative 5FU/FA or gemcitabine.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Carlsund-Levin, Christina, et al.
(författare)
-
An exterior complex rotated coupled channel description of predissociation in diatomic molecules applied to a model of the four lowest (2)Sigma(+)-states in CaH
- 2002
-
Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; 65:4, s. 306-322
-
Tidskriftsartikel (refereegranskat)abstract
- The exterior complex rotated Coupled-Channel formulation of potential scattering makes it possible to calculate energies and widths for a non-adiabatic model of a diatomic molecule or quasimolecule, The structure and decay pattern of a diatomic system is in this way described in a non-perturbative way. In this contribution we use the non-adiabatic form of an empirically derived potential energy curve matrix, previously used by Martin, J. Chem. Phys. 88, 1997 (1988) [1], for the four lowest (2)Sigma(+)-states of the CaH radical to demonstrate how one can calculate term positions as well as non-radiative decay widths in a realistic case for a large range of rovibronic levels. The differences between the previously derived Born-Oppenheimer term values [1] and the present non-adiabatic results are discussed and compared with previous work.
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- Giunta, RE, et al.
(författare)
-
Correction: ESPRAS Survey: National and European Societies for Plastic Surgeons
- 2024
-
Ingår i: Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V.... - 1439-3980. ; 56:2, s. e2-
-
Tidskriftsartikel (refereegranskat)
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Olofsson Bagge, Roger, 1978, et al.
(författare)
-
Isolated Hepatic Perfusion With Melphalan for Patients With Isolated Uveal Melanoma Liver Metastases: A Multicenter, Randomized, Open-Label, Phase III Trial (the SCANDIUM Trial)
- 2023
-
Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 41:16, s. 3042-50
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSEAbout half of patients with metastatic uveal melanoma present with isolated liver metastasis, in whom the median survival is 6-12 months. The few systemic treatment options available only moderately prolong survival. Isolated hepatic perfusion (IHP) with melphalan is a regional treatment option, but prospective efficacy and safety data are lacking.METHODSIn this multicenter, randomized, open-label, phase III trial, patients with previously untreated isolated liver metastases from uveal melanoma were randomly assigned to receive a one-time treatment with IHP with melphalan or best alternative care (control group). The primary end point was overall survival at 24 months. Here, we report the secondary outcomes of response according to RECIST 1.1 criteria, progression-free survival (PFS), hepatic PFS (hPFS), and safety.RESULTSNinety-three patients were randomly assigned, and 87 patients were assigned to either IHP (n = 43) or a control group receiving the investigator's choice of treatment (n = 44). In the control group, 49% received chemotherapy, 39% immune checkpoint inhibitors, and 9% locoregional treatment other than IHP. In an intention-to-treat analysis, the overall response rates (ORRs) were 40% versus 4.5% in the IHP and control groups, respectively (P < .0001). The median PFS was 7.4 months versus 3.3 months (P < .0001), with a hazard ratio of 0.21 (95% CI, 0.12 to 0.36), and the median hPFS was 9.1 months versus 3.3 months (P < .0001), both favoring the IHP arm. There were 11 treatment-related serious adverse events in the IHP group compared with seven in the control group. There was one treatment-related death in the IHP group.CONCLUSIONIHP treatment resulted in superior ORR, hPFS, and PFS compared with best alternative care in previously untreated patients with isolated liver metastases from primary uveal melanoma.
|
|
| 17. |
- Rakityansky, S. A., et al.
(författare)
-
Pade approximation of the S-matrix as a way of locating quantum resonances and bound states
- 2007
-
Ingår i: J PHYS A-MATH THEOR. - : IOP Publishing. - 1751-8113. ; 40:49, s. 14857-14869
-
Tidskriftsartikel (refereegranskat)abstract
- It is shown that the spectral points (bound states and resonances) generated by a central potential of a single-channel problem, can be found using rational parametrization of the S-matrix. To achieve this, one only needs values of the S-matrix along the real positive energy axis. No calculations of the S-matrix at complex energies or a complex rotation are necessary. The proposed method is therefore universal in that it is applicable to any potential (local, non-local, discontinuous, etc) provided that there is a way of obtaining the S-matrix (or scattering phase shifts) at real collision energies. Besides this, combined with any method that extracts the phase shifts from the scattering data, the proposed rational parametrization technique would be able to do the spectral analysis using the experimental data.
|
|
| 18. |
|
|
| 19. |
- Stone-Elander, S, et al.
