| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 3. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 4. |
- Zhou, Bin, et al.
(författare)
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Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants
- 2016
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Ingår i: The Lancet. - : Elsevier B.V.. - 0140-6736 .- 1474-547X. ; 387:10027, s. 1513-1530
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Tidskriftsartikel (refereegranskat)abstract
- Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes.Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue.Findings: We used data from 751 studies including 4372000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-17.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target.Interpretation: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults aff ected, has increased faster in low-income and middle-income countries than in high-income countries.
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| 5. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 6. |
- Eeraerts, Maxime, et al.
(författare)
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Synthesis of highbush blueberry pollination research reveals region-specific differences in the contributions of honeybees and wild bees
- 2023
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Ingår i: Journal of Applied Ecology. - 0021-8901. ; 60:12, s. 2528-2539
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Forskningsöversikt (refereegranskat)abstract
- Highbush blueberry production has expanded worldwide in recent decades. To safeguard future yields, it is essential to understand if insect pollination is limiting current blueberry production and which insects contribute to pollination in different production regions. We present a systematic review including a set of meta-analyses on insect-mediated pollination in highbush blueberry. We summarize the geographic distribution of research, the abundance of different pollinator taxa and their relative pollination contributions. Using raw data from 21 studies, totalling 496 site replicates, we determine the degree of pollination service and pollen limitation (i.e. combining open pollination levels with experimental bagged and/or hand pollination treatments), as well as the contribution of honeybees and wild bees to pollination (i.e. observational, open pollination). Most studies originate from North America, focusing on only a few cultivars. Honeybees are the dominant pollinator, and wild bees are occasionally abundant. Wild bees are more efficient pollinators on a single-visit basis compared to honeybees, which increases their relative pollination contribution compared to their relative abundance. Insect-mediated pollination services increased blueberry fruit set, berry weight and seed set (R2 values: 64.8%, 75.9% and 75.2% respectively). We often detected pollen limitation, indicated by an increase in fruit set, berry weight and seed set (R2: 10.1%, 18.2% and 21.5%, respectively), with additional hand pollination. Increasing visitation of honeybees and wild bees contributed to blueberry pollination by increasing fruit set (R2: 5.4% and 3.5%), berry weight (R2: 6.5% and 2.8%) and seed set (R2: 6.4% and 3.8%) respectively. Bee contributions to fruit set and berry weight were variable across regions. Synthesis and application: A diverse community of insects, primarily bees, contributes to highbush blueberry pollination and yield. However, pollination deficits are common. The finding that both honeybees and wild bees enhance pollination highlights the possibility of adopting different management strategies that utilize honeybees, wild bees or both depending on the specific context and region. This further emphasizes the general importance of conserving pollinator health and diversity. Our synthesis highlights data gaps and areas for future research to better understand the pollination contribution of different pollinators to crops that are expanding globally.
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| 7. |
- Ellis, Rachel, et al.
(författare)
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Benefit from, and acclimatization to, frequency compression hearing aids in experienced adult hearing-aid users
- 2015
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Ingår i: International Journal of Audiology. - : Informa Healthcare. - 1499-2027 .- 1708-8186. ; 54:1, s. 37-47
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim was to investigate whether frequency compression (FC) hearing aids provide additional benefit to that conferred by conventional amplification. Design: Participants wore the same hearing aid with FC enabled and disabled for six weeks (ABA design) in each condition. Speech recognition tests (in both quiet and in noise) were administered alongside two questionnaires. Performance was compared across the two signal processing conditions and at different time points. Study sample: Twelve experienced hearing-aid users (aged 65-84 years old) with moderate-to-severe high-frequency hearing loss participated in the study. Results: FC resulted in statistically significantly higher mean scores in all of the administered speech tests. Improvements over time were limited to high frequency phoneme perception. No effect of FC on self-report outcomes was observed. Conclusions: FC may lead to significant improvements in speech perception outcomes in both quiet and noise for many individuals. No participant was significantly disadvantaged by the use of FC.
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| 8. |
- Ellis, Rachel, et al.
(författare)
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Cognition and Speech-In-Noise Recognition: The Role of Proactive Interference
- 2014
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Ingår i: JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY. - : American Academy of Audiology. - 1050-0545 .- 2157-3107. ; 25:10, s. 975-982
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Tidskriftsartikel (refereegranskat)abstract
- Background: Complex working memory (WM) span tasks have been shown to predict speech-in-noise (SIN) recognition. Studies of complex WM span tasks suggest that, rather than indexing a single cognitive process, performance on such tasks may be governed by separate cognitive subprocesses embedded within WM. Previous research has suggested that one such subprocess indexed by WM tasks is proactive interference (PI), which refers to difficulties memorizing current information because of interference from previously stored long-term memory representations for similar information. Purpose: The aim of the present study was to investigate phonological PI and to examine the relationship between PI (semantic and phonological) and SIN perception. Research Design: A within-subjects experimental design was used. Study Sample: An opportunity sample of 24 young listeners with normal hearing was recruited. Data Collection and Analysis: Measures of resistance to, and release from, semantic and phonological PI were calculated alongside the signal-to-noise ratio required to identify 50% of keywords correctly in a SIN recognition task. The data were analyzed using t-tests and correlations. Results: Evidence of release from and resistance to semantic interference was observed. These measures correlated significantly with SIN recognition. Limited evidence of phonological PI was observed. Conclusions: The results show that capacity to resist semantic PI can be used to predict SIN recognition scores in young listeners with normal hearing. On the basis of these findings, future research will focus on investigating whether tests of PI can be used in the treatment and/or rehabilitation of hearing loss.
