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| 3. |
- Hilbert-Carius, Peter, et al.
(författare)
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Successfully REBOA performance: does medical specialty matter? International data from the ABOTrauma Registry
- 2020
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Ingår i: World Journal of Emergency Surgery. - : Springer Science and Business Media LLC. - 1749-7922. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- © 2020, The Author(s). Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a minimally invasive procedure being increasingly utilized to prevent patients with non-compressible torso hemorrhage from exsanguination. The increased use of REBOA is giving rise to discussion about “Who is and who should be performing it?” Methods: Data from the international ABO (aortic balloon occlusion) Trauma Registry from between November 2014 and April 2020 were analyzed concerning the question: By who, how, and where is REBOA being performed? The registry collects retrospective and prospective data concerning use of REBOA in trauma patients. Results: During the study period, 259 patients had been recorded in the registry, 72.5% (n = 188) were males with a median (range) age of 46 (10-96) years. REBOA was performed in the ER in 50.5%, in the OR in 41.5%, and in the angiography suite in 8% of patients. In 54% of the patients REBOA was performed by surgeons (trauma surgeons 28%, vascular surgeons 22%, general surgeons 4%) and in 46% of the patients by non-surgeons (emergency physicians 31%, radiologists 9.5%, anesthetists 5.5%). Common femoral artery (CFA) access was achieved by use of external anatomic landmarks and palpation alone in 119 patients (51%), by cutdown in 57 patients (24%), using ultrasound in 49 patients (21%), and by fluoroscopy in 9 patients (4%). Significant differences between surgeons and non-surgeons were found regarding patient’s age, injury severity, access methods, place where REBOA was performed, location patients were taken to from the emergency room, and mortality. Conclusion: A substantial number of both surgical and non-surgical medical disciplines are successfully performing REBOA to an almost equal extent. Surgical cutdown is used less frequently as access to the CFA compared with reports in older literature and puncture by use of external anatomic landmarks and palpation alone is used with a high rate of success. Instead of discussing “Who should be performing REBOA?” future research should focus on “Which patient benefits most from REBOA?”
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- Adams, David, et al.
(författare)
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Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy : 12-month results of an open-label extension study
- 2021
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:1, s. 49-59
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Tidskriftsartikel (refereegranskat)abstract
- Background Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Methods This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries as of Sept 24, 2018. Patients were eligible if they had completed the phase 3 APOLLO or phase 2 OLE parent studies and tolerated the study drug. Eligible patients from APOLLO (patisiran and placebo groups) and the phase 2 OLE (patisiran group) studies enrolled in this global OLE trial and received patisiran 0.3 mg/kg by intravenous infusion every 3 weeks with plans to continue to do so for up to 5 years. Efficacy assessments included measures of polyneuropathy (modified Neuropathy Impairment Score +7 [mNIS+7]), quality of life, autonomic symptoms, nutritional status, disability, ambulation status, motor function, and cardiac stress, with analysis by study groups (APOLLO-placebo, APOLLO-patisiran, phase 2 OLE patisiran) based on allocation in the parent trial. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Safety analyses included all patients who received one or more dose of patisiran up to the data cutoff. This study is registered with ClinicalTrials.gov, NCT02510261. Findings Between July 13, 2015, and Aug 21, 2017, of 212 eligible patients, 211 were enrolled: 137 patients from the APOLLO-patisiran group, 49 from the APOLLO-placebo group, and 25 from the phase 2 OLE patisiran group. At the data cutoff on Sept 24, 2018, 126 (92%) of 137 patients from the APOLLO-patisiran group, 38 (78%) of 49 from the APOLLO-placebo group, and 25 (100%) of 25 from the phase 2 OLE patisiran group had completed 12-month assessments. At 12 months, improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in the global OLE (APOLLO-patisiran mean change -4.0, 95 % CI -7.7 to -0.3; phase 2 OLE patisiran -4.7, -11.9 to 2.4). Mean mNIS+7 score improved from global OLE enrolment in the APOLLO-placebo group (mean change from global OLE enrolment -1.4, 95% CI -6.2 to 3.5). Overall, 204 (97%) of 211 patients reported adverse events, 82 (39%) reported serious adverse events, and there were 23 (11%) deaths. Serious adverse events were more frequent in the APOLLO-placebo group (28 [57%] of 49) than in the APOLLO-patisiran (48 [35%] of 137) or phase 2 OLE patisiran (six [24%] of 25) groups. The most common treatment-related adverse event was mild or moderate infusion-related reactions. The frequency of deaths in the global OLE was higher in the APOLLO-placebo group (13 [27%] of 49), who had a higher disease burden than the APOLLO-patisiran (ten [7%] of 137) and phase 2 OLE patisiran (0 of 25) groups. Interpretation In this interim 12-month analysis of the ongoing global OLE study, patisiran appeared to maintain efficacy with an acceptable safety profile in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisiran. Copyright (C) 2020 Elsevier Ltd. All rights reserved.