(författare)
-
Microwaving in F-18 chemistry: quirks and tweaks
- 2007
-
Ingår i: Ernst Schering Research Foundation workshop. - : Springer Berlin Heidelberg. - 0947-6075. ; :62, s. 243-69
-
Tidskriftsartikel (refereegranskat)
|
|
| 20. |
- Sunesson, Sune, et al.
(författare)
-
Introduction
- 1995
-
Ingår i: Remaking the welfare state. - 1 85972 051 X ; , s. 1-13
-
Bokkapitel (refereegranskat)
|
|
| 21. |
- Yakovlev, S. L., et al.
(författare)
-
Asymptotic Solution of A Multichannel Scattering Problem with A Nonadiabatic Coupling
- 2018
-
Ingår i: Theoretical and mathematical physics. - 0040-5779 .- 1573-9333. ; 195:3, s. 874-885
-
Tidskriftsartikel (refereegranskat)abstract
- We consider a multichannel scattering problem in an adiabatic representation. We assume that the nonadiabatic coupling matrix has a nontrivial value at large internuclear separations, and we construct asymptotic solutions at large internuclear distances. We show that these solutions up to the first order of the perturbation theory are identical to the asymptotic solutions of the reprojection approach, which was previously proposed as a means for solving the electron translation problem in the context of the Born-Oppenheimer method.
|
|
| 22. |
|
|
| 23. |
- Buentke, E, et al.
(författare)
-
Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells
- 2011
-
Ingår i: Blood Cancer Journal. - : Macmillan Publishers Limited. - 2044-5385. ; 1:e31, s. 9-
-
Tidskriftsartikel (refereegranskat)abstract
- Malignant cells are known to have increased glucose uptake and accelerated glucose metabolism. Using liquid chromatography and mass spectrometry, we found that treatment of acute lymphoblastic leukemia (ALL) cells with the glucocorticoid (GC) dexamethasone (Dex) resulted in profound inhibition of glycolysis. We thus demonstrate that Dex reduced glucose consumption, glucose utilization and glucose uptake by leukemic cells. Furthermore, Dex treatment decreased the levels of the plasma membrane-associated glucose transporter GLUT1, thus revealing the mechanism for the inhibition of glucose uptake. Inhibition of glucose uptake correlated with induction of cell death in ALL cell lines and in leukemic blasts from ALL patients cultured ex vivo. Addition of di-methyl succinate could partially overcome cell death induced by Dex in RS4;11 cells, thereby further supporting the notion that inhibition of glycolysis contributes to the induction of apoptosis. Finally, Dex killed RS4;11 cells significantly more efficiently when cultured in lower glucose concentrations suggesting that modulation of glucose levels might influence the effectiveness of GC treatment in ALL. In summary, our data show that GC treatment blocks glucose uptake by leukemic cells leading to inhibition of glycolysis and that these effects play an important role in the induction of cell death by these drugs.
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
- Fredriksson, A., et al.
(författare)
-
Labeling of human C-peptide by conjugation with N-succinimidyl-4- F-18 fluorobenzoate
- 2001
-
Ingår i: Journal of labelled compounds & radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 44:7, s. 509-519
-
Tidskriftsartikel (refereegranskat)abstract
- We have labeled proinsulin connecting peptide (C-peptide) with fluorine-18 (t(1/2) = 109.7min) in order to perform in vivo biodistribution and pharmacokinetic studies with position emission tomography (PET). This study reports the optimization of the conjugation labeling in the N-terminal with N-succinimidyl-4-[F-18]fluorobenzoate ([F-18]SFB). In preparative runs N-4-[F-18]fluorobenzoyl-C-peptide ([F-18]FB-C-peptide) was produced in 8-12% decay-corrected yields, counted from resolubilized [F-18]F-, in less than 5h. The specific radioactivity of [F-18]FB-C-peptide, determined using ELISA for one of the preparations, was around 70 GBq/mu mol at end of synthesis.
|
|
| 33. |
|
|
| 34. |
|
|
| 35. |
- Giunta, Riccardo E, et al.
(författare)
-
ESPRAS Survey on Breast Reconstruction in Europe. : ESPRAS Umfrage zur Brustrekonstruktion in Europa.
