SwePub - sökning: WFRF:(Eriksson Lovisa)

Numrering	Referens	Omslagsbild	Hitta
1.	Eriksson, Helena, 1965- (författare) Att utveckla algebraiskt tänkande genom lärandeverksamhet : En undervisningsutvecklande studie i flerspråkiga klasser i grundskolans tidigaste årskurser 2021 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The aim of this thesis is to develop and explore teaching possible to promote algebraic thinking together with young, multilingual students six to twelve years old. One underlying assumption for the aim is that algebraic thinking can be developed by students participating in learning activities that are characterized by collective mathematical reasoning on relations between quantities of positive whole and rational numbers. Two overall research questions support this work: (1) What in students work indicate algebraic thinking identified in learning activities and as experiences of algebraic thinking? (2) How can learning models manifest in learning activity, in what ways do learning models change and enhance, and which characteristics of learning actions are enabled? Data was produced by interviews and from research lessons with students in lower grades in a multilingual Swedish school. The research lessons were focused on learning activity as suggested by Davydov (1990, 2008/1986), aimed at developing theoretical thinking – here algebraic thinking. They were staged in two research projects conducted as networks of learning studies. In these learning studies, the group of teachers iteratively designed and revised learning activities whereby the students could identify mathematical knowledge and collectively solve mathematical problems. The findings in the articles signal that learning models were developed as rudimentary, preliminary, prototypical and finally symbolic. Rudimentary models were grounded in algebraic thinking when the students analysed problem situations and identified the problem. Preliminary and prototypical models were developed by initiating and formalising actions understood as algebraic thinking. Different tools were initiated by the students and the teachers. These tools were formalised by the students. The students used algebraic symbols and line-segments to think together when comparing different quantities (Article 2). They carried out operations using unknown quantities when reflecting on additive and multiplicative relationships (Article 3). The students also used algebraic symbols to reflect on subtraction as non-commutative (Article 3). The different tools they used interacted on different levels of generalisation (Article 1). Algebraic thinking grounded the students reflections but interacted with, for example, fractional thinking in their arguments during the development of their learning models (Article 4). The different ways of thinking interacted in arguments when developing the rudimentary, the preliminary and the prototypical models. However, in the conclusion of their collective reasoning and in the development of the symbolic learning models, these different ways of thinking were intertwined in the same arguments (Article 4).As a conclusion, the four articles signal that learning models including algebraic symbols developed in a learning activity can be used by newly-arrived immigrant students to reflect on structures of numbers.
2.	Ahlberg, Erik, et al. (författare) Measurement report : Black carbon properties and concentrations in southern Sweden urban and rural air-the importance of long-range transport 2023 Ingår i: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 23:5, s. 3051-3064 Tidskriftsartikel (refereegranskat)abstract Soot, or black carbon (BC), aerosol is a major climate forcer with severe health effects. The impacts depend strongly on particle number concentration, size and mixing state. This work reports on two field campaigns at nearby urban and rural sites, 65gkm apart, in southern Sweden during late summer 2018. BC was measured using a single-particle soot photometer (SP2) and Aethalometers (AE33). Differences in BC concentrations between the sites are driven primarily by local traffic emissions. Equivalent and refractory BC mass concentrations at the urban site were on average a factor 2.2 and 2.5, with peaks during rush hour up to a factor g1/44, higher than the rural background levels. The number fraction of particles containing a soot core was significantly higher in the city. BC particles at the urban site were on average smaller by mass and had less coating owing to fresh traffic emissions. The organic components of the fresh traffic plumes were similar in mass spectral signature to hydrocarbon-like organic aerosol (HOA), commonly associated with traffic. Despite the intense local traffic (g1/4g30g000 vehicles passing per day), PM1, including organic aerosol, was dominated by aged continental air masses even at the curbside site. The fraction of thickly coated particles at the urban site was highly correlated with the mass concentrations of all measured chemical species of PM1, consistent with aged, internally mixed aerosol. Trajectory analysis for the whole year showed that air masses arriving at the rural site from eastern Europe contained approximately double the amount of BC compared to air masses from western Europe. Furthermore, the largest regional emissions of BC transported to the rural site, from the Malmö-Copenhagen urban area, are discernible above background levels only when precipitation events are excluded. We show that continental Europe and not the Malmö-Copenhagen region is the major contributor to the background BC mass concentrations in southern Sweden.
3.	Andersson, Sofia Lovisa, et al. (författare) Långtidsförsök med membranbioreaktor för förbättrad avloppsvattenrening i kombination med kompakt slambehandling 2023 Rapport (övrigt vetenskapligt/konstnärligt)abstract Henriksdals reningsverk i Stockholm byggs nu ut och om för ökad kapacitet (från 0,8 till 1,6 miljoner PE) och för förbättrad reningsgrad (6 mg TN/l, 0,20 mg TP/L, 5 mg BOD7/l). Projektet inkluderar uppgradering av den befintliga konventionella aktivslamprocessen till en ny membranbioreaktorprocess (MBR) med mer än 1,6 m2 installerad membranyta.Det inkluderar även utökad förbehandling och ett nytt steg för primärslamförtjockning. Termofil rötning av tjockt slam (~6 % TS) vid hög organisk belastning och relativt låg uppehållstid kommer ersätta dagens mesofila rötning.För att öka kunskapen om MBR-teknik i nordiskt klimat har Stockholm Vatten och Avfall (SVOA) och IVL Svenska Miljöinstitutet genomfört långtidsstudier på en membranprocess i pilotskala på FoU-anläggningen Hammarby Sjöstadsverk, som ligger i anslutning till Henriksdals reningsverk. MBR-piloten togs i drift 2013 och byggdes om till sin nuvarande utformning under 2016. År 2017 kompletterades MBR-piloten med en slamlinje för att kunna studera olika aspekter av slamrötning.Under 2021 kördes MBR-piloten med ett fast inflöde på 4,1 m3/h, vilket är 37 % högre än det designade medelflödet, med externt tillförskaffad glycerol och internt producerad VFA-kolkälla för efterdenitrifikation.Aluminium (PAX) användes i stället för trevärt järn (PIX) som komplement till tvåvärt järn (FeSO4) för fosforutfällning. Detta gjordes för att testa driftstrategin för den första MBR-linjen i Henriksdals reningsverk. Medelhalter av kväve och fosfor i utgående vatten var 3,9 mg TN/L respektive 0,07 mg TP/L, vilket innebär att utsläppsvärden uppfylldes även i år. För att uppnå detta krävdes 8,6 g Fe2+/m3 och 0,9 g Al3+/m3.Under försök med fluxförhöjare tillsattes totalt 17,8 g järn (Fe2++ Fe3+)/m3. Glyceroldosen