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| 8. |
- Emre, C, et al.
(författare)
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Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
- 2022
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 245-
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Tidskriftsartikel (refereegranskat)abstract
- Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the AppNL-G-F/NL-G-F mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activation and inflammatory factors. The treatment ameliorated memory deficits accompanied by a restoration of gamma oscillation deficits, together with a dramatic decrease in microglial activation. These findings open potential avenues for therapeutic exploration of pro-resolving LMs in AD, using a non-invasive route.
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| 10. |
- McKeith, IG, et al.
(författare)
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Diagnosis and management of dementia with Lewy bodies - Third report of the DLB consortium
- 2005
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Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 1526-632X .- 0028-3878. ; 65:12, s. 1863-1872
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Forskningsöversikt (refereegranskat)abstract
- The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and Parkinson disease with dementia may be difficult to apply in clinical settings and in such cases the term most appropriate to each individual patient should be used. Generic terms such as Lewy body (LB) disease are often helpful. The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. The new criteria take into account both Lewy-related and Alzheimer disease (AD)-type pathology to allocate a probability that these are associated with the clinical DLB syndrome. Finally, the authors suggest patient management guidelines including the need for accurate diagnosis, a target symptom approach, and use of appropriate outcome measures. There is limited evidence about specific interventions but available data suggest only a partial response of motor symptoms to levodopa: severe sensitivity to typical and atypical antipsychotics in similar to 50%, and improvements in attention, visual hallucinations, and sleep disorders with cholinesterase inhibitors.
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| 11. |
- Qin, Jiufu, 1985, et al.
(författare)
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Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues
- 2021
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Ingår i: Nature Catalysis. - : Springer Science and Business Media LLC. - 2520-1158. ; 4:6, s. 498-509
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Tidskriftsartikel (refereegranskat)abstract
- Structurally complex and diverse polyamines and polyamine analogues are potential therapeutics and agrochemicals that can address grand societal challenges, for example, healthy ageing and sustainable food production. However, their structural complexity and low abundance in nature hampers either bulk chemical synthesis or extraction from natural resources. Here we reprogrammed the metabolism of baker’s yeast Saccharomyces cerevisiae and recruited nature’s diverse reservoir of biochemical tools to enable a complete biosynthesis of multiple polyamines and polyamine analogues. Specifically, we adopted a systematic engineering strategy to enable gram-per-litre-scale titres of spermidine, a central metabolite in polyamine metabolism. To demonstrate the potential of our polyamine platform, various polyamine synthases and ATP-dependent amide-bond-forming systems were introduced for the biosynthesis of natural and unnatural polyamine analogues. The yeast platform serves as a resource to accelerate the discovery and production of polyamines and polyamine analogues, and thereby unlocks this chemical space for further pharmacological and insecticidal studies. [Figure not available: see fulltext.]
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| 27. |
- Emre, C, et al.