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| 9. |
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| 10. |
- Ellis, Rachel, et al.
(författare)
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Combined effects of age and hearing impairment on utterances and requests for clarification in spontaneous conversation and a referential communication task
- 2024
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Ingår i: International journal of language and communication disorders. - : WILEY. - 1368-2822 .- 1460-6984. ; 59:1, s. 293-303
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe impact of hearing impairment is typically studied in terms of its effects on speech perception, yet this fails to account for the interactive nature of communication. Recently, there has been a move towards studying the effects of age-related hearing impairment on interaction, often using referential communication tasks; however, little is known about how interaction in these tasks compares to everyday communication. AimsTo investigate utterances and requests for clarification used in one-to-one conversations between older adults with hearing impairment and younger adults without hearing impairment, and between two younger adults without hearing impairment. Methods & ProceduresA total of 42 participants were recruited to the study and split into 21 pairs, 10 with two younger adults without hearing impairment and 11 with one younger adult without hearing impairment and one older participant with age-related hearing impairment (hard of hearing). Results from three tasks-spontaneous conversation and two trials of a referential communication task-were compared. A total of 5 min of interaction in each of the three tasks was transcribed, and the frequency of requests for clarification, mean length of utterance and total utterances were calculated for individual participants and pairs. Outcomes & ResultsWhen engaging in spontaneous conversation, participants made fewer requests for clarification than in the referential communication, regardless of hearing status/age (p & LE; 0.012). Participants who were hard of hearing made significantly more requests for clarification than their partners without hearing impairment in only the second trial of the referential communication task (U = 25, p = 0.019). Mean length of utterance was longer in spontaneous conversation than in the referential communication task in the pairs without hearing impairment (p & LE; 0.021), but not in the pairs including a person who was hard of hearing. However, participants who were hard of hearing used significantly longer utterances than their partners without hearing impairment in the spontaneous conversation (U = 8, p < 0.001) but not in the referential communication tasks. Conclusions & ImplicationsThe findings suggest that patterns of interaction observed in referential communication tasks differ to those observed in spontaneous conversation. The results also suggest that fatigue may be an important consideration when planning studies of interaction that use multiple conditions of a communication task, particularly when participants are older or hard of hearing. WHAT THIS PAPER ADDSWhat is already known on this subjectAge-related hearing impairment is known to affect communication; however, the majority of studies have focused on its impact on speech perception in controlled conditions. This indicates little about the impact on everyday, interactive, communication. What this study adds to the existing knowledgeWe investigated utterance length and requests for clarification in one-to-one conversations between pairs consisting of one older adult who is hard of hearing and one younger adult without hearing impairment, or two younger adults without hearing impairment. Results from three tasks (two trials of a referential communication task and spontaneous conversation) were compared. The findings demonstrated a significant effect of task type on requests for clarification in both groups. Furthermore, in spontaneous conversation, older adults who were hard of hearing used significantly longer utterances than their partners without hearing impairment. This pattern was not observed in the referential communication task. What are the potential or actual clinical implications of this work?These findings have important implications for generalizing results from controlled communication tasks to more everyday conversation. Specifically, they suggest that the previously observed strategy of monopolizing conversation, possibly as an attempt to control it, may be more frequently used by older adults who are hard of hearing in natural conversation than in a more contrived communication task.
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| 11. |
- Ellis, Rachel, et al.
(författare)
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Does susceptibility to proactive interference predict hearing aid benefit?