motsvarade 17,3 g COD/m3, och för användning av internt producerad VFA motsvarande dosen 15,5 g COD/m3. Den något högre förbrukningen av fosforfällningskemikalier jämfört med 2020, 1,29 mol metall per mol avlägsnad fosfor, berodde främst på en lägre bio-P aktivitet under 2021. År 2021 var fosforsläppshastigheten mycket låg under våren, ex. < 1 g PO4-P/kg VSS,h i juni men återhämtade sig under sommaren med t.ex. 5,5 g PO4-P/kg VSS,h i juli, efter att doseringen av skumdämpare stoppades.Järn- och aluminiumhalten i det aktiva slammet var 6,2 respektive 0,7 %. Genomsnittlig total slamålder under 2021 var 17,2 dagar och luftad medelslamålder var 7 dagar. Nitrifikation var alltid komplett med utgående ammoniumkoncentrationer under 2 mg/L, förutom vecka 25.Tester med användning av internt producerad VFA som kolkälla visade att den specifika COD-förbrukningen var nästan densamma som för glycerol när man jämförde årsgenomsnittet från 2021 och 2020. Utgående nitrat och total kvävereduktion var liknande under försöket med VFA som resten av året, då glycerol användes.Liksom tidigare år rengjordes membranen i membrantank 1 (MT1) med oxalsyra och membranen i MT2 med citronsyra. Båda membranen rengjordes också med natriumhypoklorit. Membranen kördes med ett genomsnittligt flux på 21 till 25 L/(m2·h), men med startvecka 25 testades fullskaledesignens maximala nettoflux på 30 L/(m2·h) i piloten under 25 veckor. Netto-TMP varierade mellan 49 och 218 mbar för MT1 och mellan 51 och 146 mbar för MT2. TMP reducerades efter varje återhämtningsrengöring (RC) med hypoklorit, men effekten varade inte länge. Permeabiliteten var generellt över 200 L/(m2·h·bar) under hela 2021–2022 för båda membranen. Återhämtningsrengöringar gjordes två gånger med hypoklorit och en gång med syror under 2021. Under 2022 genomfördes en slutlig RC, först med hypoklorit sedan med syror. Den första RC för MT1 resulterade i en tydlig ökning av permeabiliteten efter rengöring. För MT2 var den största ökningen av permeabiliteten resultatet av en citronsyra-MC (en vecka efter hypoklorit-RC).Följande RC i slutet av 2021 och i mars 2022 hade tydliga men mindre positiva inverkan på permeabiliteten. Före den första RC var permeabiliteten högre för MT1 (rengöras med oxalsyra) jämfört med MT2 (rengöras med citronsyra). Efter de första RC hade båda membranen liknande permeabilitet. Som ett resultat av den tuffa driftstrategin från vecka 25 2021 minskade permeabiliteten ganska snabbt efter RC. MT2 nådde en stabil nivå runt 250-300 L/(m2·h·bar) medan MT1 sjönk ytterligare till som lägst 200 L/(m2·h·bar).Utsläpp av klorerade föreningar mättes under den slutliga återställningsrengöringen med natriumhypoklorit. Utsläppsprocessen var långsammare än förväntat och generellt sett observerades inga tydliga tecken på dämpning av utsläppen under provtagningens 21 timmar. Även om sammansatta prover på flera timmar under natten inte ger tillräckligt med detaljer, drogs slutsatsen att utsläppen kan vara skadliga under hela RC-processen ur ett exponeringsperspektiv. Exempelvis nådde trikloramin sin topp vid 36 gånger den rekommenderade gränsen, klorgas vid 73 % av korttidsexponeringsgränsen (15 min exponering) och kloroform vid 9 % av den yrkesmässiga exponeringsgränsen (genomsnittlig arbetsdag på 8 timmar).För att följa upp tidigare mätningar av växthusgaserna lustgas (N2O) och metan (CH4) genomfördes en ny mätkampanj under flera månader i 2021. Generellt sett var utsläppen som observerades 2021 betydligt högre än i tidigare kampanjer och särskilt höga N2O-utsläpp från membrantanken kunde observeras. Någon tydlig orsak kunde inte identifieras men den högre inkommande belastningen med bibehållna reningskrav och ett "bättre" provtagningsupplägg kan delvis vara en förklaring.I samarbete med Kemira genomfördes tester med en fluxförhöjande produkt (flux enhancer). Ingen uppenbar positiv eller negativ förändring i permeabiliteten på grund av dosering av fluxförhöjare kunde dock identifieras utifrån de kontinuerliga processparametrar som övervakades och vanliga variationer i permeabilitet samt effekten av membranrengöring.Eftersom skumbildning är ett vanligt fenomen i MBR-anläggningar genomfördes tester med ett skumdämpande medel som doserades i pulser och kontinuerligt till den biologiska behandlingen under perioden med kraftig skumbildning (mars-juni). Även om skumning inte upphörde helt så kunde en god minskning och kontroll av skumning uppnås. En optimal effekt konstaterades vid en kontinuerlig dos på > 10 ppm. Men även om produkten har visat sig ha en positiv effekt på skumning i MBR-piloten, framstår inte en permanent användning i fullskala som ekonomiskt genomförbar på grund av den höga förbrukningen.Tester med reducerat RAS-flöde från 4×Qin enligt design till 2×Qin syftade till att minska energiförbrukningen. Ett minskat RAS-flöde skulle dock innebära en ökad slamkoncentration i membrantankarna, vilket kan ha negativa effekter på membranets prestanda med mer igensättning, vilket i sin tur kan leda till ökad luftning för membranrengöring och behov av tätare membrantvättar. Projektgruppen kunde dock inte observera några negativa effekter av det minskade RAS-flödet på membranets prestanda.Under 2021 genomfördes tester med övergång från mesofil till termofil rötning, avvattning av rötslam efter mesofil och termofil rötning, samt termofil rötning vid hög organisk belastning (OLR) och låg hydraulisk uppehållstid (HRT) i slampiloten. Resultat visar att övergången från mesofil till termofil rötning kan ske utan större problem om den organiska belastningen minskades lite vid den mest kritiska temperaturen och att stabil drift uppnåddes efter 10-12 dagar. Att utvärdera avvattningen av mesofilt och termofilt rötat slam var svårare och inga tydliga skillnader kunde observeras. En slutsats var dock att de metoder som användes för att bestämma avvattningsbarhet eller optimal polymerdos inte framstår som tillförlitliga. Försök med hög organisk belastning vid termofil rötning visade att rötkammarens prestanda kunde bibehållas upp till en OLR på cirka 4 kg VS/m3, d och en HRT på 12 d. När belastningen ökades ytterligare och HRT minskade, minskade prestandan vad gäller utrötningsgrad och biogas-/metanproduktion, även om själva reaktordriften fortfarande var stabil.Den totala resursåtgången i piloten visade att konsumtionen av glycerol var densamma som för den framtida Henriksdalsdesignen, även om kvävebelastningen i piloten var 21 % högre och den genomsnittliga totala kvävekoncentrationen i utgående vatten var med 3,9 mg TN/L lägre än design på 6 mg TN/L. Järn-/metallförbrukningen var också 73 % av den framtida Henriksdalsdesignen, även om fosforbelastningen till piloten var cirka 50 % högre jämfört med designvärden och utgående fosfatkoncentrationerna låg under målkoncentrationen. Detta förklaras främst av EBPR-aktiviteten i pilotprojektet. Dessutom var förbrukningen av rengöringskemikalier lägre än den framtida Henriksdalsdesignen även om inflödet till piloten var 30 % högre än designen.
4.	Bark, Glenn, et al. (författare) Politikerna struntar i klimatforskningen : 420 forskare: Regeringens politik är katastrofal – nu måste fler svenskar kräva en omställning 2023 Ingår i: Aftonbladet Debatt. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)abstract DEBATE. We researchers have long demanded that the government take climate research seriously and speed up the transition to a sustainable society.Instead, the government is pursuing a policy that deliberately increases emissions. Now more citizens need to raise their voices and show that we demand a knowledge-based climate transition, and it is urgent.
