| 1. |
- Elander, N, et al.
(författare)
-
Microwave-enhanced radiochemistry
- 2000
-
Ingår i: CHEMICAL SOCIETY REVIEWS. - : Royal Society of Chemistry (RSC). - 0306-0012 .- 1460-4744. ; 29:4, s. 239-249
-
Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
|
|
| 2. |
- Elander, N. O., et al.
(författare)
-
Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer
- 2018
-
Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 118:7, s. 947-954
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Dihydropyrimidine dehydrogenase (DPD) tumour expression may provide added value to human equilibrative nucleoside transporter-1 (hENT1) tumour expression in predicting survival following pyrimidine-based adjuvant chemotherapy.Methods: DPD and hENT1 immunohistochemistry and scoring was completed on tumour cores from 238 patients with pancreatic cancer in the ESPAC-3(v2) trial, randomised to either postoperative gemcitabine or 5-fluorouracil/folinic acid (5FU/FA).Results: DPD tumour expression was associated with reduced overall survival (hazard ratio, HR = 1.73 [95% confidence interval, CI = 1.21-2.49], p = 0.003). This was significant in the 5FU/FA arm (HR = 2.07 [95% CI = 1.22-3.53], p = 0.007), but not in the gemcitabine arm (HR = 1.47 [0.91-3.37], p = 0.119). High hENT1 tumour expression was associated with increased survival in gemcitabine treated (HR = 0.56 [0.38-0.82], p = 0.003) but not in 5FU/FA treated patients (HR = 1.19 [0.80-1.78], p = 0.390). In patients with low hENT1 tumour expression, high DPD tumour expression was associated with a worse median [95% CI] survival in the 5FU/FA arm (9.7 [5.3-30.4] vs 29.2 [19.5-41.9] months, p = 0.002) but not in the gemcitabine arm (14.0 [9.1-15.7] vs. 18.0 [7.6-15.3] months, p = 1.000). The interaction of treatment arm and DPD expression was not significant (p = 0.303), but the interaction of treatment arm and hENT1 expression was (p = 0.009).Conclusion: DPD tumour expression was a negative prognostic biomarker. Together with tumour expression of hENT1, DPD tumour expression defined patient subgroups that might benefit from either postoperative 5FU/FA or gemcitabine.
|
|
| 3. |
- Elander, N. O., et al.
(författare)
-
Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy
- 2018
-
Ingår i: British Journal of Cancer. - : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 118:8, s. 1084-1088
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Deoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma.METHODS: Immunohistochemical staining of DCTD and RRM1 was performed on tissue microarrays representing tumour samples from 303 patients in European Study Group for Pancreatic Cancer (ESPAC)-randomised adjuvant trials following pancreatic resection, 272 of whom had received gemcitabine or 5-fluorouracil with folinic acid in ESPAC-3(v2), and 31 patients from the combined ESPAC-3(v1) and ESPAC-1 post-operative pure observational groups.RESULTS: Neither log-rank testing on dichotomised strata or Cox proportional hazard regression showed any relationship of DCTD or RRM1 expression levels to survival overall or by treatment group.CONCLUSIONS: Expression of either DCTD or RRM1 was not prognostic or predictive in patients with pancreatic adenocarcinoma who had had post-operative chemotherapy with either gemcitabine or 5-fluorouracil with folinic acid.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Kalhori, S, et al.
(författare)
-
A re-entrant cavity for microwave-enhanced chemistry
- 2003
-
Ingår i: The Journal of microwave power and electromagnetic energy : a publication of the International Microwave Power Institute. - : Informa UK Limited. - 0832-7823. ; 38:2, s. 125-135
-
Tidskriftsartikel (refereegranskat)
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Semb, G, et al.
(författare)
-
Erratum
- 2017
-
Ingår i: Journal of plastic surgery and hand surgery. - 2000-6764. ; 51:2, s. 158-158
-
Tidskriftsartikel (refereegranskat)
|
|
| 10. |
|
|
| 11. |
- Stone-Elander, S, et al.
(författare)
-
Microwaving in F-18 chemistry: quirks and tweaks
- 2007
-
Ingår i: Ernst Schering Research Foundation workshop. - : Springer Berlin Heidelberg. - 0947-6075. ; :62, s. 243-69
-
Tidskriftsartikel (refereegranskat)
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
- Carlsund-Levin, Christina, et al.