- 2014
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Konferensbidrag (refereegranskat)abstract
- Proactive Interference refers to an effect whereby previously learned information interferes with the capacity to learn new information. It has been suggested that performance on complex tests of working memory may be heavily influenced by susceptibility to proactive inteference (Kane and Engle, 2000). There is a wealth of evidence linking performance in complex working memory tasks to speech-in-noise recognition by listeners with normal hearing and those with a hearing loss in both aided and unaided conditions (see Akeroyd, 2008 for a review). Previous research has shown that susceptibility to proactive interference can be used to predict speech-in-noise recognition in young listeners with normal hearing (Ellis and Rönnberg, in press). We will report results that show whether this finding can be replicated in older adults with hearing loss and whether susceptibility to proactive interference can be used to predict the degree to which hearing aid use improves speech-in-noise recognition in these listeners. Potential clinical implications relating to the use of tests of proactive interference in the hearing aid fitting and rehabilitation processes will be discussed.References:Akeroyd, M.A. (2008) Are individual differences in speech reception related to individual differences in cognitive ability? A survey of twenty experimental studies with normal and hearing-impaired adults. International Journal of Audiology, 47, s53-s71.Ellis, R. J. and Rönnberg, J. (in press) Cognition and speech-in-noise recognition: The role of proactive interference. Journal of the American Academy of AudiologyKane, M.J. & Engle, R.W. (2000) Working-memory capacity, proactive interference and divided attention: Limits on long-term memory retrieval. Journal of Experimental Psychology: Learning, Memory and Cognition, 26, 336-358.
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| 12. |
- Ellis, Rachel, et al.
(författare)
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How does susceptibility to proactive interference relate to speech recognition in aided and unaided conditions?
- 2015
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Ingår i: Frontiers in Psychology. - : Frontiers. - 1664-1078. ; 6:1017
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Tidskriftsartikel (refereegranskat)abstract
- Proactive interference (PI) is the capacity to resist interference to the acquisition of new memories from information stored in the long-term memory. Previous research has shown that PI correlates significantly with the speech-in-noise recognition scores of younger adults with normal hearing. In this study, we report the results of an experiment designed to investigate the extent to which tests of visual PI relate to the speech-in-noise recognition scores of older adults with hearing loss, in aided and unaided conditions. The results suggest that measures of PI correlate significantly with speech-in-noise recognition only in the unaided condition. Furthermore the relation between PI and speech-in-noise recognition differs to that observed in younger listeners without hearing loss. The findings suggest that the relation between PI tests and the speech-in-noise recognition scores of older adults with hearing loss relates to capability of the test to index cognitive flexibility.
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| 13. |
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| 14. |
- Ellis, Rachel J., et al.
(författare)
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Does cognitive function predict frequency compressed speech recognition in listeners with normal hearing and normal cognition?
- 2013
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Ingår i: International Journal of Audiology. - : Informa Healthcare. - 1499-2027 .- 1708-8186. ; 52:1, s. 14-22
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Tidskriftsartikel (refereegranskat)abstract
- Objective:The aim was to investigate the relationship between cognitive ability and frequency compressed speech recognition in listeners with normal hearing and normal cognition. Design:Speech-in-noise recognition was measured using Institute of Electrical and Electronic Engineers sentences presented over earphones at 65 dB SPL and a range of signal-to-noise ratios. There were three conditions:unprocessed, and at frequency compression ratios of 2:1 and 3:1 (cut-off frequency, 1.6 kHz). Working memory and cognitive ability were measured using the reading span test and the trail making test, respectively. Study sample:Participants were 15 young normally-hearing adults with normal cognition. Results:There was a statistically significant reduction in mean speech recognition from around 80% when unprocessed to 40% for 2:1 compression and 30% for 3:1 compression. There was a statistically significant relationship between speech recognition and cognition for the unprocessed condition but not for the frequency-compressed conditions. Conclusions:The relationship between cognitive functioning and recognition of frequency compressed speech-in-noise was not statistically significant. The findings may have been different if the participants had been provided with training and/or time to acclimatize to the frequency-compressed conditions.
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| 15. |
- Ellis, Rachel J, et al.
(författare)
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Predictors of aided speech recognition, with and without frequency compression, in older adults.
- 2015
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Ingår i: International Journal of Audiology. - : Taylor & Francis. - 1499-2027 .- 1708-8186. ; 54:7, s. 467-75
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The aim was to investigate whether cognitive and/or audiological measures predict aided speech recognition, both with and without frequency compression (FC).DESIGN: Participants wore hearing aids, with and without FC for a total of 12 weeks (six weeks in each signal processing condition, ABA design). Performance on a sentence-in-noise recognition test was assessed at the end of each six-week period. Audiological (severity of high frequency hearing loss, presence of dead regions) and cognitive (reading span and trail making test scores) measures were obtained and assessed as predictors of sentence-in-noise recognition with and without FC enabled.STUDY SAMPLE: Twelve experienced hearing-aid users (aged 65-84 years old) with moderate-to-severe high-frequency hearing loss took part in the study.RESULTS: The results suggest that both auditory and cognitive factors can be predictive of sentence-in-noise recognition with conventional amplification. However, only auditory factors were significantly correlated with the degree of benefit obtained from FC.CONCLUSIONS: The strongest predictor of aided speech recognition, both with and without FC, was high frequency hearing loss. Cognitive performance was also a predictor of benefit from conventional amplification, but not of additional benefit from the use of FC.
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| 16. |
- Ellis, Rachel, et al.