- 2021
-
Ingår i: Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V.... - : Georg Thieme Verlag KG. - 1439-3980. ; 53:4, s. 340-348
-
Tidskriftsartikel (refereegranskat)abstract
- The European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) previously identified the need for harmonisation of breast reconstruction standards in Europe, in order to strengthen the role of plastic surgeons. This study aims to survey the status, current trends and potential regional differences in the practice of breast reconstruction in Europe, with emphasis on equity and access.A largescale web-based questionnaire was sent to consultant plastic and reconstructive surgeons, who are experienced in breast reconstruction and with understanding of the national situation in their country. Suitable participants were identified via the Executive Committee (ExCo) of ESPRAS and national delegates of ESPRAS. The results were evaluated and related to evidence-based literature.A total of 33 participants from 29 European countries participated in this study. Overall, the incidence of breast reconstruction was reported to be relatively low across Europe, comparable to other large geographic regions, such as North America. Equity of provision and access to breast reconstruction was distributed evenly within Europe, with geographic regions potentially affecting the type of reconstruction offered. Standard practices with regard to radiotherapy differed between countries and a clear demand for European guidelines on breast reconstruction was reported.This study identified distinct lack of consistency in international practice patterns across European countries and a strong demand for consistent European guidance. Large-scale and multi-centre European clinical trials are required to further elucidate the presented areas of interest and to define European standard operating procedures.
|
|
| 36. |
- Hagberg, Carolina E, et al.
(författare)
-
Vascular endothelial growth factor B controls endothelial fatty acid uptake.
- 2010
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 464:7290, s. 917-21
-
Tidskriftsartikel (refereegranskat)abstract
- The vascular endothelial growth factors (VEGFs) are major angiogenic regulators and are involved in several aspects of endothelial cell physiology. However, the detailed role of VEGF-B in blood vessel function has remained unclear. Here we show that VEGF-B has an unexpected role in endothelial targeting of lipids to peripheral tissues. Dietary lipids present in circulation have to be transported through the vascular endothelium to be metabolized by tissue cells, a mechanism that is poorly understood. Bioinformatic analysis showed that Vegfb was tightly co-expressed with nuclear-encoded mitochondrial genes across a large variety of physiological conditions in mice, pointing to a role for VEGF-B in metabolism. VEGF-B specifically controlled endothelial uptake of fatty acids via transcriptional regulation of vascular fatty acid transport proteins. As a consequence, Vegfb(-/-) mice showed less uptake and accumulation of lipids in muscle, heart and brown adipose tissue, and instead shunted lipids to white adipose tissue. This regulation was mediated by VEGF receptor 1 and neuropilin 1 expressed by the endothelium. The co-expression of VEGF-B and mitochondrial proteins introduces a novel regulatory mechanism, whereby endothelial lipid uptake and mitochondrial lipid use are tightly coordinated. The involvement of VEGF-B in lipid uptake may open up the possibility for novel strategies to modulate pathological lipid accumulation in diabetes, obesity and cardiovascular diseases.
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
- Lidell, Martin, 1970, et al.
(författare)
-
Evidence for two types of brown adipose tissue in humans
- 2013
-
Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 19:5, s. 631-634
-
Tidskriftsartikel (refereegranskat)abstract
- The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was
|
|
| 41. |
- Lidskog, R., et al.
(författare)
-
COVID-19, the climate, and transformative change : Comparing the social anatomies of crises and their regulatory responses
- 2020
-
Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 12:16
-
Tidskriftsartikel (refereegranskat)abstract
- Despite forces struggling to reduce global warming growing stronger, there has been mixed success in generating substantive policy implementation, while the global spread of the coronavirus has prompted strong and far-reaching governmental responses around the world. This paper addresses the complex and partly contradictory responses to these two crises, investigating their social anatomies. Using temporality, spatiality, and epistemic authority as the main conceptual vehicles, the two crises are systematically compared. Despite sharing a number of similarities, the most striking difference between the two crises is the urgency of action to counter the rapid spread of the pandemic as compared to the slow and meager action to mitigate longstanding, well-documented, and accelerating climate change. Although the tide now seems to have turned towards a quick and massive effort to restore the status quo-including attempts to restart the existing economic growth models, which imply an obvious risk for substantially increasing CO2 emissions-the article finally points at some signs of an opening window of opportunity for green growth and degrowth initiatives. However, these signs have to be realistically interpreted in relation to the broader context of power relations in terms of governance configurations and regulatory strategies worldwide at different levels of society.
|
|
| 42. |
- Manouilenko, Irina, et al.
(författare)
-
Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders
- 2013
-
Ingår i: Research in Autism Spectrum Disorders. - Oxon, United Kingdom : Elsevier. - 1750-9467 .- 1878-0237. ; 7, s. 566-578
-
Tidskriftsartikel (refereegranskat)abstract
- The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “intelligence/motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “intelligence/motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype.
|
|
| 43. |
- Ohlsson, Jonas A., et al.
