| 1. |
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| 2. |
- Murari, A., et al.
(författare)
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A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors
- 2024
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Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
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| 3. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 4. |
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| 5. |
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| 6. |
- Boström, Martina, et al.
(författare)
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A role for endothelial cells in radiation-induced inflammation
- 2018
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 94:3, s. 259-271
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To unravel the role of the vasculature in radiation-induced brain tissue damage.Materials and methods: Postnatal day 14 mice received a single dose of 10Gy cranial irradiation and were sacrificed 6h, 24h or 7 days post-irradiation. Endothelial cells were isolated from the hippocampus and cerebellum using fluorescence-activated cell sorting, followed by cell cycle analysis and gene expression profiling.Results: Flow cytometric analysis revealed that irradiation increased the percentage of endothelial cells, relative to the whole cell population in both the hippocampus and the cerebellum. This change in cell distribution indicates that other cell types are more susceptible to irradiation-induced cell death, compared to endothelial cells. This was supported by data showing that genes involved in endothelial cell-specific apoptosis (e.g. Smpd1) were not induced at any time point investigated but that genes involved in cell-cycle arrest (e.g. Cdkn1a) were upregulated at all investigated time points, indicating endothelial cell repair. Inflammation-related genes, on the other hand, were strongly induced, such as Ccl2, Ccl11 and Il6.Conclusions: We conclude that endothelial cells are relatively resistant to ionizing radiation but that they play an active, hitherto unknown, role in the inflammatory response after irradiation. In the current study, this was shown in both the hippocampus, where neurogenesis and extensive cell death after irradiation occurs, and in the cerebellum, where neurogenesis no longer occurs at this developmental age.
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| 7. |
- Meyer, E., et al.
(författare)
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The state of the art in beyond 5G distributed massive multiple-input multiple-output communication system solutions
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Forskningsöversikt (refereegranskat)abstract
- Beyond fifth generation (5G) communication systems aim towards data rates in the tera bits per second range, with improved and flexible coverage options, introducing many new technological challenges in the fields of network architecture, signal pro- cessing, and radio frequency front-ends. One option is to move towards cell-free, or distributed massive Multiple-Input Multiple-Output (MIMO) network architectures and highly integrated front-end solutions. This paper presents an outlook on be- yond 5G distributed massive MIMO communication systems, the signal processing, characterisation and simulation challenges, and an overview of the state of the art in millimetre wave antennas and electronics.
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| 8. |
- Naylor, Andrew Stuart, 1977, et al.
(författare)
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Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain.
- 2008
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 105:38, s. 14632-7
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Tidskriftsartikel (refereegranskat)abstract
- Cranial radiation therapy is commonly used in the treatment of childhood cancers. It is associated with cognitive impairments tentatively linked to the hippocampus, a neurogenic region of the brain important in memory function and learning. Hippocampal neurogenesis is positively regulated by voluntary exercise, which is also known to improve hippocampal-dependent cognitive functions. In this work, we irradiated the brains of C57/BL6 mice on postnatal day 9 and evaluated both the acute effects of irradiation and the effects of voluntary running on hippocampal neurogenesis and behavior 3 months after irradiation. Voluntary running significantly restored precursor cell and neurogenesis levels after a clinically relevant, moderate dose of irradiation. We also found that irradiation perturbed the structural integration of immature neurons in the hippocampus and that this was reversed by voluntary exercise. Furthermore, irradiation-induced behavior alterations observed in the open-field test were ameliorated. Together, these results clearly demonstrate the usefulness of physical exercise for functional and structural recovery from radiation-induced injury to the juvenile brain, and they suggest that exercise should be evaluated in rehabilitation therapy of childhood cancer survivors.
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| 9. |
- Zhu, Changlian, 1964, et al.
(författare)
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X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants.
- 2007
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Ingår i: The European journal of neuroscience. - : Wiley. - 1460-9568 .- 0953-816X. ; 26:12, s. 3402-10
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate that X chromosome-linked inhibitor of apoptosis protein (XIAP) counteracts oxidative stress in two essentially different disease-related models of brain injury, hypoxia-ischemia and irradiation, as judged by lower expression of nitrotyrosine (5-fold) and 4-hydroxy-2-nonenal (10-fold) in XIAP-overexpressing compared with wild-type mice. XIAP overexpression induced up-regulation of at least three antioxidants residing in mitochondria, superoxide dismutase 2, thioredoxin 2 and lysine oxoglutarate reductase. Cytochrome c release from mitochondria was reduced in XIAP-overexpressing mice. Hence, in addition to blocking caspases, XIAP can regulate reactive oxygen species in the brain, at least partly through up-regulation of mitochondrial antioxidants. XIAP-induced prevention of oxidative stress was not secondary to tissue protection because although XIAP overexpression provides tissue protection after hypoxia-ischemia, it does not prevent tissue loss after irradiation. This is a previously unknown role of XIAP and may provide the basis for development of novel protective strategies for both acute and chronic neurodegenerative diseases, where oxidative stress is an integral component of the injury mechanisms involved.