(författare)
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Predicting speech-in-noise perception using the trail making task: Results from a large-scale internet study
- 2015
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Konferensbidrag (refereegranskat)abstract
- The purpose of this study was to investigate the utility of an internet-based version of the trail making test (TMT) to predict performance on a speech-in-noise perception task. Computerised versions of the tests were completed, via the internet, by a large (1500+) sample of listeners aged between 18 and 91 years old, both with and without hearing loss. The results show that better performance on both the simple and complex versions of the TMT are associated with better speech-in-noise recognition scores. The findings suggest that the relation between performance in the TMT and speech recognition test may be due to the capacity of the TMT to index perceptual speed, as opposed to the more complex cognitive abilities also implicated in TMT performance.
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| 17. |
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| 18. |
- Ellis, Rachel, et al.
(författare)
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Predicting Speech-in-Noise Recognition from Performance on the Trail Making Test: Results from a Large-Scale Internet Study
- 2016
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Ingår i: Ear and Hearing. - : Lippincott Williams & Wilkins. - 0196-0202 .- 1538-4667. ; 37:1, s. 73-79
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of the study was to investigate the utility of an internet-based version of the trail making test (TMT) to predict performance on a speech-in-noise perception task.Design: Data were taken from a sample of 1509 listeners aged between 18 and 91 years old. Participants completed computerized versions of the TMT and an adaptive speech-in-noise recognition test. All testing was conducted via the internet.Results: The results indicate that better performance on both the simple and complex subtests of the TMT are associated with better speech-in-noise recognition scores. Thirty-eight percent of the participants had scores on the speech-in-noise test that indicated the presence of a hearing loss.Conclusions: The findings suggest that the TMT may be a useful tool in the assessment, and possibly the treatment, of speech-recognition difficulties. The results indicate that the relation between speech-in-noise recognition and TMT performance relates both to the capacity of the TMT to index processing speed and to the more complex cognitive abilities also implicated in TMT performance.
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| 19. |
- Ellis, Rachel, et al.
(författare)
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Proactive interference and speech-in-noise recognition by listeners with normal hearing
- 2013
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Complex working memory capacity (WMC) span tasks have been shown to predict aided and unaided speech in noise recognition (see Akeroyd, 2008 for a review). Studies of complex WMC span tasks suggest that rather than indexing a single cognitive process, performance on such tasks may be governed by separate cognitive subprocesses embedded within WMC (see for example, Sörqvist, Ljungberg, & Ljung, 2010). Thus, the predictive relationship between scores on complex WMC span tasks and the perception of speech-in-noise may not due to WMC per se, but rather to one or more of the component processes that WMC tasks may index. Previous research has suggested that subprocesses may include executive functioning (Whitney et al., 2001) and resistance to proactive interference (Kane and Engle, 2000). Proactive interference (PI) refers to difficulties memorizing current information due to interference from previously stored long-term memory representations for similar information. Although PI is typically investigated in relation to semantic interference, the present research aims to examine PI caused by differences in phonological representations, similar to those caused by a hearing loss or different signal processing methods. The results of a study conducted to investigate the relationship between these cognitive processes and the speech in noise recognition scores of listeners with normal hearing will be presented.
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| 20. |
- Ellis, Rachel, et al.
(författare)
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Temporal fine structure: associations with cognition and speech-in-noise recognition in adults with normal hearing or hearing impairment
- 2022
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Ingår i: International Journal of Audiology. - : Taylor & Francis Ltd. - 1499-2027 .- 1708-8186. ; 61:9, s. 778-786
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To investigate associations between sensitivity to temporal fine structure (TFS) and performance in cognitive and speech-in-noise recognition tests. Design A binaural test of TFS sensitivity (the TFS-LF) was used. Measures of cognition included the reading span, Ravens, and text-reception threshold tests. Measures of speech recognition included the Hearing in noise (HINT) and the Hagerman matrix sentence tests in three signal processing conditions. Study sample Analyses are based on the performance of 324/317 adults with and without hearing impairment. Results Sensitivity to TFS was significantly correlated with both the reading span test and the recognition of speech-in-noise processed using noise reduction, the latter only when limited to participants with hearing impairment. Neither association was significant when the effects of age were partialled out. Conclusions The findings are consistent with previous research in finding no evidence of a link between sensitivity to TFS and working memory once the effects of age had been partialled out. The results provide some evidence of an influence of signal processing strategy on the association between TFS sensitivity and speech-in-noise recognition. However, further research is necessary to assess the generalisability of the findings before any claims can be made regarding any clinical implications of these findings.
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| 21. |
- Ellis, Rachel, et al.