5.	Björnsson, Lovisa, et al. (författare) Impact of biogas energy crops on greenhuse gas emissions, soil organic matter and food crop production - a case study on farm level 2013 Rapport (övrigt vetenskapligt/konstnärligt)
6.	Bodecker-Zingmark, L., et al. (författare) Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease 2023 Ingår i: Digestive Diseases and Sciences. - : Springer. - 0163-2116 .- 1573-2568. ; 68, s. 608-615 Tidskriftsartikel (refereegranskat)abstract Background: The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown.Aims: To study typical antibodies for IBD in the preclinical phase in a cohort of Northern Sweden.Methods: Antibodies typical for IBD (ASCA, pANCA, lactoferrin-ANCA, antibodies to goblet cells, and pancreas antigen) were analyzed in 123 subjects with preclinical ulcerative colitis (UC), 54 subjects with preclinical Crohn's disease (CD) and in 390 sex- and age-matched controls. In addition, in a subset of subjects, inflammatory markers (CRP, albumin, calprotectin and ferritin) were measured in plasma.Results: The mean years between blood samples and IBD diagnosis were for UC 5.1 (SD 3.5) years and CD 5.6 (SD 3.5) years. There was no difference in the proportion of overall positive antibodies between subjects who later developed IBD compared to controls (16.9% vs. 12.3%; p = 0.137). The subjects who later developed CD had a significantly higher proportion of positive ASCA compared to controls (9.3% vs 2.8%; p = 0.034), but for all other antibodies, there were no differences compared to control subjects. Subjects with preclinical IBD and elevated antibodies showed significantly higher plasma calprotectin levels compared to subjects without antibodies (980 μg/L vs 756 μg/L; p = 0.042), but there was no difference in the levels of CRP, albumin and ferritin.Conclusions: We found no significant increase in antibodies typical for IBD years before diagnosis except for ASCA, which was slightly more common in subjects who later developed CD. Very few subjects had detectable antibodies to goblet cells and pancreas antigen.
7.	Boge, Lukas, 1987, et al. (författare) Cubosomes post-loaded with antimicrobial peptides: Characterization, bactericidal effect and proteolytic stability 2017 Ingår i: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 526:1-2, s. 400-412 Tidskriftsartikel (refereegranskat)abstract Novel antibiotics, such as antimicrobial peptides (AMPs), have recently attended more and more attraction. In this work, dispersed cubic liquid crystalline gel (cubosomes) was used as drug delivery vehicles for three AMPs (AP114, DPK-060 and LL-37). Association of peptides onto cubosomes was studied at two cubosome/peptide ratios using high performance liquid chromatography, ?-potential and circular dichroism measurements. AMPs impact on the cubosome structure was investigated using small angle x-ray scattering and cryogenic transmission electron microscopy. The antimicrobial effect of the AMP loaded cubosomes was studied in vitro by minimum inhibitory concentration and time-kill assays. Proteolytic protection was investigated by incubating the formulations with two elastases and the antimicrobial effect after proteolysis was studied using radial diffusion assay. Different association efficacy onto the cubosomes was observed among the AMPs, with LL-37 showing greatest association (>60%). AP114 loaded cubosomes displayed a preserved antimicrobial effect, whereas for LL-37 the broad spectrum bacterial killing was reduced to only comprise Gram-negative bacteria. Interestingly, DPK-060 loaded cubosomes showed a slight enhanced effect against S. aureus and E. coli strains. Moreover, the cubosomes were found to protect LL-37 from proteolytic degradation, resulting in a significantly better bactericidal effect after being subjected to elastase, compared to unformulated peptide.
8.	Boge, Lukas, et al. (författare) Lipid-based liquid crystals as carriers for antimicrobial peptides : Phase behavior and antimicrobial effect 2016 Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 32:17, s. 4217-4228 Tidskriftsartikel (refereegranskat)abstract The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an important part of future treatment strategies of various bacterial infection diseases. However, AMPs have relatively low stability, because of proteolytic and chemical degradation. As a consequence, carrier systems protecting the AMPs are greatly needed, to achieve efficient treatments. In addition, the carrier system also must administrate the peptide in a controlled manner to match the therapeutic dose window. In this work, lyotropic liquid crystalline (LC) structures consisting of cubic glycerol monooleate/water and hexagonal glycerol monooleate/oleic acid/water have been examined as carriers for AMPs. These LC structures have the capability of solubilizing both hydrophilic and hydrophobic substances, as well as being biocompatible and biodegradable. Both bulk gels and discrete dispersed structures (i.e., cubosomes and hexosomes) have been studied. Three AMPs have been investigated with respect to phase stability of the LC structures and antimicrobial effect: AP114, DPK-060, and LL-37. Characterization of the LC structures was performed using small-angle X-ray scattering (SAXS), dynamic light scattering, ζ-potential, and cryogenic transmission electron microscopy (Cryo-TEM) and peptide loading efficacy by ultra performance liquid chromatography. The antimicrobial effect of the LCNPs was investigated in vitro using minimum inhibitory concentration (MIC) and time-kill assay. The most hydrophobic peptide (AP114) was shown to induce an increase in negative curvature of the cubic LC system. The most polar peptide (DPK-060) induced a decrease in negative curvature while LL-37 did not change the LC phase at all. The hexagonal LC phase was not affected by any of the AMPs. Moreover, cubosomes loaded with peptides AP114 and DPK-060 showed preserved antimicrobial activity, whereas particles loaded with peptide LL-37 displayed a loss in its broad-spectrum bactericidal properties. AMP-loaded hexosomes showed a reduction in antimicrobial activity.
9.	Boge, Lukas, 1987, et al. (författare) Liquid crystalline particles for delivery of antimicrobial peptides 2018 Ingår i: Abstracts of Papers of the American Chemical Society. - : American Chemical Society (ACS). - 0065-7727. ; 255 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
10.	Engberg, Lovisa, et al. (författare) Explicit optimization of plan quality measures in intensity-modulated radiation therapy treatment planning 2017 Ingår i: Medical physics (Lancaster). - : WILEY. - 0094-2405. ; 44:6, s. 2045-2053 Tidskriftsartikel (refereegranskat)abstract Purpose: To formulate convex planning objectives of treatment plan multicriteria optimization with explicit relationships to the dose-volume histogram (DVH) statistics used in plan quality evaluation. Methods: Conventional planning objectives are designed to minimize the violation of DVH statistics thresholds using penalty functions. Although successful in guiding the DVH curve towards these thresholds, conventional planning objectives offer limited control of the individual points on the DVH curve (doses-at-volume) used to evaluate plan quality. In this study, we abandon the usual penalty-function framework and propose planning objectives that more closely relate to DVH statistics. The proposed planning objectives are based on mean-tail-dose, resulting in convex optimization. We also demonstrate how to adapt a standard optimization method to the proposed formulation in order to obtain a substantial reduction in computational cost. Results: We investigated the potential of the proposed planning objectives as tools for optimizing DVH statistics through juxtaposition with the conventional planning objectives on two patient cases. Sets of treatment plans with differently balanced planning objectives were generated using either the proposed or the conventional approach. Dominance in the sense of better distributed doses-at-volume was observed in plans optimized within the proposed framework. Conclusion: The initial computational study indicates that the DVH statistics are better optimized and more efficiently balanced using the proposed planning objectives than using the conventional approach.
11.	Engberg, Lovisa, et al. (författare) Increased accuracy of planning tools for optimization of dynamic multileaf collimator delivery of radiotherapy through reformulated objective functions 2018 Ingår i: Physics in Medicine and Biology. - : IOP PUBLISHING LTD. - 0031-9155 .- 1361-6560. ; 63:12 Tidskriftsartikel (refereegranskat)abstract The purpose of this study is to examine in a clinical setting a novel formulation of objective functions for intensity-modulated radiotherapy treatment plan multicriteria optimization (MCO) that we suggested in a recent study. The proposed objective functions are extended with dynamic multileaf collimator (DMLC) delivery constraints from the literature, and a tailored interior point method is described to efficiently solve the resulting optimization formulation. In a numerical planning study involving three patient cases, DMLC plans Pareto optimal to the MCO formulation with the proposed objective functions are generated. Evaluated based on pre-defined plan quality indices, these DMLC plans are compared to conventionally generated DMLC plans. Comparable or superior plan quality is observed. Supported by these results, the proposed objective functions are argued to have a potential to streamline the planning process, since they are designed to overcome the methodological shortcomings associated with the conventional penalty-based objective functions assumed to cause the current need for time-consuming trial-and-error parameter tuning. In particular, the increased accuracy of the planning tools imposed by the proposed objective functions has the potential to make the planning process less complicated. These conclusions position the proposed formulation as an alternative to existing methods for automated planning.