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| 10. |
- Barlind, Anna, 1978, et al.
(författare)
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Decreased cytogenesis in the granule cell layer of the hippocampus and impaired place learning after irradiation of the young mouse brain evaluated using the IntelliCage platform.
- 2010
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Ingår i: Experimental brain research. - : Springer Science and Business Media LLC. - 1432-1106 .- 0014-4819. ; 201:4, s. 781-787
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Tidskriftsartikel (refereegranskat)abstract
- Radiation therapy is used to treat malignant tumors in the brain and central nervous system involvement of leukemia and lymphomas in children. However, ionizing radiation causes a number of adverse long-term side effects in the brain, including cognitive impairment. Hippocampal neurogenesis is important for place learning and has been shown to be decreased by irradiation (IR) in rats and mice. In the present study, 10-day-old male mice received 6-Gy IR to the brain on postnatal day 10. We used BrdU labeling of the granule cell layer (GCL) of the hippocampus to evaluate cell proliferation and survival. An unbiased, automated platform for monitoring of behavior in a group housing environment (IntelliCage) was used to evaluate place learning 2 months after IR. We show that cranial IR impaired place learning and reduced BrdU labeling by 50% in the GCL. Cranial IR also reduced whole body weight gain 5%. We conclude that this experimental paradigm provides a novel and time-saving model to detect differences in place learning in mice subjected to IR. This method of detecting behavioral differences can be used for further studies of adverse effects of IR on hippocampal neurogenesis and possible new strategies to ameliorate the negative effects of IR on cognition.
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| 11. |
- Barlind, Anna, 1978, et al.
(författare)
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The growth hormone secretagogue hexarelin increases cell proliferation in neurogenic regions of the mouse hippocampus.
- 2010
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Ingår i: Growth hormone & IGF research. - : Elsevier BV. - 1532-2238 .- 1096-6374. ; 20:1, s. 49-54
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Radiation therapy (RT) to the brain is often used in the treatment of children with different types of malignant diseases affecting the brain. However, RT in childhood may also have severe side effects including impaired brain maturation and intellectual development. For childhood cancer survivors these adverse effects of RT can cause lifelong disability and suffering. Therefore, there is an unmet need to limit late effects after RT. Precursor cells in the subgranular zone of the dentate gyrus (DG) in the hippocampus are particularly sensitive to irradiation (IR). This may be of significance as newly generated neurons in the DG are important for memory and learning. GH secretagogues (GHS) have previously been shown to promote neurogenesis and to have neuroprotective effects. In addition, several parts of the brain, including the hippocampus, have been shown to express the GHS receptor 1a (GHS-R1a). The aim of this study was to evaluate the potential effect of the GHS hexarelin on proliferation and survival of progenitor cells in the hippocampus after brain IR in a mouse model. DESIGN: In the present study, 10-day-old male mice received 6Gy cranial IR. Non-irradiated sham animals were used as controls. We treated one group of irradiated and one sham group with hexarelin (100mug/kg/day) for 28days and used immunohistochemical labeling of bromo-deoxy uridine (BrdU) and phospho-histone H3 of the granular cell layer of the DG to evaluate proliferation and cell survival after IR at postnatal day ten. RESULTS: Our results show that hexarelin significantly increased the number of BrdU-positive cells in the granule cell layer by approximately 50% compared to controls. CONCLUSION: The increased number of BrdU-positive cells in the granule cell layer suggests a partial restoration in the pool of proliferating cells by hexarelin after IR.
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| 12. |
- Bejhed Stjernberg, Rebecca, et al.
(författare)
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Magnetophoretic Transport Line System for Rapid On-Chip Attomole Protein Detection
- 2015
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 31:37, s. 10296-10302
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Tidskriftsartikel (refereegranskat)abstract
- A lab-on-a-chip traveling wave magnetophoresis approach for sensitive and rapid protein detection is reported. In this method, a chip-based magnetic microarray comprising lines of micrometer-sized thin film magnetic elements was used to control the movement of magnetic beads (MBs). The MBs and the chip were functionalized, forming a sandwich-type assay. The MBs were transported across a detection area, and the presence of target molecules resulted in the immobilization of MBs within this area. Target quantification was accomplished by MB counting in the detection area using an optical microscope. In order to demonstrate the versatility of the microarray, biotinylated antiavidin was selected as the target protein. In this case, avidin-functionalized MBs and an avidin-functionalized detection area were used. With a total assay time of 1 to 1.5 h (depending on the labeling approach used), a limit of detection in the attomole range was achieved. Compared to on-chip surface plasmon resonance biodetection systems, our method has a larger dynamic range and is about a factor of 500 times more sensitive. Furthermore, our MB transportation system can operate in any chip-based biosensor platform, thereby significantly improving traditional biosensors.
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| 13. |
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| 14. |
- Bengtsson, Stefan, et al.
(författare)
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Accumulation of wet-deposited radiocaesium and radiostrontium by spring oilseed rape (Brássica napus L.) and spring wheat (Tríticum aestívum L.)