(författare)
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Temporal fine structure: relations to cognition and aided speech recognition
- 2022
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Ingår i: International Journal of Audiology. - : TAYLOR & FRANCIS LTD. - 1499-2027 .- 1708-8186. ; 61:6, s. 473-481
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to investigate how sensitivity to temporal fine structure (TFS) correlates with cognitive abilities and speech recognition in adult hearing aid users. Design: The cognitive tests included measures of working memory and executive function. Aided speech recognition was assessed using an adaptive sentence-in-noise recognition task, and a matrix sentence test presented in two types of noise, using three signal processing strategies. Study sample: One hundred eighty-nine adults with symmetrical sensorineural hearing loss, and at least one year of hearing aid experience. Results: After partialling out the effects of age, sensitivity to TFS correlated with the measures of executive function, but not with working memory. While TFS correlated with some of the speech recognition tasks, neither signal processing condition, difficulty, or background noise type affected the degree to which TFS correlated with performance. Conclusions: The results provide some evidence of an association between TFS and speech-in-noise recognition. That this association was not significantly affected by signal processing strategy goes against the idea that TFS sensitivity is likely to impact on the success of a particular hearing aid signal processing strategy. The results, together with previous findings, suggest a possible link between sensitivity to TFS and visuospatial processing.
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| 22. |
- Franklin, Paul A., et al.
(författare)
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Aquatic connectivity : challenges and solutions in a changing climate
- 2024
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Ingår i: Journal of Fish Biology. - : John Wiley & Sons. - 0022-1112 .- 1095-8649.
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Forskningsöversikt (refereegranskat)abstract
- The challenge of managing aquatic connectivity in a changing climate is exacerbated in the presence of additional anthropogenic stressors, social factors, and economic drivers. Here we discuss these issues in the context of structural and functional connectivity for aquatic biodiversity, specifically fish, in both the freshwater and marine realms. We posit that adaptive management strategies that consider shifting baselines and the socio-ecological implications of climate change will be required to achieve management objectives. The role of renewable energy expansion, particularly hydropower, is critically examined for its impact on connectivity. We advocate for strategic spatial planning that incorporates nature-positive solutions, ensuring climate mitigation efforts are harmonized with biodiversity conservation. We underscore the urgency of integrating robust scientific modelling with stakeholder values to define clear, adaptive management objectives. Finally, we call for innovative monitoring and predictive decision-making tools to navigate the uncertainties inherent in a changing climate, with the goal of ensuring the resilience and sustainability of aquatic ecosystems.
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| 23. |
- Gwynne, Rachel M, et al.
(författare)
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Cholera toxin induces sustained hyperexcitability in submucosal secretomotor neurons in guinea pig jejunum.
- 2009
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Ingår i: Gastroenterology. - : Elsevier BV. - 1528-0012 .- 0016-5085. ; 136:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Neural mechanisms underlying cholera toxin (CT)-induced intestinal hypersecretion remain unclear. We investigated long-term excitability changes in vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) secretomotor neurons after prolonged luminal exposure to CT. METHODS: Isolated segments of guinea pig jejunum were incubated with saline or CT +/- neurotransmitter antagonist in the lumen; the submucosal plexus was then dissected clear, circumferentially adjacent to intact mucosa. Synaptic inputs and firing properties of S neurons in ganglia next to the mucosa in control saline were studied using intracellular recording. Neurons were processed for VIP and NPY immunoreactivity. RESULTS: Thirty S neurons (20 VIP(+), 7 NPY(+), 3 VIP(-)/NPY(-)) from CT-treated preparations and 27 control S neurons (19 VIP(+), 4 NPY(+), 4 VIP(-)/NPY(-)) in ganglia adjacent to intact mucosa were analyzed. VIP(+) and NPY(+) neurons in CT-treated preparations fired significantly more action potentials and for longer periods during injected depolarizing current pulses (50-350 pA) than control neurons. Addition of tetrodotoxin, hexamethonium, granisetron, or the neurokinin-1 (NK1) antagonist SR140333 during the CT incubation blocked CT-induced effects in both neuron types. The NK3 antagonist SR142801 blocked CT-induced effects in NPY(+) neurons and reduced the number of action potentials in VIP(+) neurons. Synaptic activity was unaffected by CT. CONCLUSIONS: CT induces specific and sustained hyperexcitability of secretomotor neurons in enteric pathways. CT acts in the mucosa. Its effect is neurally mediated and depends on 5-hydroxytryptamine-3, nicotinic, and NK1 receptors. This system represents a unique model to understand the neural mechanisms of action of CT and to identify therapeutic targets.
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| 24. |
- Haycock, Philip C., et al.
(författare)
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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
- 2017
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 3:5, s. 636-651
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
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| 25. |
- Hua, Håkan, et al.
