| 1. |
- Balldin, Jan, 1935, et al.
(author)
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Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects
- 2006
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In: Journal of Neural Transmission. ; 113, s. 1511-1517
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Journal article (peer-reviewed)abstract
- Data has accumulated indicating an inverse relation between central serotonergic (5-HT) neurotransmission and blood pressure in hypertensive rats and in healthy individuals. The present study aimed to elucidate whether an inverse relation exists between systolic (SBP) and diastolic (DBP) blood pressure levels and central 5-HT neurotransmission also in a group of alcohol-dependent individuals. Central 5-HT neurotransmission was assessed by using the maximum prolactin (PRL) responses to the 5-HT probe DL-fenfluramine (DL-FEN; 60 mg po.) in 17 alcohol-dependent male subjects investigated during a period of on-going alcohol intake. BP was measured immediately before all time points for blood sampling, and readings before DL-FEN administration were used as the subjects resting BP. Results showed that there were inverse correlations between the maximum PRL responses to DL-FEN and the SBP levels (r = -0.57, p < 0.002) and with the DBP levels (r = -0.52, p < 0.05), respectively. The present study suggests the existence of an association between central 5-HT neurotransmission and blood pressure regulation also in alcohol-dependent individuals.
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| 2. |
- Dimov, Stefan S., et al.
(author)
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4M Network of Excellence : Progress Report 2004-2006
- 2007
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In: 4M 2007. - Dunbeath : Whittles Publishing. - 9781904445531 - 9781420070040 ; , s. xvii-xxxi
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Conference paper (peer-reviewed)abstract
- The 4M Network of Excellence started on 1st October 2004. It is a consortium of 30 academic and research organisations that came together to form the network under the European Commission's 6th Framework Research Programme. The Network has developed a knowledge community in Micro- and Nano- Technology (MNT) for the batch-manufacture of microcomponents and devices in a variety of materials for future microsystems products, particularly in non-silicon materials. This paper gives an overview of the structure, operation and activity of the network since its inception, illustrating the network's progress towards its goals.
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| 3. |
- Dimov, Stefan S., et al.
(author)
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4M Network of Excellence, Progress Report 2006-2008
- 2008
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In: 4M 2008. - Dunbeath : Whittles Publishing. - 9781904445760 ; , s. xv-xxxi
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Conference paper (peer-reviewed)abstract
- This report follows on from last year's "Progress Report 2004-2006" and gives an update on the continuing activities, such as the 4M Network cross-divisional projects and annual conference, as well as a description of the new activities in its third and forth year, such as the first 4M Summer School and Book Series. Finally, as the end of the funded lifetime of the network approaches the steps being taken to set up a 4M Association, which aims to create the organizational infrastructure to support the 4M Knowledge Community established in the last five years, are described.
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| 4. |
- Dimov, Stefan S., et al.
(author)
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4M Network of Excellence, Progress report 2009
- 2009
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In: 4M/ICOMM 2009. ; , s. s.1-9
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Conference paper (peer-reviewed)abstract
- This paper gives a brief overview of the activities of the 4M Network of Excellence during the last nine months of its funded period. The 4M Divisions summarise their activity and outline their plans to continue to working together in future. Finally a summary of achievements during the whole lifetime of the Network is given
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| 5. |
- Engel, C., et al.
(author)
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Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
- 2010
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 19:11, s. 2859-2868
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Journal article (peer-reviewed)abstract
- Background: The genes caspase-8 (CASP8) and caspase-10 (CASP10) functionally cooperate and play a key role in the initiation of apoptosis. Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer. Previous case-control studies have indicated that the polymorphisms CASP8 D302H and CASP10 V410I are associated with a reduced risk of breast cancer in the general population.Methods: To evaluate whether the CASP8 D302H (CASP10 V410I) polymorphisms modify breast or ovarian cancer risk in BRCA1 and BRCA2 mutation carriers, we analyzed 7,353 (7,227) subjects of white European origin provided by 19 (18) study groups that participate in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A weighted cohort approach was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; Ptrend = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; Ptrend = 0.004) for BRCA1 but not for BRCA2 mutation carriers. The CASP10 V410I polymorphism was not associated with breast or ovarian cancer risk for BRCA1 or BRCA2 mutation carriers.Conclusions: CASP8 D302H decreases breast and ovarian cancer risk for BRCA1 mutation carriers but not for BRCA2 mutation carriers.Impact: The combined application of these and other recently identified genetic riskmodifiers could in the future allow better individual risk calculation and could aid in the individualized counseling and decision making with respect to preventive options in BRCA1 mutation carriers.