- 2013
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Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491 .- 1873-6424. ; 182, s. 335-342
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Tidskriftsartikel (refereegranskat)abstract
- The accumulation of 134Cs and 85Sr within different parts of spring oilseed rape and spring wheat plants was investigated, with a particular focus on transfer to seeds after artificial wet deposition at different growth stages during a two-year field trial. In general, the accumulation of radionuclides in plant parts increased when deposition was closer to harvest. The seed of spring oilseed rape had lower concentrations of 85Sr than spring wheat grain. The plants accumulated more 134Cs than 85Sr. We conclude that radionuclides can be transferred into human food chain at all growing stages, especially at the later stages. The variation in transfer factors during the investigation, and in comparison to previous results, implies the estimation of the risks for possible transfer of radionuclides to seeds in the events of future fallout during a growing season is still subjected to considerable uncertainty.
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| 15. |
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| 16. |
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| 17. |
- Bengtsson, Stefan, et al.
(författare)
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Interception and retention of wet-deposited radiocaesium and radiostrontium on a ley mixture of grass and clover
- 2014
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 497-498, s. 412-419
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Tidskriftsartikel (refereegranskat)abstract
- The aims of this study were to assess the potential radioactive contamination of fodder in the case of accidental radionuclide fallout, and to analyse the relationship between interception and retention of radionuclides as a function of biomass and Leaf Area Index (LAI). The interception and the retention of wet deposited Cs-134 and Sr-85 in ley (a mixture of grass and clover) were measured after artificial wet deposition in a field trial in Uppsala (eastern central Sweden). The field trial had a randomised block design with three replicates. Cs-134 and Sr-85 were deposited at six different growth stages during two growing seasons (2010 and 2011) using a rainfall simulator. The biomass was sampled in the center of each parcel 2 to 3 h after deposition and at later growth stages (1 to 5) during the growing season. The above ground biomass and LAI were measured as well. The interception of radionuclides by the ley was largest at the late growth stages; the spike and tassel/flowering (code 5:6) in the 1st year, and at flowering/initial flowering (code 6:5) in the 2nd year. There was a correlation between radionuclide interception and above ground plant biomass, as well as with LAI, for both radionuclides in both years. The highest activity concentrations of both radionuclides were measured after deposition at the late growth stages and were found to be higher in the 2nd year. The weathering half-lives were shorter at the earlier growth stages than at the later growth stages for both radionuclides. For the magnitude of deposition chosen in our experiment, it can be concluded that the above ground biomass is a good predictor and the LAI a more uncertain predictor of the interception of radiocaesium and radiostrontium by ley grass and clover. (C) 2014 Elsevier B.V. All rights reserved.
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| 18. |
- Bengtsson, Stefan, et al.
(författare)
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Interception of wet deposited and transfers of radiocaesiumand radiostrontium by Brássica napus L. and Tríticumaestívum L.
- 2011
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Ingår i: Radioprotection. - : EDP Sciences. - 0033-8451 .- 1769-700X. ; 46, s. S475-S478
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to assess the interception and transfer to edible part of wet deposited 134Cs and 85Sr to spring oilseed rape and spring wheat and the dependency of the intercepted fraction on the development stage e.g. the total plant biomass. The radionuclides, 134Cs and 85Sr, were deposited at six different development stages using a rainfall simulator. The results showed that there was a positive correlation between the interception fraction for 134Cs and 85Sr and the biomass both for spring oilseed rape and spring wheat. The interception fraction and transfer factors were highest at growing stage of senescence (ripening) for both crops
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| 19. |
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| 20. |
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| 21. |
- Bersani, Cinzia, et al.
(författare)
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Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis
- 2016
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Ingår i: Oncotarget. - : Impact Journals LLC. - 1949-2553. ; 7:2, s. 1895-1911
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Tidskriftsartikel (refereegranskat)abstract
- RNA-binding proteins (RBPs) play important roles in the regulation of gene expression through a variety of post-transcriptional mechanisms. The p53-induced RBP Wig-1 (Zmat3) binds RNA through its zinc finger domains and enhances stability of p53 and N-Myc mRNAs and decreases stability of FAS mRNA. To identify novel Wig-1-bound RNAs, we performed RNA-immunoprecipitation followed by high-throughput sequencing (RIP-Seq) in HCT116 and Saos-2 cells. We identified 286 Wig-1-bound mRNAs common between the two cell lines. Sequence analysis revealed that AU-rich elements (AREs) are highly enriched in the 3'UTR of these Wig-1-bound mRNAs. Network enrichment analysis showed that Wig-1 preferentially binds mRNAs involved in cell cycle regulation. Moreover, we identified a 2D Wig-1 binding motif in HIF1A mRNA. Our findings confirm that Wig-1 is an ARE-BP that regulates cell cycle-related processes and provide a novel view of how Wig-1 may bind mRNA through a putative structural motif. We also significantly extend the repertoire of Wig-1 target mRNAs. Since Wig-1 is a transcriptional target of the tumor suppressor p53, these results have implications for our understanding of p53-dependent stress responses and tumor suppression.