(författare)
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Cognitive skills and the effect of noise on perceived effort in employees with aided hearing impairment and normal hearing
- 2014
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Ingår i: Noise & Health. - Mumbai India : Medknow Publications. - 1463-1741 .- 1998-4030. ; 16:69, s. 79-88
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the following study was to examine the relationship between working memory capacity (WMC), executive functions (EFs) and perceived effort (PE) after completing a work-related task in quiet and in noise in employees with aided hearing impairment (HI) and normal hearing. The study sample consisted of 20 hearing-impaired and 20 normally hearing participants. Measures of hearing ability, WMC and EFs were tested prior to performing a work-related task in quiet and in simulated traffic noise. PE of the work-related task was also measured. Analysis of variance was used to analyze within-and between-group differences in cognitive skills, performance on the work-related task and PE. The presence of noise yielded a significantly higher PE for both groups. However, no significant group differences were observed in WMC, EFs, PE and performance in the work-related task. Interestingly, significant negative correlations were only found between PE in the noise condition and the ability to update information for both groups. In summary, noise generates a significantly higher PE and brings explicit processing capacity into play, irrespective of hearing. This suggest that increased PE involves other factors such as type of task that is to be performed, performance in the cognitive skill required solving the task at hand and whether noise is present. We therefore suggest that special consideration in hearing care should be made to the individual's prerequisites on these factors in the labor market.
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| 26. |
- Håkan, Hua, 1986-, et al.
(författare)
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Speech Recognition and Cognitive Skills in Bimodal Cochlear Implant Users
- 2017
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Ingår i: Journal of Speech, Language and Hearing Research. - : American Speech-Language-Hearing Association. - 1092-4388 .- 1558-9102. ; 60:9, s. 2752-2763
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To examine the relation between speech recognition and cognitive skills in bimodal cochlear implant (CI) and hearing aid users.Method: Seventeen bimodal CI users (28-74 years) were recruited to the study. Speech recognition tests were carried out in quiet and in noise. The cognitive tests employed included the Reading Span Test and the Trail Making Test (Daneman & Carpenter, 1980; Reitan, 1958, 1992), measuring working memory capacity and processing speed and executive functioning, respectively. Data were analyzed using paired-sample t tests, Pearson correlations, and partial correlations controlling for age.Results: The results indicate that performance on some cognitive tests predicts speech recognition and that bimodal listening generates a significant improvement in speech in quiet compared to unilateral CI listening. However, the current results also suggest that bimodal listening requires different cognitive skills than does unimodal CI listening. This is likely to relate to the relative difficulty of having to integrate 2 different signals and then map the integrated signal to representations stored in the long-term memory.Conclusions: Even though participants obtained speech recognition benefit from bimodal listening, the results suggest that processing bimodal stimuli involves different cognitive skills than does unimodal conditions in quiet. Thus, clinically, it is important to consider this when assessing treatment outcomes.
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| 27. |
- Iveson, Timothy J., et al.
(författare)
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3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT) : an international, randomised, phase 3, non-inferiority trial
- 2018
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Ingår i: The Lancet Oncology. - : ELSEVIER SCIENCE INC. - 1470-2045 .- 1474-5488. ; 19:4, s. 562-578
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Tidskriftsartikel (refereegranskat)abstract
- Background: 6 months of oxaliplatin-containing chemotherapy is usually given as adjuvant treatment for stage 3 colorectal cancer. We investigated whether 3 months of oxaliplatin-containing chemotherapy would be non-inferior to the usual 6 months of treatment.Methods: The SCOT study was an international, randomised, phase 3, non-inferiority trial done at 244 centres. Patients aged 18 years or older with high-risk stage II and stage III colorectal cancer underwent central randomisation with minimisation for centre, choice of regimen, sex, disease site, N stage, T stage, and the starting dose of capecitabine. Patients were assigned (1: 1) to receive 3 months or 6 months of adjuvant oxaliplatin-containing chemotherapy. The chemotherapy regimens could consist of CAPOX (capecitabine and oxaliplatin) or FOLFOX (bolus and infused fluorouracil with oxaliplatin). The regimen was selected before randomisation in accordance with choices of the patient and treating physician. The primary study endpoint was disease-free survival and the non-inferiority margin was a hazard ratio of 1.13. The primary analysis was done in the intention-to-treat population and safety was assessed in patients who started study treatment. This trial is registered with ISRCTN, number ISRCTN59757862, and follow-up is continuing.Findings: 6088 patients underwent randomisation between March 27, 2008, and Nov 29, 2013. The intended treatment was FOLFOX in 1981 patients and CAPOX in 4107 patients. 3044 patients were assigned to 3 month group and 3044 were assigned to 6 month group. Nine patients in the 3 month group and 14 patients in the 6 month group did not consent for their data to be used, leaving 3035 patients in the 3 month group and 3030 patients in the 6 month group for the intention-to-treat analyses. At the cutoff date for analysis, there had been 1482 disease-free survival events, with 740 in the 3 month group and 742 in the 6 month group. 3 year disease-free survival was 76.7% (95% CI 75.1-78.2) for the 3 month group and 77.1% (75.6-78.6) for the 6 month group, giving a hazard ratio of 1.006 (0.909-1.114, test for non-inferiority p=0.012), significantly below the non-inferiority margin. Peripheral neuropathy of grade 2 or worse was more common in the 6 month group (237 [58%] of 409 patients for the subset with safety data) than in the 3 month group (103 [25%] of 420) and was long-lasting and associated with worse quality of life. 1098 serious adverse events were reported (492 reports in the 3 month group and 606 reports in the 6 month group) and 32 treatment-related deaths occurred (16 in each group).Interpretation: In the whole study population, 3 months of oxaliplatin-containing adjuvant chemotherapy was non-inferior to 6 months of the same therapy for patients with high-risk stage II and stage III colorectal cancer and was associated with reduced toxicity and improved quality of life. Despite the fact the study was underpowered, these data suggest that a shorter duration leads to similar survival outcomes with better quality of life and thus might represent a new standard of care.