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| 6. |
- Eriksson, Matts, 1960, et al.
(author)
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Platelet monoamine oxidase B (MAO-B) activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men
- 2006
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In: Journal of Neural Transmission. ; 113, s. 33-41
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Journal article (peer-reviewed)abstract
- Several techniques are used to assess central serotonergic neurotransmission in man, e.g. challenge tests (hormonal and physiological responses to serotonin active drugs), platelet MAO-B activity as well as brain imaging techniques. Little is known about how these tests relate to each other. The aim of the present study was therefore to investigate if platelet MAO-B activity could be related to hormonal and temperature responses to the serotonin active drug DL-fenfluramine in healthy men. Twelve male subjects without any history of psychiatric disorders or drug abuse/dependencies were recruited. Prior to the challenge with 60 mg DL-fenfluramine, which was given orally, blood for determination of platelet MAO-B activity was drawn. Blood samples for determination of serum prolactin and serum cortisol were drawn at baseline and thereafter every hour for the following six hours. In addition, body temperature was measured at the same time-points. ∆-values were calculated as the difference between the baseline values and the highest (prolactin and cortisol) or lowest value (temperature) thereafter. There was a strong positive correlation (r = 0.75, p < 0.02) between platelet MAO-B activity and ∆-prolactin. No correlations were found to ∆-cortisol, ∆-temperature or any of the baseline values. The results support the notion that the peripheral marker platelet MAO-B activity is related to the function of the central serotonergic neurotransmitter system as assessed by the prolactin response to 60 mg DL-fenfluramin.
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| 7. |
- Fahlke, Claudia, 1964, et al.
(author)
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Neuroendocrine Assessment of Serotonergic, Dopaminergic, and Noradrenergic Functions in Alcohol-Dependent Individuals.
- 2012
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In: Alcoholism, clinical and experimental research. - : Wiley. - 1530-0277 .- 0145-6008. ; 36:1, s. 97-103
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Journal article (peer-reviewed)abstract
- Background: Alcohol dependence has been associated with reduced function of serotonin, dopamine as well as noradrenaline activities in several neuroendocrine studies. To our knowledge, there is, however, no study investigating all these 3 systems with the use of neuroendocrine methods in one and the same alcohol-dependent individual. Methods: Alcohol-dependent individuals (n=42) and controls (n=28) participated in the neuroendocrine test series. Central serotonergic neurotransmission was assessed by the prolactin (PRL) response to citalopram (CIT). The postsynaptic DRD2 function was measured by the growth hormone (GH) response to apomorphine (APO) and the postsynaptic α2-adrenoceptor function by GH response to clonidine (CLON). Results: In the alcohol-dependent individuals, the PRL concentrations were significantly lower at the time points 240minutes and 300minutes after CIT administration and mean delta PRL value was significantly reduced by 45% in comparison with controls. There were no significant differences in APO-GH and CLON-GH concentrations at any time points or in mean delta GH values between the groups. An impaired monoaminergic profile, including all 3 systems, was significantly more frequent in alcohol-dependent individuals than controls (43% vs. 6% respectively). Conclusions: The monoaminergic dysfunction was restricted to an impairment of the serotonergic system, suggesting that this system is especially vulnerable to long-term and excessive alcohol consumption. Moreover, impaired monoaminergic profiles, including low responses in 2 or 3 systems, were more frequently observed in alcohol-dependent individuals than in controls. Such impaired profiles may be of clinical importance, but further studies are needed.
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| 8. |
- Gelot, Linnéa, Docent, 1978-, et al.
(author)
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Navigating APSA Research from a Global Studies Perspective : Chapter 12
- 2021
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In: Researching the Inner Life of the African Peace and Security Architecture. - Leiden : Brill Academic Publishers. - 9789004466777 - 9789004467316 ; , s. 247-268
-
Book chapter (peer-reviewed)abstract
- This chapter sketches a possible way of integrating different approaches to the study of APSA into one field of enquiry, namely global studies. This offers a meaningful heuristic, both in terms of epistemology and methodological implications. First, the chapter appraises of the conceptual contributions that the authors of this edited collection have developed. For analytical reasons, this is organised along a focus on actors, practices, and narratives. Second, the chapter discusses how a specific version of global studies – developed since the beginning of this century mainly in the field of academic teaching – values and draws together the plurality of these proposals. Third, the chapter recapitulates the innovative methods for the study of APSA, introduced in the chapters of this edited volume. Finally, it proposes four overarching methodological considerations that are central to the field of global studies: comparison, historicity, reflexivity, and engagement.