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| 22. |
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| 23. |
- Blomstrand, Malin, 1974, et al.
(författare)
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Different reactions to irradiation in the juvenile and adult hippocampus
- 2014
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 90:9, s. 807-815
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cranial radiotherapy is an important tool in the cure of primary brain tumors. Unfortunately, it is associated with late-appearing toxicity to the normal brain tissue, including cognitive impairment, particularly in children. The underlying mechanisms are not fully understood but involve changes in hippocampal neurogenesis. Recent studies report essentially different responses in the juvenile and the adult brain after irradiation, but this has never been verified in a comparative study. Materials and methods: We subjected juvenile (9-day-old) and adult (6-month-old) male rats to a single dose of 6 Gray (Gy) whole brain irradiation and euthanized them 6 hours, 7 days or 4 weeks later. Hippocampal lysates were analyzed for caspase-3 activity (apoptosis) and the expression of cytokines, chemokines and growth factors. Four weeks after irradiation, the number of microglia (expressing ionized calcium-binding adapter molecule 1, Iba-1), activated microglia (expressing cluster of differentiation 68 [CD68]), bromodeoxyuridine (BrdU) incorporation and granule cell layer (GCL) volume were assessed. Results: The major findings were (i) higher baseline BrdU incorporation (cell proliferation) in juvenile than in adult controls, which explains the increased susceptibility to irradiation and higher level of acute cell death (caspase activity) in juvenile rats, leading to impaired growth and subsequently a smaller dentate gyrus volume 4 weeks after irradiation, (ii) more activated (CD68-positive) microglia in adult compared to juvenile rats, regardless of irradiation, and (iii) differently expressed cytokines and chemokines after cranial irradiation in the juvenile compared to the adult rat hippocampus, indicating a more pro-inflammatory response in adult brains. Conclusion: We found essentially diverse irradiation reactions in the juvenile compared to the adult hippocampus, indicating different mechanisms involved in degeneration and regeneration after injury. Strategies to ameliorate the cognitive deficits after cranial radiotherapy should therefore likely be adapted to the developmental level of the brain.
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| 24. |
- Blomstrand, Malin, et al.
(författare)
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Estimated clinical benefit of protecting neurogenesis in the developing brain during radiation therapy for pediatric medulloblastoma.
- 2012
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Ingår i: Neuro-Oncology. - : Oxford University Press (OUP). - 1523-5866 .- 1522-8517. ; 14:7, s. 882-889
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Tidskriftsartikel (refereegranskat)abstract
- We sought to assess the feasibility and estimate the benefit of sparing the neurogenic niches when irradiating the brain of pediatric patients with medulloblastoma (MB) based on clinical outcome data. Pediatric MB survivors experience a high risk of neurocognitive adverse effects, often attributed to the whole-brain irradiation that is part of standard management. Neurogenesis is very sensitive to radiation, and limiting the radiation dose to the hippocampus and the subventricular zone (SVZ) may preserve neurocognitive function. Radiotherapy plans were created using 4 techniques: standard opposing fields, intensity-modulated radiotherapy (IMRT), intensity-modulated arc therapy (IMAT), and intensity-modulated proton therapy (IMPT). Mean dose to the hippocampus and SVZ (mean for both sites) could be limited to 88.3% (range, 83.6%-91.0%), 77.1% (range, 71.5%-81.3%), and 42.3% (range, 26.6%-51.2%) with IMAT, IMRT, and IMPT, respectively, while maintaining at least 95% of the prescribed dose in 95% of the whole-brain target volume. Estimated risks for developing memory impairment after a prescribed dose of 23.4 Gy were 47% (95% confidence interval [CI], 21%-69%), 44% (95% CI, 21%-65%), 41% (95% CI, 22%-60%), and 33% (95% CI, 23%-44%) with opposing fields, IMAT, IMRT, and IMPT, respectively. Neurogenic niche sparing during cranial irradiation of pediatric patients with MB is feasible and is estimated to lower the risks of long-term neurocognitive sequelae. Greatest sparing is achieved with intensity-modulated proton therapy, thus making this an attractive option to be tested in a prospective clinical trial.
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| 25. |
- Blomstrand, Malin, 1974, et al.