(författare)
-
An exterior complex rotated coupled channel description of predissociation in diatomic molecules applied to a model of the four lowest (2)Sigma(+)-states in CaH
- 2002
-
Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; 65:4, s. 306-322
-
Tidskriftsartikel (refereegranskat)abstract
- The exterior complex rotated Coupled-Channel formulation of potential scattering makes it possible to calculate energies and widths for a non-adiabatic model of a diatomic molecule or quasimolecule, The structure and decay pattern of a diatomic system is in this way described in a non-perturbative way. In this contribution we use the non-adiabatic form of an empirically derived potential energy curve matrix, previously used by Martin, J. Chem. Phys. 88, 1997 (1988) [1], for the four lowest (2)Sigma(+)-states of the CaH radical to demonstrate how one can calculate term positions as well as non-radiative decay widths in a realistic case for a large range of rovibronic levels. The differences between the previously derived Born-Oppenheimer term values [1] and the present non-adiabatic results are discussed and compared with previous work.
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
- Giunta, RE, et al.
(författare)
-
Correction: ESPRAS Survey: National and European Societies for Plastic Surgeons
- 2024
-
Ingår i: Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V.... - 1439-3980. ; 56:2, s. e2-
-
Tidskriftsartikel (refereegranskat)
|
|
| 23. |
- Giunta, R. E., et al.
(författare)
-
Strengthening Plastic Surgery in Europe - ESPRAS Survey at ESPRAS European Leadership Forum (ELF)
- 2021
-
Ingår i: Handchirurgie Mikrochirurgie Plastische Chirurgie. - : Georg Thieme Verlag KG. - 0722-1819 .- 1439-3980. ; 53:2, s. 102-109
-
Tidskriftsartikel (refereegranskat)abstract
- Background â The Executive Committee (ExCo) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) organized a first ESPRAS European Leadership Forum (ELF) to facilitate international exchange and to provide a platform for international leaders and delegates of national societies of Plastic Surgery to discuss common challenges. The presented manuscript presents key findings in a first effort of international harmonization and cooperation. Materials and Methods â Members of the executive (presidents, vice-presidents, secretary generals) and national delegates of Plastic Surgery national societies discussed hot topics in Plastic Surgery via the Zoom virtual conferencing system (Zoom Video Communications, Inc.). Attending participants responded to a virtual question & answer session with questions being displayed throughout the webinar. Results â The challenges associated with Aesthetic Surgery performed by doctors who are not board-certified Plastic Surgeons and Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) were perceived as major hot topics within most national societies. Both topics were discussed vividly. Education in plastic surgery and a European fellowship program for young Plastic Surgeons was favored by a large majority of participants. The implementation of European registries for free flaps, implants and for breast reconstruction were supported by the majority of respondents. Conclusion â The ESPRAS ELF provides a platform to propel international exchange and alliance, communication, education, research and future projects. A further virtual webinar with the topic Strategies for Strengthening and Defending Plastic Surgery against Others was suggested to be conducted in spring 2021. © 2020 Lippincott Williams and Wilkins. All rights reserved.
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
- Lindberg, E., et al.
(författare)
-
Psychotherapy in rheumatoid arthritis : A parallel-process study of psychic state and course of rheumatic disease
- 1996
-
Ingår i: Zeitschrift für Rheumatologie. - 0301-6382. ; 55:1, s. 28-39
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, well-known psychosomatic (psychoneuroimmunological) connections have been used for therapeutic purposes. Fifteen patients with rheumatoid arthritis (RA) were treated with analytical insight therapy for 60-90 min weekly during 10 months to 4.5 years (median 3.3 years). Six patients showed great and largely continuous improvement, both psychic and physical, throughout the period of psychotherapy and often for a long time thereafter. In another five cases, improvements in psychic state and the joint disease took place over a period of 1-2 years. Later, when the emotional channels to childhood traumata were opened, these five patients relapsed and the course of their disease became more variable. In four cases, the connections between psychic state and the course of the joint disease were more varied throughout the period of psychotherapy. In the studied group the correlation between psychic state and course of rheumatic disease was highly significant. The probability of the outcome of the study being due to chance alone is considered very small, especially taking into account the fact that RA is a chronic progressive disease.
|
|
| 28. |
- Ohlsson, Jonas A., et al.