12.	Eriksson, Helena, et al. (författare) Algebraic and fractional thinking in collective mathematical reasoning 2021 Ingår i: Educational Studies in Mathematics. - : Springer Science and Business Media LLC. - 0013-1954 .- 1573-0816. ; 108:3, s. 473-491 Tidskriftsartikel (refereegranskat)abstract This study examines the collective mathematical reasoning when students and teachers in grades 3, 4, and 5 explore fractions derived from length comparisons, in a task inspired by the El´konin and Davydov curriculum. The analysis showed that the mathematical reasoning was mainly anchored in mathematical properties related to fractional or algebraic thinking. Further analysis showed that these arguments were characterised by interplay between fractional and algebraic thinking except in the conclusion stage. In the conclusion and the evaluative arguments, these two types of thinking appeared to be intertwined. Another result is the discovery of a new type of argument, identifying arguments, which deals with the first step in task solving. Here, the different types of arguments, including the identifying arguments, were not initiated only by the teachers but also by the students. This in a multilingual classroom with a large proportion of students newly arrived. Compared to earlier research, this study offers a more detailed analysis of algebraic and fractional thinking including possible patterns within the collective mathematical reasoning. An implication of this is that algebraic and fractional thinking appear to be more intertwined than previous suggested.
13.	Eriksson, Helena, et al. (författare) Fair sharing and division – mathematical reasoning regarding integers and fractions in preschool and preschool class 2024 Ingår i: Proceedings of Cerme 13. - : Alfréd Rényi Institute of Mathematics, Budapest, Hungary and ERME. - 9789637031045 ; , s. 2096-2103 Konferensbidrag (refereegranskat)abstract This paper identifies and discusses children’s mathematical reasoning in preschool and preschool class when they work with a fair sharing case. The case came from a selection of cases designed to promote collective mathematical as well as ethical reasoning. Data comes from six children’s work when sharing four paper biscuits between three soft toys, first when the children were five years old and then, a year later, when they were six years old. The results show that their reasoning, both when they were five and six, used mathematical and ethical arguments. In preschool class, the students were able to use each other’s arguments in collective reasoning to identify, predict, and verify their reasoning. The students began to measure the fraction parts of a remainder but could not evaluate the conclusion with respect to what is aspects for division; equal numbers and equal size. The results also signal that teacher’s input, of posing evaluating questions, appears to stimulate the reasoning.
14.	Eriksson, Helena, et al. (författare) Fractions and algebraic reasoning 2017 Konferensbidrag (refereegranskat)
15.	Eriksson, Lovisa, 1983- (författare) Den virtuella kroppen : Presentationer av jaget i svenska dagboksbloggar 2009 Ingår i: Sociologisk forskning. - Uppsala : Sociologförbundet. - 0038-0342 .- 2002-066X. ; 46:4, s. 47-60 Tidskriftsartikel (refereegranskat)abstract There are no bodies on the internet and yet, there are bodies on the internet. This article deals with representations of the ‘virtually physical’ in personal weblogs. To examine the data drawn from 14 weblogs, a qualitative content analysis is made. The results show that the virtual body is widely present in these particular internet settings and that it is most commonly described as female. Moreover, the virtual body is to a large extent a fragmented body that one either takes control over or is controlled by.
16.	Eriksson, Lovisa, 1983- (författare) Online Together : A Sociological Study of the Concept of Togetherness and the Contemporary Conditions for Social Interaction 2016 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The recent advances in digital communication technologies have altered the way in which people socialize on a day-to-day basis. A question that has arisen in relation to this is what being somewhere together actually means at a time when our interactions are no longer confined to shared physical places.The phenomenon of being somewhere together (also: togetherness) has previously been studied within the fields of social presence theory (which focuses on digitally mediated ‘togetherness’ and primarily departs from a psychological perspective) and microsociology (which takes an arguably more interactional approach to the idea of being together but primarily focuses on face-to-face interaction). Therefore, what is missing is a conceptualization of togetherness that can account both for togetherness in contexts other than those mediated face- to-face and for the ways in which togetherness is potentially ‘created’ in social interaction. The purpose of this thesis is to address this shortcoming by examining the underlying problem of being together and the conceptualizations of being together in the two aforementioned discourses. For the theoretical analyses, the example of online chat conversation is used as the primary focus of study.The thesis comprises three main parts. In the first part, the question of why being together has become difficult to conceptualize since the introduction of electronic and digital communication technologies is explored. The second part of the thesis is a review of what being together stands for in social presence theory and microsociology, respectively. In the third part, the two reviewed understandings of being together are examined. Here, it is observed that social presence theory portrays being together as something that occurs in informational environments, while microsociology portrays it instead as something pertaining to framed (or specified) social situations. Thereafter follows a critical examination of being together in informational situations and being together in framed social situations in which the notions are analysed in relation to online chat. It is concluded that the second view of being together (as a framed activity) is more promising for the future study of togetherness in online chat environments, and potentially also for togetherness in digitally mediated environments more generally.
17.	Eriksson, Lovisa (författare) The Virtual Body : The Self and the Body in Swedish Diary Blogs 2009 Ingår i: Sociologisk forskning. - 0038-0342 .- 2002-066X. ; :4, s. 47-60 Tidskriftsartikel (refereegranskat)abstract The Virtual Body. The Self and the Body in Swedish Diary Blogs There are no bodies on the internet and yet, there are bodies on the internet. This article deals with representations of the 'virtually physical' in personal weblogs. To examine the data drawn from 14 weblogs, a qualitative content analysis is made. The results show that the virtual body is widely present in these particular internet settings and that it is most commonly described as female. Moreover, the virtual body is to a large extent a fragmented body that one either takes control over or is controlled by.
18.	Eriksson, Mina, et al. (författare) Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment 2018 Ingår i: International Journal of Radiation Oncology, Biology, Physics. - : Elsevier BV. - 0360-3016 .- 1879-355X. ; 100:1, s. 174-187 Tidskriftsartikel (refereegranskat)abstract Purpose: We previously reported that sphere-forming non-small cell lung cancer (NSCLC) tumor-initiating cells (TICs) have an altered activation of DNA damage response-and repair proteins and are refractory to DNA-damaging treatments. We analyzed whether chromatin organization plays a role in the observed refractoriness.Methods and Materials: Bulk cells and TICs from the NSCLC H23 and H1299 cell lines were examined using cell viability, clonogenic survival, Western blot, short interfering RNA analysis, and micronucleus assay.Results: NSCLC TICs displayed elevated heterochromatin markers trimethylated lysine 9 of histone H3 and heterochromatin protein 1 gamma relative to bulk cells and reduced cell viability upon histone deacetylase inhibition (HDACi). Vorinostat and trichostatin A increased the euchromatin markers acetylated lysine 9/14 of histone H3 and lysine 8 of histone H4, and HDACi pretreatment increased the phosphorylation of the DNA damage response proteins ataxia telangiectasia mutated and DNA-dependent protein kinase, catalytic subunit, upon irradiation in TICs. HDACi sensitized TICs to cisplatin and to some extent to ionizing irradiation. The protectiveness of a dense chromatin structure was indicated by an enhanced frequency of micronuclei in TICs following irradiation, after knockdown of heterochromatin protein 1 gamma.Conclusions: Although confirmatory studies in additional NSCLC model systems and with respect to analyses of other DNA damage response proteins are needed, our data point toward a heterochromatic structure of NSCLC TICs, such that HDACi can sensitize TICs to DNA damage.