(författare)
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No clinically relevant effect on cognitive outcomes after low-dose radiation to the infant brain: A population-based cohort study in Sweden
- 2014
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 53:9, s. 1143-1150
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Tidskriftsartikel (refereegranskat)abstract
- While the detrimental effects of cranial radiotherapy on the developing brain are well known, the effects on cognitive performance of low doses of ionizing radiation is less studied. We performed a population-based cohort study to determine whether low doses of ionizing radiation to the brain in infancy affects cognitive function later in life. Further we hypothesized that the dose to the hippocampus predicts cognitive late side effects better than the anterior or the posterior brain doses. Material and methods. During 1950 - 1960 3860 boys were treated with radiation in Sweden for cutaneous hemangiomas before the age of 18 months. Of these, 3030 were analyzed for military test scores at the age of 18 years and 2559 for the highest obtained educational level. Results. Logical, spatial and technical test scores were not affected by increasing irradiation doses. The verbal test scores displayed a significant trend for decreasing scores with increasing doses to the hippocampus (p = 0.005). However, the absolute mean difference between the zero dose and the highest dose category (median 680 mGy) was very small, only 0.64 stanine points, and the significance was dependent on the highest dose category, containing few subjects. The educational level was not affected by brain irradiation. Overall, the hippocampal dose was a better predictor of late cognitive side effects than the doses to the anterior or the posterior brain. In conclusion, there was no decrease in logical, spatial and technical verbal or global test scores after ionizing radiation doses up to 250 mGy, but a subtle decrease in verbal test scores if the highest dose category was included (median 680 mGy). However, the clinical relevance of this decline in the highest dose group is questionable, since we could not find any effect on the highest obtained educational level.
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| 26. |
- Boda, Ulrika, et al.
(författare)
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Screen-Printed Corrosion-Resistant and Long-Term Stable Stretchable Electronics Based on AgAu Microflake Conductors
- 2023
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society. - 1944-8244 .- 1944-8252. ; 15:9, s. 12372-
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Tidskriftsartikel (refereegranskat)abstract
- High-throughput production methods such as screen printing can bring stretchable electronics out of the lab into the market. Most stretchable conductor inks for screen printing are based on silver nanoparticles or flakes due to their favorable performance-to-cost ratio, but silver is prone to tarnishing and corrosion, thereby limiting the stability of such conductors. Here, we report on a cost-efficient and scalable approach to resolve this issue by developing screen printable inks based on silver flakes chemically coated by a thin layer of gold. The printed stretchable AgAu conductors reach a conductivity of 8500 S cm-1, remain conductive up to 250% strain, show excellent corrosion and tarnishing stability, and are used to demonstrate wearable LED and NFC circuits. The reported approach is attractive for smart clothing, as the long-term functionality of such devices is expected in a variety of environments. © 2023 The Authors.
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| 27. |
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| 28. |
- Carlsson, Emelie, et al.
(författare)
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A real-estate price index for Stockholm, 1726–1875
- 2022
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Ingår i: Banking, Bonds, National Wealth, and Stockholm House Prices, 1420–2020. - Stockholm : Ekerlids förlag. - 9789189323605 ; , s. 297-334
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter presents new, nominal and real price indices for real estate in Stockholm from 1726 up to 1875. The new series presented here can be linked to already existing price indices for real estate in Stockholm: from 1875 up to 1957; from 1957 to1975 3 and; from 1975 up to 2020.For this, a new database is used that covers registered real estate transactions in the present inner city of Stockholm for the period and the method of repeated sales is applied. The indices are based on information from 22,169 unique transactions. To control for qualitative changes inthe housing stock, a database of 7,915 issued building permits has been used.
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| 29. |
- Edvinsson, Rodney, et al.
(författare)
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A real estate price index for Stockholm, Sweden 1818–2018 : putting the last decades housing price boom in a historical perspective
- 2021
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Ingår i: Scandinavian Economic History Review. - : Informa UK Limited. - 0358-5522 .- 1750-2837. ; 69:1, s. 83-101
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Tidskriftsartikel (refereegranskat)abstract
- Earlier research describes the development of real housing prices as a ‘hockey stick’, i.e. of long stagnation followed by a sharp upturn in recent decades. A problem is that there are very few indices of residential property covering longer periods. Using a database of around 10,900 sales, this study presents a historical housing price index for Stockholm 1818–1875, which extend a previous index by 57 years, one of the longest for any city. A so-called repeated sales index is compared to a sales price appraisals ratio index. We show that in real terms there have been two long upswings, in 1855–1887 and 1993–2018. In other periods, real prices were stagnant or even slightly declining. The nineteenth century upturn did not end in a crash, but was followed by stagnation for a century. There are many similarities between the two upturns. For example, both coincided with the demographic expansion and were preceded by deregulations. During both periods, properties became more expensive relative income levels.
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| 30. |
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| 31. |
- Ekström, Magnus Pär, et al.
(författare)
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The association of body mass index, weight gain and central obesity with activity-related breathlessness : the Swedish Cardiopulmonary Bioimage Study
- 2019
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Ingår i: Thorax. - : BMJ Publishing Group Ltd. - 0040-6376 .- 1468-3296. ; 74:10, s. 958-964
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m(2)) is rapidly increasing globally and its impact on breathlessness is unclear.Methods: This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score >= 1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.Results: We included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m(2); and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.Conclusion: Breathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.
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| 32. |
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| 33. |
- Enjin, Anders, et al.