(författare)
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Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease
- 2021
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Ingår i: Acta neuropathologica communications. - : Springer Science and Business Media LLC. - 2051-5960. ; 9:1, s. 116-
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Tidskriftsartikel (refereegranskat)abstract
- Sustained brain chronic inflammation in Alzheimer’s disease (AD) includes glial cell activation, an increase in cytokines and chemokines, and lipid mediators (LMs), concomitant with decreased pro-homeostatic mediators. The inflammatory response at the onset of pathology engages activation of pro-resolving, pro-homeostatic LMs followed by a gradual decrease. We used an APP knock-in (App KI) AD mouse that accumulates β-amyloid (Aβ) and presents cognitive deficits (at 2 and 6 months of age, respectively) to investigate LMs, their precursors, biosynthetic enzymes and receptors, glial activation, and inflammatory proteins in the cerebral cortex and hippocampus at 2-, 4-, 8- and 18-month-old in comparison with wild-type (WT) mice. We used LC-mass-spectrometry and MALDI molecular imaging to analyze LMs and phospholipids, and immunochemistry for proteins. Our results revealed an age-specific lipid and cytokine profile, and glial activation in the App KI mice. Despite an early onset of Aβ pathology, pro-inflammatory and pro-resolving LMs were prominently increased only in the oldest age group. Furthermore, the LM biosynthetic enzymes increased, and their receptor expression decreased in the aged App KI mice. Arachidonic acid (AA)-containing phospholipid molecular species were elevated, correlating with decreased cPLA2 activity. MALDI molecular imaging depicted differential distribution of phospholipids according to genotype in hippocampal layers. Brain histology disclosed increased microglia proliferation starting from young age in the App KI mice, while astrocyte numbers were enhanced in older ages. Our results demonstrate that the brain lipidome is modified preferentially during aging as compared to amyloid pathology in the model studied here. However, alterations in phospholipids signal early pathological changes in membrane composition.
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| 32. |
- Firdaus, Yuliar, et al.
(författare)
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Novel wide-bandgap non-fullerene acceptors for efficient tandem organic solar cells
- 2020
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 8:3, s. 1164-1175
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Tidskriftsartikel (refereegranskat)abstract
- The power conversion efficiency (PCE) of tandem organic photovoltaics (OPVs) is currently limited by the lack of suitable wide-bandgap materials for the front-cell. Here, two new acceptor molecules, namely IDTA and IDTTA, with optical bandgaps (Eoptg) of 1.90 and 1.75 eV, respectively, are synthesized and studied for application in OPVs. When PBDB-T is used as the donor polymer, single-junction cells with PCE of 7.4%, for IDTA, and 10.8%, for IDTTA, are demonstrated. The latter value is the highest PCE reported to date for wide-bandgap (Eoptg ≥ 1.7 eV) bulk-heterojunction OPV cells. The higher carrier mobility in IDTTA-based cells leads to improved charge extraction and higher fill-factor than IDTA-based devices. Moreover, IDTTA-based OPVs show significantly improved shelf-lifetime and thermal stability, both critical for any practical applications. With the aid of optical-electrical device modelling, we combined PBDB-T:IDTTA, as the front-cell, with PTB7-Th:IEICO-4F, as the back-cell, to realize tandem OPVs with open circuit voltage of 1.66 V, short circuit current of 13.6 mA cm-2 and a PCE of 15%; in excellent agreement with our theoretical predictions. The work highlights IDTTA as a promising wide-bandgap acceptor for high-performance tandem OPVs. © 2019 The Royal Society of Chemistry.
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| 33. |
- Fortetsanakis, G., et al.
(författare)
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To subscribe, or not to subscribe : Modeling and analysis of service paradigms in cellular markets
- 2012
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Ingår i: 2012 IEEE International Symposium on Dynamic Spectrum Access Networks, DYSPAN 2012. - : IEEE. - 9781467344487 ; , s. 189-200
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Konferensbidrag (refereegranskat)abstract
- Traditionally customers subscribe to specific providers and are served by accessing base stations (BSs) of the network of their provider. Inevitably subscribers with relatively 'high' usage pattern and data-rate requirements are subsidized by the ones with lower usage and data-rates. As the wireless technology advances, a diverse set of services will be available. This paper introduces the 'flex service' paradigm that allows a customer to dynamically access BSs of different providers based on various criteria, such as profile, network conditions, and offered prices. 'Flex users' can select the appropriate provider and BS on a per-session basis. This work considers a diverse customer population with respect to their demand, their preference on data-rate over price, their tolerance on the blocking probabilities of their sessions, and their willingness to pay for certain services. Users can dynamically decide to buy a long-term subscription or become flex users. In this paper, we develop a rich framework for modeling and analysis of such markets in different spatio-temporal scales. We analyze the evolution of markets with the flex service paradigm, focusing on whether it can improve the quality-of-service (QoS), social welfare, flexibility and further enhance the competition among providers. The main contribution of this paper is detailed modeling and indepth performance analysis of such complex markets, in different spatial and temporal scales. It considers the perspective of clients, providers, and regulators. It demonstrates the benefits of markets with the flex service paradigm and compares them with the ones that only offer subscription contracts.