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| 28. |
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| 29. |
- Molander, Peter, et al.
(författare)
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Online administration of a speech in noise test and its relationship to cognition, hearing problems and mental health
- 2015
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Konferensbidrag (refereegranskat)abstract
- Hearing loss is common, but often both undetected and untreated. In this two-part study we evaluated an online hearing test and used this test to explore potential links between hearing status, cognitive abilities, psychological distress as well as quality of life.Out of a total of 1370 online recruited participants who completed the procedure, 16.2% failed the online hearing test. Hearing difficulties were more prevalent among the older participants. Poor self-rated hearing ability, as measured by the Amsterdam Inventory of Auditory Handicap, increased the odds ratio for failing the hearing test (OR 2.34, 95 % CI 1.74-3.15). The same was true for scoring above the cut-off score of 11 on the anxiety subscale on the Hospital Anxiety and Depression Scale (OR 2.55, 95 % CI 1.22-5.33). On the other hand, good performance on the cognitive tasks lowered the risk for a failed hearing test.We conclude that online hearing tests may have the potential to reduce the time lag between noticing hearing difficulties and beginning a process to address the problem. Moreover, online data collection facilitate large scale investigations on the links between hearing, cognition and perceived communication and mental health problems.
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| 30. |
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| 31. |
- Robles-Zurita, Jose, et al.
(författare)
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SCOT : a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer
- 2018
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 119:11, s. 1332-1338
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.METHODS: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Quality-adjusted partitioned survival analysis and Kaplan-Meier Sample Average Estimator estimated QALYs and costs. Probabilistic sensitivity and subgroup analysis was undertaken.RESULTS: The 3M arm is less costly (-4881; pound 95% CI: -6269; pound -3492) pound and entails (non-significant) QALY gains (0.08; 95% CI: -0.086; 0.230) due to a better significant quality of life. The net monetary benefit was significantly higher in 3M under a wide range of monetary values of a QALY. The subgroup analysis found similar results for patients in the CAPOX regimen. However, for the FOLFOX regimen, 3M had lower QALYs than 6M (not statistically significant).CONCLUSIONS: Overall, 3M dominates 6M with no significant detrimental impact on QALYs. The results provide the economic case that a 3M treatment strategy should be considered a new standard of care.
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| 32. |
- Signoret, Carine, et al.
(författare)
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Effects of cognitive ability and top-down support on speech-in-noise perception
- 2013
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Ingår i: Abstract book. ; , s. 191-191
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- As recent results encourage the inclusion of speech in noise (SIN) testing as part of a routine hearing screening test (Arlinger, Lunner, Lyxell, & Pichora-Fuller, 2009), we need to understand exactly which abilities SIN tests are actually indexing. In this study, we investigated the effect of top-down support on speech-in-noi-se perception and the influence of cognitive ability on this relationship by using monosyllabic words presented with stationary background noise in an adaptive threshold procedure. Participants with normal-hearing had to identify (Condition 1) or recognize (Conditions 2 and 3) a target word in noise in descending (Conditions 1 and 3) or ascending (Condition 2) levels of difficulty. Cognitive ability was measured using the reading span and letter memory tests. The results showed a significant effect of top-down support on speech in noise perception thresholds. The magnitude of this effect was predicted by performance on the letter memory test, indicating that good updating ability is, in presence of top-down support, a good predictor of speech in noise perception, in accordance with the Ease of Language Understanding model (Rönnberg, Rudner, Foo, & Lunner, 2008; Rönnberg, 2003; Stenfelt & Rönnberg, 2009). The results of the study highlight the importance of considering that non-auditory factors may play a significant role in speech-in-noise perception. The degree to which non-auditory factors influence speech-in-noise perception is affected by both the test procedure chosen and the cognitive ability of the listener.
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| 33. |
- Socher, Michaela, 1989-, et al.