(författare)
-
Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell-motor neuron circuit
- 2017
-
Ingår i: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 37:23, s. 5634-5647
-
Tidskriftsartikel (refereegranskat)abstract
- When activating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with motor neurons suggests that Renshaw cells have an integral role in movement, a role that is yet to be elucidated. Here we used the selective expression of the nicotinic cholinergic receptor α2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid transporter (VIAAT) in Renshaw cells. Loss of VIAAT from Chrna2Cre-expressing Renshaw cells did not impact any aspect of drug-induced fictive locomotion in the neonatal mouse or change gait, motor coordination, or grip strength in adult mice of both sexes. However, motor neurons from neonatal mice lacking VIAAT in Renshaw cells received spontaneous inhibitory synaptic input with a reduced frequency, showed lower input resistance, and had an increased number of proprioceptive glutamatergic and calbindin-labeled putative Renshaw cell synapses on their soma and proximal dendrites. Concomitantly, Renshaw cells developed with increased excitability and a normal number of cholinergic motor neuron synapses, indicating a compensatory mechanism within the recurrent inhibitory feedback circuit. Our data suggest an integral role for Renshaw cell signaling in shaping the excitability and synaptic input to motor neurons.
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| 34. |
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| 35. |
- Eriksson, Harald, 1977-
(författare)
-
Bacterial viruses targeting multi-resistant Klebsiella pneumoniae and Escherichia coli
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The global increase in antibiotic resistance levels in bacteria is a growing concern to our society and highlights the need for alternative strategies to combat bacterial infections. Bacterial viruses (phages) are the natural predators of bacteria and are as diverse as their hosts, but our understanding of them is limited. The current levels of knowledge regarding the role that phage play in the control of bacterial populations are poor, despite the use of phage therapy as a clinical therapy in Eastern Europe.The aim of this doctoral thesis is to increase knowledge of the diversity and characteristics of bacterial viruses and to assess their potential as therapeutic agents towards multi-resistant bacteria.Paper I is the product of de novo sequencing of newly isolated phages that infect and kill multi-resistant Klebsiella pneumoniae. Based on similarities in gene arrangement, lysis cassette type and conserved RNA polymerase, the creation of a new phage genus within Autographivirinae is proposed.Paper II describes the genomic and proteomic analysis of a phage of the rare C3 morphotype, a Podoviridae phage with an elongated head that uses multi-resistant Escherichia coli as its host.Paper III describes the study of a pre-made phage cocktail against 125 clinical K. pneumoniae isolates. The phage cocktail inhibited the growth of 99 (79 %) of the bacterial isolates tested. This study also demonstrates the need for common methodologies in the scientific community to determine how to assess phages that infect multiple serotypes to avoid false positive results.Paper IV studies the effects of phage predation on bacterial virulence: phages were first allowed to prey on a clinical K. pneumoniae isolate, followed by the isolation of phage-resistant bacteria. The phage resistant bacteria were then assessed for their growth rate, biofilm production in vitro. The virulence of the phage resistant bacteria was then assessed in Galleria mellonella. In the single phage treatments, two out of four phages showed an increased virulence in the in G. mellonella, which was also linked to an increased growth rate of the phage resistant bacteria. In multi-phage treatments however, three out of five phage cocktails decreased the bacterial virulence in G. mellonella compared to an untreated control.
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| 36. |
- Eriksson, Klas AM
(författare)
-
Ideologins bilhandlare
- 2021
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Ingår i: Axess. - 1651-0941. ; :8
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Recension (populärvet., debatt m.m.)
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| 37. |
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| 38. |
- Eriksson, Klas A. M., 1983-
(författare)
-
How the City was Owned : Property Markets, Property Rights, and Entrepreneurship in Stockholm, Sweden 1726-2018
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this dissertation three central themes concerning the ownership and allocation in the city of Stockholm over long periods are examined.The first theme property markets involves constructions of real estate price indexes spanning from 1726 to 2018. The second theme property rights concerns the regulation of private and public ownership of real estate from 1874 to 2010. The third theme entrepreneurship in urban environments is an examination of the efforts to influence property markets and property rights through entrepreneurship in difference sectors from the 1920s to the 2010s.With an extensive amount of empirical material, this dissertation examines and relates the three themes to each other and shed new light on urban dynamics from an historical perspective. This dissertation is particularly important today when ownership and prices of real estate in cities are burning issues, and entrepreneurship is of central importance for development. The dissertation is a compilation thesis consisting of six articles.
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| 39. |
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| 40. |
- Eriksson, Klas A.M.
(författare)
-
Stadslivet är större än Amazon
- 2020
-
Ingår i: Smedjan. - 1102-7304 .- 1402-5353.
-
Tidskriftsartikel (populärvet., debatt m.m.)
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| 41. |
- Eriksson, Klas, et al.