19.	Eriksson, Sara, et al. (författare) Numerical Simulations and Empirical Data for the Evaluation of Daylight Factors in Existing Buildings in Sweden 2019 Ingår i: Energies. - : MDPI AG. - 1996-1073 .- 1996-1073. ; 12:11 Tidskriftsartikel (refereegranskat)abstract Point Daylight Factor (DFP) has been used for daylighting design in Sweden for more than 40 years. Progressive densification of urban environments, in combination with stricter regulations on energy performance and indoor environmental quality of buildings, creates complex daylight design challenges that cannot be adequately solved with DFP. To support a development of the current and future daylight indicators in the Swedish context, the authors have developed a comprehensive methodology for the evaluation of daylight levels in existing buildings. The methodology comprises sample buildings of various use and their digital replicas in 3D, detailed numerical simulations and correlations of diverse DF metrics in existing buildings, a field investigation on residents' satisfaction with available daylight levels in their homes, and a comparison between the numerical and experimental data. The study was deliberately limited to the evaluation of DF metrics for their intuitive understanding and easy evaluation in real design projects. The sample buildings represent typical architectural styles and building technologies between 1887 and 2013 in Gothenburg and include eight residential buildings, two office buildings, two schools, two student apartment buildings, and two hospitals. Although the simulated DFP is 1.4% on average, i.e., above the required 1%, large variations have been found between the studied 1200 rooms. The empirical data generally support the findings from the numerical simulations, but also bring unique insights in the residences' preferences for rooms with good daylight. The most remarkable result is related to kitchens, typically the spaces with the lowest DF values, based on simulations, while the residents wish them to be the spaces with the most daylight. Finally, the work introduces a new DF metric, denoted DFW, which allows daylighting design in early stages when only limited data on the building shape and windows' arrangement are available.
20.	Flygt, Hjalmar, et al. (författare) Successful tyrosine kinase inhibitor discontinuation outside clinical trials - data from the population-based Swedish chronic myeloid leukaemia registry 2021 Ingår i: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 193:5, s. 915-921 Tidskriftsartikel (refereegranskat)abstract Clinical trials show that tyrosine kinase inhibitor (TKI) treatment can be discontinued in selected patients with chronic myeloid leukaemia (CML). Although updated CML guidelines support such procedure in clinical routine, data on TKI stopping outside clinical trials are limited. In this retrospective study utilising the Swedish CML registry, we examined TKI discontinuation in a population-based setting. Out of 584 patients diagnosed with chronic-phase CML (CML-CP) in 2007-2012, 548 had evaluable information on TKI discontinuation. With a median follow-up of nine years from diagnosis, 128 (23%) discontinued TKI therapy (>= 1 month) due to achieving a DMR (deep molecular response) and 107 (20%) due to other causes (adverse events, allogeneic stem cell transplant, pregnancy, etc). Among those stopping in DMR, 49% re-initiated TKI treatment (median time to restart 4 center dot 8 months). In all, 38 patients stopped TKI within a clinical study and 90 outside a study. After 24 months 41 center dot 1% of patients discontinuing outside a study had re-initiated TKI treatment. TKI treatment duration pre-stop was longer and proportion treated with second-generation TKI slightly higher outside studies, conceivably affecting the clinical outcome. In summary we show that TKI discontinuation in CML in clinical practice is common and feasible and may be just as successful as when performed within a clinical trial.
21.	Forsner, Maria, 1954-, et al. (författare) When children die : a survey in Sweden about hospital guidelines related to care after death 2014 Konferensbidrag (refereegranskat)
22.	Hedefalk, Maria, 1971-, et al. (författare) Five year Olds in between Sharing and Division 2022 Ingår i: Philosophy of Mathematics Education Journal. - 1465-2978. ; 39 Tidskriftsartikel (refereegranskat)abstract Sharing and division are two concepts that have overlapping properties, and both are connected to the interpretation of fairness. In the present study, we study preschool children’s work with a case where eight biscuits were shared between soft toys. The focus is onthe different arguments that the children express. The results show that children use both ethical arguments and mathematical arguments in their solutions. Some of the arguments can be categorised as ‘Fair sharing related to number of pieces only’ or ‘Fair sharing employing ad hoc attempts at equal size’. The arguments that were coded as sharing not associated with mathematical sense of fairness were either classified as ethical reasoning or play. In the discussion, we raise the need of the combination of ethical reasoning and mathematical arguments if we want to create situations for children to develop critical thinking.
23.	Hedefalk, Maria, 1971-, et al. (författare) Matematiska och etiska resonemang i förskolan : didaktisk modellering som intervention 2024 Ingår i: Forskning om undervisning och lärande. - : Lärarstiftelsen. - 2000-9674 .- 2001-6131. ; 12:2, s. 68-84 Tidskriftsartikel (refereegranskat)abstract The article examines didactic choices in teaching where mathematics and sustainable development meet. The purpose of the teaching was to encourage preschool children to reason collectively about distribution problems. It was the children's reasoning about possible solutions that was in focus, not a correct answer. The preschool teacher's role was to create opportunities for agency: enable childrens own contributions to knowledge, pit different conflicting perspectives on sustainable solutions against each other and discuss the solutions. Based on the didactic modeling method, researchers and preschool teachers discussed the teaching based on different expertise. Documentation created during these meetings was analysed, in order to investigate if the didactic what and how questions could help the preschool teachers create agency in teaching. The result shows how reflection on the didactic issues created opportunities for agency in relation to organization of time and environment, of pairing children for collective work and language development work.
24.	Hedefalk, Maria, et al. (författare) Matematiska och etiska resonemang i förskolan – didaktisk modellering som intervention : [Mathematical and ethical reasoning in preschool – didactic modeling as an intervention] 2024 Ingår i: Forskning om undervisning och lärande. - 2000-9674 .- 2001-6131. ; 12:2, s. 68-84 Tidskriftsartikel (refereegranskat)abstract I artikeln undersöks didaktiska val i undervisning där matematik och hållbar utveckling möts. Undervisningens syfte var att uppmuntra förskolebarn att kollektivt resonera kring fördelningsproblem. Det var barnens resonemang om möjliga lösningar som låg i fokus, inte ett rätt svar. Förskollärarens roll var att skapa möjligheter för agens: att barnen kunde göra egna bidrag i kunskapandet, där barnen kunde ställa olika konflikterande perspektiv om hållbara lösningar mot varandra och diskutera lösningarna. Utifrån metoden didaktisk modellering förde forskare och förskolläre diskussioner om undervisningen utifrån olika expertis. Dokumentationen som skapades under dessa möten analyserades, för att pröva om en didaktisk modell som hanterar de didaktisk vad- och hur-frågorna kunde hjälpa förskollärarna att skapa agens i undervisningen. Resultatet visar hur reflektion kring de didaktiska frågorna kan skapa möjligheter för agens i undervisningen. Didaktiska lösningar handlade om organisation av tid och miljö, om svårigheter att para ihop barn för kollektivt arbete samt språkutvecklande arbete.