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| 34. |
- Gialeli, Chrysostomi, et al.
(författare)
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Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy
- 2021
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Ingår i: Journal of Experimental and Clinical Cancer Research. - : Springer Science and Business Media LLC. - 1756-9966. ; 40:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highly invasive triple negative breast cancer (TNBC). Methods: We examined the antitumor action of CSMD1 in three TNBC cell lines overexpressing CSMD1, MDA-MB-231, BT-20 and MDA-MB-486, in vitro using scanning electron microscopy, proteome array, qRT-PCR, immunoblotting, proximity ligation assay, ELISA, co-immunoprecipitation, immunofluorescence, tumorsphere formation assays and flow cytometric analysis. The mRNA expression pattern and clinical relevance of CSMD1 were evaluated in 3520 breast cancers from a modern population-based cohort. Results: CSMD1-expressing cells had distinct morphology, with reduced deposition of extracellular matrix components. We found altered expression of several cancer-related molecules, as well as diminished expression of signaling receptors including Epidermal Growth Factor Receptor (EGFR), in CSMD1-expressing cells compared to control cells. A direct interaction of CSMD1 and EGFR was identified, with the EGF-EGFR induced signaling cascade impeded in the presence of CSMD1. Accordingly, we detected increased ubiquitination levels of EGFR upon activation in CSMD1-expressing cells, as well as increased degradation kinetics and chemosensitivity. Accordingly, CSMD1 expression rendered tumorspheres pretreated with gefitinib more sensitive to chemotherapy. In addition, higher mRNA levels of CSMD1 tend to be associated with better outcome of triple negative breast cancer patients treated with chemotherapy. Conclusions: Our results indicate that CSMD1 cross-talks with the EGFR endosomal trafficking cascade in a way that renders highly invasive breast cancer cells sensitive to chemotherapy. Our study unravels one possible underlying molecular mechanism of CSMD1 tumor suppressor function and may provide novel avenues for design of better treatment.
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| 35. |
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| 36. |
- Hageman, Isabel C., et al.
(författare)
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A Quality Assessment of the ARM-Net Registry Design and Data Collection
- 2023
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Ingår i: Journal of Pediatric Surgery. - : Elsevier BV. - 0022-3468. ; 58:10, s. 1921-1928
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Tidskriftsartikel (refereegranskat)abstract
- Background: Registries are important in rare disease research. The Anorectal Malformation Network (ARM-Net) registry is a well-established European patient registry collecting demographic, clinical, and functional outcome data. We assessed the quality of this registry through review of the structure, data elements, collected data, and user experience. Material and methods: Design and data elements were assessed for completeness, consistency, usefulness, accuracy, validity, and comparability. An intra- and inter-user variability study was conducted through monitoring and re-registration of patients. User experience was assessed via a questionnaire on registration, design of registry, and satisfaction. Results: We evaluated 119 data elements, of which 107 were utilized and comprised 42 string and 65 numeric elements. A minority (37.0%) of the 2278 included records had complete data, though this improved to 83.5% when follow-up elements were excluded. Intra-observer variability demonstrated 11.7% incongruence, while inter-observer variability was 14.7%. Users were predominantly pediatric surgeons and typically registered patients within 11–30 min. Users did not experience any significant difficulties with data entry and were generally satisfied with the registry, but preferred more longitudinal data and patient-reported outcomes. Conclusions: The ARM-Net registry presents one of the largest ARM cohorts. Although its collected data are valuable, they are susceptible to error and user variability. Continuous evaluations are required to maintain relevant and high-quality data and to achieve long-term sustainability. With the recommendations resulting from this study, we call for rare disease patient registries to take example and aim to continuously improve their data quality to enhance the small, but impactful, field of rare disease research. Level of Evidence: V.
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| 37. |
- Herman, Zachary J, et al.