(författare)
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Comparison of Expressive Spoken Language Skills in Children With Cochlear Implants and Children With Typical Hearing
- 2020
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Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- When children start formal education, they are expected to be able to express complex thoughts. However, in order to do so, they need to be able to use both complex grammatical structures and a variety of words. One group that is at risk of having a delay in terms of their expressive language ability is children with cochlear implants (CI). In this study, we evaluated whether children with CI perform comparably to children with typical hearing (TH) on a standard expressive spoken grammar and a standard expressive spoken vocabulary task when the groups were matched on non-verbal intelligence and working memory capacity. It was found that the children with CI in this study performed more poorly on a standard expressive spoken vocabulary task but not on a standard expressive spoken grammar task when compared to the children with TH. Differences in terms of expressive spoken vocabulary do not seem to be explained by differences in cognitive ability. In addition, the variation in terms of expressive spoken language ability was larger in the children with CI compared to the children with TH. This might be explained by additional confounding factors, like the time of language deprivation or by a greater influence of cognitive differences for the acquisition of spoken language for children with CI.
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| 34. |
- Socher, Michaela, et al.
(författare)
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Pragmatic Language Skills : A Comparison of Children With Cochlear Implants and Children Without Hearing Loss
- 2019
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Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Pragmatic language ability refers to the ability to use language in a social context. It has been found to be correlated with success in general education for deaf and hard of hearing children. It is therefore of great importance to study why deaf and hard of hearing children often perform more poorly than their hearing peers on tests measuring pragmatic language ability. In the current study the Pragmatics Profile questionnaire from the CELF-IV battery was used to measure pragmatic language ability in children using cochlear implants (N = 14) and children without a hearing loss (N = 34). No significant difference was found between the children with cochlear implants (CI) and the children without hearing loss (HL) for the sum score of the pragmatics language measure. However, 35.71% of the children with CI performed below age norm, while only 5.89% of the children without HL performed below age norm. In addition, when dividing the sum score into three sub-measures: Rituals and Conversational skills (RCS), Asking for, Giving, and Responding to Information (AGRI), and Nonverbal Communication skills (NCS), significant differences between the groups were found for the NCS measure and a tendency for a difference was found for the RCS measure. In addition, all three sub-measures (NCS, AGRI, RCS) were correlated to verbal fluency in the children with CI, but not the children without HL.
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| 35. |
- Socher, Michaela, 1989-
(författare)
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Reasons for Language : Language and Analogical Reasoning Ability in Children with Cochlear Implants and Children with Typical Hearing
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The usage-based model of language acquisition assumes that language is learned by its usage. General cognitive processes, especially analogical reasoning ability, are assumed to lead to the understanding of words and grammatical structures. It has been argued that the time of language or auditory deprivation children with cochlear implants (CIs) often experience early in life, might affect both their language and their cognitive abilities. Children with CIs have disadvantages in terms of language acquisition as they start receiving language input later than peers with typical hearing (TH), and the perceptual quality of the input is reduced. However, they might have additional difficulties in language acquisition if their analogical reasoning ability is negatively influenced by the language or auditory deprivation early in life. The results found in this thesis show that the language delays often seen in children with CIs are not explained by differences in analogical reasoning ability. Results indicate that analogical reasoning ability has a limited influence on language acquisition for the tested age-group. However, language abilities affect the performance on analogical reasoning tasks which are either verbal or can be supported by verbal strategies. This needs to be taken into consideration when comparing analogical reasoning ability of children with CI sand children with TH. In addition, the results from this thesis indicate that the structure of the mental lexicon is associated with the communication skills of children with CIs. The structure of the mental lexicon is most likely influenced by the amount of language input a child receives. The main implication of the results is that emphasis should be put on reducing the duration of language deprivation and to improve the quality of the language input for children with CIs.
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| 36. |
- Stenbäck, Victoria, 1985-, et al.
(författare)
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Relationships between behavioural and self-report measures in speech recognition in noise
- 2023
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Ingår i: International Journal of Audiology. - Abingdon, Oxfordshire, United Kingdom : Taylor & Francis. - 1499-2027 .- 1708-8186. ; 62:2, s. 101-109
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveUsing data from the n200-study, we aimed to investigate the relationship between behavioural (the Swedish HINT and Hagerman speech-in-noise tests) and self-report (Speech, Spatial and Qualities of Hearing Questionnaire (SSQ)) measures of listening under adverse conditions.DesignThe Swedish HINT was masked with a speech-shaped noise (SSN), the Hagerman was masked with a SSN and a four-talker babble, and the subscales from the SSQ were used as a self-report measure. The HINT and Hagerman were administered through an experimental hearing aid.Study sampleThis study included 191 hearing aid users with hearing loss (mean PTA4 = 37.6, SD = 10.8) and 195 normally hearing adults (mean PTA4 = 10.0, SD = 6.0).ResultsThe present study found correlations between behavioural measures of speech-in-noise and self-report scores of the SSQ in normally hearing individuals, but not in hearing aid users.ConclusionThe present study may help identify relationships between clinically used behavioural measures, and a self-report measure of speech recognition. The results from the present study suggest that use of a self-report measure as a complement to behavioural speech in noise tests might help to further our understanding of how self-report, and behavioural results can be generalised to everyday functioning.
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