25.	Igelström, Peter, 1976- (författare) 20 frågor om bibliometri 2018 Ingår i: Ett bibliotek i takt med tiden. - Linköping : Linköpings universitetsbibliotek. - 9789176851470 ; , s. 137-142 Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract De flesta yrkesverksamma vid forskningsbibliotek eller inom forskarvärlden har förmodligen på ett eller annat sätt kommit i kontakt med bibliometri, eller åtminstone stött på begreppet. För den som inte är närmare insatt kan dock bibliometrin lätt uppfattas som lite av ett mysterium. Vad går en citeringsanalys egentligen ut på? Vad är det för indikatorer som man talar om inom bibliometrin? Och vad är den ”norska modellen” för någonting?För den som i likhet med mig har en något diffus bild av hur bibliometriska analyser går till, hjälper här medlemmar av Linköpings universitetsbiblioteks bibliometrigrupp till att reda ut begreppen. Gruppen tillkom 2007 på initiativ av bibliotekets dåvarande överbibliotekarie Marianne Hällgren. Syftet var att kunna erbjuda enskilda forskare, forskargrupper och fakulteter vid Linköpings universitet bibliometrisk rådgivning och analys. Internationella rankinglistor över lärosäten hade vid den här tiden börjat få större uppmärksamhet och mätning av universitetens forskningsproduktion fick därför allt större betydelse. Vid forskningsbibliotek hade man sedan länge gjort bibliometriska analyser med hjälp av manuella metoder, men nya digitala verktyg tillät nu att mer avancerade analyser utfördes. Vid LiUB valde man att skapa en grupp som jobbade med bibliometri istället för att som på många andra lärosäten tillsätta enskilda tjänster, detta för att göra bibliometriarbetet mindre personberoende. I april 2009 inrättades vid biblioteket avdelningen Publiceringens infrastruktur (PI) med ansvar för bland annat bibliometriverksamheten vid Linköpings universitetsbibliotek.
26.	Jansson, Märit, et al. (författare) Tillbaka till den hållbara staden : tankar från kursen Stadens utmaningar 2015 Rapport (övrigt vetenskapligt/konstnärligt)
27.	Jennbacken, Karin, et al. (författare) Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells 2019 Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 20:23 Tidskriftsartikel (refereegranskat)abstract Paracrine factors can induce cardiac regeneration and repair post myocardial infarction by stimulating proliferation of cardiac cells and inducing the anti-fibrotic, antiapoptotic, and immunomodulatory effects of angiogenesis. Here, we screened a human secretome library, consisting of 923 growth factors, cytokines, and proteins with unknown function, in a phenotypic screen with human cardiac progenitor cells. The primary readout in the screen was proliferation measured by nuclear count. From this screen, we identified FGF1, FGF4, FGF9, FGF16, FGF18, and seven additional proteins that induce proliferation of cardiac progenitor cells. FGF9 and FGF16 belong to the same FGF subfamily, share high sequence identity, and are described to have similar receptor preferences. Interestingly, FGF16 was shown to be specific for proliferation of cardiac progenitor cells, whereas FGF9 also proliferated human cardiac fibroblasts. Biosensor analysis of receptor preferences and quantification of receptor abundances suggested that FGF16 and FGF9 bind to different FGF receptors on the cardiac progenitor cells and cardiac fibroblasts. FGF16 also proliferated naive cardiac progenitor cells isolated from mouse heart and human cardiomyocytes derived from induced pluripotent cells. Taken together, the data suggest that FGF16 could be a suitable paracrine factor to induce cardiac regeneration and repair.
28.	Juliusson, Gunnar, et al. (författare) Improved Survival of Patients with Acute Myeloid Leukemia Following Implementation of Swedish National Guidelines : Results from the AML Registry 1997-2013 2014 Ingår i: Blood. - 0006-4971 .- 1528-0020. ; 124:21 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
29.	Juliusson, G., et al. (författare) Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden 2017 Ingår i: Leukemia. - : Nature Publishing Group. - 0887-6924 .- 1476-5551. ; 31:3, s. 728-731 Tidskriftsartikel (refereegranskat)
30.	Juliusson, Gunnar, et al. (författare) Prevalence and Characteristics of Survivors from Adult Acute Myeloid Leukemia (AML) in Sweden 2014 2015 Ingår i: Blood. - 0006-4971 .- 1528-0020. ; 126:23 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
31.	Lager, Ida, et al. (författare) Novel reactions in acyl editing of phosphatidylcholine by lysophosphatidylcholine transacylase (LPCT) and acyl-CoA:glycerophosphocholine acyltransferase (GPCAT) activities in microsomal preparations of plant tissues 2015 Ingår i: Planta. - : Springer Science and Business Media LLC. - 0032-0935 .- 1432-2048. ; 241, s. 347-358 Tidskriftsartikel (refereegranskat)abstract Plants have lysophosphatidylcholine transacylase (LPCT) and acyl-CoA:glycerophosphocholine acyltransferase (GPCAT) activities. The combined action of LPCT and GPCAT provides a novel route of PC re-synthesis after its deacylation.Phosphatidylcholine (PC) is the major lipid in eukaryotic membranes and has a central role in overall plant lipid metabolism. It is also the site of production of polyunsaturated fatty acids in plants. The recently discovered acyl-CoA:glycerophosphocholine acyltransferase (GPCAT) activity in yeast provides a novel route of re-synthesising PC via lysophosphatidylcholine (LPC) after its deacylation. This route does not require the degradation of the glycerophosphocholine (GPC) into free choline, the activation of choline to CDP-choline, nor the utilization of CDP-choline by the CDP-choline:diacylglycerol cholinephosphotransferase. We show here that GPCAT activities also are present in membrane preparations from developing oil seeds of safflower and other species as well as in membrane preparations of roots and leaves of Arabidopsis, indicating that GPCAT activity plays a ubiquitous role in plant lipid metabolism. The last step in formation of GPC, the substrate for GPCAT, is the deacylation of LPC. Microsomal membranes of developing safflower seeds utilized LPC in LPC:LPC transacylation reactions (LPCT activities) creating PC and GPC. The results demonstrate that safflower membranes have LPCT and GPCAT activities that represent novel reactions for PC acyl editing. The physiological relevance of these reactions probably has to await identification of the enzymes catalysing these reactions.
32.	Lehmann, Sören, et al. (författare) Early death rates remain high in high-risk APL : update from the Swedish Acute Leukemia Registry 1997-2013 2017 Ingår i: Leukemia. - : Nature Publishing Group. - 0887-6924 .- 1476-5551. ; 31:6, s. 1457-1459 Tidskriftsartikel (refereegranskat)
33.	Markkanen, Peter, 1964-, et al. (författare) Building a joint problem-solving space: how collaboration in collective mathematical reasoning can develop 2024 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract This study investigates how collaborative, collective mathematical reasoning emerges when students jointly solve problems regarding fair sharing. Three 6-year-old children worked collaboratively in a group with a problem related to fair sharing, and their teacher was present. The data, captured in video recordings, was analysed using two frameworks: collective mathematical reasoning, and the theory of joint problem space. The results show that different things, such as physical artefacts aimed at sharing resources, challenges related to the task, and the students’ conceptions of mathematics, affect the students’ possibilities to engage in collaborative collective mathematical reasoning.
34.	Månsson, Johan, et al. (författare) Understanding and overcoming obstacles in adaptive management 2024 Ingår i: Trends in Ecology and Evolution. - : Elsevier Ltd.. - 0169-5347 .- 1872-8383. ; 38:1, s. 55-71 Forskningsöversikt (refereegranskat)abstract Adaptive management (AM) is widely promoted to improve management of natural resources, yet its implementation is challenging. We show that obstacles to the implementation of AM are related not only to the AM process per se but also to external factors such as ecosystem properties and governance systems. To overcome obstacles, there is a need to build capacities within the AM process by ensuring adequate resources, management tools, collaboration, and learning. Additionally, building capacities in the legal and institutional frames can enable the necessary flexibility in the governance system. Furthermore, in systems experiencing profound changes in wildlife populations, building such capacities may be even more critical as more flexibility will be needed to cope with increased uncertainty and changed environmental conditions.