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| 9. |
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| 10. |
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| 11. |
- Landgren, Sara, 1980, et al.
(author)
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Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study.
- 2011
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In: Neuropsychobiology. - : S. Karger AG. - 1423-0224 .- 0302-282X. ; 64:1, s. 38-46
-
Journal article (peer-reviewed)abstract
- Components of the brain reward system, i.e. the mesolimbic dopamine, laterodorsal cholinergic and ghrelin signaling systems, have been implicated in alcohol reward in preclinical studies. Genetic variants of these systems have previously been linked to alcohol dependence. Here, we genotyped 31 single nucleotide polymorphisms (SNPs): 1 SNP in the dopamine D(2) receptor (DRD2) gene, 20 SNPs in 5 different nicotinic acetylcholine receptor subunit (CHRN*) genes, and 10 SNPs in the genes encoding pro-ghrelin (GHRL) and its receptor (GHSR), in a pilot study of type 1 alcoholics (n = 84) and healthy controls (n = 32). These individuals were characterized using the Temperament and Character Inventory. None of the SNPs were associated with risk of alcohol dependence in this population. The GG genotype of SNP rs13261190 in the CHRNB3 was associated with increased novelty seeking, while SNPs of the ghrelin signaling system were associated with decreased self-directedness (AA of rs495225, GHSR) and alterations in self-transcendence (AA of both rs42451 and rs35680, GHRL). In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples.
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| 12. |
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| 13. |
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Recherches sur la vie intérieure de l’Architecture Africaine de Paix et de Sécurité (APSA)
- 2023
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Editorial collection (peer-reviewed)abstract
- Ce volume édité offre des nouvelles perspectives sur la vie intérieure de l'Architecture africaine de paix et de sécurité (APSA) et présente aux spécialistes dand la domaine paix et securité africaine des approches épistémologiques, conceptuelles et méthodologiques innovantes. Basé sur une ouverture intellectuelle et un intérêt pour les perspectives transdisciplinaires, le volume remet en question les courants dominants, nous invitant à réfléchir sur les pratiques de recherche elles-mêmes. S'appuyant sur les perspectives des études globales et des études critiques internationales, les auteurs suivent des approches inductives et laissent les données empiriques enrichir leurs cadres théoriques et leurs outils conceptuels. Dans cette entreprise, ils se concentrent sur les acteurs, les pratiques et les discours impliqués qui donne forme aux institutions regionales. Les analyses ici-présentes examine les hypothèses qui informent habituellement les études sur le régionalisme et la gouvernance en Afrique.
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| 14. |
-
Researching the Inner Life of the African Peace and Security Architecture : APSA inside-out
- 2021
-
Editorial collection (peer-reviewed)abstract
- This edited volume offers new insights into the inner life of the African Peace and Security Architecture (APSA) and introduces scholars of African security dynamics to innovative epistemological, conceptual and methodological approaches. Based on intellectual openness and an interest in transdisciplinary perspectives, the volume challenges existing orthodoxies, poses new questions and opens a discussion on actual research practice. Drawing on Global Studies and critical International Studies perspectives, the authors follow inductive approaches and let the empirical data enrich their theoretical frameworks and conceptual tools. In this endeavor they focus on actors, practices and narratives involved in African Peace and Security and move beyond the often Western-centric premises of research carried out within rigid disciplinary boundaries.Contributors are Michael Aeby, Yvonne Akpasom, Katharina P.W. Döring, Ulf Engel, Fana Gebresenbet Erda, Linnéa Gelot, Amandine Gnanguênon, Toni Haastrup, Jens Herpolsheimer, Alin Hilowle, Jamie Pring, Lilian Seffer, Thomas Kwasi Tieku, Antonia Witt, Dawit Yohannes Wondemagegnehu
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| 15. |
- Walker, Logan C, et al.
(author)
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Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers.
- 2010
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In: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-542X .- 1465-5411. ; 12:6
-
Journal article (peer-reviewed)abstract
- Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies.
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