(författare)
-
SPIRO : the automated Petri plate imaging platform designed by biologists, for biologists
- 2024
-
Ingår i: The Plant Journal. - : John Wiley & Sons. - 0960-7412 .- 1365-313X. ; 118:2, s. 584-600
-
Tidskriftsartikel (refereegranskat)abstract
- Phenotyping of model organisms grown on Petri plates is often carried out manually, despite the procedures being time-consuming and laborious. The main reason for this is the limited availability of automated phenotyping facilities, whereas constructing a custom automated solution can be a daunting task for biologists. Here, we describe SPIRO, the Smart Plate Imaging Robot, an automated platform that acquires time-lapse photographs of up to four vertically oriented Petri plates in a single experiment, corresponding to 192 seedlings for a typical root growth assay and up to 2500 seeds for a germination assay. SPIRO is catered specifically to biologists' needs, requiring no engineering or programming expertise for assembly and operation. Its small footprint is optimized for standard incubators, the inbuilt green LED enables imaging under dark conditions, and remote control provides access to the data without interfering with sample growth. SPIRO's excellent image quality is suitable for automated image processing, which we demonstrate on the example of seed germination and root growth assays. Furthermore, the robot can be easily customized for specific uses, as all information about SPIRO is released under open-source licenses. Importantly, uninterrupted imaging allows considerably more precise assessment of seed germination parameters and root growth rates compared with manual assays. Moreover, SPIRO enables previously technically challenging assays such as phenotyping in the dark. We illustrate the benefits of SPIRO in proof-of-concept experiments which yielded a novel insight on the interplay between autophagy, nitrogen sensing, and photoblastic response.
|
|
| 44. |
- Olofsson Bagge, Roger, et al.
(författare)
-
Isolated Hepatic Perfusion With Melphalan for Patients With Isolated Uveal Melanoma Liver Metastases : A Multicenter, Randomized, Open-Label, Phase III Trial (the SCANDIUM Trial)
- 2023
-
Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 41:16, s. 3042-3050
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: About half of patients with metastatic uveal melanoma present with isolated liver metastasis, in whom the median survival is 6-12 months. The few systemic treatment options available only moderately prolong survival. Isolated hepatic perfusion (IHP) with melphalan is a regional treatment option, but prospective efficacy and safety data are lacking.METHODS: In this multicenter, randomized, open-label, phase III trial, patients with previously untreated isolated liver metastases from uveal melanoma were randomly assigned to receive a one-time treatment with IHP with melphalan or best alternative care (control group). The primary end point was overall survival at 24 months. Here, we report the secondary outcomes of response according to RECIST 1.1 criteria, progression-free survival (PFS), hepatic PFS (hPFS), and safety.RESULTS: Ninety-three patients were randomly assigned, and 87 patients were assigned to either IHP (n = 43) or a control group receiving the investigator's choice of treatment (n = 44). In the control group, 49% received chemotherapy, 39% immune checkpoint inhibitors, and 9% locoregional treatment other than IHP. In an intention-to-treat analysis, the overall response rates (ORRs) were 40% versus 4.5% in the IHP and control groups, respectively (P < .0001). The median PFS was 7.4 months versus 3.3 months (P < .0001), with a hazard ratio of 0.21 (95% CI, 0.12 to 0.36), and the median hPFS was 9.1 months versus 3.3 months (P < .0001), both favoring the IHP arm. There were 11 treatment-related serious adverse events in the IHP group compared with seven in the control group. There was one treatment-related death in the IHP group.CONCLUSION: IHP treatment resulted in superior ORR, hPFS, and PFS compared with best alternative care in previously untreated patients with isolated liver metastases from primary uveal melanoma.
|
|
| 45. |
|
|
| 46. |
- Pagani, Marco, et al.
(författare)
-
Brief Report : alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ
- 2012
-
Ingår i: Journal of autism and developmental disorders. - New York, USA : Springer. - 0162-3257 .- 1573-3432. ; 42:2, s. 313-318
-
Tidskriftsartikel (refereegranskat)abstract
- Specific biological markers for autism spectrum disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal "social" brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-(11)C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD.
|
|
| 47. |
- Rakityansky, S. A., et al.