(författare)
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Outcomes of bone-patellar tendon-bone autograft and quadriceps tendon autograft for ACL reconstruction in an all-female soccer player cohort with mean 4.8-year follow up.
- 2024
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Ingår i: Journal of ISAKOS : joint disorders & orthopaedic sports medicine. - 2059-7762. ; 9:1, s. 34-38
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Tidskriftsartikel (refereegranskat)abstract
- The purpose is to compare functional outcomes, return to soccer rates, and revision rates in an all-female soccer player cohort undergoing quadriceps tendon (QT) autograft ACLR versus bone-patellar tendon-bone (BPTB) autograft ACLR.Female soccer players who sustained an ACL rupture and underwent primary anatomic, single-bundle ACLR with BPTB autograft or QT autograft were included. Demographic and surgical characteristics were collected. Outcomes of interest included Tegner score, International Knee Documentation Committee (IKDC) score, Marx score, return to soccer rates, and failure rates.Data on 23 patients undergoing BPTB autograft ACLR and 14 undergoing QT autograft ACLR was available. Average age was 18.7 years, and average follow up was 4.8 years. Overall, 76% (28/37) returned to soccer and 5.4% (2/37) underwent revision ACLR. No major significant differences were found in demographic or surgical characteristics. No differences were found in postoperative IKDC scores, preoperative, postoperative, or change from pre-to postoperative Marx activity scores, or pre-and postoperative Tegner scores between the groups. QT autograft ACLR patients had significantly less change in Tegner scores pre-to postoperatively compared to the BTPB autograft ACLR group (0.6±1.2 versus 2.1±1.8; p=0.02). Both groups had similar rates of return to soccer [78% (18/23) BPTB autograft ACLR versus 71% (10/14) QT autograft ACLR; p=0.64] and rates of revision (8.7 % (2/23) BPTB autograft ACLR; 0 % (0/14) QT autograft ACLR.Results of this study suggest that BPTB autograft ACLR and QT autograft ACLR produce comparable, successful functional and return to soccer outcomes in this all-female soccer player cohort study. Larger, prospective studies are needed to improve the strength of conclusions and provide more information on the optimal graft choice for female soccer players. Surgeons can use the results of this study to counsel female soccer players on expected outcomes after ACLR.III.
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| 40. |
- Stahl, Günter K., et al.
(författare)
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Sociocultural integration in mergers and acquisitions: Unresolved paradoxes and directions for future research
- 2013
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Ingår i: Thunderbird International Business Review. - : Wiley. - 1096-4762 .- 1520-6874. ; 55:4, s. 333-356
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Tidskriftsartikel (refereegranskat)abstract
- Despite decades of research, the key factors for success in mergers and acquisitions (M&As) and the reasons why M&As often fail remain poorly understood. While attempts to explain M&A success and failure have traditionally focused on strategic and financial factors, an emergent field of inquiry has been directed at the sociocultural and human resources issues involved in the integration of acquired or merging firms. This research has sought to explain M&A performance and underperformance in terms of the impact that variables such as cultural fit, management style similarity, the pattern of dominance between merging firms, the acquirer's degree of cultural tolerance, and the social climate surrounding a takeover have on the postmerger integration process. In this article, we attempt to take stock of, and synthesize, the findings from research on sociocultural and human resources integration in M&A, to identify conflicting perspectives and unresolved questions as well as several underresearched areas, and then use our analyses to propose an agenda for the next stage of research in this field. © 2013 Wiley Periodicals, Inc.
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| 41. |
- Tuysuz, Emre Can, et al.
(författare)
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Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
- 2024
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Ingår i: Journal of Experimental and Clinical Cancer Research. - 1756-9966. ; 43, s. 1-16
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the brain, its function in gliomas, malignant brain tumors originating from glial cells, has not been investigated.METHODS: Three cohorts of glioma patients comprising 1500 patients were analyzed in our study along with their clinical data. H4, U-118 and U-87 cell lines were used to investigate the tumor suppressor function of CSMD1 in gliomas. PDGFB-induced brain tumor model was utilized for the validation of in vitro data.RESULTS: The downregulation of CSMD1 expression correlated with reduced overall and disease-free survival, elevated tumor grade, wild-type IDH genotype, and intact 1p/19q status. Moreover, enhanced activity was noted in the neuroinflammation pathway. Importantly, ectopic expression of CSMD1 in glioma cell lines led to decreased aggressiveness in vitro. Mechanically, CSMD1 obstructed the TNF-induced NF-kB and STAT3 signaling pathways, effectively suppressing the secretion of IL-6 and IL-8. There was also reduced survival in PDGFB-induced brain tumors in mice when Csmd1 was downregulated.CONCLUSIONS: Our study has identified CSMD1 as a tumor suppressor in gliomas and elucidated its role in TNF-induced neuroinflammation, contributing to a deeper understanding of glioma pathogenesis.