35.	Nalin, Lovisa, et al. (författare) Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs 2014 Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 41:9, s. 1800-1810 Tidskriftsartikel (refereegranskat)abstract PurposeThe glucagon-like peptide-1 receptor (GLP-1R) has been proposed as a target for molecular imaging of beta cells. The feasibility of non-invasive imaging and quantification of GLP-1R in pancreas using the positron emission tomography (PET) tracer [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in non-diabetic and streptozotocin (STZ)–induced diabetic pigs treated with insulin was investigated.MethodsNon-diabetic (n = 4) and STZ-induced diabetic pigs (n = 3) from the same litter were examined. Development of diabetes was confirmed by blood glucose values, clinical examinations and insulin staining of pancreatic sections post mortem. Tissue perfusion in the pancreas and kidneys was evaluated by [15O]water PET/computed tomography (CT) scans. The in vivo receptor specificity of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 was assessed by administration of either tracer alone or by competition with 3–6.5 μg/kg of Exendin-4. Volume of distribution and occupancy in the pancreas were quantified with a single tissue compartment model.Results[15O]water PET/CT examinations showed reduced perfusion in the pancreas and kidneys in diabetic pigs. [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 uptake in the pancreas of both non-diabetic and diabetic pigs was almost completely abolished by co-injection of unlabeled Exendin-4 peptide. [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 uptake did not differ between non-diabetic and diabetic pigs. In all animals, administration of the tracer resulted in an immediate increase in the heart rate (HR).ConclusionPancreatic uptake of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 was not reduced by destruction of beta cells in STZ-induced diabetic pigs.
36.	Nilsson, Christer, et al. (författare) Allogeneic Transplantation in First Remission Improves Outcome in Secondary Acute Myeloid Leukemia 2014 Ingår i: Blood. - 0006-4971 .- 1528-0020. ; 124:21 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
37.	Nilsson, Christer, et al. (författare) Characterization of therapy-related acute myeloid leukemia : increasing incidence and prognostic implications 2023 Ingår i: Haematologica. - : Ferrata Storti Foundation. - 0390-6078 .- 1592-8721. ; 108:4, s. 1015-1025 Tidskriftsartikel (refereegranskat)abstract Studies of therapy-related AML (t-AML) are usually performed in selected cohorts and reliable incidence rates are lacking. In this study, we characterized, defined the incidence over time and studied prognostic implications in all t-AML patients diagnosed in Sweden between 1997 and 2015. Data were retrieved from nationwide population-based registries. In total, 6,779 AML patients were included in the study, of whom 686 (10%) had t-AML. The median age for t-AML was 71 years and 392 (57%) patients were females. During the study period, the incidence of t-AML almost doubled with a yearly increase in t-AML of 4.5% (95% confidence interval: 2.8%-6.2%), which contributed significantly to the general increase in AML incidence over the study period. t-AML solidly constituted over 10% of all AML cases during the later period of the study. Primary diagnoses with the largest increase in incidence and decrease in mortality rate during the study period (i.e., breast and prostate cancer) contributed significantly to the increased incidence of t-AML. In multivariable analysis, t-AML was associated with poorer outcome in cytogenetically intermediate-and adverse-risk cases but t-AML had no significant impact on outcome in favorable-risk AML, including core binding leukemias, acute promyelocytic leukemia and AML with mutated NPM1 without FLT3-ITD. We conclude that there is a strong increase in incidence in t-AML over time and that t-AML constitutes a successively larger proportion of the AML cases. Furthermore, we conclude that t-AML confers a poor prognosis in cytogenetically intermediate-and adverse-risk, but not in favorable-risk AML.
38.	Nilsson, Lovisa, et al. (författare) Effects of soot maturity and coating on the single particle soot photometer (SP2) response: A laboratory study 2022 Konferensbidrag (refereegranskat)
39.	Nilsson, Lovisa, et al. (författare) Relating the single particle soot photometer (SP2) signal response to soot maturity Ingår i: Aerosol Science and Technology. - 1521-7388. Tidskriftsartikel (refereegranskat)abstract Light absorbing carbonaceous aerosols produced from combustion span over a range of physicochemical properties. Soot is the most recognized species in this category and its formation process involves gradual maturation from amorphous young soot with a high hydrogen-to-carbon-ratio toward mature soot aggregates. In this work, the optical response of a single particle soot photometer (SP2) to electrical mobility size selected soot of different maturity produced by a mini-CAST soot generator is investigated. The results show that for soot of a specific mobility diameter, the laser-induced incandescence (LII) signal appears earlier and with a higher LII peak height for increasing soot maturity. The experimental observations are supported by simulations using a numerical model for the LII process. Furthermore, the effect of systematically varying the SP2 laser power on the detection of soot of different maturity using LII is explored. This work can be seen as a step toward the aim of using the SP2 instrument to identify soot particles of different maturity in the atmosphere.
40.	Olsson, Marie, et al. (författare) Ta vara på odlingens sidoströmmar – exemplet broccoli 2023 Rapport (övrigt vetenskapligt/konstnärligt)abstract Detta projekt har utforskat möjligheter att använda sidoströmmar; broccoliblad och stjälk, från broccoliproduktion till nya torkade livsmedelsingredienser. Skördehantering, skördeekonomi, lämpliga processtekniker, livscykelanalys, mikrobiologisk analys och riskbedömning, analys av näringsämnen och bioaktiva ämnen, sensorik och marknadsaspekter har undersökts.
41.	Rydén, Anneli, et al. (författare) Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs 2016 Ingår i: Nuclear Medicine and Biology. - : Elsevier BV. - 0969-8051 .- 1872-9614. ; 43:7, s. 397-402 Tidskriftsartikel (refereegranskat)abstract Introduction: Radiolabeled Exendin-4, a synthetic glucagon-like peptide-1 (GLP-1) analog, is used as a tracer for diagnostic purposes of beta-cells and in experimental animal research. Exendin-4 can be radiolabeled with Ga-68, I-111 n or (99)mTc and used for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging to diagnose insulinomas, visualization of pancreatic beta-cell mass and transplanted Islets of Langerhans. In humans, Exendin-4 is widely used as a therapeutic agent for treatment of type 2 diabetes (T2D). The compound, which is administered subcutaneously (SC) may cause nausea, vomiting and a minor increase in the heart rate (HR). However, possible side-effects on cardiovascular functions after intravenous (IV) administration have not been reported. This study describes the Exendin-4 dose at which cardiovascular side-effects occur in pigs and cynomolgus monkeys. The IV effect of the tracer on insulin secretion is also investigated in pigs. Methods: Seven clinically healthy littermate pigs (40 days old) were used; three of them were made diabetic by streptozotocin (STZ). All pigs underwent PET imaging under general anesthesia to examine the glucagon-like peptide-1 receptor (GLP-1R) in beta-cells with radiolabeled Exendin-4. A baseline tracer dose IV [Ga-68]Exendin-4 (0.025 +/- 0.010 mu g/kg) followed by a competition dose IV [Ga-68]Exendin-4 (3.98 +/- 133 mu g/kg) 60 min later were administered. Blood samples were taken and analyzed for insulin secretion by using ELISA. Cardiovascular and respiratory variables were monitored throughout the experiment. Results: Immediately after administration of the high dose [Ga-68]Exendin-4 the HR rose from 122 14 to 227 +/- 40 bpm (p < 0.01) and from 100 +/- 5 to 181 +/- 13 bpm (p < 0.01) in healthy non -diabetic and diabetes-induced pigs, respectively. The tachycardia was observed for >2 h and one healthy non-diabetic pig suffered cardiac arrest 3 h after the IV [Ga-68]Exendin-4. Arrhythmia was detected by listening to the heart with a stethoscope up to 4 days after the [Ga-68]Exendin-4 injection. In all animals, no effect on the cardiovascular system was registered after the low dose of IV [Ga-68]Exendin-4. Insulin secretion increased (p < 0.05) when IV [Ga-68]Exendin-4 was given in dosages >= 0.14 mu g/kg. Conclusions: Intravenous administration of mu g/kg [Ga-68]Exendin-4 resulted in severe tachycardia and arrhythmias in healthy non -diabetic and diabetes-induced pigs, and the insulin secretion was stimulated in healthy non diabetic animals when >= 0.14 mu g/kg [Ga-68]Exendin-4 was given.