(författare)
-
A METHOD FOR EXTRACTING THE RESONANCE PARAMETERS FROM EXPERIMENTAL CROSS-SECTIONS
- 2013
-
Ingår i: International Journal of Modern Physics E. - 0218-3013. ; 22:5, s. UNSP 1350032-
-
Tidskriftsartikel (refereegranskat)abstract
- Within the proposed method, a set of experimental data points are fitted using a multi-channel S-matrix. Then the resonance parameters are located as its poles on an appropriate sheet of the Riemann surface of the energy. The main advantage of the method is that the S-matrix is constructed in such a way that it has proper analytic structure, i.e. for any number of two-body channels, the branching at all the channel thresholds is represented via exact analytic expressions in terms of the channel momenta. The way the S-matrix is constructed makes it possible not only to locate multi-channel resonances but also to extract their partial widths as well as to obtain the scattering cross-section in the channels for which no data are available. The efficiency of the method is demonstrated by two model examples of a single-channel and a two-channel problems, where known resonance parameters are rather accurately reproduced by fitting the pseudo-data artificially generated using the corresponding potentials.
|
|
| 48. |
- Rakityansky, S. A., et al.
(författare)
-
Analytic structure and power series expansion of the Jost function for the two-dimensional problem
- 2012
-
Ingår i: Journal of Physics A. - : IOP Publishing. - 1751-8113 .- 1751-8121. ; 45:13, s. 135209-
-
Tidskriftsartikel (refereegranskat)abstract
- For a two-dimensional quantum-mechanical problem, we obtain a generalized power series expansion of the S-matrix that can be done near an arbitrary point on the Riemann surface of the energy, similar to the standard effective-range expansion. In order to do this, we consider the Jost function and analytically factorize its momentum dependence that causes the Jost function to be a multi-valued function. The remaining single-valued function of the energy is then expanded in the power series near an arbitrary point in the complex energy plane. A systematic and accurate procedure has been developed for calculating the expansion coefficients. This makes it possible to obtain a semi-analytic expression for the Jost function (and therefore for the S-matrix) near an arbitrary point on the Riemann surface and use it, for example, to locate the spectral points (bound and resonant states) as the S-matrix poles. The method is applied to a model similar to those used in the theory of quantum dots.
|
|
| 49. |
- Rakityansky, S. A., et al.
(författare)
-
Analytic Structure and Power-Series Expansion of the Jost Matrix
- 2013
-
Ingår i: Few-body systems. - : Springer Science and Business Media LLC. - 0177-7963 .- 1432-5411. ; 54:5-6, s. 673-683
-
Tidskriftsartikel (refereegranskat)abstract
- For the Jost-matrix that describes the multi-channel scattering, the momentum dependencies at all the branching points on the Riemann surface are factorized analytically. The remaining single-valued matrix functions of the energy are expanded in the power-series near an arbitrary point in the complex energy plane. A systematic and accurate procedure has been developed for calculating the expansion coefficients. This makes it possible to obtain an analytic expression for the Jost-matrix (and therefore for the S-matrix) near an arbitrary point on the Riemann surface (within the domain of its analyticity) and thus to locate the resonant states as the S-matrix poles. This approach generalizes the standard effective-range expansion that now can be done not only near the threshold, but practically near an arbitrary point on the Riemann surface of the energy. Alternatively, The semi-analytic (power-series) expression of the Jost matrix can be used for extracting the resonance parameters from experimental data. In doing this, the expansion coefficients can be treated as fitting parameters to reproduce experimental data on the real axis (near a chosen center of expansion E (0)) and then the resulting semi-analytic matrix S(E) can be used at the nearby complex energies for locating the resonances. Similarly to the expansion procedure in the three-dimensional space, we obtain the expansion for the Jost function describing a quantum system in the space of two dimensions (motion on a plane), where the logarithmic branching point is present.
|
|
| 50. |
- Rakityansky, S. A., et al.
(författare)
-
Generalized effective-range expansion
- 2009
-
Ingår i: Journal of Physics A. - : IOP Publishing. - 1751-8113 .- 1751-8121. ; 42:22, s. 225302-
-
Tidskriftsartikel (refereegranskat)abstract
- A systematic and accurate procedure has been developed for calculating the coefficients phi((in/out))(ln) of the series expansion f(l)((in/out))(k) = Sigma(infinity)(n=0)(k-k(0))(n) phi((in/out))(ln) of the Jost functions in the vicinity of an arbitrary point k(0) in the complex momentum plane. This makes it possible to obtain an analytic expression for the S-matrix s(l)(k) = f(l)((out))(k)/f(l)((in))(k) around k(0) and locate its possible poles. In the particular case of l = 0 and k(0) = 0, any number of the parameters of the standard effective-range expansion k cot delta(0) = -1/a + r(0)k(2)/2 - ... are easily obtained using the corresponding coefficients phi((in/out))(ln). Numerical examples demonstrate the stability and accuracy of the proposed method.
|
|