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| 42. |
- Yavuz, Emre A., et al.
(författare)
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A practical method for estimating performance metrics of call admission control schemes in wireless mobile networks
- 2005
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Ingår i: 2005 IEEE Wireless Communications and Networking Conference, Vols 1-4. - 0780389662 ; , s. 1254-1259
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Konferensbidrag (refereegranskat)abstract
- Providing the desired call blocking probability to not only new but also existing calls has been a challenge for wireless mobile network service providers. To satisfy different requirements for new and handoff call blocking probabilities, several call admission control (CAC) schemes have been proposed in the literature. Exact analysis of these schemes using two dimensional Markov chain is computationally intensive. Therefore under specific assumptions computationally efficient methods to analyze these systems using one dimensional Markov chain models have been considered. The "traditional" approach assumes that channel holding time for new and handoff calls have equal mean values. While the "normalized" approach relaxes this assumption, it is accurate only for the new call bounding CAC scheme. In this paper, we reevaluate the analytical methods for computing call blocking probabilities for several widely known call admission control schemes under more general assumptions by providing an easy to implement method. The numerical results show that when the average values of channel holding times for new and handoff calls are different, the proposed approach gives more accurate results when compared with the traditional and normalized methods based on one dimensional Markov chain modeling, while keeping the computational complexity low.
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| 43. |
- Yavuz, Emre A., et al.
(författare)
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Computationally efficient method to evaluate the performance of guard-channel-based call admission control in cellular networks
- 2006
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Ingår i: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; 55:4, s. 1412-1424
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Tidskriftsartikel (refereegranskat)abstract
- Many guard-channel-based call admission control (CAC) schemes for cellular networks have been proposed to provide the desired quality of service to not only new calls but also ongoing calls when they hand off to neighboring cells. Blocking/dropping probabilities of new/handoff calls are generally analyzed using one-dimensional Markov chain modeling under specific assumptions to avoid solving large sets of flow equations that makes exact analyses of these schemes using multidimensional Markov chain models infeasible. This is the case with the "traditional" approach, which assumes that channel holding times for new and handoff calls have equal mean values, and the "normalized" approach, which relaxes this assumption but is accurate only for the new call bounding CAC scheme. In this paper, we reevaluate the analytical methods for computing new/handoff call blocking/dropping probabilities for several widely known CAC schemes and develop an easy-to-implement method under more general assumptions. Numerical results show that when the mean channel holding times for new and handoff calls are different, the proposed "effective holding time" approach gives more accurate results compared with the traditional and the normalized methods while keeping the computational complexity low. The accuracy of these methods and their levels of computational complexity with the exact solution are also compared.
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| 44. |
- Yavuz, Emre A., et al.
(författare)
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Efficient approximations for call admission control performance evaluations in multi-service networks
- 2006
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Ingår i: GLOBECOM 2006. - 9781424403561
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Konferensbidrag (refereegranskat)abstract
- Several dynamic call admission control (CAC) schemes for cellular networks have been proposed in the literature to reserve resources adaptively to provide the desired quality of service (QoS) to not only high priority calls but also to low priority ones. Efficient adaptive reservations depend on reliable and up-to-date system status feedback provided to the CAC mechanism. However exact analysis of these schemes using multidimensional Markov chain models are intractable in real time due to the need to solve large sets of flow equations. Hence performance metrics such as call blocking probabilities of various QoS classes are generally evaluated using one dimensional Markov chain models assuming that channel occupancy times for all QoS classes have equal mean values and all arriving calls have equal capacity requirements. In this paper we re-evaluate the analytical methods to compute call blocking probabilities of various QoS classes for several widely known CAC schemes by relaxing these assumptions, and propose a novel approximation method for performance evaluation with low computational complexity. Numerical results show that proposed method provides results that match well with the exact solutions.