(författare)
-
SPIRO : the automated Petri plate imaging platform designed by biologists, for biologists
- 2024
-
Ingår i: The Plant Journal. - : John Wiley & Sons. - 0960-7412 .- 1365-313X. ; 118:2, s. 584-600
-
Tidskriftsartikel (refereegranskat)abstract
- Phenotyping of model organisms grown on Petri plates is often carried out manually, despite the procedures being time-consuming and laborious. The main reason for this is the limited availability of automated phenotyping facilities, whereas constructing a custom automated solution can be a daunting task for biologists. Here, we describe SPIRO, the Smart Plate Imaging Robot, an automated platform that acquires time-lapse photographs of up to four vertically oriented Petri plates in a single experiment, corresponding to 192 seedlings for a typical root growth assay and up to 2500 seeds for a germination assay. SPIRO is catered specifically to biologists' needs, requiring no engineering or programming expertise for assembly and operation. Its small footprint is optimized for standard incubators, the inbuilt green LED enables imaging under dark conditions, and remote control provides access to the data without interfering with sample growth. SPIRO's excellent image quality is suitable for automated image processing, which we demonstrate on the example of seed germination and root growth assays. Furthermore, the robot can be easily customized for specific uses, as all information about SPIRO is released under open-source licenses. Importantly, uninterrupted imaging allows considerably more precise assessment of seed germination parameters and root growth rates compared with manual assays. Moreover, SPIRO enables previously technically challenging assays such as phenotyping in the dark. We illustrate the benefits of SPIRO in proof-of-concept experiments which yielded a novel insight on the interplay between autophagy, nitrogen sensing, and photoblastic response.
|
|
| 29. |
- Olofsson Bagge, Roger, 1978, et al.
(författare)
-
Isolated Hepatic Perfusion With Melphalan for Patients With Isolated Uveal Melanoma Liver Metastases: A Multicenter, Randomized, Open-Label, Phase III Trial (the SCANDIUM Trial)
- 2023
-
Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 41:16, s. 3042-50
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSEAbout half of patients with metastatic uveal melanoma present with isolated liver metastasis, in whom the median survival is 6-12 months. The few systemic treatment options available only moderately prolong survival. Isolated hepatic perfusion (IHP) with melphalan is a regional treatment option, but prospective efficacy and safety data are lacking.METHODSIn this multicenter, randomized, open-label, phase III trial, patients with previously untreated isolated liver metastases from uveal melanoma were randomly assigned to receive a one-time treatment with IHP with melphalan or best alternative care (control group). The primary end point was overall survival at 24 months. Here, we report the secondary outcomes of response according to RECIST 1.1 criteria, progression-free survival (PFS), hepatic PFS (hPFS), and safety.RESULTSNinety-three patients were randomly assigned, and 87 patients were assigned to either IHP (n = 43) or a control group receiving the investigator's choice of treatment (n = 44). In the control group, 49% received chemotherapy, 39% immune checkpoint inhibitors, and 9% locoregional treatment other than IHP. In an intention-to-treat analysis, the overall response rates (ORRs) were 40% versus 4.5% in the IHP and control groups, respectively (P < .0001). The median PFS was 7.4 months versus 3.3 months (P < .0001), with a hazard ratio of 0.21 (95% CI, 0.12 to 0.36), and the median hPFS was 9.1 months versus 3.3 months (P < .0001), both favoring the IHP arm. There were 11 treatment-related serious adverse events in the IHP group compared with seven in the control group. There was one treatment-related death in the IHP group.CONCLUSIONIHP treatment resulted in superior ORR, hPFS, and PFS compared with best alternative care in previously untreated patients with isolated liver metastases from primary uveal melanoma.
|
|
| 30. |
|
|
| 31. |
- Rakityansky, S. A., et al.
(författare)
-
Pade approximation of the S-matrix as a way of locating quantum resonances and bound states
- 2007
-
Ingår i: J PHYS A-MATH THEOR. - : IOP Publishing. - 1751-8113. ; 40:49, s. 14857-14869
-
Tidskriftsartikel (refereegranskat)abstract
- It is shown that the spectral points (bound states and resonances) generated by a central potential of a single-channel problem, can be found using rational parametrization of the S-matrix. To achieve this, one only needs values of the S-matrix along the real positive energy axis. No calculations of the S-matrix at complex energies or a complex rotation are necessary. The proposed method is therefore universal in that it is applicable to any potential (local, non-local, discontinuous, etc) provided that there is a way of obtaining the S-matrix (or scattering phase shifts) at real collision energies. Besides this, combined with any method that extracts the phase shifts from the scattering data, the proposed rational parametrization technique would be able to do the spectral analysis using the experimental data.
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
|
|