(författare)
-
A revised perspective on innovation policy for renewal of mature economies – Historical evidence from finance and telecommunications in Sweden 1980–1990
- 2019
-
Ingår i: Technological forecasting & social change. - : Elsevier. - 0040-1625 .- 1873-5509. ; 147, s. 152-162
-
Tidskriftsartikel (refereegranskat)abstract
- What is the role of innovation policy for accomplishing renewal of mature industries in Western economies? Drawing upon an unusually rich dataset spanning 9752 digitized archival documents, we categorize and code decisions taken by policymakers on several levels while also mapping and quantifying the strategic activities of both entrant firms and incumbent monopolists over a decade. Our data concerns two empirical cases from Sweden during the time period 1980–1990: the financial sector and the telecommunications sector. In both industries, a combination of technological and institutional upheaval came into motion during this time period which in turn fueled the revitalization of the Swedish economy in the subsequent decades. Our findings show that Swedish policymakers in both cases consistently acted in order to promote the emergence of more competition and de novo entrant firms at the expense of established monopolies. The paper quantifies and documents this process while also highlighting several enabling conditions. In conclusion, the results indicate that successful innovation policy in mature economies is largely a matter of strategically dealing with resourceful vested interest groups, alignment of expectations, and removing resistance to industrial renewal.
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| 42. |
- Eriksson, Klas
(författare)
-
Den digitala revolutionen slår igenom på bred front genom pandemin
- 2020
-
Ingår i: Respons : recensionstidskrift för humaniora & samhällsvetenskap. - 2001-2292. ; :3
-
Recension (övrigt vetenskapligt/konstnärligt)abstract
- I kriser testas våra samhällen på ett unikt sätt, men kriser kan också föra mänskligheten framåt. Digitaliseringen av samhället är en av de faktorer som kan få en positiv skjuts tack vare det globala ekonomiska experiment som just nu pågår. Precis som första världskriget gav den andra industriella revolutionen en rejäl skjuts, kan krisen till följd av covid-19 vara det som gör att den digitala revolutionen slår igenom på radikalt bredare front.
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| 43. |
- Eriksson, Klas, 1983, et al.
(författare)
-
Design and Characterization of H-Band (220-325 GHz) Amplifiers in a 250-nm InP DHBT Technology
- 2014
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Ingår i: IEEE Transactions on Terahertz Science and Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 2156-342X .- 2156-3446. ; 4:1, s. 56-64
-
Tidskriftsartikel (refereegranskat)abstract
- Design and characterization of InP DHBT amplifiers in common-emitter and common-base topologies are presented. Both one-stage and multistage circuits are demonstrated. For one of the amplifiers, a peak gain of 24 dB at 255 GHz is measured, which is among the highest reported gains for HBT amplifiers above 200 GHz, and more than 10 dB gain at 210-315 GHz. The noise figure of this amplifier is measured on-wafer at 240-295 GHz, and it demonstrates a minimum noise figure of 10.4 dB at 265 GHz, which is the lowest reported noise figure for HBT amplifiers above 200 GHz.
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| 44. |
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| 45. |
- Eriksson, Klas, 1983, et al.
(författare)
-
H-band MMIC amplifiers in 250 nm InP DHBT
- 2012
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Ingår i: 19th International Conference on Microwaves, Radar and Wireless Communications, MIKON 2012, Warsaw, 21-23 May 2012. - 9781457714351 ; 2, s. 744-747
-
Konferensbidrag (refereegranskat)abstract
- In this paper, single-stage and multistage amplifiers of two different topologies, common-base with resistive feedback and common-emitter, operating at up to 290 GHz are presented and demonstrated. The amplifiers use an indium-phosphide (InP) double-heterojunction bipolar transistor (DHBT) process. The multistage common-emitter amplifier demonstrates a gain above 10 dB from 220 to 280 GHz with a peak gain of 15 dB while the multistage common-base amplifier demonstrates a gain of 16 dB at 265 GHz.
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| 46. |
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| 47. |
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| 48. |
- Eriksson, Klas
(författare)
-
How the City is Regulated : General and Specific Regulation in Planning and Building Legislations in Stockholm, Sweden 1874- 2010
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper examines the level of generality and specificity of the city planning and building law and its predecessors in Sweden (from now on abbreviated PBL[1]) from 1874 to 2010. The aim is to explore whether Jarrick and Bondesson’s theory that laws tend to be more general in formulation the more advanced the society becomes also holds for markets. By coding every law issue[2] in every law section in every PBL (the most important law regulating public and private ownership of real estate and city development) from 1874 to 2010 as either “general”, “specific”, or “middle” in formulation this paper shows an evolution of law formulation in regard to precision and demarcation. The category “general” concerns a formulation that is abstract, holistic, and open to numerous interpretations; the category “specific” refers to a formulation that is concrete, defined and that can only be interpreted in one way. The category “middle” is in between these extremes. This method is inspired by Jarrick and Bondesson in their examination of law formulation in constitutions over a period of 4000 years, which suggests that young non-complex societies have a high ratio of specific law formulation and that the laws tend to become more general the more complex and developed a society becomes. This study finds that the general and especially the middle category expanded relative to the specific category during the investigated period, which lends some support to Jarrick’s and Bondesson’s hypothesis – while also indicating that this evolution moves faster in markets than in whole societies. The share of law issues belonging to the specific category reached a peak in 1874 and 1907, radically decreased in 1931 and 1947, and increased slightly in 1987 and 2010. The middle category had the opposite trend line. The general category was only represented by 10 percent of law issues in 1874, which more than doubled in 2010. Also, the number of law issues radically increased during the period. These results are also related to theories of rationalization and bureaucratization. Less complex societies have more specific rules, which are more straightforward for agents to navigate, and do not require a large bureaucracy. The transformation toward a more complex society generates the adoption of more general rules, but also a growth in the number of rules and a bureaucracy that rises to administer these rules, especially to resolve various uncertainties. This process of rationalization and bureaucratization also entails a suffocation of small-scale initiatives and entrepreneurship, which in turn lays the foundation for future creative destruction of the institutional framework and established organizations. However, in Sweden such a transformation in the area of PBL has not yet occurred. Instead, a type of institutional stagnation can be observed for the period 1947 to 2010, following a period of volatility and dynamics between 1874 and 1947. [1] In this paper PBL not only refers to the PBL of 1987 and 2010 but also its predesserssors from 1874, 1907, 1931, 1947 (which was not called PBL at the time of their fomulation and implementation).[2] A law issue is a part of a law section that regulates one phenomenon.