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| 45. |
- Yavuz, Emre A., et al.
(författare)
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Efficient Methods for Performance Evaluations of Call Admission Control Schemes in Multi-Service Cellular Networks
- 2008
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Ingår i: IEEE Transactions on Wireless Communications. - 1536-1276 .- 1558-2248. ; 7:9, s. 3468-3476
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Tidskriftsartikel (refereegranskat)abstract
- Many dynamic call admission control (CAC) schemes have been proposed in the literature for adaptive reservations in cellular networks. Efficient application of these schemes requires reliable and up-to-date feedback of system performance to the CAC mechanism. However, exact analyses of these schemes in real time using multi-dimensional Markov chain models are challenging due to the need to solve large sets of flow equations. One dimensional Markov chain models have been widely used to derive performance metrics such as call blocking probabilities of multiple traffic classes assuming that all classes of calls have equal capacity requirements and exponentially distributed channel holding times with equal mean values. These assumptions need to be relaxed for a more general evaluation of CAC performance in multi-service cellular networks. In this paper we classify CAC schemes according to their Markov chain models into two categories: symmetric and asymmetric, and develop computationally efficient analytical methods to compute call blocking probabilities of various traffic classes for several widely known CAC schemes under relaxed assumptions. We obtain a product form solution to evaluate symmetric schemes and propose a novel performance evaluation approximation method with low computational cost for asymmetric schemes. Numerical results demonstrate the accuracy and efficiency of the proposed method.
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| 46. |
- Yavuz, Emre A., et al.
(författare)
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Modelling channel occupancy times for voice traffic in cellular networks
- 2007
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Ingår i: 2007 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS, VOLS 1-14. - 9781424403523 ; , s. 332-337
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Konferensbidrag (refereegranskat)abstract
- Call holding times in telephony networks are commonly approximated by exponential distributions to facilitate traffic engineering. However, for traffic engineering of cellular networks, channel occupancy times need to be modeled instead to facilitate analytical modeling or to feed network simulations. In this paper, we classify channel occupancy times and present an empirical study based on data obtained from a real cellular network to determine which probability distribution functions can approximate them better. The results are environment dependent, but no assumptions that can be influential are made, as opposed to previous analytical and simulation studies which results are highly dependent on the assumptions made by the authors. We show that all types of channel occupancy times can be approximated by lognormal distribution. For stationary users, channel occupancy times are commonly approximated by exponential distribution due to its tractability, assuming that cell residence times are also exponentially distributed. However, we show that lognormal distribution fits much better to both channel occupancy and call holding times regardless of whether users are stationary or mobile.
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| 47. |
- Zsidai, Balint, 1993, et al.
(författare)
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Slope-Reducing High Tibial Osteotomy and Over-The-Top Anterior Cruciate Ligament Reconstruction With Achilles Tendon Allograft in Multiple Failed Anterior Cruciate Ligament Reconstruction
- 2022
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Ingår i: Arthroscopy Techniques. - : Elsevier BV. - 2212-6287. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- Graft failure is a challenging complication following anterior cruciate ligament reconstruction (ACL-R). Among the multiple anatomic and nonanatomic risk factors contributing to ACL-R failure, there is accumulating evidence that a posterior tibial slope of 12° or greater may predispose patients to graft failure of primary and revision ACL-R. In addition, previously malpositioned or widened tunnels, as well as limited autograft options, pose challenges in the setting of revision ACL-R. This Technical Note describes a technique to correct an increased posterior tibial slope using slope-reducing high tibial osteotomy, and single stage revision ACL-R with Achilles tendon allograft using the over-the-top route, in a single-stage procedure. The surgical technique involves an anterior approach to the proximal tibia, followed by tibial tubercle osteotomy and anterior closing-wedge osteotomy. The posterior cortical osteotomy hinge is left intact below the insertion of the posterior cruciate ligament. Over-the-top revision ACL-R is then performed using an Achilles tendon allograft passed around the posterior aspect of the lateral femoral condyle and fixed onto the lateral femur.
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