42.	Selvaraju, Ram Kumar, et al. (författare) PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs 2014 Ingår i: Journal of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 55:Suppl. 1, s. 387- Tidskriftsartikel (refereegranskat)
43.	Selvaraju, Ram Kumar, et al. (författare) Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs 2014 Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - 1619-7070 .- 1619-7089. ; 41:S2, s. S394-S394 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
44.	Sjödahl, Gottfrid, et al. (författare) Molecular changes during progression from nonmuscle invasive to advanced urothelial carcinoma 2020 Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:9, s. 2636-2647 Tidskriftsartikel (refereegranskat)abstract Molecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient-derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple nonmuscle invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experienced a total of 357 UBC diagnoses to study the stability or change in detected molecular alterations during cancer progression. The tumors were subtyped by gene expression profiling and analyzed for hotspot mutations in FGFR3, PIK3CA and TERT, the most frequent early driver mutations in this tumor type. TP53 alterations, frequent in advanced UBC, were inferred from p53 staining pattern, and potential genomic alterations were inferred by gene expression patterns at regions harboring frequent copy number alterations. We show that early driver mutations were largely preserved in UBC recurrences. Changes in FGFR3, PIK3CA or TERT mutation status were not linked to changes in molecular subtype and aggressive behavior. Instead, changes into a more aggressive molecular subtype seem to be associated with p53 alterations. We analyze changes in gene expression from primary tumors, to recurrences and progression tumors, and identify two modes of progression: Patients for whom progression is preceded by or coincides with a radical subtype shift, and patients who progress without any systematic molecular changes. For the latter group of patients, progression may be either stochastic or depending on factors already present at primary tumor initiation.
45.	Sjöstrand, M, et al. (författare) Repeated measurements of 11β-HSD-1 activity in subcutaneous adipose tissue from lean, abdominally obese, and type 2 diabetes subjects--no change following a mixed meal. 2010 Ingår i: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme. - : Georg Thieme Verlag KG. - 1439-4286 .- 0018-5043. ; 42:11, s. 798-802 Tidskriftsartikel (refereegranskat)abstract The aim of this study was to measure 11β-HSD-1 activity in subcutaneous adipose tissue by an ex vivo method in three subgroups; lean, obese, and type 2 diabetes subjects, both in the fasting state and after a mixed meal and to determine the variability and reproducibility of this method. Eighteen subjects were investigated; 6 lean, 6 abdominally obese, and 6 type 2 diabetes subjects (BMI 22 ± 1, 30 ± 3 and 31 ± 3 kg/m², respectively). Needle biopsies were taken repeatedly and an index of 11β-HSD-1 activity was measured as percent conversion of (3)H-cortisone to (3)H-cortisol/100 mg tissue. For two separate biopsies taken in the fasting state on the same day, the within subjects CV was 16% and the between CV was 36% for 11β-HSD-1 activity for all subjects. For two biopsies taken in the fasting state at two different days, the total within subjects CV was 38% and the between subjects CV was 46%. Lean subjects had lower 11β-HSD-1 activity (4.8 ± 1.5% conversion of ³H-cortisone to ³H-cortisol/100 mg tissue) than both obese (14.4 ± 1.6% conversion, p<0.01) and type 2 diabetes subjects (11.7 ± 1.9% conversion, p<0.05) in the fasting state. There was no effect of a meal on 11β-HSD-1 activity in any of the three groups. The conclusions from this study are: 1) the variation coefficient for the ex vivo adipose tissue 11β-HSD-1 activity method was ∼25% for repeat measures within subjects; 2) food intake had no major impact on enzyme activity; and 3) 11β-HSD-1 activity in subcutaneous adipose tissue was significantly increased in obese subjects with or without T2DM compared to lean subjects without diabetes.
46.	Skelton, Alasdair, et al. (författare) Sveriges utsläpp måste minska nu, regeringen : 531 forskare: Annars är sveket monumentalt – ni kan inte säga att ni inte visste 2023 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)
47.	Stålberg, Valerie, et al. (författare) Study protocol for a modified antenatal care program for pregnant women with a low risk for adverse outcomes - a stepped wedge cluster non-inferiority randomized trial 2022 Ingår i: BMC Pregnancy and Childbirth. - London, United Kingdom : BioMed Central. - 1471-2393 .- 1471-2393. ; 22:1 Tidskriftsartikel (refereegranskat)abstract Background: It is crucial to provide care based on individual needs. Swedish health care is obliged to give care on equal conditions for the entire population. The person with the greatest need should be given the most care, and the health care system should strive to be cost-efficient. Medical and technical advances have been significant during the last decades and the recent Covid-19 pandemic has caused a shift in health care, from in-person visits to virtual visits. The majority of pregnant women with a low risk assessment have an uncomplicated antenatal course without adverse events. These women probably receive excessive and unnecessary antenatal care. This study will investigate if an antenatal care program for healthy pregnant women with a low risk for adverse outcomes could be safely monitored with fewer in-person visits to a midwife, and with some of them replaced by virtual visits.Methods: This is a non-inferiority trial where a stepped wedge cluster randomized controlled design will be used. Data collection includes register data and questionnaires that concern antenatal, obstetric and neonatal outcomes, patient- and caregiver-reported experiences, healthcare-economy, and implementation aspects. The modified antenatal care (MAC) study is performed in parts of the southeast of Sweden, which has approximately 8200 childbirths annually. At the start of the study, all antenatal care centers included in the study will use the same standard antenatal care (SAC) program. In the MAC program the in-person visits to a midwife will be reduced to four instead of eight, with two additional virtual meetings compared with the SAC program.Discussion: This presented study protocol is informed by research knowledge. The protocol is expected to provide a good structure for future studies on changed antenatal care programs that introduce virtual visits for healthy pregnant women with a low risk for adverse outcomes, without risking quality, safety, and increased costs.
48.	Sumpter, Lovisa, et al. (författare) Att göra matematik relevant inom undervisning för hållbar utveckling : Divisionen 8/3 med flerspråkiga 5 åringar 2022 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
49.	Sumpter, Lovisa, et al. (författare) Att göra matematik relevant inom undervisning för hållbar utveckling 2022 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
50.	Sumpter, Lovisa, et al. (författare) Eight shared by three : When mathematical and ethical reasoning interplay 2024 Ingår i: Quaderni di Ricerca in Didattica" QRDM (Mathematics). - 1592-5137 .- 1592-4424. ; :13, s. 447-456 Tidskriftsartikel (refereegranskat)abstract The aim of this paper is to explore students mathematical and ethical reasoning in fair sharing tasks. In our study, 8-year-old students were asked to share eight biscuits between three soft toys, where one of the toys is hungry and sad. Two analytical frameworks were used, one for mathematical reasoning and one for ethical reasoning. The results show that sharing tasks can generate several solutions in which students use different mathematical arguments combined with ethical arguments. Another result is that the different arguments often interplay with, or depend on, each other, meaning that mathematical reasoning and ethical reasoning are intertwined.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Träfflista för sökning "WFRF:(Eriksson Lovisa) "

Avgränsa träffmängd

År