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| 49. |
- Eriksson, Klas, 1983, et al.
(författare)
-
InP DHBT Amplifier Modules Operating Between 150 and 300 GHz Using Membrane Technology
- 2015
-
Ingår i: IEEE Transactions on Microwave Theory and Techniques. - 0018-9480 .- 1557-9670. ; 63:2, s. 433-440
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we present WR05 (140-220 GHz) and WR03 (220-325 GHz) five-stage amplifier modules with novel membrane microstrip-to-waveguide transitions. The modules use a 250-nm InP double heterojunction bipolar transistor (DHBT) technology and multilayer thin-film microstrip transmission lines. The waveguide transitions use E-plane probes on 3- μm-thin GaAs membrane substrate. Beam lead connectors integrated on the transition eliminate the need of highly reactive bond wires. In addition, process steps such as backside metallization, backside vias, and nonrectangular dicing of the integrated circuits (ICs) are not required. The WR05 amplifier module demonstrates a peak gain of 24 dB at 245 GHz and more than 10-dB gain from 155 to 270 GHz. The WR-03 module has 19-dB gain from 230 to 254 GHz with input and output return loss better than 10 dB from 225 to 330 GHz. The two modules were also characterized in terms of noise. The minimum noise figures were measured to 9.7 dB at 195 GHz and 10.8 dB at 240 GHz for the WR05 and WR03 modules, respectively. To the authors' best knowledge, these are the first published results on an InP DHBT amplifier modules operating at these high frequencies. It is also the first time that membrane technology is used for IC packaging, regardless of IC technology.
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| 50. |
- Eriksson, Klas, 1983
(författare)
-
InP DHBT Amplifiers and Circuit Packaging up to Submillimeter-Wave Frequencies
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis treats the design and characterization of amplifiers operating up tosubmillimeter-wave frequencies and packaging of such circuits into waveguidemodules. The circuits use an advanced indium phosphide (InP) double heterojunctionbipolar transistor (DHBT) process with a multilayer back-end. Several amplifiers inthe frequency range from 80 to 300 GHz with state-of-the-art performance arepresented. The amplifiers utilize different transistor configurations: common-emitter,common-base, and cascode. One of the amplifiers, a five-stage common-emittercircuit, demonstrates 24 dB gain at 255 GHz with a minimum noise figure of 10.4 dBat 265 GHz. This is the lowest reported noise figure for amplifiers in bipolartechnology operating at such high frequencies. Circuits like these can findapplications in a variety of systems such as wireless high data-rate communicationlinks and high-resolution imaging systems.Furthermore, amplifiers with the highest reported bandwidths for transistorbasedamplifiers, regardless of transistor technology, are presented in this thesis.These amplifiers use distributed topologies to achieve such wideband characteristics.The widest bandwidth is reached with a 2-cascaded distributed amplifier that has anaverage gain of 16 dB from 2 to 237 GHz, i.e., a bandwidth of 235 GHz.A potential problem with integrated circuits with a large front-side metallizationis the risk of resonating parasitic modes within the circuit substrate. The influence ofsuch resonances is studied through simulations and measurements of passive andactive circuits. It is shown that a resistive Si carrier underneath the circuit is aneffective method to eliminate the effects of parasitic substrate modes.The high operating frequencies of these circuits make the development of afunctional packaging method challenging. In this thesis, two waveguide InP DHBTamplifier modules operating in the frequency bands 150‒260 GHz and 210‒300 GHzusing a novel waveguide-to-circuit transition realized in membrane technology aredemonstrated. It is the first published results on InP DHBT amplifier modulesoperating at these high frequencies. Furthermore, membrane technology has not beenused in packaging of transistor-based integrated circuits before. One of the amplifiermodules is measured at a temperature of 100 K. The noise temperature of the moduleis reduced from 3500 K at room temperature to 1800 K when cooled. This is the firstreported characterization of an InP DHBT circuit at cryogenic temperature.
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